keyword
MENU ▼
Read by QxMD icon Read
search

arsenic + cancer

keyword
https://www.readbyqxmd.com/read/28431356/heavy-metals-pollution-levels-and-children-health-risk-assessment-of-yerevan-kindergartens-soils
#1
Gevorg Tepanosyan, Nairuhi Maghakyan, Lilit Sahakyan, Armen Saghatelyan
Children, the most vulnerable urban population group, are exceptionally sensitive to polluted environments, particularly urban soils, which can lead to adverse health effects upon exposure. In this study, the total concentrations of Ag, As, Ba, Cd, Co, Cr, Cu, Fe, Hg, Mn, Mo, Ni, Pb, Ti, V, and Zn were determined in 111 topsoil samples collected from kindergartens in Yerevan. The objectives of this study were to evaluate heavy metal pollution levels of kindergarten's soils in Yerevan, compare with national legal and international requirements on heavy metal contents in kindergarten soil, and assess related child health risk...
April 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28427227/high-dose-ascorbate-and-arsenic-trioxide-selectively-kill-acute-myeloid-leukemia-and-acute-promyelocytic-leukemia-blasts-in-vitro
#2
Nélida I Noguera, Elvira Pelosi, Daniela F Angelini, Maria Liliana Piredda, Gisella Guerrera, Eleonora Piras, Luca Battistini, Lauretta Massai, Anna Berardi, Gianfranco Catalano, Laura Cicconi, Germana Castelli, Agnese D'Angiò, Luca Pasquini, Grazia Graziani, Giuseppe Fioritoni, Maria Teresa Voso, Domenico Mastrangelo, Ugo Testa, Francesco Lo-Coco
The use of high-dose ascorbate (ASC) for the treatment of human cancer has been attempted several decades ago and has been recently revived by several in vitro and in vivo studies in solid tumors. We tested the cytotoxic effects of ASC, alone or in combination with arsenic trioxide (ATO) in acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL). Leukemic cell lines and primary blasts from AML and APL patients were treated with graded concentrations of ASC, alone or in association with standard concentration (1 μM) of ATO...
March 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423108/-potential-health-risks-from-consumption-of-water-with-arsenic-in-colima-mexico
#3
Oliver Mendoza-Cano, Ramón Alberto Sánchez-Piña, Julián Barrón-Quintana, Herguin Benjamin Cuevas-Arellano, Pilar Escalante-Minakata, Ramón Solano-Barajas
Objective: To estimate potential health risks due to chronic ingestion of arsenic from groundwater in Colima, Mexico. Materials and methods: Samples were randomly taken in 36 wells from 10 local aquifers. Analysis was performed by ICP-OES following international standards. Geostatistical interpolation was performed with ArcGIS, implementing a model weighting inverse distance to estimate arsenic routes of exposure and consumption on each locality. The Hazard Quotient Ratio (HQ) and carcinogenic risk (R) for As were estimated...
January 2017: Salud Pública de México
https://www.readbyqxmd.com/read/28419957/arsenic-in-groundwater-of-the-kolkata-municipal-corporation-kmc-india-critical-review-and-modes-of-mitigation
#4
Dipankar Chakraborti, Bhaskar Das, Mohammad Mahmudur Rahman, Bishwajit Nayak, Arup Pal, Mrinal K Sengupta, Sad Ahamed, Md Amir Hossain, Uttam K Chowdhury, Bhajan Kumar Biswas, Khitish Chandra Saha, R N Dutta
This study represents the first comprehensive report of groundwater arsenic contamination status in the Kolkata Municipal Corporation (KMC). During the past 23 years, 4210 groundwater samples were analysed from all 141 wards in the KMC: 14.2% and 5.2% samples had arsenic >10 μg/l and >50 μg/l, respectively, representing 77 and 37 wards. The study shows that the number of arsenic contaminated samples (and wards) in the southern part of the KMC exceeds that of other parts of the city. The daily intake of arsenic from drinking water was estimated as 0...
April 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/28418774/arsenic-in-the-groundwater-occurrence-toxicological-activities-and-remedies
#5
S K Jha, V K Mishra, T Damodaran, D K Sharma, Parveen Kumar
Arsenic (As) contamination in groundwater has become a geo-environmental as well as a toxicological problem across the globe affecting more than 100-million people in nearly 21 countries with its associated disease "arsenicosis." Arsenic poisoning may lead to fatal skin and internal cancers. In present review, an attempt has been made to generate awareness among the readers about various sources of occurrence of arsenic, its geochemistry and speciation, mobilization, metabolism, genotoxicity, and toxicological exposure on humans...
February 22, 2017: Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
https://www.readbyqxmd.com/read/28410574/comparison-of-different-cell-type-correction-methods-for-genome-scale-epigenetics-studies
#6
COMPARATIVE STUDY
Akhilesh Kaushal, Hongmei Zhang, Wilfried J J Karmaus, Meredith Ray, Mylin A Torres, Alicia K Smith, Shu-Li Wang
BACKGROUND: Whole blood is frequently utilized in genome-wide association studies of DNA methylation patterns in relation to environmental exposures or clinical outcomes. These associations can be confounded by cellular heterogeneity. Algorithms have been developed to measure or adjust for this heterogeneity, and some have been compared in the literature. However, with new methods available, it is unknown whether the findings will be consistent, if not which method(s) perform better. RESULTS: Methods: We compared eight cell-type correction methods including the method in the minfi R package, the method by Houseman et al...
April 14, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28365685/-epigallocatechin-3-gallate-inhibits-arsenic-induced-inflammation-and-apoptosis-through-suppression-of-oxidative-stress-in-mice
#7
Nan-Hui Yu, Haiping Pei, Yong-Pan Huang, Yu-Fei Li
BACKGROUND/AIMS: Exposure to arsenic in individuals has been found to be associated with various health-related problems including skin lesions, cancer, and cardiovascular and immunological disorders. (-)-Epigallocatechin-3-gallate (EGCG), the main and active polyphenolic catechin present in green tea, has shown potent antioxidant, anti-apoptotic and anti-inflammatory activity in vivo and in vitro. Thus, the present study was conducted to investigate the protective effects of EGCG against arsenic-induced inflammation and immunotoxicity in mice...
April 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28337271/effects-of-long-term-low-and-high-dose-sodium-arsenite-exposure-in-human-transitional-cells
#8
Jianming He, Feng Wang, Fen Luo, Xuedan Chen, Xi Liang, Wenbin Jiang, Zhizhong Huang, Jiafan Lei, Fabo Shan, Xueqing Xu
Epidemiological studies have revealed the association between increased risk of bladder cancer and chronic arsenic exposure. Here, we explored biological effects of arsenic in T24. Microarray analysis was applied to analyze mRNA in T24 following 0, 2 or 5 μM sodium arsenite (As) exposure for 72 hours. Long term (up to 140 days) low-dose (200 nM) and high-dose (1,000 nM) As decreased E-cadherin protein level through different mechanisms because the mRNA levels of E-cadherin increased following low-dose As exposure but decreased following high-dose As exposure...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28332085/low-level-arsenic-causes-chronic-inflammation-and-suppresses-expression-of-phagocytic-receptors
#9
Priyanka Prasad, Dona Sinha
The impact of chronic low-level groundwater arsenic (As) exposure [in the range above the WHO-recommended limit of 10 μg/L but ≤50 μg/L (permissible limit of As for many Asian countries)] was investigated for cross talk of inflammatory changes and expression of phagocytic receptors of exposed rural women (N, 45) from districts of 24 Parganas (south) and in matched control groups (N, 43) [As ≤10 μg/L] from the same district. Systemic inflammation was evident from the upregulated levels of pro-inflammatory mediators like tumor necrosis factor-α (TNF-α); interleukins (ILs) like IL-6, IL-8, and IL-12; and C-reactive protein (CRP) in the sera and upregulated expression of protein kinase B phosphorylated at ser473 (pAKTser473)/nuclear factor-κB (NF-κB)/TNF-α axis in the leukocytes of exposed women with respect to control...
March 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28329540/acral-keratoses-and-squamous-cell-carcinomas-likely-associated-with-arsenic-exposure
#10
Amelia K Hausauer, Rachel Hoffmann, Vitaly Terushkin, Shane A Meehan, Alisa N Femia, Miriam Keltz Pomeranz
Chronic arsenic exposure is known to inducepunctate keratoses with an increased risk ofprimary squamous-cell carcinoma. Drinking wateris currently the major source of arsenic exposureworldwide and is considered one of the mostsubstantial environmental carcinogens. We describethe case of a 61-year-old Hungarian woman withscattered, acral, hyperkeratotic papules and a historyof five palmoplantar squamous-cell carcinomasas well as two other extremity non-melanomaskin cancers. Prior to immigration, she had livedin a county of Southern Hungary that is known tohave elevated concentrations of inorganic arsenicin the drinking water above the World HealthOrganization's current maximum threshold forsafety...
December 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28322969/arsenic-cadmium-mercury-sodium-and-potassium-concentrations-in-common-foods-and-estimated-daily-intake-of-the-population-in-valdivia-chile-using-a-total-diet-study
#11
Ociel Muñoz, Pedro Zamorano, Olga Garcia, José Miguel Bastías
This study was designed to estimate the dietary intake of total arsenic, inorganic arsenic, cadmium, mercury, sodium, and potassium by the general adult population (aged 18-65) of Valdivia, Chile. Calculations were based on a 24-h dietary recall survey. The highest dietary intake of t-As (73.0 μg/day), i-As (20.0 μg/day), Cd (18.0 μg/day), Hg (5.8 μg/day), Na(+) (3112.8 mg/day), and K(+) (2077.5 mg/day) were for 70-kg adults. Estimating carcinogenic risk (CR > 4 × 10(-4)) due to exposure to i-As indicated that consumers remain at low risk for cancer...
March 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28318385/arsenic-induced-sumoylation-of-mus81-is-involved-in-regulating-genomic-stability
#12
Liyan Hu, Feikun Yang, Lou Lu, Wei Dai
Chronic environmental exposure to metal toxicants such as chromium and arsenic is closely related to the development of several types of common cancers. Genetic and epigenetic studies in the past decade reveal that post-translational modifications of histones play a role in metal carcinogenesis. However, exact molecular mechanisms of metal carcinogenesis remain to be elucidated. In this study we found that As2O3, an environmental metal toxicant, upregulated overall modifications of many cellular proteins by SUMO2/3...
April 18, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28316232/in-vitro-reduction-of-arsenic-bioavailability-using-dietary-strategies
#13
M J Clemente, V Devesa, D Velez
The main route of human exposure to inorganic arsenic (As) is through consumption of food and water. Continued exposure to inorganic As [As(III) and As(V)] may cause a variety of diseases, including various types of cancer. Removal of As from these sources is complex, especially for food. One way to decrease As exposure could be by reducing intestinal absorption of it. The aim of this study is to seek dietary strategies (pure compounds, extracts, or supplements) that are capable of reducing the amount of As that is absorbed and reaches the systemic circulation...
March 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28299819/arsenic-trioxide-combined-with-transarterial-chemoembolization-for-primary-liver-cancer-a-meta-analysis
#14
Xiu-He Lv, Chun-Hui Wang, Yan Xie
BACKGROUND: The benefit of combination therapy of arsenic trioxide (As2 O3 ) and transarterial chemoembolization (TACE) is debated. This meta-analysis was conducted to determine whether As2 O3 & TACE therapy achieves better therapeutic effects compared with TACE alone for primary liver cancer. METHODS: A systematic search of both English and Chinese databases was conducted for randomised controlled trials (RCTs). The main outcomes were therapeutic responses, survival rates, improvement in quality of life, and adverse events...
March 15, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28287256/label-free-and-homogenous-detection-of-caspase-3-like-proteases-by-disrupting-homodimerization-directed-bipartite-tetracysteine-display
#15
Yong Yang, Yan Liang, Chun-Yang Zhang
Caspase-3-like proteases (e.g., caspase-3 and caspase-7) constitute the core players of cell apoptosis, and their dysregulation has been linked to a number of human diseases, such as cancer and neurodegenerative disorders. However, the methods for measuring caspase-3-like proteases are often complex and time-consuming. Herein, we develop a label-free method to homogeneously detect caspase-3-like proteases in vitro and in complex cell lysate. This assay uses a modular peptide that contains a dimerization domain, a caspase-3/7 cleavage sequence, and a dicysteine motif as the activity sensor to detect caspase-3-like proteases...
March 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28284039/arsenic-and-breast-cancer-a-systematic-review-of-epidemiologic-studies
#16
Narges Khanjani, Abu-Bakr Jafarnejad, Leila Tavakkoli
INTRODUCTION: Arsenic is one of the heavy metals known to be a cause of cancer and many other serious human health problems. The International Agency for Research on Cancer (IARC), has classified arsenic as a Group 1 carcinogen. Studies were performed in different populations to investigate the association between arsenic and breast cancer and the present paper attempts to review these studies. METHODS AND MATERIALS: Accessible electronic resources including, PubMed, Web of Knowledge, Science Direct and Scopus and Google Scholar were searched, with relevant phrases up to October 30, 2016...
March 11, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28273826/metal-exposure-and-associated-health-risk-to-human-beings-by-street-dust-in-a-heavily-industrialized-city-of-hunan-province-central-china
#17
Guangyi Sun, Zhonggen Li, Ting Liu, Ji Chen, Tingting Wu, Xinbin Feng
Fifty-five urban street dust samples were collected from Zhuzhou, an industrial city in central China and analyzed for a range of toxic elements. Potential carcinogenic and non-carcinogenic health effects on children and adults due to exposure to street dust were assessed. Concerning the two subgroups, the child cohort is confronted with considerably greater health risks than adults. According to the Hazard Quotient (HQ) method, ingestion of dust particles poses primary risk to children and adults, followed by dermal contact and inhalation for all of the metals investigated except Hg, for which inhalation of its elemental vapor constitute a slightly higher risk than ingestion...
March 3, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28270149/chronic-exposure-to-arsenic-line-1-hypomethylation-and-blood-pressure-a-cross-sectional-study-in-bangladesh
#18
Khaled Hossain, Takehiro Suzuki, M M Hasibuzzaman, Md Shofikul Islam, Atiqur Rahman, Sudip Kumar Paul, Tanzina Tanu, Shakhawoat Hossain, Zahangir Alam Saud, Mashiur Rahman, Farjana Nikkon, Hideki Miyataka, Seiichiro Himeno, Keiko Nohara
BACKGROUND: Chronic exposure to arsenic is associated with cancer and hypertension. Growing evidence suggests that altered methylation in long interspersed nuclear element-1 (LINE-1) is involved in many types of disorders, including cardiovascular disease. Here we evaluated the association between arsenic exposure and LINE-1 methylation levels, especially in relation to blood pressure (BP). METHODS: A total of 236 subjects (175 from arsenic-endemic areas and 61 from a non-endemic area) in rural Bangladesh were recruited...
March 7, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28265304/tumor-augmenting-effects-of-gestational-arsenic-exposure-on-f1-and-f2-in-mice
#19
REVIEW
Keiko Nohara, Takehiro Suzuki, Kazuyuki Okamura, Junya Matsushita, Shota Takumi
The consequences of early-life exposure to chemicals in the environment are emerging concerns. Chronic exposure to naturally occurring inorganic arsenic has been known to cause various adverse health effects, including cancers, in humans. On the other hand, animal studies by Dr. M. Waalkes' group reported that arsenite exposure of pregnant F0 females, only from gestational day 8 to 18, increased hepatic tumors in the F1 (arsenite-F1) males of C3H mice, whose males tend to develop spontaneous hepatic tumors later in life...
2017: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/28265077/arsenic-trioxide-targets-mthfd1-and-sumo-dependent-nuclear-de-novo-thymidylate-biosynthesis
#20
Elena Kamynina, Erica R Lachenauer, Aislyn C DiRisio, Rebecca P Liebenthal, Martha S Field, Patrick J Stover
Arsenic exposure increases risk for cancers and is teratogenic in animal models. Here we demonstrate that small ubiquitin-like modifier (SUMO)- and folate-dependent nuclear de novo thymidylate (dTMP) biosynthesis is a sensitive target of arsenic trioxide (As2O3), leading to uracil misincorporation into DNA and genome instability. Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and serine hydroxymethyltransferase (SHMT) generate 5,10-methylenetetrahydrofolate for de novo dTMP biosynthesis and translocate to the nucleus during S-phase, where they form a multienzyme complex with thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR), as well as the components of the DNA replication machinery...
March 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
keyword
keyword
104900
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"