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https://www.readbyqxmd.com/read/27863159/state-of-the-evidence-cannabinoids-and-cancer-pain-a-systematic-review
#1
Sydney Tateo
BACKGROUND AND PURPOSE: Cannabinoids are widely used to alleviate intractable symptoms such as pain, nausea, and muscle spasticity. The purpose of this review was to ascertain the current state of the science regarding use of cannabinoids for cancer pain. METHODS: Four electronic databases were searched for randomized control trials of cannabinoids and cancer pain. Studies included examined the analgesic effects of cannabinoids for cancer pain. Methodological quality was assessed using the Jadad scale...
November 10, 2016: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/27812971/efficacy-and-safety-of-dexmedetomidine-as-an-adjuvant-in-epidural-analgesia-and-anesthesia-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Xu Zhang, Dong Wang, Min Shi, YuanGuo Luo
BACKGROUND AND OBJECTIVE: Several clinical trials have examined and indicated the usefulness of epidural dexmedetomidine therapy. However, there has been no systematic analysis of the findings of these trials to date. We undertook this systematic review and meta-analysis to investigate the efficacy and safety of epidural dexmedetomidine adjunctive therapy in different surgical procedures. MATERIALS AND METHODS: We searched EMBASE, PubMed, the Cochrane Library, and the Clinical Trials...
November 4, 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27765547/does-psychological-profile-influence-third-molar-extraction-and-postoperative-pain
#3
Raquel González-Martínez, María Del Mar Jovani-Sancho, Isidoro Cortell-Ballester
PURPOSE: Our purposes were to determine the influence of psychological profile on hemodynamic changes in patients who undergo surgical removal of the third molars under intravenous sedation and to evaluate the effect on patients' anxiety and postoperative recovery. PATIENTS AND METHODS: We performed a prospective study of 100 patients (American Society of Anesthesiologists classes I and II; aged ≥18 years) seen in the CIMIVClinic (Department of Oral Surgery, Casa de Salud University Hospital, Valencia, Spain) who underwent extractions of all third molars under intravenous sedation...
September 22, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27755490/effect-of-topical-morphine-on-acute-and-chronic-postmastectomy-pain-what-is-the-optimum-dose
#4
Sahar Abdel-Baky Mohamed, Hala Saad Abdel-Ghaffar, Shereen Mamdouh Kamal, Khaled Mohamed Fares, Hesham Mahmoud Hamza
BACKGROUND AND OBJECTIVES: Poorly controlled postoperative pain is strongly associated with the development of chronic pain. We aimed to investigate the effect of topical morphine (in 1 of 3 doses: 5, 10, or 15 mg) on acute and chronic neuropathic pain after modified radical mastectomy for cancer breast. METHODS: In this registered clinical trial (ClinicalTrials.gov identifier: NCT02462577), 90 patients were allocated to receive 10 mL plain bupivacaine 0.5% plus either 5, 10, or 15 mg morphine (designated by the group names Morphine5, Morphine10, and Morphine15, respectively)...
October 11, 2016: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27636926/-efficacy-of-kolofort-for-the-treatment-of-patients-with-irritable-bowel-syndrome
#5
V V Tsukanov, O S Rzhavicheva, A V Vasyutin, O V Dunaevskaya, Yu L Tonkikh, E P Bronnikova
AIM: to determine the efficacy and safety of Kolofort in the treatment of patients with irritable bowel syndrome (IBS). SUBJECTS AND METHODS: 52 patients (16 men and 36 women) aged 26 to 59 years were examined over 4 months to rule out organic disease. The diagnosis of IBS was established on the basis of the Rome III diagnostic criteria (2006). Seven patients were diagnosed as having IBS with a preponderance of constipation; 3 had IBS with a preponderance of diarrhea, and 42 had mixed IBS...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27618967/prevention-of-catheter-related-bladder-discomfort-pudendal-nerve-block-with-ropivacaine-versus-intravenous-tramadol-study-protocol-for-a-randomized-controlled-trial
#6
Jing-Yi Li, Ren Liao
BACKGROUND: Catheter-related bladder discomfort (CRBD) is a common distressing symptom complex during the postoperative period, especially after urologic procedures with a relatively greater size urinary catheter. In this study, we will enroll male patients undergoing elective prostate surgery with urinary catheterization under general anesthesia, and we will compare the efficacy of pudendal nerve block (PNB) and intravenous tramadol in CRBD prevention. METHODS/DESIGN: This trial is a prospective, randomized controlled trial that will test the superiority of bilateral PNB with 0...
September 13, 2016: Trials
https://www.readbyqxmd.com/read/27475408/factors-associated-with-having-a-medical-marijuana-card-among-veterans-with-recent-substance-use-in-va-outpatient-treatment
#7
Alan K Davis, Erin E Bonar, Mark A Ilgen, Maureen A Walton, Brian E Perron, Stephen T Chermack
Psychiatric symptoms, somatic problems, and co-occurring substance use have been associated with medical marijuana consumption among civilian patients with substance use disorders. It is possible that these factors may impact Veterans' ability to engage in or adhere to mental health and substance use disorder treatment. Therefore, we examined whether psychiatric functioning, substance use, and somatic problems were associated with medical marijuana use among Veterans receiving substance use disorder and/or mental health treatment...
December 2016: Addictive Behaviors
https://www.readbyqxmd.com/read/27350217/nefopam-a-non-opioid-analgesic-does-not-alleviate-experimental-work-effort-dyspnoea-in-healthy-humans-a-randomised-controlled-trial
#8
Laurence Dangers, Louis Laviolette, Bény Charbit, Thomas Similowski, Capucine Morélot-Panzini
BACKGROUND: Dyspnoea is a distressing and debilitating symptom with a major impact on quality of life. Alleviation of dyspnoea therefore constitutes a major clinical challenge. When causative physiological disorders cannot be corrected ("persistent dyspnoea"), nonspecific treatment must be considered. Morphine alleviates dyspnoea but has numerous side-effects including ventilatory depression, which justifies looking for alternatives. Certain forms of dyspnoea involve C-fibres, and can be attenuated by C-fibres blockade...
August 2016: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27082620/dorsal-penile-nerve-block-with-ropivacaine-reduced-postoperative-catheter-related-bladder-discomfort-in-male-patients-after-emergence-of-general-anesthesia-a-prospective-randomized-controlled-study
#9
RANDOMIZED CONTROLLED TRIAL
Jing-yi Li, Ming-liang Yi, Ren Liao
Catheter-related bladder discomfort (CRBD) is a distressing symptom complex after surgery, especially in male patients who have had urinary catheterization under general anesthesia. In this prospective, randomized, controlled trial, we compared dorsal penile nerve block (DPNB) with 0.33% ropivacaine with intravenous tramadol 1.5 mg kg(-1) in prevention of CRBD, as well as the incidences of postoperative side effects. Fifty-eight male patients aged 18 to 50 years, undergoing elective liver surgery and limb surgery with urinary catheterization, were enrolled and divided randomly into 2 groups...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26804064/effects-of-a-stepwise-multidisciplinary-intervention-for-challenging-behavior-in-advanced-dementia-a-cluster-randomized-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Marjoleine J C Pieper, Anneke L Francke, Jenny T van der Steen, Erik J A Scherder, Jos W R Twisk, Christine R Kovach, Wilco P Achterberg
OBJECTIVES: To assess whether implementation of a stepwise multicomponent intervention (STA OP!) is effective in reducing challenging behavior and depression in nursing home residents with advanced dementia. DESIGN: Cluster randomized controlled trial. SETTING: Twenty-one clusters (single independent nursing home units) in 12 nursing homes within the Netherlands. PARTICIPANTS: Residents with advanced dementia (N = 288)...
February 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/26645318/a-study-on-the-effects-of-sympathetic-skin-response-parameters-in-diagnosis-of-fibromyalgia-using-artificial-neural-networks
#11
Ozhan Ozkan, Murat Yildiz, Evren Arslan, Sedat Yildiz, Suleyman Bilgin, Selami Akkus, Hasan R Koyuncuoglu, Etem Koklukaya
Fibromyalgia syndrome (FMS), usually observed commonly in females over age 30, is a rheumatic disease accompanied by extensive chronic pain. In the diagnosis of the disease non-objective psychological tests and physiological tests and laboratory test results are evaluated and clinical experiences stand out. However, these tests are insufficient in differentiating FMS with similar diseases that demonstrate symptoms of extensive pain. Thus, objective tests that would help the diagnosis are needed. This study analyzes the effect of sympathetic skin response (SSR) parameters on the auxiliary tests used in FMS diagnosis, the laboratory tests and physiological tests...
March 2016: Journal of Medical Systems
https://www.readbyqxmd.com/read/26620768/local-anaesthesia-and-conscious-sedation-for-cochlear-implantation-experience-with-20-patients
#12
COMPARATIVE STUDY
B Pateron, D Bakhos, A LeLouarn, P Bordure, A Bozorg Grayeli, B Godey, E Lescanne
OBJECTIVE: Cochlear implantation is mostly performed under general anaesthesia. This study aimed to evaluate cochlear implantation performed under local anaesthesia and sedation. METHOD: Twenty patients had a cochlear implant fitted under combined local anaesthesia (local anaesthesia group) and 41 patients had one fitted under general anaesthesia (general anaesthesia group) for bilateral profound hearing loss, from 2011 to 2014. Surgical duration, period of post-operative hospitalisation and early post-operative symptoms were compared...
February 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/26591225/-application-of-dexmedetomidin-for-sedation-of-patients-in-alcohol-withdrawal-state-in-the-icu
#13
K Yu Belka
The efficacy and safety of sedation on 44 patients in alcohol withdrawal state (AWS) for use of intravenous dexmedetomidine infusion. Dexmedetomidine increased the duration of target sedation level to 20%, decreased the duration of excessive/insufficient sedation to 10%, it was associated with AWS symptoms regression, better communication with the patient, reduced consumption of benzodiazepines (BZD) from 40 to 30 mg per day and antypsihotics for control AWS symptoms. The common complications of dexmedetomidine infusion were bradycardia and hypotension...
July 2015: Klinichna Khirurhiia
https://www.readbyqxmd.com/read/26543063/a-survey-of-hospice-and-palliative-care-physicians-regarding-palliative-sedation-practices
#14
Michael R Lux, Bridget McCrate Protus, Jason Kimbrel, Phyllis Grauer
CONTEXT: Patients nearing the end of life may experience symptoms that are refractory to standard therapeutic options. Physicians may consider palliative sedation to relieve intolerable suffering. There is limited clinical literature regarding preferred medications for palliative sedation. OBJECTIVES: To determine the preferred medications physicians use when implementing palliative sedation. METHODS: An Internet-based, cross-sectional survey of hospice and palliative care physicians in the United States...
November 5, 2015: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/26461076/opioid-related-endocrinopathy
#15
REVIEW
Jeffrey A Gudin, Adam Laitman, Srinivas Nalamachu
OBJECTIVE: Millions of patients continue to require opioid analgesics for control of moderate to severe chronic pain, which is a disease that affects more Americans than cancer, heart disease, and diabetes combined. Common opioid adverse effects include constipation, sedation, and nausea. A lesser-known sequelae is opioid induced androgen deficiency (OPIAD). The objective of this review was to better characterize the effects of opioids on the endocrine system. METHODS: Published data were evaluated to identify links between opioid use and hypogonadism, as well as to describe proposed physiological mechanisms...
October 2015: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/26396499/clinically-significant-drug-drug-interactions-involving-opioid-analgesics-used-for-pain-treatment-in-patients-with-cancer-a-systematic-review
#16
REVIEW
Aleksandra Kotlinska-Lemieszek, Pål Klepstad, Dagny Faksvåg Haugen
BACKGROUND: Opioids are the most frequently used drugs to treat pain in cancer patients. In some patients, however, opioids can cause adverse effects and drug-drug interactions. No advice concerning the combination of opioids and other drugs is given in the current European guidelines. OBJECTIVE: To identify studies that report clinically significant drug-drug interactions involving opioids used for pain treatment in adult cancer patients. DESIGN AND DATA SOURCES: Systematic review with searches in Embase, MEDLINE, and Cochrane Central Register of Controlled Trials from the start of the databases (Embase from 1980) through January 2014...
2015: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/26267745/association-of-total-serum-antioxidant-capacity-with-the-tei-index-in-echocardiography-in-patients-with-microvascular-angina
#17
Alparslan Kilic, Mikail Yarlioglues, Ebru Akgul Ercan, Mustafa Duran, Murat Ugurlu, Fatih Oksuz, Sedat Ozdemir, Alparslan Kurtul, Muhammed Karadeniz, Sani Namik Murat, Sule Korkmaz, Selda Demirtas
OBJECTIVES: Cardiac syndrome X (CSX) is a condition characterized by exercise-induced chest pain that occurs considering a normal coronary angiogram. We aimed to investigate the total serum antioxidant capacity (TAC) and biventricular global functions using echocardiography in patients with CSX. PATIENTS AND METHODS: The study population included 55 patients with typical anginal symptoms and a positive exercise stress test, or ischemia in myocardial perfusion scintigraphy and normal coronary arteries detected angiographically, and 49 healthy volunteers with atypical chest pain and a negative stress test...
November 2015: Coronary Artery Disease
https://www.readbyqxmd.com/read/26247911/correlates-of-residual-fatigue-in-patients-with-major-depressive-disorder-the-role-of-psychotropic-medication
#18
Ka-Fai Chung, Yee-Man Yu, Wing-Fai Yeung
OBJECTIVE: Fatigue is not only a core symptom of major depressive disorder (MDD), but also a common residual symptom. We determined the sociodemographic, clinical, and pharmacologic factors that were associated with fatigue in patients with remission or partial remission of MDD. METHODS: Data was derived from a randomized controlled trial of acupuncture in 137 MDD patients with residual symptoms. Fatigue was measured by Multidimensional Fatigue Inventory (MFI-20)...
November 1, 2015: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26244836/long-term-intermittent-palliative-sedation-for-refractory-symptoms-at-the-end-of-life-in-two-cancer-patients
#19
Haa-Na Song, Un Seok Lee, Gyeong-Won Lee, In Gyu Hwang, Jung Hun Kang, Bruera Eduardo
BACKGROUND: Palliative sedation (PS) can be classified as either continuous or intermittent. Continuous PS is most commonly used in end-of-life care, while no specific indication for intermittent PS exists. CASE PRESENTATION: Here we describe two cases of refractory severe cancer pain with psychological anguish that were controlled successfully by intermittent IPS for the long time. One patient complained of refractory severe cancer pain and insomnia. The other patient had uncontrollable pain and delirium, whose sufferings were relieved by intermittent PS...
September 2015: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/26132060/continuous-sedation-until-death-should-not-be-an-option-of-first-resort
#20
COMMENT
Susan D McCammon, Nicole M Piemonte
Samuel H. LiPuma and Joseph P. DeMarco argue for a positive right to continuous sedation until death (CSD) for any patient with a life expectancy less than six months. They reject any requirement of proportionality. Their proposed guideline makes CSD an option for a decisional adult patient with an appropriate terminal diagnosis regardless of whether suffering (physical or existential) is present. This guideline purports to "empower" the patient with the ability to control the timing and manner of her death...
2015: Journal of Clinical Ethics
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