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https://www.readbyqxmd.com/read/28551797/peripheral-blood-mitochondrial-dna-and-myocardial-function
#1
Tatiana Kuznetsova, Judita Knez
Heart failure is a complex progressive clinical syndrome which is initiated by risk factors (e.g., hypertension, obesity, and diabetes), then proceeds to asymptomatic maladaptive left ventricular remodeling and dysfunction, and finally evolves into clinically overt, symptomatic heart failure, disability, and death. The progression of left ventricular dysfunction is associated with changes in cardiac energy metabolism. Mitochondria play a central role in a variety of cardiomyocytes functions, including oxidative energy production, storage of calcium ions, and programmed cell death...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551760/genetic-and-environmental-influences-on-longitudinal-trajectories-of-functional-biological-age-comparisons-across-gender
#2
Deborah Finkel, Ola Sternäng, Åke Wahlin
We used an alternate age variable, functional biological age (fBioAge), which was based on performance on functional body measures. The aim was to examine development of fBioAge across the adult life span, and to also examine potential gender differences and genetic and environmental influences on change with age. We used longitudinal data (n = 740; chronological age (ChronAge) range 45-85 at baseline) from the Swedish Adoption/Twin Study of Aging. The rate of increase in fBioAge was twice as fast after ChronAge 75 than before...
May 27, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28551466/stance-instability-in-preclinical-sca1-mutation-carriers-a-4-year-prospective-posturography-study
#3
Lorenzo Nanetti, Dario Alpini, Valentina Mattei, Anna Castaldo, Alessia Mongelli, Greta Brenna, Cinzia Gellera, Caterina Mariotti
OBJECTIVE: We aimed to study postural balance in preclinical Spinocerebellar ataxia type 1 (SCA1) mutation carriers to identify and observe specific motor functional deficit before evident clinical manifestation. METHODS: Participants were 9 asymptomatic SCA1 mutation carriers (6M/3F), aged 31.8±7years (range 22-44), and 17 age-matched non-carrier controls (5M/12F) (age 18-42). Subjects underwent postural tests on a force platform (Tetrax(®)-IBS, Sunlight Medical Ltd...
May 17, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28551353/the-role-of-interleukin-1%C3%AE-as-a-predictive-biomarker-and-potential-therapeutic-target-during-clinical-ex-vivo-lung-perfusion
#4
Anders S I Andreasson, Lee A Borthwick, Colin Gillespie, Kasim Jiwa, Jonathan Scott, Paul Henderson, Jonny Mayes, Rosalba Romano, Marius Roman, Simi Ali, James E Fildes, Nandor Marczin, John H Dark, Andrew J Fisher
BACKGROUND: Extended criteria donor lungs deemed unsuitable for immediate transplantation can be reconditioned using ex vivo lung perfusion (EVLP). Objective identification of which donor lungs can be successfully reconditioned and will function well post-operatively has not been established. This study assessed the predictive value of markers of inflammation and tissue injury in donor lungs undergoing EVLP as part of the DEVELOP-UK study. METHODS: Longitudinal samples of perfusate, bronchoalveolar lavage, and tissue from 42 human donor lungs undergoing clinical EVLP assessments were analyzed for markers of inflammation and tissue injury...
May 12, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28551092/speckle-tracking-echocardiography-and-tissue-doppler-imaging-reveal-beneficial-effect-of-pharmacotherapy-in-hypertensives-with-asymptomatic-left-ventricular-dysfunction
#5
Beata Uziębło-Życzkowska, Paweł Krzesiński, Grzegorz Gielerak, Andrzej Skrobowski
Global longitudinal strain (GLS), assessed by speckle tracking echocardiography, is a sensitive marker of myocardial systolic function and an independent predictor of cardiovascular outcomes. The aim of this study was to investigate the effect of hypotensive treatment on GLS and evaluate the relation between change in GLS and left ventricular (LV) diastolic function. In a group of 125 hypertensive subjects, without any symptoms of heart failure, the detailed echocardiographic assessment of LV systolic and diastolic function was performed before and after 12 months of hypotensive treatment...
May 8, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28550266/assessing-decline-visualising-progression-in-huntington-s-disease-using-a-clinical-dashboard-with-enroll-hd-data
#6
Thomas Walker, Boyd Ghosh, Christopher Kipps
BACKGROUND: In Huntington's disease (HD), it remains unclear how symptom severity and rate of symptomatic change relates to age and CAG repeat number (CAGn). It is often difficult for clinicians to assess whether an affected individual's symptoms are progressing at a similar rate to their affected peers, limiting their ability to intervene at the most appropriate time. OBJECTIVE: To develop a clinical dashboard that compares an individual's total motor score (TMS), total functional capacity (TFC) and symbol digit modality test (SDMT) scores against a global cohort, controlling for age and CAGn...
May 24, 2017: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/28550257/increasing-body-mass-index-at-midlife-is-associated-with-increased-cortical-thinning-in-alzheimer-s-disease-vulnerable-regions
#7
Marnie E Shaw, Walter P Abhayaratna, Kaarin J Anstey, Nicolas Cherbuin
Higher body mass index (BMI) at midlife is associated with greater decreases in cognitive function at older age as well as increased Alzheimer's disease (AD) risk, compared to those with normal BMI. Here, we tested whether BMI at midlife was associated with cortical thinning in brain regions known to be affected in early AD. We examined a large sample (n = 404) of midlife individuals (44-49 years) from the PATH population-based study. Individuals were scanned with magnetic resonance imaging (1.5T) on up to three occasions over eight years...
May 26, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28550022/longitudinal-assessment-of-brain-derived-neurotrophic-factor-in-sardinian-psychotic-patients-labsp-a-protocol-for-a-prospective-observational-study
#8
Diego Primavera, Mirko Manchia, Luca Deriu, Massimo Tusconi, Roberto Collu, Maria Scherma, Paola Fadda, Walter Fratta, Bernardo Carpiniello
INTRODUCTION: Brain-derived neurotrophic factor (BDNF) plays a crucial role in neurodevelopment, synaptic plasticity and neuronal function and survival. Serum and plasma BDNF levels are moderately, but consistently, decreased in patients with schizophrenia (SCZ) compared with healthy controls. There is a lack of knowledge, however, on the temporal manifestation of this decline. Clinical, illness course and treatment factors might influence the variation of BDNF serum levels in patients with psychosis...
May 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/28549797/cortico-amygdalar-maturational-coupling-is-associated-with-depressive-symptom-trajectories-during-adolescence
#9
Nandita Vijayakumar, Nicholas B Allen, Meg Dennison, Michelle L Byrne, Julian G Simmons, Sarah Whittle
BACKGROUND: Adolescence is characterized by increasing prevalence of depressive symptomatology, along with significant structural brain development. While much research has examined focal abnormalities in gray matter structure underlying depression, we employed a structural coupling approach to examine whether longitudinal associations between amygdala and cortical development (referred to as maturational coupling) was related to concurrent changes in depressive symptomatology during adolescence...
May 23, 2017: NeuroImage
https://www.readbyqxmd.com/read/28549270/the-effects-of-early-life-adversity-on-the-immune-system
#10
REVIEW
Martha M C Elwenspoek, Annette Kuehn, Claude P Muller, Jonathan D Turner
Early life adversity (ELA) is associated with a higher risk for diseases in adulthood. Although the pathophysiological effects of ELA are varied, there may be a unifying role for the immune system in all of the long-term pathologies such as chronic inflammatory disorders (autoimmune diseases, allergy, and asthma). Recently, significant efforts have been made to elucidate the long-term effects ELA has on immune function, as well as the mechanisms underlying these immune changes. In this review, we focus on data from human studies investigating immune parameters in relation to post-natal adverse experiences...
May 17, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28549180/relationships-among-self-perception-of-aging-physical-functioning-and-self-efficacy-in-late-life
#11
Hava Tovel, Sara Carmel, Victoria H Raveis
Objectives: The purpose of the current study was to examine the longitudinal relationship between 2 central concepts in the study of subjective well-being in old age-self-perception of aging (SPA) and physical functioning, and to assess the mediating role of self-efficacy beliefs in this relationship. Methods: Interviews were conducted in the home with 1,216 randomly selected persons aged 75+ years (T1) and repeated with 892 of them 2 years later (T2). We collected data on SPA, physical functioning, self-efficacy, self-rated health, and demographics...
May 25, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28549111/diabetic-db-db-mice-do-not-develop-heart-failure-upon-pressure-overload-a-longitudinal-in-vivo-pet-mri-and-mrs-study-on-cardiac-metabolic-structural-and-functional-adaptations
#12
Desiree Abdurrachim, Miranda Nabben, Verena Hoerr, Michael T Kuhlmann, Philipp Bovenkamp, Jolita Ciapaite, Ilvy M E Geraets, Will Coumans, Joost J F P Luiken, Jan F C Glatz, Michael Schäfers, Klaas Nicolay, Cornelius Faber, Sven Hermann, Jeanine J Prompers
Aim: Heart failure is associated with altered myocardial substrate metabolism and impaired cardiac energetics. Comorbidities like diabetes may influence the metabolic adaptations during heart failure development. We quantified to what extent changes in substrate preference, lipid accumulation, and energy status predict the longitudinal development of hypertrophy and failure in the non-diabetic and the diabetic heart. Methods and results: Transverse aortic constriction (TAC) was performed in non-diabetic ( db /+) and diabetic ( db/db ) mice to induce pressure overload...
May 26, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28549077/clinical-criteria-for-subtyping-parkinson-s-disease-biomarkers-and-longitudinal-progression
#13
Seyed-Mohammad Fereshtehnejad, Yashar Zeighami, Alain Dagher, Ronald B Postuma
Parkinson's disease varies widely in clinical manifestations, course of progression and biomarker profiles from person to person. Identification of distinct Parkinson's disease subtypes is of great priority to illuminate underlying pathophysiology, predict progression and develop more efficient personalized care approaches. There is currently no clear way to define and divide subtypes in Parkinson's disease. Using data from the Parkinson's Progression Markers Initiative, we aimed to identify distinct subgroups via cluster analysis of a comprehensive dataset at baseline (i...
May 25, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28547886/the-suction-mechanism-of-the-pipid-frog-pipa-pipa-linnaeus-1758
#14
David Cundall, Edward Fernandez, Frances Irish
Most suction-feeding, aquatic vertebrates create suction by rapidly enlarging the oral cavity and pharynx. Forceful enlargement of the pharynx is powered by longitudinal muscles that retract skeletal elements of the hyoid, more caudal branchial arches, and, in many fish, the pectoral girdle. This arrangement was thought to characterize all suction-feeding vertebrates. However, it does not exist in the permanently aquatic, tongueless Pipa pipa, an Amazonian frog that can catch fish. Correlating high-speed (250 and 500 fps) video records with anatomical analysis and functional tests shows that fundamental features of tetrapod body design are altered to allow P...
May 25, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28547854/nucleus-accumbens-functional-connectivity-at-age-20-is-associated-with-trajectory-of-adolescent-cannabis-use-and-predicts-psychosocial-functioning-in-young-adulthood
#15
Sarah D Lichenstein, Samuel Musselman, Daniel S Shaw, Stephanie Sitnick, Erika E Forbes
AIMS: To identify trajectories of cannabis use across adolescence, 2) to measure the influence of cannabis use characteristics on functional connectivity of the nucleus accumbens (NAcc), and 3) to assess whether patterns of functional connectivity related to cannabis use are associated with psychosocial functioning 2 years later. DESIGN: The Pitt Mother & Child Project (PMCP) is a prospective, longitudinal study of male youth at high risk for psychopathology based on family income and gender...
May 26, 2017: Addiction
https://www.readbyqxmd.com/read/28547837/does-body-image-influence-the-relationship-between-body-weight-and-breastfeeding-maintenance-in-new-mothers
#16
Vivien Swanson, Alice Keely, Fiona C Denison
OBJECTIVES: Obese women have lower breastfeeding initiation and maintenance rates than healthy weight women. Research generally focuses on biomedical explanations for this. Psychosocial factors including body image and well-being after childbirth are less well understood as predictors of breastfeeding. In obese and healthy weight women, we investigated changes in body image between 72 hrs post-delivery and 6-8 weeks post-natal, studying how women's body image related to breastfeeding initiation and maintenance...
May 26, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28545715/apol1-genetic-variants-are-not-associated-with-longitudinal-blood-pressure-in-young-black-adults
#17
Teresa K Chen, Michelle M Estrella, Eric Vittinghoff, Feng Lin, Orlando M Gutierrez, Holly Kramer, Cora E Lewis, Jeffrey B Kopp, Norrina B Allen, Cheryl A Winkler, Kirsten B Bibbins-Domingo, Carmen A Peralta
Whether APOL1 polymorphisms contribute to the excess risk of hypertension among blacks is unknown. To assess this we evaluated whether self-reported race and, in blacks, APOL1 risk variants (high-risk [2 risk alleles] versus low-risk [0-1 risk allele]) were associated with longitudinal blood pressure. Blood pressure trajectories were determined using linear mixed-effects (slope) and latent class models (5 distinct groups) during 25 years of follow-up in the Coronary Artery Risk Development in Young Adults Study...
May 23, 2017: Kidney International
https://www.readbyqxmd.com/read/28544830/assessment-of-contributors-of-aortopathy-and-subclinical-left-ventricular-dysfunction-in-normally-functioning-bicuspid-aortic-valves
#18
Kamil Tuluce, Selcen Yakar Tuluce, Ersin Cagri Simsek, Serdar Bayata, Cem Nazli
BACKGROUND: Left ventricular (LV) function and the dimensions of aortic valves from normally functioning bicuspid aortic valve (BAV) patients were compared with those of healthy control patients. A comparison between patients with antero-posterior BAV (BAV-AP) or right-left BAV (BAV-RL) was also performed, and the determinants of aortopathy and LV function were investigated. METHODS: Sixty-eight patients with aortic velocities <2 m/s and trivial or mild aortic regurgitation were included in the study...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28544620/phenotyping-cardiac-and-structural-birth-defects-in-fetal-and-newborn-mice
#19
REVIEW
Xiaoqin Liu, Andrew J Kim, William Reynolds, Yijen Wu, Cecilia W Lo
Mouse models are invaluable for investigating the developmental etiology and molecular pathogenesis of structural birth defects. While this has been deployed for studying a wide spectrum of birth defects, mice are particularly valuable for modeling congenital heart disease, given they have the same four-chamber cardiac anatomy as in humans. We have developed the use of noninvasive fetal ultrasound together with micro-computed tomography (micro-CT) imaging for high throughput phenotyping of mice for congenital heart defects (CHD) and other developmental anomalies...
May 22, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28544276/pregnancy-and-pelvic-girdle-pain-analysis-of-pelvic-belt-on-pain
#20
Jeanne Bertuit, Charlotte Eloise Van Lint, Marcel Rooze, Véronique Feipel
AIMS: To analyse pain and functional capacity in women with pelvic girdle pain and to evaluate the effect of pelvic belt on these parameters. Two types of belts were to compare. BACKGROUND: Pelvic girdle pain is very common during pregnancy. To prevent and relieve pelvic pain, women can use a set of techniques and tools such as a pelvic belt. While scientific evidence is lacking, commercial industries suggest the effectiveness of pelvic belts. DESIGN: Randomized control trial...
May 25, 2017: Journal of Clinical Nursing
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