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https://www.readbyqxmd.com/read/29156632/neurotropism-in-vitro-and-mouse-models-of-severe-and-mild-infection-with-clinical-strains-of-enterovirus-71
#1
Pin Yu, Linlin Bao, Lili Xu, Fengdi Li, Qi Lv, Wei Deng, Yanfeng Xu, Chuan Qin
Enterovirus 71 (EV71) is a common etiological agent of hand, foot, and mouth disease and fatal neurological diseases in children. The neuropathogenicity of severe EV71 infection has been documented, but studies comparing mouse models of severe and mild EV71 infection are lacking. The aim of the study was to investigate the neurovirulence of EV71 strains and the differences in serum cytokine and chemokine levels in mouse models of severe and mild EV71 infection. Nine EV71 isolates belonging to the C4 subgenogroup (proposed as genotype D) displayed infectivity in human neuroblastoma SK-N-SH cells; moreover, ultrastructural observation confirmed viral particle replication...
November 20, 2017: Viruses
https://www.readbyqxmd.com/read/29144097/simultaneous-occurrence-of-hand-foot-and-mouth-disease-and-pityriasis-rosea
#2
Francesco Drago, Giulia Ciccarese, Margherita Cioni, Lodovica Gariazzo, Aurora Parodi
No abstract text is available yet for this article.
November 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29142122/adaptive-immune-responses-following-senecavirus-a-infection-in-pigs
#3
Mayara F Maggioli, Steve Lawson, Marcelo de Lima, Lok R Joshi, Tatiane C Faccin, Fernando V Bauermann, Diego G Diel
Senecavirus A (SVA), an emerging picornavirus of swine, causes vesicular disease (VD) that is clinically indistinguishable from foot-and-mouth disease (FMD) in pigs. Many aspects of SVA interactions with the host and the host immune responses to infection, however, remain unknown. In the present study, humoral and cellular immune responses to SVA were evaluated following infection in pigs. We show that SVA infection elicited an early and robust neutralizing antibody (NA) response, which coincided with and was strongly correlated with VP2- and VP3-specific IgM responses...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29129453/hepatitis-b-virus-core-particles-containing-multiple-epitopes-confer-protection-against-enterovirus-71-and-coxsackievirus-a16-infection-in-mice
#4
Chunling Huo, Jie Yang, Lei Lei, Lei Qiao, Jiantao Xin, Zishu Pan
Human enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the two major causative agents of hand-foot-and-mouth disease (HFMD). To investigate novel combined vaccines to prevent EV71 and CA16 infection, we constructed chimeric virus-like particles (tHBc/SPA or tHBc/SP VLPs) displaying conserved epitopes of EV71 (aa 208-222 of VP1 and aa 248-263 of VP2) and CA16 (aa271-285 of VP1) using a truncated hepatitis B virus core carrier (tHBc). Immunization with the chimeric VLPs induced epitope- or virus-specific IgG and neutralization antibodies against EV71 and CA16 in the mice...
November 9, 2017: Vaccine
https://www.readbyqxmd.com/read/29129452/long-term-humoral-immunity-induced-by-cvc1302-adjuvanted-serotype-o-foot-and-mouth-disease-inactivated-vaccine-correlates-with-promoted-t-follicular-helper-cells-and-thus-germinal-center-responses-in-mice
#5
Luping Du, Jin Chen, Liting Hou, Xiaoming Yu, Qisheng Zheng, Jibo Hou
Long-lasting humoral immunity is one of the necessary criteria for a successful vaccine. In our previous study, it was demonstrated that the immunopotentiator CVC1302 could improve the humoral immunity induced by the foot and mouth disease virus (FMDV) killed vaccine (KV) with only one dose. Significantly higher FMDV-specific antibody titers and more persistent antibody responses were observed in pigs receiving CVC1302-adjuvanted KV (KV-CVC1302) than in those inoculated with KV alone. In this study, we show that CVC1302 enhances murine IgG responses to FMDV by promoting a potent T follicular helper cell (TFH) response, which directly controls the magnitude of the germinal center (GC) B cell response...
November 9, 2017: Vaccine
https://www.readbyqxmd.com/read/29125698/engineering-potato-virus-x-particles-for-a-covalent-protein-based-attachment-of-enzymes
#6
Juliane Röder, Rainer Fischer, Ulrich Commandeur
Plant virus nanoparticles are often used to display functional amino acids or small peptides, thus serving as building blocks in application areas as diverse as nanoelectronics, bioimaging, vaccination, drug delivery, and bone differentiation. This is most easily achieved by expressing coat protein fusions, but the assembly of the corresponding virus particles can be hampered by factors such as the fusion protein size, amino acid composition, and post-translational modifications. Size constraints can be overcome by using the Foot and mouth disease virus 2A sequence, but the compositional limitations cannot be avoided without the introduction of time-consuming chemical modifications...
November 10, 2017: Small
https://www.readbyqxmd.com/read/29124905/rapid-and-simple-detection-of-foot-and-mouth-disease-virus-evaluation-of-a-cartridge-based-molecular-detection-system-for-use-in-basic-laboratories
#7
K V Goller, V Dill, M Madi, P Martin, Y Van der Stede, V Vandenberge, B Haas, S Van Borm, F Koenen, C J Kasanga, N Ndusilo, M Beer, L Liu, V Mioulet, B Armson, D P King, V L Fowler
Highly contagious transboundary animal diseases such as foot-and-mouth disease (FMD) are major threats to the productivity of farm animals. To limit the impact of outbreaks and to take efficient steps towards a timely control and eradication of the disease, rapid and reliable diagnostic systems are of utmost importance. Confirmatory diagnostic assays are typically performed by experienced operators in specialized laboratories, and access to this capability is often limited in the developing countries with the highest disease burden...
November 9, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29122876/genome-sequence-of-foot-and-mouth-disease-virus-of-serotype-o-lineage-ind-2001d-isolated-from-cattle-in-mongolia-in-2015
#8
Tatsuya Nishi, Gerelmaa Ulziibat, Buyantogtokh Khanui, Odonchimeg Myagmarsuren, Kazuki Morioka, Makoto Yamakawa, Katsuhiko Fukai
We report the whole-genome sequence of the foot-and-mouth disease virus (FMDV) O/MOG/BU/2-7/2015 isolated in Mongolia in 2015. This virus is closely related to isolates identified in Southeast Asia in 2015 and is classified under the O/ME-SA/Ind-2001d lineage. This is the first detection of an FMDV of this lineage in Mongolia.
November 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29120300/enterovirus-71-antagonizes-the-antiviral-activity-of-host-stat3-and-il-6r-with-partial-dependence-on-virus-induced-mir-124
#9
Zhangmei Chang, Yan Wang, Liang Bian, Qingqing Liu, Jian-Er Long
Enterovirus 71 (EV71) has caused major outbreaks of hand, foot and mouth disease. EV71 infections increase the production of many host cytokines and pro-inflammatory factors, including interleukin (IL)-6, IL-10 and COX-2. Some of these molecules could stimulate the signal transducer and activator of transcription 3 (STAT3), which plays a key role in regulating host immune responses and several viral diseases. However, the role of STAT3 in EV71 infection remains unknown. This study found that the phosphorylation levels of STAT3 (p(Y705)-STAT3) are closely related to EV71 infection...
November 9, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29119112/expression-and-immunogenicity-of-two-recombinant-fusion-proteins-comprising-foot-and-mouth-disease-virus-structural-protein-vp1-and-dc-sign-binding-glycoproteins
#10
Xinsheng Liu, Jianliang Lv, Yuzhen Fang, Peng Zhou, Yanzhen Lu, Li Pan, Zhongwang Zhang, Junwu Ma, Yongguang Zhang, Yonglu Wang
Improving vaccine immunogenicity by targeting antigens to dendritic cells has recently emerged as a new design strategy in vaccine development. In this study, the VP1 gene of foot-and-mouth disease virus (FMDV) serotype A was fused with the gene encoding human immunodeficiency virus (HIV) membrane glycoprotein gp120 or C2-V3 domain of hepatitis C virus (HCV) envelope glycoprotein E2, both of which are DC-SIGN-binding glycoproteins. After codon optimization, the VP1 protein and the two recombinant VP1-gp120 and VP1-E2 fusion proteins were expressed in Sf9 insect cells using the insect cell-baculovirus expression system...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29113733/development-and-evaluation-of-a-novel-real-time-rt-pcr-to-detect-foot-and-mouth-disease-viruses-from-the-emerging-a-asia-g-vii-lineage
#11
Meruyert A Saduakassova, Akhmetzhan A Sultanov, Lespek B Kutumbetov, Jemma Wadsworth, Britta A Wood, Nick J Knowles, Donald P King, Katarzyna Bachanek-Bankowska
A new lineage of foot-and-mouth disease virus (FMDV), called A/ASIA/G-VII, emerged from the Indian subcontinent in 2015 and continues to spread in Western Asia. Currently, the distribution of viruses belonging to this lineage is defined using sequencing approaches, but other cheaper and faster diagnostic methods are urgently needed. Thus, this study describes the development and validation of a novel A/ASIA/G-VII lineage-specific real-time RT-PCR (rRT-PCR). Diagnostic sensitivity and specificity were evaluated using representative field specimens and isolates from the A/ASIA/G-VII lineage, as well as samples comprising other FMDV lineages that co-circulate in Asia (n=54)...
November 4, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/29113363/involvement-of-inducible-nitric-oxide-synthase-and-mitochondrial-dysfunction-in-the-pathogenesis-of-enterovirus-71-infection
#12
Dejian Dang, Chao Zhang, Rongguang Zhang, Weidong Wu, Shuaiyin Chen, Jingchao Ren, Peng Zhang, Guangyuan Zhou, Demin Feng, Tiantian Sun, Ying Li, Qiaoli Liu, Mengchen Li, Yuanlin Xi, Yuefei Jin, Guangcai Duan
Enterovirus71 (EV71) is recognized as the main causative agent of severe hand, foot and mouth disease (HFMD). However, the pathogenesis of EV71 infection has not been well characterized. Clinical evidence indicated that inducible nitric oxide synthase (iNOS) induction in the lung of HFMD patients contributes to the severe symptoms of pulmonary edema. In the present study, we recruited 142 subjects including HFMD patients and controls, and serum level of nitric oxide (NO) was determined. Next, cellular and animal model were used to further investigate the roles of iNOS and mitochondria damage during EV71 infection...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108665/evaluation-of-a-polyvalent-foot-and-mouth-disease-virus-vaccine-containing-a-saudi-95-against-field-challenge-on-large-scale-dairy-farms-in-saudi-arabia-with-the-emerging-a-asia-g-vii-viral-lineage
#13
Nicholas A Lyons, Anna B Ludi, Ginette Wilsden, Pip Hamblin, Ibrahim Ahmed Qasim, Simon Gubbins, Donald P King
In 2015, foot-and-mouth disease (FMD) viruses of the A/ASIA/G-VII lineage emerged from the Indian sub-continent to cause outbreaks in the Middle and Near East. A factor which has been proposed to have contributed to the rapid spread of this lineage is the poor in vitro vaccine-match of field isolates to vaccine strains that are commonly used in the region. This study used data from outbreaks on four large-scale dairy farms using routine vaccination in Saudi Arabia, to evaluate the impact of vaccination and learn how to manage outbreaks more effectively in this setting...
November 3, 2017: Vaccine
https://www.readbyqxmd.com/read/29108321/association-study-of-inflammatory-cytokine-and-chemokine-expression-in-hand-foot-and-mouth-disease
#14
Wenzhong Shang, Suying Qian, Lijuan Fang, Yong Han, Cuiping Zheng
Objective: To determine the relationship of cytokine/chemokine expression with the clinical presentation of hand, foot and mouth disease (HFMD). Results: All cytokine/chemokine levels were higher in severe HFMD patients than in mild HFMD patients or controls (P < 0.01). RANTES, MCP-1, IL-4, IL-12 and IL-18 levels were higher in mild HFMD patients than in the controls (P < 0.05). In severe HFMD, all levels (except IL-8 and IL-4) were higher in patients with encephalitis plus pulmonary edema than in those with encephalitis alone (P < 0...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29103677/enhanced-protection-against-fmdv-in-cattle-after-prime-boost-vaccination-based-on-mucosal-and-inactivated-fmd-vaccine
#15
Manar E Khalifa, Ayman H El-Deeb, Sayed M Zeidan, Hussein A Hussein, Hany I Abu-El-Naga
Improved immunization and control strategies and platforms are greatly needed for foot and mouth disease virus (FMDV) and mucosal vaccines propose an effective strategy for the control FMDV by blocking viral entry. In this study, several immunization strategies, using two FMDV vaccine formulations, including Montanide ISA 206 oil-based FMD inactivated vaccine and Montanide IMS 1313 VG N PR-based concentrated semi-purified FMD mucosal vaccine, were applied. Results of intranasal immunization with the prepared FMD mucosal vaccine, given once or twice, induced IgA levels in both nasal and salivary secretions besides a high response of lymphocyte proliferation with protection levels reaching 20% and 40%, respectively, in a challenge trial in cattle...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29102329/genetic-and-antigenic-characterization-of-serotype-o-fmd-viruses-from-east-africa-for-the-selection-of-suitable-vaccine-strain
#16
Katie Lloyd-Jones, Mana Mahapatra, Sasmita Upadhyaya, David J Paton, Aravindh Babu, Geoff Hutchings, Satya Parida
Foot-and-mouth disease (FMD) is endemic in Eastern Africa with circulation of multiple serotypes of the virus in the region. Most of the outbreaks are caused by serotype O followed by serotype A. The lack of concerted FMD control programmes in Africa has provided little incentive for vaccine producers to select vaccines that are tailored to circulating regional isolates creating further negative feedback to deter the introduction of vaccine-based control schemes. In this study a total of 80 serotype O FMD viruses (FMDV) isolated from 1993 to 2012 from East and North Africa were characterized by virus neutralisation tests using bovine antisera to three existing (O/KEN/77/78, O/Manisa and O/PanAsia-2) and three putative (O/EA/2002, O/EA/2009 and O/EA/2010) vaccine strains and by capsid sequencing...
November 1, 2017: Vaccine
https://www.readbyqxmd.com/read/29095779/onychomadesis-as-a-late-complication-of-hand-foot-mouth-disease-a-case-series-shedding-light-on-nail-shedding
#17
Nicholas A Kuehnel, Sokunthirith Thach, Danny G Thomas
Hand-foot-mouth disease is a viral illness frequently caused by enterovirus and coxsackievirus. Traditionally, this disease initially causes malaise, fever, and rash with vesicles in the mouth, as well as on the hands and feet. Occasionally, more severe presentations and late postinfectious sequelae occur, including onychomadesis, nail matrix arrest. We describe a series of 4 cases of onychomadesis and its evaluation following recent hand-foot-mouth disease during this current enteroviral season as a way to ensure appropriate clinician diagnosis and guidance...
November 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29093091/a-3-0-angstrom-resolution-cryo-electron-microscopy-structure-and-antigenic-sites-of-coxsackievirus-a6-like-particles
#18
Jinhuan Chen, Chao Zhang, Yu Zhou, Xiang Zhang, Chaoyun Shen, Xiaohua Ye, Wen Jiang, Zhong Huang, Yao Cong
Coxsackievirus A6 (CVA6) has recently emerged as one of the predominant causative agents of hand, foot, and mouth disease (HFMD). Structure of CVA6 mature viral particle has not been solved thus far. Our previous work shows that recombinant virus-like particles (VLPs) of CVA6 represent a promising CVA6 vaccine candidate. Here, we report the first cryo-electron microscopy (cryo-EM) structure of CVA6 VLP at 3.0 Å resolution. CVA6 VLP exhibits the characteristic features of enteroviruses, but presents an open channel at the two-fold axis and an empty, collapsed VP1 pocket, which is broadly similar to the structures of enterovirus 71 (EV71) VLP and coxsackievirus A16 (CVA16) 135S expanded particle, indicating that CVA6 VLP is in an expanded conformation...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29081918/seroprevalence-and-risk-factors-for-peste-des-petits-ruminants-and-selected-differential-diagnosis-in-sheep-and-goats-in-tanzania
#19
Emeli Torsson, Mikael Berg, Gerald Misinzo, Ida Herbe, Tebogo Kgotlele, Malin Päärni, Nils Roos, Anne-Lie Blomström, Karl Ståhl, Jonas Johansson Wensman
Introduction: Livestock husbandry is critical for food security and poverty reduction in a low-income country like Tanzania. Infectious disease is one of the major constraints reducing the productivity in this sector. Peste des petits ruminants (PPR) is one of the most important diseases affecting small ruminants, but other infectious diseases may also be present. Objective: The objective of this study was to determine the seroprevalence and risk factors for exposure to PPR, contagious caprine pleuropneumonia (CCPP), foot-and-mouth disease (FMD), bluetongue (BT), and bovine viral diarrhoea (BVD) in sheep and goats in Tanzania...
2017: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/29076657/safety-profile-of-a-replication-deficient-human-adenovirus-vectored-foot-and-mouth-disease-virus-serotype-a24-subunit-vaccine-in-cattle
#20
J Barrera, D A Brake, B J Kamicker, C Purcell, R Kaptur, T Schieber, K Lechtenberg, T D Miller, D Ettyreddy, D E Brough, B T Butman, M Colby, J G Neilan
The safety of a replication-deficient, human adenovirus-vectored foot-and-mouth disease virus (FMDV) serotype A24 Cruzeiro capsid-based subunit vaccine (AdtA24) was evaluated in five independent safety studies. The target animal safety studies were designed in compliance with United States (U.S.) regulatory requirements (Title 9, U.S. Code of Federal Regulation [9CFR]) and international standard guidelines (VICH Topic GL-44) for veterinary live vaccines. The first three studies were conducted in a total of 22 vaccinees and demonstrated that the AdtA24 master seed virus (MSV) was safe, did not revert to virulence and was not shed or spread from vaccinees to susceptible cattle or pigs...
October 27, 2017: Transboundary and Emerging Diseases
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