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https://www.readbyqxmd.com/read/28092000/direct-and-indirect-effects-of-wastewater-use-and-herd-environment-on-the-occurrence-of-animal-diseases-and-animal-health-in-pakistan
#1
Ehsan Elahi, Liqin Zhang, Muhammad Abid, Muhammad Tariq Javed, Han Xinru
The use of wastewater for rearing domestic animals is a common phenomenon in most of the developing countries like Pakistan that face a serious shortage of freshwater resources. However, most of the literature has only focused on the indirect effects of wastewater use on animal health or productivity, and literature on the direct effects of wastewater use is rare. Therefore, this study aims to investigate the direct and indirect effects of wastewater usage on the prevalence of animal diseases and animal health in Pakistan...
January 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28090592/the-first-genome-sequences-of-human-bocaviruses-from-vietnam
#2
Tran Tan Thanh, Hoang Minh Tu Van, Nguyen Thi Thu Hong, Le Nguyen Truc Nhu, Nguyen To Anh, Ha Manh Tuan, Ho Van Hien, Nguyen Manh Tuong, Trinh Trung Kien, Truong Huu Khanh, Le Nguyen Thanh Nhan, Nguyen Thanh Hung, Nguyen Van Vinh Chau, Guy Thwaites, H Rogier van Doorn, Le Van Tan
As part of an ongoing effort to generate complete genome sequences of hand, foot and mouth disease-causing enteroviruses directly from clinical specimens, two complete coding sequences and two partial genomic sequences of human bocavirus 1 (n=3) and 2 (n=1) were co-amplified and sequenced, representing the first genome sequences of human bocaviruses from Vietnam. The sequences may aid future study aiming at understanding the evolution of the pathogen.
November 16, 2016: Wellcome Open Res
https://www.readbyqxmd.com/read/28077584/2-year-efficacy-immunogenicity-and-safety-of-vigoo-enterovirus-71-vaccine-in-healthy-chinese-children-a-randomized-open-label-study
#3
Mingwei Wei, Fanyue Meng, Shiyuan Wang, Jingxin Li, Yuntao Zhang, Qunying Mao, Yuemei Hu, Pei Liu, Nianmin Shi, Hong Tao, Kai Chu, Yuxiao Wang, Zhenglun Liang, Xiuling Li, Fengcai Zhu
BACKGROUND:  This study evaluated the 2-year efficacy, immunogenicity, and safety of the Vigoo enterovirus 71 (EV71) vaccine. METHOD:  In an initial phase 3 study, we randomly assigned healthy infants and children aged 6-35 months (ratio, 1:1) to receive 2 doses of either EV71 vaccine (5120 participants) or placebo (5125 participants) at days 0 and 28, and followed them for 12 months after vaccination. In this extended follow-up study, we continued to evaluate the efficacy, immunogenicity, and safety of the EV71 vaccine for up to 2 years...
January 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28075428/balanced-secretion-of-anti-cea-x-anti-cd3-diabody-chains-using-the-2a-self-cleaving-peptide-maximizes-diabody-assembly-and-tumor-specific-cytotoxicity
#4
K Mølgaard, M Compte, N Nuñez-Prado, S L Harwood, L Sanz, L Alvarez-Vallina
Adoptive transfer of genetically engineered human cells secreting bispecific T cell engagers has shown encouraging therapeutic effects in preclinical models of cancer. However, reducing the toxicity and improving the effectiveness of this emerging immunotherapeutic strategy will be critical to its successful application. We have demonstrated that for gene-based bispecific antibody strategies, two-chain diabodies have a better safety profile than single-chain tandem scFvs, because their reduced tendency to form aggregates reduces the risk of inducing antigen-independent T cell activation...
January 11, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28075416/phosphorylated-radix-cyathulae-officinalis-polysaccharides-act-as-adjuvant-via-promoting-dendritic-cell-maturation
#5
Haibo Feng, Sean P McDonough, Jing Fan, Shiping Yang, Xuelian Zhao, Yong Lu, Yun Gan, Xiao Yi, Yung-Fu Chang
The aim of this study was to investigate whether phosphorylated Radix Cyathulae officinalis Kuan polysaccharides (pRCPS) used as adjuvant with foot-and-mouth disease vaccine (FMDV) can stimulate specific humoral and cellular immune responses in ICR mice. The results demonstrated that pRCPS significantly up-regulated FMDV-specific IgG, IgG1, IgG2b and IgG2a antibody levels and splenocyte proliferation. pRCPS also promoted the killing activities of cytotoxic T lymphocytes (CTL) and natural killer cells (NK). In addition, pRCPS enhanced the expression levels of IL-2, IL-4, and IFN-γ in CD4⁺ T cells and the level of IFN-γ in CD8⁺ T cells...
January 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28073399/enterovirus-71-induces-apoptosis-by-directly-modulating-the-conformational-activation-of-pro-apoptotic-protein-bax
#6
Xiaodong Han, Haolong Cong
Enterovirus 71 (EVA71), a virus of the genus enterovirus in the picornaviridae family, is one of the main causative agents of foot, hand and mouth disease in infected infants and young children. In this study, we report that cells with EVA71 infection exhibit increased levels of cytochrome c release and Caspase-3 activation. EVA71 infection induces the conformational activation of pro-apoptotic protein Bax, and the subsequent formation of oligomers of Bax in mitochondria. Inhibitors that block Caspase-8 activation cannot inhibit apoptosis induced by EVA71 infection...
January 10, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28071799/seroepidemiological-and-phylogenetic-characterisation-of-neurotropic-enteroviruses-in-ireland-2005-2014
#7
Jorge Abboud Guerra, Allison Waters, Alison Kelly, Ursula Morley, Paul O'Reilly, Edwin O'Kelly, Jonathan Dean, Robert Cunney, Piaras O'Lorcain, Suzanne Cotter, Jeff Connell, Joanne O'Gorman, William W Hall, Michael Carr, Cillian F De Gascun
Enteroviruses (EVs) are associated with a broad spectrum of clinical presentation, including aseptic meningitis (AM), encephalitis, hand, foot and mouth disease, acute flaccid paralysis and acute flaccid myelitis. Epidemics occur sporadically and are associated with increased cases of AM in children. The present study describes the seroepidemiological analysis of circulating EVs in Ireland from 2005-2014 and phylogenetic characterisation of echovirus 30 (E-30), enterovirus A71 (EV-A71) and enterovirus D68 (EV-D68)...
January 10, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28069250/the-exposure-response-relationship-between-temperature-and-childhood-hand-foot-and-mouth-disease-a-multicity-study-from-mainland-china
#8
Xiong Xiao, Antonio Gasparrini, Jiao Huang, Qiaohong Liao, Fengfeng Liu, Fei Yin, Hongjie Yu, Xiaosong Li
BACKGROUND: Hand, foot and mouth disease (HFMD) is a rising public health issue in the Asia-Pacific region. Numerous studies have tried to quantify the relationship between meteorological variables and HFMD but with inconsistent results, in particular for temperature. We aimed to characterize the relationship between temperature and HFMD in various locations and to investigate the potential heterogeneity. METHODS: We retrieved the daily series of childhood HFMD counts (aged 0-12 years) and meteorological variables for each of 143 cities in mainland China in the period 2009-2014...
January 6, 2017: Environment International
https://www.readbyqxmd.com/read/28063993/inhibition-of-enterovirus-71-replication-by-an-%C3%AE-hydroxy-nitrile-derivative-nk-1-9k
#9
Yaxin Wang, Lin Cao, Yangyang Zhai, Jiaming Ma, Quandeng Nie, Ting Li, Zheng Yin, Yuna Sun, Luqing Shang
Enterovirus 71 (EV71) is one of the major etiological agents of human hand-foot-and-mouth disease (HFMD) worldwide. EV71 infection in young children and people with immunodeficiency causes severe symptoms with a high fatality rates. However, there is still no approved drugs to treat such infections. Based on our previous report of a peptide-aldehyde anti-EV71 protease, we present here a highly specific α-hydroxy-nitrile derivative NK-1.9k, which inhibited the proliferation of multiple EV71 strains and coxsackievirus A16 (CVA16) in various cells with EC50 of 37...
January 4, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28063653/temporal-and-spatial-analysis-of-hand-foot-and-mouth-disease-in-relation-to-climate-factors-a-study-in-the-mekong-delta-region-vietnam
#10
Huong Xuan Nguyen, Cordia Chu, Huong Lien Thi Nguyen, Ha Thanh Nguyen, Cuong Manh Do, Shannon Rutherford, Dung Phung
This study examined the temporal and spatial patterns of hand, foot, and mouth disease (HFMD) in the Mekong Delta region in Vietnam. A time-series analysis was used to examine the temporal patterns of HFMD in relation to climate factors while a retrospective space-time scan was used to detect the high-risk space-time clusters of this disease. A 1°C increase in average temperature was associated with 5.6% increase in HFMD rate at lag 5days (95% CI 0.3-10.9). A 1% increase in humidity had equal influence of 1...
January 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28059060/-statistics-of-the-activities-of-a-veterinarian-from-the-canton-of-neuch%C3%A3-tel-from-the-19th-century
#11
A Rutti
Abraham Buehler wrote a statistical sketch of his activity as a practitioner during the years 1855 to 1861 in "Les Verrières" in the Swiss Canton of Neuchâtel. He included charts relating to diseases observed in different species such as horses, cows, goats, sheep, pigs and dogs. He described the evolution of the foot and mouth epidemic in the region during the years 1855 and 1856. Abraham Buehler stated that with this work he aimed to encourage his colleagues to also collect data.
January 2017: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/28056277/-direct-medical-costs-and-influencing-factors-in-severe-hand-foot-and-mouth-disease-in-children-aged-between-six-months-and-five-years-old
#12
Y M Zheng, J Yang, Q H Liao
Objective: To estimate the direct medical cost of severe hand, foot and mouth disease (HFMD) in patients aged less than five years. Methods: A stratified sampling method was used to collect data on severe HFMD cases reported in the National HFMD surveillance database between Jan 1, 2012, and Dec 31, 2013. The sampling was referenced with the national aetiologic distribution of Enterovirus A71 (EV-A71), Coxsackievirus A16 (CV-A16) and other Enteroviruses (OEV) for severe HFMD cases and the included cases were distributed among seven geographic regions (Northeast, North China, Northwest, Central China, Southwest, East China and South China)...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28045937/development-of-a-feature-and-template-assisted-assembler-and-application-to-the-analysis-of-a-foot-and-mouth-disease-virus-genotyping-microarray
#13
Roger W Barrette, Jessica M Rowland, Frederic R Grau, Michael T McIntosh
Several RT-PCR and genome sequencing strategies exist for the resolution of Foot-and-Mouth Disease virus (FMDV). While these approaches are relatively straightforward, they can be vulnerable to failure due to the unpredictable nature of FMDV genome sequence variations. Sequence independent single primer amplification (SISPA) followed by genotyping microarray offers an attractive unbiased approach to FMDV characterization. Here we describe a custom FMDV microarray and a companion feature and template-assisted assembler software (FAT-assembler) capable of resolving virus genome sequence using a moderate number of conserved microarray features...
2017: PloS One
https://www.readbyqxmd.com/read/28042848/epidemiologic-features-of-enterovirus-71-associated-hand-foot-and-mouth-disease-from-2009-to-2013-in-zhejiang-china
#14
Zhifang Wang, Huakun Lv, Wenming Zhu, Zhe Mo, Guangming Mao, Xiaofeng Wang, Xiaoming Lou, Yongdi Chen
Enterovirus 71 (EV71) usually causes hand-foot-and-mouth disease (HFMD) with severe clinical symptoms and even deaths in China. There is no efficient antiviral drug to protect against severe EV71-associated HFMD, making the development of EV71 vaccines therefore a priority. However, the potential target subject population(s) to be immunized with EV71 vaccine are not well understood. In this study, we characterized the epidemiology regarding EV71-associated HFMD on the basis of provincial-level surveillance...
December 30, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28040311/foot-and-mouth-disease-vaccines
#15
Fayna Diaz-San Segundo, Gisselle N Medina, Carolina Stenfeldt, Jonathan Arzt, Teresa de Los Santos
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals. The disease affects many areas of the world, often causing extensive epizootics in livestock, mostly farmed cattle and swine, although sheep, goats and many wild species are also susceptible. In countries where food and farm animals are essential for subsistence agriculture, outbreaks of FMD seriously impact food security and development. In highly industrialized developed nations, FMD endemics cause economic and social devastation mainly due to observance of health measures adopted from the World Organization for Animal Health (OIE)...
December 19, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/28039799/adenovirus-vectored-foot-and-mouth-disease-vaccine-confers-early-and-full-protection-against-fmdv-o1-manisa-in-swine
#16
Ignacio Fernandez-Sainz, Gisselle N Medina, Elizabeth Ramirez-Medina, Marla J Koster, Marvin J Grubman, Teresa de Los Santos
A human adenovirus (Ad5) vectored foot-and-mouth disease virus (FMDV) O1-Manisa subunit vaccine (Ad5-O1Man) was engineered to deliver FMDV O1-Manisa capsid and capsid-processing proteins. Swine inoculated with Ad5-O1Man developed an FMDV-specific humoral response as compared to animals inoculated with an empty Ad5-vector. Vaccinated animals were completely protected against homologous challenge at 7 or 21 days post-vaccination. Potency studies exhibited a PD50 of about 10(7) pfu/animal while a dose of 4×10(7)pfu/animal fully protected swine against FMDV intradermal challenge...
December 28, 2016: Virology
https://www.readbyqxmd.com/read/28030850/changes-of-circulating-th22-cells-in-children-with-hand-foot-and-mouth-disease-caused-by-enterovirus-71-infection
#17
Dawei Cui, Fengyun Zhong, Jie Lin, Yidong Wu, Quan Long, Xianzhi Yang, Qiaoyun Zhu, Li Huang, Qifen Mao, Zhaoxia Huo, Zhe Zhou, Guoliang Xie, Shufa Zheng, Fei Yu, Yu Chen
Interleukin (IL)-22+CD4+T (Th22) cells play crucial roles in the pathogenesis of autoimmune diseases and infectious diseases, although the role of Th22 cells remains largely unclear in children with hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71). This study aims to explore the role of circulating IL-22+IL-17A-CD4+T (cTh22) cells in children with EV71-associated HFMD. We found that during the acute stage of illness, the frequencies of cTh22 and circulating IL-22+IL-17A+CD4+T (IL-22+cTh17) cells in CD4+T cells infrom affected patients, and especially in severely affected patients, were significantly higher than in healthy controls (HC)...
December 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/28030650/two-genotypes-of-coxsackievirus-a2-associated-with-hand-foot-and-mouth-disease-circulating-in-china-since-2008
#18
Qian Yang, Yong Zhang, Dongmei Yan, Shuangli Zhu, Dongyan Wang, Tianjiao Ji, Xiaolei Li, Yang Song, Xinrui Gu, Wenbo Xu
Coxsackievirus A2 (CV-A2) has been frequently detected and commonly associated with hand, foot, and mouth disease (HFMD) in China since 2008. However, limited sequences of CV-A2 are currently available. As a result, we have been focusing on the genetic characteristics of CV-A2 in the mainland of China during 2008-2015 based on national HFMD surveillance. In this study, 20 CV-A2 strains were isolated and phylogenetic analyses of the VP1 sequences were performed. Full-length genome sequences of two representative CV-A2 isolates were acquired and similarity plot and bootscanning analyses were performed...
2016: PloS One
https://www.readbyqxmd.com/read/28027826/clinicopathologic-analysis-of-atypical-hand-foot-and-mouth-disease-in-adult-patients
#19
Julie Second, Charles Velter, Sophie Calès, François Truchetet, Dan Lipsker, Bernard Cribier
BACKGROUND: Hand, foot, and mouth disease is a contagious viral infection usually affecting children. A resurgence of cases in adults, mainly caused by coxsackievirus A6 and with an atypical and more severe presentation, has taken place. OBJECTIVE: The goal was to examine the clinical, histologic, and immunohistochemical features of this disease in adults. METHODS: This is a retrospective study on documented cases of adult hand, foot, and mouth disease from France's Dermatology Department of Strasbourg University Hospital and Bel-Air Hospital in Thionville...
December 24, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28002358/an-outbreak-of-kingella-kingae-infections-complicating-a-severe-hand-foot-and-mouth-disease-outbreak-in-nice-france-2016
#20
Nawal El Houmami, Virginie Cointat, Audrey Mirand, Virginie Fouilloux, Janek Bzdrenga, Sofiane Bakour, Philippe Minodier, Marie-Amélie Dubois, Francoise Anave-Frapech, Rémi Charrel, Didier Raoult, Pierre-Edouard Fournier
We report the investigative methods for the diagnosis of an epidemic and culture-negative K. kingae endocarditis complicating a severe outbreak of hand, foot, and mouth disease in a childcare center. The diagnosis was confirmed by PCR testings performed from cardiac tissue. Our findings argue for the systematic investigation of K. kingae outbreaks by using molecular tools in such context.
December 19, 2016: Pediatric Infectious Disease Journal
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