Chenqi Guo, Mengying Wu, Zhaofei Guo, Rongping Zhang, Zijun Wang, Xiong Peng, Jianxia Dong, Xun Sun, Zhirong Zhang, Peihong Xiao, Tao Gong
Tumor metastasis is an intricate multistep process regulated via various proteins and enzymes modified and secreted by swollen Golgi apparatus in tumor cells. Thus, Golgi complex is considered as an important target for the remedy of metastasis. Currently, Golgi targeting technologies are mostly employed in Golgi-specific fluorescent probes for diagnosis, but their applications in therapy are rarely reported. Herein, we proposed a prodrug (INR) that can target and destroy the Golgi apparatus, which consisted of indomethacin (IMC) as the Golgi targeting moiety and retinoic acid (RA), a Golgi disrupting agent...
December 13, 2023: ACS Nano