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https://www.readbyqxmd.com/read/28221979/influence-of-transportation-conditions-and-postharvest-disinfection-treatments-on-microbiological-quality-of-fresh-market-tomatoes-cv-nemo-netta-in-a-south-african-supply-chain
#1
M S Sibomana, L W Ziena, S Schmidt, T S Workneh
Postharvest microbial spoilage due to suboptimal transportation and packaging conditions is a key concern for the South African tomato industry. This study investigated the influence of washing with tap water or aqueous disinfectant solutions (chlorinated and anolyte water) on the microbiological quality of tomatoes during storage after transportation in nonrefrigerated trucks along two supply routes when packaged in crates and boxes. Route 1 was 1,093 km from field to storage site, while route 2 was 1,057 km...
February 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28202068/the-dna-damage-response-promotes-polyomavirus-jc-infection-by-nucleus-to-cytoplasm-nf-kappab-activation
#2
Martyn K White, Anna Bellizzi, Gabriele Ibba, Valeria Pietropaolo, Anna T Palamara, Hassen S Wollebo
BACKGROUND: Infection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular DNA. This activates DNA damage response (DDR) signaling including induction of expression of DNA repair factor Rad51. We previously reported that Rad51 co-operates with the transcription factor NF-κB p65 to activate JCV early transcription. Thus Rad51 induction by JCV infection may provide positive feedback for viral activation early in JCV infection...
February 15, 2017: Virology Journal
https://www.readbyqxmd.com/read/28192730/inducible-turnover-of-optineurin-regulates-t-cell-activation
#3
Angela Montecalvo, Simon C Watkins, Jordan Orange, Lawrence P Kane
Optineurin (Optn) is an adaptor protein with homology to NF-κB essential modulator (NEMO), the regulatory subunit of the IκB kinase (IKK) complex. Dysregulation of Optn has been linked to neurodegenerative, autoimmune and bone diseases. Optn shares a high degree of homology with NEMO, but is not part of the same high-molecular weight complex containing IKKα and IKKβ. Despite its homology with NEMO and the fact that it has been the subject of extensive study in several cell types, there are no published studies addressing the role of Optn during T cell activation...
February 10, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28185954/wip1-directly-dephosphorylates-nlk-and-increases-wnt-activity-during-germ-cell-development
#4
Seung-Ju Cho, Bok-Sik Cha, Ok-Seon Kwon, Jisun Lim, Dong-Myung Shin, Dong Wook Han, Tohru Ishitani, Eek-Hoon Jho, Albert J Fornace, Hyuk-Jin Cha
Mice null for wild-type p53-induced phosphatase 1 (WIP1) display defects in testis development and spermatogenesis, resulting in reduced fertility. However, the molecular mechanism underlying these abnormalities in the testis remains uncharacterized. We report that the phosphatase activity of WIP1 increases Wnt activity through Nemo-like kinase (NLK). WIP1 directly interacted with NLK, which is highly homologous to p38 MAPK, a WIP1 substrate, and dephosphorylated its activation site. The WIP1-mediated inhibition of NLK activity markedly decreased the phosphorylation of lymphoid enhancer-binding factor 1 (LEF1), disrupting its interaction with β-catenin...
February 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28181378/sacral-nerve-stimulation-can-alleviate-symptoms-of-bowel-dysfunction-after-colorectal-resections
#5
Diane Mege, Guillaume Meurette, Veronique Vitton, Anne-Marie Leroi, Valerie Bridoux, Philippe Zerbib, Igor Sielezneff
BACKGROUND: Poor functional results, such as faecal incontinence (FI), low anterior resection syndrome (LARS) or high stool frequency can occur after colorectal resections; including proctocolectomy with ileal pouch-anal anastomosis (IPAA), rectal resection and left hemicolectomy. Management of these patients is an issue, and some case-reports have demonstrated the effectiveness of sacral nerve stimulation (SNS) in such situations. OUR AIM: was to analyse the effectiveness of SNS on poor functional results and on the quality of life, after different colorectal resections...
February 9, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28165393/reduced-sharpin-and-lubac-formation-may-contribute-to-ccl%C3%A2-or-acetaminophen-induced-liver-cirrhosis-in-mice
#6
Takeshi Yamamotoya, Yusuke Nakatsu, Yasuka Matsunaga, Toshiaki Fukushima, Hiroki Yamazaki, Sunao Kaneko, Midori Fujishiro, Takako Kikuchi, Akifumi Kushiyama, Fuminori Tokunaga, Tomoichiro Asano, Hideyuki Sakoda
Linear ubiquitin chain assembly complex (LUBAC), composed of SHARPIN (SHANK-associated RH domain-interacting protein), HOIL-1L (longer isoform of heme-oxidized iron-regulatory protein 2 ubiquitin ligase-1), and HOIP (HOIL-1L interacting protein), forms linear ubiquitin on nuclear factor-κB (NF-κB) essential modulator (NEMO) and induces NF-κB pathway activation. SHARPIN expression and LUBAC formation were significantly reduced in the livers of mice 24 h after the injection of either carbon tetrachloride (CCl₄) or acetaminophen (APAP), both of which produced the fulminant hepatitis phenotype...
February 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28113347/nemo-an-evolutionary-model-with-modularity-for-ppi-networks
#7
Min Ye, Xiuwei Zhang, Gabriela C Racz, Qijia Jiang, Bernard M E Moret
Modelling the evolution of biological networks is a major challenge. Biological networks are usually represented as graphs; evolutionary events include addition and removal of vertices and edges, but also duplication of vertices and their associated edges. Since duplication is viewed as a primary driver of genomic evolution, recent work has focused on duplication-based models. Missing from these models is any embodiment of modularity, a widely accepted attribute of biological networks. Some models spontaneously generate modular structures, but none is known to maintain and evolve them...
January 19, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28095323/pattern-recognitions-receptors-in-immunodeficiency-disorders
#8
Esameil Mortaz, Ian M Adcock, Payam Tabarsi, Ilad Alavi Darazam, Masoud Movassaghi, Johan Garssen, Hamidreza Jamaati, Aliakbar Velayati
Pattern recognition receptors (PRRs) recognize common microbial or host-derived macromolecules and have important roles in early activation and response of the immune system. Initiation of the innate immune response starts with the recognition of microbial structures called pathogen associated molecular patterns (PAMPs). Recognition of PAMPs is performed by germline-encoded receptors expressed mainly on immune cells termed pattern recognition receptors (PRRs). Several classes of pattern recognition receptors (PRRs) are involved in the pathogenesis of diseases, including Toll-like receptors (TLRs), C-type lectin receptors (CLRs), and Nod-like receptors (NLRs)...
January 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28052234/exploring-polyubiquitin-as-a-flexible-multiple-ligand-binding-platform
#9
David Fushman
Linear (head-to-tail linked) polyubiquitin chains play a key role in the regulation of NF-κB signaling. In this issue of Structure, Lin et al. (2017) shed light on how linear tri-ubiquitin binds to ABIN2, a molecule that shares ubiquitin-binding properties of NEMO, the key activator of NF-κB.
January 3, 2017: Structure
https://www.readbyqxmd.com/read/28035815/binding-site-configurations-probe-the-structure-and-dynamics-of-the-zinc-finger-of-nemo-nf-%C3%AE%C2%BAb-essential-modulator
#10
Ryan C Godwin, Ryan L Melvin, William H Gmeiner, Freddie R Salsbury
Zinc-finger proteins are regulators of critical signaling pathways for various cellular functions, including apoptosis and oncogenesis. Here, we investigate how binding site protonation states and zinc coordination influence protein structure, dynamics, and ultimately function, as these pivotal regulatory proteins are increasingly important for protein engineering and therapeutic discovery. To better understand the thermodynamics and dynamics of the zinc finger of NEMO (NF-κB essential modulator), as well as the role of zinc, we present results of 20 μs molecular dynamics trajectories, 5 μs for each of four active site configurations...
January 13, 2017: Biochemistry
https://www.readbyqxmd.com/read/28035784/enhancing-the-cell-permeability-and-metabolic-stability-of-peptidyl-drugs-by-reversible-bicyclization
#11
Ziqing Qian, Curran A Rhodes, Lucas C McCroskey, Jin Wen, George Appiah-Kubi, David J Wang, Denis C Guttridge, Dehua Pei
Therapeutic applications of peptides are currently limited by their proteolytic instability and impermeability to the cell membrane. A general, reversible bicyclization strategy is now reported to increase both the proteolytic stability and cell permeability of peptidyl drugs. A peptide drug is fused with a short cell-penetrating motif and converted into a conformationally constrained bicyclic structure through the formation of a pair of disulfide bonds. The resulting bicyclic peptide has greatly enhanced proteolytic stability as well as cell-permeability...
February 1, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28034494/fighting-nemo-effect-of-17%C3%AE-ethinylestradiol-ee2-on-aggressive-behavior-and-social-hierarchy-of-the-false-clown-anemonefish-amphiprion-ocellaris
#12
Te-Hao Chen, Chun-Yu Hsieh
Aggressive behavior is crucial for maintaining social hierarchy in anemonefish. Endocrine disrupting chemicals such as EE2 may affect fish social hierarchy via disrupting their aggression. In this study, we aimed to characterize the effects of 17α-ethinylestradiol (EE2) on aggressive behavior and social hierarchy in the false clown anemonefish (Amphiprion ocellaris). In the laboratory experiment, juvenile anemonefish were randomly distributed to separated tanks to form small colonies of three individuals and were fed with EE2-dosed diet (100ng/g food) or a control diet for 90d...
December 26, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28011329/functional-role-of-ccl5-rantes-for-hcc-progression-during-chronic-liver-disease
#13
Antje Mohs, Nadine Kuttkat, Johanna Reißing, Henning Wolfgang Zimmermann, Roland Sonntag, Amanda Proudfoot, Sameh A Youssef, Alain de Bruin, Francisco Javier Cubero, Christian Trautwein
BACKGROUND & AIMS: During liver inflammation, triggering fibrogenesis and carcinogenesis immune cells play a pivotal role. In the present study we investigated the role of CCL5 in human and in murine models of chronic liver inflammation leading to HCC development. METHODS: CCL5 expression and its receptors were studied in well-defined patients with chronic liver disease (CLD) and in two murine inflammation based HCC models. The role of CCL5 in inflammation, fibrosis, tumor initiation and progression was analyzed in different cell populations of NEMO(Δhepa)/CCL5(-/-) animals and after bone marrow transplantation (BMT)...
December 20, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/28003306/microrna-221-enhances-mycn-via-targeting-nemo-like-kinase-and-functions-as-an-oncogene-related-to-poor-prognosis-in-neuroblastoma
#14
Xiao-Yan He, Zheng-Lan Tan, Qin Mou, Fang-Jie Liu, Shan Liu, Chao-Wen Yu, Jin Zhu, Lin-Ya Lv, Jun Zhang, Shan Wang, Liming Bao, Bin Peng, Hui Zhao, Lin Zou
PURPOSE: MYCN is one of the most well-characterized genetic markers of neuroblastoma (NB). However, the mechanisms as to how MYCN mediate NB tumorigenesis is not fully clear. Increasing evidence has confirmed that the dysregulation of miRNAs is involved in MYCN-mediated NB tumorigenesis, supporting their potential as therapeutic targets for NB. Though miR-221 has been reported as one of the upregulated miRNAs, the interplay between miR-221 and MYCN-mediated NB progression remains largely elusive...
December 21, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27984784/porcine-deltacoronavirus-nsp5-inhibits-interferon-%C3%AE-production-through-the-cleavage-of-nemo
#15
Xinyu Zhu, Liurong Fang, Dang Wang, Yuting Yang, Jiyao Chen, Xu Ye, Mohamed Frahat Foda, Shaobo Xiao
Porcine deltacoronavirus (PDCoV) causes acute enteric disease and mortality in seronegative neonatal piglets. Previously we have demonstrated that PDCoV infection suppresses the production of interferon-beta (IFN-β), while the detailed mechanisms are poorly understood. Here, we demonstrate that nonstructural protein 5 (nsp5) of PDCoV, the 3C-like protease, significantly inhibits Sendai virus (SEV)-induced IFN-β production by targeting the NF-κB essential modulator (NEMO), confirmed by the diminished function of NEMO cleaved by PDCoV...
February 2017: Virology
https://www.readbyqxmd.com/read/27979976/yap-needs-nemo-to-guide-a-hippo
#16
Alexander Hergovich
No abstract text is available yet for this article.
January 2017: EMBO Reports
https://www.readbyqxmd.com/read/27979972/phosphorylation-by-nlk-inhibits-yap-14-3-3-interactions-and-induces-its-nuclear-localization
#17
Sungho Moon, Wantae Kim, Soyoung Kim, Youngeun Kim, Yonghee Song, Oleksii Bilousov, Jiyoung Kim, Taebok Lee, Boksik Cha, Minseong Kim, Hanjun Kim, Vladimir L Katanaev, Eek-Hoon Jho
Hippo signaling controls organ size by regulating cell proliferation and apoptosis. Yes-associated protein (YAP) is a key downstream effector of Hippo signaling, and LATS-mediated phosphorylation of YAP at Ser127 inhibits its nuclear localization and transcriptional activity. Here, we report that Nemo-like kinase (NLK) phosphorylates YAP at Ser128 both in vitro and in vivo, which blocks interaction with 14-3-3 and enhances its nuclear localization. Depletion of NLK increases YAP phosphorylation at Ser127 and reduces YAP-mediated reporter activity...
January 2017: EMBO Reports
https://www.readbyqxmd.com/read/27975995/preliminary-results-on-basil-grown-in-the-nemo-s-garden%C3%A2
#18
L Pistelli, G Flamini, R Ascrizzi, L Pistelli, C Giuliani, C Cervelli, B Ruffoni, E Princi, S Gamberini, L Gamberini, G Fontanesi
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27956761/nemo-binding-domain-peptide-attenuates-lipopolysaccharide-induced-acute-lung-injury-by-inhibiting-the-nf-%C3%AE%C2%BAb-signaling-pathway
#19
Jianhua Huang, Li Li, Weifeng Yuan, Linxin Zheng, Zhenhui Guo, Wenjie Huang
The aim of the present study is to investigate the protective effects and relevant mechanisms exerted by NEMO-binding domain peptide (NBD) against lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice. The ALI model was induced by intratracheally administered atomized LPS (5 mg/kg) to BABL/c mice. Half an hour before LPS administration, we treated the mice with increasing concentrations of intratracheally administered NBD or saline aerosol. Two hours after LPS administration, each group of mice was sacrificed...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27956705/arfgap-domain-containing-protein-2-adap2-integrates-upstream-and-downstream-modules-of-rig-i-signaling-and-facilitates-type-i-interferon-production
#20
Pradeep Bist, Soo Yeon Kim, Niyas Kudukil Pulloor, Kathleen McCaffrey, Sajith Kumar Nair, Yiliu Liu, Rongtuan Lin, Manoj N Krishnan
: Transcription of Type I interferon during RNA virus infection requires signal communication between several Pattern recognition receptor (PRR)-adaptor complexes located at distinct subcellular membranous compartments and a central cytoplasmic TBK1-IRF3 kinase-transcription factor module. However, how cell integrates signal transduction through spatially distinct modules of antiviral signaling pathways is less defined. RIG-I is a major cytosolic PRR involved in the control of several RNA viruses...
December 12, 2016: Molecular and Cellular Biology
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