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https://www.readbyqxmd.com/read/29454203/metals-and-arsenic-in-fish-from-a-ramsar-site-under-past-and-present-human-pressures-consumption-risk-factors-to-the-local-population
#1
Paloma Kachel Gusso-Choueri, Giuliana Seraphim de Araújo, Ana Carolina Feitosa Cruz, Tatiana Roselena de Oliveira Stremel, Sandro Xavier de Campos, Denis Moledo de Souza Abessa, Ciro Alberto de Oliveira Ribeiro, Rodrigo Brasil Choueri
The risk of metals and As in seafood for traditional populations living in a Marine Protected Areas (MPA) is seldom assessed, although the risk of human exposure to contaminants is one of the indicators associated with the socioeconomic goals of MPAs. The current study aimed to estimate the potential risk of some metals (Cd, Pb, and Zn) and arsenic (As) for human health through the ingestion of fish locally harvested in a Ramsar site, the Cananéia-Iguape-Peruíbe Environmental Protected Area (APA-CIP). Previous studies showed environmental impacts in this area due to former mining activities and urbanization...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29444482/exposure-and-risk-assessment-to-arsenic-species-in-spanish-children-using-biomonitoring
#2
Vicent Yusà, Rosa Pérez, Alfredo Sánchez, Olga Pardo, Marta Roca
We present a new approach to arsenic (As) risk assessment using biomonitoring. In this pilot study we determined the levels of total and speciated urinary arsenicin 109 Spanish school children aged between 6 and 11 years, and interpreted these concentrations in a risk assessment context. The geometric mean (GM) for total As (TAs) was 33.82 μ/L. The order of occurrence and average concentrations of the different species was arsenobetaine (AsB) (100%, 15 μg/L), dimethylarsinic (DMA) (97%, 8.32 μg/L), monomethylarsonic (MMA) (26%, 0...
February 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29434902/chloroquine-exerts-antitumor-effects-on-nb4-acute-promyelocytic-leukemia-cells-and-functions-synergistically-with-arsenic-trioxide
#3
Shousheng Liu, Xiuyu Cai, Liangping Xia, Chang Jiang, Ping Chen, Xiaopai Wang, Bei Zhang, Hong Yun Zhao
Chloroquine (CQ) has been confirmed to exhibit antitumor effects on different types of cancer cell, but whether it exerts the same effect on acute promyelocytic leukemia (APL) cells remains to be confirmed. In the present study, the effects of various concentrations of CQ on the growth, apoptosis and cell cycle distribution of NB4 cells, as well as the potential mechanisms underlying these effects, were examined. The combined effect of CQ and arsenic trioxide (ATO) on the growth of NB4 cells was also determined...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29429111/health-risk-assessment-of-drinking-arsenic-containing-groundwater-in-hasilpur-pakistan-effect-of-sampling-area-depth-and-source
#4
Riaz Ahmad Tabassum, Muhammad Shahid, Camille Dumat, Nabeel Khan Niazi, Sana Khalid, Noor Samad Shah, Muhammad Imran, Samina Khalid
Currently, several news channels and research publications have highlighted the dilemma of arsenic (As)-contaminated groundwater in Pakistan. However, there is lack of data regarding groundwater As content of various areas in Pakistan. The present study evaluated As contamination and associated health risks in previously unexplored groundwater of Hasilpur-Pakistan. Total of 61 groundwater samples were collected from different areas (rural and urban), sources (electric pump, hand pump, and tubewell) and depths (35-430 ft or 11-131 m)...
February 10, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29425784/the-reach-of-human-health-risks-associated-with-metals-metalloids-in-water-and-vegetables-along-a-contaminated-river-catchment-south-africa-and-mozambique
#5
Bettina Genthe, Thandi Kapwata, Wouter Le Roux, Jessica Chamier, Caradee Y Wright
BACKGROUND: Anthropogenic pollution was identified as an environmental problem of concern when, in 2008, dozens of crocodiles died in the Olifants River catchment near the border of South Africa and Mozambique. Given the close proximity of households to the river and their making use of river water, we aimed to determine to what extent water pollution has an impact on health of indigent communities in South Africa and Mozambique in the catchment area. METHODS: Water and vegetable samples were collected from the study areas...
February 1, 2018: Chemosphere
https://www.readbyqxmd.com/read/29420223/oxidative-phosphorylation-as-an-emerging-target-in-cancer-therapy
#6
Thomas M Ashton, W Gillies McKenna, Leoni A Kunz-Schughart, Geoff S Higgins
Cancer cells have upregulated glycolysis compared to normal cells, which has led many to the assumption that oxidative phosphorylation (OXPHOS) is downregulated in all cancers.  However, recent studies have shown that OXPHOS can be also upregulated in certain cancers, including leukemias, lymphomas, pancreatic ductal adenocarcinoma, high OXPHOS subtype melanoma and endometrial carcinoma, and that this can occur even in the face of active glycolysis.  OXPHOS inhibitors could therefore be used to target cancer subtypes in which OXPHOS is upregulated, and to alleviate therapeutically adverse tumor hypoxia...
February 2, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29417982/how-or-when-samples-are-collected-affects-measured-arsenic-concentration-in-new-drinking-water-wells
#7
Melinda L Erickson, Helen F Malenda, Emily C Berquist
Naturally occurring arsenic can adversely affect water quality in geologically diverse aquifers throughout the world. Chronic exposure to arsenic via drinking water is a human health concern due to risks for certain cancers, skin abnormalities, peripheral neuropathy, and other negative health effects. Statewide in Minnesota, USA, 11% of samples from new drinking water wells have arsenic concentrations exceeding 10 μg/L; in certain counties more than 35% of tested samples exceed 10 μg/L arsenic. Since 2008 Minnesota well code has required testing water from new wells for arsenic...
February 8, 2018: Ground Water
https://www.readbyqxmd.com/read/29411302/long-term-health-effects-and-underlying-biological-mechanisms-of-developmental-exposure-to-arsenic
#8
REVIEW
Lisa Smeester, Rebecca C Fry
PURPOSE OF REVIEW: Exposure to inorganic arsenic (iAs) via drinking water represents a significant global public health threat with chronic exposure associated with cancer, skin lesions, neurological impairment, and cardiovascular diseases. Particularly susceptible populations include the developing fetus and young children. This review summarizes some of the critical studies of the long-term health effects and underlying biological mechanisms related to developmental exposure to arsenic...
February 6, 2018: Current Environmental Health Reports
https://www.readbyqxmd.com/read/29410996/modulation-of-thiol-dependent-redox-system-by-metal-ions-via-thioredoxin-and-glutaredoxin-systems
#9
REVIEW
Yanfang Ouyang, Yi Peng, Jing Li, Arne Holmgren, Jun Lu
The thioredoxin and glutaredoxin systems possess a variety of biological activities in mammalian cells, including the defense against oxidative stress, regulation of DNA synthesis, the cell cycle and the mediation of apoptosis. The thioredoxin system, comprised of NADPH, thioredoxin reductase (TrxR) and thioredoxin (Trx), exerts its activities via a disulfide-dithiol exchange reaction. Mammalian TrxRs are selenoproteins; the thiols and selenols in the active site of these enzymes confer the thioredoxin system to work as soft bases, which have a high affinity with soft acids, including numerous metal ions...
February 7, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29409467/arsenic-trioxide-attenuates-stat-3-activity-and-epithelial-mesenchymal-transition-through-induction-of-shp-1-in-gastric-cancer-cells
#10
Sung Ho Kim, Hyo Soon Yoo, Moon Kyung Joo, Taehyun Kim, Jong-Jae Park, Beom Jae Lee, Hoon Jai Chun, Sang Woo Lee, Young-Tae Bak
BACKGROUND: We investigated the effect of arsenic trioxide (ATO) for inhibition of signal transducer and activator of transcription 3 (STAT3) and epithelial-mesenchymal transition (EMT) in gastric cancer cells, and the role of SH2 domain-containing phosphatase-1 (SHP-1) during this process. METHODS: We used AGS cells, which showed minimal SHP-1 expression and constitutive STAT3 expression. After treatment of ATO, cellular migration and invasion were assessed by using wound closure assay, Matrigel invasion assay and 3-D culture invasion assay...
February 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29408041/low-level-arsenic-causes-proteotoxic-stress-and-not-oxidative-stress
#11
Matthew Dodson, Montserrat Rojo de la Vega, Bryan Harder, Raul Castro-Portuguez, Silvia D Rodrigues, Pak Kin Wong, Eli Chapman, Donna D Zhang
Prolonged exposure to arsenic has been shown to increase the risk of developing a number of diseases, including cancer and type II diabetes. Arsenic is present throughout the environment in its inorganic forms, and the level of exposure varies greatly by geographical location. The current recommended maximum level of arsenic exposure by the EPA is 10μg/L, but levels>50-1000μg/L have been detected in some parts of Asia, the Middle East, and the Southwestern United States. One of the most important steps in developing treatment options for arsenic-linked pathologies is to understand the cellular pathways affected by low levels of arsenic...
February 15, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29407784/effect-of-selenium-induced-seed-priming-on-arsenic-accumulation-in-rice-plant-and-subsequent-transmission-in-human-food-chain
#12
Debojyoti Moulick, Subhas Chandra Santra, Dibakar Ghosh
The south-east Asian countries are facing a serious threat of arsenic (As) toxicity due to extensive use of As contaminated groundwater for rice cultivation. This experiment was configured to assess the consequences of rice seed priming with selenium (Se) and cultivation in As free and As contaminated soil. The experiment was arranged in a factorial complete randomized design having two factors viz. seed priming and soil As stress with total twenty-five treatment combinations replicated thrice. Seed priming with Se promotes growth, yield under both As free and As stressed conditions...
January 25, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29407475/systematic-review-and-health-risk-assessment-of-arsenic-and-lead-in-the-fished-shrimps-from-the-persian-gulf
#13
Yadolah Fakhri, Anoushiravan Mohseni-Bandpei, Gea Oliveri Conti, Margherita Ferrante, Antonio Cristaldi, Ali Khani Jeihooni, Maryam Karimi Dehkordi, Abdolazim Alinejad, Hassan Rasoulzadeh, Seyed Mohsen Mohseni, Maryam Sarkhosh, Hassan Keramati, Bigard Moradi, Nazak Amanidaz, Zahra Baninameh
The ingestion of heavy metals through contaminated seafood can causes significant outcomes on human health. In recent years, consume fishes and shrimps has increased in Iran, and several study about heavy metals content in fishes and shrimps from Persian Gulf were carried out to check their food safety. The aims of these systematic reviews and meta-analysis was to summarize the evidence on the relation of the intakes of Arsenic (As) and lead (Pb) levels, based on the origin and sub-groups of shrimp species consumed, Hence that we can estimate the risk of oral cancer induced by Pb and As in these groups of shrimp from the persian gulf...
January 31, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29399180/characteristics-of-doxorubicin-selected-multidrug-resistant-human-leukemia-hl-60-cells-with-tolerance-to-arsenic-trioxide-and-contribution-of-leukemia-stem-cells
#14
Jing Chen, Hulai Wei, Jie Cheng, Bei Xie, Bei Wang, Juan Yi, Baoying Tian, Zhuan Liu, Feifei Wang, Zhewen Zhang
The present study selected and characterized a multidrug-resistant HL-60 human acute promyelocytic leukemia cell line, HL-60/RS, by exposure to stepwise incremental doses of doxorubicin. The drug-resistant HL-60/RS cells exhibited 85.68-fold resistance to doxorubicin and were cross-resistant to other chemotherapeutics, including cisplatin, daunorubicin, cytarabine, vincristine and etoposide. The cells over-expressed the transporters P-glycoprotein, multidrug-resistance-related protein 1 and breast-cancer-resistance protein, encoded by the adenosine triphosphate-binding cassette (ABC)B1, ABCC1 and ABCG2 genes, respectively...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29396848/arsenic-promotes-the-cox2-pge2-sox2-axis-to-increase-the-malignant-stemness-properties-of-urothelial-cells
#15
Akira Ooki, Asma Begum, Luigi Marchionni, Christopher J VandenBussche, Shifeng Mao, Kates Max, Mohammad Obaidul Hoque
Chronic arsenic exposure is associated with the development of urothelial carcinoma of the bladder (UCB). To elucidate the contribution of arsenic exposure to urothelial cancer stem cell (CSC) generation, we established an in vitro stepwise malignant model transformed by chronically exposing human urothelial cells to arsenic. Using this model, we found that chronic arsenic exposure endows urothelial cells with malignant stemness properties including increased expression of stemness-related factors such as SOX2, sphere formation, self-renewal, invasion, and chemo-resistance...
February 2, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29396610/arsenic-trioxide-insights-into-its-evolution-to-an-anticancer-agent
#16
REVIEW
Maneka Hoonjan, Vaibhav Jadhav, Purvi Bhatt
Arsenic and its various forms have been in use in ancient Chinese medicine for more than 2000 years. Arsenicals have gained importance for having remedial effects for various diseases from syphilis to cancer thus highlighting its role as a therapeutic agent even though it has been labelled as a potential 'poison'. The ability of arsenic, specifically arsenic trioxide, to treat acute promyelocytic leukaemia has radically changed the perception of this poison and has been the main factor for the re-emergence of this candidate to Western medicine for the treatment of leukaemia and other solid tumours...
February 2, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29392546/potential-health-risk-assessment-through-ingestion-and-dermal-contact-arsenic-contaminated-groundwater-in-jianghan-plain-china
#17
Ran Li, Yi-Ming Kuo, Wen-Wen Liu, Cheng-Shin Jang, Enmin Zhao, Liquan Yao
Groundwater contamination with high arsenic (As) levels has caused serious health problem in Jianghan Plain. This study presents a framework to evaluate the results and their probable influencing factors of non-carcinogenic risk and carcinogenic risk in Shahu Village. An appropriate health risk assessment for residents exposing to As through ingestion and dermal contact pathways is also discussed in the paper. Hazard quotient (HQ) and target cancer risk (TR) are adopted to compute the non-carcinogenic and carcinogenic effects for residents, respectively...
February 1, 2018: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/29391828/toxic-elements-as-biomarkers-for-breast-cancer-a-meta-analysis-study
#18
REVIEW
Leila Jouybari, Marzieh Saei Ghare Naz, Akram Sanagoo, Faezeh Kiani, Fatemeh Sayehmiri, Kourosh Sayehmiri, Ali Hasanpour Dehkordi
Aims and background: Breast cancer (BC) is responsible for a large proportion of incidence of cancer in the world. Identifying the risk factors contributing to the incidence of BC is crucial to find efficient preventive and management strategies for this disease. Several studies have examined Arsenic (As), Cadmium (Cd), and Nickel (Ni) as risk factors for BC. The present study aimed at studying the link between As, Cd, and Ni concentrations and BC by using a meta-analysis. Materials and methods: All case-control studies addressing the relationship between As, Cd, and Ni concentrations with BC were identified through electronic search databases (Scopus, ISI Web of Science, PubMed, EmBase, and Cochrane Library)...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29389803/antileukemic-effects-of-neurokinin-1-receptor-inhibition-on-hematologic-malignant-cells-a-novel-therapeutic-potential-for-aprepitant
#19
Samaneh Bayati, Elham Razani, Davood Bashash, Ava Safaroghli-Azar, Majid Safa, Seyed H Ghaffari
Genetic and laboratory studies have remodeled the conventional understanding of cancer pathogenesis by identifying different molecular alterations. Intrigued by the contribution of neurokinin-1 receptor (NK1R) network in cancer pathogenesis, we investigated the antileukemic effects of aprepitant, a nonpeptide antagonist of NK1R, in a panel of hematological cell lines. In this study, we found that aprepitant decreased the survival of all the tested cells; however, as compared with NB4, viability of the other cell lines was inhibited at higher concentrations...
January 31, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29381475/the-role-of-nutrition-in-influencing-mechanisms-involved-in-environmentally-mediated-diseases
#20
REVIEW
Bernhard Hennig, Michael C Petriello, Mary V Gamble, Young-Joon Surh, Laura A Kresty, Norbert Frank, Nuchanart Rangkadilok, Mathuros Ruchirawat, William A Suk
Human exposure to environmental contaminants such as persistent chlorinated organics, heavy metals, pesticides, phthalates, flame retardants, electronic waste and airborne pollutants around the world, and especially in Southeast Asian regions, are significant and require urgent attention. Given this widespread contamination and abundance of such toxins as persistent organic pollutants (POPs) in the ecosystem, it is unlikely that remediation alone will be sufficient to address the health impacts associated with this exposure...
January 30, 2018: Reviews on Environmental Health
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