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https://www.readbyqxmd.com/read/29785111/association-of-serotonin-receptor-2a-haplotypes-with-obsessive-compulsive-disorder-and-its-treatment-response-in-iranian-patients-a-genetic-and-pharmacogenetic-study
#1
Marzie Sina, Abolhassan Ahmadiani, Sareh Asadi, Jamal Shams
Introduction: Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder causing intrusive thoughts or repetitive behaviors. Serotonin reuptake inhibitors are used for OCD treatment, but 40%-60% of patients do not respond to them adequately. In this study, the associations of serotonin receptor 2a polymorphisms rs6311 and rs6313 with OCD, its familial form and fluvoxamine treatment response in Iranian population were investigated. Patients and methods: Association analyses were conducted in 293 OCD cases fulfilling the Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV-TR and 245 controls...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29780877/disgust-and-the-rubber-hand-illusion-a-registered-replication-report-of-jalal-krishnakumar-and-ramachandran-2015
#2
Hiroshi Nitta, Haruto Tomita, Yi Zhang, Xinxin Zhou, Yuki Yamada
Heightened experience of disgust is a feature of obsessive-compulsive disorder (OCD), particularly contamination-related OCD (C-OCD). Previous studies of the rubber hand illusion (RHI) reported that the sense of body ownership is related to the interaction between vision, touch, and proprioception. One recent study demonstrated a link between the RHI and disgust, suggesting that there is an interaction between these three perceptual modalities and disgust (Jalal et al., PLOS ONE 10:e0139159, 2015). However, there have been no direct replications of this initial study...
2018: Cognitive Research: Principles and Implications
https://www.readbyqxmd.com/read/29778276/dissociable-frontostriatal-connectivity-mechanism-and-predictor-of-the-clinical-efficacy-of-capsulotomy-in-obsessive-compulsive-disorder
#3
Dazhi Yin, ChenCheng Zhang, Qiming Lv, Xiaoyu Chen, Kristina Zeljic, Hengfen Gong, Shikun Zhan, Haiyan Jin, Zheng Wang, Bomin Sun
BACKGROUND: Little is known about the neural mechanism and response variability underlying neurosurgical interventions for intractable obsessive-compulsive disorder (OCD). METHODS: Of 81 OCD patients screened for capsulotomy identified in our institutional database, 36 patients with clinical assessment before and after capsulotomy and imaging data (9 of 36 patients without postoperative imaging data used as an independent test group), and 29 healthy control subjects were retrospectively recruited...
April 22, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29774005/the-bergen-4-day-ocd-treatment-delivered-in-a-group-setting-12-month-follow-up
#4
Bjarne Hansen, Kristen Hagen, Lars-Göran Öst, Stian Solem, Gerd Kvale
The Bergen 4-day concentrated exposure treatment (cET) for obsessive-compulsive disorder (OCD) has proven highly acceptable; with practically no drop-out and a 6 month remission rate of nearly 70%. The aim of the present study was to evaluate long term gains of the approach, and to compare the results to findings from our recent meta-analysis. Sixty-nine of 95 patients consecutively referred to an outpatient clinic in the specialist health care, were offered the Bergen 4-day treatment. Among the 65 who initiated treatment, 60...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29761016/the-effects-of-cognitive-behavioral-therapy-on-resting-state-functional-brain-network-in-drug-naive-patients-with-obsessive-compulsive-disorder
#5
Ping Li, Xiangyun Yang, Andrew J Greenshaw, Sufang Li, Jia Luo, Haiying Han, Jing Liu, Zhaoxi Zhong, Zhihua Guo, Hongfang Xiong, Shumin Yao, Yunhui Chen, Jing Sun, Zhanjiang Li
Objectives: Although cognitive behavioral therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD), the treatment mechanisms remain poorly understood. This study aimed to investigate the effects of CBT on changes in the intrinsic whole-brain functional network of OCD patients. Materials and Methods: Twenty drug-naive and noncomorbid OCD patients were recruited, and resting-state functional magnetic resonance imaging was performed before and after 12 weeks of CBT...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29760673/three-week-inpatient-treatment-of-obsessive-compulsive-disorder-a-6-month-follow-up-study
#6
Torun Grøtte, Bjarne Hansen, Svein Haseth, Patrick A Vogel, Ismail C Guzey, Stian Solem
Background: Specialized inpatient or residential treatment might be an alternative treatment approach for patients with obsessive-compulsive disorder (OCD) that do not respond satisfactorily to the standard outpatient treatment formats. Method: The aim of this open trial was to investigate the 6-month effectiveness of a 3-week inpatient treatment of OCD, where exposure with response prevention (ERP) was the main treatment intervention. The sample consisted of 187 adult patients with OCD, all with previous treatment attempts for OCD...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29755715/a-deep-belief-network-and-dempster-shafer-based-multiclassifier-for-the-pathology-stage-of-prostate-cancer
#7
Jae Kwon Kim, Mun Joo Choi, Jong Sik Lee, Jun Hyuk Hong, Choung-Soo Kim, Seong Il Seo, Chang Wook Jeong, Seok-Soo Byun, Kyo Chul Koo, Byung Ha Chung, Yong Hyun Park, Ji Youl Lee, In Young Choi
Object: Pathologic prediction of prostate cancer can be made by predicting the patient's prostate metastasis prior to surgery based on biopsy information. Because biopsy variables associated with pathology have uncertainty regarding individual patient differences, a method for classification according to these variables is needed. Method: We propose a deep belief network and Dempster-Shafer- (DBN-DS-) based multiclassifier for the pathologic prediction of prostate cancer...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29754712/to-what-extent-do-clinical-practice-guidelines-respond-to-the-needs-and-preferences-of-patients-diagnosed-with-obsessive-compulsive-disorder
#8
Amelia Villena-Jimena, Clara Gómez-Ocaña, Gisela Amor-Mercado, Amanda Núñez-Vega, José Miguel Morales-Asencio, María Magdalena Hurtado
INTRODUCTION: The number of Clinical Practice Guidelines (CPG) to help in making clinical decisions is increasing. However, there is currently a lack of CPG for Obsessive-Compulsive Disorder that take into account the requirements and expectations of the patients. OBJECTIVE: The aim of the present study was to determine whether recommendations of the NICE guideline, "Obsessive-compulsive disorder: core interventions in the treatment of obsessive-compulsive disorder and body dysmorphic disorder" agrees with the needs and preferences of patients diagnosed with OCD in the mental health service...
April 2018: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/29743581/evolution-of-gamma-knife-capsulotomy-for-intractable-obsessive-compulsive-disorder
#9
REVIEW
Euripedes C Miguel, Antonio C Lopes, Nicole C R McLaughlin, Georg Norén, André F Gentil, Clement Hamani, Roseli G Shavitt, Marcelo C Batistuzzo, Edoardo F Q Vattimo, Miguel Canteras, Antonio De Salles, Alessandra Gorgulho, João Victor Salvajoli, Erich Talamoni Fonoff, Ian Paddick, Marcelo Q Hoexter, Christer Lindquist, Suzanne N Haber, Benjamin D Greenberg, Sameer A Sheth
For more than half a century, stereotactic neurosurgical procedures have been available to treat patients with severe, debilitating symptoms of obsessive-compulsive disorder (OCD) that have proven refractory to extensive, appropriate pharmacological, and psychological treatment. Although reliable predictors of outcome remain elusive, the establishment of narrower selection criteria for neurosurgical candidacy, together with a better understanding of the functional neuroanatomy implicated in OCD, has resulted in improved clinical efficacy for an array of ablative and non-ablative intervention techniques targeting the cingulum, internal capsule, and other limbic regions...
May 9, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29739634/mindfulness-based-exposure-and-response-prevention-for-obsessive-compulsive-disorder-findings-from-a-pilot-randomised-controlled-trial
#10
Clara Strauss, Laura Lea, Mark Hayward, Elizabeth Forrester, Tamara Leeuwerik, Anna-Marie Jones, Claire Rosten
BACKGROUND: Only about half of people with obsessive compulsive disorder (OCD) show clinically significant improvement following the recommended therapy, exposure and response prevention (ERP), partly due to poor therapy acceptability. A mindfulness-based approach to ERP (MB-ERP) has the potential to improve acceptability and outcomes. METHODS: This was an internal pilot randomised controlled trial (RCT) of group MB-ERP compared to group ERP. 37 participants meeting DSM-IV OCD criteria were randomly allocated to MB-ERP or ERP...
April 30, 2018: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29736570/surgical-treatment-paradigms-of-ankle-lateral-instability-osteochondral-defects-and-impingement
#11
Hélder Pereira, Gwendolyn Vuurberg, Pietro Spennacchio, Jorge Batista, Pieter D'Hooghe, Kenneth Hunt, Niek Van Dijk
Ankle sprain is amongst the most frequent musculoskeletal injuries, particularly during sports activities. Chronic ankle instability (CAI) resulting from an ankle sprain might have severe long-lasting consequences on the ankle joint. Despite the fact that most patients will respond favourably to appropriate conservative treatment, around 20% will develop symptomatic CAI with sense of giving away and recurrent sprains leading to functional impairment. "Classical" surgical repair by Brostrom-like surgery in one of its many modifications has achieved good results over the years...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29728248/determining-anxiety-in-obsessive-compulsive-disorder-through-behavioural-clustering-and-variations-in-repetition-intensity
#12
Conor Cameron, Ibrahim Khalil, David Castle
BACKGROUND AND OBJECTIVES: Over the last decade, the application of computer vision techniques to the analysis of behavioural patterns has seen a considerable increase in research interest. One such interesting and recent application is the visual behavioural analysis of mental disorders. Despite the very recent surge in interest in this area, relatively little has been done thus far to assist individuals living with Obsessive Compulsive Disorder. The work proposed herein represents a proof of concept system designed to demonstrate the efficacy of such an approach, from the computational perspective...
July 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29723733/positive-clinical-effects-of-gamma-knife-capsulotomy-in-a-patient-with-deep-brain-stimulation-refractory-tourette-syndrome-and-obsessive-compulsive-disorder
#13
Raphaëlle Richieri, Graham Blackman, Richard Musil, Giorgio Spatola, Andrea E Cavanna, Christophe Lançon, Jean Régis
We report the first case of a patient with severe, intractable Tourette Syndrome with comorbid Obsessive Compulsive disorder, who recovered from both disorders with gamma-knife (GK) stereotactic radiosurgery following deep brain stimulation (DBS). This case highlights the possible role of the internal capsule within the neural circuitries underlying both TS and OCD, and suggests that in cases of treatment-refractory TS and comorbid OCD, bilateral anterior capsulotomy using stereotactic radiosurgery may be a viable treatment option...
April 26, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29722936/antibiotics-for-pandas-limited-evidence-review-and-putative-mechanisms-of-action
#14
Elisabetta Burchi, Stefano Pallanti
Objective: Antibiotics have been used extensively by clinicians to treat patients with PANDAS or PANS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and pediatric acute-onset neuropsychiatric syndrome, respectively). This review examines the best-quality evidence supporting the practice-based use of antibiotics in these psychiatric conditions. Data Sources: PubMed was searched for English-language articles published between January 1994 and July 2017 using the search terms [PANDAS OR PANS OR new-onset pediatric OCD] AND [antibiotics OR macrolides OR beta-lactams]...
May 3, 2018: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29717977/a-study-of-novel-bilateral-thermal-capsulotomy-with-focused-ultrasound-for-treatment-refractory-obsessive-compulsive-disorder-2-year-follow-up
#15
Se Joo Kim, Daeyoung Roh, Hyun Ho Jung, Won Seok Chang, Chan-Hyung Kim, Jin Woo Chang
BACKGROUND: Recently, a new thermal lesioning approach using magnetic-resonance-guided focused ultrasound (MRgFUS) was introduced for the treatment of neurologic disorders. However, only 2 studies have used this approach for treatment-refractory obsessive-compulsive disorder (OCD), and follow-up was short-term. We investigated the efficacy and safety of bilateral thermal lesioning of the anterior limb of the internal capsule using MRgFUS in patients with treatment-refractory OCD and followed them for 2 years...
May 2, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29713171/does-higher-severity-really-correlate-with-a-worse-quality-of-life-in-obsessive-compulsive-disorder-a-meta-regression
#16
Andrea Pozza, Christine Lochner, Fabio Ferretti, Alessandro Cuomo, Anna Coluccia
Background: Obsessive-compulsive disorder (OCD) is one of the leading causes of disability and reduced quality of life (QOL), with impairment in a number of domains. However, there is a paucity of literature on the association between severity of OCD symptoms and QOL, and the data that do exist are inconsistent. In addition, the role of severity in QOL has not been summarized as yet from a cross-generational perspective (ie, across childhood/adolescence and adulthood). Through meta-regression techniques, the current study summarized evidence about the moderator role of severity of OCD symptoms on differences in global QOL between individuals with OCD and controls...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29704962/new-directions-in-the-cognitive-behavioral-treatment-of-ocd-theory-research-and-practice
#17
Jonathan S Abramowitz, Shannon M Blakey, Lillian Reuman, Jennifer L Buchholz
The beneficial effects of cognitive-behavioral interventions (particularly exposure and response prevention) for OCD are among the most consistent research findings in the mental health literature. Nevertheless, even after an adequate trial, many individuals experience residual symptoms, and others never receive adequate treatment due to limited access. These and other issues have prompted clinicians and researchers to search for ways to improve the conceptual and practical aspects of existing treatment approaches, as well as look for augmentation strategies...
May 2018: Behavior Therapy
https://www.readbyqxmd.com/read/29701156/diagnostic-issues-in-early-onset-obsessive-compulsive-disorder-and-their-treatment-implications
#18
Elisabetta Burchi, Stefano Pallanti
BACKGROUND: The lifespan approach and recent shift in the conceptualization of Obsessive-Compulsive Disorder (OCD) promoted by the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM5) along with novel insights into the pathogenesis of this heterogeneous disorder are driving the development of new outcome measures and new treatments for a disease that, on the other hand, is characterized by high rates of refractoriness. OBJECTIVE AND METHODS: The aim of this review is to provide a discussion of the translational evidence about Early Onset OCD (EO) in compliance with a neurodevelopmental and RdoC perspective...
April 26, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29697710/symptom-severity-and-its-clinical-correlates-in-kleptomania
#19
Jon E Grant, Samuel R Chamberlain
BACKGROUND: Kleptomania (compulsive stealing) remains poorly understood, with limited data regarding its underlying pathophysiology and appropriate treatment choices. METHODS: Participants (N = 112) age 18 to 65 with a primary, current diagnosis of kleptomania were assessed for the severity of their stealing behavior and urges to steal, as well as related mental health symptoms. To identify clinical and demographic measures associated with variation in disease severity, we utilized the statistical technique of partial least squares...
May 2018: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/29696644/validating-an-abbreviated-version-of-the-obsessive-beliefs-questionnaire
#20
Jean-Philippe Gagné, Nathaniel Van Kirk, Alexandra Hernandez-Vallant, Sriramya Potluri, Jason W Krompinger, Jordan E Cattie, Lauryn E Garner, Jesse M Crosby, Brian P Brennan, Jason A Elias
OBJECTIVES: A shorter version of the Obsessive Beliefs Questionnaire (OBQ-44) is needed to promote the use of this measure in research and increase our understanding of cognitive phenomena maintaining obsessive-compulsive disorder (OCD). Additionally, an abbreviated version of the OBQ-44 would encourage frequent monitoring of dysfunctional beliefs in intensive care settings. This study aimed to validate a nine-item version of the questionnaire (OBQ-9). METHOD: Participants seeking intensive/residential treatment for OCD (N = 311) completed relevant measures on a weekly basis and at admission and discharge...
April 26, 2018: Journal of Clinical Psychology
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