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arsenic + cancer

Liang-Ting Lin, Shin-Yi Liu, Jyh-Der Leu, Chun-Yuan Chang, Shih-Hwa Chiou, Te-Chang Lee, Yi-Jang Lee
Arsenic trioxide (ATO) is a traditional Chinese medicine that can induce oxidative stress for treatment of cancer cells. However, ATO may generate anti-oxidative responses to compromise the cytotoxic effect, but the underlying mechanisms remain unclear. Here we found that ATO could inhibit miR-182-5p expression in patient-derived primary S1 glioblastoma (GBM) cells accompanied by up-regulation of Sestrin-2 ( SESN2 ) mRNA, a known anti-oxidant molecule. This phenomenon was also detected in a U87MG glioma cell line, human lung adenocarcinoma H1299 cell line and A549 cell line...
March 23, 2018: Oncotarget
Juan Zhang, Yue Zhang, Weiyan Wang, Chunling Li, Zhiyi Zhang
In 1992, arsenic trioxide (As2 O3 , ATO) was demonstrated to be an effective therapeutic agent against acute promyelocytic leukemia (APL), rekindling attention to ATO applications in U.S. Food and Drug Administration clinical trials for the treatment of cancers, such as leukemia, lymphomas, and solid tumors. ATO is a potent chemotherapeutic drug that can also be used to treat other diseases, such as autoimmune diseases, because it affects multiple pathways including apoptosis induction, differentiation stimulation, and proliferation inhibition...
April 9, 2018: Inflammation
Yuxue Zhao, Kenji Onda, Bo Yuan, Sachiko Tanaka, Anna Kiyomi, Kentaro Sugiyama, Munetoshi Sugiura, Norio Takagi, Toshihiko Hirano
In China, arsenic disulfide (As2S2) has been used for the treatment of hematological malignancies. The present study aimed to evaluate the effects of As2S2 on the human breast cancer MCF‑7 cell line cultured in both two‑dimensional (2D) monolayers and three‑dimensional (3D) spheroids to explore its therapeutic potential in breast cancer treatment. Cellular viability and the induction of apoptosis were examined with a cell counting kit‑8 (CCK‑8) assay and flow cytometric analysis, respectively. Alterations in the expression levels of apoptosis‑associated proteins, including Bcl‑2‑associated X protein (Bax), B‑cell lymphoma 2 (Bcl‑2), p53, and caspase‑7, as well as the cell survival‑associated proteins, phosphatidylinositol 3‑kinase (PI3K), Akt, and mammalian target of rapamycin (mTOR), were assessed by western blotting...
April 4, 2018: International Journal of Oncology
Anam Akhtar, Scarlet Xiaoyan Wang, Lucy Ghali, Celia Bell, Xuesong Wen
Despite the success of arsenic trioxide (ATO) in treating haematological malignancies, its potential to treat solid tumours has not been fully exploited, owing to its dose-limiting toxicity and poor pharmacokinetics. In order to overcome this hurdle, liposomal encapsulation of the drug with different surface charges (neutral, negative, and positive) and sizes (100, 200 and 400 nm) were synthesised and tested on human papilloma virus (HPV)-positive HeLa and HPV-negative HT-3 cervical cancer cell lines. Two epithelial cell lines-human keratinocytes (HK) and human colon cells (CRL-1790)-were used as controls...
April 4, 2018: International Journal of Molecular Sciences
Qiao Yi Chen, Jinquan Li, Hong Sun, Feng Wu, Yusha Zhu, Thomas Kluz, Ashley Jordan, Thomas DesMarais, Xiaoru Zhang, Anthony Murphy, Max Costa
Arsenic is a naturally occurring and highly potent metalloid known to elicit serious public health concerns. Today, approximately 200 million people around the globe are exposed to arsenic-contaminated drinking water at levels greater than the World Health Organization's recommended limit of 10 parts per billion. As a class I human carcinogen, arsenic exposure is known to elicit various cancers, including lung, skin, liver, and kidney. Current evidence suggests that arsenic is capable of inducing both genotoxic and cytotoxic injury, as well as activating epigenetic pathways to induce carcinogenesis...
March 30, 2018: Molecular Carcinogenesis
Penradee Chanpiwat, Supanad Hensawang, Parin Suwatvitayakorn, Montree Ponsin
Consumption of contaminated rice is a toxin exposure route in Asian populations. Since total concentrations generally overestimate health risks, the objectives of this study were to determine the levels of bioaccessible As and Cd in rice cultivated in the Mae Tao, Tak Province and evaluate their potential health impacts in local adults. In total, 59 locally grown rice samples were analyzed for their total and bioaccessible concentrations. Bioaccessible concentrations were obtained from an in vitro digestion process...
March 30, 2018: Environmental Geochemistry and Health
Nami Uematsu, Yuxue Zhao, Anna Kiyomi, B O Yuan, Kenji Onda, Sachiko Tanaka, Kentaro Sugiyama, Munetoshi Sugiura, Norio Takagi, Akemi Hayakawa, Toshihiko Hirano
BACKGROUND/AIM: Chemo-sensitivity of two-dimensional (2D) monolayers and three-dimensional (3D) spheroids of human breast cancer MCF-7 cells were investigated. MATERIALS AND METHODS: MCF-7 cells were cultured in monolayers or spheroids established using a thermo-reversible gelatin polymer, in the presence of daunorubicin, docetaxel, or As2 S2 Cell proliferation was examined by a Cell Counting Kit-8 assay. RESULTS: Daunorubicin, docetaxel, and As2 S2 dose-dependently decreased the MCF-7 cell proliferation in both 2D- and 3D-culture systems...
April 2018: Anticancer Research
Anna Lång, Alexander Øye, Jens Eriksson, Alexander D Rowe, Emma Lång, Stig Ove Bøe
During cell division, a large number of nuclear proteins are released into the cytoplasm due to nuclear envelope breakdown. Timely nuclear import of these proteins following exit from mitosis is critical for establishment of the G1 nuclear environment. Dysregulation of post-mitotic nuclear import may affect the fate of newly divided stem or progenitor cells and may lead to cancer. Acute promyelocytic leukemia (APL) is a malignant disorder that involves a defect in blood cell differentiation at the promyelocytic stage...
March 26, 2018: Biochemical and Biophysical Research Communications
Duck Soo Lim, Tae Hyun Roh, Min Kook Kim, Yong Chan Kwon, Seul Min Choi, Seung Jun Kwack, Kyu Bong Kim, Sungpil Yoon, Hyung Sik Kim, Byung-Mu Lee
The heavy metal content of cosmetics may be a cause for concern in that exposure to these metals is associated with adverse consequences. Thus, the aim of this study was to assess consequences attributed to exposure to heavy metals in cosmetics as determined by non-cancer, cancer, and sensitization risks methodologies. The quantification and exposure assessments of aluminum (Al), chromium (Cr), manganese (Mn), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), lead (Pb), mercury (Hg), cadmium (Cd), antimony (Sb), and titanium (Ti) were performed by inductively coupled plasma-mass spectrometry...
March 28, 2018: Journal of Toxicology and Environmental Health. Part A
Arabinda Das, Anirban Biswas, Debendra Nath Guha Mazumder
Skin lesion is one of the important health hazards caused by high intake of arsenic through drinking water and diet, and the other hazards include several types of cancers (viz. skin, lung and urinary bladder), ischemic heart disease, hypertension, etc. Two most important biomarkers to measure arsenic intake in a human body are arsenic concentration in urine and hair. The primary interest of this paper is the association between skin lesion and arsenic concentration in hair for participants with chronic arsenic exposure from West Bengal, India, using bivariate regression model based on copula function...
March 26, 2018: Environmental Geochemistry and Health
Yan Xia, Xianhao Liu, Beibei Liu, Xiaoshi Zhang, Geng Tian
Liver cancer is an aggressive malignancy with a very high fatality rate. Although megestrol acetate (MA) and arsenic trioxide (ATO) have shown an antitumor effect in liver cancer cells, the therapeutic benefits of MA or ATO alone in patients with liver cancer were limited. The aim of the present study was to elucidate whether the co-treatment of MA/ATO could enhance antitumor efficacy in liver cancer cell lines (Hep G2 and BEL 7402) and explore the underlying anti-cancer mechanisms. The cell viability, apoptotic response and expression levels of associated proteins were detected by Cell Counting Kit-8 assay, flow cytometry and western blotting, respectively...
April 2018: Experimental and Therapeutic Medicine
Harinder Gill, Rita Yim, Harold K K Lee, Vivien Mak, Shek-Ying Lin, Bonnie Kho, Sze-Fai Yip, June S M Lau, Wah Li, Ho-Wan Ip, Yu-Yan Hwang, Thomas S Y Chan, Eric Tse, Wing-Yan Au, Cyrus R Kumana, Yok-Lam Kwong
BACKGROUND: For patients who have acute promyelocytic leukemia (APL) in second complete remission (CR2), optimal postremission strategies remain undefined. METHODS: The role of an oral arsenic trioxide (As2 O3 )-based regimen in the management of patients who had APL in CR2 was examined. RESULTS: Seventy-three patients with APL in first relapse (R1) were studied. Oral As2 O3 -based reinduction resulted uniformly in CR2, irrespective of previous As2 O3 exposure...
March 26, 2018: Cancer
Bahareh Toosi, Farhad Zaker, Fatemeh Alikarami, Ahmad Kazemi, Majid Teremmahi Ardestanii
Activation of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway as a survival signaling cascade is a prominent feature of cancers such as acute lymphoblastic leukemia (ALL). In patients with B-cell precursor-ALL (BCP-ALL), the high activity of the pathway correlates with the weak response to anti-leukemic drugs and relapse as a result of downstream prosurvival pathway activation, such as nuclear factor kappa B (NF-κB). Recent targeted therapy (PI3K/mTOR inhibitors) in combination with a multifunctional conventional chemotherapeutic drug may be useful for treatment of BCP-ALL patients...
March 22, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Chenan Zhang, Muhammad G Kibriya, Farzana Jasmine, Shantanu Roy, Jianjun Gao, Mekala Sabarinathan, Justin Shinkle, Dayana Delgado, Alauddin Ahmed, Tariqul Islam, Mahbubul Eunus, Md Tariqul Islam, Rabiul Hasan, Joseph H Graziano, Habibul Ahsan, Brandon L Pierce
BACKGROUND: Chronic arsenic exposure is associated with increased risk for arsenical skin lesions, cancer, and other adverse health outcomes. One potential mechanism of arsenic toxicity is telomere dysfunction. However, prior epidemiological studies of arsenic exposure, telomere length (TL), and skin lesion are small and cross-sectional. We investigated the associations between arsenic exposure and TL and between baseline TL and incident skin lesion risk among individuals participating in the Health Effects of Arsenic Longitudinal Study in Bangladesh (2000-2009)...
March 19, 2018: Environmental Research
Qingyi Tong, Huijuan You, Xintao Chen, Kongchao Wang, Weiguang Sun, Yufeng Pei, Xiaodan Zhao, Ming Yuan, Hucheng Zhu, Zengwei Luo, Yonghui Zhang
Despite All-trans retinoic acid (ATRA) has transformed acute promyelocytic leukemia (APL) from the most fatal to the most curable hematological cancer, there remains a clinical challenge that many high-risk APL patients who fail to achieve a complete molecular remission or relapse and become resistant to ATRA. Herein, we report that 5-(4-methoxyphenethyl)-[1, 3] dioxolo [4, 5-j] phenanthridin-6(5H)-one (ZYH005) exhibits specific anticancer effects on APL and ATRA-resistant APL in vitro and vivo, while shows negligible cytotoxic effect on non-cancerous cell lines and peripheral blood mononuclear cells from healthy donors...
March 15, 2018: Nucleic Acids Research
Zilong Hu, Shidong Hu, Youjun Wu, Songyan Li, Changzheng He, Xiaowei Xing, Yufeng Wang, Xiaohui Du
Although adoptive cell therapy (ACT) has demonstrated effective and remarkable clinical responses in several studies, this approach does not lead to objective clinical responses in all cases. The function of ACT is often compromised by various tumor escape mechanisms, including the accumulation of immunoregulatory cells. As a result of peritoneal metastasis in the terminal stage, malignant ascites fluid lacks effectiveness and is a poor prognostic factor for gastric cancer. The present study assessed T-cell subsets in lymphocytes derived from malignant ascites, and investigated the effects of arsenic trioxide (As2 O3 ) on regulatory T cells (Tregs) and ascites-derived tumor-infiltrating lymphocytes (TILs) in vitro ...
April 2018: Oncology Letters
Li-Ching Lin, Chi-Fen Chen, Chun-Te Ho, Jun-Jen Liu, Tsan-Zon Liu, Chi-Liang Chern
AIMS: This study uncovered that the genetically endowed intracellular glutathione contents (iGSH) regulated by the catalytic subunit of γ‑glutamylcysteine synthetase heavy chain (γ‑GCSh) as a prime target for overcoming both the inherited and stimuli-activated chemo- and radio-resistance of hepatocellular carcinoma (HCC) cells. MAIN METHODS: Reactive oxygen species (ROS) production and mitochondrial membrane potential (Δψm) were determined by the probe-based flow cytometry...
April 1, 2018: Life Sciences
Stella Koutros, Petra Lenz, Stephen M Hewitt, Masatoshi Kida, Michael Jones, Alan R Schned, Dalsu Baris, Ruth Pfeiffer, Molly Schwenn, Alison Johnson, Margaret R Karagas, Montserrat Garcia-Closas, Nathaniel Rothman, Lee E Moore, Debra T Silverman
No abstract text is available yet for this article.
March 14, 2018: Journal of the National Cancer Institute
Mona Dawood, Sami Hamdoun, Thomas Efferth
Arsenic trioxide is a traditional remedy in Chinese Medicine since ages. Nowadays, it is clinically used to treat acute promyelocytic leukemia (APL) by targeting PML/RARA. However, the drug's activity is broader and the mechanisms of action in other tumor types remain unclear. In this study, we investigated molecular modes of action by classical and network pharmacological approaches. CEM/ADR5000 resistance leukemic cells were similar sensitive to As2 O3 as their wild-type counterpart CCRF-CEM (resistance ratio: 1...
2018: Frontiers in Pharmacology
Liyin Qu, Hong Huang, Fang Xia, Yuanyuan Liu, Randy A Dahlgren, Minghua Zhang, Kun Mei
Heavy metal pollution is a major concern in China because of its serious effects on human health. To assess potential human health and ecological risks of heavy metal pollution, concentration data for seven heavy metals (As, Pb, Cd, Cr, Hg, Cu, Zn) from 14 sites spanning the rural-urban interface of the Wen-Rui Tang River watershed in southeast China were collected from 2000 to 2010. The heavy metal pollution index (HPI), hazard index (HI) and carcinogenic risk (CR) metrics were used to assess potential heavy metal risks...
March 8, 2018: Environmental Pollution
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