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Longitudinal function

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https://www.readbyqxmd.com/read/28227706/skin-mounted-accelerometer-system-for-measuring-knee-range-of-motion
#1
Ryan S McGinnis, Shyamal Patel, Ikaro Silva, Nikhil Mahadevan, Steve DiCristofaro, Elise Jortberg, Melissa Ceruolo, A J Aranyosi, Ryan S McGinnis, Shyamal Patel, Ikaro Silva, Nikhil Mahadevan, Steve DiCristofaro, Elise Jortberg, Melissa Ceruolo, A J Aranyosi, A J Aranyosi, Melissa Ceruolo, Ikaro Silva, Steve DiCristofaro, Elise Jortberg, Ryan S McGinnis, Shyamal Patel, Nikhil Mahadevan
Sufficient range of motion of the knee joint is necessary for performing many activities of daily living. Ambulatory monitoring of knee function can provide valuable information about progression of diseases like knee osteoarthritis and recovery after surgical interventions like total knee arthroplasty. In this paper, we describe a skin-mounted, conformal, accelerometer-based system for measuring knee angle and range of motion that does not require a skilled operator to apply devices. We establish the accuracy of this technique with respect to clinical gold standard goniometric measurements on a dataset collected from normative subjects during the performance of repeated bouts of knee flexion and extension tests...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227412/development-of-a-real-time-lumbar-ultrasound-image-processing-system-for-epidural-needle-entry-site-localization
#2
Yusong Leng, Shuang Yu, Kok Kiong Tan, Philip Tildsley, Alex Tiong Heng Sia, Ban Leong Sng, Yusong Leng, Shuang Yu, Kok Kiong Tan, Philip Tildsley, Alex Tiong Heng Sia, Ban Leong Sng, Yusong Leng, Shuang Yu, Philip Tildsley, Ban Leong Sng, Kok Kiong Tan
A fully-automatic ultrasound image processing system that can determine the needle entry site for epidural anesthesia (EA) in real time is presented in this paper. Neither the knowledge of anesthetists nor additional hardware is required to operate the system, which firstly directs the anesthetists to reach the desired insertion region in the longitudinal view, i.e., lumbar level L3-L4, and then locates the ideal puncture site by instructing the anesthetists to rotate and slightly adjust the position of ultrasound probe...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227395/impaired-episodic-memory-network-in-subjects-at-high-risk-for-alzheimer-s-disease
#3
Yafeng Zhan, Jianhua Ma, Kaibin Xu, Yanhui Ding, Yue Cui, Zhengyi Yang, Yong Liu, Yafeng Zhan, Jianhua Ma, Kaibin Xu, Yanhui Ding, Yue Cui, Zhengyi Yang, Yong Liu, Yanhui Ding, Kaibin Xu, Yue Cui, Yafeng Zhan, Jianhua Ma, Zhengyi Yang, Yong Liu
Episodic memory dysfunction is one of the hallmark symptoms of Alzheimer's disease (AD) and mild cognitive impairment (MCI). This cognitive impairment may be related to abnormal brain structure and activity. Functional connectivity mapping (FCM) analysis provides a powerful tool for exploring the topology of human brain function using magnetic resonance imaging (MRI). Thus, it would be advantageous to investigate the changes in functional connectivity within the episodic memory network in a longitudinal MCI dataset, as it may be helpful in identifying a potential marker of disease progress...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226582/towards-holistic-free-living-assessment-in-parkinson-s-disease-unification-of-gait-and-fall-algorithms-with-a-single-accelerometer
#4
Alan Godfrey, Alan Bourke, Silvia Del Din, Rosie Morris, Aodhan Hickey, Jorunn L Helbostad, Lynn Rochester, Alan Godfrey, Alan Bourke, Silvia Del Din, Rosie Morris, Aodhan Hickey, Jorunn L Helbostad, Lynn Rochester, Silvia Del Din, Rosie Morris, Alan Godfrey, Lynn Rochester, Jorunn L Helbostad, Aodhan Hickey, Alan Bourke
Technological developments have seen the miniaturization of sensors, small enough to be embedded in wearable devices facilitating unobtrusive and longitudinal monitoring in free-living environments. Concurrently, the advances in algorithms have been ad-hoc and fragmented. To advance the mainstream use of wearable technology and improved functionality of algorithms all methodologies must be unified and robustly tested within controlled and free-living conditions. Here we present and unify a (i) gait segmentation and analysis algorithm and (ii) a fall detection algorithm...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226317/neuroprotective-effects-of-acetyl-l-carnitine-on-neonatal-hypoxia-ischemia-induced-brain-injury-in-rats
#5
Shiyu Tang, Su Xu, Xin Lu, Rao P Gullapalli, Mary C McKenna, Jaylyn Waddell
Perinatal hypoxia ischemia (HI) is a significant cause of brain injury in surviving infants. Although hypothermia improves outcomes in some infants, additional therapies are needed since about 40% of infants still have a poor outcome. Acetyl-L-carnitine (ALCAR), an acetylated derivative of L-carnitine, protected against early changes in brain metabolites and mitochondrial function after HI on postnatal day (PND) 7 in a rat pup model of near-term HI injury. However, its efficacy in long-term structural and functional outcomes remains unexplored...
February 23, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28226275/short-term-cerebral-activity-alterations-after-surgery-in-patients-with-unilateral-mesial-temporal-lobe-epilepsy-associated-with-hippocampal-sclerosis-a-longitudinal-resting-state-fmri-study
#6
Yingying Tang, Wei Xia, Xiaofeng Yu, Bo Zhou, Chunyan Luo, Xiaoqi Huang, Qin Chen, Qiyong Gong, Dong Zhou
PURPOSE: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), as a brain network disorder, has given increased importance to resective surgery. We aimed to examine the short-term postoperative functional network reorganization in patients with unilateral MTLE-HS using resting-state functional magnetic resonance imaging (Rs-fMRI) data with a longitudinal design. METHOD: Seventeen (10 right-side and 7 left-side) patients with unilateral MTLE-HS were recruited...
January 3, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28225854/analysis-of-risk-prediction-capability-and-validity-of-morse-fall-scale-brazilian-version
#7
Janete de Souza Urbanetto, Thiana Sebben Pasa, Hélio Radke Bittencout, Flavia Franz, Vitor Pena Prazido Rosa, Tânia Solange Bosi de Souza Magnago
Objective: To analyse the power to predict risk and verify the validity of the Morse Fall Scale - Brazilian version (MFS-B). Method: This is a methodological, longitudinal study with 1487 adult patients of two university hospitals of Rio Grande do Sul, Brazil conducted from November 2013 to March 2014. The MFS-B was used to assess the risk of falls. Statistical analysis comprised multivariate methods (discriminant function analysis and ROC curve). The research was approved by the ethics committees of the institutions...
February 16, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28225543/cuba-s-aging-and-alzheimer-longitudinal-study
#8
Juan de Jesús Llibre-Rodríguez, Adolfo Valhuerdi-Cepero, Ana M López-Medina, Lisseth Noriega-Fernández, Rutbeskia Porto-Álvarez, Milagros A Guerra-Hernández, Rodolfo I Bosch-Bayard, Tania Zayas-Llerena, Elaine Hernandez-Ulloa, Ana L Rodríguez-Blanco, Enrique Salazar-Pérez, Juan C Llibre-Guerra, Jorge J Llibre-Guerra, Beatriz Marcheco-Teruel
Aging and Alzheimer is a prospective, longitudinal cohort study involving 2944 adults aged ≥65 years from selected areas in Cuba's Havana and Matanzas Provinces. This door-to-door study, which began in 2003, includes periodic assessments of the cohort based on an interview; physical exam; anthropometric measurements; and diagnosis of dementia and its subtypes, other mental disorders, and other chronic non-communicable diseases and their risk factors. Information was gathered on sociodemographic characteristics; disability, dependency and frailty; use of health services; and characteristics of care and caregiver burden...
January 2017: MEDICC Review
https://www.readbyqxmd.com/read/28224079/altered-structural-brain-changes-and-neurocognitive-performance-in-pediatric-hiv
#9
Santosh K Yadav, Rakesh K Gupta, Ravindra K Garg, Vimala Venkatesh, Pradeep K Gupta, Alok K Singh, Sheema Hashem, Asma Al-Sulaiti, Deepak Kaura, Ena Wang, Francesco M Marincola, Mohammad Haris
Pediatric HIV patients often suffer with neurodevelopmental delay and subsequently cognitive impairment. While tissue injury in cortical and subcortical regions in the brain of adult HIV patients has been well reported there is sparse knowledge about these changes in perinatally HIV infected pediatric patients. We analyzed cortical thickness, subcortical volume, structural connectivity, and neurocognitive functions in pediatric HIV patients and compared with those of pediatric healthy controls. With informed consent, 34 perinatally infected pediatric HIV patients and 32 age and gender matched pediatric healthy controls underwent neurocognitive assessment and brain magnetic resonance imaging (MRI) on a 3 T clinical scanner...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28223791/impact-of-exacerbations-on-respiratory-system-impedance-measured-by-a-forced-oscillation-technique-in-copd-a-prospective-observational-study
#10
Takahiro Kamada, Masahiro Kaneko, Hiromi Tomioka
BACKGROUND: Forced oscillation technique (FOT) has been reported to be useful in the evaluation and management of obstructive lung disease, including COPD. To date, no data are available concerning long-term changes in respiratory system impedance measured by FOT. Additionally, although exacerbations have been reported to be associated with excessive lung function decline in COPD, the impact of exacerbations on the results of FOT has not been demonstrated. The aim of this study was to investigate the longitudinal changes in respiratory system impedance and the influence of exacerbations thereon...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28223263/apps-for-people-with-rheumatoid-arthritis-to-monitor-their-disease-activity-a-review-of-apps-for-best-practice-and-quality
#11
Rebecca Grainger, Hermaleigh Townsley, Bonnie White, Tobias Langlotz, William J Taylor
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory arthritis requiring long-term treatment with regular monitoring by a rheumatologist to achieve good health outcomes. Since people with RA may wish to monitor their own disease activity with a smartphone app, it is important to understand the functions and quality of apps for this purpose. OBJECTIVE: The aim of our study was to assess the features and quality of apps to assist people to monitor their RA disease activity by (1) summarizing the available apps, particularly the instruments used for measurement of RA disease activity; (2) comparing the app features with American College of Rheumatology and European League against Rheumatism (ACR and EULAR) guidelines for monitoring of RA disease activity; and (3) rating app quality with the Mobile App Rating Scale (MARS)...
February 21, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28223129/regenerative-medicine-in-huntington-s-disease-strengths-and-weaknesses-of-preclinical-studies
#12
REVIEW
A M Tartaglione, P Popoli, G Calamandrei
TARTAGLIONE, A.M., P. Popoli and G. Calamandrei. Regenerative medicine in Huntington's disease: strengths and weaknesses of pre-clinical studies. NEUROSCIENCE BIOBEHAV REV (2016). Huntington's disease (HD) is an inherited neurodegenerative disorder, characterized by impairment in motor, cognitive and psychiatric domains. Currently, there is no specific therapy to act on the onset or progression of HD. The marked neuronal death observed in HD is a main argument in favour of stem cells (SCs) transplantation as a promising therapeutic perspective to replace the population of lost neurons and restore the functionality of the damaged circuitry...
February 18, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28222921/relationships-between-left-ventricular-structure-and-function-according-to-cardiac-mri-and-cardiac-biomarkers-in-end-stage-renal-disease
#13
Bryan A Ross, Ron Wald, Marc B Goldstein, Darren A Yuen, Jonathon Leipsic, Mercedeh Kiaii, Andrea Rathe, Djeven P Deva, Anish Kirpalani, Olugbenga O Bello, John J Graham, Howard Leong-Poi, Kim A Connelly, Andrew T Yan
BACKGROUND: We sought to assess the relationships between left ventricular (LV) remodelling and the mechanical and uremic stressors in hemodialysis patients. METHODS: In this prospective 2-centre cohort study, 67 prevalent hemodialysis patients were followed for 1 year. Data on routine bloodwork and predialysis blood pressure (BP) measurements were collected over a 12-week period. LV end-diastolic volume (LVEDV) and LV mass (LVM) were measured using cardiac magnetic resonance imaging and indexed...
December 3, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28222894/the-relationship-between-left-ventricular-deformation-and-heart-rate-variability-in-patients-with-systemic-sclerosis-two-and-three-dimensional-strain-analysis
#14
Marijana Tadic, Maja Zlatanovic, Cesare Cuspidi, Branislava Ivanovic, Ana Stevanovic, Nemanja Damjanov, Vesna Kocijancic, Vera Celic
OBJECTIVE: We sought to investigate left ventricular (LV) function and deformation, as well as heart rate variability (HRV), and their relationship, in patients with systemic sclerosis (SSc). METHODS: The study included 49 SSc patients and 38 age-matched healthy subjects. All patients underwent clinical examination, serological tests, 24-h Holter monitoring, and comprehensive two- and three-dimensional echocardiography (2DE and 3DE). RESULTS: 2DE and 3DE LV global longitudinal and circumferential strain, as well as 3DE area strains are significantly reduced in SSc patients comparing with controls...
February 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28222756/proximal-aortic-stiffening-in-turner-patients-may-be-present-before-dilation-can-be-detected-a-segmental-functional-mri-study
#15
Daniel G H Devos, Katya De Groote, Danilo Babin, Laurent Demulier, Yves Taeymans, Jos J Westenberg, Luc Van Bortel, Patrick Segers, Eric Achten, Jean De Schepper, Ernst Rietzschel
BACKGROUND: To study segmental structural and functional aortic properties in Turner syndrome (TS) patients. Aortic abnormalities contribute to increased morbidity and mortality of women with Turner syndrome. Cardiovascular magnetic resonance (CMR) allows segmental study of aortic elastic properties. METHOD: We performed Pulse Wave Velocity (PWV) and distensibility measurements using CMR of the thoracic and abdominal aorta in 55 TS-patients, aged 13-59y, and in a control population (n = 38;12-58y)...
February 13, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28222119/revised-hammersmith-scale-for-spinal-muscular-atrophy-a-sma-specific-clinical-outcome-assessment-tool
#16
Danielle Ramsey, Mariacristina Scoto, Anna Mayhew, Marion Main, Elena S Mazzone, Jacqueline Montes, Roberto de Sanctis, Sally Dunaway Young, Rachel Salazar, Allan M Glanzman, Amy Pasternak, Janet Quigley, Elizabeth Mirek, Tina Duong, Richard Gee, Matthew Civitello, Gihan Tennekoon, Marika Pane, Maria Carmela Pera, Kate Bushby, John Day, Basil T Darras, Darryl De Vivo, Richard Finkel, Eugenio Mercuri, Francesco Muntoni
Recent translational research developments in Spinal Muscular Atrophy (SMA), outcome measure design and demands from regulatory authorities require that clinical outcome assessments are 'fit for purpose'. An international collaboration (SMA REACH UK, Italian SMA Network and PNCRN USA) undertook an iterative process to address discontinuity in the recorded performance of the Hammersmith Functional Motor Scale Expanded and developed a revised functional scale using Rasch analysis, traditional psychometric techniques and the application of clinical sensibility via expert panels...
2017: PloS One
https://www.readbyqxmd.com/read/28221807/mechanostereoselective-one-pot-synthesis-of-functionalized-head-to-head-cyclodextrin-3-rotaxanes-and-their-application-as-magnetic-resonance-imaging-contrast-agents
#17
Jean Wilfried Fredy, Jérémy Scelle, Gregory Ramniceanu, Bich-Thuy Doan, Célia S Bonnet, Éva Tóth, Mickaël Ménand, Matthieu Sollogoub, Guillaume Vives, Bernold Hasenknopf
A versatile, five-component, one-pot synthesis of cyclodextrin (CD) [3]rotaxanes using copper-catalyzed azide-alkyne cycloaddition has been developed. Head-to-head [3]rotaxanes of α-CD selectively functionalized by one or two gadolinium 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid monoamide complexes were obtained mechanostereoselectively. The magnetic resonance imaging efficiency, expressed by the longitudinal proton relaxivity of the rotaxanes, was significantly improved as compared to the functionalized CD...
February 21, 2017: Organic Letters
https://www.readbyqxmd.com/read/28221285/genome-wide-methylation-analysis-of-a-large-population-sample-shows-neurological-pathways-involvement-in-chronic-widespread-musculoskeletal-pain-cwp
#18
Gregory Livshits, Ida Malkin, Maxim B Freidin, Yudong Xia, Fei Gao, Jun Wang, Timothy D Spector, Alex MacGregor, Jordana T Bell, Frances Mk Williams
Chronic widespread musculoskeletal pain (CWP), has a considerable heritable component, which remains to be explained. Epigenetic factors may contribute to and account for some of the heritability estimate. We analysed epigenome-wide methylation using MeDIPseq in whole blood DNA from 1708 monozygotic (MZ) and dizygotic (DZ) Caucasian twins having CWP prevalence of 19.9%. Longitudinally stable methylation bins (lsBINs), were established by testing repeated measurements conducted ≥3 years apart, n=292. DNA methylation variation at lsBINs was tested for association with CWP in a discovery set of 50 MZ twin pairs discordant for CWP, and in an independent dataset (n=1608 twins), and the results from the two samples were combined using Fisher's method...
February 15, 2017: Pain
https://www.readbyqxmd.com/read/28221284/pain-interference-and-physical-function-demonstrate-poor-longitudinal-association-in-people-living-with-pain-a-promis-investigation
#19
Nicholas V Karayannis, John A Sturgeon, Ming Chih-Kao, Corinne Cooley, Sean C Mackey
A primary goal in managing pain is to reduce pain and increase physical function (PF). This goal is also tied to continuing payment for treatment services in many practice guidelines. Pain interference (PI) is often used as a proxy for measurement and reporting of PF in these guidelines. A common assumption is that reductions in PI will translate into improvement in PF over time. This assumption needs to be tested in a clinical environment. Consequently, we used the patient reported outcomes measurement information system (PROMIS) to describe the topology of the longitudinal relationship between PI in relation to PF...
February 16, 2017: Pain
https://www.readbyqxmd.com/read/28220654/longitudinal-study-examining-abnormal-white-matter-integrity-using-a-tract-specific-analysis-in-individuals-with-a-high-risk-for-psychosis
#20
Junichi Saito, Masaaki Hori, Takahiro Nemoto, Naoyuki Katagiri, Keigo Shimoji, Shinya Ito, Naohisa Tsujino, Taiju Yamaguchi, Nobuyuki Shiraga, Shigeki Aoki, Masafumi Mizuno
AIM: Although volume reductions in the grey matter have been previously observed in individuals with an at-risk mental state (ARMS) for psychosis, the features of white matter integrity and their correlation with psychiatric symptoms remain unclear. METHODS: Forty-six ARMS subjects were examined using magnetic resonance imaging (MRI) to acquire diffusion tensor imaging (DTI) images; the subjects were also evaluated using the Scale of Prodromal Symptoms at baseline and at 52 weeks...
February 20, 2017: Psychiatry and Clinical Neurosciences
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