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JOURNAL ARTICLE
Vanniaraj Santhana Kumar, Dhruba Jyoti Sarkar, Basanta Kumar Das, Srikanta Samanta, Gayatri Tripathi, Soma Das Sarkar, Anjon Talukder
The present study explores the use of periphyton to ameliorate toxic properties of arsenic (As) to Labeo rohita and also assesses the human food safety aspects. Fish were introduced to arsenite [As(III)] contaminated water (0.3 and 3 mg/L) along with periphyton. Biochemical, physiological and immunological parameters, including gene expression, were assessed after 30 days of exposure. Periphyton incorporation significantly improved (p < 0.05) the adverse effects of As on respiration, NH3 excretion and brain AChE activity by reducing oxidative stress and As bioaccumulation...
May 4, 2024: Environmental Science and Pollution Research International
#2
JOURNAL ARTICLE
Asmat Ali, Zahid Ullah, Nayab Ismaeel, Abdur Rashid, Warda Khalid, Maria Siddique, Javed Iqbal, Anwarzeb Khan, Muhammad Waqas, Junaid Ghani
Groundwater contamination with arsenic (As) is a significant concern in Pakistan's Punjab Province. This study analyzed 69 groundwater samples from Faisalabad, Gujranwala, Lahore, and Multan to understand hydrogeochemistry, health impacts, contamination sources, and drinking suitability. Results revealed varying as concentrations across districts, with distinctive cation and anion orders. Faisalabad exhibited Na+ > Mg2+ > Ca2+ > K+ > Fe2+ for cations and SO4 2- > Cl- > HCO3 - > NO3 - > F- for anions...
May 4, 2024: Environmental Science and Pollution Research International
#3
JOURNAL ARTICLE
Kumudhavalli Dhanasekaran, R Tamizhselvi, Sonaimuthu Mohandoss, Maya Beena, Arunkumar Palaniappan, Ayyakannu Arumugam Napoleon
A Schiff-base Ethyl (E)-2-(3-((2-carbamothioylhydrazono)methyl)-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate (TZTS) dual functional colorimetric and photoluminescent chemosensor which includes thiazole and thiosemicarbazide has been synthesized to detect arsenic (As3+ ) ions selectively in DMSO: H2 O (7:3, v/v) solvent system. The molecular structure of the probe was characterized via FT-IR, 1 H, and 13 C NMR & HRMS analysis. Interestingly, the probe exhibits a remarkable and specific colorimetric and photoluminescence response to As3+ ions when exposed to various metal cations...
April 23, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
#4
JOURNAL ARTICLE
Vijayakumar Balamanikandan, Rajendran Shalini, Ulaganathan Arisekar, Robinson Jeya Shakila, Pandurangan Padmavathy, Balasubramanian Sivaraman, Sandhanasamy Devanesan, Shanmugam Sundhar, Mohamad S AlSalhi, R Mythili, Woong Kim
The presence of toxic trace elements (TEs) has resulted in a worldwide deterioration in freshwater ecosystem quality. This study aimed to analyze the distribution of TEs, including chromium (Cr), nickel (Ni), arsenic (As), mercury (Hg), cadmium (Cd), and lead (Pb), in water, sediment, and organs of Tilapia (Oreochromis mossambicus) collected from selected inland water bodies in Tamil Nadu, India. The water samples exhibited a range of concentrations for TEs: Cr varied from 0.014 to 5.193 µg/L, Ni ranged from 0...
May 2, 2024: Environmental Geochemistry and Health
#5
JOURNAL ARTICLE
Michael S Bank, Quang Tri Ho, Tina Kutti, Tanja Kögel, Ilia Rodushkin, Terje van der Meeren, Martin Wiech, Samuel Rastrick
Sea disposal of mine tailings in fjord ecosystems is an important coastal management issue in Norway and occurs at the land-sea interface. Here we studied accumulation of heavy metals in brown crab (Cancer pagurus) and seafloor sediment from Jøssingfjord, Norway during 2018 to evaluate long-term, legacy pollution effects of coastal mine tailing sea disposal activities. Nickel and copper sediment pollution in the mine tailing sea disposal area was classified as moderate and severe, respectively, under Norwegian environmental quality standards, and highlights the persistent hazard and legacy impacts of heavy metals in these impacted fjord ecosystems...
April 24, 2024: Journal of Hazardous Materials
#6
JOURNAL ARTICLE
Tahmida Naher Chowdhury, Md Mahmudul Hasan, Gulam Md Munna, Md Jahir Bin Alam, Ahmad Hasan Nury, Shriful Islam, Tajmun Naher
This study investigates groundwater contamination by arsenic and iron and its health implications within the Sylhet district in Bangladesh. Utilizing geographic information system (GIS) and inverse distance weighting (IDW) methods, hazard maps have been developed to evaluate contamination risk across various upazilas. The findings show significant arsenic and iron pollution, particularly in the northwestern part of the district. In about 50% of the area, especially in Jaintiapur, Zakiganj, Companiganj, and Kanaighat where arsenic levels surpass 0...
April 2024: Journal of Water and Health
#7
REVIEW
Kacper Zbieralski, Jacek Staszewski, Julia Konczak, Natalia Lazarewicz, Malgorzata Nowicka-Kazmierczak, Donata Wawrzycka, Ewa Maciaszczyk-Dziubinska
In the face of flourishing industrialization and global trade, heavy metal and metalloid contamination of the environment is a growing concern throughout the world. The widespread presence of highly toxic compounds of arsenic, antimony, and cadmium in nature poses a particular threat to human health. Prolonged exposure to these toxins has been associated with severe human diseases, including cancer, diabetes, and neurodegenerative disorders. These toxins are known to induce analogous cellular stresses, such as DNA damage, disturbance of redox homeostasis, and proteotoxicity...
April 18, 2024: International Journal of Molecular Sciences
#8
JOURNAL ARTICLE
Michele C Toledo, Janice S Lee, Bruno Lemos Batista, Kelly P K Olympio, Adelaide C Nardocci
Infant cereals, one of the first solid foods introduced to infants, have been reported to pose risks to human health because they contain toxic elements and an excess of essential elements. The objective of this study was to assess the cancer and non-cancer risk of exposure to essential and toxic elements in infant cereal in Brazil. In our analyses, we included data from 18 samples of infant cereals made from different raw materials and estimated the incremental lifetime cancer risks and non-cancer hazard quotients (HQs) for their consumption...
March 22, 2024: International Journal of Environmental Research and Public Health
#9
JOURNAL ARTICLE
Claire Freycon, Edith Sepulchre, Vincent-Philippe Lavallée, David Mitchell, Margaret L MacMillan, Catherine Vezina, Catherine Goudie
Acute promyelocytic leukemia (APL) represents 5%-10% of childhood acute myeloid leukemia (AML) and is the most curable subtype of AML. Fanconi anemia (FA) is one of the most common inherited bone marrow failure syndromes caused by biallelic pathogenic variants (PV) in specific DNA-repair genes. Biallelic PVs in FANCD1/BRCA2 (FA-D1) account for 3% of FA and are associated with early-onset leukemia and a high risk of solid tumors. We report a 4 year-old boy from non-consanguineous parents diagnosed with standard risk APL...
April 24, 2024: Clinical Genetics
#10
JOURNAL ARTICLE
Hui Li, Yaning Guo, Wei Su, Huan Zhang, Xiaoxi Wei, Xinyu Ma, Shuwen Gong, Gaoyang Qu, Lin Zhang, Hong Xu, Fuhai Shen, Shoufang Jiang, Dingjie Xu, Jinlong Li
Inorganic arsenic is a well-established environmental toxicant linked to acute liver injury, fibrosis, and cancer. While oxidative stress, pyroptosis, and ferroptosis are known contributors, the role of PTEN-induced kinase 1 (PINK1)-mediated mitophagy in arsenic-induced hepatic immunotoxicity remains underexplored. Our study revealed that acute arsenic exposure prompts differentiation of hepatic dendritic cells (DCs) and T helper (Th) 1, Th2, Th17, and regulatory T (Treg) cells, alongside increased transcription factors and cytokines...
April 22, 2024: Ecotoxicology and Environmental Safety
#11
JOURNAL ARTICLE
Mom TatahMentan, Syprose Nyachoti, Tewodros Rango Godebo
Consumption of rice-based foods provides essential nutrients required for infants and toddlers' growth. However, they could contain toxic and excess essential elements that may affect human health. The study aims to determine the composition of rice-based baby foods in the USA and outside and conduct a multiple-life stages probabilistic exposure and risk assessment of toxic and essential elements in children. Elemental concentrations were measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in thirty-three rice-based baby foods...
April 17, 2024: Food and Chemical Toxicology
#12
JOURNAL ARTICLE
Mahmoud Taghavi, Amir Shadboorestan, Laleh R Kalankesh, Afshin Mohammadi-Bardbori, Hamid Reza Ghaffari, Omid Safa, Gholamreza Farshidfar, Mahmoud Omidi
This study aims to explore the potential health risks linked to four heavy metals/metalloids (Pb, Cd, As, Hg) present in four commercially important fish species (Scombromorus commerson, Pseudorhombus elevatus, Thunnus tonggol and Otolithes ruber) in the Persian Gulf. Metals in fish muscle tissue were analyzed via ICP-MS. The analysis revealed that Scombromorus commerson (except for Pb) and Thunnus tonggol (except for As) exhibited the highest and lowest contamination levels, respectively. The Hazard Index findings highlighted arsenic and mercury as the most hazardous elements...
April 17, 2024: Marine Pollution Bulletin
#13
JOURNAL ARTICLE
Xuan Liu, Jay R Turner, Christopher R Oxford, Jacob McNeill, Brenna Walsh, Emmie Le Roy, Crystal L Weagle, Emily Stone, Haihui Zhu, Wenyu Liu, Zilin Wei, Nicole P Hyslop, Jason Giacomo, Ann M Dillner, Abdus Salam, Al-Amin Hossen, Zubayer Islam, Ihab Abboud, Clement Akoshile, Omar Amador-Muñoz, Nguyen Xuan Anh, Araya Asfaw, Rajasekhar Balasubramanian, Rachel Ying-Wen Chang, Craig Coburn, Sagnik Dey, David J Diner, Jinlu Dong, Tareq Farrah, Paterne Gahungu, Rebecca M Garland, Michel Grutter de la Mora, Sina Hasheminassab, Juanette John, Jhoon Kim, Jong Sung Kim, Kristy Langerman, Pei-Chen Lee, Puji Lestari, Yang Liu, Tesfaye Mamo, Mathieu Martins, Olga L Mayol-Bracero, Mogesh Naidoo, Sang Seo Park, Yoav Schechner, Robyn Schofield, Sachchida N Tripathi, Eli Windwer, Ming-Tsang Wu, Qiang Zhang, Michael Brauer, Yinon Rudich, Randall V Martin
Global ground-level measurements of elements in ambient particulate matter (PM) can provide valuable information to understand the distribution of dust and trace elements, assess health impacts, and investigate emission sources. We use X-ray fluorescence spectroscopy to characterize the elemental composition of PM samples collected from 27 globally distributed sites in the Surface PARTiculate mAtter Network (SPARTAN) over 2019-2023. Consistent protocols are applied to collect all samples and analyze them at one central laboratory, which facilitates comparison across different sites...
April 12, 2024: ACS EST Air
#14
JOURNAL ARTICLE
Ayse Nilgun Kul, Bahar Ozturk Kurt
Trace elements are essential micronutrients for the human body. Their roles are indispensable, as they are involved in a wide range of vital biological processes. In this study, we aimed to evaluate alterations in trace elements in the blood and bone marrow serum of patients with newly diagnosed multiple myeloma (NMM). The levels of zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), magnesium (Mg), selenium (Se), arsenic (As), boron (B), nickel (Ni), silicon (Si) and chromium (Cr) were analyzed in the venous blood samples of the patient group comprising 70 patients with NMM (41 males and 29 females) and compared to those in the control group comprising 30 individuals (18 males and 12 females)...
April 17, 2024: Clinical and Experimental Medicine
#15
JOURNAL ARTICLE
Liz Mittal, Camarie S Perry, Alexander D Blanchette, Deborah M Proctor
Electric arc furnace (EAF) slag is a coproduct of steel production used primarily for construction purposes. Some applications of EAF slag result in residential exposures by incidental ingestion and inhalation of airborne dust. To evaluate potential health risks, an EAF slag characterization program was conducted to measure concentrations of metals and leaching potential (including oral bioaccessibility) in 38 EAF slag samples. Arsenic, hexavalent chromium, iron, vanadium, and manganese (Mn) were identified as constituents of interest (COIs)...
April 15, 2024: Risk Analysis: An Official Publication of the Society for Risk Analysis
#16
REVIEW
Mehrad Nikravesh, Saeed Ghanbari, Mahdiehsadat Badiee, Kourosh Zarea, Mehrnoosh Moosavi, Mehrnoush Matin
Arsenic (As) is an environmental pollutant with carcinogenic effects and breast cancer (BC) is a prevalent malignant tumor in women. The goal of this meta-analysis was to establish a connection between biological sample As levels and the risk of developing BC. Pub Med, Web of Science, Scopus, and Elsevier were used to systematically screen the literature published between 1990 and 2023. The Newcastle-Ottawa scale was also used in assessing the quality of publications. A random-effects model was used to assess the pertinent data that was gleaned from these articles...
April 15, 2024: Biological Trace Element Research
#17
JOURNAL ARTICLE
Maiko Sakamoto, Arun Kumar, Deokrishna Kumar Choudhary, Akhouri Bishwapriya, Ashok Ghosh
Recently, a substantial increase in gallbladder cancer (GBC) cases has been reported in Bihar, India. The region's groundwater can naturally contain harmful concentrations of arsenic, which appears to be epidemiologically linked to the unusually high incidence. However, the root causes remain largely unexplored. Recent findings of uranium in the state's groundwater may also have associations. This study investigates the geo-spatial epidemiology of GBC in Bihar, India-with a focus on the correlation between environmental carcinogens, particularly arsenic and uranium in groundwater, and the incidence of GBC...
April 12, 2024: Science of the Total Environment
#18
REVIEW
Pierre Bercier, Hugues de Thé
The story of acute promyelocytic leukemia (APL) discovery, physiopathology, and treatment is a unique journey, transforming the most aggressive form of leukemia to the most curable. It followed an empirical route fueled by clinical breakthroughs driving major advances in biochemistry and cell biology, including the discovery of PML nuclear bodies (PML NBs) and their central role in APL physiopathology. Beyond APL, PML NBs have emerged as key players in a wide variety of biological functions, including tumor-suppression and SUMO-initiated protein degradation, underscoring their broad importance...
March 29, 2024: Cancers
#19
RANDOMIZED CONTROLLED TRIAL
Jie Tian, Yong-Ping Song, Gao-Chong Zhang, Shu-Fang Wang, Xiao-Xiang Chu, Ye Chai, Chun-Ling Wang, Ai-Li He, Feng Zhang, Xu-Liang Shen, Wei-Hua Zhang, Lin-Hua Yang, Da-Nian Nie, Dong-Mei Wang, Huan-Ling Zhu, Da Gao, Shi-Feng Lou, Ze-Ping Zhou, Guo-Hong Su, Yan Li, Jin-Ying Lin, Qing-Zhi Shi, Gui-Fang Ouyang, Hong-Mei Jing, Sai-Juan Chen, Jian Li, Jian-Qing Mi
PURPOSE: The synergistic effects of combining arsenic compounds with imatinib against chronic myeloid leukemia (CML) have been established using in vitro data. We conducted a clinical trial to compare the efficacy of the arsenic realgar-indigo naturalis formula (RIF) plus imatinib with that of imatinib monotherapy in patients with newly diagnosed chronic phase CML (CP-CML). METHODS: In this multicenter, randomized, double-blind, phase 3 trial, 191 outpatients with newly diagnosed CP-CML were randomly assigned to receive oral RIF plus imatinib (n = 96) or placebo plus imatinib (n = 95)...
April 11, 2024: Journal of Cancer Research and Clinical Oncology
#20
JOURNAL ARTICLE
Ahmad Safari Maleki, Mohammad Hossein Ghahremani, Amir Shadboorestan
Although humans are frequently exposed to multiple pollutants simultaneously, research on their harmful effects on health has typically focused on studying each pollutant individually. Inorganic arsenic (As) and benzo[a]pyrene (BaP) are well-known pollutants with carcinogenic potential, but their co-exposure effects on breast cancer cell progression remain incompletely understood. This study aimed to assess the combined impact of BaP and As on the viability and migration of MDA-MB-231 cells. The results indicated that even at low levels, both inorganic As (0...
April 11, 2024: Biological Trace Element Research
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