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arsenic + cancer

Anna Nilsson, Cecilia Johansson, Astrid Skarp, René Kaden, Lars Engstrand, Hilpi Rautelin
Campylobacter jejuni is the most common cause of bacterial gastroenteritis. Major reservoirs are warm-blooded animals, poultry in particular, but Campylobacter can also be transmitted via water. In this paper, we have taken a closer look at the biology and potential virulence of C. jejuni water isolates. Seven C. jejuni isolates from incoming surface water at water plants in Sweden were characterized with whole genome sequencing and phenotypical testing. Multi locus sequence typing analysis revealed that these isolates belonged to groups known to include both common (ST48CC) and uncommon (ST1275CC, ST683, ST793 and ST8853) human pathogens...
2017: PloS One
Erika B Dugo, Clement G Yedjou, Jacqueline J Stevens, Paul B Tchounwou
Hepatocellular carcinoma (HCC), the dominant form of primary liver cancer, is the sixth most common cancer in the world with more than 700,000 people diagnosed annually. Arsenic trioxide (ATO) has been shown to be a potent anticancer agent in various carcinomas, proving particularly effective in the clinical treatment of relapsed and refractory acute promyelocytic leukemia. However, its bioactivity and molecular mechanisms against HCC has not been fully studied. Using human HCC (HepG2) cells as a test model, we studied the effects of ATO and examined the role of oxidative stress (OS) and apoptosis in cytotoxicity...
2017: Annals of Clinical Pathology
Xuhua Duan, Tengfei Li, Xinwei Han, Jianzhuang Ren, Pengfei Chen, Hao Li, Shaojun Gong
High concentrations of arsenic trioxide (As2O3) are used to treat acute promyelocytic leukemia and solid tumors, with negative side effects to normal cells. Andrographolide is a traditional Chinese medicine that exerts anti-cancer, anti-inflammatory, anti-virus, and anti-diabetic effects. Here, we tested the effects of combined andrographolide with As2O3 against hepatocellular carcinoma (HCC). We found that by increasing apoptosis, andrographolide synergistically enhanced the anti-tumor effects of As2O3 in HepG2 cells in vitro and in vivo...
October 31, 2017: Oncotarget
Alain Aguirre-Vázquez, Adriana Sampayo-Reyes, Laura González-Escalante, Alba Hernández, Ricard Marcos, Fabiola Castorena-Torres, Gerardo Lozano-Garza, Reyes Taméz-Guerra, Mario Bermúdez de León
Arsenic is a worldwide environmental pollutant that generates public health concerns. Various types of cancers and other diseases, including neurological disorders, have been associated with human consumption of arsenic in drinking water. At the molecular level, arsenic and its metabolites have the capacity to provoke genome instability, causing altered expression of genes. One such target of arsenic is the Pax6 gene that encodes a transcription factor in neuronal cells. The aim of this study was to evaluate the effect of two antioxidants, α-tocopheryl succinate (α-TOS) and sodium selenite, on Pax6 gene expression levels in the forebrain and cerebellum of Golden Syrian hamsters chronically exposed to arsenic in drinking water...
December 5, 2017: Acta Biochimica Polonica
Hugues de Thé
The concept of differentiation therapy emerged from the fact that hormones or cytokines may promote differentiation ex vivo, thereby irreversibly changing the phenotype of cancer cells. Its hallmark success has been the treatment of acute promyelocytic leukaemia (APL), a condition that is now highly curable by the combination of retinoic acid (RA) and arsenic. Recently, drugs that trigger differentiation in a variety of primary tumour cells have been identified, suggesting that they are clinically useful. This Opinion article analyses the basis for the clinical successes of RA or arsenic in APL by assessing the respective roles of terminal maturation and loss of self-renewal...
December 1, 2017: Nature Reviews. Cancer
Young-Seoub Hong, Byeong-Jin Ye, Yu-Mi Kim, Byoung-Gwon Kim, Gyeong-Hui Kang, Jeong-Jin Kim, Ki-Hoon Song, Young-Hun Kim, Jeong-Wook Seo
Recent epidemiological studies have reported adverse health effects, including skin cancer, due to low concentrations of arsenic via drinking water. We conducted a study to assess whether low arsenic contaminated ground water affected health of the residents who consumed it. For precise biomonitoring results, the inorganic (trivalent arsenite (As III) and pentavalent arsenate (As V)) and organic forms (monomethylarsonate (MMA) and dimethylarsinate (DMA)) of arsenic were separately quantified by combining high-performance liquid chromatography and inductively coupled plasma mass spectroscopy from urine samples...
November 27, 2017: International Journal of Environmental Research and Public Health
Abha Sharma, S J S Flora
Consumption of arsenic contaminated water causes serious skin disease and cancer in a significant number of exposed people. Chelating agents, consider an expensive therapy, are employed in the treatment of arsenic intoxication. There are reports which suggest that the poorest suffer the most from arsenicosis. This may be due to improper diet intake, consist of low protein and micronutrients which increase the vulnerability to arsenic-related disorders. Several human studies demonstrated the associations between malnourishment and the development of arsenic-caused skin lesions, skin cancer and cardiovascular effects...
January 2018: Journal of Trace Elements in Medicine and Biology
A K M Atique Ullah, M A Maksud, S R Khan, L N Lutfa, Shamshad B Quraishi
Concentrations of five heavy metals (Pb, Cd, Cr, As and Hg) in eight highly consumed cultured fish species (Labeo rohita, Clarias gariepinus, Hypophthalmichthys molitrix, Cyprinus capio, Puntius sarana, Oreochromis mossambicus, Pangasius pangasius and Anabas testudineus) collected from four wholesale markets of Dhaka city, Bangladesh (Karwan Bazar, Mohammadpur Town Hall, Newmarket and Mirpur-1) were measured using atomic absorption spectrometry (AAS) in order to evaluate the potential human health risks from the consumption of fish...
2017: Toxicology Reports
Feng Zhang, Chun-Mei Zhang, Shu Li, Kun-Kun Wang, Bin-Bin Guo, Yao Fu, Lu-Yang Liu, Yu Zhang, Hai-Yu Jiang, Chang-Jun Wu
Hepatoblastoma (HB) is the most common type of pediatric liver malignancy, which predominantly occurs in young children (aged <5 years), and continues to be a therapeutic challenge in terms of metastasis and drug resistance. As a new pattern of tumor blood supply, vasculogenic mimicry (VM) is a channel structure lined by tumor cells rather than endothelial cells, which contribute to angiogenesis. VM occurs in a variety of solid tumor types, including liver cancer, such as hepatocellular carcinoma. The aim of the present study was to elucidate the effect of arsenic trioxide (As2O3) on VM...
November 14, 2017: Molecular Medicine Reports
Yuting Zhou, Lili Niu, Kai Liu, Shanshan Yin, Weiping Liu
Arsenic (As) in the environment is of concern due to its strong toxicity and high risks to the ecosystems and humans. In this study, soil samples across China collected in 2011 and 2016 were used to determine the concentrations of arsenic in arable soils. The median concentration of arsenic in surface soils was 9.7mg/kg. The inventory of arsenic in the Chinese agricultural surface soils was estimated to be 3.7×10(6)tons. In general, arsenic contamination was found higher in South and Northeast China than in other regions, with means of 18...
November 4, 2017: Science of the Total Environment
Mac Gifford, Mikhail Chester, Kiril Hristovski, Paul Westerhoff
Treatment of drinking water decreases human health risks by reducing pollutants, but the required materials, chemicals, and energy emit pollutants and increase health risks. We explored human carcinogenic and non-carcinogenic disease tradeoffs of water treatment by comparing pollutant dose-response curves against life cycle burden using USEtox methodology. An illustrative wellhead sorbent groundwater treatment system removing hexavalent chromium or pentavalent arsenic serving 3200 people was studied. Reducing pollutant concentrations in drinking water from 20 μg L-1 to 10 μg L-1 avoided 37 potential cancer cases and 64 potential non-cancer disease cases...
October 9, 2017: Water Research
Wei-Ting Liao, Huey-Ling You, Chee-Yin Chai, Chih-Hung Lee, Cheng-Che E Lan, Shun-Jen Chang, Chu-Ling Yu, Hsin-Su Yu
BACKGROUND: Patients with arsenic-induced Bowen's disease (As-BD) are at risk of developing invasive cancers in the skin, lung, and urinary bladder. However, a longitudinal follow-up study on the association between As-BD and invasive cancers is still lacking. OBJECTIVES: This study aims to investigate the underlying molecular mechanisms of this malignant progression in the skin and internal organs. METHODS: This is a biopsy-based follow-up study...
October 31, 2017: Journal of Dermatological Science
Sunbin Ling, Qiaonan Shan, Peng Liu, Tingting Feng, Xuanyu Zhang, Penghui Xiang, Kangchen Chen, Haiyang Xie, Penghong Song, Lin Zhou, Jimin Liu, Shusen Zheng, Xiao Xu
Arsenic trioxide (ATO) is a well-accepted chemotherapy agent in managing promyelocytic leukemia. ATO often causes severe health hazards such as hepatotoxicity, dermatosis, neurotoxicity, nephrotoxicity and cardiotoxicity. The production of reactive oxygen species, (ROS) play a significant role in ATO-induced hepatotoxicity. The oral hypoglycemic drug, metformin, is considered to be a potential novel agent for chemoprevention in the treatment of cancer. Moreover, metformin has also been shown to have hepatoprotective effects...
November 2, 2017: Cell Death & Disease
Supanad Hensawang, Penradee Chanpiwat
Consumption of contaminated food is a major route of exposure to toxic contaminants for humans. To protect against potential negative health effects from rice consumption, As and Cd concentrations in rice sold in Bangkok were determined, and non-carcinogenic and carcinogenic risk assessments were conducted. Four types of rice (n = 97), namely, white jasmine, white, glutinous, and brown jasmine, were collected. Samples were acid-digested and analyzed for total concentrations of As and Cd by ICP-MS. The average concentrations of As and Cd were 0...
October 31, 2017: Environmental Monitoring and Assessment
Nathalie Saint-Jacques, Patrick Brown, Laura Nauta, James Boxall, Louise Parker, Trevor J B Dummer
Arsenic in drinking water impacts health. Highest levels of arsenic have been historically observed in Taiwan and Bangladesh but the contaminant has been affecting the health of people globally. Strong associations have been confirmed between exposure to high-levels of arsenic in drinking water and a wide range of diseases, including cancer. However, at lower levels of exposure, especially near the current World Health Organization regulatory limit (10μg/L), this association is inconsistent as the effects are mostly extrapolated from high exposure studies...
January 2018: Environment International
H N Lynch, K Zu, E M Kennedy, T Lam, X Liu, D M Pizzurro, C T Loftus, L R Rhomberg
No abstract text is available yet for this article.
December 2017: Environment International
Haitao Yang, Sijing Zhou, Ruifen Shen, Shuimei Luo, Lina Li, Heng Lin, Huijuan Chen, Ziyuan Liao, Wanzun Lin, Xianhe Xie
Currently, some clinical trials of arsenic trioxide (As203) plus transcatheter arterial chemoembolization (TACE) in the treatment of unresectable primary liver cancer (PLC) had been conducted, but the results were controversial. Therefore, we performed a meta-analysis on 14 clinical trials (1076 cases) to evaluate efficacy and safety of As203 plus TACE versus TACE alone for unresectable PLC. The primary end points included objective response rate (ORR), karnofsky performance score (KPS) improvement rate, and 1-year survival rate...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Allan H Smith, Guillermo Marshall, Taehyun Roh, Catterina Ferreccio, Jane Liaw, Craig Steinmaus
Background: Region II in northern Chile (population 442 570) experienced a sudden major increase in arsenic water concentrations in 1958 in the main city of Antofagasta, followed by a major reduction in exposure when an arsenic removal plant was installed in 1970. It provides a unique opportunity to study latency effects of exposure to arsenic, and this is the first study with mortality data up to 40 years after exposure reduction. Methods: We previously identified high mortality rates in Region II up to the year 2000...
October 24, 2017: Journal of the National Cancer Institute
Alexandra Muñoz, Will J Eldridge, Nina Munkholt Jakobsen, Helle Sørensen, Adam Wax, Max Costa
Cancer cells consistently exhibit decreased stiffness, however the onset and progression of this change has not been characterized. To study the development of cell stiffness changes we evaluated the shear stiffness of populations of cells during transformation to a carcinogenic state. Bronchial epithelial cells were exposed to sodium arsenite to initiate early stages of transformation. Exposed cells were cultured in soft agar to further transformation and select for clonal populations exhibiting anchorage independent growth...
October 24, 2017: Carcinogenesis
Yu Fan, Tingping Zhu, Mengtong Li, Jieyi He, Ruixue Huang
BACKGROUND: Metal mining and waste discharge lead to regional heavy metal contamination and attract major concern because of the potential risk to local residents. METHODS: This research was conducted to determine lead (Pb), cadmium (Cd), arsenic (As), manganese (Mn), and antimony (Sb) concentrations in soil and brown rice samples from three heavy metal mining areas in Hunan Province, central China, and to assess the potential health risks to local inhabitants. RESULTS: Local soil contamination was observed, with mean concentrations of Cd, Pb, Sb, and As of 0...
2017: Journal of Healthcare Engineering
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