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https://www.readbyqxmd.com/read/29932226/effects-of-rna-interference-mediated-silencing-of-toll-like-receptor-4-gene-on-proliferation-and-apoptosis-of-human-breast-cancer-mcf-7-and-mda-mb-231-cells-an-in-vitro-study
#1
Xiao-Ling Gao, Jiao-Jiao Yang, Shu-Juan Wang, Yan Chen, Bei Wang, Er-Jing Cheng, Jian-Nan Gong, Yan-Ting Dong, Dai Liu, Xiang-Li Wang, Ya-Qiong Huang, Dong-Dong An
Breast cancer is known as the most prevalent cancer in women worldwide, and has an undeniable negative impact on public health, both physically, and mentally. This study aims to investigate the effects of toll-like receptor 4 (TLR4) gene silencing on proliferation and apoptosis of human breast cancer cells to explore for a new theoretical basis for its treatment. TLR4 small interference RNA (siRNA) fragment recombinant plasmids were constructed, including TLR4 siRNA-1, TLR4 siRNA-2, and TLR4 siRNA-3. Human breast cancer MCF-7 and MDA-MB-231 cells were assigned into blank, negative control (NC), TLR4 siRNA-1, TLR4 siRNA-2, and TLR4 siRNA-3 groups...
June 22, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29932151/sirnas-targeting-growth-factor-receptor-and-anti-apoptotic-genes-synergistically-kill-breast-cancer-cells-through-inhibition-of-mapk-and-pi-3-kinase-pathways
#2
Nur Izyani Kamaruzman, Snigdha Tiash, Maeirah Ashaie, Ezharul Hoque Chowdhury
Breast cancer, the second leading cause of female deaths worldwide, is usually treated with cytotoxic drugs, accompanied by adverse side-effects, development of chemoresistance and relapse of disease condition. Survival and proliferation of the cancer cells are greatly empowered by over-expression or over-activation of growth factor receptors and anti-apoptotic factors. Identification of these key players that cross-talk to each other, and subsequently, knockdown with their respective siRNAs in a synchronous manner could be a promising approach to precisely treat the cancer...
June 22, 2018: Biomedicines
https://www.readbyqxmd.com/read/29931061/successful-targeted-therapies-for-breast-cancer-the-worcester-foundation-and-future-opportunities-in-women-s-health
#3
Balkees Abderrahman, V Craig Jordan
The signing of the National Cancer Act in 1971, was designed to take laboratory discoveries rapidly from the bench to the bedside. A "war on cancer" had been declared. Combination cytotoxic chemotherapy was predicted to cure all cancers based on the stunning success in treating childhood leukemia. Breast cancer treatments were primitive; radical mastectomy and radiation was standard of care for disease that had not spread. Ablative endocrine surgery (oophorectomy, hypophysectomy, and adrenalectomy) was a palliative last option for metastatic breast cancer...
June 19, 2018: Endocrinology
https://www.readbyqxmd.com/read/29930291/adipocytes-induce-distinct-gene-expression-profiles-in-mammary-tumor-cells-and-enhance-inflammatory-signaling-in-invasive-breast-cancer-cells
#4
Annina Nickel, Christina Blücher, Omaeir Al Kadri, Nancy Schwagarus, Silvana Müller, Michael Schaab, Joachim Thiery, Ralph Burkhardt, Sonja C Stadler
Obesity is a known risk factor for breast cancer. Since obesity rates are constantly rising worldwide, understanding the molecular details of the interaction between adipose tissue and breast tumors becomes an urgent task. To investigate potential molecular changes in breast cancer cells induced by co-existing adipocytes, we used a co-culture system of different breast cancer cell lines (MCF-7 and T47D: ER+ /PR+ /HER2- and MDA-MB-231: ER- /PR- /HER2- ) and murine 3T3-L1 adipocytes. Here, we report that co-culture with adipocytes revealed distinct changes in global gene expression pattern in the different breast cancer cell lines...
June 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29928444/expression-signature-of-ten-genes-predicts-the-survival-of-patients-with-estrogen-receptor-positive-breast-cancer-that-were-treated-with-tamoxifen
#5
He Huang, Qiyu Chen, Weijian Sun, Mingdong Lu, Yaojun Yu, Zhiqiang Zheng, Pihong Li
Although tamoxifen is the most frequently used drug for the treatment of estrogen receptor positive (ER+ )-breast cancer (BRCA), its efficacy varies between patients. In the present study, Cox multivariate regression of the relative mRNA expression levels in two microarray-based datasets (GSE17005 and GSE26971) was employed to develop a risk score model to evaluate the outcome of patients with BRCA in the GSE17005 dataset. A total of ten genes were used to develop the prediction model for the survival of tamoxifen-treated patients with breast cancer...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928427/overexpression-of-cxxc5-is-a-strong-poor-prognostic-factor-in-er-breast-cancer
#6
Lei Fang, Yu Wang, Yang Gao, Xuejun Chen
CXXC5 is a newly identified CXXC-type zinc finger family protein, which is encoded by the CXXC5 gene localised to the 5q31.3 chromosomal region. Previous studies revealed that CXXC5 is associated with various malignant tumours. The aim of the present study was to investigate the prognosis prediction of CXXC5 in different breast cancer subtypes via the Gene Expression Omnibus database and bc-GenExMiner. CXXC5 overexpression was observed as associated with a poor prognosis for oestrogen receptor positive (ER+) breast cancer...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928262/coffee-is-associated-with-lower-breast-tumor-insulin-like-growth-factor-receptor-1-levels-in-normal-weight-patients-and-improved-prognosis-following-tamoxifen-or-radiotherapy-treatment
#7
Sofie Björner, Ann H Rosendahl, Helga Tryggvadottir, Maria Simonsson, Karin Jirström, Signe Borgquist, Carsten Rose, Christian Ingvar, Helena Jernström
Coffee is associated with decreased breast cancer risk, but the impact of body mass index (BMI) in combination with coffee consumption on prognosis is unclear. The suppressive effect of coffee constituents on the insulin-like growth factor receptor 1 (IGF1R) levels in breast cancer cells may play a role. The aim was to investigate the prognostic impact of coffee consumption and possible associations with tumor-specific IGF1R protein expression and BMI in a population-based cohort in Sweden, comprising 1,014 primary breast cancer patients without pretreatment enrolled 2002-2012 and followed for up to 13 years...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29927112/generating-conformation-specific-polyclonal-and-monoclonal-anti-protein-kinase-c-antibodies-and-anti-active-state-specific-pkc-antibodies
#8
Darlene A Pena, Denise M V Pacheco, Paulo S L Oliveira, Maria J M Alves, Deborah Schechtman
The protein kinase C (PKC) family of serine/ threonine kinases has been shown to play active roles as either suppressors or promoters of carcinogenesis in different types of tumors. Using antibodies that preferentially recognize the active conformation of classical PKCs (cPKCs), we have previously shown that in breast cancer samples the expression levels of cPKCs were similar in estrogen receptor-positive (ER+ ) as compared to triple-negative tumors; however, the levels of active cPKCs were different. Determining the activation status of PKCs and other kinases in tumors may thus aid therapeutic decisions...
June 2018: Current Protocols in Chemical Biology
https://www.readbyqxmd.com/read/29926297/breast-cancer-in-women-with-neurofibromatosis-type-1-nf1-a-comprehensive-case-series-with-molecular-insights-into-its-aggressive-phenotype
#9
Yoon-Sim Yap, Prabhakaran Munusamy, Cindy Lim, Claire H T Chan, Aldo Prawira, Sau-Yeen Loke, Swee-Ho Lim, Kong-Wee Ong, Wei-Sean Yong, Sarah B H Ng, Iain B H Tan, David F Callen, Jeffrey C T Lim, Aye-Aye Thike, Puay-Hoon Tan, Ann S G Lee
PURPOSE: The purpose of the study was to improve the understanding of NF1-associated breast cancer, given the increased risk of breast cancer in this tumour predisposition syndrome and the limited data. METHODS: We identified 18 women with NF1 and breast cancer at our institution. Clinical and pathologic characteristics of NF1-associated breast cancers were compared with 7132 breast cancers in patients without NF1 from our institutional database. Next generation sequencing was performed on DNA from blood and breast cancer specimens available...
June 21, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29925919/oncoprotein-hbxip-induces-pkm2-via-transcription-factor-e2f1-to-promote-cell-proliferation-in-er-positive-breast-cancer
#10
Bo-Wen Liu, Tian-Jiao Wang, Lei-Lei Li, Lu Zhang, Yun-Xia Liu, Jin-Yan Feng, Yue Wu, Fei-Fei Xu, Quan-Sheng Zhang, Ming-Zhu Bao, Wei-Ying Zhang, Li-Hong Ye
We have reported that hepatitis B X-interacting protein (HBXIP, also termed LAMTOR5) can act as an oncogenic transcriptional co-activator to modulate gene expression, promoting breast cancer development. Pyruvate kinase muscle isozyme M2 (PKM2), encoded by PKM gene, has emerged as a key oncoprotein in breast cancer. Yet, the regulatory mechanism of PKM2 is still unexplored. Here, we report that HBXIP can upregulate PKM2 to accelerate proliferation of estrogen receptor positive (ER+) breast cancer. Immunohistochemistry analysis using breast cancer tissue microarray uncovered a positive association between the expression of HBXIP and PKM2...
June 20, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29925812/crosstalk-between-er%C3%AE-and-receptor-tyrosine-kinase-signalling-and-implications-for-the-development-of-anti-endocrine-resistance
#11
Rugaia Z Montaser, Helen M Coley
Although anti-endocrine therapies have significantly advanced the treatment of breast cancer, they pose the problem of acquired drug resistance. The oestrogen receptor (ER)-expressing breast cancer cell lines MCF-7 and T47D alongside their in vitro derived resistant counterparts MCF-7-TR (tamoxifen-resistant) and T47D-FR (fulvestrant-resistant) showed dual resistance to fulvestrant and tamoxifen in the presence of upregulated HER1 and HER2 growth factor receptors. Our study demonstrated that tamoxifen resistance and fulvestrant resistance are associated with collateral sensitivity to the tyrosine kinase inhibitors (TKIs) lapatinib ( p < 0...
June 20, 2018: Cancers
https://www.readbyqxmd.com/read/29924962/prognostic-value-of-aldehyde-dehydrogenase-1-aldh1-in-invasive-breast-carcinomas
#12
Hale Demir, Ozgecan Dulgar, Bugra Taygun Gulle, Hande Turna, Sennur Ilvan
Aldehyde dehydrogenase 1 (ALDH1) has been identified as a marker of cancer stem cells in breast cancer (BC). Recent studies showed that ALDH1 expression is correlated with poor prognostic parameters and worse clinical outcome in BC. We evaluated ALDH1 expression by immunohistochemistry in a series of 217 invasive BCs and investigated the correlation between ALDH1 expression and clinicopathological parameters, molecular subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 [HER2] type, and triple-negative BC [TNBC]), and patient survival...
June 11, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29923341/organochlorine-pesticide-residues-in-human-breast-tissue-and-their-relationships-with-clinical-and-pathological-characteristics-of-breast-cancer
#13
Rachel E Ellsworth, Paul J Kostyniak, Lai-Har Chi, Craig D Shriver, Nicholas S Costantino, Darrell L Ellsworth
Agricultural pesticides are abundant environmental contaminants worldwide, prompting interest in studying their possible detrimental health effects. We examined organochlorine residues by quadrant (n = 245) in breast adipose tissues from 51 women with various stages of breast health to determine patterns of bioaccumulation within the breast and to assess relationships with patient clinical characteristics. Three organochlorine residues-2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE), hexachlorobenzene (HCB), and mirex-assayed by high resolution gas chromatography were abundant in breast tissue...
June 19, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29922922/metabolic-relevance-for-n-hydroxy-l-arginine-reduction-in-estrogen-negative-breast-cancer-cells
#14
Srinidi Mohan, Seema Patel, Ian Greenstein, Cathy Ng, Kelly Frazier, Giang Nguyen, Lisa Harding, David Barlow
We had shown Nw -hydroxy-L-arginine (NOHA) as a promising blood-based biomarker for estrogen-receptor-negative (ER - ) breast cancer (BC) that differentiates ER - BC based on grade and molecular phenotype. In this in vitro study, we assessed the metabolic relevance for ER- BC-specific NOHA modulation and correlated them with NOHA regulatory responses. This study aids future NOHA clinical utility in ER- BC diagnosis and therapy management and would prove useful for potential drug discovery and development process...
June 20, 2018: Amino Acids
https://www.readbyqxmd.com/read/29922160/decost-a-new-approach-in-drug-repurposing-from-control-system-theory
#15
Thanh M Nguyen, Syed A Muhammad, Sara Ibrahim, Lin Ma, Jinlei Guo, Baogang Bai, Bixin Zeng
In this paper, we propose DeCoST (Drug Repurposing from Control System Theory) framework to apply control system paradigm for drug repurposing purpose. Drug repurposing has become one of the most active areas in pharmacology since the last decade. Compared to traditional drug development, drug repurposing may provide more systematic and significantly less expensive approaches in discovering new treatments for complex diseases. Although drug repurposing techniques rapidly evolve from "one: disease-gene-drug" to "multi: gene, dru" and from "lazy guilt-by-association" to "systematic model-based pattern matching," mathematical system and control paradigm has not been widely applied to model the system biology connectivity among drugs, genes, and diseases...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29921827/differential-expression-and-pathway-analysis-in-drug-resistant-triple-negative-breast-cancer-cell-lines-using-rnaseq-analysis
#16
Safa Shaheen, Febin Fawaz, Shaheen Shah, Dietrich Büsselberg
Triple-negative breast cancer (TNBC) is among the most notorious types of breast cancer, the treatment of which does not give consistent results due to the absence of the three receptors (estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) as well as high amount of molecular variability. Drug resistance also contributes to treatment unresponsiveness. We studied differentially expressed genes, their biological roles, as well as pathways from RNA-Seq datasets of two different TNBC drug-resistant cell lines of Basal B subtype SUM159 and MDA-MB-231 treated with drugs JQ1 and Dexamethasone, respectively, to elucidate the mechanism of drug resistance...
June 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29921729/integrating-radiosensitivity-and-immune-gene-signatures-for-predicting-benefit-of-radiotherapy-in-breast-cancer
#17
Yi Cui, Bailiang Li, Erqi Liu Pollom, Kathleen Horst, Ruijiang Li
PURPOSE: Breast cancer is a heterogeneous disease and not all patients respond equally to adjuvant radiotherapy. Predictive biomarkers are needed to select patients who will benefit from the treatment and spare others the toxicity and burden of radiation. EXPERIMENTAL DESIGN: We first trained and tested an intrinsic radiosensitivity gene signature to predict local recurrence after radiotherapy in three cohorts of 948 patients. Next, we developed an antigen processing and presentation-based immune signature by maximizing the treatment interaction effect in 129 patients...
June 19, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29921289/snai2-upregulation-is-associated-with-an-aggressive-phenotype-in-fulvestrant-resistant-breast-cancer-cells-and-is-an-indicator-of-poor-response-to-endocrine-therapy-in-estrogen-receptor-positive-metastatic-breast-cancer
#18
Carla L Alves, Daniel Elias, Maria B Lyng, Martin Bak, Henrik J Ditzel
BACKGROUND: Endocrine resistance in estrogen receptor-positive (ER+) breast cancer is a major clinical problem and is associated with accelerated cancer cell growth, increased motility and acquisition of mesenchymal characteristics. However, the specific molecules and pathways involved in these altered features remain to be detailed, and may be promising therapeutic targets to overcome endocrine resistance. METHODS: In the present study, we evaluated altered expression of epithelial-mesenchymal transition (EMT) regulators in ER+ breast cancer cell models of tamoxifen or fulvestrant resistance, by gene expression profiling...
June 19, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29917140/predictive-biomarkers-for-endocrine-therapy-retrospective-study-in-tamoxifen-and-exemestane-adjuvant-multinational-team-trial
#19
Antonia K Roseweir, Lindsay Bennett, Ashley Dickson, Kelvin Cheng, Mary-Anne Quintayo, Jane Bayani, Donald C McMillan, Paul G Horgan, Cornelis J H van de Velde, Caroline Seynaeve, Annette Hasenburg, Dirk G Kieback, Christos Markopoulos, Luc Y Dirix, Daniel W Rea, Elizabeth A Mallon, John M S Bartlett, Joanne Edwards
Background: Aromatase inhibitors improve disease-free survival compared with tamoxifen in postmenopausal women with hormone receptor-positive breast cancer. The Tamoxifen and Exemestane Adjuvant Multinational (TEAM) trial compared exemestane monotherapy with sequential therapy of tamoxifen followed by exemestane. The trial failed to show a statistically significant difference between treatment arms. A robust translational program was established to investigate predictive biomarkers. Methods: A tissue microarray was retrospectively constructed using a subset of patient tissues (n = 4631) from the TEAM trial (n = 9766)...
June 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29915948/thyroid-hormone-receptor-beta-1-expression-in-early-breast-cancer-a-validation-study
#20
K J Jerzak, J G Cockburn, S K Dhesy-Thind, G R Pond, K I Pritchard, S Nofech-Mozes, P Sun, S A Narod, A Bane
PURPOSE: Preliminary data suggest that high expression of the TRβ1 tumor suppressor is associated with longer survival among women with early breast cancer. We undertook this study to validate these findings. METHODS: In this prospective cohort study, we analyzed the prognostic significance of TRβ1 protein expression in the breast tumors of 796 women who had undergone breast surgery in the Henrietta Banting Breast Cancer database. All women were recruited after undergoing primary surgical therapy at Women's College Hospital (Toronto, ON, Canada) between January 1987 and December 2000...
June 18, 2018: Breast Cancer Research and Treatment
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