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https://www.readbyqxmd.com/read/28213108/intestinal-transport-and-absorption-of-bioactive-phenolic-compounds-from-a-chemically-characterized-aqueous-extract-of-athrixia-phylicoides
#1
Sandra L Bowles, Yonela Ntamo, Christiaan J Malherbe, Abidemi M P Kappo, Johan Louw, Christo J F Muller
ETHNOPHARMACOLOGICAL RELEVANCE: Athrixia phylicoides (A. phylicoides), popularly known as "bush tea", is an indigenous aromatic shrub found in mountainous and grassland areas of the northern and eastern parts of southern Africa. The plant is traditionally used for the treatment of several ailments, including coughing, treating infected wounds, treating boils and sore throat, hypertension and heart disease. Potential anti-diabetic effects have also been demonstrated in vitro. AIM OF THE STUDY: To investigate the intestinal transport of prominent phenolic constituents, across a fully differentiated Caco-2 monolayer, using a characterized aqueous extract of A...
February 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28143474/motivations-for-contralateral-prophylactic-mastectomy-as-a-function-of-socioeconomic-status
#2
Dadrie F Baptiste, Erina L MacGeorge, Maria K Venetis, Ashton Mouton, L Brooke Friley, Rebekah Pastor, Kristen Hatten, Janaka Lagoo, Susan E Clare, Monet W Bowling
BACKGROUND: Despite no demonstrated survival advantage for women at average risk of breast cancer, rates of contralateral prophylactic mastectomy (CPM) continue to increase. Research reveals women with higher socioeconomic status (SES) are more likely to select CPM. This study examines how indicators of SES, age, and disease severity affect CPM motivations. METHODS: Patients (N = 113) who underwent CPM at four Indiana University affiliated hospitals completed telephone interviews in 2013...
February 1, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28139394/serious-fall-injuries-before-and-after-initiation-of-hemodialysis-among-older-esrd-patients-in-the-united-states-a-retrospective-cohort-study
#3
Laura C Plantinga, Rachel E Patzer, Harold A Franch, C Barrett Bowling
BACKGROUND: Because initiation of dialysis therapy often occurs in the setting of acute illness and may signal worsening health and functional decline, we examined whether rates of serious fall injuries among older hemodialysis patients differ before and after dialysis therapy initiation. STUDY DESIGN: Retrospective cohort study of claims data from the 2 years spanning dialysis therapy initiation among patients initiating dialysis therapy in 2010 to 2012. SETTING & PARTICIPANTS: Claims from 81,653 Medicare end-stage renal disease beneficiaries aged 67 to 100 years...
January 27, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28095751/crispr-based-epigenome-editing-of-cytokine-receptors-for-the-promotion-of-cell-survival-and-tissue-deposition-in-inflammatory-environments
#4
Niloofar Farhang, Jonathan M Brunger, Joshua D Stover, Pratiksha I Thakore, Brandon Lawrence, Farshid Guilak, Charles A Gersbach, Lori A Setton, Robert D Bowles
Musculoskeletal diseases have been associated with inflammatory cytokine action, particularly action by TNF-α and IL-1β. These inflammatory cytokines promote apoptosis and senescence of cells in diseased tissue and extracellular matrix breakdown. Stem cell-based therapies are being considered for the treatment of musculoskeletal diseases, but the presence of these inflammatory cytokines will have similar deleterious action on therapeutic cells delivered to these environments. Methods that prevent inflammatory-induced apoptosis and pro-inflammatory signaling, in cell and pathway specific manners are needed...
January 17, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28062701/widespread-virus-replication-in-alveoli-drives-acute-respiratory-distress-syndrome-in-aerosolized-h5n1-influenza-infection-of-macaques
#5
Elizabeth R Wonderlich, Zachary D Swan, Stephanie J Bissel, Amy L Hartman, Jonathan P Carney, Katherine J O'Malley, Adebimpe O Obadan, Jefferson Santos, Reagan Walker, Timothy J Sturgeon, Lonnie J Frye, Pauline Maiello, Charles A Scanga, Jennifer D Bowling, Anthea L Bouwer, Parichat A Duangkhae, Clayton A Wiley, JoAnne L Flynn, Jieru Wang, Kelly S Cole, Daniel R Perez, Douglas S Reed, Simon M Barratt-Boyes
Human infections with highly pathogenic avian influenza A (H5N1) virus are frequently fatal but the mechanisms of disease remain ill-defined. H5N1 infection is associated with intense production of proinflammatory cytokines, but whether this cytokine storm is the main cause of fatality or is a consequence of extensive virus replication that itself drives disease remains controversial. Conventional intratracheal inoculation of a liquid suspension of H5N1 influenza virus in nonhuman primates likely results in efficient clearance of virus within the upper respiratory tract and rarely produces severe disease...
February 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28049638/leukemic-blasts-program-bone-marrow-adipocytes-to-generate-a-pro-tumoral-microenvironment
#6
Manar S Shafat, Thomas Oellerich, Sebastian Mohr, Stephen D Robinson, Dylan R Edwards, Christopher R Marlein, Rachel E Piddock, Matthew Fenech, Lyubov Zaitseva, Amina Abdul-Aziz, Jeremy Turner, Johnathan A Watkins, Matthew Lawes, Kristian M Bowles, Stuart A Rushworth
Despite currently available therapies most patients diagnosed with acute myeloid leukemia (AML) die of their disease. Tumor-host interactions are critical for the survival and proliferation of cancer cells; accordingly, we hypothesise that specific targeting of the tumor microenvironment may constitute an alternative or additional strategy to conventional tumor-directed chemotherapy. Since adipocytes have been shown to promote breast and prostate cancer proliferation, and because the bone marrow adipose tissue (MAT) accounts for up to 70% of bone marrow volume in adult humans, we examined the adipocyte-leukaemia cell interactions to determine if they are essential for the growth and survival of AML...
January 3, 2017: Blood
https://www.readbyqxmd.com/read/28033165/developing-an-adapted-cardiac-rehabilitation-training-for-home-care-clinicians-patient-perspectives-clinician-knowledge-and-curriculum-overview
#7
Jodi L Feinberg, David Russell, Ana Mola, Kathryn H Bowles, Terri H Lipman
PURPOSE: There is limited evidence that home care clinicians receive education on the core competencies of cardiac rehabilitation (CR). This article describes the development and implementation of a CR training program adapted for home care clinicians, which incorporated the viewpoints of homebound patients with cardiovascular disease. METHODS: Literature and guideline reviews were performed to glean curriculum content, supplemented with themes identified among patients and clinicians...
December 28, 2016: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/27992946/balloon-tuboplasty-in-patients-with-eustachian-tube-dysfunction-a-prospective-study-in-39-patients-55-ears
#8
P F Bowles, S Agrawal, M A Salam
No abstract text is available yet for this article.
December 19, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27988204/smad-transcription-factors-are-altered-in-cell-models-of-hd-and-regulate-htt-expression
#9
K R Bowles, T Stone, P Holmans, N D Allen, S B Dunnett, L Jones
Transcriptional dysregulation is observable in multiple animal and cell models of Huntington's disease, as well as in human blood and post-mortem caudate. This contributes to HD pathogenesis, although the exact mechanism by which this occurs is unknown. We therefore utilised a dynamic model in order to determine the differential effect of growth factor stimulation on gene expression, to highlight potential alterations in kinase signalling pathways that may be in part responsible for the transcriptional dysregulation observed in HD, and which may reveal new therapeutic targets...
February 2017: Cellular Signalling
https://www.readbyqxmd.com/read/27970640/fore-sweeping-generalisations-do-not-bowl-over-all-cultures%C3%A2-cultural-adaptation-in-the-kidney-disease-quality-of-life-questionnaire
#10
A Richards, H Mead, L Towns
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27898576/sexually-transmitted-disease-testing-and-uptake-of-human-papillomavirus-vaccine-in-a-large-online-survey-of-us-men-who-have-sex-with-men-at-risk-for-hiv-infection-2012
#11
Erin M Kahle, Elissa Meites, R Craig Sineath, Muazzam Nasrullah, Kristina E Bowles, Elizabeth DiNenno, Patrick S Sullivan, Travis Sanchez
National guidelines recommend annual human immunodeficiency virus (HIV)/sexually transmitted disease testing for sexually active men who have sex with men (MSM) and vaccination against human papillomavirus for MSM through age 26. A 2012 online survey of 2,794 MSM found that 51%, 36%, and 14% reported receiving human immunodeficiency virus testing, sexually transmitted disease testing, and human papillomavirus vaccination, respectively.
January 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27880003/association-of-multimorbidity-with-mortality-and-healthcare-utilization-in-chronic-kidney-disease
#12
C Barrett Bowling, Laura Plantinga, Lawrence S Phillips, William McClellan, Katharina Echt, Neale Chumbler, Gerald McGwin, Ann Vandenberg, Richard M Allman, Theodore M Johnson
OBJECTIVES: Chronic kidney disease (CKD) almost universally occurs in individuals with other medical problems. However, few studies have described CKD-related multimorbidity using a framework that identifies chronic conditions as concordant (having overlap in treatment goals) versus discordant (having opposing treatment recommendations) and unrelated (having no overlap, but contributing to complexity via different resource requirements). DESIGN: Retrospective cohort...
November 23, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27803069/insurance-based-differences-in-time-to-diagnostic-follow-up-after-positive-screening-mammography
#13
Danielle D Durham, Whitney R Robinson, Sheila S Lee, Stephanie B Wheeler, Katherine E Reeder-Hayes, J Michael Bowling, Andrew F Olshan, Louise M Henderson
BACKGROUND: Insurance may lengthen or inhibit time to follow-up after positive screening mammography. We assessed the association between insurance status and time to initial diagnostic follow-up after a positive screening mammogram. METHODS: Using 1995-2010 data from a North Carolina population-based registry of breast imaging and cancer outcomes, we identified women with a positive screening mammogram. We compared receipt of follow-up within 60 days of screening using logistic regression and evaluated time to follow-up initiation using Cox proportional hazards regression...
November 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27793632/radioguided-surgery-and-the-gostt-concept-from-pre-operative-image-and-intraoperative-navigation-to-image-assisted-excision
#14
H Bowles, N Sánchez, A Tapias, P Paredes, F Campos, C Bluemel, R A Valdés Olmos, S Vidal-Sicart
Radio-guided surgery has been developed for application in those disease scheduled for surgical management, particularly in areas of complex anatomy. This is based on the use of pre-operative scintigraphic planar, tomographic and fused SPECT/CT images, and the possibility of 3D reconstruction for the subsequent intraoperative locating of active lesions using handheld devices (detection probes, gamma cameras, etc.). New tracers and technologies have also been incorporated into these surgical procedures. The combination of visual and acoustic signals during the intraoperative procedure has become possible with new portable imaging modalities...
October 25, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/27754286/br-07-1-development-of-the-cell-microarray-for-high-throughput-analysis-of-gut-microbiota
#15
Seong-Tshool Hong
The human intestine contains a massive and complex microbial community called gut microbiota. A typical human carries 100 trillion microbes in his/her body which is 10 times greater than the number of their host cells, i.e. whole number of human cells. A combined microbial genome constituting gut microbiota is well excess our own human genome. The microbial composition of gut microbiotata and its role on diseases became a booming area of research, presenting a new paradigm of opportunities for modern medicines...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27733436/association-of-nondisease-specific-problems-with-mortality-long-term-care-and-functional-impairment-among-older-adults-who-require-skilled-nursing-care-after-dialysis-initiation
#16
C Barrett Bowling, Laura Plantinga, Rasheeda K Hall, Anna Mirk, Rebecca Zhang, Nancy Kutner
BACKGROUND AND OBJECTIVES: The majority of older adults who initiate dialysis do so during a hospitalization, and these patients may require post-acute skilled nursing facility (SNF) care. For these patients, a focus on nondisease-specific problems, including cognitive impairment, depressive symptoms, exhaustion, falls, impaired mobility, and polypharmacy, may be more relevant to outcomes than the traditional disease-oriented approach. However, the association of the burden of nondisease-specific problems with mortality, transition to long-term care (LTC), and functional impairment among older adults receiving SNF care after dialysis initiation has not been studied...
December 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27733015/adipose-stromal-vascular-fraction-mediated-improvements-at-late-stage-disease-in-a-murine-model-of-multiple-sclerosis
#17
Annie C Bowles, Amy L Strong, Rachel M Wise, Robert C Thomas, Brittany Y Gerstein, Maria F Dutreil, Ryan S Hunter, Jeffrey M Gimble, Bruce A Bunnell
Multiple sclerosis (MS) is a common neurodegenerative disease and remains an unmet clinical challenge. In MS, an autoimmune response leads to immune cell infiltration, inflammation, demyelination, and lesions in central nervous system (CNS) tissues resulting in tremors, fatigue, and progressive loss of motor function. These pathologic hallmarks are effectively reproduced in the murine experimental autoimmune encephalomyelitis (EAE) model. The stromal vascular fraction (SVF) of adipose tissue is composed of adipose-derived stromal/stem cells (ASC), adipocytes, and various leukocytes...
October 12, 2016: Stem Cells
https://www.readbyqxmd.com/read/27727461/a-comparison-of-overall-survival-for-patients-with-t4-larynx-cancer-treated-with-surgical-versus-organ-preservation-approaches-a-national-cancer-data-base-analysis
#18
William A Stokes, Bernard L Jones, Shilpa Bhatia, Ayman J Oweida, Daniel W Bowles, David Raben, Julie A Goddard, Jessica D McDermott, Sana D Karam
BACKGROUND: Although laryngectomy is the treatment of choice for patients with T4 larynx cancer, many patients are unable or unwilling to undergo laryngectomy and instead pursue larynx-preservation strategies combining radiotherapy (RT) and chemotherapy. Herein, the authors analyzed the National Cancer Data Base to evaluate overall survival (OS) between patients treated with surgical and organ-preserving modalities. METHODS: The National Cancer Data Base was queried for patients diagnosed from 2004 through 2012 with T4M0 laryngeal cancer who underwent either laryngectomy (surgery) with adjuvant RT (SRT), chemotherapy starting concurrently within 7 days of RT (CCRT), or multiagent induction chemotherapy starting 43 to 98 days before RT (ICRT)...
October 11, 2016: Cancer
https://www.readbyqxmd.com/read/27694559/effects-of-singing-bowl-sound-meditation-on-mood-tension-and-well-being-an-observational-study
#19
Tamara L Goldsby, Michael E Goldsby, Mary McWalters, Paul J Mills
Poor mood and elevated anxiety are linked to increased incidence of disease. This study examined the effects of sound meditation, specifically Tibetan singing bowl meditation, on mood, anxiety, pain, and spiritual well-being. Sixty-two women and men (mean age 49.7 years) participated. As compared with pre-meditation, following the sound meditation participants reported significantly less tension, anger, fatigue, and depressed mood (all Ps <.001). Additionally, participants who were previously naïve to this type of meditation experienced a significantly greater reduction in tension compared with participants experienced in this meditation (P < ...
September 30, 2016: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/27668855/automated-identification-of-wound-information-in-clinical-notes-of-patients-with-heart-diseases-developing-and-validating-a-natural-language-processing-application
#20
Maxim Topaz, Kenneth Lai, Dawn Dowding, Victor J Lei, Anna Zisberg, Kathryn H Bowles, Li Zhou
BACKGROUND: Electronic health records are being increasingly used by nurses with up to 80% of the health data recorded as free text. However, only a few studies have developed nursing-relevant tools that help busy clinicians to identify information they need at the point of care. OBJECTIVE: This study developed and validated one of the first automated natural language processing applications to extract wound information (wound type, pressure ulcer stage, wound size, anatomic location, and wound treatment) from free text clinical notes...
December 2016: International Journal of Nursing Studies
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