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https://www.readbyqxmd.com/read/28209094/attenuation-of-arsenic-trioxide-induced-cardiotoxicity-through-flaxseed-oil-in-experimental-rats
#1
Mathews V Varghese, M Abhilash, Manju Alex, M V Sauganth Paul, A Prathapan, K G Raghu, R Harikumaran Nair
OBJECTIVES: Arsenic trioxide (As2O3) is a potent drug for acute promyelocytic leukaemia, but its clinical trials are allied with some serious adverse events mainly cardiac functional abnormalities. So the objective of our investigation is to identify the cardioprotective action of flaxseed oil (FSO), a natural compound against As2O3 induced cardiotoxicity. METHODS: Male wistar rats were treated with As2O3 (4 mg/kg) to induce cardiotoxicity. FSO (250 and 500 mg/kg) was given in combination with As2O3 for evaluating its cardioprotective efficacy...
February 17, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28188923/arsenic-sulfide-induces-apoptosis-and-autophagy-through-the-activation-of-ros-jnk-and-suppression-of-akt-mtor-signaling-pathways-in-osteosarcoma
#2
Gangyang Wang, Tao Zhang, Wei Sun, Hongsheng Wang, Fei Yin, Zhuoying Wang, Dongqing Zuo, Mengxiong Sun, Zifei Zhou, Binhui Lin, Jing Xu, Yingqi Hua, Haoqing Li, Zhengdong Cai
Osteosarcoma is a common primary malignant bone tumor, the cure rate of which has stagnated over the past 25-30 years. Arsenic sulfide (As2S2), the main active ingredient of the traditional Chinese medicine realgar, has been proved to have antitumor efficacy in several tumor types including acute promyelocytic leukemia, gastric cancer and colon cancer. Here, we investigated the efficacy and mechanism of As2S2 in osteosarcoma both in vitro and in vivo. In this study, we demonstrated that As2S2 potently suppressed cell proliferation by inducing G2/M phase arrest in various osteosarcoma cell lines...
February 7, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28187727/cryptotanshinone-enhances-the-effect-of-arsenic-trioxide-in-treating-liver-cancer-cell-by-inducing-apoptosis-through-downregulating-phosphorylated-stat3-in-vitro-and-in-vivo
#3
Li Shen, Guangshun Zhang, Zhaohuan Lou, Guanhua Xu, Guangji Zhang
BACKGROUND: Arsenic trioxide (ATO) is approved for treating terminal-stage liver cancer in China. Cryptotanshinone (CT), a STAT3 inhibitor, has exhibited certain anti-tumor potency; however, the use of CT enhanced ATO for treating liver cancer has not been reported. Here we try to elucidate how CT could enhance the efficacy of ATO for treating liver cancer and its correlation to STAT3 in vitro and in vivo. METHODS: Cell viability of ATO combined with CT was assessed by (1)MTT assay...
February 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28179585/oncogenomic-disruptions-in-arsenic-induced-carcinogenesis
#4
REVIEW
Adam P Sage, Brenda C Minatel, Kevin W Ng, Greg L Stewart, Trevor J B Dummer, Wan L Lam, Victor D Martinez
Chronic exposure to arsenic affects more than 200 million people worldwide, and has been associated with many adverse health effects, including cancer in several organs. There is accumulating evidence that arsenic biotransformation, a step in the elimination of arsenic from the human body, can induce changes at a genetic and epigenetic level, leading to carcinogenesis. At the genetic level, arsenic interferes with key cellular processes such as DNA damage-repair and chromosomal structure, leading to genomic instability...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28176197/using-urine-as-a-biomarker-in-human-exposure-risk-associated-with-arsenic-and-other-heavy-metals-contaminating-drinking-groundwater-in-intensively-agricultural-areas-of-thailand
#5
Pokkate Wongsasuluk, Srilert Chotpantarat, Wattasit Siriwong, Mark Robson
Urine used as a biomarker was collected and compared between two groups of participants: (1) a groundwater-drinking group and (2) a non-groundwater-drinking group in intensively agricultural areas in Ubon Ratchathani province, Thailand. The statistical relationship with the metal concentration in shallow groundwater wells was established with urine data. According to the groundwater data, the health risk assessment results for four metals appeared to be higher for participants who drank groundwater than for the other group...
February 7, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28160532/air-pollution-and-potential-health-risk-in-ostrava-region-a-review
#6
Vítězslav Jiřík, Ondřej Machaczka, Hana Miturová, Ivan Tomášek, Hana Šlachtová, Jana Janoutová, Helena Velická, Vladimír Janout
AIM: The aim of this review was to collect all available data about air pollution in Ostrava, which is one of the most polluted area in central Europe and to make a concise assessment of health risks resulting from historical exposures of air pollutants since the beginning of the monitoring, i.e. since 1970 to the present time. METHODS: All available information sources (the Czech Hydrometeorological Institute, the Institute of Public Health in Ostrava or publications) were used...
December 2016: Central European Journal of Public Health
https://www.readbyqxmd.com/read/28157645/low-level-arsenic-in-drinking-water-and-risk-of-incident-myocardial-infarction-a-cohort-study
#7
Maria Monrad, Annette Kjær Ersbøll, Mette Sørensen, Rikke Baastrup, Birgitte Hansen, Anders Gammelmark, Anne Tjønneland, Kim Overvad, Ole Raaschou-Nielsen
BACKGROUND: Epidemiological studies have shown that intake of drinking water with high levels of arsenic (>100μg/L) is associated with risk for cardiovascular diseases, but studies on lower levels of arsenic show inconsistent results. OBJECTIVE: The aim of this study was to investigate the relationship between exposure to low level arsenic in drinking water and risk of myocardial infarction in Denmark. METHODS: From the Danish Diet, Cancer and Health cohort of 57,053 people aged 50-64 years at enrolment in 1993-1997, we identified 2707 cases of incident myocardial infarction from enrolment to end of follow-up in February 2012...
January 31, 2017: Environmental Research
https://www.readbyqxmd.com/read/28154361/research-on-hygiene-based-on-fieldwork-and-experimental-studies
#8
Ichiro Yajima
Several experimental studies on hygiene have recently been performed and fieldwork studies are also important and essential tools. However, the implementation of experimental studies is insufficient compared with that of fieldwork studies on hygiene. Here, we show our well-balanced implementation of both fieldwork and experimental studies of toxic-element-mediated diseases including skin cancer and hearing loss. Since the pollution of drinking well water by toxic elements induces various diseases including skin cancer, we performed both fieldwork and experimental studies to determine the levels of toxic elements and the mechanisms behind the development of toxic-element-related diseases and to develop a novel remediation system...
2017: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/28140569/silac-based-quantitative-proteomic-analysis-unveiled-the-arsenite-induced-perturbation-of-multiple-pathways-in-human-skin-fibroblast-cells
#9
Fan Zhang, Yongsheng Xiao, Yinsheng Wang
Humans are exposed to arsenic species through inhalation, ingestion and dermal contact, which may lead to skin, liver, and bladder cancers as well as cardiovascular and neurological diseases. The mechanisms underlying the cytotoxic and carcinogenic effects of arsenic species, however, remain incompletely understood. To exploit the mechanisms of toxicity of As(III), we employed stable isotope labeling by amino acids in cell culture (SILAC) together with LC-MS/MS analysis to assess quantitatively the As(III)-induced perturbation of the entire proteome of cultured human skin fibroblast cells...
January 31, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28125038/arsenic-induces-p62-expression-to-form-a-positive-feedback-loop-with-nrf2-in-human-epidermal-keratinocytes-implications-for-preventing-arsenic-induced-skin-cancer
#10
Palak Shah, Elaine Trinh, Lei Qiang, Lishi Xie, Wen-Yang Hu, Gail S Prins, Jingbo Pi, Yu-Ying He
Exposure to inorganic arsenic in contaminated drinking water poses an environmental public health threat for hundreds of millions of people in the US and around the world. Arsenic is a known carcinogen for skin cancer. However, the mechanism by which arsenic induces skin cancer remains poorly understood. Here, we have shown that arsenic induces p62 expression in an autophagy-independent manner in human HaCaT keratinocytes. In mouse skin, chronic arsenic exposure through drinking water increases p62 protein levels in the epidermis...
January 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28110321/recent-advances-in-arsenic-trioxide-encapsulated-nanoparticles-as-drug-delivery-agents-to-solid-cancers
#11
Akhtar Anam, Wang Scarlet Xiaoyan, Ghali Lucy, Bell Celia, Wen Xuesong
Since arsenic trioxide was first approved as the front line therapy for acute promyelocytic leukemia 25 years ago, its anti-cancer properties for various malignancies have been under intense investigation. However, the clinical successes of arsenic trioxide in treating hematological cancers have not been translated to solid cancers. This is due to arsenic's rapid clearance by the body's immune system before reaching the tumor site. Several attempts have henceforth been made to increase its bioavailability toward solid cancers without increasing its dosage albeit without much success...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28108741/metabolism-toxicity-and-anticancer-activities-of-arsenic-compounds
#12
Islam Khairul, Qian Qian Wang, Yu Han Jiang, Chao Wang, Hua Naranmandura
A variety of studies indicated that inorganic arsenic and its methylated metabolites have paradoxical effects, namely, carcinogenic and anticancer effects. Epidemiological studies have shown that long term exposure to arsenic can increase the risk of cancers of lung, skin or bladder in man, which is probably associated with the arsenic metabolism. In fact, the enzymatic conversion of inorganic arsenic by Arsenic (+3 oxidation state) methyltransferase (AS3MT) to mono- and dimethylated arsenic species has long been considered as a major route for detoxification...
January 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28098817/spatial-analysis-of-human-health-risk-due-to-arsenic-exposure-through-drinking-groundwater-in-taiwan-s-pingtung-plain
#13
Ching-Ping Liang, Yi-Chi Chien, Cheng-Shin Jang, Ching-Fang Chen, Jui-Sheng Chen
Chronic arsenic (As) exposure continues to be a public health problem of major concern worldwide, affecting hundreds of millions of people. A long-term groundwater quality survey has revealed that 20% of the groundwater in southern Taiwan's Pingtung Plain is clearly contaminated with a measured As concentration in excess of the maximum level of 10 µg/L recommended by the World Health Organization. The situation is further complicated by the fact that more than half of the inhabitants in this area continue to use groundwater for drinking...
January 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28092839/effect-and-mechanism-of-sorbus-pohuashanensis-hante-hedl-flavonoids-protect-against-arsenic-trioxide-induced-cardiotoxicity
#14
Xiaojin Yu, Zhenyu Wang, Zunpeng Shu, Zhengqing Li, Yuan Ning, Keli Yun, Haina Bai, Ruihai Liu, Wenli Liu
The cardiotoxicity of arsenic trioxide (ATO) limits its clinical application in cancer treatment. Evidences suggest that sorbus has antioxidant activity and its consumption has been linked with improved cardioprotection. In this study, we investigated the cardio-protective effect and mechanisms of Sorbus pohuashanensis (Hante) Hedl. flavonoids (SPF) against ATO in BALB/c mice and H9c2 cells. Eleven major flavonoids were confirmed by ultra-performance liquid chromatography electrospray ionization quadrupole time of flight mass spectrometry (UPLC-ESI-Q-TOF-MS)...
January 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28071820/response-profiling-using-shotgun-proteomics-enables-global-metallodrug-mechanisms-of-action-to-be-established
#15
Dominique Kreutz, Andrea Bileck, Kerstin Plessl, Denise Wolrab, Michael Groessl, Bernhard K Keppler, Samuel M Meier, Christopher Gerner
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, has been applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic trioxide was observed by protein regulations in SW480, but not HCT116 cells. Comparing the basal protein expression in the two cell lines revealed an 80 % convergence of protein identification, but with significant expression differences, which in turn seem to affect the extent of protein regulation...
November 7, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28069514/increased-microrna-21-expression-contributes-to-arsenic-induced-skin-lesions-skin-cancers-and-respiratory-distress-in-chronically-exposed-individuals
#16
Nilanjana Banerjee, Apurba K Bandyopadhyay, Suman Dutta, Jayanta K Das, Tarit Roy Chowdhury, Arun Bandyopadhyay, Ashok K Giri
More than 26 million people in West Bengal, India, are exposed to arsenic through drinking water, leading to several deleterious endpoints including precancerous and cancerous skin lesions and other non-dermatological health effects. Here, our aim was to identify whether miR21 is associated with such dermatological and non-dermatological health outcomes in chronically exposed humans. A total of 123 subjects from West Bengal were recruited for this study (45 exposed individuals with skin lesions, 38 exposed individuals without skin lesions and 40 unexposed individuals)...
January 6, 2017: Toxicology
https://www.readbyqxmd.com/read/28065543/mitigating-dietary-arsenic-exposure-current-status-in-the-united-states-and-recommendations-for-an-improved-path-forward
#17
Keeve E Nachman, Gary L Ginsberg, Mark D Miller, Carolyn J Murray, Anne E Nigra, Claire B Pendergrast
Inorganic arsenic (iAs) is a well-characterized carcinogen, and recent epidemiologic studies have linked chronic exposures to non-cancer health outcomes, including cardiovascular disease, diabetes, skin lesions and respiratory disorders. Greater vulnerability has been demonstrated with early life exposure for health effects including lung and bladder cancer, immunotoxicity and neurodevelopment. Despite its well-known toxicity, there are important gaps in the regulatory oversight of iAs in food and in risk communication...
March 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28061438/combination-of-arsenic-trioxide-and-everolimus-rad001-synergistically-induces-both-autophagy-and-apoptosis-in-prostate-cancer-cells
#18
Sheng Tai, Lingfan Xu, Ming Xu, Ligang Zhang, Yangyang Zhang, Kaipin Zhang, Li Zhang, Chaozhao Liang
The inhibitor of PI3K-AKT-mTOR pathway, such as Rad001, has not shown therapeutic efficacy as a single agent in prostate cancer. Arsenic trioxide induces the autophagic pathway in prostate cancer cells. We identified Arsenic trioxide can synergize with Rad001 to induce cytotoxicity of prostate cancer cells. Moreover, we identified synergistic induction of autophagy and apoptosis as the underlying mechanism. This enhanced autophagic cell death is accompanied by increased Beclin1 mRNA stability as well as upregulation of ATG5-ATG12 conjugate, Beclin1, and LC3-2...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28040261/refinement-of-arsenic-attributable-health-risks-in-rural-pakistan-using-population-specific-dietary-intake-values
#19
Hifza Rasheed, Rebecca Slack, Paul Kay, Yun Yun Gong
BACKGROUND: Previous risk assessment studies have often utilised generic consumption or intake values when evaluating ingestion exposure pathways. If these values do not accurately reflect the country or scenario in question, the resulting risk assessment will not provide a meaningful representation of cancer risks in that particular country/scenario. OBJECTIVES: This study sought to determine water and food intake parameters for one region in South Asia, rural Pakistan, and assess the role population specific intake parameters play in cancer risk assessment...
December 28, 2016: Environment International
https://www.readbyqxmd.com/read/28035418/realgar-transforming-solution-displays-anticancer-potential-against-human-hepatocellular-carcinoma-hepg2-cells-by-inducing-ros
#20
Peng Song, Peng Chen, Dong Wang, Zhengrong Wu, Qiyu Gao, Aixia Wang, Ruilan Zhu, Yajun Wang, Xin Wang, Longhe Zhao, Ziyun Duan, Shuqian Zhu, Peng Cui, Yang Li, Hongyu Li
Realgar (As4S4), as a mineral drug containing arsenic compound, has been employed in clinical therapy of cancer for its good therapeutic reputation in Chinese traditional medicine. However, large dose of realgar and long period of treatment are necessary for achieving the effective blood medicine concentration due to its low bioavailability resulted from poor solubility. In this study, we obtained realgar transforming solution (RTS) using intrinsic biotransformation in microorganism, and investigated underlying mechanisms of RTS for HepG2 cells...
February 2017: International Journal of Oncology
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