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https://www.readbyqxmd.com/read/29349890/case-report-cytochrome-p450-implications-for-comorbid-adhd-and-ocd-pharmacotherapy
#1
Michaela K Hogan, Nikhil P Rao
TOPIC: This case report details the treatment of an early adolescent already receiving treatment for attention-deficit hyperactivity disorder who presents with recurrent obsessive-compulsive disorder. Potential atomoxetine (Strattera) and fluoxetine (Prozac) interactions via Cytochrome P450 (CYP450) pathways are examined and alternate therapies are recommended. PURPOSE: Provide a discussion of psychopharmacogenomics, especially in the case of combining medications, CYP450 enzymes, and clinical implications in the context of the burgeoning field of precision medicine...
January 19, 2018: Journal of Child and Adolescent Psychiatric Nursing
https://www.readbyqxmd.com/read/29349503/is-there-any-difference-between-open-and-arthroscopic-treatment-for-osteochondritis-dissecans-ocd-of-the-humeral-capitellum-a-systematic-review-and-meta-analysis
#2
Yi Lu, Yi Jun Li, Si Yi Guo, Hai Long Zhang
PURPOSE: We present a systematic review of the recent literatures regarding the arthroscopic and open technique in fragment fixation for osteochondritis dissecans (OCD) of the humeral capitellum and an analysis of the subjective and objective outcomes between these two procedures. METHODS: PubMed and EMBASE were reviewed for suitable articles relating to fragment fixation for OCD, both open and arthroscopic. We included all studies reporting on the clinical outcomes of these two procedures that were published in the English language...
January 18, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29343875/-trazodone-prolonged-release-in-bipolar-disorder-ii-obsessive-compulsive-disorder-comorbidity-a-case-report
#3
Liliana Lorettu, Giampiero Meli, Elena Antonioli, Antonio Zeppa, Paolo Milia, Alessandra Nivoli
Approximately 21% of patients with bipolar disorder (BD) also have an additional diagnosis of obsessive-compulsive disorder (OCD). This condition is associated with a more severe prognosis and complicates the treatment of BD. In our case report we provide documentary evidence of our experience with trazodone prolonged release in the treatment of depressive phase in a patient with BD II-OCD comorbidity. Rationality in the choise of treatment was based on the need to manage depressive and obsessive symptoms without facilitating hypomania switches...
November 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29330217/a-systematic-review-of-network-meta-analyses-for-pharmacological-treatment-of-common-mental-disorders
#4
REVIEW
Taryn Williams, Dan J Stein, Jonathan Ipser
QUESTION: Network meta-analyses (NMAs) of treatment efficacy across different pharmacological treatments help inform clinical decision-making, but their methodological quality may vary a lot depending also on the quality of the included primary studies. We therefore conducted a systematic review of NMAs of pharmacological treatment for common mental disorders in order to assess the methodological quality of these NMAs, and to relate study characteristics to the rankings of efficacy and tolerability...
January 12, 2018: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29324911/psychological-consideration-in-patients-with-cerebral-gliomas-candidates-for-intra-operative-radiation-therapy-based-on-tumor-location
#5
Tohid Emami Meybodi, Masoumeh Najafi, Ali Keipourfard, Amir Nikouei, Afsoun Seddighi
OBJECTIVE: Intra-operative Radiation Therapy (IORT) is gaining popularity as an adjuvant option to surgical resection, in treatment of glioblastoma multiforme (GBM) for increasing survival rate, which a highly aggressive cerebral tumor with poor prognosis. Τhe authors plan to investigate the effects of IORT combined with surgical resection on the psychological status of these patients based on tumor location. SUBJECT AND METHODS: From December 2013 to February 2017, we have enrolled 109 patients with high grade cerebral gliomas, documented by Magnetic Resonance Spectroscopy (MRS)...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29310732/chronic-obsessive-compulsive-disorder-prognostic-factors
#6
Lucas J B van Oudheusden, Merijn Eikelenboom, Harold J G M van Megen, Henny A D Visser, Koen Schruers, Gert-Jan Hendriks, Nic van der Wee, Adriaan W Hoogendoorn, Patricia van Oppen, Anton J L M van Balkom
BACKGROUND: The course of illness in obsessive-compulsive disorder (OCD) varies significantly between patients. Little is known about factors predicting a chronic course of illness. The aim of this study is to identify factors involved in inducing and in maintaining chronicity in OCD. METHODS: The present study is embedded within the Netherlands Obsessive Compulsive Disorder Association (NOCDA) study, an ongoing multicenter naturalistic cohort study designed to identify predictors of long-term course and outcome in OCD...
January 9, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29306047/unified-protocol-for-the-discontinuation-of-long-term-serotonin-reuptake-inhibitors-in-obsessive-compulsive-disorder-study-protocol-and-methods
#7
Christina L Boisseau, Steven A Rasmussen
Obsessive-compulsive disorder (OCD) is chronic psychiatric disorder associated with high rates of functional impairment and decreased quality of life. Although serotonin reuptake inhibitors have demonstrated efficacy in the treatment of OCD, little data is available to guide clinicians on how to manage these medications long-term. Cognitive-behavioral approaches provide a promising avenue for helping OCD patients discontinue maintenance SRIs while minimizing the potential for symptom worsening. This manuscript describes the rationale and methods for pilot feasibility study designed to a unified, cognitive-behavioral strategy for discontinuing long-term SRIs in OCD...
January 3, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29305286/clinical-outcomes-of-osteochondral-allograft-transplantation-for-secondary-treatment-of-osteochondritis-dissecans-of-the-knee-in-skeletally-mature-patients
#8
Eric J Cotter, Rachel M Frank, Kevin C Wang, Trifon Totlis, Sarah Poland, Maximillian A Meyer, Brian J Cole
PURPOSE: To report clinical outcomes of osteochondral allograft transplantation (OCA) for skeletally mature patients with osteochondritis dissecans (OCD) lesions of the knee in whom prior surgical intervention has failed, and to describe return-to-sport (RTS) rates and any predictive demographic or preoperative variables associated with a higher likelihood to RTS. METHODS: Patients who underwent OCA by a single surgeon (B.J.C.) between October 1, 2002, and November 30, 2014, for a diagnosis of OCD with a minimum of 2 years' follow-up were included...
January 2, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29299728/psychopharmacology-utilization-among-children-with-anxiety-and-obsessive-compulsive-and-related-disorders-following-hurricane-katrina
#9
Eric A Storch, Sean Gregory, Alison Salloum, Troy Quast
This study aimed to examine the impact of Hurricane Katrina exposure on medication utilization among children with pre-existing anxiety and obsessive-compulsive and related disorders (OCRDs). Medicaid claims data from 2004 to 2006 were analyzed. Children with pre-existing anxiety/OCRDs were compared as a function of those living in a Louisiana disaster area, Louisiana non-disaster area, or Texas in terms of filled prescriptions and average days medication supply. This was further examined as a function of disorder/medication type...
January 3, 2018: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/29291473/the-effects-of-the-non-contingent-presentation-of-safety-signals-on-the-elimination-of-safety-behaviors-an-experimental-comparison-between-individuals-with-low-and-high-obsessive-compulsive-profiles
#10
Ioannis Angelakis, Jennifer L Austin
BACKGROUND AND OBJECTIVES: Safety behaviors, defined as engagement in avoidance within safe environments, are a key symptom of obsessive-compulsive and related disorders. They may interfere with daily functioning and as such their emission should be reduced. The purpose of the current study is to investigate the effects of the non-contingent presentation of safety signals (cues produced by safety behaviors) on reducing safety behaviors in participants self-reporting low and high OCD profiles...
December 27, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/29287236/moderators-and-predictors-of-response-to-cognitive-behaviour-therapy-for-pediatric-obsessive-compulsive-disorder-a-systematic-review
#11
Cynthia Turner, Beth O'Gorman, Archana Nair, Richard O'Kearney
We report a systematic review of moderators of CBT efficacy for pediatric OCD relative to other treatments. CENTRAL, MEDLINE, EMBASE, CINAHL, and PsycINFO were searched for RCTs reporting on effect moderation for CBT outcomes. Five studies (N = 365) examined 17 variables with three significant moderators identified. Compared to pill-placebo, CBT monotherapy was not effective for children with a family history of OCD but was for those without a family history. For children with a family history, CBT plus sertraline efficacy was attenuated but remained significant...
December 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29285414/deep-brain-stimulation-for-obsessive-compulsive-disorder-knowledge-and-concerns-among-psychiatrists-psychotherapists-and-patients
#12
Matilda Naesström, Patric Blomstedt, Marwan Hariz, Owe Bodlund
Background: Deep brain stimulation (DBS) is under investigation for severe obsessive-compulsive disorder (OCD) resistant to other therapies. The number of implants worldwide is slowly increasing. Therefore, it is of importance to explore knowledge and concerns of this novel treatment among patients and their psychiatric healthcare contacts. This information is relevant for scientific professionals working with clinical studies for DBS for this indication. Especially, for future study designs and the creation of information targeting healthcare professionals and patients...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29284808/functional-impairment-and-quality-of-life-in-patients-with-obsessive-compulsive-disorder
#13
Puspita Sahoo, Rati Ranjan Sethy, Daya Ram
Background: This study was carried out to enumerate the level of difference in functional impairment and quality of life (QOL) in obsessive-compulsive disorder (OCD) patients and normal control group to find out the relationship among ICD functional impairment and QOL. Methodology: Thirty patients diagnosed with OCD as per International Classification of Diseases Diagnostic Criteria for Research-10 were taken for study. The control group consists of 30 normal participants from the community...
November 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29284508/inflammatory-dysregulation-of-monocytes-in-pediatric-patients-with-obsessive-compulsive-disorder
#14
Natalia Rodríguez, Astrid Morer, E Azucena González-Navarro, Carles Serra-Pages, Daniel Boloc, Teresa Torres, Susana García-Cerro, Sergi Mas, Patricia Gassó, Luisa Lázaro
BACKGROUND: Although the exact etiology of obsessive-compulsive disorder (OCD) is unknown, there is growing evidence of a role for immune dysregulation in the pathophysiology of the disease, especially in the innate immune system including the microglia. To test this hypothesis, we studied inflammatory markers in monocytes from pediatric patients with OCD and from healthy controls. METHODS: We determined the percentages of total monocytes, CD16+ monocytes, and classical (CD14highCD16-), intermediate (CD14highCD16low), and non-classical (CD14lowCD16high) monocyte subsets in 102 patients with early-onset OCD and in 47 healthy controls...
December 28, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29278206/a-systematic-review-of-evidence-based-treatment-strategies-for-obsessive-compulsive-disorder-resistant-to-first-line-pharmacotherapy
#15
Umberto Albert, Donatella Marazziti, Gabriele Di Salvo, Francesca Solia, Gianluca Rosso, Giuseppe Maina
BACKGROUND: Serotonin reuptake inhibitors (SRIs) and cognitive-behavioral psychotherapy (CBT) are first-line treatments for obsessive-compulsive disorder (OCD). However, a significant proportion of patients do not respond satisfactorily to first-choice treatments. Several options have been investigated for the management of resistant patients. OBJECTIVE: The aim of the present paper is to systematically review the available literature concerning the strategies for the treatment of resistant adult patients with OCD...
December 22, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29276465/a-case-report-of-osteochondritis-dissecans-in-a-rare-location-the-lateral-femoral-trochlea
#16
Federico Villafañe, Nathaniel Holloway, Norman Kettner
Objective: The purpose of this case report is to describe a rare location for knee osteochondritis dissecans (OCD). Clinical Features: A 28-year-old man presented to a chiropractic clinic with left posterolateral knee pain and swelling with joint locking after falling asleep with knees bent. A history of knee locking was reported by the patient. At presentation, he demonstrated the inability to straighten his left knee. On a pain scale of 1 to 10, he experienced level-8 stabbing pain during all knee ranges of motion with radiation to the foot...
December 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29276354/multidimensional-approaches-for-a-case-of-severe-adult-obsessive-compulsive-disorder
#17
Zhongyong Shi, Xinchun Mei, Yingbo Zhu, Yu Shuai, Yupeng Chen, Yujie Wu, Yuan Shen
Obsessive-compulsive disorder (OCD) is a chronic, distressing and substantially impairing neuropsychiatric disorder, characterized by obsessions or compulsions. The current case describes a 44-year-old adult female diagnosed with OCD. The patient had an incomplete response to several SSRIs alone during her past treatment, and led a poor-quality life for at least three years. Current multidimensional approaches, including combined cognitive behavioral therapy (CBT) and the Selective Serotonin Reuptake Inhibitor (SSRI, Sertraline) with a small dose of antipsychotics (Aripiprazole) for augmentation, as well as familial support and resources from the internet were provided for the patient for six months...
October 25, 2017: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29276039/diagnosis-and-treatment-of-osteochondritis-dissecans-of-the-humeral-capitellum
#18
Masahiro Maruyama, Masatoshi Takahara, Hiroshi Satake
Osteochondritis dissecans (OCD) of the humeral capitellum is a critical elbow injury in adolescent overhead throwing athletes. However, its etiology remains unknown. Medical examinations using ultrasonography found that the prevalence of capitellar OCD among adolescent baseball players was approximately from 1% to 3%. A plain anteroposterior radiograph with the elbow in 45° of flexion is essential for the diagnosis of an OCD lesion. The stability of OCD lesions is evaluated on plain radiographs, computed tomography, and magnetic resonance imaging (MRI)...
December 21, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29274445/acute-effects-of-electrical-stimulation-of-the-bed-nucleus-of-the-stria-terminalis-internal-capsule-in-obsessive-compulsive-disorder
#19
Lotta Winter, Ivo Heitland, Assel Saryyeva, Götz Lütjens, Kerstin Schwabe, Hans E Heissler, Mesbah Alam, Kai G Kahl, Joachim K Krauss
BACKGROUND: Deep brain stimulation (DBS) has been introduced as a treatment option for treatment-resistant obsessive-compulsive disorder (OCD). However, the optimal stimulation target and the corresponding simulation settings remain unclear. Furthermore, there is limited knowledge about the acute effects of DBS. METHODS: In three patients with treatment-resistant OCD, DBS electrodes were implanted in the bed nucleus of the stria terminalis/internal capsule (BNST/IC)...
December 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29274375/meta-analysis-risk-of-dry-mouth-with-second-generation-antidepressants
#20
Kiley Cappetta, Chad Beyer, Jessica A Johnson, Michael H Bloch
OBJECTIVE: The goal of this meta-analysis was to quantify the risk of dry mouth associated with commonly prescribed antidepressant agents and examine the potential implications of medication class, dose, and pharmacodynamics and dose on risk of treatment-induced dry mouth. DATA SOURCES AND STUDY SELECTION: A PubMed search was conducted to identify double-blind, randomized, placebo-controlled trials examining the efficacy and tolerability of second generation antidepressant medications for adults with depressive disorders, anxiety disorders, and OCD...
December 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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