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Cardiovascular resonance

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https://www.readbyqxmd.com/read/28432753/identification-of-indothiazinone-as-a-natural-antiplatelet-agent
#1
Chansik Yang, Sugyeong Kwon, Se-Jong Kim, Minseon Jeong, Ji-Young Park, Dongeun Park, Soon Jun Hong, Jong-Wha Jung, Chungho Kim
Cardiovascular disease, which is caused by unregulated platelet aggregation, is one of the main causes of deaths worldwide. Many studies have focused on natural products with antiplatelet effects as a safe alternative therapy in order to prevent the disease. In this context, an in-house chemical library was screened to find natural products capable of inhibiting the interaction between platelet integrin αIIbβ3 and fibrinogen, which is an essential step in platelet aggregation. On the basis of the screening results, indothiazinone, an alkaloid found in microbial cultures, was identified as a potential antiplatelet agent...
April 22, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28431954/isolated-intracranial-fibromuscular-dysplasia-of-the-posterior-cerebral-artery
#2
Min-Ju Yeo, Ho-Yeong Jeon, Min-Ju Cha, Hye-Yeon Jang, Sang-Gil Lee, Ji Seon Kim, Sung-Hyun Lee, Sang-Soo Lee, Dong-Ick Shin
Fibromuscular dysplasia (FMD) is a nonatherosclerotic, noninflammatory arterial disease that most commonly affects the renal and internal carotid arteries, but intracranial FMD is very rare. We report a patient with FMD involving the posterior cerebral arteries (PCAs). A 24year old female was presented with a 4day history of right homonymous hemianopsia with throbbing headache in the left temporo-occipital area. The brain magnetic resonance imaging (MRI) revealed an acute ischemic stroke in the left PCA territory, while the Time of Flight (TOF) magnetic resonance angiogram (MRA) showed segmental luminal irregularities in the left proximal PCA...
April 18, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28430109/acquisition-of-electrocardiogram-signals-during-magnetic-resonance-imaging
#3
Julien Oster, Gari Clifford
The recording of the electrocardiogram (ECG) during Magnetic Resonance Imaging (MRI) acquisition is of great interest and importance. Firstly, MRI acquisition is a relatively slow process, which therefore complicates the imaging of moving organs. Cardiac MRI requires the development of strategies for acquiring high quality images, which is mainly achieved by synchronising the image acquisition with a specific time during the cardiac cycle. The ECG is used to monitor the heart's activity, and the detection of the largest and steepest peak in the cardiac cycle (the QRS complex) triggers the acquisition of slices of the k-space...
April 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28428195/progression-of-coronary-artery-calcium-and-incident-heart-failure-the-multi-ethnic-study-of-atherosclerosis
#4
Hooman Bakhshi, Bharath Ambale-Venkatesh, Xiaoying Yang, Mohammad R Ostovaneh, Colin O Wu, Matthew Budoff, Hossein Bahrami, Nathan D Wong, David A Bluemke, João A C Lima
BACKGROUND: Although the association between coronary artery calcium (CAC) and future heart failure (HF) has been shown previously, the value of CAC progression in the prediction of HF has not been investigated. In this study, we investigated the association of CAC progression with subclinical left ventricular (LV) dysfunction and incident HF in the Multi-Ethnic Study of Atherosclerosis. METHODS AND RESULTS: The Multi-Ethnic Study of Atherosclerosis is a population-based study consisting of 6814 men and women aged 45 to 84, free of overt cardiovascular disease at enrollment, who were recruited from 4 ethnicities...
April 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28426728/pulmonary-vascular-volume-impaired-left-ventricular-filling-and-dyspnea-the-mesa-lung-study
#5
Carrie P Aaron, Eric A Hoffman, Joao A C Lima, Steven M Kawut, Alain G Bertoni, Jens Vogel-Claussen, Mohammadali Habibi, Katja Hueper, David R Jacobs, Ravi Kalhan, Erin D Michos, Wendy S Post, Martin R Prince, Benjamin M Smith, Bharath Ambale-Venkatesh, Chia-Ying Liu, Filip Zemrak, Karol E Watson, Matthew Budoff, David A Bluemke, R Graham Barr
BACKGROUND: Evaluation of impaired left ventricular (LV) filling has focused on intrinsic causes of LV dysfunction; however, pulmonary vascular changes may contribute to reduced LV filling and dyspnea. We hypothesized that lower total pulmonary vascular volume (TPVV) on computed tomography (CT) would be associated with dyspnea and decrements in LV end-diastolic volume, particularly among ever-smokers. METHODS: The Multi-Ethnic Study of Atherosclerosis recruited adults without clinical cardiovascular disease in 2000-02...
2017: PloS One
https://www.readbyqxmd.com/read/28424090/targeted-endomyocardial-biopsy-guided-by-real-time-cardiovascular-magnetic-resonance
#6
Christina Unterberg-Buchwald, Christian Oliver Ritter, Verena Reupke, Robin Niklas Wilke, Christine Stadelmann, Michael Steinmetz, Andreas Schuster, Gerd Hasenfuß, Joachim Lotz, Martin Uecker
BACKGROUND: Endomyocardial biopsies (EMB) are an important diagnostic tool for myocarditis and other infiltrative cardiac diseases. Routinely, biopsies are obtained under fluoroscopic guidance with a substantial radiation burden. Despite procedural success, there is a large sampling error caused by missing the affected myocardium. Therefore, multiple (>6) biopsies are taken in the clinical setting. In cardiovascular magnetic resonance (CMR), late gadolinium enhancement (LGE) depicts areas of affected myocardium in myocarditis or in other infiltrative cardiomyopathies...
April 19, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28421174/utility-of-cardiovascular-magnetic-resonance-derived-wave-intensity-analysis-as-a-marker-of-ventricular-function-in-children-with-heart-failure-and-normal-ejection-fraction
#7
Hopewell N Ntsinjana, Robin Chung, Paolo Ciliberti, Vivek Muthurangu, Silvia Schievano, Jan Marek, Kim H Parker, Andrew M Taylor, Giovanni Biglino
OBJECTIVE: This study sought to explore the diagnostic insight of cardiovascular magnetic resonance (CMR)-derived wave intensity analysis to better study systolic dysfunction in young patients with chronic diastolic dysfunction and preserved ejection fraction (EF), comparing it against other echocardiographic and CMR parameters. BACKGROUND: Evaluating systolic and diastolic dysfunctions in children is challenging, and a gold standard method is currently lacking...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28420817/association-of-kidney-dysfunction-with-asymptomatic-cerebrovascular-abnormalities-in-a-japanese-population-with-health-checkups
#8
Kaori Hayashi, Michiyo Takayama, Takeshi Kanda, Kazuhiro Kashiwagi, Akihito Hishikawa, Yasushi Iwao, Hiroshi Itoh
BACKGROUND: Cerebrovascular disease is a major cause of mortality and morbidity. Chronic kidney disease (CKD) is prevalent in stroke patients. This study evaluated the correlation between kidney dysfunction and asymptomatic findings on carotid ultrasonography (US) and brain magnetic resonance imaging (MRI) in a Japanese population with health checkups.Methods and Results:In total, 1,716 subjects aged 40-80 years, who received health checkups from January 1 to December 31, 2015, were included...
April 14, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28420646/associations-between-left-ventricular-dysfunction-and-brain-structure-and-function-findings-from-the-sabre-southall-and-brent-revisited-study
#9
Chloe M Park, Emily D Williams, Nish Chaturvedi, Therese Tillin, Robert J Stewart, Marcus Richards, Dean Shibata, Jamil Mayet, Alun D Hughes
BACKGROUND: Subclinical left ventricular (LV) dysfunction has been inconsistently associated with early cognitive impairment, and mechanistic pathways have been poorly considered. We investigated the cross-sectional relationship between LV dysfunction and structural/functional measures of the brain and explored the role of potential mechanisms. METHOD AND RESULTS: A total of 1338 individuals (69±6 years) from the Southall and Brent Revisited study underwent echocardiography for systolic (tissue Doppler imaging peak systolic wave) and diastolic (left atrial diameter) assessment...
April 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28419023/interrelations-of-epicardial-fat-volume-left-ventricular-t1-relaxation-times-and-myocardial-strain-in-hypertensive-patients-a-cardiac-magnetic-resonance-study
#10
Rami Homsi, Daniel Kuetting, Alois Sprinkart, Nina Steinfeld, Michael Meier-Schroers, Julian Luetkens, Jennifer Nadal, Darius Dabir, Stefan Fischer, Juergen Gieseke, Hans Schild, Daniel Thomas
PURPOSE: This cardiac magnetic resonance study was performed to assess myocardial fibrosis by evaluating T1-relaxation time (T1), to measure left ventricular (LV) strain, and to determine epicardial fat volume (EFV) in hypertensive patients with no history of cardiovascular (CV) events and to relate the results to the presence of coronary atherosclerotic artery disease (CAD) in these patients. MATERIALS AND METHODS: A total of 123 subjects were examined at 1.5 T...
May 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28418811/hypertrabeculated-left-ventricular-myocardium-in-relationship-to-myocardial-function-and-fibrosis-the-multi-ethnic-study-of-atherosclerosis
#11
Nadine Kawel-Boehm, Robyn L McClelland, Filip Zemrak, Gabriella Captur, W Gregory Hundley, Chia-Ying Liu, James C Moon, Steffen E Petersen, Bharath Ambale-Venkatesh, João A C Lima, David A Bluemke
Purpose To determine if excess greater left ventricle (LV) trabeculation is associated with decreased average regional myocardial function, diffuse fibrosis, or both. Materials and Methods This was a HIPAA-compliant institutional board approved multicenter study, and all participants provided written informed consent. Participants in the Multi-Ethnic Study of Atherosclerosis (MESA) underwent a comprehensive cardiac magnetic resonance (MR) examination. LV trabeculation was measured with the maximal apical fractal dimension (FD), which is a marker of endocardial complexity...
April 17, 2017: Radiology
https://www.readbyqxmd.com/read/28418031/serum-concentration-of-hdl-particles-predicts-mortality-in-acute-heart-failure-patients
#12
Ines Potočnjak, Vesna Degoricija, Matias Trbušić, Gudrun Pregartner, Andrea Berghold, Gunther Marsche, Saša Frank
Clinical studies have shown that assessing circulating concentrations of high-density lipoprotein (HDL) particles by nuclear magnetic resonance (NMR) spectroscopy is superior to HDL-cholesterol in predicting cardiovascular risk. We tested the hypothesis that circulating concentrations of HDL particles predict 3-month mortality of patients with acute heart failure (AHF). Out of 152 included patients, 52% were female, additionally the mean patient age was 75.2 ± 10.3 years, and three-month mortality was 27%...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28416981/relationship-between-right-and-left-ventricular-function-in-candidates-for-implantable-cardioverter-defibrillator-with-low-left-ventricular-ejection-fraction
#13
Laura Jimenez-Juan, Gauri R Karur, Kim A Connelly, Djeven Deva, Raymond T Yan, Rachel M Wald, Sheldon Singh, General Leung, Anastasia Oikonomou, Paul Dorian, Paul Angaran, Andrew T Yan
BACKGROUND: Indications for the primary prevention of sudden death using an implantable cardioverter defibrillator (ICD) are based predominantly on left ventricular ejection fraction (LVEF). However, right ventricular ejection fraction (RVEF) is also a known prognostic factor in a variety of structural heart diseases that predispose to sudden cardiac death. We sought to investigate the relationship between right and left ventricular parameters (function and volume) measured by cardiovascular magnetic resonance (CMR) among a broad spectrum of patients considered for an ICD...
April 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28415091/moderated-posters-new-advances-in-cardiovascular-magnetic-resonance
#14
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28412421/change-in-carotid-plaque-components-a-4-year-follow-up-study-with-serial-mr-imaging
#15
Laura Pletsch-Borba, Mariana Selwaness, Aad van der Lugt, Albert Hofman, Oscar H Franco, Meike W Vernooij
OBJECTIVES: The goal of this study was to determine how carotid plaque components (e.g., intraplaque hemorrhage [IPH], calcification, lipid core) change over time and which cardiovascular risk factors are associated with the development of each component. BACKGROUND: Carotid atherosclerotic plaque components are important markers of plaque vulnerability. How these components change and which factors lead to the development and changes in the components remain unclear...
April 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28412277/the-association-of-endothelial-function-and-tone-by-digital-arterial-tonometry-with-mri-left-ventricular-mass-in-african-americans-the-jackson-heart-study
#16
Avnish Tripathi, Emelia J Benjamin, Solomon K Musani, Naomi M Hamburg, Connie W Tsao, Arti Saraswat, Ramachandran S Vasan, Gary F Mitchell, Ervin R Fox
Peripheral vascular endothelial dysfunction assessed by digital peripheral arterial tonometry (PAT) has been associated with risk for adverse cardiovascular events. We examined the relations of peripheral microvascular dysfunction and left ventricular mass in a community-based cohort of African Americans. We examined participants of the Jackson Heart Study who had PAT and cardiac magnetic resonance imaging evaluations between 2007 and 2013. Consistent with pertinent literature, left ventricular mass index (LVMI) was adjusted for body size by indexing to height(2...
March 27, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28411261/feasibility-and-diagnostic-value-of-cardiovascular-magnetic-resonance-imaging-after-acute-ischemic-stroke-of-undetermined-origin
#17
Karl Georg Haeusler, Christian Wollboldt, Laura Zu Bentheim, Juliane Herm, Sebastian Jäger, Claudia Kunze, Holger-Carsten Eberle, Claudia Christina Deluigi, Oliver Bruder, Carolin Malsch, Peter U Heuschmann, Matthias Endres, Heinrich J Audebert, Andreas J Morguet, Christoph Jensen, Jochen B Fiebach
BACKGROUND AND PURPOSE: Etiology of acute ischemic stroke remains undetermined (cryptogenic) in about 25% of patients after state-of-the-art diagnostic work-up. METHODS: One-hundred and three patients with magnetic resonance imaging (MRI)-proven acute ischemic stroke of undetermined origin were prospectively enrolled and underwent 3-T cardiac MRI and magnetic resonance angiography of the aortic arch in addition to state-of-the-art diagnostic work-up, including transesophageal echocardiography (TEE)...
April 14, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28411075/effect-of-gender-and-adiposity-on-in%C3%A2-vivo-vascular-function-in-young-african-americans
#18
Namrata Dass, Sindhu Kilakkathi, Brittaney Obi, Andrea Moosreiner, Shanthi Krishnaswami, Michael E Widlansky, Srividya Kidambi
The relationship between obesity and high blood pressure is not as strong among African Americans (AA) as compared to Caucasians. We designed the current study to determine the effect of adiposity on vascular endothelial function (a harbinger of hypertension) among young healthy AA without additional cardiovascular disease risk factors. A total of 108 AA subjects (46 women) between the ages of 18 and 45 years were recruited. All the subjects were normotensive, nonsmokers, and normoglycemic. Anthropometric and cardiovascular disease risk factor measurements (lipid, insulin resistance, and inflammatory markers) were obtained...
March 14, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28409253/review-of-key-concepts-in-magnetic-resonance-physics
#19
REVIEW
Michael M Moore, Taylor Chung
MR physics can be a challenging subject for practicing pediatric radiologists. Although many excellent texts provide very comprehensive reviews of the field of MR physics at various levels of understanding, the authors of this paper explain several key concepts in MR physics that are germane to clinical practice in a non-rigorous but practical fashion. With the basic understanding of these key concepts, practicing pediatric radiologists can build on their knowledge of current clinical MR techniques and future advances in MR applications...
May 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28408373/association-of-air-pollution-exposures-with-high-density-lipoprotein-cholesterol-and-particle-number-the-multi-ethnic-study-of-atherosclerosis
#20
Griffith Bell, Samia Mora, Philip Greenland, Michael Tsai, Ed Gill, Joel D Kaufman
OBJECTIVE: The relationship between air pollution and cardiovascular disease may be explained by changes in high-density lipoprotein (HDL). APPROACH AND RESULTS: We examined the cross-sectional relationship between air pollution and both HDL cholesterol and HDL particle number in the MESA Air study (Multi-Ethnic Study of Atherosclerosis Air Pollution). Study participants were 6654 white, black, Hispanic, and Chinese men and women aged 45 to 84 years. We estimated individual residential ambient fine particulate pollution exposure (PM2...
April 13, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
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