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https://www.readbyqxmd.com/read/28214854/microrna-183-suppresses-neuropathic-pain-and-expression-of-ampa-receptors-by-targeting-mtor-vegf-signaling-pathway
#1
Xiaojuan Xie, Ligang Ma, Kai Xi, Wei Zhang, Dongmei Fan
BACKGROUND: Neuropathic pain is a type of chronic pain that results from dysfunctions of the somatosensory nerve system. This study was aimed to investigate the effect of mTOR/VEGF signaling pathway on neuropathic pain and the regulation mechanisms of miR-183 on AMPA Receptors through mTOR/VEGF signaling pathway. METHODS: Chronic compress injury (CCI) model was constructed in the current study, we used paw withdrawal mechanic threshold (PWMT) and paw withdrawal thermal latency (PWTL) to observe mTOR and VEGF receptors...
January 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28214793/evaluation-of-timing-and-route-of-epinephrine-in-a-neonatal-model-of-asphyxial-arrest
#2
Payam Vali, Praveen Chandrasekharan, Munmun Rawat, Sylvia Gugino, Carmon Koenigsknecht, Justin Helman, William J Jusko, Bobby Mathew, Sara Berkelhamer, Jayasree Nair, Myra H Wyckoff, Satyan Lakshminrusimha
BACKGROUND: Epinephrine administered by low umbilical venous catheter (UVC) or endotracheal tube (ETT) is indicated in neonates who fail to respond to positive pressure ventilation and chest compressions at birth. Pharmacokinetics of ETT epinephrine via fluid-filled lungs or UVC epinephrine in the presence of fetal shunts is unknown. We hypothesized that epinephrine administered by ETT or low UVC results in plasma epinephrine concentrations and rates of return of spontaneous circulation (ROSC) similar to right atrial (RA) epinephrine...
February 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28214787/sparse-and-dense-hybrid-representation-via-subspace-modeling-for-dynamic-mri
#3
Qiegen Liu, Shanshan Wang, Dong Liang
Recent theoretical results on compressed sensing and low-rank matrix recovery have inspired significant interest in joint sparse and low rank modeling of dynamic magnetic resonance imaging (dMRI). Existing approaches usually describe these two respective prior information with different formulations. In this paper, we present a novel sparse and dense hybrid representation (SDR) model which describes the sparse plus low rank properties by a unified way. More specifically, under the learned dictionary consisting of temporal basis functions, SDR models the spatial coefficients in two subspaces with Laplacian and Gaussian prior distributions, respectively...
February 5, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28214537/biomechanical-behavior-of-endodontically-treated-premolars-using-different-preparation-designs-and-cad-cam-materials
#4
Diogo Pedrollo Lise, Annelies Van Ende, Jan De Munck, Thaís Yumi Umeda Suzuki, Luiz Clovis Cardoso Vieira, Bart Van Meerbeek
OBJECTIVES: To evaluate the effect of restoration design ('2.5-mm deep endocrown', '5-mm deep endocrown' or '5-mm deep post&crown') and CAD/CAM material type (composite or lithium disilicate glass-ceramic) on the load-to-failure of endodontically treated premolars in absence of any ferrule. METHODS: The crowns of 48 single-rooted premolars were cut and the roots were endodontically treated. Teeth were randomly divided into six groups (n=8); teeth in each group were restored using one of the two tested materials with standardized CAD/CAM fabricated endocrowns (with either 2...
February 15, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28214505/positional-right-ventricular-obstruction-in-pectus-excavatum
#5
Katherine Underwood, Matthew Vorsanger, Muhamed Saric, Adam H Skolnick
Pectus excavatum is one of the most common congenital chest wall deformities. The degree of sternal depression, which may result in compression of the right heart by the chest wall, is variable. While typically asymptomatic, there are various symptoms that can result from severe pectus excavatum. We report on a patient with severe pectus excavatum leading to dynamic obstruction of the right ventricular outflow tract in the seated position.
January 25, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28214491/relationship-between-patient-reported-symptoms-limitations-in-daily-activities-and-psychological-impact-in-varicose-veins
#6
Rajiv Mallick, Brajesh Kumar Lal, Claire Daugherty
OBJECTIVE: The objective of this study was to evaluate the relationship between patient-reported symptoms, functional limitations, and psychological impact of varicose veins (VVs) vs pathophysiologic mechanism, incorporating demographic and behavioral factors. METHODS: We conducted a pooled analysis from two clinical studies (Efficacy and Safety Study of Polidocanol Injectable Foam for the Treatment of Saphenofemoral Junction Incompetence [VANISH-1] and Polidocanol Endovenous Microfoam Versus Vehicle for the Treatment of Saphenofemoral Junction Incompetence [VANISH-2]) in patients with VVs (superficial venous reflux only)...
March 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28214489/ablation-of-the-great-saphenous-vein-with-nontumescent-n-butyl-cyanoacrylate-versus-endovenous-laser-therapy
#7
İsmail Koramaz, Helin El Kılıç, Fatih Gökalp, Macit Bitargil, Nilüfer Bektaş, Ersoy Engin, Mehmet Taşkın Egici, Ahmet Kürşat Bozkurt
OBJECTIVE: The endovenous application of n-butyl cyanoacrylate (NBCA) is a new nontumescent ablation technique for the treatment of venous insufficiency. The aim of this study was to retrospectively compare an NBCA-based ablation method with endovenous laser ablation (EVLA) for the management of incompetent great saphenous veins. METHODS: Between May 2013 and August 2014, there were 339 patients with incompetent varicose veins who were treated with either the endovenous application of NBCA (VariClose Vein Sealing System [VVSS]; Biolas, Ankara, Turkey) or EVLA...
March 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28214338/sciatic-neuropathy-due-to-popliteal-fossa-nerve-block
#8
Adam Aubuchon, W David Arnold, Anna Bracewell, J Chad Hoyle
INTRODUCTION: Sciatic neuropathy following popliteal nerve block (PNB) for regional anesthesia is considered uncommon but has been increasingly recognized in the literature. We identified a case of sciatic neuropathy that occurred after bunionectomy during which a PNB had been performed. METHODS: To understand the frequency of PNB-related sciatic neuropathy we performed a retrospective review of sciatic neuropathies at our center over a five year period. RESULTS: Forty-five cases of sciatic neuropathy were reviewed...
February 18, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28214143/retrospective-study-of-candida-sp-contaminations-of-endoscopes-at-the-university-hospital-of-tlemcen-algeria
#9
REVIEW
I Hassaine-Lahfa, Z Boucherit-Otmani, L Sari-Belkherroubi, K Boucherit
BACKGROUND: Improper cleaning and disinfection of endoscopes has been responsible for multiple nosocomial outbreaks and sometimes serious life-threatening infections. OBJECTIVE: The aim of our study is, at first, to identify Candida species responsible for the contamination of endoscopes, and to determine the minimal inhibitory concentrations of planktonic (MIC) and sessile cells (SMIC) of amphotericin B (AmB) against our isolated strains. MATERIALS AND METHODS: The present study was performed on four endoscopes in the department of gastroenterology at the University Hospital of Tlemcen (Algeria)...
February 14, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28213347/a-new-cheirolepidiaceae-coniferales-from-the-early-jurassic-of-patagonia-argentina-reconciling-the-records-of-impression-and-permineralized-fossils
#10
Ignacio Escapa, Andrew Leslie
PREMISE OF THE STUDY: Plants preserved in different fossil modes provide complementary data concerning the paleobiology and evolutionary relationships among plant groups. New material from the Early Jurassic of Patagonia shows the importance of combining these sources of information, as we describe the first compression/impression fossils of Pararaucaria, a genus of the extinct conifer family Cheirolepidiaceae previously known from permineralized fossils. These fossils extend the temporal range of this genus and may allow its wider recognition in the fossil record...
February 17, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28213338/a-uniaxial-cyclic-compression-method-for-characterizing-the-rheological-and-textural-behaviors-of-mechanically-dewatered-sewage-sludge
#11
Fenglin Liang, Martial Sauceau, Gilles Dusserre, Patricia Arlabosse
The mechanically dewatered sewage sludge with total solid content around 20% on a weight basis is very similar to yield stress fluid, its complex transition between solid and fluid states is not perfectly reversible and especially challenging in terms of pumping, land spreading and drying. To characterize the rheological and textural properties of highly concentrated sludge, a specific methodology based on uniaxial single and cyclic compression tests is developed. Three types of sludge samples (fresh original, fresh premixed and aged original ones) are extruded into cylinders and pressed between two parallel plates using a material testing machine...
February 7, 2017: Water Research
https://www.readbyqxmd.com/read/28213250/novel-electroanalytical-method-based-on-the-electrostriction-phenomenon-and-its-application-to-determination-of-cr-vi-by-the-flow-injection-technique
#12
Marcin Wieczorek, Jolanta Kochana, Paweł Knihnicki, Karolina Wapiennik, Paweł Kościelniak
The electrostriction phenomenon is observed in membranes of thickness in the nanometer range, e.g. bilayer lipid membranes or self-assembled monolayers. Strong electrical field of 105-106V/cm in intensity appears when applying the potential lower than 1V to these membranes. Electrostatic forces change the dimensions of a dielectric, hence the membrane compression and decrease in thickness are observed. As a result, increase in the membrane capacitance is recorded. The presented work covers development and application of a new analytical method based on the innovative capacitance-to-frequency conversion method and flow technique...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28213166/influence-of-clamping-stress-and-duration-on-the-trauma-of-liver-tissue-during-surgery-operation
#13
Jin Wang, Qing-Yuan Yu, Wei Li, Bing-Rui Wang, Zhong-Rong Zhou
BACKGROUND: Tissue grasping damage often occurs in minimally invasive surgery, which would increase the postoperative recovery time and the risk of surgical complications. The purpose of this study was to evaluate the relationship between liver tissue trauma and compression stress magnitude and duration during tissue clamping operation. METHODS: The clamping experiments of liver tissues in vivo were conducted by using a universal soft tissue mechanical testing machine under different clamping stress magnitudes and durations...
February 10, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28213129/cyclic-compressive-stress-induced-scinderin-regulates-progress-of-developmental-dysplasia-of-the-hip
#14
Cheng-Long Wang, Hui Wang, Fei Xiao, Chuan-Dong Wang, Guo-Li Hu, Jun-Feng Zhu, Chao Shen, Bin Zuo, Yi-Min Cui, De Li, Yuan-Gao, Xiao-Ling Zhang, Xiao-Dong Chen
Developmental dysplasia of the hip (DDH) is a common musculoskeletal disorder characterized by a mismatch between acetabulum and femoral head. Mechanical force plays an important role during the occurrence and development of abnormities in acetabulum and femoral head. In this study, we established a mechanical force model named cyclic compressive stress (Ccs). To analyze the effect of Ccs on DDH, we detected special genes in chondrocytes and osteoblasts. Results showed that Ccs downregulated chondrogenesis of ADTC5 in a concentration-dependent manner...
February 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28213100/effect-of-processing-conditions-of-dicalcium-phosphate-cements-on-graft-resorption-and-bone-formation
#15
Zeeshan Sheikh, Yu Ling Zhang, Faleh Tamimi, Jake Barralet
Dicalcium phosphate cements (brushite and monetite) are resorbable biomaterials with osteoconductive potential for bone repair and regeneration that have yet to gain widespread commercial use. Brushite can be converted to monetite by heat treatments additionally resulting in various changes in the physico-chemical properties. However, since conversion is most commonly performed using autoclave sterilisation (wet heating), it is uncertain whether the properties observed for monetite as a result of heating brushite under dry conditions affect resorption and bone formation favourably...
February 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28212858/refractive-index-and-thickness-determination-in-langmuir-monolayers-of-myelin-lipids
#16
Julio M Pusterla, Antonio A Malfatti-Gasperini, Ximena E Puentes-Martinez, Leide P Cavalcanti, Rafael G Oliveira
Langmuir monolayers at the air/water interface are widely used as biomembrane models and for amphiphilic molecules studies in general. Under controlled intermolecular organization (lateral molecular area), surface pressure, surface potential, reflectivity (R) and other magnitudes can be precisely determined on these planar monomolecular films. However, some physical parameters such as the refractive index of the monolayer (n) still remain elusive. The refractive index is very relevant because (in combination with R) it allows for the determination of the thickness of the film...
February 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28212488/graphene-oxide-glue-electrode-for-fabrication-of-vertical-elastic-conductive-columns
#17
Liusi Yang, Mingchu Zou, Shiting Wu, Wenjing Xu, Huaisheng Wu, Anyuan Cao
Graphene has a planar atomic structure with high flexibility, and might be used as ultra-thin conductive glues or adhesion layers in electronics and other applications. Here, we show that graphene oxide (GO) sheets condensed from solution can act as a pure, thin-layer, non-penetrating glue for fabrication of vertical architectures anchored on rigid and flexible substrates. Carbon nanotube (CNT) sponges are used as a porous template to make polymer-reinforced composite columns, to achieve both high conductivity and elastic behavior...
February 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/28212100/homotopy-methods-based-on-l%C3%A2-norm-for-compressed-sensing
#18
Zhengshan Dong, Wenxing Zhu
This paper proposes two homotopy methods for solving the compressed sensing (CS) problem, which combine the homotopy technique with the iterative hard thresholding (IHT) method. The homotopy methods overcome the difficulty of the IHT method on the choice of the regularization parameter value, by tracing solutions of the regularized problem along a homotopy path. We prove that any accumulation point of the sequences generated by the proposed homotopy methods is a feasible solution of the problem. We also show an upper bound on the sparsity level for each solution of the proposed methods...
February 15, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28212096/system-level-design-of-a-64-channel-low-power-neural-spike-recording-sensor
#19
Manuel Delgado-Restituto, Alberto Rodriguez-Perez, Angela Darie, Cristina Soto-Sanchez, Eduardo Fernandez-Jover, Angel Rodriguez-Vazquez
This paper reports an integrated 64-channel neural spike recording sensor, together with all the circuitry to process and configure the channels, process the neural data, transmit via a wireless link the information and receive the required instructions. Neural signals are acquired, filtered, digitized and compressed in the channels. Additionally, each channel implements an auto-calibration algorithm which individually configures the transfer characteristics of the recording site. The system has two transmission modes; in one case the information captured by the channels is sent as uncompressed raw data; in the other, feature vectors extracted from the detected neural spikes are released...
February 13, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28211890/local-melting-to-design-strong-and-plastically-deformable-bulk-metallic-glass-composites
#20
Yue-Sheng Qin, Xiao-Liang Han, Kai-Kai Song, Yu-Hao Tian, Chuan-Xiao Peng, Li Wang, Bao-An Sun, Gang Wang, Ivan Kaban, Jürgen Eckert
Recently, CuZr-based bulk metallic glass (BMG) composites reinforced by the TRIP (transformation-induced plasticity) effect have been explored in attempt to accomplish an optimal of trade-off between strength and ductility. However, the design of such BMG composites with advanced mechanical properties still remains a big challenge for materials engineering. In this work, we proposed a technique of instantaneously and locally arc-melting BMG plate to artificially induce the precipitation of B2 crystals in the glassy matrix and then to tune mechanical properties...
February 13, 2017: Scientific Reports
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