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Foot mouth disease

Annebel R De Vleeschauwer, Xiaocui Zhou, David J Lefebvre, Annabelle Garnier, Fleur Watier, Charly Pignon, Sandrine A Lacour, Stephan Zientara, Labib Bakkali-Kassimi, Kris De Clercq, Bernard Klonjkowski
Vaccination is a key element in the control of foot-and-mouth disease (FMD). The majority of the antigenic sites that induce protective immune responses are localized on the FMD virus (FMDV) capsid that is formed by four virus-encoded structural proteins, VP1 to VP4. In the present study, recombinant canine adenovirus type 2 (CAV2)-based FMD vaccines, Cav-P1/3C R° and Cav-VP1 R°, respectively expressing the structural P1 precursor protein along with the non-structural 3C protein or expressing the structural VP1 protein of the FMDV strain O/FRA/1/2001, were evaluated as novel vaccines against FMD...
March 12, 2018: Vaccine
Teresa de Los Santos, Fayna Diaz-San Segundo, Luis L Rodriguez
Foot-and-mouth disease (FMD) continues to be the viral disease posing the greatest economic threat to agriculture. An unusually fast replication rate, extreme transmissibility, broad species tropism and antigenic diversity have made its etiologic agent, FMD virus, a difficult pathogen to defeat. Over the last 70 years, use of an inactivated virus vaccine has played a key role in disease control and eradication was possible in certain regions of the world. However, a rapidly changing environment, increased trade, population growth, international travel and migration, contribute to disease resurgence, challenging the capabilities of any available vaccine...
March 12, 2018: Current Opinion in Virology
S K Abdrakhmanov, S B Tyulegenov, F I Korennoy, A A Sultanov, I I Sytnik, K K Beisembaev, A A Bainiyazov, A E Munsey, A M Perez, K VanderWaal
Foot-and-mouth disease (FMD) poses a significant obstacle to international trade and economic development, and for that reason, FMD prevention, control and eradication are major goals guiding animal health policy in most countries. The purpose of this study was to conduct a retrospective spatiotemporal analysis of FMD outbreaks among livestock in the Republic of Kazakhstan (RK) from 1955 to 2013. During that time, several FMD control strategies were implemented in RK, which culminated with the World Organization for Animal Health (OIE) recognition of RK as a country that is FMD-free with partial vaccination (2015)...
March 15, 2018: Transboundary and Emerging Diseases
Cecilia M Lotufo, Maximiliano Wilda, Adrian N Giraldez, Pablo R Grigera, Nora M Mattion
A foot-and-mouth disease virus (FMDV) DNA-launched reporter replicon containing a luciferase gene was used to assess the impact of non-structural (NS) protein 3A on viral replication. Independent deletions within the N-terminal region (amino acid [aa] residues 6 to 24) and the central hydrophobic region (HR, aa 59 to 76) of FMDV NS protein 3A were engineered, and luciferase activity in lysates of control and mutated replicon-transfected cells was measured. Triple alanine replacements of the N-terminal triplet Arg 18- His 19 -Glu 20 and a single alanine substitution of the highly charged Glu 20 residue both resulted in a 70-80% reduction in luciferase activity when compared with wild-type controls...
March 13, 2018: Archives of Virology
Dinh Bao Truong, Flavie Luce Goutard, Stéphane Bertagnoli, Alexis Delabouglise, Vladimir Grosbois, Marisa Peyre
This study aimed to analyze the financial impact of foot-and-mouth disease (FMD) outbreaks in cattle at the farm-level and the benefit-cost ratio (BCR) of biannual vaccination strategy to prevent and eradicate FMD for cattle in South Vietnam. Production data were collected from 49 small-scale dairy farms, 15 large-scale dairy farms, and 249 beef farms of Long An and Tay Ninh province using a questionaire. Financial data of FMD impacts were collected using participatory tools in 37 villages of Long An province...
2018: Frontiers in Veterinary Science
Lipsa Dash, Saravanan Subramaniam, Sagar A Khulape, Bikash Ranjan Prusty, Kamal Pargai, Shirish D Narnaware, Niteen V Patil, Bramhadev Pattnaik
Foot-and-mouth disease (FMD) is an acute, highly contagious, and economically devastating viral disease of domestic and wildlife species. For effective implementation of FMD control program, there is an imperative need for developing a rapid, sensitive, and specific diagnostics which help in the identification of serotypes involved in the outbreaks. The humoral immune response of the Camelidae is unique since in these animals 75% of circulating antibodies are constituted by heavy-chain antibodies and 25% are conventional immunoglobulin with two identical heavy chains...
March 12, 2018: Animal Biotechnology
T Xu, Z Lin, C H Wang, Y Li, M Zhao, L Hua, B Zhu
There is still no effective clinical antiviral drug against human enterovirus 71 (EV71) infection, which causes hand, foot and mouth disease (HFMD) in children. Scavenger receptor class B member 2 (SCARB2) is an important receptor of EV71 as it plays a vital role in the early steps of viral infection. In this study, recombinant SCARB2 protein was expressed and purified in a prokaryotic expression system, and was identified by western blot with a monoclonal antibody and mass spectrometry analysis. Detection of the sera from mice immunized with the recombinant SCARB2 protein using ELISA and western blot showed good immunogenicity of the recombinant protein...
2018: Acta Virologica
Waqas Ali, Mudasser Habib, Rai Shafqat Ali Khan, Muhammad Ashir Zia, Muhammad Farooq, Sanaullah Sajid, Muhammad Salah Ud Din Shah
This study reports the molecular characterization of foot-and-mouth disease virus (FMDV) in the provinces of Punjab and Sindh, Pakistan during 2014-17. FMDV genome was detected in 42 and 41 out of 46 samples (epithelial tissue and saliva) by reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) and reverse transcriptase polymerase chain reaction (RT-PCR), respectively. Sequences of the complete VP1 coding region of the samples (n = 33) was achieved showing that 10, 4 and 19 samples belonged to serotype O, A and Asia1 respectively...
March 7, 2018: Archives of Virology
Jingjing Yuan, Li Shen, Jing Wu, Xinran Zou, Jiaqi Gu, Jianguo Chen, Lingxiang Mao
Enterovirus A71 (EV-A71) infection has grown to become a serious threat to global public health. It is one of the major causes of hand, foot, and mouth disease (HFMD) in infants and young children. EV-A71 can also infect the central nervous system (CNS) and induce diverse neurological complications, such as brainstem encephalitis, aseptic meningitis, and acute flaccid paralysis, or even death. Viral proteins play a crucial role in EV-A71 infection. Many recent studies have discussed the structure and function of EV-A71 proteins, and the findings reported will definitely aid the development of vaccines and therapeutic approaches...
2018: Frontiers in Microbiology
Manabu Yamada, Katsuhiko Fukai, Kazuki Morioka, Tatsuya Nishi, Reiko Yamazoe, Rie Kitano, Nobuaki Shimada, Kazuo Yoshida, Toru Kanno, Kenichi Sakamoto, Makoto Yamakawa
We examined the histological distribution of the lesions and the viral antigen associated with the virus and virus RNA in multisystemic organs in the early stages of foot-and-mouth disease virus (FMDV) O/JPN/2010 infection in pigs. Characteristic lesions commonly observed in pigs with FMD arise following inoculation with 106 tissue culture infectious dose (TCID)50 /ml of FMDV O/JPN/2010 in pigs at 3 days post inoculation (dpi) by a natural infectious route. However, none of the six pigs inoculated with 103 TCID50 /ml of FMDV O/JPN/2010 showed any evidence of infection up to 6 dpi...
March 6, 2018: Journal of Veterinary Medical Science
Fiona Mei Shan Teo, Min Nyo, Anng Anng Wong, Natalie Woon Hui Tan, Mia Tuang Koh, Yoke Fun Chan, Chia Yin Chong, Justin Jang Hann Chu
Hand, foot and mouth disease (HFMD) is a prevalent contagious childhood disease typically associated with fever, oral lesions and limb exanthema. While HFMD is caused by a plethora of serotypes of viruses under the genus Enterovirus within the Picornaviridae family, Coxsackievirus A16 (CV-A16) and Enterovirus 71 (EV-A71) are considered the main etiological agents. In recent years however, other viruses have also been isolated in considerable numbers from infected individuals in many regions, joining the legion commonly associated with HFMD...
March 6, 2018: Scientific Reports
Laure Mouton, Aldo Dekker, Meindert Bleijenberg, Michel Blanchet, Jose Coco-Martin, Pascal Hudelet, Sylvain Goutebroze
FMDV serotype SAT2 is most frequently associated with outbreaks in ruminants. However, the risk of it spreading from cattle to pigs cannot be excluded. To assess the efficacy of an SAT2-type FMD inactivated vaccine against homologous challenge in pigs, a suitable challenge strain adapted to pigs was produced. After two passages in two pigs each, a FMDV stock of SAT2 challenge strain was produced. This material was used to infect two groups of five pigs. The first group being vaccinated 28 days before challenge and the other one left as an unvaccinated control...
March 3, 2018: Vaccine
B Souley Kouato, E Thys, V Renault, E Abatih, H Marichatou, S Issa, C Saegerman
Foot-and-mouth disease (FMD) is endemic in Niger, with outbreaks occurring every year. Recently, there was an increasing interest from veterinary authorities to implement preventive and control measures against FMD. However, for an efficient control, improving the current knowledge on the disease dynamics and factors related to FMD occurrence is a prerequisite. The objective of this study was therefore to obtain insights into the incidence and the spatio-temporal patterns of transmission of FMD outbreaks in Niger based on the retrospective analysis of 9-year outbreak data...
March 5, 2018: Transboundary and Emerging Diseases
Regina Fölster-Holst
No abstract text is available yet for this article.
March 6, 2018: Acta Dermato-venereologica
Ryan Waters, Anna B Ludi, Veronica L Fowler, Ginette Wilsden, Clare Browning, Simon Gubbins, Bob Statham, Abdelghani Bin-Tarif, Valerie Mioulet, David J King, Claire Colenutt, Emma Brown, Pascal Hudelet, Donald P King
In 2015, outbreaks of foot-and-mouth disease (FMD) in the Middle East were discovered to be caused by a viral lineage (A/ASIA/G-VII), which has recently emerged from the Indian sub-continent. In vitro vaccine matching data generated by the World Reference Laboratory (WRLFMD) indicated that A/ASIA/G-VII field viruses were poorly matched with vaccines (A-SAU-95, A22 IRQ and A-IRN-05) that are already used in the region. In order to assess the likely performance of one of these commercially available FMD vaccines, sixteen cattle were vaccinated with a polyvalent vaccine which contained two serotype A components (A-SAU-95 and A-IRN-05) with a homologous potency of at least 6PD50 , and two cattle were left unvaccinated as controls...
March 2, 2018: Vaccine
Yuwei Yang, Enqing You, Jinju Wu, Wenyan Zhang, Jin Jin, Mengmeng Zhou, Chunxiao Jiang, Fen Huang
BACKGROUND: In recent years, hand, foot, and mouth disease (HFMD) has become a major public health issue in China, and its reinfection rate has been high. Numerous studies have examined the effects of meteorological factors involved in HFMD infection. However, no study has investigated the effects on HFMD reinfection. The present study analyzed the relationship between relative humidity and HFMD reinfection. METHODS: We employed a distributed lag nonlinear model to evaluate the relationship between relative humidity and childhood HFMD reinfection in Hefei, China during 2011-2016...
February 27, 2018: Science of the Total Environment
Xiaoying Zhi, Jianliang Lv, Yanquan Wei, Yuan Gao, Ping Du, Yanyan Chang, Yun Zhang, Run Wu, Huichen Guo
No abstract text is available yet for this article.
February 28, 2018: Canadian Journal of Microbiology
David W Shanafelt, C Perrings
The 2001 UK foot and mouth disease (FMD) epidemic marked a change in global FMD management, focusing less on trade isolation than on biosecurity within countries where FMD is endemic. Post 2001 policy calls for the isolation of disease-free zones in FMD-endemic countries, while increasing the opportunities for trade. The impact of the change on disease risk has yet to be tested. In this paper, we estimate an empirical model of disease risk that tests for the impact of trade volumes before and after 2001, controlling for biosecurity measures...
February 27, 2018: EcoHealth
Qiuting Fu, Qiankun Cui, Yi Yang, Xinghong Zhao, Xu Song, Guangxi Wang, Lu Bai, Shufan Chen, Ye Tian, Yuanfeng Zou, Lixia Li, Guizhou Yue, Renyong Jia, Zhongqiong Yin
Resveratrol, a polyphenolic plant antitoxin, has a wide range of pharmacological activities. In this study, we systematically evaluated the effects of resveratrol dry suspension (RDS) on immune function in piglets that were treated with different doses of RDS for 2 weeks. The results showed that the RDS has significant effects on the development, maturation, proliferation, and transformation of T lymphocytes. RDS could regulate humoral immune responses by upregulating the release of IFN- γ and downregulating the release of TNF- α ...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Florencia Barrionuevo, Sebastián Di Giacomo, Danilo Bucafusco, Andrea Ayude, Juan Schammas, M Cruz Miraglia, Alejandra Capozzo, Manuel V Borca, Mariano Perez-Filgueira
The role of passively transferred sera in the protection against aerogenous foot-and-mouth disease (FMD) virus infection in cattle was evaluated using vaccine-induced immune serum preparations obtained at 7 and 26 days post-vaccination (dpv). We showed that circulating antibodies were sufficient to prevent disease generalization after oronasal infection in animals passively transferred with 26-dpv serum but not with the 7-dpv serum. Conversely, conventional FMD vaccination provided clinical protection at 7 dpv, promoting fast and robust antibody responses upon challenge and even though antibody titers were similar to those found in animals passively immunized with 7-dpv serum...
February 23, 2018: Virology
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