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Black seed oil

Tafheem Malik, Sheema Hasan, Shahid Pervez, Tasneem Fatima, Darakhshan Jabeen Haleem
The symptoms of Parkinsonism and oral dyskinesia have been showing to be induced by neuroleptics that significantly affect its clinical use. In this study, we investigate whether Nigella sativa-oil (NS) (black cumin seeds)-a traditional medicine used for the seizure treatment in eastern country-may reduce the haloperidol (HAL)-induced extrapyramidal symptoms (EPS)-like behavior in rats. After combine treatment with HAL (1 mg/kg) on NS (0.2 ml/rat), rats displayed a significant decreased EPS-like behavior including movement disorders and oral dyskinesia as compared to controls...
October 18, 2016: Neurochemical Research
Yiye Shao, Yonghao Feng, Yangmei Xie, Qiong Luo, Long Chen, Bing Li, Yinghui Chen
Inflammation plays a pivotal role in status epilepticus (SE). Thymoquinone (TQ) is a bioactive monomer extracted from black seed (Nigella sativa) oil, which has anti-inflammatory properties in the context of various diseases. This study explored the protective effects of TQ in SE and used a lithium-pilocarpine model of SE to investigate the underlying mechanism, which was related to inflammation mediated by the NF-κB signaling pathway. In the present study, latency to SE increased in the TQ-pretreated group compared with the SE group, and the incidence of SE was significantly reduced...
October 18, 2016: Neurochemical Research
Ghulam Zahara Jahangir, Durre Shahwar Ashraf, Idrees Ahmad Nasir, Madeha Sadiq, Sobia Shahzad, Farah Naz, Muhammad Iqbal, Afifa Saeed
The synthetic oral cleansing and teeth whitening products like mouthwashes exert adverse effects on teeth, gums and mucous membrane of oral cavity and their extensive use is being criticized. Determining the effect of frequent use of mouthwashes, human cheek cells and their DNA have been studied. Five mouthwash brands were tested and their effects were examined on membrane and DNA of human cheek cells which were found to be very expressive and severe. The DNA, also, received severe damage and breaks developed in its double stranded structure resulting in detachment of small fragments from DNA...
2016: SpringerPlus
Nameer Khairullah Mohammed, Mohd Yazid Abd Manap, Chin Ping Tan, Belal J Muhialdin, Amaal M Alhelli, Anis Shobirin Meor Hussin
The Nigella sativa L. popularly referred to as black seeds are widely used as a form of traditional nutrition and medicine. N. sativa seeds were used for the extraction of their oil by way of supercritical fluid extraction (SFE) and cold press (CP) to determine the physicochemical properties, antioxidant activity, and thermal behavior. The GC-MS results showed the primary constituents in the Nigella sativa oil (NSO) were Caryophyllene (17.47%) followed by thymoquinone (TQ) (11.80%), 1,4-Cyclohexadiene (7.17%), longifolene (3...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Mahmoud Balbaa, Marwa El-Zeftawy, Doaa Ghareeb, Nabil Taha, Abdel Wahab Mandour
The black cumin (Nigella sativa) "NS" or the black seeds have many pharmacological activities such as antioxidant, anticarcinogenic, antihypertensive, and antidiabetic properties. In this work, streptozotocin-induced diabetic rats fed with a high-fat diet were treated daily with NS oil (NSO) in order to study the effect on the blood glucose, lipid profile, oxidative stress parameters, and the gene expression of some insulin receptor-induced signaling molecules. This treatment was combined also with some drugs (metformin and glimepiride) and the insulin receptor inhibitor I-OMe-AG538...
2016: Oxidative Medicine and Cellular Longevity
Xin Wei, Xiaodong Zhu, Jingyin Yu, Linhai Wang, Yanxin Zhang, Donghua Li, Rong Zhou, Xiurong Zhang
Sesame (Sesamum indicum L.) is one of the main oilseed crops, providing vegetable oil and protein to human. Landrace is the gene source of variety, carrying many desire alleles for genetic improvement. Despite the importance of sesame landrace, genome of sesame landrace remains unexplored and genomic variations between landrace and variety still is not clear. To identify the genomic variations between sesame landrace and variety, two representative sesame landrace accessions, "Baizhima" and "Mishuozhima," were selected and re-sequenced...
2016: Frontiers in Plant Science
Akramosadat Atyabi, Laila Shirbeigi, Fateme Eghbalian
BACKGROUND: Psoriasis is a common chronic inflammatory skin, nails, and joints disease related to the immune system by periods of exacerbations and remissions. It is characterized by thick end, erythematous, and scaling lesions, which affects about 2 to 4 percent of the general population. The disease occurs equally in both sexes and the most common form of the disease is psoriasis vulgaris. The etiology is unknown but genetic and environmental factors, immune system disorders, and gastrointestinal dysfunction appear to be responsible...
May 2016: Iranian Journal of Medical Sciences
Amirhossein Sahebkar, Davide Soranna, Xiaoqiu Liu, Costas Thomopoulos, Luis E Simental-Mendia, Giuseppe Derosa, Pamela Maffioli, Gianfranco Parati
Several reports suggest a beneficial effect of Nigella sativa on cardiometabolic risk factors, including blood pressure (BP). However, the magnitude of the BP-lowering effect of N. sativa remains controversial. We aimed to calculate this effect size of N. sativa through a systematic review and meta-analysis of randomized controlled trials (RCTs). PubMed, Cochrane Collaboration Library, and SCOPUS were used as data sources of RCTs published before 30 August 2015 (in English only) comparing N. sativa treatment with placebo or standard treatment...
November 2016: Journal of Hypertension
Jacob K Akintunde, C Abigail Irechukwu
BACKGROUND: The antipsychotic, haloperidol, is extremely efficient in the treatment of schizophrenia but its application is constrained because of irreversible adverse drug reactions. Hence, in this study, we investigate the differential effects of black seed oil on cholinesterase [acetylcholinesterase (AChE) and butrylcholinesterase (BuChE), ectonucleotidase (5'-nucleotidase), lactate dehydrogenase (LDH) and monoamine oxidase (MAO)] activities and relevant markers of oxidative stress in the cerebrum of haloperidol-induced neuronal-damaged rats...
August 2016: Therapeutic Advances in Drug Safety
Zahra Gholamnezhad, Shahrzad Havakhah, Mohammad Hossein Boskabady
ETHNOPHARMACOLOGICAL RELEVANCE: Nigella sativa (N. sativa) L. (Ranunculaceae), well known as black cumin, has been used as a herbal medicine that has a rich historical background. It has been traditionally and clinically used in the treatment of several diseases. Many reviews have investigated this valuable plant, but none of them focused on its clinical effects. Therefore, the aim of the present review is to provide a comprehensive report of clinical studies on N. sativa and some of its constituents...
August 22, 2016: Journal of Ethnopharmacology
Shahida A Khan, Aziz M Khan, Sajjad Karim, Mohammad Amjad Kamal, Ghazi A Damanhouri, Zeenat Mirza
Nigella sativa (NS) or black cumin is a dark, thin, and crescent-shaped, seeded shrub belonging to the Ranunculaceae family commonly growing on Mediterranean coasts in Saudi Arabia, northern Africa and Asia. They have amazing curative and therapeutic features that make them one of the most popular, safe, non-detrimental, and cytoprotective medicinal plant that can be used for prevention and treatment of many complicated diseases. Originally, N. sativa was used to treat migraines and allergy, and researches have shown its effectiveness in destroying cancer cells as well...
July 2016: Saudi Journal of Biological Sciences
Alireza Showraki, Masoumeh Emamghoreishi, Somayeh Oftadegan
BACKGROUND: Carum carvi L. (caraway), known as black zeera in Iran, has been indicated for the treatment of epilepsy in Iranian folk medicine. This study evaluated whether the aqueous extract and essential oil of caraway seeds have anticonvulsant effects in mice. METHODS: The anticonvulsant effects of the aqueous extract (200, 400, 800, 1600, and 3200 mg/kg, i.p.) and essential oil (25, 50, 100, 200, and 400 mg/kg, i.p.) of caraway were assessed using pentylenetetrazol (PTZ; 95 mg/kg i...
May 2016: Iranian Journal of Medical Sciences
Quanquan Li, Jiankang Wang, Fereidoon Shahidi
The chemical characteristics of cold-pressed blackberry, black raspberry, and blueberry seed oils were evaluated for their fatty acid composition, positional distribution of fatty acids, triacylglycerol (TAG) profile, and minor component profile. The role of minor components, including tocols and pigments, on the oxidative stability was also investigated using high-temperature- and fluorescent-lighting-induced oxidation before and after tested berry seed oils were stripped of their minor components. The results indicated that all tested berry seed oils contained significant levels of palmitic (C16:0), stearic (C18:0), oleic (18:1), linoleic (C18:2ω-6), and α-linolenic (C18:3ω-3) acids, along with a favorable ratio of ω-6/ω-3 fatty acids (1...
July 6, 2016: Journal of Agricultural and Food Chemistry
Hee Jae Lee, Hana Jung, Hyunnho Cho, Kiuk Lee, Ho-Kyung Kwak, Keum Taek Hwang
The objective of this study was to evaluate the status of the markers related to inflammation in db/db mice fed black raspberry seed (BRS) oil, which is rich in α-linolenic acid. Mice were divided into four groups: (1) C57BL/6 mice fed 16 % calories from soybean oil (normal CON); (2) C57BL/KsJ-db/db mice fed 16 % calories from soybean oil (CON); (3) C57BL/KsJ-db/db mice fed 8 % calories from soybean and 8 % calories from BRS oil (BRS 50 %); and (4) C57BL/KsJ-db/db mice fed 16 % calories from BRS oil (BRS 100 %)...
June 2016: Lipids
Magdalena Rudzińska, Minar M M Hassanein, Adel G Abdel-Razek, Katarzyna Ratusz, Aleksander Siger
For the increase of oxidative stability and phytonutrient contents of rapeseed oil 5, 10 and 20 % blends with rice bran oil and black cumin oil were prepared. Profiles of different bioactive lipid components of blends including tocopherols, tocotrienols, phytosterols and phytostanols as well as fatty acid composition were carried out using HPLC and GLC. Rancimat was used for detecting oxidative stability of the fatty material. The blends with black cumin seed oil characterized higher level of α- and γ-tocopherols as well as all isomers of tocotrienols...
February 2016: Journal of Food Science and Technology
Luciana de Almeida Vittori Gouveia, Carolina Alves Cardoso, Glaucia Maria Moraes de Oliveira, Glorimar Rosa, Annie Seixas Bello Moreira
This study is aimed at assessing the scientific evidence on the effect of the intake of sesame seeds and derivatives on oxidative stress of individuals with systemic hypertension, dyslipidemia, and type 2 diabetes mellitus. A systematic review was conducted in seven databases (Lilacs, PubMed, ISI Web of Knowledge, Cochrane Library, Scopus, Trip Database, and Scielo) from September 2013 to January 2014. Clinical trials on the intake of sesame seeds and derivatives assessing the outcomes related to oxidative stress were retrieved...
April 2016: Journal of Medicinal Food
Babar Ali, Qazi Mohd Sajid Jamal, Showkat R Mir, Saiba Shams, Naser A Al-Wabel, Mohammad A Kamal
BACKGROUND: Black cumin oil is obtained from the seeds of Nigella sativa L. which belongs to family Ranunculaceae. The seed oil has been reported to possess antitumor, antioxidant, antibacterial, anti-inflammatory, hypoglycemic, central nervous system depressant, antioxidant, and immunostimulatory activities. These bioactivities have been attributed to the fixed oil, volatile oil, or their components. Seed oil consisted of 15 saturated fatty acids (17%) and 17 unsaturated fatty acids (82...
October 2015: Pharmacognosy Magazine
Amr E Edris, Danuta Kalemba, Janusz Adamiec, Marcin Piątkowski
Oleoresin of Nigella sativa L. (Black cumin) was obtained from the seeds using hexane extraction at room temperature. The oleoresin was emulsified in an aqueous solution containing gum Arabic/maltodextrin (1:1 w/w) and then encapsulated in powder form by spray drying. The characteristics of the obtained powder including moisture content, bulk density, wettability, morphology, encapsulation efficiency were evaluated. The effect of the spray drying on the chemical composition of the volatile oil fraction of N...
August 1, 2016: Food Chemistry
Amirhossein Sahebkar, Guglielmo Beccuti, Luis E Simental-Mendía, Valerio Nobili, Simona Bo
The effects of Nigella sativa (NS) on plasma lipid concentrations are controversial. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to obtain a conclusive result in humans. PubMed-Medline, SCOPUS, Web of Science, and Google Scholar databases were searched (up to August 2015) to identify RCTs investigating the impact of NS on total cholesterol, LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), and triglycerides concentrations. A random-effects model and the generic inverse variance weighting method were used for quantitative data synthesis...
April 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Beatriz Mejia-Garibay, José Ángel Guerrero-Beltrán, Enrique Palou, Aurelio López-Malo
The composition, some physical properties (density, refraction index, and color), antioxidant capacity (DPPH), and fatty acid profile of seeds of black (Brassica nigra) or yellow mustard (Brassica alba) were evaluated, as well as for their oils and residues from oil extraction. Density of the black and yellow mustard oils were 0.912 ± 0.01 and 0.916 ± 0.01 g/mL, respectively; their refraction indexes were 1.4611 ± 0.01 and 1.4617 ± 0.01, respectively; being not significantly different (p > 0.05) between two mustards...
June 2015: Archivos Latinoamericanos de Nutrición
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