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https://www.readbyqxmd.com/read/28442404/meta-analytic-investigations-of-common-and-distinct-grey-matter-alterations-in-youths-and-adults-with-obsessive-compulsive-disorder
#1
REVIEW
Xinyu Hu, Mingying Du, Lizhou Chen, Lei Li, Ming Zhou, Lianqing Zhang, Qi Liu, Lu Lu, Kunal Mreedha, Xiaoqi Huang, Qiyong Gong
Obsessive-compulsive disorder (OCD) is a disabling illness with onset generally in childhood. OCD-youths differ from OCD-adults with regard to gender distribution, comorbidity patterns and treatment options. However, little is known about the neural correlate differences underpin those two populations. The current meta-analysis summarizes voxel based morphometry findings to elucidate whether differences of neural correlates exist between these two populations. Both OCD-youths and OCD-adults demonstrated greater striatal volume and smaller prefrontal grey matter volume (GMV)...
April 22, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28433854/comorbidity-age-of-onset-and-suicidality-in-obsessive-compulsive-disorder-ocd-an-international-collaboration
#2
V Brakoulias, V Starcevic, A Belloch, C Brown, Y A Ferrao, L F Fontenelle, C Lochner, D Marazziti, H Matsunaga, E C Miguel, Ycj Reddy, M C do Rosario, R G Shavitt, A Shyam Sundar, D J Stein, A R Torres, K Viswasam
OBJECTIVES: To collate data from multiple obsessive-compulsive disorder (OCD) treatment centers across seven countries and five continents, and to report findings in relation to OCD comorbidity, age of onset of OCD and comorbid disorders, and suicidality, in a large clinical and ethnically diverse sample, with the aim of investigating cultural variation and the utility of the psychiatric diagnostic classification of obsessive-compulsive and related disorders. METHODS: Researchers in the field of OCD were invited to contribute summary statistics on current and lifetime psychiatric comorbidity, age of onset of OCD and comorbid disorders and suicidality in their patients with OCD...
April 12, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28432894/the-structure-correlates-and-treatment-related-changes-of-mindfulness-facets-across-the-anxiety-disorders-and-obsessive-compulsive-disorder
#3
Lance L Hawley, Jenny Rogojanski, Valerie Vorstenbosch, Lena C Quilty, Judith M Laposa, Neil A Rector
Research with non-clinical and clinical samples has examined how mindfulness concepts relate to psychological symptom presentations. However, there is less clarity when examining treatment-seeking patients who experience DSM-diagnosed anxiety and obsessional disorders - both cross-sectionally, and following empirically-supported treatments. The Five Facet Mindfulness Questionnaire (FFMQ; Baer, Smith, Hopkins, Krietemeyer, & Toney, 2006) conceptualizes mindfulness as consisting of five facets: Observing, Describing, Acting with Awareness, Nonreactivity, and Nonjudging...
March 14, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28431305/cognitive-behavioral-high-parental-involvement-treatments-for-pediatric-obsessive-compulsive-disorder-a-meta-analysis
#4
REVIEW
Marina Iniesta-Sepúlveda, Ana I Rosa-Alcázar, Julio Sánchez-Meca, José L Parada-Navas, Ángel Rosa-Alcázar
A meta-analysis on the efficacy of cognitive-behavior-family treatment (CBFT) on children and adolescents with obsessive-compulsive disorder (OCD) was accomplished. The purposes of the study were: (a) to estimate the effect magnitude of CBFT in ameliorating obsessive-compulsive symptoms and reducing family accommodation on pediatric OCD and (b) to identify potential moderator variables of the effect sizes. A literature search enabled us to identify 27 studies that fulfilled our selection criteria. The effect size index was the standardized pretest-postest mean change index...
April 4, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28426824/becoming-more-oneself-changes-in-personality-following-dbs-treatment-for-psychiatric-disorders-experiences-of-ocd-patients-and-general-considerations
#5
Sanneke de Haan, Erik Rietveld, Martin Stokhof, Damiaan Denys
Does DBS change a patient's personality? This is one of the central questions in the debate on the ethics of treatment with Deep Brain Stimulation (DBS). At the moment, however, this important debate is hampered by the fact that there is relatively little data available concerning what patients actually experience following DBS treatment. There are a few qualitative studies with patients with Parkinson's disease and Primary Dystonia and some case reports, but there has been no qualitative study yet with patients suffering from psychiatric disorders...
2017: PloS One
https://www.readbyqxmd.com/read/28425736/implicit-approach-and-avoidance-in-patients-with-obsessive-compulsive-disorder
#6
Barbara Cludius, Anne Katrin Külz, Sarah Landmann, Steffen Moritz, Charlotte E Wittekind
Avoidance is regarded as an important feature for the development and maintenance of obsessive-compulsive disorder (OCD) and is usually assessed using explicit measures such as self-report scales. However, some behavioral schemata are unavailable to introspection, making them partially inaccessible by explicit measures. We used an approach-avoidance task (AAT) as an implicit measure to examine behavioral tendencies in patients with OCD, including patients with checking- and contamination-related symptoms (n = 63), compared with a healthy control group (n = 30)...
April 20, 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28419816/high-rate-of-osteoarthritis-after-osteochondritis-dissecans-fragment-excision-compared-with-surgical-restoration-at-a-mean-16-year-follow-up
#7
Thomas L Sanders, Ayoosh Pareek, Mitchel R Obey, Nicholas R Johnson, James L Carey, Michael J Stuart, Aaron J Krych
BACKGROUND: Osteochondritis dissecans (OCD) is a disorder of subchondral bone that causes adverse effects on the overlying cartilage and commonly affects the knee. The incidence of OCD and its long-term effect on the knee joint are controversial. Hypothesis/Purpose: The purpose of this study was to (1) evaluate the rate of osteoarthritis and knee arthroplasty in a population-based cohort of patients with OCD lesions treated operatively and (2) evaluate factors that may predispose patients to knee osteoarthritis and arthroplasty...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28414963/three-dimensional-excitation-and-emission-matrix-fluorescence-3deem-for-quick-and-pseudo-quantitative-determination-of-protein-and-humic-like-substances-in-full-scale-membrane-bioreactor-mbr
#8
Céline Jacquin, Geoffroy Lesage, Jacqueline Traber, Wouter Pronk, Marc Heran
The goal of this study is to help filling the research gaps linked to the on-line application of fluorescence spectroscopy in wastewater treatment and data processing tools suitable for rapid correction and extraction of data contained in three-dimensional fluorescence excitation-emission matrix (3DEEM) for real-time studies. 3DEEM was evaluated for direct quantification of Effluent Organic Matter (EfOM) fractions in full-scale MBR bulk supernatant and permeate samples. Principal Component Analysis (PCA) was used to investigate possible correlations between conventional Lowry and Dubois methods, Liquid Chromatography coupled to Organic Carbon and Organic Nitrogen Detection (LC-OCD-OND) and 3DEEM...
April 5, 2017: Water Research
https://www.readbyqxmd.com/read/28412602/secondary-outcomes-from-the-pediatric-obsessive-compulsive-disorder-treatment-study-ii
#9
Christine A Conelea, Robert R Selles, Kristen G Benito, Michael M Walther, Jason T Machan, Abbe M Garcia, Jeffrey Sapyta, Sarah Morris, Martin Franklin, Jennifer B Freeman
The Pediatric Obsessive-Compulsive Disorder Treatment Study II (POTS II) investigated the benefit of serotonin reuptake inhibitor (SRI) augmentation with cognitive behavioral therapy (CBT). Primary outcomes focused on OCD symptom change and indicated benefit associated with a full course of CBT. Given that the majority of youth with OCD suffer from significant comorbid symptoms and impaired quality of life, the current study examined POTS II data for effects on secondary outcomes. Participants were 124 youth ages 7-17 years with a primary diagnosis of OCD who were partial responders to an adequate SRI trial...
April 7, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28409563/glutamate-in-pediatric-obsessive-compulsive-disorder-and-response-to-cognitive-behavioral-therapy-randomized-clinical-trial
#10
Joseph O'Neill, John Piacentini, Susanna Chang, Ronald Ly, Tsz M Lai, Casey C Armstrong, Lindsey Bergman, Michelle Rozenman, Tara Peris, Allison Vreeland, Ross Mudgway, Jennifer G Levitt, Noriko Salamon, Stefan Posse, Gerhard S Hellemann, Jeffry R Alger, James T McCracken, Erika L Nurmi
Cognitive-behavioral therapy (CBT) is effective for pediatric obsessive-compulsive disorder (OCD), but non-response is common. Brain glutamate (Glu) signaling may contribute to OCD pathophysiology and moderate CBT outcomes. We assessed whether Glu measured with magnetic resonance spectroscopy (MRS) was associated with OCD and/or CBT response. Youths aged 8-17 with DSM-IV OCD and typically-developing controls underwent 3T proton echo-planar spectroscopic imaging (PEPSI) MRS scans of pregenual anterior cingulate cortex (pACC) and ventral posterior cingulate cortex (vPCC)-regions possibly affected by OCD-at baseline...
April 14, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28398084/the-reliability-of-assessing-radiographic-healing-of-osteochondritis-dissecans-of-the-knee
#11
Eric J Wall, Matthew D Milewski, James L Carey, Kevin G Shea, Theodore J Ganley, John D Polousky, Nathan L Grimm, Emily A Eismann, Jake C Jacobs, Lucas Murnaghan, Carl W Nissen, Gregory D Myer, Jennifer Weiss, Eric W Edmonds, Allen F Anderson, Roger M Lyon, Benton E Heyworth, Peter D Fabricant, Andy Zbojniewicz
BACKGROUND: The reliability of assessing healing on plain radiographs has not been well-established for knee osteochondritis dissecans (OCD). PURPOSE: To determine the inter- and intrarater reliability of specific radiographic criteria in judging healing of femoral condyle OCD. STUDY DESIGN: Cohort study (Diagnosis); Level of evidence, 3. METHODS: Ten orthopedic sports surgeons rated the radiographic healing of 30 knee OCD lesions at 2 time points, a minimum of 1 month apart...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28397354/seeking-help-for-obsessive-compulsive-disorder-ocd-a-qualitative-study-of-the-enablers-and-barriers-conducted-by-a-researcher-with-personal-experience-of-ocd
#12
Karen J Robinson, Diana Rose, Paul M Salkovskis
OBJECTIVES: Obsessive compulsive disorder (OCD) can be hugely disabling. Although very effective psychological treatments exist, many people delay years before seeking help or never seek treatment. There have been clinical observation and short questionnaire studies on why people delay, but little qualitative research exists on this complex subject. The present qualitative study aimed to identify the barriers to seeking treatment and the factors that encourage or push people to seek help for their OCD (positive and negative enablers)...
April 10, 2017: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/28390444/the-relationship-between-obsessive-compulsive-personality-and-obsessive-compulsive-disorder-treatment-outcomes-predictive-utility-and-clinically-significant-change
#13
Shalane K Sadri, Peter M McEvoy, Sarah J Egan, Robert T Kane, Clare S Rees, Rebecca A Anderson
BACKGROUND: The evidence regarding whether co-morbid obsessive compulsive personality disorder (OCPD) is associated with treatment outcomes in obsessive compulsive disorder (OCD) is mixed, with some research indicating that OCPD is associated with poorer response, and some showing that it is associated with improved response. AIMS: We sought to explore the role of OCPD diagnosis and the personality domain of conscientiousness on treatment outcomes for exposure and response prevention for OCD...
April 9, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28389841/an-initial-case-series-of-intensive-cognitive-behavioral-therapy-for-obsessive-compulsive-disorder-in-adolescents-with-autism-spectrum-disorder
#14
Marina Iniesta-Sepúlveda, Joshua M Nadeau, Amaya Ramos, Brian Kay, Bradley C Riemann, Eric A Storch
Obsessive-compulsive disorder (OCD) is prevalent among youth with autism spectrum disorder (ASD). Cognitive-behavioral therapy (CBT) with ASD-specific modifications has support for treating OCD in this population; however, use of intensive CBT in youth with ASD and severe OCD has not been tested. The current study examined the preliminary effectiveness of an individualized intensive CBT protocol for OCD in adolescents with ASD. Nine adolescents (aged 11-17 years) completed a regimen of intensive CBT (range 24-80 daily sessions) incorporating exposure with response prevention (ERP)...
April 7, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28388457/sleep-disturbances-in-obsessive-compulsive-disorder-association-with-non-response-to-repetitive-transcranial-magnetic-stimulation-rtms
#15
Lana Donse, Alexander T Sack, Paul B Fitzgerald, Martijn Arns
Background Repetitive transcranial magnetic stimulation (rTMS) is a promising augmentation strategy for treatment-refractory OCD. However, a substantial group still fails to respond. Sleep disorders, e.g. circadian rhythm sleep disorders (CRSD), are highly prevalent in OCD and might mediate treatment response. The aims of the current study were to compare sleep disturbances between OCD patients and healthy subjects as well as between rTMS responders and non-responders, and most importantly to determine sleep-related predictors of rTMS non-response...
March 31, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28386221/deep-brain-stimulation-of-the-nucleus-accumbens-core-affects-trait-impulsivity-in-a-baseline-dependent-manner
#16
Maria C Schippers, Bastiaan Bruinsma, Mathijs Gaastra, Tanja I Mesman, Damiaan Denys, Taco J De Vries, Tommy Pattij
Deep brain stimulation (DBS) of the nucleus accumbens (NA) is explored as a treatment for refractory psychiatric disorders, such as obsessive-compulsive disorder (OCD), depressive disorder (MDD), and substance use disorder (SUD). A common feature of some of these disorders is pathological impulsivity. Here, the effects of NAcore DBS on impulsive choice and impulsive action, two distinct forms of impulsive behavior, were investigated in translational animal tasks, the delayed reward task (DRT) and five-choice serial reaction time task (5-CSRTT), respectively...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28384832/obsessive-compulsive-disorder-advances-in-diagnosis-and-treatment
#17
Matthew E Hirschtritt, Michael H Bloch, Carol A Mathews
Importance: Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder associated with significant impairment and a lifetime prevalence of 1% to 3%; however, it is often missed in primary care settings and frequently undertreated. Objective: To review the most current data regarding screening, diagnosis, and treatment options for OCD. Evidence Review: We searched PubMed, EMBASE, and PsycINFO to identify randomized controlled trials (RCTs), meta-analyses, and systematic reviews that addressed screening and diagnostic and treatment approaches for OCD among adults (≥18 years), published between January 1, 2011, and September 30, 2016...
April 4, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28379724/parsing-the-phenotype-of-obsessive-compulsive-tic-disorder-octd-a-multidisciplinary-consensus
#18
Bernardo Dell'Osso, Donatella Marazziti, Umberto Albert, Stefano Pallanti, Orsola Gambini, Antonio Tundo, Carlotta Zanaboni, Domenico Servello, Renata Rizzo, Luciana Scalone, Beatrice Benatti, A Carlo Altamura, Mauro Porta
Obsessive-Compulsive Disorder (OCD) and Tic Disorder (TD) are highly disabling and often comorbid conditions. Of note, the DSM-5 acknowledged a new 'tic-related' specifier for OCD, which might be referred to as Obsessive-Compulsive Tic Disorder (OCTD), raising new interest toward a better clinical characterisation of affected patients. Available literature indicates that early onset, male gender, sensory phenomena and obsessions of symmetry, aggressiveness, hoarding, exactness and sounds as well as comorbidity with Attention Deficit Hyperactivity Disorder (ADHD) may be of more frequent observation in patients with OCTD...
February 24, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28375695/outpatient-treatment-patterns-of-pediatric-obsessive-compulsive-disorder
#19
Joseph L Smith, Nicole M McBride, Eric A Storch
INTRODUCTION: Little is known about community physician treatment practices for children with obsessive-compulsive disorder (OCD). This study is the first to describe the treatment of pediatric OCD in office-based and outpatient department-based physicians in the United States. METHODS: Data from the 2003-2011 National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey were used. We provided descriptive statistics for sample characteristics and treatments administered during the visit, and examined differences in treatment by comorbid conditions and settings using logistic regression...
April 4, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28375077/ocd-obsessive-compulsive-%C3%A2-disgust-the-role-of-disgust-in-obsessive-compulsive-disorder
#20
Tracy Bhikram, Elia Abi-Jaoude, Paul Sandor
Recent research has identified the important role of disgust in the symptomatology of obsessive-compulsive disorder (OCD). Exaggerated and inappropriate disgust reactions may drive some of the symptoms of OCD, and in some cases, may even eclipse feelings of anxiety. This paper reviews behavioural and neuroimaging research that recognizes the prominent role of disgust in contributing to OCD symptoms, especially contamination-based symptoms. We discuss how elevated behavioural and biological markers of disgust reported in OCD populations support the need for alternative clinical treatment strategies and theoretical models of OCD...
April 4, 2017: Journal of Psychiatry & Neuroscience: JPN
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