keyword
https://read.qxmd.com/read/38530625/acute-high-output-heart-failure-with-pulmonary-hypertension-and-severe-liver-injury-caused-by-amlodipine-poisoning-a-case-report
#1
JOURNAL ARTICLE
Chenlong Wang, Qingcheng Zhu, Dingyu Tan, Joseph Walline, Yachao Wang
Acute high-output heart failure (HOHF) with pulmonary hypertension and liver injury caused by amlodipine poisoning is very rare. We report a 52-year-old woman who suffered from severe shock after an overdose of amlodipine. Hemodynamic monitoring showed that while her left ventricular systolic function and cardiac output were elevated, her systemic vascular resistance decreased significantly. At the same time, the size of her right heart, her central venous pressure, and the oxygen saturation of her central venous circulation all increased abnormally...
March 26, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38521868/single-cell-and-spatial-analyses-revealed-the-co-location-of-cancer-stem-cells-and-spp1-macrophage-in-hypoxic-region-that-determines-the-poor-prognosis-in-hepatocellular-carcinoma
#2
JOURNAL ARTICLE
Guangyu Fan, Tongji Xie, Lin Li, Le Tang, Xiaohong Han, Yuankai Shi
In hepatocellular carcinoma (HCC), classical cancer stem cells (CSC) markers were shared by normal stem cells, targeting which may hinder hepatic regeneration and cause liver failure. Additionally, the spatial structure of CSC still remained elusive. To address these limitations, we undertook a comprehensive study combining single-cell data (56,022 cells from 20 samples) and spatial data (38,191 spots from eight samples) to obtain CSC signature and uncover its spatial structure. Utilizing the CytoTRACE algorithm, we discretely identified CSC, which displayed upregulated proliferation pathways regulated by HIF1A...
March 23, 2024: NPJ Precision Oncology
https://read.qxmd.com/read/38442547/hypoxia-preconditioning-of-human-amniotic-mesenchymal-stem-cells-enhances-proliferation-and-migration-and-promotes-their-homing-via-the-hgf-c-met-signaling-axis-to-augment-the-repair-of-acute-liver-failure
#3
JOURNAL ARTICLE
Qian Wang, Yuwen Li, Hui Yuan, Linya Peng, Zixing Dai, Ye Sun, Rui Liu, Wenting Li, Jun Li, Chuanlong Zhu
BACKGROUND: Transplantation of mesenchymal stem cells (MSCs) is a newly developed strategy for treating acute liver failure (ALF). Nonetheless, the low survival rate of MSCs after transplantation and their poor homing to damaged tissues limit the clinical application of MSCs. The research assessed whether hypoxic preconditioning (HPC) can improve the biological activity of human amniotic mesenchymal stem cells (hA-MSCs), promote their homing ability to the liver of mice with ALF, and influence liver tissue repair...
February 17, 2024: Tissue & Cell
https://read.qxmd.com/read/38426545/senp1-attenuates-hypoxia%C3%A2-reoxygenation-injury-in-liver-sinusoid-endothelial-cells-by-relying-on-the-hif%C3%A2-1%C3%AE-signaling-pathway
#4
JOURNAL ARTICLE
Zhe Qing, Qun Luo, Jian Duan, Jie Lin, Hanfei Huang, Shikun Yang, Zhong Zeng
Liver sinusoidal endothelial cells (LSECs) have an important role in hepatic ischemia‑reperfusion injury (I/R), but the specific molecular mechanism of action is unknown. LSEC proliferation is regulated and fenestration is maintained via the Sentrin/SUMO‑specific protease 1 (SENP1)/hypoxia‑inducible factor‑1α (HIF‑1α) signaling axis under hypoxic conditions. In the present study, a hypoxia‑reoxygenation (H‑R) injury model was established using mouse LSECs to explore the relationship between SENP1 and H‑R injury in vitro , and the specific underlying mechanism was identified, revealing new targets for the clinical attenuation of hepatic I/R injury...
April 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38336284/acute-liver-failure-after-out-of-hospital-cardiac-arrest-an-observational-study
#5
JOURNAL ARTICLE
Marie-Charlotte Delignette, Neven Stevic, Fanny Lebossé, Eric Bonnefoy-Cudraz, Laurent Argaud, Martin Cour
RATIONALE: Apart from hypoxic hepatitis (HH), the hepatic consequences of out-of-hospital cardiac arrest (OHCA) have been little studied. This cohort study aimed to investigate the characteristics of liver dysfunction resulting from OHCA and its association with outcomes. METHODS: Among the conventional static liver function tests used to define acute liver failure (ALF), we determined which one correlated more closely with the reference indocyanine green (ICG) clearance test in a series of OHCA patients from the CYRUS trial (NCT01595958)...
February 7, 2024: Resuscitation
https://read.qxmd.com/read/38301977/met-exo-attenuates-mitochondrial-dysfunction-after-hepatic-ischemia-reperfusion-injury-in-rats-by-modulating-ampk-sirt1-signaling-pathway
#6
JOURNAL ARTICLE
Chenxi Piao, Yue Wang, Xiangyu Lu, Tao Liu, Yajun Ma, Yuepeng Li, Jiantao Zhang, Hongbin Wang
Hepatic ischemia-reperfusion injury (IRI) results in significant postoperative liver dysfunction, and the intricate mechanism of IRI poses challenges in developing effective therapeutic drugs. Mitigating the damage caused by hepatic IRI and promoting the repair of postoperative liver injury have become focal points in recent years, holding crucial clinical significance. Adipose mesenchymal stem cell derived exosomes (ADSCs-Exo) and metformin (Met) can play a mitochondrial protective role in the treatment of hepatic IRI, but whether there is a synergistic mechanism for their intervention is not yet known...
January 30, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38247513/ultrastructural-antioxidant-and-metabolic-responses-of-male-genetically-improved-farmed-tilapia-gift-oreochromis-niloticus-to-acute-hypoxia-stress
#7
JOURNAL ARTICLE
Yifan Tao, Jixiang Hua, Siqi Lu, Qingchun Wang, Yan Li, Bingjie Jiang, Yalun Dong, Jun Qiang, Pao Xu
Tilapia tolerate hypoxia; thus, they are an excellent model for the study of hypoxic adaptation. In this study, we determined the effect of acute hypoxia stress on the antioxidant capacity, metabolism, and gill/liver ultrastructure of male genetically improved farmed tilapia (GIFT, Oreochromis niloticus ). Fish were kept under control (dissolved oxygen (DO): 6.5 mg/L) or hypoxic (DO: 1.0 mg/L) conditions for 72 h. After 2 h of hypoxia stress, antioxidant enzyme activities in the heart and gills decreased, while the malondialdehyde (MDA) content increased...
January 10, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38227578/the-n6-methyladenosine-demethylase-alkbh5-regulates-the-hypoxic-hbv-transcriptome
#8
JOURNAL ARTICLE
Senko Tsukuda, James M Harris, Andrea Magri, Peter Balfe, Aleem Siddiqui, Peter A C Wing, Jane A McKeating
Chronic hepatitis B is a global health problem and current treatments only suppress hepatitis B virus (HBV) infection, highlighting the need for new curative treatments. Oxygen levels influence HBV replication and we previously reported that hypoxia inducible factors (HIFs) activate the basal core promoter (BCP). Here we show that the hypoxic-dependent increase in BCP-derived transcripts is dependent on N6-methyladenosine (m6A) modifications in the 5' stem loop that regulate RNA half-life. Application of a probe-enriched long-read sequencing method to accurately map the HBV transcriptome showed an increased abundance of pre-genomic RNA under hypoxic conditions...
January 2024: PLoS Pathogens
https://read.qxmd.com/read/38093174/hypoxia-responsive-golgi-targeted-prodrug-assembled-with-anthracycline-for-improved-antitumor-and-antimetastasis-efficacy
#9
JOURNAL ARTICLE
Chenqi Guo, Mengying Wu, Zhaofei Guo, Rongping Zhang, Zijun Wang, Xiong Peng, Jianxia Dong, Xun Sun, Zhirong Zhang, Peihong Xiao, Tao Gong
Tumor metastasis is an intricate multistep process regulated via various proteins and enzymes modified and secreted by swollen Golgi apparatus in tumor cells. Thus, Golgi complex is considered as an important target for the remedy of metastasis. Currently, Golgi targeting technologies are mostly employed in Golgi-specific fluorescent probes for diagnosis, but their applications in therapy are rarely reported. Herein, we proposed a prodrug (INR) that can target and destroy the Golgi apparatus, which consisted of indomethacin (IMC) as the Golgi targeting moiety and retinoic acid (RA), a Golgi disrupting agent...
December 13, 2023: ACS Nano
https://read.qxmd.com/read/38077794/sarcoma-protein-kinase-inhibition-alleviates-liver-fibrosis-by-promoting-hepatic-stellate-cells-ferroptosis
#10
JOURNAL ARTICLE
Zhengyuan Cheng, Xiaojuan Zhang, Pingsheng Chen, Haitao Wang, Kuangjing Wang, Yingzhou Shen
Liver fibrosis is a type of chronic pathological liver damage involving liver tissue hypoxia and abnormal extracellular matrix deposits. Hepatic stellate cells (HSCs) activation is critical for liver fibrosis. Currently, inhibiting HSCs activation or inducing HSCs ferroptosis is considered an effective strategy for the treatment of liver fibrosis. Sarcoma protein kinase (Src) is an important member of the tyrosine protein kinase family. Hypoxia causes Src phosphorylation at tyrosine 416 (Tyr 416), and inhibiting Src activation can alleviate liver fibrosis...
2023: Open Life Sciences
https://read.qxmd.com/read/38050141/electroencephalography-in-encephalopathy-and-encephalitis
#11
REVIEW
Hollie Morris, Peter W Kaplan, Nick Kane
Electroencephalography (EEG) is a useful adjunct to clinical neurological examination, particularly as it may detect subtle or subclinical disturbance of cerebral function and it allows monitoring of cerebral activity over time. Continuous EEG combined with quantitative analysis and machine learning may help identify changes in real time, before the emergence of clinical signs and response to interventions. EEG is rarely pathognomonic in encephalopathy/encephalitis but when interpreted correctly and within the clinical context, certain phenotypes may indicate a specific pathophysiology (eg, lateralised periodic discharges in HSV-1, generalised periodic discharges in sporadic Creutzfeldt-Jakob disease, and extreme delta brushes in anti-n-methyl-D-aspartate receptor autoimmune encephalitis)...
January 23, 2024: Practical Neurology
https://read.qxmd.com/read/38045041/remodeling-of-the-liver-fibrosis-microenvironment-based-on-nilotinib-loaded-multicatalytic-nanozymes-with-boosted-antifibrogenic-activity
#12
JOURNAL ARTICLE
Huaqing Jing, Yingzi Ren, Yue Zhou, Min Xu, Sona Krizkova, Zbynek Heger, Qiang Lu, Siyu Wang, Xiaoyang Liang, Vojtech Adam, Nan Li
Liver fibrosis is a reversible pathological process caused by chronic liver damage and a major risk factor for hepatocellular carcinoma (HCC). Hepatic stellate cell (HSC) activation is considered the main target for liver fibrosis therapy. However, the efficiency of this strategy is limited due to the complex microenvironment of liver fibrosis, including excessive extracellular matrix (ECM) deposition and hypoxia-induced imbalanced ECM metabolism. Herein, nilotinib (NIL)-loaded hyaluronic acid (HA)-coated Ag@Pt nanotriangular nanozymes (APNH NTs) were developed to inhibit HSCs activation and remodel the microenvironment of liver fibrosis...
December 2023: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/38021926/triple-threat-triple-pathogen-endocarditis
#13
Jessica M Gonzalez, Gabriel Lowenhaar, Moti Ramgopal, Prasad Chalasani
Polymicrobial endocarditis is rare but is seen in those with risk factors like diabetes mellitus, structural heart disease, congenital heart defects, prosthetic devices, and intravenous drug use. We report the case of a 30-year-old woman with a past medical history of chronic Hepatitis C and IV drug use who presented with a one-week history of generalized weakness, subjective fevers, lower extremity abscesses, and occasional chest pain. Blood cultures were positive for Streptococcus anginosus , Gemella hemolysans , and Pseudomonas aeruginosa ...
October 2023: Curēus
https://read.qxmd.com/read/38014618/strategic-replication-of-the-hepatic-zonation-in-vitro-employing-a-biomimetic-approach
#14
JOURNAL ARTICLE
Shyama Sasikumar, Shibu Chameettachal, Vijayasankar K N, Peter Kingshott, Brett Cromer, Falguni Pati
The varied functions of the liver are dependent on the metabolic heterogeneity exhibited by the hepatocytes within the liver lobule spanning the porto-central axis. This complex phenomenon plays an important role in maintaining the physiological homeostasis of the liver. Standard in vitro culture models fail to mimic this spatial heterogeneity of hepatocytes, assuming a homogeneous population of cells, which leads to inaccurate translation of results. Here, we demonstrate the development of an in vitro model of hepatic zonation by mimicking the microarchitecture of the liver using a 3D printed mini bioreactor and decellularized liver matrix to provide the native microenvironmental cues...
November 28, 2023: ACS Applied Bio Materials
https://read.qxmd.com/read/38001763/chronic-intermittent-hypoxia-induced-dysmetabolism-is-associated-with-hepatic-oxidative-stress-mitochondrial-dysfunction-and-inflammation
#15
JOURNAL ARTICLE
Joana L Fernandes, Fátima O Martins, Elena Olea, Jesus Prieto-Lloret, Patrícia C Braga, Joana F Sacramento, Catarina O Sequeira, Ana P Negrinho, Sofia A Pereira, Marco G Alves, Asunción Rocher, Silvia V Conde
The association between obstructive sleep apnea (OSA) and metabolic disorders is well-established; however, the underlying mechanisms that elucidate this relationship remain incompletely understood. Since the liver is a major organ in the maintenance of metabolic homeostasis, we hypothesize that liver dysfunction plays a crucial role in the pathogenesis of metabolic dysfunction associated with obstructive sleep apnea (OSA). Herein, we explored the underlying mechanisms of this association within the liver. Experiments were performed in male Wistar rats fed with a control or high fat (HF) diet (60% lipid-rich) for 12 weeks...
October 25, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38000361/dexmedetomidine-alleviates-ferroptosis-following-hepatic-ischemia-reperfusion-injury-by-upregulating-nrf2-gpx4-dependent-antioxidant-responses
#16
JOURNAL ARTICLE
Yongjun Zhang, Hua Wei, Mengmei Wang, Yang Yu, Mengyue Gu, Hui Zhong, Shuhua Dong
Hepatic ischemia-reperfusion injury (HIRI) adversely affects liver transplant and resection outcomes. Recently, ferroptosis has been associated with HIRI. Dexmedetomidine (Dex), a potent sedative with anti-inflammatory, antioxidant, and anti-apoptotic properties, protects organs from hypoxic or ischemia-reperfusion (I/R) injuries. However, the mechanisms underlying this protective effect against I/R-induced liver injury remain unclear. This study evaluated the effect of Dex on HIRI in mouse models and the oxygen-glucose deprivation/reperfusion (OGD/R) AML12 cell model...
November 23, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37994257/integrated-single-cell-transcriptomics-reveals-the-hypoxia-induced-inflammation-cancer-transformation-in-nash-derived-hepatocellular-carcinoma
#17
JOURNAL ARTICLE
Yuan Liang, Rui Zhang, Siddhartha Biswas, Qingfa Bu, Zibo Xu, Lei Qiao, Yan Zhou, Jiaqi Tang, Jinren Zhou, Haoming Zhou, Ling Lu
Non-alcoholic fatty liver disease (NAFLD) has emerged as the primary risk factor for hepatocellular carcinoma (HCC), owing to improved vaccination rates of Hepatitis B and the increasing prevalence of metabolic syndrome related to obesity. Although the importance of innate and adaptive immune cells has been emphasized, the malignant transformation of hepatocytes and their intricate cellular network with the immune system remain unclear. The study incorporated four single-cell transcriptomic datasets of liver tissues covering healthy and NAFLD-related disease status...
November 22, 2023: Cell Proliferation
https://read.qxmd.com/read/37961409/the-n6-methyladenosine-demethylase-alkbh5-regulates-the-hypoxic-hbv-transcriptome
#18
Senko Tsukuda, James M Harris, Andrea Magri, Peter Balfe, Peter Ac Wing, Aleem Siddiqui, Jane A McKeating
UNLABELLED: Chronic hepatitis B is a global health problem and current treatments only suppress hepatitis B virus (HBV) infection, highlighting the need for new curative treatments. Oxygen levels influence HBV replication and we previously reported that hypoxia inducible factors (HIFs) activate the basal core promoter to transcribe pre-genomic RNA. Application of a probe-enriched long-read sequencing method to map the HBV transcriptome showed an increased abundance of all viral RNAs under low oxygen or hypoxic conditions...
November 1, 2023: bioRxiv
https://read.qxmd.com/read/37923438/hypoxic-and-temporal-variation-in-the-endocrine-disrupting-toxicity-of-perfluorobutanesulfonate-in-marine-medaka-oryzias-melastigma
#19
JOURNAL ARTICLE
Baili Sun, Jing Li, Yachen Bai, Xiangzhen Zhou, Paul K S Lam, Lianguo Chen
Perfluorobutanesulfonate (PFBS) is an emerging pollutant capable of potently disrupting the sex and thyroid endocrine systems of teleosts. However, the hypoxic and temporal variation in PFBS endocrine disrupting toxicity remain largely unknown. In the present study, adult marine medaka were exposed to environmentally realistic concentrations of PFBS (0 and 10 µg/L) under normoxia or hypoxia conditions for 7 days, aiming to explore the interactive behavior between PFBS and hypoxia. In addition, PFBS singular exposure was extended till 21 days under normoxia to elucidate the time-course progression in PFBS toxicity...
February 2024: Journal of Environmental Sciences (China)
https://read.qxmd.com/read/37915221/histopathological-examination-of-characteristic-brain-mri-findings-in-acute-hyperammonemic-encephalopathy-a-case-report-and-review-of-the-literature
#20
JOURNAL ARTICLE
C H Denk, J Kunzmann, A Maieron, A Wöhrer, V Quinot, S Oberndorfer
INTRODUCTION: Acute hyperammonemic encephalopathy is associated with distinct brain MRI findings, namely, hyperintensity in T2-weighted sequences as well as restricted diffusion in diffusion-weighted imaging with accentuation in the insular cortex and cingulate gyrus. The pathophysiology and the histopathological correlates of these characteristic MRI findings are largely unknown. CASE REPORT: We present a 57-year-old male with a history of chronic alcohol abuse, liver cirrhosis and portal hypertension, and a clinical syndrome (variceal bleeding, depression of consciousness, seizures), elevated plasma ammonia levels, and characteristic brain MRI abnormalities suggestive of acute hyperammonemic encephalopathy...
November 1, 2023: Neuroradiology Journal
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