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Longitudinal function

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https://www.readbyqxmd.com/read/28644707/relationship-between-neurocognitive-function-and-clinical-symptoms-with-self-stigma-in-patients-with-schizophrenia-spectrum-disorders
#1
Sherry Kit Wa Chan, Shiao Yan Sharon Kao, Shing Lam Leung, Christy Lai Ming Hui, Edwin Ho Ming Lee, Wing Chung Chang, Eric Yu Hai Chen
BACKGROUND: Self-stigma is associated with poor outcomes of patients with schizophrenia and development of self-stigma is a complex process. Results of studies on relationship of both positive and negative symptoms of psychosis with self-stigma have been inconsistent. Cognitive deficits are common to patients. However, number of studies exploring the relationship specifically between self-stigma and neurocognition are limited. AIMS: The current study aimed to examine the relationship between neurocognitive functions and clinical symptoms with self-stigma...
June 23, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28644705/narrative-development-and-supported-employment-of-persons-with-severe-mental-illness
#2
Kelly Ann Cartwright, Tania Lecomte, Marc Corbière, Paul Lysaker
BACKGROUND: While the relationship between objective recovery and work among persons with severe mental illness (SMI) is well-established, few studies have examined the link between subjective recovery and employment. AIMS: The study investigated the prospective relationship between narrative development at the start of supported employment (SE) and positive work outcomes. METHODS: The authors employed a time-limited, mixed-method longitudinal design to examine the relationship between the baseline narrative development of 38 SE participants with SMI and employment outcomes eight months later, as well as whether narratives evolved over the course of the study...
June 23, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28644677/young-athletes-after-anterior-cruciate-ligament-reconstruction-with-single-leg-landing-asymmetries-at-the-time-of-return-to-sport-demonstrate-decreased-knee-function-2-years-later
#3
Matthew P Ithurburn, Mark V Paterno, Kevin R Ford, Timothy E Hewett, Laura C Schmitt
BACKGROUND: Previous work shows that young athletes after anterior cruciate ligament reconstruction (ACLR) demonstrate single-leg (SL) landing movement asymmetries at the time of return to sport (RTS); however, the effect of movement asymmetries on longitudinal knee-related function after ACLR has not been examined. Hypothesis/Purpose: The purpose of this study was to examine the effect of SL drop-landing movement symmetry at the time of RTS on knee-related function 2 years later in young athletes after ACLR...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28643694/simultaneous-maximum-a-i-posteriori-i-longitudinal-pet-image-reconstruction
#4
Sam Ellis, Andrew J Reader
Positron emission tomography (PET) is frequently used to monitor functional changes that occur over extended time scales, for example in longitudinal oncology PET protocols that include routine clinical follow-up scans to assess the efficacy of a course of treatment. In these contexts PET datasets are currently reconstructed into images using single-dataset reconstruction methods. Inspired by recently proposed joint PET-MR reconstruction methods, we propose to reconstruct longitudinal datasets simultaneously by using a joint penalty term in order to exploit the high degree of similarity between longitudinal images...
June 23, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28643350/habitual-sleep-and-kidney-function-in-chronic-kidney-disease-the-chronic-renal-insufficiency-cohort-study
#5
Kristen L Knutson, James Lash, Ana C Ricardo, James Herdegen, J D Thornton, Mahboob Rahman, Nicolas Turek, Janet Cohan, Lawrence J Appel, Lydia A Bazzano, Manjula K Tamura, Susan P Steigerwalt, Matthew R Weir, Eve Van Cauter
Physiological evidence suggests that sleep modulates kidney function. Our objective was to examine the cross-sectional association between kidney function and objectively-estimated habitual sleep duration, quality and timing in a cohort of patients with mild to moderate chronic kidney disease. This study involved two US clinical centers of the Chronic Renal Insufficiency Cohort (CRIC) study, including 432 participants in a CRIC ancillary sleep study. Habitual sleep duration, quality and timing were measured using wrist actigraphy for 5-7 days...
June 23, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28643068/effects-of-barbed-suture-during-robot-assisted-radical-prostatectomy-on-postoperative-tissue-damage-and-longitudinal-changes-in-lower-urinary-tract-outcome
#6
Nobuhiro Haga, Noriaki Kurita, Tomohiko Yanagida, Soichiro Ogawa, Michihiro Yabe, Hidenori Akaihata, Junya Hata, Yuichi Sato, Kei Ishibashi, Osamu Hasegawa, Yoshiyuki Kojima
OBJECTIVE: To compare the postoperative tissue damage and longitudinal changes in functional and patient-reported outcomes after vesicourethral anastomosis with barbed suture and nonbarbed suture in robot-assisted laparoscopic radical prostatectomy (RARP). MATERIALS AND METHODS: This was a prospective cohort study involving 88 consecutive patients who underwent RARP. These patients were categorized into the barbed suture group (n = 50) and the nonbarbed suture group (n = 38)...
June 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28642993/impact-of-left-ventricular-longitudinal-functional-mechanics-on-the-progression-of-diastolic-function-in-diabetes-mellitus
#7
Yasuhide Mochizuki, Hidekazu Tanaka, Kensuke Matsumoto, Hiroyuki Sano, Hiroyuki Shimoura, Junichi Ooka, Takuma Sawa, Yoshiki Motoji, Keiko Ryo-Koriyama, Yushi Hirota, Wataru Ogawa, Ken-Ichi Hirata
Left ventricular (LV) diastolic dysfunction and longitudinal systolic dysfunction were identified in patients with diabetes mellitus (DM). This study's aim was to investigate the impact of LV longitudinal systolic function on LV diastolic function in DM patients with preserved LV ejection fraction (LVEF). We studied 177 DM patients with preserved LVEF (all ≥50%), and 82 age-, gender- and LVEF-matched healthy volunteers as control. Global longitudinal strain (GLS) was defined as the average peak strain of 18 segments from standard apical views, GLS <18% as subclinical LV systolic dysfunction (LVSD), and LV dispersion as the standard deviation of time-to-peak strain from the same views...
June 22, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28642124/identification-of-genetic-variants-associated-with-huntington-s-disease-progression-a-genome-wide-association-study
#8
Davina J Hensman Moss, Antonio F Pardiñas, Douglas Langbehn, Kitty Lo, Blair R Leavitt, Raymund Roos, Alexandra Durr, Simon Mead, Peter Holmans, Lesley Jones, Sarah J Tabrizi
BACKGROUND: Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. METHODS: We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008-11)...
June 19, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28641996/impact-of-paliperidone-palmitate-versus-oral-atypical-antipsychotics-on-health-care-resource-use-and-costs-in-veterans-with-schizophrenia-and-comorbid-substance-abuse
#9
Patrick Lefebvre, Erik Muser, Kruti Joshi, Maral DerSarkissian, Rachel H Bhak, Mei Sheng Duh, Brian Shiner, Yinong Young-Xu
PURPOSE: Almost half of all patients diagnosed with schizophrenia have a history of substance abuse (SA). However, data on treatment of schizophrenia with paliperidone palmitate (PP) among patients with comorbid SA are limited. The objective of this study was to compare all-cause and SA-related health care resource utilization and costs in veterans with schizophrenia and co-occurring SA who were treated with PP versus oral atypical antipsychotics (OAAs). METHODS: Veterans Health Administration electronic health record data were used to conduct a retrospective longitudinal study in veterans with schizophrenia who initiated PP or OAA between January 1, 2010 and June 30, 2016, had ≥12 months of enrollment before treatment initiation (baseline), were diagnosed with SA, and had ≥1 Global Assessment of Functioning score during baseline...
June 19, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28641769/reduction-of-pk11195-uptake-observed-in-multiple-sclerosis-lesions-after-natalizumab-initiation
#10
Ulrike W Kaunzner, Yeona Kang, Elizabeth Monohan, Paresh J Kothari, Nancy Nealon, Jai Perumal, Timothy Vartanian, Amy Kuceyeski, Shankar Vallabhajosula, P David Mozley, Claire S Riley, Stephen M Newman, Susan A Gauthier
OBJECTIVE: The objective of this study is to longitudinally analyze the uptake of [(11)C]PK11195-PET in multiple sclerosis patients after 3 and 6 months of natalizumab treatment. METHODS: Eighteen MS patients, starting treatment with monocloncal anti-VLA-4, were enrolled in a longitudinal PK-PET study. PK uptake was quantified by volume of distribution (VT) calculation using image-derived input function at baseline, 3 and 6 months. Pharmacokinetic quantification was done using a segmented MRI, and selected areas included white matter, gadolinium enhancing lesions, non-enhancing lesions, cortical grey matter and thalamus...
July 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28641716/the-effects-of-pleural-plaques-on-longitudinal-lung-function-in-vermiculite-miners-of-libby-montana
#11
Kathleen A Clark, J Jay Flynn, Wilfried J J Karmaus, Lawrence C Mohr
BACKGROUND: This study was conducted to assess associations of pleural plaques (PP) and longitudinal lung function in vermiculite miners of Libby, Montana who are occupationally exposed to asbestos. High-resolution computed tomography (HRCT) was used to identify asbestos-related findings in former Libby vermiculite miners. We investigated annual lung function decline in miners with PP only and compared them to miners with normal HRCT findings. MATERIALS AND METHODS: HRCTs from 128 miners were categorized into the following 4 diagnostic groups: (1) normal computed tomography scan (n = 9); (2) PP only (n = 72); (3) PP and interstitial fibrosis (n = 26) and (4) additional HRCT abnormalities (n = 21) such as rounded atelectasis, diffuse pleural thickening, pleural effusions or pulmonary nodules or tumor >1cm in diameter...
June 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28641506/regulatory-forum-opinion-piece-imaging-applications-in-toxicologic-pathology-recommendations-for-use-in-regulated-nonclinical-toxicity-studies
#12
Robert R Maronpot, Abraham Nyska, Sean P Troth, Kathleen Gabrielson, Polina Sysa-Shah, Vyacheslav Kalchenko, Yuri Kuznetsov, Alon Harmelin, Yael S Schiffenbauer, David Bonnel, Jonathan Stauber, Yuval Ramot
Available imaging systems for use in preclinical toxicology studies increasingly show utility as important tools in the toxicologic pathologist's armamentarium, permit longitudinal evaluation of functional and morphological changes in tissues, and provide important information such as organ and lesion volume not obtained by conventional toxicology study parameters. Representative examples of practical imaging applications in toxicology research and preclinical studies are presented for ultrasound, positron emission tomography/single-photon emission computed tomography, optical, magnetic resonance imaging, and matrix-assisted laser desorption ionization-imaging mass spectrometry imaging...
June 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28641159/a-model-to-calculate-the-progression-of-the-centre-of-pressure-under-the-foot-during-gait-analysis
#13
Melissa Gar Yee Louey, Anita Mudge, Elizabeth Wojciechowski, Morgan Sangeux
Pedobarography and the centre of pressure (COP) progression is useful to understand foot function. Pedobarography is often unavailable in gait laboratories or completed asynchronously to kinematic and kinetic data collection. This paper presents a model that allows calculation of COP progression synchronously using force plate data. The model is an adjunct to Plug-In-Gait and was applied to 49 typically developing children to create reference COP data. COP progressions were noted to spend 8% of stance behind the ankle joint centre, traverse lateral of the longitudinal axis of the foot through the midfoot for 76% of stance and finishing past the second metatarsal head on the medial side for 16% of stance...
June 10, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28639946/assessment-of-left-ventricular-systolic-function-in-patients-with-iron-deficiency-anemia-by-three-dimensional-speckle-tracking-echocardiography
#14
Qiao Zhou, Jiaqi Shen, Yue Liu, Runlan Luo, Bijun Tan, Guangsen Li
OBJECTIVE: The present study aimed to evaluate left ventricular (LV) systolic function in patients with iron deficiency anemia (IDA) by 3 dimensional speckle-tracking echocardiography (3DSTE). METHODS: Participants were grouped by hemoglobin (Hb) levels in order to study the effect of anemia on cardiac function. Group A included 40 healthy volunteers. Eighty-three patients who were diagnosed with IDA were divided into 2 groups according to the Hb level. Group B (Hb 9 g/dL) included 44 patients, while group C (Hb 6-9 g/dL) included 39 patients...
June 22, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28639878/exploring-the-phenotype-in-mild-cognitive-impairment-to-aid-the-prediction-of-those-at-risk-of-transitioning-to-parkinson-disease-and-dementia-with-lewy-bodies
#15
Jennifer Y Y Szeto, Glenda M Halliday, Sharon L Naismith, Simon J G Lewis
To date, only limited research has concurrently investigated the presence of rapid eye movement sleep behavior disorder (RBD) and other features associated with Parkinson disease (PD) and dementia with Lewy bodies (DLB) in people presenting with mild cognitive impairment (MCI). As a first step towards a longitudinal research project, the present study explored the relationships between MCI, RBD, and depression in 108 older adults who presented with subjective memory complaints but were not known to have a neurodegenerative condition...
July 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28639877/mild-cognitive-impairment-and-changes-in-everyday-function-over-time-the-importance-of-evaluating-both-speed-and-accuracy
#16
Caroline L Lassen-Greene, Kayla Steward, Ozioma Okonkwo, Ellen Porter, Michael Crowe, David E Vance, H Randall Griffith, Karlene Ball, Daniel C Marson, Virginia G Wadley
OBJECTIVES: Research estimates that a significant percentage of individuals with mild cognitive impairment (MCI) experience functional difficulties. In addition to reduced accuracy on measures of everyday function, cross-sectional research has demonstrated that speed of performing instrumental activities of daily living (IADLs) is slowed in individuals with MCI. The present study investigated whether baseline and longitudinal changes in speed and accuracy of IADL performance differed between persons with MCI and cognitively normal peers...
July 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28639821/perceived-discrimination-associations-with-physical-and-cognitive-function-in-older-adults
#17
Aparna Shankar, Petra Hinds
OBJECTIVES: Perceived discrimination has been associated with poor physical and psychological health. There is limited research examining perceived discrimination in older adults, and its effects on health in later life. The aim of this study is to extend research in this area by examining longitudinal associations between reported everyday discrimination and physical and cognitive function in older adults. METHOD: The present study uses a national sample of 4,886 community-dwelling individuals aged 60 years and older from the English Longitudinal Study of Ageing...
June 22, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28639724/longitudinal-changes-in-global-and-domain-specific-cognitive-function-in-the-very-old-findings-from-the-newcastle-85-study
#18
Blossom C M Stephan, Graciela Muniz-Terrera, Antoneta Granic, Joanna Collerton, Karen Davies, Brian K Saxby, Keith A Wesnes, Thomas B L Kirkwood, Carol Jagger
OBJECTIVE: Ageing is associated with changes in cognition in some, but not all domains. In young-old adults, defined as persons aged 65-84 years, baseline cognitive function has been shown to impact on cognitive trajectories. Whether similar patterns occur in the very-old, defined as persons aged 85 years and over, is not known. METHODS: Longitudinal changes (5 years' follow-up) in global and domain specific cognitive function including memory, attention and speed were investigated in participants from the Newcastle 85+ Study (n = 845)...
June 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28639659/hydrothermal-and-biomineralization-synthesis-of-a-dual-modal-nanoprobe-for-targeted-near-infrared-persistent-luminescence-and-magnetic-resonance-imaging
#19
Yu Wang, Cheng-Xiong Yang, Xiu-Ping Yan
The development of the multimodal probes is of great importance for bioimaging application. Herein, we report the fabrication of a functional nanocomposite from near-infrared (NIR) persistent luminescent nanoparticles (PLNPs) and Gd2O3 as a multimodal probe for in vivo NIR persistent luminescence and magnetic resonance (MR) imaging. Small-sized monodispersed NIR ZnGa2O4:Cr(3+) PLNPs (ca. 15 nm) were prepared as the NIR persistent luminescence source by a hydrothermal method while hyaluronic acid (HA) functionalized Gd2O3 (HA-Gd2O3) was synthesized as the MR contrast agent via a biomineralization approach...
June 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28639427/resilience-dimensions-and-mental-health-outcomes-in-bipolar-disorder-in-a-follow-up-study
#20
A Echezarraga, E Calvete, A M González-Pinto, C Las Hayas
The individual process of resilience has been related to positive outcomes in mental disorders. We aimed (a) to identify the resilience domains from the Resilience Questionnaire for Bipolar Disorder that are associated cross sectionally and longitudinally with mental health outcomes in bipolar disorder (BD) and (b) to explore cross-lagged associations among resilience factors. A clinical adult sample of 125 patients diagnosed with BD (62.10% female, mean age = 46.13, SD = 10.89) gave their informed consent and completed a battery of disease-specific tools on resilience, personal recovery, symptomatology, psychosocial functioning, and quality of life, at baseline and at follow-up (n = 63, 58...
June 22, 2017: Stress and Health: Journal of the International Society for the Investigation of Stress
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