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https://www.readbyqxmd.com/read/28209551/sero-prevalence-risk-factors-and-distribution-of-foot-and-mouth-disease-in-ethiopia
#1
REVIEW
Nejash Abdela
Foot and mouth disease (FMD), world's most important highly infectious and contagious trans-boundary animal diseases, is responsible for huge global losses of livestock production as well as severe impacts on international trade. This vesicular disease is caused by foot and mouth disease virus of the genus Aphthovirus, family Picornaviridae. Currently FMD is major global animal health problem and endemic in Africa including Ethiopia. This paper systematically reviewed the sero-prevalence reports, associated risk factors and distribution of FMD in Ethiopia with the main aim of making compressive document on prevalence, risk factor and distribution of the disease thus helping as a basis for designing effective control strategies...
February 14, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28207777/quantifying-the-value-of-perfect-information-in-emergency-vaccination-campaigns
#2
Naomi V Bradbury, William J M Probert, Katriona Shea, Michael C Runge, Christopher J Fonnesbeck, Matt J Keeling, Matthew J Ferrari, Michael J Tildesley
Foot-and-mouth disease outbreaks in non-endemic countries can lead to large economic costs and livestock losses but the use of vaccination has been contentious, partly due to uncertainty about emergency FMD vaccination. Value of information methods can be applied to disease outbreak problems such as FMD in order to investigate the performance improvement from resolving uncertainties. Here we calculate the expected value of resolving uncertainty about vaccine efficacy, time delay to immunity after vaccination and daily vaccination capacity for a hypothetical FMD outbreak in the UK...
February 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28207011/shedding-light-on-onychomadesis
#3
Fernanda Salgado, Marc Z Handler, Robert A Schwartz
Onychomadesis is the proximal separation of the nail plate from the nail matrix due to a temporary cessation of nail growth. It can occur in children of all ages including neonates. Diagnosis is made clinically through palpation and inspection of the nail plate. Physicians should consider underlying associations. A review of the patient's history for any viral illnesses 1 to 2 months prior to nail changes often will help identify the causative disease. Onychomadesis typically is mild and self-limited. There is no specific treatment, but a conservative approach to management is recommended with treatment of any underlying causes and supportive care...
January 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28202117/-value-of-serum-s100b-protein-and-neuron-specific-enolase-levels-in-predicting-the-severity-of-hand-foot-and-mouth-disease
#4
Jing Li, Rui-Hai Liu, Ruo-Bing Shan
OBJECTIVE: To study the value of serum S100B protein and neuron-specific enolase (NSE) levels in predicting the severity of hand, foot and mouth disease (HFMD). METHODS: Ninety children with HFMD were classified into three groups: common type, severe type, and critical type (n=30 each). Thirty healthy children were randomly selected as the control group. ELISA was used to measure serum levels of S100B protein and NSE before and at 7 days after treatment. The receiver operating characteristic (ROC) curve was used to evaluate the prediction efficiency of S100B protein and NSE for the severity of HFMD...
February 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28202026/an-indirect-enzyme-linked-immunosorbent-assay-for-the-identification-of-antibodies-to-senecavirus-a-in-swine
#5
Cheryl M T Dvorak, Zeynep Akkutay-Yoldar, Suzanne R Stone, Steven J P Tousignant, Fabio A Vannucci, Michael P Murtaugh
BACKGROUND: Senecavirus A (SVA), a member of the family Picornaviridae, genus Senecavirus, is a recently identified single-stranded RNA virus closely related to members of the Cardiovirus genus. SVA was originally identified as a cell culture contaminant and was not associated with disease until 2007 when it was first observed in pigs with Idiopathic Vesicular Disease (IVD). Vesicular disease is sporadically observed in swine, is not debilitating, but is significant due to its resemblance to foreign animal diseases, such as foot-and-mouth disease (FMD), whose presence would be economically devastating to the United States...
February 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28198671/transcriptome-analysis-reveals-dynamic-changes-in-coxsackievirus-a16-infected-hek-293t-cells
#6
Jun Jin, Rujiao Li, Chunlai Jiang, Ruosi Zhang, Xiaomeng Ge, Fang Liang, Xin Sheng, Wenwen Dai, Meili Chen, Jiayan Wu, Jingfa Xiao, Weiheng Su
BACKGROUND: Coxsackievirus A16 (CVA16) and enterovirus 71 (EV71) are two of the major causes of hand, foot and mouth disease (HFMD) world-wide. Although many studies have focused on infection and pathogenic mechanisms, the transcriptome profile of the host cell upon CVA16 infection is still largely unknown. RESULTS: In this study, we compared the mRNA and miRNA expression profiles of human embryonic kidney 293T cells infected and non-infected with CVA16. We highlighted that the transcription of SCARB2, a cellular receptor for both CVA16 and EV71, was up-regulated by nearly 10-fold in infected cells compared to non-infected cells...
January 25, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28196318/common-skin-conditions-in-children-skin-infections
#7
Brian Z Rayala, Dean S Morrell
Skin infections account for a significant subset of dermatologic conditions of childhood. Common cutaneous viral infections in children include warts, molluscum contagiosum, hand-foot-and-mouth disease, and herpes simplex. Although viral infections are self-limited and often only mildly symptomatic, they can cause anxiety, embarrassment, and health care use. Recognition of their common and atypical presentations is necessary to differentiate them from other skin conditions of similar morphology. Impetigo, cellulitis, and abscess comprise the majority of childhood bacterial skin infections and are treated with topical or systemic antibiotics that cover group A Streptococcus and Staphylococcus aureus...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28188360/seasonal-modeling-of-hand-foot-and-mouth-disease-as-a-function-of-meteorological-variations-in-chongqing-china
#8
Pin Wang, Han Zhao, Fangxin You, Hailong Zhou, William B Goggins
Hand, foot, and mouth disease (HFMD) is an enterovirus-induced infectious disease, mainly affecting children under 5 years old. Outbreaks of HFMD in recent years indicate the disease interacts with both the weather and season. This study aimed to investigate the seasonal association between HFMD and weather variation in Chongqing, China. Generalized additive models and distributed lag non-linear models based on a maximum lag of 14 days, with negative binomial distribution assumed to account for overdispersion, were constructed to model the association between reporting HFMD cases from 2009 to 2014 and daily mean temperature, relative humidity, total rainfall and sun duration, adjusting for trend, season, and day of the week...
February 10, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28184247/a-versatile-2a-peptide-based-bicistronic-protein-expressing-platform-for-the-industrial-cellulase-producing-fungus-trichoderma-reesei
#9
Venkataramanan Subramanian, Logan A Schuster, Kyle T Moore, Larry E Taylor, John O Baker, Todd A Vander Wall, Jeffrey G Linger, Michael E Himmel, Stephen R Decker
BACKGROUND: The industrial workhorse fungus, Trichoderma reesei, is typically exploited for its ability to produce cellulase enzymes, whereas use of this fungus for over-expression of other proteins (homologous and heterologous) is still very limited. Identifying transformants expressing target protein is a tedious task due to low transformation efficiency, combined with highly variable expression levels between transformants. Routine methods for identification include PCR-based analysis, western blotting, or crude activity screening, all of which are time-consuming techniques...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28180318/in-cell-shape-uncovers-dynamic-interactions-between-the-untranslated-regions-of-the-foot-and-mouth-disease-virus-rna
#10
Rosa Diaz-Toledano, Gloria Lozano, Encarnacion Martinez-Salas
No abstract text is available yet for this article.
February 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28180094/exploiting-serological-data-to-understand-the-epidemiology-of-foot-and-mouth-disease-virus-serotypes-circulating-in-libya
#11
Ibrahim Eldaghayes, Abdunaser Dayhum, Abdulwahab Kammon, Monier Sharif, Giancarlo Ferrari, Christianus Bartels, Keith Sumption, Donald P King, Santina Grazioli, Emiliana Brocchi
Sporadic outbreaks of foot-and-mouth disease (FMD) have occurred in Libya for almost fifty years. During the spring of 2013, a countrywide serosurvey was undertaken to assess the level of FMD virus circulation and identify FMD virus serotypes in the country. A total of 4221 sera were collected, comprising samples from large ruminants (LR; n=1428 samples from 357 farms) and small ruminants (SR; n=2793 samples from 141 farms). FMD sero-prevalence of NSP antibodies determined by ELISA were 19.0% (271/1428) with 95% CI (16...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28179628/the-impact-of-hand-foot-and-mouth-disease-control-policies-in-singapore-a-qualitative-analysis-of-public-perceptions
#12
Karen Siegel, Alex R Cook, Hanh La
Hand foot and mouth disease (HFMD) is a widespread pediatric disease in Asia. Most cases are relatively mild and caused by Coxsackie viruses, but in epidemics caused by Enterovirus 71, severe complications can occur. In response to the deaths of dozens of children in a 1997 outbreak (Podin in BMC Public Health 6:180,1 Abubakar in Virus Res 61(1):1-9,2 WHO in3), Singapore practices childcare centre surveillance, case-isolation, and short-term closure of centres. We conducted 44 in-depth interviews with teachers, principals, and parents at four childcare centres in Singapore to better understand experiences with current control policies...
February 8, 2017: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28176160/a-novel-enterovirus-96-circulating-in-china-causes-hand-foot-and-mouth-disease
#13
Yi Xu, Yisuo Sun, Jinmin Ma, Shuru Zhou, Wei Fang, Jiawei Ye, Limei Tan, Jingkai Ji, Dan Luo, Liqiang Li, Jiandong Li, Chunxiao Fang, Na Pei, Shuo Shi, Xin Liu, Hui Jiang, Sitang Gong, Xun Xu
Enterovirus 96 (EV-96) is a recently described member of the species Enterovirus C and is associated with paralysis and myelitis. In this study, using metagenomic sequencing, we identified a new enterovirus 96 strain (EV-96-SZ/GD/CHN/2014) as the sole pathogen causing hand, foot, and mouth disease (HFMD). A genomic comparison showed that EV-96-SZ/GD/CHN/2014 is most similar to the EV-96-05517 strain (85% identity), which has also been detected in Guangdong Province. This is the first time that metagenomic sequencing has been used to identify an EV-96 strain shown to be associated with HFMD...
February 7, 2017: Virus Genes
https://www.readbyqxmd.com/read/28173845/development-of-real-time-and-lateral-flow-strip-reverse-transcription-recombinase-polymerase-amplification-assays-for-rapid-detection-of-peste-des-petits-ruminants-virus
#14
Yang Yang, Xiaodong Qin, Yiming Song, Wei Zhang, Gaowei Hu, Yongxi Dou, Yanmin Li, Zhidong Zhang
BACKGROUND: Peste des petits ruminants (PPR) is an economically important, Office International des Epizooties (OIE) notifiable, transboundary viral disease of small ruminants such as sheep and goat. PPR virus (PPRV), a negative-sense single-stranded RNA virus, is the causal agent of PPR. Therefore, sensitive, specific and rapid diagnostic assay for the detection of PPRV are necessary to accurately and promptly diagnose suspected case of PPR. METHODS: In this study, reverse transcription recombinase polymerase amplification assays using real-time fluorescent detection (real-time RT-RPA assay) and lateral flow strip detection (LFS RT-RPA assay) were developed targeting the N gene of PPRV...
February 7, 2017: Virology Journal
https://www.readbyqxmd.com/read/28168168/enterovirus-71-infection-and-vaccines
#15
REVIEW
Eun-Je Yi, Yun-Ju Shin, Jeong-Hwan Kim, Tae-Gyun Kim, Sun-Young Chang
Hand, foot and mouth disease (HFMD) is a highly contagious viral infection affecting young children during the spring to fall seasons. Recently, serious outbreaks of HFMD were reported frequently in the Asia-Pacific region, including China and Korea. The symptoms of HFMD are usually mild, comprising fever, loss of appetite, and a rash with blisters, which do not need specific treatment. However, there are uncommon neurological or cardiac complications such as meningitis and acute flaccid paralysis that can be fatal...
January 2017: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/28166307/picornavirus-rna-is-protected-from-cleavage-by-ribonuclease-during-virion-uncoating-and-transfer-across-cellular-and-model-membranes
#16
Elisabetta Groppelli, Hazel C Levy, Eileen Sun, Mike Strauss, Clare Nicol, Sarah Gold, Xiaowei Zhuang, Tobias J Tuthill, James M Hogle, David J Rowlands
Picornaviruses are non-enveloped RNA viruses that enter cells via receptor-mediated endocytosis. Because they lack an envelope, picornaviruses face the challenge of delivering their RNA genomes across the membrane of the endocytic vesicle into the cytoplasm to initiate infection. Currently, the mechanism of genome release and translocation across membranes remains poorly understood. Within the enterovirus genus, poliovirus, rhinovirus 2, and rhinovirus 16 have been proposed to release their genomes across intact endosomal membranes through virally induced pores, whereas one study has proposed that rhinovirus 14 releases its RNA following disruption of endosomal membranes...
February 6, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28166243/development-of-a-gexp-multiplex-pcr-assay-for-the-simultaneous-detection-and-differentiation-of-six-cattle-viruses
#17
Qing Fan, Zhixun Xie, Zhiqin Xie, Xianwen Deng, Liji Xie, Li Huang, Sisi Luo, Jiaoling Huang, Yanfang Zhang, Tingting Zeng, Sheng Wang, Jiabo Liu, Yaoshan Pang
Foot-and-mouth disease virus (FMDV), Bluetongue virus (BTV), Vesicular stomatitis Virus (VSV), Bovine viral diarrheal (BVDV), Bovine rotavirus (BRV), and Bovine herpesvirus 1 (IBRV) are common cattle infectious viruses that cause a great economic loss every year in many parts of the world. A rapid and high-throughput GenomeLab Gene Expression Profiler (GeXP) analyzer-based multiplex PCR assay was developed for the simultaneous detection and differentiation of these six cattle viruses. Six pairs of chimeric primers consisting of both the gene-specific primer and a universal primer were designed and used for amplification...
2017: PloS One
https://www.readbyqxmd.com/read/28161845/temporal-and-spatial-distribution-of-lumpy-skin-disease-lsd-outbreaks-in-mashonaland-west-province-of-zimbabwe-from-2000-to-2013
#18
C Gomo, K Kanonhuwa, F Godobo, O Tada, S M Makuza
The objective of this study was to determine significant factors affecting spacio-temporal distribution of lumpy skin disease (LSD) in Mashonaland West Province of Zimbabwe. A retrospective study of LSD from year 2000 to 2013 was undertaken using records from the Department of Livestock and Veterinary Services, Mashonaland West Province, Zimbabwe. Descriptive statistics was computed on LSD cases, treatments, vaccinations, and deaths. Analysis of variance (ANOVA) was used to determine significant factors affecting LSD distribution across diverse farming sectors (localities), districts, months, and years as from 2000 to 2013 in Mashonaland West Province...
February 4, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28161579/rational-design-and-efficacy-of-a-multi-epitope-recombinant-protein-vaccine-against-foot-and-mouth-disease-virus-serotype-a-in-pigs
#19
Yimei Cao, Dong Li, Yuanfang Fu, Qifeng Bai, Yingli Chen, Xingwen Bai, Zhizhong Jing, Pu Sun, Huifang Bao, Pinghua Li, Jing Zhang, Xueqing Ma, Zengjun Lu, Zaixin Liu
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals, and outbreaks of this disease are often economically catastrophic. Recently, a series of outbreaks of foot-and-mouth disease virus (FMDV) serotype A occurred in many countries, including China. Therefore, it is necessary to develop safe and effective vaccines. We designed multi-epitope recombinant proteins A6, A7, and A8 with different three-dimensional structures and compared their immunogenicity in pigs. The results indicated that A8 conferred the greatest protection against FMDV serotype A challenge in pigs, and A8 was selected as the vaccine antigen...
February 1, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28152384/host-microrna-203a-is-antagonistic-to-the-progression-of-foot-and-mouth-disease-virus-infection
#20
Joseph Gutkoska, Michael LaRocco, Elizabeth Ramirez-Medina, Teresa de Los Santos, Paul Lawrence
Sam68 was previously shown to be a critical host factor for foot-and-mouth disease virus (FMDV) replication. MicroRNA (miR) miR-203a is reportedly a negative regulator of Sam68 expression both in vitro and in vivo. Here, transfection of miR-203a-3p and miR-203a-5p mimics separately and in combination in a porcine cell line followed by FMDV infection resulted in diminished viral protein synthesis and a 4 and 6log reduction in virus titers relative to negative controls, respectively. Unexpectedly, Sam68 expression was increased by miR-203a-5p transfection, but not miR-203a-3p...
January 30, 2017: Virology
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