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https://www.readbyqxmd.com/read/29913410/incensole-acetate-prevents-beta-amyloid-induced-neurotoxicity-in-human-olfactory-bulb-neural-stem-cells
#1
Mohammed A El-Magd, Sara F Khalifa, Faisal Abdulrahman A Alzahrani, Abdelnaser A Badawy, Eman S El-Shetry, Lamess M Dawood, Mohammed M Alruwaili, Hedib A Alrawaili, Engi F Risha, Fathy M El-Taweel, Hany E Marei
β-Amyloid peptide (Aβ) is a potent neurotoxic protein associated with Alzheimer's disease (AD) which causes oxidative damage to neurons. Incensole acetate (IA) is a major constituent of Boswellia carterii resin, which has anti-inflammatory and protective properties against damage of a large verity of neural subtypes. However, this neuroprotective effect was not studied on human olfactory bulb neural stem cells (hOBNSCs). Herein, we evaluated this effect and studied the underlying mechanisms. Exposure to Aβ25-35 (5 and 10 μM for 24 h) inhibited proliferation (revealed by downregulation of Nestin and Sox2 gene expression), and induced differentiation (marked by increased expression of the immature neuronal marker Map2 and the astrocyte marker Gfap) of hOBNSCs...
June 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29909021/nf%C3%AE%C2%BAb-in-pancreatic-stellate-cells-reduces-infiltration-of-tumors-by-cytotoxic-t-cells-and-killing-of-cancer-cells-via-upregulation-of-cxcl12
#2
Bharti Garg, Bhuwan Giri, Shrey Modi, Vrishketan Sethi, Iris Castro, Oliver Umland, Yuguang Ban, Shweta Lavania, Rajinder Dawra, Sulagna Banerjee, Selwyn Vickers, Nipun B Merchant, Steven Xi Chen, Eli Gilboa, Sundaram Ramakrishnan, Ashok Saluja, Vikas Dudeja
BACKGROUND & AIMS: Immunotherapies are ineffective against pancreatic cancer. We investigated whether the activity of nuclear factor (NF)κB in pancreatic stromal cells contributes to an environment that suppresses anti-tumor immune response. METHODS: Pancreata of C57BL/6 or Rag1-/- mice were given pancreatic injections of a combination of KrasG12D/+; Trp53 R172H/+; Pdx-1cre (KPC) pancreatic cancer cells and pancreatic stellate cells (PSCs) extracted from C57BL/6 (control) or mice with disruption of the gene encoding the NFkB p50 subunit (Nfkb1 or p50-/- mice)...
June 14, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29904777/science-behind-the-cardio-metabolic-benefits-of-omega-3-polyunsaturated-fatty-acids-biochemical-effects-vs-clinical-outcomes
#3
REVIEW
Rohith N Thota, Jessica J A Ferguson, Kylie A Abbott, Cintia B Dias, Manohar L Garg
Lower incidence of cardiovascular disease (CVD) in the Greenland Inuit, Northern Canada and Japan has been attributed to their consumption of seafood rich in long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA). While a large majority of pre-clinical and intervention trials have demonstrated heart health benefits of LCn-3PUFA, some studies have shown no effects or even negative effects. LCn-3PUFA have been shown to favourably modulate blood lipid levels, particularly a reduction in circulating levels of triglycerides...
June 15, 2018: Food & Function
https://www.readbyqxmd.com/read/29904688/data-on-mass-spectrometry-based-proteomics-for-studying-the-involvement-of-cyld-in-the-ubiquitination-events-downstream-of-egfr-activation
#4
Virginia Sanchez-Quiles, Nerea Osinalde, Vyacheslav Akimov, Irina Kratchmarova, Blagoy Blagoev
The present data article corresponds to the proteomic data of the involvement of Cylindromatosis protein (CYLD) in the ubiquitination signaling initiated by EGF stimulation. CYLD tumor suppressor protein has Lys63-chain deubiquitinase activity that has been proved essential for the negative regulation of crucial signaling mechanisms, namely the NFkB pathway. Previous results have suggested the involvement of CYLD in the EGF-dependent signal transduction as well, showing its engagement within the tyrosine-phosphorylated complexes formed following the addition of the growth factor...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29897731/small-molecule-inhibitors-of-nfkb-reverse-iron-overload-and-hepcidin-deregulation-in-a-zebrafish-model-for-hereditary-hemochromatosis-type-3
#5
Sandeep Basu, Kanika Jalodia, Shashi Ranjan, Jing-Ruey J Yeh, Randall T Peterson, Chetana Sachidanandan
Hereditary hemochromatosis (HH) is one of the most common genetic disorders in Caucasian populations, with no viable therapeutic options except phlebotomy. We describe a zebrafish model of human HH (HH) created by targeted mutagenesis of the gene encoding Transferrin receptor 2 (tfr2). TFR2 mutations in humans lead to HH Type 3, a rare but severe form of the disease. The tfr2 mutant model in zebrafish recapitulates the defining features of HH3; iron overload and suppression of hepcidin, the iron regulatory hormone...
June 13, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29891016/melatonin-ameliorates-h-2-o-2-induced-oxidative-stress-through-modulation-of-erk-akt-nfkb-pathway
#6
Mahammed Moniruzzaman, Indranath Ghosal, Debjit Das, Suman Bhusan Chakraborty
BACKGROUND: Improper control on reactive oxygen species (ROS) elimination process and formation of free radicals causes tissue dysfunction. Pineal hormone melatonin is considered a potent regulator of such oxidative damage in different vertebrates. Aim of the current communication is to evaluate the levels of oxidative stress and ROS induced damage, and amelioration of oxidative status through melatonin induced activation of signaling pathways. Hepatocytes were isolated from adult Labeo rohita and exposed to H2 O2 at three different doses (12...
June 11, 2018: Biological Research
https://www.readbyqxmd.com/read/29890290/the-selective-glucocorticoid-receptor-modulator-cort-113176-reduces-neurodegeneration-and-neuroinflammation-in-wobbler-mice-spinal-cord
#7
Maria Meyer, Agustina Lara, Hazel Hunt, Joseph Belanoff, E Ronald de Kloet, Maria Claudia Gonzalez Deniselle, Alejandro F De Nicola
Wobbler mice are experimental models for amyotrophic lateral sclerosis. As such they show motoneuron degeneration, motor deficits, and astrogliosis and microgliosis of the spinal cord. Additionally, Wobbler mice show increased plasma, spinal cord and brain corticosterone levels and focal adrenocortical hyperplasia, suggesting a pathogenic role for glucocorticoids in this disorder. Considering this endocrine background, we examined whether the glucocorticoid receptor (GR) modulator CORT 113176 prevents spinal cord neuropathology of Wobblers...
June 8, 2018: Neuroscience
https://www.readbyqxmd.com/read/29850989/lps-induced-inflammation-abolishes-the-effect-of-dyrk1a-on-ikb-stability-in-the-brain-of-mice
#8
Alizée Latour, Yuchen Gu, Nadim Kassis, Fabrice Daubigney, Catherine Colin, Blandine Gausserès, Sandrine Middendorp, Jean-Louis Paul, Valérie Hindié, Jean-Christophe Rain, Jean-Maurice Delabar, Eugene Yu, Mariona Arbones, Michel Mallat, Nathalie Janel
Down syndrome is characterized by premature aging and dementia with neurological features that mimic those found in Alzheimer's disease. This pathology in Down syndrome could be related to inflammation, which plays a role in other neurodegenerative diseases. We previously found a link between the NFkB pathway, long considered a prototypical proinflammatory signaling pathway, and the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). DYRK1A is associated with early onset of Alzheimer's disease in Down syndrome patients...
May 30, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29807573/cell-cycle-and-apoptosis-regulator-2-at-the-interface-between-dna-damage-response-and-cell-physiology
#9
REVIEW
Martina Magni, Giacomo Buscemi, Laura Zannini
Cell cycle and apoptosis regulator 2 (CCAR2 or DBC1) is a human protein recently emerged as a novel and important player of the DNA damage response (DDR). Indeed, upon genotoxic stress, CCAR2, phosphorylated by the apical DDR kinases ATM and ATR, increases its binding to the NAD+-dependent histone deacetylase SIRT1 and inhibits SIRT1 activity. This event promotes the acetylation and activation of p53, a SIRT1 target, and the subsequent induction of p53 dependent apoptosis. In addition, CCAR2 influences DNA repair pathway choice and promotes the chromatin relaxation necessary for the repair of heterochromatic DNA lesions...
April 2018: Mutation Research
https://www.readbyqxmd.com/read/29802324/advanced-glycation-end-products-induced-insulin-resistance-involves-repression-of-skeletal-muscle-glut4-expression
#10
Danilo C Pinto-Junior, Karolline S Silva, Maria L Michalani, Caio Y Yonamine, João V Esteves, Nelly T Fabre, Karina Thieme, Sérgio Catanozi, Maristela M Okamoto, Patricia M Seraphim, Maria L Corrêa-Giannella, Marisa Passarelli, Ubiratan F Machado
Little is known about advanced glycation end products (AGEs) participation in glucose homeostasis, a process in which skeletal muscle glucose transporter GLUT4 (Scl2a4 gene) plays a key role. This study investigated (1) the in vivo and in vitro effects of AGEs on Slc2a4/GLUT4 expression in skeletal muscle of healthy rats, and (2) the potential involvement of endoplasmic reticulum and inflammatory stress in the observed regulations. For in vivo analysis, rats were treated with advanced glycated rat albumin (AGE-albumin) for 12 weeks; for in vitro analysis, soleus muscles from normal rats were incubated with bovine AGE-albumin for 2...
May 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29797599/expression-of-micrornas-and-irak1-pathway-genes-are-altered-in-gastric-cancer-patients-with-helicobacter-pylori-infection
#11
Reza Ranjbar, AmirReza Hesari, Faezeh Ghasemi, Amirhossein Sahebkar
Gastric cancer (GC) is among the most common cancer types in the world and one of the most lethal gastrointestinal cancers. MicroRNAs (miRNAs) can be of great importance in the early detection of GC. This study aimed to investigate some miRNAs and the genes involved in IRAK1 pathways in the serum of GC patients with Helicobacter pylori (H. pylori) infections compared to the control group. Total RNA was extracted from the serum of GC patients with H. pylori infection and healthy volunteers. The expression levels of miRNAs and the genes were assessed using Real time RT-PCR with specific primers...
May 24, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29790115/n-2-hydroxyphenyl-acetamide-and-its-gold-nanoparticle-conjugation-prevent-glycerol-induced-acute-kidney-injury-by-attenuating-inflammation-and-oxidative-injury-in-mice
#12
Rehan Ahmed Siddiqui, Shabana Usman Simjee, Nurul Kabir, Muhammad Ateeq, M Raza Shah, Syed Saad Hussain
The protective activity of N-(2-hydroxyphenyl)acetamide (NA-2) and NA-2-coated gold nanoparticles (NA-2-AuNPs) in glycerol-treated model of acute kidney injury (AKI) in mice was investigated. NA-2 (50 mg/kg) and NA-2-AuNPs (30 mg/kg) were given to the animals for four days followed by 24-h water deprivation and injection of 50% glycerol (10 ml/kg im). The animals were sacrificed on the next day. Blood and kidneys were collected for biochemical investigations (urea and creatinine), histological studies (hematoxylin and eosin; and periodic acid-Schiff staining), immunohistochemistry (actin and cyclooxygenase-2, Cox-2), and real-time RT-PCR (inducible nitric oxide synthase, iNOS; nuclear factor-κB p50, NFκB; hemeoxygenase-1, HO-1; and kidney injury molecule-1, Kim-1)...
May 22, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29784049/identification-and-therapeutic-modulation-of-a-pro-inflammatory-subset-of-disease-associated-microglia-in-alzheimer-s-disease
#13
Srikant Rangaraju, Eric B Dammer, Syed Ali Raza, Priyadharshini Rathakrishnan, Hailian Xiao, Tianwen Gao, Duc M Duong, Michael W Pennington, James J Lah, Nicholas T Seyfried, Allan I Levey
BACKGROUND: Disease-associated-microglia (DAM) represent transcriptionally-distinct and neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's disease (AD). An understanding of heterogeneity within DAM and their key regulators may guide pre-clinical experimentation and drug discovery. METHODS: Weighted co-expression network analysis (WGCNA) was applied to existing microglial transcriptomic datasets from neuroinflammatory and neurodegenerative disease mouse models to identify modules of highly co-expressed genes...
May 21, 2018: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29779937/estrogen-receptor-positive-breast-tumors-resist-chemotherapy-by-the-overexpression-of-p53-in-cancer-stem-cells
#14
Fatma Ashour, Mohammed H Awwad, Hayam E L Sharawy, Mohamed Kamal
BACKGROUND AND OBJECTIVES: Breast cancer (BC) is classified according to estrogen receptor (ER) status into ER+ and ER- tumors. ER+ tumors have a worse response to chemotherapy compared to ER- tumors. BCL-2, TP53, BAX and NF-ΚB are involved in drug resistance in the ER+ tumors. Recently it was shown that Cancer Stem Cells (CSCs) play an important role in drug resistance. In this study we tested the hypothesis that CSCs of the ER+ tumors resist drug through the overexpression of BCL-2, TP53, BAX and NF-ΚB...
May 17, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29774136/the-impact-of-mir-9-regulation-in-normal-and-malignant-hematopoiesis
#15
Abbas Khosravi, Shaban Alizadeh, Arsalan Jalili, Reza Shirzad, Najmaldin Saki
MicroRNA-9 (MiR-9) dysregulation has been observed in various cancers. Recently, MiR-9 is considered to have a part in hematopoiesis and hematologic malignancies. However, its importance in blood neoplasms is not yet well defined. Thus, this study was conducted in order to assess the significance of MiR-9 role in the development of hematologic neoplasia, prognosis, and treatment approaches. We have shown that a large number of MiR-9 targets (such as FOXOs, SIRT1, CCND1, ID2, CCNG1, Ets, and NFkB) play essential roles in leukemogenesis and that it is overexpressed in different leukemias...
January 30, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/29773318/nickel-toxicity-in-p-lividus-embryos-dose-dependent-effects-and-gene-expression-analysis
#16
Rosa Bonaventura, Francesca Zito, Marco Chiaramonte, Caterina Costa, Roberta Russo
Many industrial activities release Nickel (Ni) in the environment with harmful effects for terrestrial and marine organisms. Despite many studies on the mechanisms of Ni toxicity are available, the understanding about its toxic effects on marine organisms is more limited. We used Paracentrotus lividus as a model to analyze the effects on the stress pathways in embryos continuously exposed to different Ni doses, ranging from 0.03 to 0.5 mM. We deeply examined the altered embryonic morphologies at 24 and 48 h after Ni exposure...
May 4, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29716632/multi-cellular-human-bronchial-models-exposed-to-diesel-exhaust-particles-assessment-of-inflammation-oxidative-stress-and-macrophage-polarization
#17
Jie Ji, Swapna Upadhyay, Xiaomiao Xiong, Maria Malmlöf, Thomas Sandström, Per Gerde, Lena Palmberg
BACKGROUND: Diesel exhaust particles (DEP) are a major component of outdoor air pollution. DEP mediated pulmonary effects are plausibly linked to inflammatory and oxidative stress response in which macrophages (MQ), epithelial cells and their cell-cell interaction plays a crucial role. Therefore, in this study we aimed at studying the cellular crosstalk between airway epithelial cells with MQ and MQ polarization following exposure to aerosolized DEP by assessing inflammation, oxidative stress, and MQ polarization response markers...
May 2, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29710494/novel-angiotensin-receptor-blocker-azilsartan-induces-oxidative-stress-and-nfkb-mediated-apoptosis-in-hepatocellular-carcinoma-cell-line-hepg2
#18
Elham Ahmadian, Ahmad Yari Khosroushahi, Aziz Eftekhari, Safar Farajnia, Hossein Babaei, Mohammad Ali Eghbal
Overexpression of renin angiotensin system (RAS) components and nuclear factor-kappa B (NF-kB) has a key role in various cancers. Blockade of RAS and NF-kB pathway has been suggested to reduce cancer cell proliferation. This study aimed to investigate the role of angiotensin II and NF-kB pathway in liver hepatocellular carcinoma cell line (HepG2) proliferation by using azilsartan (as a novel Ag II antagonist) and Bay 11-7082 (as NF-kB inhibitor). HepG2 cells were treated with different concentrations of azilsartan and Bay 11-7082...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29692266/insights-into-the-biological-evaluation-of-pterocarpanquinones-and-carbapterocarpans-with-anti-tumor-activity-against-mdr-leukemias
#19
Vivian M Rumjanek, Raquel C Maia, Eduardo J Salustiano, Paulo R R Costa
In an attempt to find anticancer agents that could overcome multidrug resistance (MDR), two new classes of modified isoflavonoids were designed and synthesized, and their effectiveness evaluated against a vast array of tumor cell lines. Pterocarpanquinone (LQB-118) and 11a-aza-5-carbapterocarpan (LQB-223) were the most promising. LQB-118 induced cell death, in vitro, in the mM range, to a number of human cancer cell lines as well as to fresh tumor cells obtained from patients with acute or chronic myeloid leukemia, independent on whether they exhibit or not the MDR phenotype...
April 20, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29687464/protective-effects-of-sea-cucumber-holothuria-atra-extract-on-testicular-dysfunction-induced-by-immune-suppressant-drugs-in-wistar-rats
#20
D Y Saad, M M Soliman, A A Mohamed, G B Youssef
The current study was aimed to evaluate the protective effect of Holothurian atra (HA) extract; naturally occurring marine resource, against methotrexate (MTX) induced testicular dysfunction. Mature rats received either MTX (20 mg/kg, intraperitoneally) or saline on the 7th day of experiment al design. Seven days prior and after MTX-injection, rats received HA at dose of 300 mg/kg intragastrically (HA + MTX group; HA group alone). Serum was extracted and testicular tissues were examined for the changes in serum biochemistry (liver & kidney biomarkers, testicular hormones and antioxidants), molecular and histopthological alterations using RT-PCR and immunohistochemistry...
April 23, 2018: Andrologia
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