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https://www.readbyqxmd.com/read/28654898/effect-of-long-non-coding-rna-highly-up-regulated-in-liver-cancer-hulc-on-the-prognosis-of-cancer-a-meta-analysis
#1
Yong Li, Yi-Hong Liu, Xian Chen, Yan-Juan Zhu, Hai-Bo Zhang, Yan Li, Jian-Ping Bai, Li-Rong Liu, Yan-Chun Qu, Xin Qu
Some studies investigated the association between highly up-regulated in liver cancer (HULC) and the overall survival (OS) of cancer. However, the results were conflicted and inconclusive. Therefore, we performed this meta-analysis to determine the association between HULC and the OS of cancer. A comprehensive online search was conducted on Online electronic databases (PubMed, EMBASE, and Wanfang database) from the earliest date to Aug 30, 2016. The strength of the association was calculated with the HRs and respective 95% CIs...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654795/low-expression-of-long-noncoding-rna-casc2-indicates-a-poor-prognosis-and-promotes-tumorigenesis-in-thyroid-carcinoma
#2
Xiangqing Xiong, Hua Zhu, Xiangjian Chen
Recently, long noncoding RNAs (lncRNAs) have been shown to be linked to regulate different biological processes, such as cell growth, differentiation and tumorigenesis. LncRNAs have been identified to be promising clinical biomarkers in various tumors. Long noncoding RNAs cancer susceptibility candidate 2 (CASC2) has recently been demonstrated to be correlated to tumorigenesis in renal cell carcinoma, lung carcinoma, glioma, and gastric carcinoma. Nevertheless, the research on the biological function and clinical significance of CASC2 in thyroid carcinoma are still unclear...
June 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28654632/p53-and-protein-phosphorylation-regulate-the-oncogenic-role-of-epithelial-cell-transforming-2-ect2
#3
Yan Chen, Ping Tian, Yi Liu
BACKGROUND Gastric cancer (GC) is the second leading cause of cancer-related death worldwide, but little progress has been achieved in the treatment of advanced or metastatic GC. GC is highly heterogeneous and more studies are needed to elucidate the metastatic mechanisms. Epithelial cell transforming 2 (ECT2) has been reported to be up-regulated in GC tissues, but its signaling mechanisms remain unclear. MATERIAL AND METHODS In this study, we used Western blot analysis to compare the expression level of ECT2 in 2 GC cell lines: MKN1 and MKN45...
June 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28653901/gankyrin-promotes-the-proliferation-of-gastric-cancer-and-is-associated-with-chemosensitivity
#4
Yue-Can Zeng, Dan Sun, Wen-Hui Li, Jing Zhao, Yan Xin
Although gankyrin is involved in the tumorigenicity and metastasis of some malignancies, the role of gankyrin in gastric cancer is not clear. In this study, we evaluated the function and mechanism of gankyrin in gastric cancer. The effects of gankyrin on gastric cancer growth, proliferation, and chemosensitivity were determined. Gankyrin expression was significantly increased in gastric cancer compared to non-cancerous tissues. This expression significantly enhanced cancer cell proliferation and growth in vitro and in vivo...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28653886/the-mir-608-rs4919510-polymorphism-may-modify-cancer-susceptibility-based-on-type
#5
Shuangshuang Wu, Weiyan Yuan, Yu Shen, Xiao Lu, Yue Li, Tian Tian, Liying Jiang, Xun Zhuang, Jianqing Wu, Minjie Chu
Previous meta-analysis has not shown different effects of miR-608 rs4919510 polymorphism in specific cancer types and reported no significant association between rs4919510 and cancer risk among Chinese. However, more recent findings have been inconsistent. Therefore, we performed an updated meta-analysis to examine whether this polymorphism is associated with cancer risk based on ethnicity and type. A total of 18 case-control studies, comprising 12,517 cases and 15,624 controls, were included in our study. Surprisingly, in contrast with previous meta-analysis, a significant association between the rs4919510 polymorphism and cancer risk was observed in Chinese (CG vs CC: odds ratio = 1...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28653880/mir-129-5p-influences-the-progression-of-gastric-cancer-cells-through-interacting-with-spock1
#6
Lei Yan, Kai Sun, Yang Liu, Jun Liang, Kerui Cai, Jinqiu Gui
The purpose of our study is to clarify the effect of microRNA-129-5p in the progression of human gastric cancer cells by regulating SPOCK1. The expression of microRNA-129-5p and SPOCK1 was tested by quantitative real-time polymerase chain reaction in tissues and cell lines. We validated the targeted relationship between microRNA-129-5p and SPOCK1 by dual luciferase reporter gene assay. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, colony formation, flow cytometry, transwell, and wound scratch assays were used to analyze the effects of microRNA-129-5p on SGC-7901 cell viability, proliferation, cell cycle and apoptosis, invasiveness, and migration...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28653172/a-cis-eqtl-genetic-variant-of-the-cancer-testis-gene-ccdc116-is-associated-with-risk-of-multiple-cancers
#7
Na Qin, Cheng Wang, Qun Lu, Tongtong Huang, Meng Zhu, Lihua Wang, Fei Yu, Mingtao Huang, Yue Jiang, Juncheng Dai, Hongxia Ma, Guangfu Jin, Chen Wu, Dongxin Lin, Hongbing Shen, Zhibin Hu
Recent studies have found that cancer-testis (CT) genes, which are expressed predominantly in germ and cancer cells, may be candidate cancer drivers. Because of their crucial roles, genetic variants in these genes may contribute to the development of cancer. Here, we systematically evaluated associations of common variants in CT genes and their promoters for the risk of lung cancer in our initial GWAS (2331 cases and 3077 controls), followed by in silico replication using additional 10,512 lung cancer cases and 9562 controls...
June 26, 2017: Human Genetics
https://www.readbyqxmd.com/read/28652775/wwc3-downregulation-correlates-with-poor-prognosis-and-inhibition-of-hippo-signaling-in-human-gastric-cancer
#8
Jiabin Hou, Jin Zhou
The aim of this study was to investigate the clinicopathological significance and biological roles of WWC3 in human gastric cancer (GC). Clinical significance of WWC3 in human GCs was examined by using immunohistochemistry (IHC). WWC3 was downregulated in 48 of 111 human GCs, and its downregulation was associated with advanced stage, positive nodal status, and higher relapse rate. Importantly, WWC3 downregulation correlated with poor survival. It was also found that WWC3 protein expression was downregulated in GC cell lines compared with normal cell line GES-1...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28652767/prognostic-value-of-high-imp3-expression-in-solid-tumors-a-meta-analysis
#9
Luyao Chen, Yongpeng Xie, Xintao Li, Liangyou Gu, Yu Gao, Lu Tang, Jianwen Chen, Xu Zhang
BACKGROUND: Accumulated studies have investigated the prognostic role of insulin-like growth factor II mRNA-binding protein 3 (IMP3) in various cancers, but inconsistent and controversial results were obtained. Therefore, we performed a systematic review and meta-analysis to investigate the potential value of IMP3 in the prognostic prediction of human solid tumors. MATERIALS AND METHODS: A systematic literature search in the electronic databases PubMed, Embase, Web of Science, and Cochrane library (updated to April 2016) was conducted to identify eligible studies...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28652651/molecular-mimicry-in-helicobacter-pylori-infections
#10
REVIEW
Magdalena Chmiela, Weronika Gonciarz
Gram-negative bacteria Helicobacter pylori (H. pylori) colonize gastric mucosa in humans and increase the risk of serious diseases such as gastric and duodenal ulcers, stomach cancers and mucosa associated lymphoid tissue lymphoma. The role of H. pylori infection in the pathogenesis of several extragastric diseases has been suggested including immune thrombocytopenic purpura, iron deficiency anemia, vitamin D deficiency, cardiovascular diseases, diabetes mellitus and dermatological disorders. Also neurological diseases and even lung cancer have attracted researchers concern...
June 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28652452/correlation-between-infection-status-of-epstein-barr-virus-and-18-f-fluorodeoxyglucose-uptake-in-patients-with-advanced-gastric-cancer
#11
Sae Jung Na, Hye Lim Park, Joo Hyun O, Sung Yong Lee, Kyo Young Song, Sung Hoon Kim
BACKGROUND: Epstein-Barr virus-associated gastric cancer (EBVaGC) is one of the four molecular subtypes of gastric cancer, as defined by the classification recently proposed by The Cancer Genome Atlas. We evaluated the correlation between EBV positivity and (18)F-fluorodeoxyglucose ((18)F-FDG) uptake by positron emission tomography/computed tomography (PET/CT) in patients with gastric cancer. MATERIALS AND METHODS: We retrospectively enrolled patients with gastric cancer who underwent pretreatment (18)F-FDG PET/CT and subsequent surgical resection, and then were diagnosed with advanced gastric cancer (pathologic stage ≥T2 with any N stage)...
July 2017: In Vivo
https://www.readbyqxmd.com/read/28652421/clinical-significance-of-inhba-gene-expression-in-patients-with-gastric-cancer-who-receive-curative-resection-followed-by-adjuvant-s-1-chemotherapy
#12
Yusuke Katayama, Takashi Oshima, Kentaro Sakamaki, Toru Aoyama, Tsutomu Sato, Katsuhiko Masudo, Manabu Shiozawa, Takaki Yoshikawa, Yasushi Rino, Toshio Imada, Munetaka Masuda
BACKGROUND: Standard treatment for stage II/III gastric cancer is curative resection followed by adjuvant chemotherapy. However, the five-year survival remains unsatisfactory. Inhibin βA (INHBA) has been reported to be associated with cancer cell proliferation and chemoresistance. PATIENTS AND METHODS: We studied the clinical significance of INHBA gene expression in 134 patients with stage II/III gastric cancer who received adjuvant chemotherapy with S-1. INHBA expression of specimens of cancer tissue and adjacent normal mucosa was measured by quantitative real-time, reverse-transcription polymerase chain reaction (RT-PCR)...
July 2017: In Vivo
https://www.readbyqxmd.com/read/28651500/spry4-it1-a-novel-oncogenic-long-non-coding-rna-in-human-cancers
#13
Jianfa Li, Yincong Chen, Zhicong Chen, Anbang He, Haibiao Xie, Qiaoxiao Zhang, Zhiming Cai, Yuchen Liu, Weiren Huang
Long non-coding RNAs are classified as a kind of RNA, which are longer than 200 nucleotides in length and cannot be translated into proteins. Multiple studies have demonstrated that long non-coding RNAs are involved in various cellular processes, including proliferation, differentiation, cell death, and metastasis. Among numerous long non-coding RNAs, we focus on Sprouty4-Intron 1 (SPRY4-IT1), a well-known long non-coding RNA that is overexpressed in various kinds of tumor tissues and cell lines. Accumulating evidences show that SPRY4-IT1 was dysregulated in various cancers, including melanoma, breast cancer, esophageal squamous cell carcinoma, non-small cell lung cancer, gastric cancer, colon cancer, and hepatocellular carcinoma, and amplification of SPRY4-IT1 was associated with different clinicopathological features of cancer patients...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28651018/meta-analysis-of-mirna-expression-profiles-for-prostate-cancer-recurrence-following-radical-prostatectomy
#14
Elnaz Pashaei, Elham Pashaei, Maryam Ahmady, Mustafa Ozen, Nizamettin Aydin
BACKGROUND: Prostate cancer (PCa) is a leading reason of death in men and the most diagnosed malignancies in the western countries at the present time. After radical prostatectomy (RP), nearly 30% of men develop clinical recurrence with high serum prostate-specific antigen levels. An important challenge in PCa research is to identify effective predictors of tumor recurrence. The molecular alterations in microRNAs are associated with PCa initiation and progression. Several miRNA microarray studies have been conducted in recurrence PCa, but the results vary among different studies...
2017: PloS One
https://www.readbyqxmd.com/read/28650730/yield-of-staging-laparoscopy-for-incurable-factors-in-chinese-patients-with-advanced-gastric-cancer
#15
Jun Huang, Hongliang Luo, Chengliang Zhou, Jianjun Zhan, Xionghui Rao, Gang Zhao, Zhengming Zhu
BACKGROUND: Although the role of staging laparoscopy (SL) in detecting radiologically occult M1 disease has been widely recognized, it is seldom used in China and its clinical value based on Chinese population has been rarely reported. The aim of this study is to identify the yield of SL for Chinese patients with advanced gastric cancer (AGC) and determine the proportions of patients in whom treatment plan is altered. MATERIALS AND METHODS: The clinical data were retrospectively collected from 879 AGC patients who underwent SL without any definite signs of disseminated disease on imaging examination...
June 26, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28650587/the-value-of-n-staging-with-the-positive-lymph-node-ratio-and-splenectomy-for-remnant-gastric-cancer-a-multicenter-retrospective-study
#16
Sang-Yong Son, Seong-Ho Kong, Hye Seong Ahn, Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyuk-Joon Lee, Hyung-Ho Kim, Han-Kwang Yang
BACKGROUND: Surgery for remnant gastric cancer (RGC) frequently fails to obtain the >15 lymph nodes necessary for tumor-node-metastasis (TNM) staging. We aimed to evaluate the utility of the recently developed tumor-ratio-metastasis (TRM) staging system. We also examined the pattern of lymph node metastasis and the role of prophylactic splenectomy in RGC. METHODS: Between May 2003 and December 2012, data from 170 patients who underwent surgery for RGC were retrospectively analyzed...
June 26, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28648602/helicobacter-pylori-does-not-use-spermidine-synthase-to-produce-spermidine
#17
Huawei Zhang, Shannon Wing Ngor Au
Helicobacter pylori is the primary pathogen associated to gastritis and gastric cancer. Growth of H. pylori depends on the availability of spermidine in vivo. Interestingly, the genome of H. pylori contains an incomplete set of genes for the classical pathway of spermidine biosynthesis. It is thus not clear whether some other genes remained in the pathway would have any functions in spermidine biosynthesis. Here, we study spermidine synthase, which is responsible for the final catalytic process in the classical route...
June 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28648576/prior-gastroscopy-and-mortality-in-patients-with-gastric-cancer-a-matched-retrospective-cohort-study
#18
Wai K Leung, Hsiu J Ho, Jaw-Town Lin, Ming-Shiang Wu, Chun-Ying Wu
BACKGROUND & AIMS: The role of prior gastroscopy on outcome of gastric cancer patients remains unknown. This study determines the association between intervals of prior gastroscopy and mortality in patients with gastric cancer. METHODS: We identified 20,066 newly diagnosed gastric cancer patients in the national health insurance database of Taiwan between 2002 and 2007. After excluding gastroscopy performed 6 months before diagnosis of cancer, patients were matched into 3 cohorts according to the intervals of prior gastroscopy: 6 months to 2 years (<2Y cohort), 2 to 5 years (2-5Y cohort), and none within recent 5 years (>5Y cohort)...
June 22, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28648364/differentiation-of-human-pluripotent-stem-cells-into-colonic-organoids-via-transient-activation-of-bmp-signaling
#19
Jorge O Múnera, Nambirajan Sundaram, Scott A Rankin, David Hill, Carey Watson, Maxime Mahe, Jefferson E Vallance, Noah F Shroyer, Katie L Sinagoga, Adrian Zarzoso-Lacoste, Jonathan R Hudson, Jonathan C Howell, Praneet Chatuvedi, Jason R Spence, John M Shannon, Aaron M Zorn, Michael A Helmrath, James M Wells
Gastric and small intestinal organoids differentiated from human pluripotent stem cells (hPSCs) have revolutionized the study of gastrointestinal development and disease. Distal gut tissues such as cecum and colon, however, have proved considerably more challenging to derive in vitro. Here we report the differentiation of human colonic organoids (HCOs) from hPSCs. We found that BMP signaling is required to establish a posterior SATB2+ domain in developing and postnatal intestinal epithelium. Brief activation of BMP signaling is sufficient to activate a posterior HOX code and direct hPSC-derived gut tube cultures into HCOs...
June 20, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28648145/er-membrane-protein-complex-subunit-6-emc6-is-a-novel-tumor-suppressor-in-gastric-cancer
#20
Xiaokun Wang, Yan Xia, Chentong Xu, Xin Lin, Peng Xue, Shijie Zhu, Yun Bai, Yingyu Chen
Endoplasmic reticulum (ER) membrane protein complex subunit 6 (EMC6) is a novel human autophagy-related molecule. Here, using tissue microarray and immunohistochemistry, we report that EMC6 protein is lost or reduced in glandular cells of patients with gastric adenocarcinoma, compared to normal stomach mucosa. Overexpression of EMC6 in gastric cancer cells inhibited cell growth, migration, and invasion, and induced apoptosis and cell cycle arrest at S-phase. Further investigation suggested that EMC6 overexpression in BGC823 cells reduced tumorigenicity in a xenograft model, demonstrating that EMC6 has the characteristics of a tumor suppressor...
June 26, 2017: BMB Reports
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