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https://www.readbyqxmd.com/read/28525936/heavy-metal-and-arsenic-concentrations-in-rainbow-trout-oncorhynchus-mykiss-farmed-in-a-dam-reservoir-on-the-firat-euphrates-river-risk-based-consumption-advisories
#1
Memet Varol, Gülderen Kurt Kaya, Alper Alp
The concentrations of ten metals in rainbow trout (Oncorhynchus mykiss) farmed in the Karakaya Dam Reservoir (Turkey) on the Firat River were determined. The metal concentrations in rainbow trout did not exceed the maximum permissible levels. Biomagnification factors (BMF) of ten metals were <1, indicating that these metals were not biomagnified. The estimated daily intake (EDI) of each metal was much lower than the respective tolerable daily intake (TDI). The target hazard quotient (THQ) for individual metal and total THQ for combined metals were lower than 1, indicating no health risk for consumers due to the intake of either individual metal or combined metals...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28524356/association-between-yap-expression-in-neoplastic-and-non-neoplastic-breast-tissue-with-arsenic-urinary-levels
#2
Gladis Michel-Ramirez, Rogelio Recio-Vega, Guadalupe Ocampo-Gomez, Eduardo Palacios-Sanchez, Manuel Delgado-Macias, Manuel Delgado-Gaona, Robert Clark Lantz, Jay Gandolfi, Tania Gonzalez-Cortes
The Hippo pathway regulates cell proliferation and apoptosis and it has been noted that loss of critical components of this pathway can lead to uncontrolled cell growth. Yes-associated protein (YAP) is an important component of this Hippo pathway because YAP is the nuclear effector of the Hippo tumor suppressor pathway and it is crucial for the response to oxidative stress induced by cellular process and by different xenobiotics, including arsenic. It has been proposed that YAP dysregulation can contribute to a malignant cellular phenotype acting as both a tumor suppressor and an oncogene...
May 19, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28521962/the-functional-roles-of-pml-nuclear-bodies-in-genome-maintenance
#3
REVIEW
Hae Ryung Chang, Anudari Munkhjargal, Myung-Jin Kim, Seon Young Park, Eunyoung Jung, Jae-Ha Ryu, Young Yang, Jong-Seok Lim, Yonghwan Kim
In the nucleus, there are several membraneless structures called nuclear bodies. Among them, promyelocytic leukemia nuclear bodies (PML-NBs) are involved in multiple genome maintenance pathways including the DNA damage response, DNA repair, telomere homeostasis, and p53-associated apoptosis. In response to DNA damage, PML-NBs are coalesced and divided by a fission mechanism, thus increasing their number. PML-NBs also play a role in repairing DNA double-strand breaks (DSBs) by homologous recombination (HR). Clinically, the dominant negative PML-RARα fusion protein expressed in acute promyelocytic leukemia (APL) inhibits the transactivation of downstream factors and disrupts PML function, revealing the tumor suppressor role of PML-NBs...
May 5, 2017: Mutation Research
https://www.readbyqxmd.com/read/28516305/arsenic-toxicity-and-epimutagenecity-the-new-lineage
#4
REVIEW
Somnath Paul, Pritha Bhattacharjee, Ashok K Giri, Pritha Bhattacharjee
Global methylation pattern regulates the normal functioning of a cell. Research have shown arsenic alter these methylation landscapes within the genome leading to aberrant gene expression and inducts various pathophysiological outcomes. Long interspersed nuclear elements (LINE-1) normally remains inert due to heavy methylation of it's promoters, time and various environmental insults, they lose these methylation signatures and begin retro-transposition that has been associated with genomic instability and cancerous outcomes...
May 17, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28501332/inhibition-of-nicotinamide-phosphoribosyltransferase-and-depletion-of-nicotinamide-adenine-dinucleotide-contribute-to-arsenic-trioxide-suppression-of-oral-squamous-cell-carcinoma
#5
Xin Yue Wang, Jin Zhi Wang, Lu Gao, Fu Yin Zhang, Qi Wang, Ke Jian Liu, Bin Xiang
Emerging evidence suggests that increased nicotinamide phosphoribosyltransferase (NAMPT) expression is associated with the development and prognosis of many cancers, but it remains unknown regarding its role in oral squamous cell carcinoma (OSCC). In the present study, the results from tissue microarray showed that NAMPT was overexpressed in OSCC patients and its expression level was directly correlated with differential grades of cancer. Interestingly, treatment of OSCC cells with chemotherapy agent arsenic trioxide (ATO) decreased the levels of NAMPT protein and increased cellular death in an ATO dose- and time-dependent manner...
May 10, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28484874/effects-of-arsenic-toxicity-beyond-epigenetic-modifications
#6
REVIEW
Geir Bjørklund, Jan Aaseth, Salvatore Chirumbolo, Mauricio A Urbina, Riaz Uddin
Worldwide chronic arsenic (As) poisoning by arsenic-contaminated groundwater is one of the most threatening public health problems. Chronic inorganic As (inAs) exposure has been associated with various forms of cancers and numerous other pathological effects in humans, collectively known as arsenicosis. Over the past decade, evidence indicated that As-induced epigenetic modifications have a role in the adverse effects on human health. The main objective of this article is to review the evidence on epigenetic modifications induced by arsenicals...
May 8, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28480809/sodium-meta-arsenite-induced-reactive-oxygen-species-in-human-red-blood-cells-impaired-antioxidant-and-membrane-redox-systems-haemoglobin-oxidation-and-morphological-changes
#7
Nikhil Maheshwari, Fahim Halim Khan, Riaz Mahmood
Arsenic (As) is an air and water toxicant that causes cancer in multiple organs. Humans are exposed to arsenic through contaminated water. We have examined the cytotoxicity of sodium meta-arsenite (SA), an As(III) compound, in human red blood cells (RBC) under in vitro conditions. Hemolysates were prepared from human RBC treated with different concentrations of SA (0.1 to 5.0 mM) for 5 h at 37°C. SA treatment of RBC caused significant increase in methemoglobin formation, protein and lipid oxidation and nitric oxide levels...
May 7, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28477019/nfatc3-mediates-the-sensitivity-of-gastric-cancer-cells-to-arsenic-sulfide
#8
Xiuli Zhang, Ting Kang, Lian Zhang, Yingying Tong, Wenping Ding, Siyu Chen
Arsenic sulfide (As4S4) is the main component of Realgar which is widely used in traditional Chinese medicine. Previously we showed that As4S4 inhibited the proliferation of colon cancer cells through regulating nuclear factor of activated T cells (NFAT) pathway. Here we explore the role of NFAT in gastric cancer. We showed that As4S4 inhibited the expression of NFATc1, NFATc3, and NFATc4, and modulated the expression of NFATc2 accompanying with p53. The baseline expression of NFATc3 varied distinctly in gastric cancer cell lines (AGS, MGC803, MKN28, MKN45, and SGC7901) and the sensitivity of these cells to As4S4 was dissimilar, with AGS and MGC803 cells showing higher sensitivity while the SGC7901 cells relatively resistant...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28472268/nickel-induces-transcriptional-down-regulation-of-dna-repair-pathways-in-tumorigenic-and-non-tumorigenic-lung-cells
#9
Susan E Scanlon, Christine D Scanlon, Denise C Hegan, Parker L Sulkowski, Peter M Glazer
The heavy metal nickel is a known carcinogen, and occupational exposure to nickel compounds has been implicated in human lung and nasal cancers. Unlike many other environmental carcinogens, however, nickel does not directly induce DNA mutagenesis, and the mechanism of nickel-related carcinogenesis remains incompletely understood. Cellular nickel exposure leads to signaling pathway activation, transcriptional changes, and epigenetic remodeling, processes also impacted by hypoxia, which itself promotes tumor growth without causing direct DNA damage...
May 2, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28470574/tff3-expression-as-stratification-marker-in-borderline-epithelial-tumors-of-the-ovary
#10
Ahmed El-Balat, Iryna Schmeil, Thomas Karn, Sven Becker, Nicole Sänger, Uwe Holtrich, Ruza Arsenic
Borderline tumors (BOT) of the ovary account for 10% to 20% of ovarian neoplasms. Like ovarian cancer, BOT encompass several different histological subtypes (serous, mucinous, endometrioid, clear cell, transitional cell and mixed) with serous (SBOT) and mucinous (MBOT) the most common. Current hypotheses suggest low-grade serous carcinoma may develop in a stepwise fashion from SBOT whereas the majority of high grade serous carcinomas develop rapidly presumably from inclusion cysts or ovarian surface epithelium...
May 3, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28467781/extracellular-signal-regulated-kinase-8-mediated-nf-%C3%AE%C2%BAb-activation-increases-sensitivity-of-human-lung-cancer-cells-to-arsenic-trioxide
#11
Dan-Dan Wu, Andy T Y Lau, Fei-Yuan Yu, Na-Li Cai, Li-Juan Dai, Myoung Ok Kim, Dong-Yan Jin, Yan-Ming Xu
Extracellular signal-regulated kinase 8 (ERK8), also known as mitogen-activated protein kinase 15 (MAPK15), is the most recently identified protein kinase of the ERK family members and yet the least has been studied so far. Here, we report that ERK8 is highly expressed in several human lung cancer cell lines and is positively correlated with their sensitivities to the anti-cancer drug arsenic trioxide (As2O3). As2O3 at physiologically relevant concentrations (5-20 μM) potently stimulates the phosphorylation of ERK8 at Thr175 and Tyr177 within the TEY motif in the kinase domain, leading to its activation...
April 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28459147/synergistic-effects-of-arsenic-trioxide-and-radiation-triggering-of-intrinsic-pathway-of-apoptosis
#12
Kave Moloudi, Ali Neshasteriz, Arshad Hosseini, Nazila Eyvazzadeh, Mehdi Shomali, Samira Eynali, Elahe Mirzaei, Asaad Azarnezhad
Background: Arsenic trioxide (ATO) has been reported as an effective anti-cancer and a US Food and Drug Administration (FDA) approved drug for treatment of some cancers. The aim of this study is to determine the underlying apoptosis molecular and cellular mechanisms of ATO in the presence or absence of ionizing radiation (IR) in vitro in the glioblastoma multiforme (GBM) cell line, U87MG. Methods: Cells were treated by different concentrations of ATO either in presence or absence of IR...
May 1, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28454374/arsenic-trioxide-inhibits-tumor-induced-myeloid-derived-suppressor-cells-and-enhances-t-cell-activity
#13
Qingmin Gao, Jingwei Jiang, Zhaohui Chu, Hao Lin, Xinli Zhou, Xiaohua Liang
Myeloid-derived suppressor cells (MDSCs), one of the major orchestrators of the immunosuppressive network, are associated with immune suppression and considered a prime target for cancer immunotherapy. At present, various strategies have been explored to deplete and/or inactivate MDSCs in vivo. In this study, we investigated the effect of arsenic trioxide (ATO) on MDSCs derived from tumor-bearing mice. This study examined the in vitro and in vivo effects of ATO administration on MDSCs from C57/j mice bearing either the B16 or H22 tumor...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28451559/effect-of-sodium-arsenite-on-the-expression-of-antioxidant-genes-sod2-and-cat-in-mcf-7-and-jurkat-cell-lines
#14
Leila Fallahzadeh-Abarghooei, Maryam Samadaei-Ghadikolaie, Iraj Saadat, Mostafa Saadat
BACKGROUND: Sodium arsenite (NaAsO2) has potent cytotoxic activity in human cancer cells. Oxidative stress has been suggested as a mechanism for arsenic-induced carcinogenesis. The purpose of the present study was to evaluate the alteration of mRNA levels of catalase (CAT) and superoxide dismutase 2 (SOD2) in MCF-7 and Jurkat cells after exposure to NaAsO2. METHODS: Methylthiazol tetrazolium (MTT) viability assay was performed to evaluate cytotoxicity of NaAsO2 in MCF-7 and Jurkat cells...
February 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28444938/low-concentration-arsenite-activated-jak2-stat3-signal-and-increased-proliferative-factor-expressions-in-sv-huc-1cells-after-short-and-long-time-treatment
#15
Li Mengdan, Wang Chen, Liu Jieyu, Jin Peiyu, Wang Fei, Liu Shengnan, Xi Shuhua
Epidemiological studies have indicated that ingestion of inorganic arsenic resulted in increased risks of bladder cancer and chronic hyperproliferation could play a direct role in the development of cancer. This study examined the effects of arsenite on JAK2/STAT3 pathway and expressions of proliferation and anti-apoptosis factors. The results showed that long term exposure to low doses arsenite enhanced human uroepithelial cells (SV-HUC-1 cells) proliferation and BrdU positive rate was significant increased...
April 26, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28443582/high-resolution-computed-tomography-and-pulmonary-function-findings-of-occupational-arsenic-exposure-in-workers
#16
Recai Ergün, Ender Evcik, Dilek Ergün, Begüm Ergan, Esin Özkan, Özge Gündüz
BACKGROUND: The number of studies where non-malignant pulmonary diseases are evaluated after occupational arsenic exposure are very few. AIMS: The aim of this study is to show the effects of occupational arsenic exposure on the lung by high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs). STUDY DESIGN: Retrospective cross-sectional study. METHODS: In this study 256 workers who were suspected respiratory occupational arsenic exposure are included, having average age 32...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28437293/increased-cancer-incidence-in-the-local-population-around-metal-contaminated-glassworks-sites
#17
Fredrik Nyqvist, Ingela Helmfrid, Anna Augustsson, Gun Wingren
OBJECTIVE: The aim of this study was to examine mortality causes and cancer incidence in a population cohort that have resided in close proximity to highly metal-contaminated sources, characterized by contamination of, in particular, arsenic (As), cadmium (Cd), and lead (Pb). METHODS: Data from Swedish registers were used to calculate standardized mortality and cancer incidence ratios. An attempt to relate cancer incidence to metal contamination levels was made...
May 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28433864/arsenic-metabolism-and-cancer-risk-a-meta-analysis
#18
REVIEW
Brenda Gamboa-Loira, Mariano E Cebrián, Francisco Franco-Marina, Lizbeth López-Carrillo
OBJECTIVE: To describe the studies that have reported association measures between risk of cancer and the percentage distribution of urinary inorganic arsenic (iAs) metabolites by anatomical site, in non-ecological epidemiological studies. METHODS: Studies were identified in the PubMed database in the period from 1990 to 2015. Inclusion criteria were: non-ecological epidemiological study, with histologically confirmed cancer cases, reporting the percentage distribution of inorganic arsenic (iAs), monomethylated (MMA) and dimethylated (DMA) metabolites, as well as association measures with confidence intervals (CI) between cancer and %iAs and/or %MMA and/or %DMA...
April 20, 2017: Environmental Research
https://www.readbyqxmd.com/read/28431356/heavy-metals-pollution-levels-and-children-health-risk-assessment-of-yerevan-kindergartens-soils
#19
Gevorg Tepanosyan, Nairuhi Maghakyan, Lilit Sahakyan, Armen Saghatelyan
Children, the most vulnerable urban population group, are exceptionally sensitive to polluted environments, particularly urban soils, which can lead to adverse health effects upon exposure. In this study, the total concentrations of Ag, As, Ba, Cd, Co, Cr, Cu, Fe, Hg, Mn, Mo, Ni, Pb, Ti, V, and Zn were determined in 111 topsoil samples collected from kindergartens in Yerevan. The objectives of this study were to evaluate heavy metal pollution levels of kindergarten's soils in Yerevan, compare with national legal and international requirements on heavy metal contents in kindergarten soil, and assess related child health risk...
August 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28427227/high-dose-ascorbate-and-arsenic-trioxide-selectively-kill-acute-myeloid-leukemia-and-acute-promyelocytic-leukemia-blasts-in-vitro
#20
Nélida I Noguera, Elvira Pelosi, Daniela F Angelini, Maria Liliana Piredda, Gisella Guerrera, Eleonora Piras, Luca Battistini, Lauretta Massai, Anna Berardi, Gianfranco Catalano, Laura Cicconi, Germana Castelli, Agnese D'Angiò, Luca Pasquini, Grazia Graziani, Giuseppe Fioritoni, Maria Teresa Voso, Domenico Mastrangelo, Ugo Testa, Francesco Lo-Coco
The use of high-dose ascorbate (ASC) for the treatment of human cancer has been attempted several decades ago and has been recently revived by several in vitro and in vivo studies in solid tumors. We tested the cytotoxic effects of ASC, alone or in combination with arsenic trioxide (ATO) in acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL). Leukemic cell lines and primary blasts from AML and APL patients were treated with graded concentrations of ASC, alone or in association with standard concentration (1 μM) of ATO...
May 16, 2017: Oncotarget
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