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https://www.readbyqxmd.com/read/28931091/mt-cell-responses-targeting-hiv-nef-uniquely-correlate-with-infected-cell-frequencies-after-long-term-antiretroviral-therapy
#1
Allison S Thomas, Kimberley L Jones, Rajesh T Gandhi, Deborah K McMahon, Joshua C Cyktor, Dora Chan, Szu-Han Huang, Ronald Truong, Alberto Bosque, Amanda B Macedo, Colin Kovacs, Erika Benko, Joseph J Eron, Ronald J Bosch, Christina M Lalama, Samuel Simmens, Bruce D Walker, John W Mellors, R Brad Jones
HIV-specific CD8+ T-cell responses limit viral replication in untreated infection. After the initiation of antiretroviral therapy (ART), these responses decay and the infected cell population that remains is commonly considered to be invisible to T-cells. We hypothesized that HIV antigen recognition may persist in ART-treated individuals due to low-level or episodic protein expression. We posited that if persistent recognition were occurring it would be preferentially directed against the early HIV gene products Nef, Tat, and Rev as compared to late gene products, such as Gag, Pol, and Env, which have higher barriers to expression...
September 20, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28930690/the-self-inactivating-kamicas9-system-for-the-editing-of-cns-disease-genes
#2
Nicolas Merienne, Gabriel Vachey, Lucie de Longprez, Cécile Meunier, Virginie Zimmer, Guillaume Perriard, Mathieu Canales, Amandine Mathias, Lucas Herrgott, Tim Beltraminelli, Axelle Maulet, Thomas Dequesne, Catherine Pythoud, Maria Rey, Luc Pellerin, Emmanuel Brouillet, Anselme L Perrier, Renaud du Pasquier, Nicole Déglon
Neurodegenerative disorders are a major public health problem because of the high frequency of these diseases. Genome editing with the CRISPR/Cas9 system is making it possible to modify the sequence of genes linked to these disorders. We designed the KamiCas9 self-inactivating editing system to achieve transient expression of the Cas9 protein and high editing efficiency. In the first application, the gene responsible for Huntington's disease (HD) was targeted in adult mouse neuronal and glial cells. Mutant huntingtin (HTT) was efficiently inactivated in mouse models of HD, leading to an improvement in key markers of the disease...
September 19, 2017: Cell Reports
https://www.readbyqxmd.com/read/28930610/rps6ka4-mir1237-and-aurkc-promoter-regions-are-differentially-methylated-in-wilms-tumor
#3
Hanna S Pereira, Sheila C Soares Lima, Paulo S de Faria, Leila Ca Cardoso, Hector N Seuanez
Wilms' tumor (WT) is the most frequent renal cancer in childhood, the occurrence of which is characterized by a relatively low frequency of associated mutations. While epigenetic alterations have been postulated to play a relevant role in the emergence of this tumor, the mechanisms involved in WT development remain largely unknown. In this study, the DNA methylation profile of WT was characterized with Beadchip array. Comparisons between WT with normal kidney identified 827 differentially methylated regions, most of which were attributable in hypermethylation in CpG islands...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28930298/comparison-of-questionnaire-based-estimation-of-pesticide-residue-intake-from-fruits-and-vegetables-with-urinary-concentrations-of-pesticide-biomarkers
#4
Yu-Han Chiu, Paige L Williams, Lidia Mínguez-Alarcón, Matthew Gillman, Qi Sun, Maria Ospina, Antonia M Calafat, Russ Hauser, Jorge E Chavarro
We developed a pesticide residue burden score (PRBS) based on a food frequency questionnaire and surveillance data on food pesticide residues to characterize dietary exposure over the past year. In the present study, we evaluated the association of the PRBS with urinary concentrations of pesticide biomarkers. Fruit and vegetable (FV) intake was classified as having high (PRBS≥4) or low (PRBS<4) pesticide residues for 90 men from the EARTH study. Two urine samples per man were analyzed for seven biomarkers of organophosphate and pyrethroid insecticides, and the herbicide 2,4-dichlorophenoxyacetic acid...
September 20, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28930169/comparison-of-physiological-and-psychological-relaxation-using-measurements-of-heart-rate-variability-prefrontal-cortex-activity-and-subjective-indexes-after-completing-tasks-with-and-without-foliage-plants
#5
Sin-Ae Park, Chorong Song, Yun-Ah Oh, Yoshifumi Miyazaki, Ki-Cheol Son
The objective of this study was to compare physiological and psychological relaxation by assessing heart rate variability (HRV), prefrontal cortex activity, and subjective indexes while subjects performed a task with and without foliage plants. In a crossover experimental design, 24 university students performed a task transferring pots with and without a foliage plant for 3 min. HRV and oxyhemoglobin (oxy-Hb) concentration in the prefrontal cortex were continuously measured. Immediately thereafter, subjective evaluation of emotions was performed using a modified semantic differential (SD) method and a profile of mood state questionnaire (POMS)...
September 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28929926/three-dimensional-kinematic-analysis-and-power-output-of-elite-flat-water-kayakers
#6
Anna Bjerkefors, Olga Tarassova, Johanna S Rosén, Pascal Zakaria, Anton Arndt
The purpose was to examine power output and three-dimensional (3D) kinematic variables in the upper limbs, lower limbs and trunk in elite flat-water kayakers during kayak ergometer paddling. An additional purpose was to analyse possible changes in kinematics with increased intensity and differences between body sides. Six male and four female international level flat-water kayakers participated. Kinematic and kinetic data were collected during three tasks; low (IntL), high (IntH) and maximal (IntM) intensities...
September 20, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28929806/clustered-microcysts-on-breast-ultrasound-what-is-an-appropriate-management-recommendation
#7
Heather I Greenwood, Amie Y Lee, Iryna V Lobach, Bianca M Carpentier, Rita I Freimanis, Loretta M Strachowski
OBJECTIVE: The objective of our study was to determine outcomes of lesions identified as clustered microcysts on breast ultrasound to augment the existing literature and help guide appropriate management recommendations. MATERIALS AND METHODS: We retrospectively identified cases at our institution, from January 2003 through December 2013, of all lesions classified as clustered microcysts at breast ultrasound. Breast ultrasound examinations were performed by the interpreting physician...
September 20, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28929790/the-variability-of-pm10-and-pm2-5-concentrations-in-selected-polish-agglomerations-the-role-of-meteorological-conditions-2006-2016
#8
Joanna Jędruszkiewicz, Bartosz Czernecki, Michał Marosz
The research focuses on the analysis of PM10 and PM2.5 concentrations variability at 11 stations in selected urbanized areas of Poland (Tricity, Poznań, Łódź, Kraków). Methods comprised: the analysis of basic statistical characteristics in yearly/monthly/daily/hourly scale and threshold exceedance frequencies. Also, correlations between PM10 and meteorological variables were investigated. GEV distribution analysis allowed the estimation of the return levels of monthly maxima of PM10 and PM2.5. Results show that in Tricity there are fewer than 5 % of days with PM10 and PM2...
September 20, 2017: International Journal of Environmental Health Research
https://www.readbyqxmd.com/read/28929623/influence-of-combined-iron-supplementation-and-simulated-hypoxia-on-the-haematological-module-of-the-athlete-biological-passport
#9
Laura A Garvican-Lewis, Victor L Vuong, Andrew D Govus, Yorck Olaf Schumacher, David Hughes, Greg Lovell, Daniel Eichner, Christopher J Gore
The integrity of Athlete Biological Passport (ABP) is underpinned by understanding normal fluctuations of its biomarkers to environmental or medical conditions, e.g. altitude training or iron deficiency. The combined impact of altitude and iron supplementation on the ABP was evaluated in endurance-trained athletes (n=34) undertaking 3-weeks of simulated live-high: train-low (14 h.d(-1) , 3000m). Athletes received either oral, intravenous (IV) or placebo iron supplementation, commencing two weeks prior and continuing throughout hypoxic exposure...
September 19, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28929440/the-influence-of-visual-flow-and-perceptual-load-on-locomotion-speed
#10
Casimir J H Ludwig, Nicholas Alexander, Kate L Howard, Alicja A Jedrzejewska, Isha Mundkur, David Redmill
Visual flow is used to perceive and regulate movement speed during locomotion. We assessed the extent to which variation in flow from the ground plane, arising from static visual textures, influences locomotion speed under conditions of concurrent perceptual load. In two experiments, participants walked over a 12-m projected walkway that consisted of stripes that were oriented orthogonal to the walking direction. In the critical conditions, the frequency of the stripes increased or decreased. We observed small, but consistent effects on walking speed, so that participants were walking slower when the frequency increased compared to when the frequency decreased...
September 19, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28929363/all-in-one-low-intensity-pulsed-ultrasound-stimulation-system-using-piezoelectric-micromachined-ultrasonic-transducer-pmut-arrays-for-targeted-cell-stimulation
#11
Wonjun Lee, Seungjun Yoo, Joontaek Jung, Woojin Kang, Wei Wang, Cheil Moon, Hongsoo Choi
A novel cell-stimulation system was fabricated using 10 × 29 piezoelectric micromachined ultrasonic transducer (pMUT) arrays for targeted ultrasonic cell stimulation. Both the diameter of a single pMUT element and the edge-to-edge gap were 120 μm, and the size of a pMUT array was 2.27 × 6.84 mm, to be placed at the bottom of a Transwell. The measured resonance frequency of a single pMUT element was 1.48 ± 0.13 MHz and the measured acoustic intensity of the pMUT array was 0.15 ± 0.03 MPa at 1 mm away from the transducer...
September 19, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28929267/increasing-distribution-of-drugs-released-from-in-situ-forming-plga-implants-using-therapeutic-ultrasound
#12
Chawan Manaspon, Christopher Hernandez, Pinunta Nittayacharn, Selva Jeganathan, Norased Nasongkla, Agata A Exner
One of the challenges in developing sustained-release local drug delivery systems is the limited treatment volume that can be achieved. In this work, we examine the effectiveness of using low frequency, high intensity ultrasound to promote the spatial penetration of drug molecules away from the implant/injection site boundary upon release from injectable, phase inverting poly(lactic acid-co-glycolic acid) (PLGA) implants. Fluorescein-loaded PLGA solutions were injected into poly(acrylamide) phantoms, and the constructs were treated daily for 14 days with ultrasound at 2...
September 19, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28929252/knowledge-about-cervical-cancer-risk-factors-and-practices-of-pap-testing-among-turkish-immigrant-women-in-the-united-states
#13
Aynur Uysal Toraman, Nilufer Yildirim
The objective of this study was to examine knowledge about cervical cancer risk factors and practices of Pap testing among female Turkish immigrants in the state of Florida in the United States of America (USA). This descriptive study was conducted between April and September 2012. The study sampling was consist of 156 Turkish women living in the state of Florida. A questionnaire-based survey was conducted among the population of Turkish immigrant women. On the survey form comprised of a total of 37 questions and three sections there are questions pertaining to the socio-demographic characteristics of the individuals, their knowledge on the cervical cancer risk factors and their approach to getting Pap smear tests...
September 19, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28929240/a-casscf-caspt2-investigation-on-electron-detachments-from-scsi-n-n%C3%A2-%C3%A2-4-6-clusters
#14
Minh Thao Nguyen, Quoc Tri Tran, Van Tan Tran
In this work, the low-lying states of several isomers of ScSi n(-/0) (n = 4-6) were investigated with the B3LYP functional and CASPT2 method. The ground states of the anionic clusters were predicted to be the singlet states of the trigonal bipyramid ScSi4(-) (A-ScSi4(-)), the face-capped trigonal bipyramid ScSi5(-) (A-ScSi5(-)), and the pentagonal bipyramid ScSi6(-) (A-ScSi6(-)) isomer. Based on the anionic ground states, all the relevant electron detachment processes were identified. The corresponding adiabatic and vertical detachment energies (ADEs and VDEs) of the anionic clusters were computed at the CASPT2 level...
September 20, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28929167/frequency-of-venous-thromboembolism-events-during-acute-inpatient-rehabilitation-in-a-comprehensive-cancer-centre
#15
Amy H Ng, Liat Goldman, Jack B Fu, Thein H Oo, Gary B Chisholm, Diane D Liu, Anuja Bedi, Eduardo Bruera
OBJECTIVE: To determine the frequency of venous thromboembolism, possible predictors, and the association between venous thromboembolism and Functional Independence Measure (FIM) scores and length of stay among cancer patients admitted to the inpatient rehabilitation unit at a cancer centre. DESIGN: Retrospective analysis of patients admitted to acute inpatient rehabilitation from September 2011 to June 2013. Subject/patients: Cancer patients in the acute inpatient rehabilitation unit within a tertiary cancer centre...
September 20, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28928944/polyp-bailout-in%C3%A2-pocillopora-damicornis-following-thermal-stress
#16
Alexander J Fordyce, Emma F Camp, Tracy D Ainsworth
Polyp bailout is an established but understudied coral stress response that involves the detachment of individual polyps from the colonial form as means of escaping unfavourable conditions. This may influence both the mortality and asexual recruitment of coral genotypes across a range of species. It was first described by Goreau & Goreau (1959) and has been observed in response to numerous stressors including high salinity and low pH. However, polyp bailout has not previously been described in association with thermal stress and the coral bleaching response, which is becoming increasingly common around the world...
2017: F1000Research
https://www.readbyqxmd.com/read/28928878/papillary-urothelial-neoplasm-of-low-malignant-potential-punlmp-after-initial-tur-bt-comparative-analyses-with-noninvasive-low-grade-papillary-urothelial-carcinoma-lgpuc
#17
Jung Kwon Kim, Kyung Chul Moon, Chang Wook Jeong, Cheol Kwak, Hyun Hoe Kim, Ja Hyeon Ku
Purpose: To verify if the distinction between papillary urothelial neoplasm of low malignant potential (PUNLMP) and noninvasive low-grade papillary urothelial carcinoma (LGPUC) reflects a different biologic activity. Materials and Methods: We reviewed and analyzed the clinical data from 678 patients who had a diagnosis of PUNLMP (n=53) or noninvasive LGPUC (n=625) after initial TUR-BT for bladder neoplasm between 2000 and 2012. Results: The noninvasive LGPUC group showed a higher frequency of recurrence in comparison with the PUNLMP group (46...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28928850/spiral-computed-tomography-evaluation-of-rabbit-vx2-hepatic-tumors-treated-with-20-khz-ultrasound-and-microbubbles
#18
Zhi-Yong Shen, Chun Liu, Ming-Feng Wu, Hai-Feng Shi, Yu-Feng Zhou, Wei Zhuang, Gan-Lin Xia
The aim of the present study was to explore the therapeutic effect of 20 kHz ultrasound (US) and microbubbles (MBs) on rabbit VX2 liver tumors by spiral computed tomography (CT) scanning. A total of 16 New Zealand rabbits with hepatic VX2 tumors were divided into four groups: Control, MB, low-frequency US and US + MB. The treatment effect was evaluated by spiral CT scanning prior to, during and following treatment (at 0 weeks and the end of 1 and 2 weeks). The tumor growth rate was recorded. The specimens of VX2 tumors were collected for histological examination and transmission electron microscopy (TEM)...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28928764/exploring-and-harnessing-haplotype-diversity-to-improve-yield-stability-in-crops
#19
REVIEW
Lunwen Qian, Lee T Hickey, Andreas Stahl, Christian R Werner, Ben Hayes, Rod J Snowdon, Kai P Voss-Fels
In order to meet future food, feed, fiber, and bioenergy demands, global yields of all major crops need to be increased significantly. At the same time, the increasing frequency of extreme weather events such as heat and drought necessitates improvements in the environmental resilience of modern crop cultivars. Achieving sustainably increase yields implies rapid improvement of quantitative traits with a very complex genetic architecture and strong environmental interaction. Latest advances in genome analysis technologies today provide molecular information at an ultrahigh resolution, revolutionizing crop genomic research, and paving the way for advanced quantitative genetic approaches...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28928685/how-children-become-sensitive-to-the-morphological-structure-of-the-words-that-they-read
#20
S H Deacon, Kathryn A Francis
Background: We tested the predictions of models of word reading development as to the effects of repeated exposure on reading of derived words. Aim: Our goal was to examine the impacts of variables that quantify different aspects of this exposure: base frequency, family frequency, and family size. Methods and Samples: In Experiment 1, we asked 75 children in Grades 3 and 5 to read derived words with low surface frequencies (e.g., questionable) that varied in base frequency, family frequency, and family size...
2017: Frontiers in Psychology
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