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https://www.readbyqxmd.com/read/29029116/upregulation-of-irs1-enhances-igf1-response-in-y537s-and-d538g-esr1-mutant-breast-cancer-cells
#1
Zheqi Li, Kevin M Levine, Amir Bahreini, Peilu Wang, David Chu, Ben Ho Park, Steffi Oesterreich, Adrian V Lee
Increased evidence suggests that somatic mutations in the ligand binding domain of estrogen receptor (ERα/ESR1) are critical mediators of endocrine-resistant breast cancer progression. Insulin-like growth factor-1 (IGF1) is an essential regulator of breast development and tumorigenesis, and also has a role in endocrine resistance. A recent study showed enhanced crosstalk between IGF1 and ERα in ESR1 mutant cells, but detailed mechanisms are incompletely understood. Using genome-edited MCF-7 and T47D cell lines harboring Y537S and D538G ESR1 mutations, we characterized altered IGF1 signaling...
September 27, 2017: Endocrinology
https://www.readbyqxmd.com/read/29028222/role-of-rbp2-induced-er-and-igf1r-erbb-signaling-in-tamoxifen-resistance-in-breast-cancer
#2
Hee-Joo Choi, Hyeong-Seok Joo, Hee-Young Won, Kyueng-Whan Min, Hyung-Yong Kim, Taekwon Son, Young-Ha Oh, Jeong-Yeon Lee, Gu Kong
Background: Despite the benefit of endocrine therapy, acquired resistance during or after treatment still remains a major challenge in estrogen receptor (ER)-positive breast cancer. We investigated the potential role of histone demethylase retinoblastoma-binding protein 2 (RBP2) in endocrine therapy resistance of breast cancer. Methods: Survival of breast cancer patients according to RBP2 expression was analyzed in three different breast cancer cohorts including METABRIC (n = 1980) and KM plotter (n = 1764)...
April 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29027594/treatment-and-survival-disparities-by-ethnicity-in-new-zealand-women-with-stage-i-iii-breast-cancer-tumour-subtypes
#3
Ross Lawrenson, Chunhuan Lao, Ian Campbell, Vernon Harvey, Sanjeewa Seneviratne, Melissa Edwards, Mark Elwood, Nina Scott, Jacquie Kidd, Diana Sarfati, Marion Kuper-Hommel
PURPOSE: This study aims to look at the distribution of different subtypes of stage I-III breast cancer in Māori and Pacific versus non-Māori/Pacific women, and to examine cancer outcomes by ethnicity within these different subtypes. METHOD: This study included 9,015 women diagnosed with stage I-III breast cancer between June 2000 and May 2013, recorded in the combined Waikato and Auckland Breast Cancer Registers, who had complete data on ER, PR and HER2 status...
October 13, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29021715/the-clinicopathological-significance-of-ube2c-in-breast-cancer-a-study-based-on-immunohistochemistry-microarray-and-rna-sequencing-data
#4
Chao-Hua Mo, Li Gao, Xiao-Fei Zhu, Kang-Lai Wei, Jing-Jing Zeng, Gang Chen, Zhen-Bo Feng
BACKGROUND: Ubiquitin-conjugating enzyme E2C (UBE2C) has been previously reported to correlate with the malignant progression of various human cancers, however, the exact molecular function of UBE2C in breast carcinoma (BRCA) remained elusive. We aimed to investigate UBE2C expression in BRCA and its clinical significance. METHODS: The expression of UBE2C in 209 BRCA tissue samples and 53 adjacent normal tissue samples was detected using immunohistochemistry. The clinical role of UBE2C was analyzed...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29021233/divergent-activity-of-pseudogene-ptenp1-in-er-positive-and-negative-breast-cancer
#5
Synnøve Yndestad, Eilin Austreid, Kai Ove Skaftnesmo, Per Eystein Lønning, Hans P Eikesdal
Transcripts derived from the PTEN pseudogene (PTENP1) function as decoys to adsorb microRNAs (miRs) targeting the PTEN tumor suppressor for degradation, and PTENP1 upregulation is known to inhibit growth in preclinical cancer models. Here, PTENP1 3'UTR transduction influences PTEN, AKT/mTOR signaling, and tumor progression in estrogen receptor (ER)-positive and negative breast cancer cells. PTENP1 upregulation decreases PTEN gene expression in the ER-positive MCF7 and T47D human breast carcinoma cells and accelerates MCF7 tumor growth in vivo...
October 11, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29019331/clinical-and-pathological-characteristics-of-triple-positive-breast-cancer-among-iraqi-patients
#6
Nada A S Alwan, Faisal H Mualla, Munawar Al Naqash, Saad Kathum, Furat N Tawfiq, Sana Nadhir
BACKGROUND: Breast cancer is the most common malignancy affecting the Iraqi population and the leading cause of cancer related mortality among Iraqi women. It has been well documented that prognosis of patients depends largely upon the hormone receptor contents and HER-2 over expression of their neoplasm. Recent studies suggest that Triple Positive (TP) tumors, bearing the three markers, tend to exhibit a relatively favorable clinical behavior in which overtreatment is not recommended...
September 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29019086/family-history-influences-the-tumor-characteristics-and-prognosis-of-breast-cancers-developing-during-postmenopausal-hormone-therapy
#7
Rainer Fagerholm, Maria Faltinova, Kirsi Aaltonen, Kristiina Aittomäki, Päivi Heikkilä, Mervi Halttunen-Nieminen, Heli Nevanlinna, Carl Blomqvist
Long term use of postmenopausal hormone therapy (HT) has been reported to increase breast cancer risk. On the other hand, observational studies suggest that breast cancers diagnosed during HT may have a more favorable prognosis. While family history is a risk factor for breast cancer, and genetic factors also influence prognosis, the role of family history in combination with HT use has been little studied. We investigated the relationship between HT, family history, and prognosis in 584 (267 exposed) familial and 952 (460 exposed) non-familial breast cancer cases, using three survival end points: death from breast cancer (BCS), distant disease free survival (DDFS), and local recurrence free survival (LRFS)...
October 10, 2017: Familial Cancer
https://www.readbyqxmd.com/read/29018796/novel-carbonyl-analogs-of-tamoxifen-design-synthesis-and-biological-evaluation
#8
Konstantinos M Kasiotis, George Lambrinidis, Nikolas Fokialakis, Evangelia N Tzanetou, Emmanuel Mikros, Serkos A Haroutounian
Aim of this work was to provide tamoxifen analogs with enhanced estrogen receptor (ER) binding affinity. Hence, several derivatives were prepared using an efficient triarylethylenes synthetic protocol. The novel compounds bioactivity was evaluated through the determination of their receptor binding affinity and their agonist/antagonist activity against breast cancer tissue using a MCF-7 cell-based assay. Phenyl esters 6a,b and 8a,b exhibited binding affinity to both ERα and ERβ higher than 4-hydroxytamoxifen while compounds 13 and 14 have shown cellular antiestrogenic activity similar to 4-hydroxytamoxifen and the known ER inhibitor ICI182,780...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29016671/prognostic-and-clinicopathological-value-of-twist-expression-in-breast-cancer-a-meta-analysis
#9
Weiqiang Qiao, Zhiqiang Jia, Heyang Liu, Qipeng Liu, Ting Zhang, Wanying Guo, Peng Li, Miao Deng, Sanqiang Li
BACKGROUND: Despite initial indications that the transcription factor Twist could be used as a breast cancer prognostic marker, there still exists some controversy about its reliability. Thus, the aim of the present study was to assess the relationship between Twist expression and prognosis in breast carcinoma. MATERIALS AND METHODS: We identified eligible studies that reported an association between Twist expression and breast cancer prognosis by searching the literature in PubMed, Embase, the Cochrane Library, and Web of Science databases, through June 5, 2017...
2017: PloS One
https://www.readbyqxmd.com/read/28993797/the-linkage-between-breast-cancer-hypoxia-and-adipose-tissue
#10
REVIEW
Linda K Rausch, Nikolaus C Netzer, Josef Hoegel, Stephan Pramsohler
OBJECTIVE: The development of breast cancer cells is linked to hypoxia. The hypoxia-induced factor HIF-1α influences metastasis through neovascularization. Hypoxia seems to decrease the responsiveness to hormonal treatment due to loss of estrogen receptors (ERs). Obesity is discussed to increase hypoxia in adipocytes, which promotes a favorable environment for tumor cells in mammary fat tissue, whereas, tumor cells profit from good oxygen supply and are influenced by its deprivation as target regions within tumors show...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28993511/cell-cycle-dependent-tumor-engraftment-and-migration-are-enabled-by-aurora-a
#11
Tony L H Chu, Marisa Connell, Lixin Zhou, Zhengcheng He, Jennifer R Won, Seyed M Rahavi, Helen Chen, Pooja Mohan, Oksana Nemirovsky, Abbas Fotovati, Miguel Angel Pujana, Gregor Sd Reid, Torsten O Nielsen, Nelly Pante, Christopher A Maxwell
Cell cycle progression and the acquisition of a migratory phenotype are hallmarks of human carcinoma cells that are perceived as independent processes but may be interconnected by molecular pathways that control microtubule nucleation at centrosomes. Here, cell cycle progression dramatically impacts the engraftment kinetics of 4T1-luciferase2 breast cancer cells in immunocompetent BALB/c or immunocompromised NOD-SCID gamma (NSG) mice. Multi-parameter imaging of wound closure assays was used to track cell cycle progression, cell migration, and associated phenotypes in epithelial cells or carcinoma cells expressing a fluorescence ubiquitin cell cycle indicator...
October 9, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28986743/monosomy-17-in-potentially-curable-her2-amplified-breast-cancer-prognostic-and-predictive-impact
#12
David B Page, Hannah Wen, Edi Brogi, Dana Dure, Dara Ross, Kateri J Spinelli, Sujata Patil, Larry Norton, Clifford Hudis, Heather L McArthur
PURPOSE: HER2 copy number by fluorescence in situ hybridization (FISH) is typically reported relative to the centromere enumeration probe 17 (CEP17). HER2/CEP17 ratio could be impacted by alterations in the number of chromosome 17 copies. Monosomy of chromosome 17 (m17) is found in ~ 1900 cases of early-stage HER2-positive breast cancer annually in the United States; however, the efficacy of HER2-directed trastuzumab therapy in these patients is not well characterized. Here, we retrospectively identified HER2-amplified, stage I-III breast cancers with m17 and characterized the impact of trastuzumab treatment...
October 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28986287/deciphering-the-molecular-mechanism-underlying-anticancer-activity-of-coumestrol-in-triple-negative-breast-cancer-cells
#13
Atif Zafar, Swarnendra Singh, Yatendra Kumar Satija, Daman Saluja, Imrana Naseem
Triple-negative breast cancer (TNBC) represents the highly aggressive subgroup of breast cancers with poor prognosis due to absence of estrogen receptor (ER). Therefore, alternative targeted therapies are required against ER-negative breast cancers. Coumestrol, a phytoestrogen inhibits cell growth of ER-negative breast cancer MDA-MB-231 cells; the exact mechanism has not yet been reported. Unlike normal cells, cancer cells contain elevated copper which play an integral role in angiogenesis. The current focus of the work was to identify any possible role of copper in coumestrol cytotoxic action against breast cancer MDA-MB-231 cells...
October 3, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28985473/red-clover-aryl-hydrocarbon-receptor-ahr-and-estrogen-receptor-er-agonists-enhance-genotoxic-estrogen-metabolism
#14
Tareisha L Dunlap, Caitlin E Howell, Nita Mukand, Shao-Nong Chen, Guido F Pauli, Birgit Maria Dietz, Judy L Bolton
Many women consider botanical dietary supplements (BDSs) as safe alternatives to hormone therapy for menopausal symptoms. However, the effect of BDSs on breast cancer risk is largely unknown. In the estrogen chemical carcinogenesis pathway, P450 1B1 metabolizes estrogens to 4-hydroxylated catechols, which are oxidized to genotoxic quinones that initiate and promote breast cancer. In contrast, P450 1A1 catalyzed 2-hydroxylation represents a detoxification pathway. The current study evaluated the effects of red clover, a popular BDS used for women's health, and its isoflavones, biochanin A (BA), formononetin (FN), genistein (GN), and daidzein (DZ), on estrogen metabolism...
October 6, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28985022/endocrine-sensitivity-of-estrogen-receptor-positive-breast-cancer-is-negatively-correlated-with-aspartate-%C3%AE-hydroxylase-expression
#15
Masafumi Shimoda, Ami Hori, Jack R Wands, Ryo Tsunashima, Yasuto Naoi, Tomohiro Miyake, Tomonori Tanei, Naofumi Kagara, Kenzo Shimazu, Seung Jin Kim, Shinzaburo Noguchi
Although prognostic markers for early estrogen receptor (ER)-positive breast cancer have been extensively developed, predictive markers for adjuvant endocrine therapy are still lacking. Focusing on the mechanisms underlying endocrine resistance, we investigated whether the endocrine sensitivity of ER-positive breast cancer cells was correlated with the expression of aspartate-β-hydroxylase (ASPH), which is involved in the development of hepatocellular carcinoma. ASPH expression in ER-positive and tamoxifen-resistant breast cancer cells was upregulated by the MAPK and phosphoinositide-3 kinase (PI3K) pathways, which both play pivotal roles in endocrine resistance...
October 6, 2017: Cancer Science
https://www.readbyqxmd.com/read/28984771/application-of-neoadjuvant-chemotherapy-in-occult-breast-cancer-five-case-reports
#16
Haisong Yang, Ling Li, Mengmeng Zhang, Shiyong Zhang, Shu Xu, Xiaoxia Ma
RATIONALE: Although rare, occult breast cancer (OBC) originates from breast tissue. Its primary lesions cannot be identified by clinical examination or imaging; therefore, the diagnosis, treatment, and prognosis remain controversial. PATIENT CONCERNS: This study comprised 5 female OBC patients who were admitted to the Affiliated Hospital of Guizhou Medical University for painless axillary lumps. DIAGNOSES: F-flurodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) indicated metastasis in the ipsilateral axillary lymph nodes...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28984209/genome-wide-identification-of-key-modulators-of-gene-gene-interaction-networks-in-breast-cancer
#17
Yu-Chiao Chiu, Li-Ju Wang, Tzu-Hung Hsiao, Eric Y Chuang, Yidong Chen
BACKGROUND: With the advances in high-throughput gene profiling technologies, a large volume of gene interaction maps has been constructed. A higher-level layer of gene-gene interaction, namely modulate gene interaction, is composed of gene pairs of which interaction strengths are modulated by (i.e., dependent on) the expression level of a key modulator gene. Systematic investigations into the modulation by estrogen receptor (ER), the best-known modulator gene, have revealed the functional and prognostic significance in breast cancer...
October 3, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28982874/impact-of-calgb-9343-trial-and-sociodemographic-variation-on-patterns-of-adjuvant-radiation-therapy-practice-for-elderly-women-%C3%A2-70-years-with-stage-i-estrogen-receptor-positive-breast-cancer-analysis-of-the-national-cancer-data-base
#18
Quyen D Chu, Meijiao Zhou, Kaelen L Medeiros, Prakash Peddi, Xiao Cheng Wu
BACKGROUND: The Cancer and Leukemia Group B (CALGB) 9343 trial demonstrated that adjuvant radiation therapy (RT) can be omitted in women 70 years or older, with small (≤2 cm), negative lymph nodes, estrogen receptor (ER)-positive breast cancer. We examined whether RT usage following the CALGB publication had decreased over time and evaluated sociodemographic and clinical factors associated with RT omission. MATERIALS AND METHODS: From the National Cancer Data Base, we analyzed a cohort of 120,308 women aged 70 years or older with stage I, ER-positive breast cancer who underwent lumpectomy...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28982858/effects-of-s1p1-and-s1p3-in-er-and-er-breast-cancer-cells
#19
Ibrahim Ugur Calis, Didem Turgut Cosan, Fezan Mutlu
BACKGROUND/AIM: In this study, sphingosine-1-phosphate receptor-1 (S1P1) and S1P3 receptors were silenced to evaluate proliferation, adhesion, viability and lateral motility in estrogen receptor-negative MCF-7 and estrogen receptor-positive MDA-MB-231 breast cancer cells. MATERIALS AND METHODS: Groups of MCF-7 and MDA-MB-231 cells with: no small interfering RNA (siRNA); siRNA with no target; S1P1-silencing siRNA; S1P3-silencing siRNA; and siRNAs silencing both S1P1, and S1P3 were examined for this purpose at 24, 48 and 72 h after intervention...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28982841/adjuvant-endocrine-therapy-for-hormone-positive-breast-cancer-focusing-on-ovarian-suppression-and-extended-treatment-an-update
#20
REVIEW
Daniel Glassman, Sue Hignett, Shazza Rehman, Richard Linforth, Mohamed Salhab
The benefits of five years of adjuvant endocrine therapy for oestrogen receptor (ER)-positive early breast cancer are well established. However, recent evidence suggests that extended endocrine treatment and ovarian suppression in selected groups of patients have significant advantages. In this article, we review the current evidence for adjuvant endocrine therapy in breast cancer with focus on extended adjuvant endocrine therapy and ovarian suppression, and also highlight the advantages and disadvantages of these therapeutic strategies...
October 2017: Anticancer Research
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