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https://www.readbyqxmd.com/read/27918984/hypertension-among-adults-exposed-to-drinking-water-arsenic-in-northern-chile
#1
Emily M Hall, Johanna Acevedo, Francisca González López, Sandra Cortés, Catterina Ferreccio, Allan H Smith, Craig M Steinmaus
BACKGROUND: A growing number of studies have identified an association between exposure to inorganic arsenic and hypertension. However, results have not been consistent across studies. Additional studies are warranted, given the global prevalence of both arsenic exposure and morbidity attributable to hypertension. METHODS: We analyzed data collected from October 2007-December 2010 for a population-based cancer case-control study in northern Chile. Data included lifetime individual arsenic exposure estimates and information on potential confounders for a total of 1266 subjects...
December 2, 2016: Environmental Research
https://www.readbyqxmd.com/read/27908234/sustained-early-disruption-of-mitochondrial-function-contributes-to-arsenic-induced-prostate-tumorigenesis
#2
B Singh, M Kulawiec, K M Owens, A Singh, K K Singh
Arsenic is a well-known human carcinogen that affects millions of people worldwide, but the underlying mechanisms of carcinogenesis are unclear. Several epidemiological studies have suggested increased prostate cancer incidence and mortality due to exposure to arsenic. Due to lack of an animal model of arsenic-induced carcinogenesis, we used a prostate epithelial cell culture model to identify a role for mitochondria in arsenic-induced prostate cancer. Mitochondrial morphology and membrane potential was impacted within a few hours of arsenic exposure of non-neoplastic prostate epithelial cells...
October 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/27901016/relationships-between-arsenic-concentrations-in-drinking-water-and-lung-and-bladder-cancer-incidence-in-u-s-counties
#3
William M Mendez, Sorina Eftim, Jonathan Cohen, Isaac Warren, John Cowden, Janice S Lee, Reeder Sams
Increased risks of lung and bladder cancer have been observed in populations exposed to high levels of inorganic arsenic. However, studies at lower exposures (i.e., less than 100 μg/l in water) have shown inconsistent results. We therefore conducted an ecological analysis of the association between historical drinking water arsenic concentrations and lung and bladder cancer incidence in U.S. counties. We used drinking water arsenic concentrations measured by the U.S. Geological Survey and state agencies in the 1980s and 1990s as proxies for historical exposures in counties where public groundwater systems and private wells are important sources of drinking water...
November 30, 2016: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/27894683/biomonitoring-of-humans-exposed-to-arsenic-chromium-nickel-vanadium-and-complex-mixtures-of-metals-by-using-the-micronucleus-test-in-lymphocytes
#4
REVIEW
Balasubramanyam Annangi, Stefano Bonassi, Ricard Marcos, Alba Hernández
Various metals have demonstrated genotoxic and carcinogenic potential via different mechanisms. Until now, biomonitoring and epidemiological studies have been carried out to assess the genotoxic risk to exposed human populations. In this sense, the use of the micronucleus assay in peripheral blood lymphocytes has proven to be a useful tool to determine increased levels of DNA damage, as a surrogate biomarker of cancer risk. Here we review those biomonitoring studies focused on people exposed to arsenic, chromium, nickel, vanadium and complex mixtures of metals...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27889806/a-comparative-assessment-of-arsenic-risks-and-the-nutritional-benefits-of-fish-consumption-in-kuwait-arsenic-versus-omega-3-fatty-acids
#5
Adnan Husain, Kurunthachalam Kannan, Hing Man Chan, Brian Laird, Hanan Al-Amiri, Basma Dashti, Anwar Sultan, Amani Al-Othman, Bedraya Mandekar
Inorganic and organic forms of arsenic (As), as well as omega-3 fatty acids were measured in 578 fish/seafood samples that belong to 15 species of commonly consumed seafood in Kuwait. Arsenic speciation data, with the toxicological profile of inorganic arsenic (iAs) and fish consumption rates were applied in a probabilistic risk assessment to estimate the risk from exposure to iAs. The nutritional benefits of omega-3-fatty acid levels in various species of fish were taken into consideration. Results showed that the mean daily intake of iAs through fish consumption among the Kuwaiti population was 0...
November 26, 2016: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27888373/combined-toxic-effect-of-airborne-heavy-metals-on-human-lung-cell-line-a549
#6
Yeowool Choi, Kihong Park, Injeong Kim, Sang D Kim
Many studies have demonstrated that heavy metals existing as a mixture in the atmospheric environment cause adverse effects on human health and are important key factors of cytotoxicity; however, little investigation has been conducted on a toxicological study of a metal mixture from atmospheric fine particulate matter. The objective of this study was to predict the combined effects of heavy metals in aerosol by using in vitro human cells and obtain a suitable mixture toxicity model. Arsenic, nickel, and lead were selected for mixtures exposed to A549 human lung cancer cells...
November 25, 2016: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/27863446/glutathione-transferase-p1-1-as-an-arsenic-drug-sequestering-enzyme
#7
Lorien J Parker, Alessio Bocedi, David B Ascher, Jade B Aitken, Hugh H Harris, Mario Lo Bello, Giorgio Ricci, Craig J Morton, Michael W Parker
Arsenic-based compounds are paradoxically both poisons and drugs. Glutathione transferase (GSTP1-1) is a major factor in resistance to such drugs. Here we describe using crystallography, X-ray absorption spectroscopy, mutagenesis, mass spectrometry and kinetic studies how GSTP1-1 recognizes the drug phenylarsine oxide (PAO). In conditions of cellular stress where glutathione (GSH) levels are low, PAO crosslinks C47 to C101 of the opposing monomer, a distance of 19.9 Å, and causes a dramatic widening of the dimer interface by ∼10 Å...
November 18, 2016: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/27845887/a-review-of-heavy-metals-in-indoor-dust-and-its-human-health-risk-implications
#8
Sock Yin Tan, Sarva Mangala Praveena, Emilia Zainal Abidin, Manraj Singh Cheema
Indoor dust acts as a media for heavy metal deposition. Past studies have shown that heavy metal concentration in indoor dust is affected by local human activities and atmospheric transport can have harmful effects on human health. Additionally, children are more sensitive to heavy metals due to their hand-to-mouth behaviour and rapid body development. However, limited information on health risks were found in past dust studies as these studies aimed to identify heavy metal concentrations and sources of indoor dust...
December 1, 2016: Reviews on Environmental Health
https://www.readbyqxmd.com/read/27815726/agricultural-exposure-and-risk-of-bladder-cancer-in-the-agriculture-and-cancer-cohort
#9
Mathilde Boulanger, Séverine Tual, Clémentine Lemarchand, Anne-Valérie Guizard, Michel Velten, Elisabeth Marcotullio, Isabelle Baldi, Bénédicte Clin, Pierre Lebailly
PURPOSE: Literature on agricultural activities and bladder cancer risk is scarce. However, farmers can be subjected to carcinogenic exposure (e.g. arsenic, previously used as a pesticide in France). This study aimed at assessing the role of a large range of agricultural activities and tasks on bladder cancer risk. METHODS: The study population was the AGRIculture and CANcer cohort, a large prospective cohort of individuals affiliated to the agricultural health insurance scheme (MSA) in France...
November 4, 2016: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/27813108/antagonistic-effect-of-n-ethylmaleimide-on-arsenic-mediated-oxidative-stress-induced-poly-adp-ribosyl-ation-and-cytotoxicity
#10
Alexander Sheng-Shin Wang, Yu-Ting Chou, Yeong-Shiau Pu
Long-term exposure to arsenic has been known to induce neoplastic initiation and progression in several organs; however, the role of arsenic (As2 O3 ) in oxidative stress-mediated DNA damage remains elusive. One of the immediate cellular responses to DNA damage is poly(ADP-ribosyl)ation (PARylation), which mediates DNA repair and enhances cell survival. In this study, we found that oxidative stress (H2 O2 )-induced PARylation was suppressed by As2 O3 exposure in different human cancer cells. Moreover, As2 O3 treatment promoted H2 O2 -induced DNA damage and apoptosis, leading to increased cell death...
November 4, 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/27809548/terpolymer-micelles-for-the-delivery-of-arsenic-to-breast-cancer-cells-the-effect-of-chain-sequence-on-polymeric-micellar-characteristics-and-cancer-cell-uptake
#11
Qi Zhang, Mohammad Reza Vakili, Xing-Fang Li, Afsaneh Lavasanifar, X Chris Le
In this study, we developed a micellar platform composed of terpolymers for the encapsulation of inorganic arsenite or arsenous acid (As(III)). For this purpose, a series of terpolymers composed of poly(ethylene oxide) (PEO, block A), poly(α-carboxylate-ε-carprolactone) (PCCL, block B), and poly(ε-caprolactone) (PCL, block C) with either a blocked, i.e., BC or CB, or random, i.e., (B/C)ran block copolymer sequence in the polyester segment was synthesized. The COOH groups on block B were further modified with mercaptohexylamine for As(III) encapsulation...
November 4, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27803929/advances-in-understanding-how-heavy-metal-pollution-triggers-gastric-cancer
#12
REVIEW
Wenzhen Yuan, Ning Yang, Xiangkai Li
With the development of industrialization and urbanization, heavy metals contamination has become a major environmental problem. Numerous investigations have revealed an association between heavy metal exposure and the incidence and mortality of gastric cancer. The mechanisms of heavy metals (lead, cadmium, mercury, chromium, and arsenic) contamination leading to gastric cancer are concluded in this review. There are four main potential mechanisms: (1) Heavy metals disrupt the gastric mucosal barrier by decreasing mucosal thickness, mucus content, and basal acid output, thereby affecting the function of E-cadherin and inducing reactive oxygen species (ROS) damage...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27797216/inhibition-of-oxidative-stress-and-enhancement-of-cellular-activity-by-mushroom-lectins-in-arsenic-induced-carcinogenesis
#13
REVIEW
Tanmoy Rana, Asit Kumar Bera, Subhashree Das, Debasis Bhattacharya, Diganta Pan, Subrata Kumar Das
Chronic arsenicosis is a major environmental health hazard throughout the world, including India. Animals and human beings are affected due to drinking of arsenic contaminated ground water, due to natural mineral deposits, arsenical pesticides or improperly disposed arsenical chemicals. Arsenic causes cancer with production of free radicals and reactive oxygen species (ROS) that are neutralized by an elaborate antioxidant defense system consisting of enzymes and numerous non-enzymatic antioxidants. Dietary antioxidant supplements are useful to counteract the carcinogenesis effects of arsenic...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27794399/combination-effects-of-arsenic-trioxide-and-fibroblast-growth-factor-receptor-inhibitor-in-squamous-cell-lung-carcinoma
#14
Sze-Kwan Lam, Leanne Lee Leung, Yuan-Yuan Li, Chun-Yan Zheng, James Chung-Man Ho
OBJECTIVES: Lung cancer remains the top cancer killer worldwide, with squamous cell carcinoma (SCC) as the second commonest histologic subtype. Arsenic trioxide (ATO) was previously shown to suppress growth of lung cancer. Fibroblast growth factor receptor (FGFR) amplification was recently demonstrated in lung SCC, with specific FGFR inhibitor (e.g. PD173074) developed as a potential targeted therapy. Therefore the combination effects of ATO and PD173074 in SCC was studied. MATERIALS AND METHODS: The combination of ATO/PD173074 was studied in a proof-of-principle model using a lung SCC cell line with FGFR1 overexpression: SK-MES-1...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27770503/survivin-isoform-expression-in-arsenic-trioxide-treated-acute-promyelocytic-leukemia-cell-line-and-patients-the-odd-expression-pattern-of-survivin-2%C3%AE
#15
Majid Zaki Dizaji, Seyed H Ghaffari, Elham Hosseini, Nasrin Alizadeh, Shahrbano Rostami, Majid Momeny, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
AIM: Survivin, an inhibitor of apoptosis protein, is overexpressed in most cancers and is associated with chemotherapy resistance, increased tumor recurrence and shorter patient survival. Several survivin splice variants have been described, and none of their expressions have been defined in acute promyelocytic leukemia (APL). METHODS: Expression of the survivin gene isoforms (survivin, -2α, -2B, -ΔΕx3 and -3B) were analyzed in 50 peripheral blood and 19 bone marrow samples that were collected at different phases of the disease (diagnostic, remission and relapse) in APL patients treated with arsenic trioxide (ATO) as a front-line therapy...
October 22, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27769816/arsenic-trioxide-induces-cell-cycle-arrest-and-alters-dna-methylation-patterns-of-cell-cycle-regulatory-genes-in-colorectal-cancer-cells
#16
Haniyeh Eyvani, Farima Moghaddaskho, Majid Kabuli, Ali Zekri, Majid Momeny, Javad Tavakkoly-Bazzaz, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Seyed H Ghaffari
AIMS: Cell cycle dysregulation is important in tumorigenesis. Transcriptional silencing of cell cycle regulatory genes, due to DNA methylation, is a common epigenetic event in malignancies. As2O3 has been shown to induce cell cycle arrest and also to be a potential hypomethylating agent. Our study aimed to investigate DNA methylation patterns of cell cycle regulatory genes promoters, the effects of Arsenic trioxide (As2O3) on the methylated genes and cell cycle distribution in colorectal cancer (CRC) cell lines...
October 18, 2016: Life Sciences
https://www.readbyqxmd.com/read/27765800/sex-specific-associations-between-one-carbon-metabolism-indices-and-posttranslational-histone-modifications-in-arsenic-exposed-bangladeshi-adults
#17
Caitlin G Howe, Xinhua Liu, Megan N Hall, Vesna Ilievski, Marie A Caudill, Olga Malysheva, Angela M Lomax-Luu, Faruque Parvez, Abu B Siddique, Hasan Shahriar, Mohammad N Uddin, Tariqul Islam, Joseph H Graziano, Max Costa, Mary V Gamble
BACKGROUND: Posttranslational histone modifications (PTHMs) are altered by arsenic, an environmental carcinogen. PTHMs are also influenced by nutritional methyl donors involved in one-carbon metabolism (OCM), which may protect against epigenetic dysregulation. METHODS: We measured global levels of three PTHMs, which are dysregulated in cancers (H3K36me2, H3K36me3, H3K79me2), in peripheral blood mononuclear cells (PBMCs) from 324 participants enrolled in the Folic Acid and Creatine Trial, a randomized trial in arsenic-exposed Bangladeshi adults...
October 20, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27757244/magnesium-zinc-arsenic-selenium-and-platinum-urinary-excretion-from-cancer-patients-of-antofagasta-region-chile-multi-metal-approach
#18
D A Román, I Pizarro, L Rivera, J Ávila, P Cortés
OBJECTIVES: To evaluate the short-term 24 h urinary excretion of platinum, arsenic, selenium, magnesium and zinc in patients with lung cancer and with cancer other than lungs treated with cisplatin or/and carboplatin from Antofagasta, Chile. DESIGN: Urine measurements of Pt and Se were made by inductively coupled plasma optical emission spectrometry, As by hydride-generation atomic absorption spectrometry and Mg and Zn by means of flame furnace atomic absorption spectrometry...
October 2016: JRSM Open
https://www.readbyqxmd.com/read/27748945/survivint34a-increases-the-therapeutic-efficacy-of-arsenic-trioxide-in-mouse-hepatocellular-carcinoma-models
#19
Anliang Huang, Dan Yue, Danying Liao, Liuliu Cheng, Jinhu Ma, Yuquan Wei, Aiping Tong, Ping Cheng
Arsenic trioxide (ATO) has demonstrated clinical efficacy in acute promyelocytic leukemia (APL) and in vitro activity in various solid tumors. As2O3 as single agent exhibits poor efficacy for treatment of hepatocellular carcinoma (HCC) in phase II trial, suggesting that new modalities of treatment with enhanced therapeutic effect and alleviated toxicity are needed for application of As2O3 on patients with HCC. Survivin is the strongest inhibitor of apoptosis protein over-expressed in tumors, which has been proposed as an attractive target for new anticancer interventions...
October 11, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27735789/nitarsone-inorganic-arsenic-and-other-arsenic-species-in-turkey-meat-exposure-and-risk-assessment-based-on-a-2014-u-s-market-basket-sample
#20
Keeve E Nachman, David C Love, Patrick A Baron, Anne E Nigra, Manuela Murko, Georg Raber, Kevin A Francesconi, Ana Navas-Acien
BACKGROUND: Use of nitarsone, an arsenic-based poultry drug, may result in dietary exposures to inorganic arsenic (iAs) and other arsenic species. Nitarsone was withdrawn from the US market in 2015, but use in other countries may continue. OBJECTIVES: Characterize the impact of nitarsone use on arsenic species in turkey meat and arsenic exposures among turkey consumers, and estimate cancer risk increases from consuming turkey treated with nitarsone prior to its 2015 US withdrawal...
October 13, 2016: Environmental Health Perspectives
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