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https://www.readbyqxmd.com/read/29039521/antitumoral-effect-of-arsenic-compound-sodium-metaarsenite-kml001-on-multiple-myeloma-cells
#1
Seo Ju Kim, Eun Shil Kim, Sujong Kim, Jieun Uhm, Young Woong Won, Byeong Bae Park, Jung Hye Choi, Young Yiul Lee
KML001 (sodium metaarsenite;NaAs2O3) is known to have antitumor activity against a variety of cancers. In this study, we examined its effect on multiple myeloma (MM). KML001 reduced the growth of all MM cell lines examined with an IC50 of 5x10‑8 M. Exposure to KML001 (5x10‑8 M) decreased levels of cyclins A/B1/D1/E1, CDK2/4/6 in U266 cells and increased the p21 and p27 levels. Furthermore, p21 became bound to CDK2/4/6, resulting in a reduction of CDK2/4/6 kinase activity. The cleaved forms of Bcl-2, and caspases‑3, ‑8 and ‑9 were detected, and the anti-apoptotic molecule, Bax, also increased...
October 16, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29031057/arsenic-speciation-in-fish-and-shellfish-from-the-north-sea-southern-bight-and-a%C3%A3-u-port-area-brazil-and-health-risks-related-to-seafood-consumption
#2
Yue Gao, Paulo Baisch, Nicolai Mirlean, Flavio Manoel Rodrigues da Silva Júnior, Nik Van Larebeke, Willy Baeyens, Martine Leermakers
In North Sea and Port Açu (Brazil) coastal areas, high arsenic (As) concentrations were observed in water, soil and sediments. Therefore, the impact of this contamination on fish and shellfish species bought from local fishermen was studied. Total As was assessed with ICP-OES (Brazil) and ICP-MS (North Sea) after microwave digestion. Toxic As was assessed with liquid chromatography-ICP-MS (Brazil) and hydride generation-atomic fluorescence spectrometry (North Sea). All analytical methods comply with Quality Assurance/Quality Control procedures...
October 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29029427/environment-and-bladder-cancer-molecular-analysis-by-interaction-networks
#3
Andrea Polo, Anna Crispo, Pellegrino Cerino, Luca Falzone, Saverio Candido, Aldo Giudice, Giuseppina De Petro, Gennaro Ciliberto, Maurizio Montella, Alfredo Budillon, Susan Costantini
Bladder cancer (BC) is the 9th most common cancer worldwide, and the 6th most common cancer in men. Its development is linked to chronic inflammation, genetic susceptibility, smoking, occupational exposures and environmental pollutants. Aim of this work was to identify a sub-network of genes/proteins modulated by environmental or arsenic exposure in BC by computational network approaches. Our studies evidenced the presence of HUB nodes both in "BC and environment" and "BC and arsenicals" networks. These HUB nodes resulted to be correlated to circadian genes and targeted by some miRNAs already reported as involved in BC, thus suggesting how they play an important role in BC development due to environmental or arsenic exposure...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29028683/lung-cancer-associated-with-arsenic-ingestion-cell-type-specificity-and-dose-response
#4
Yau-Chang Kuo, Yu-Shing Lo, How-Ran Guo
BACKGROUND: Arsenic is a well-documented human carcinogen, and studies on urinary and skin cancers have shown that the carcinogenicity of ingested arsenic has cell-type specificity. To evaluate whether this is also true for lung cancers, we conducted a study on 243 townships in Taiwan. METHODS: The arsenic levels were assessed using measurement reports from a previous survey, and the incidence of lung cancer was assessed using the data gathered by the National Cancer Registry Program...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29016672/the-interaction-of-arsenic-and-n-butyl-n-4-hydroxybutyl-nitrosamine-on-urothelial-carcinogenesis-in-mice
#5
Yuan-Chang Dai, Shou-Chieh Wang, Mohammad Mezbahul Haque, Wei-Han Lin, Lei-Chen Lin, Ching-Hsein Chen, Yi-Wen Liu
The bladder is an important organ for the storage of excreted water and metabolites. If metabolites with carcinogenic characteristics are present in urine, the urothelial lining of the bladder could be damaged and genetically altered. In this study, we analyzed the interaction of arsenic and N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) on mouse bladder carcinogenesis. Our previous study found that arsenic affects BBN-altered urothelial enzymatic activity, protein expression, DNA oxidation and global DNA CpG methylation levels...
2017: PloS One
https://www.readbyqxmd.com/read/28988284/morphological-and-morphometrical-changes-on-adult-wistar-rat-testis-caused-by-chronic-sodium-arsenite-exposure
#6
Anderson Tadeu de Araújo Ramos, Maria Aparecida Silva Diamante, Celina de Almeida Lamas, Heidi Dolder, Fabrícia de Souza Predes
Arsenic is a contaminant that occurs naturally in the environment, and it is related to several diseases, such as cancer and severe metabolic diseases. Sodium arsenite effects on testes rats are not fully understood regarding morphology and stereology; thus, it becomes necessary to evaluate possible changes in these parameters under low concentrations and simulating occupational exposure. Therefore, the aim of this study was to analyze the morphometrical and stereological changes on rat testis treated with sodium arsenite...
October 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28984820/histopathology-of-cervical-cancer-and-arsenic-concentration-in-well-water-an-ecological-analysis
#7
Mohammad Golam Mostafa, Zarat Jahin Queen, Nicola Cherry
Arsenic in drinking water is causally linked with cancer of the skin, lung, and urinary bladder, but there is very little data on a possible role for arsenic in the etiology of cervical cancer, a disease in which human papilloma virus is held to be a necessary but not sufficient cause. All histopathology results from cervical specimens from the National Institute of Cancer Research and Hospital (NICRH), Dhaka (1997-2015), and the Anowara Medical Services (2003-2015), both serving the whole of Bangladesh, were classified by cell type...
October 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28980872/arsenic-trioxide-inhibits-cell-growth-and-motility-via-up-regulation-of-let-7a-in-breast-cancer-cells
#8
Ying Shi, Tong Cao, Hua Huang, Chaoqun Lian, Ying Yang, Zhiwei Wang, Jia Ma, Jun Xia
Arsenic trioxide (ATO) has been reported to exert its anti-cancer activities in human cancers. However, the molecular mechanism of ATO-triggered anti-tumor activity has not been fully elucidated. Recently, multiple studies demonstrated that ATO could regulate miRNAs in human cancers. Therefore, in this study, we investigated whether ATO regulated let-7a in breast cancer cells. We found that ATO upregulated let-7a level in breast cancer cells. We also found that up-regulation of let-7a inhibited cell growth and induced apoptosis and retarded cell migration and invasion...
October 5, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28974440/hijiki-and-sodium-arsenite-stimulate-growth-of-human-colorectal-adenocarcinoma-cells-through-erk1-2-activation
#9
Wanida Cholpraipimolrat, Tawit Suriyo, Nuchanart Rangkadilok, Sumontha Nookabkaew, Jutamaad Satayavivad
Hijiki seaweed (Hijikia fusiformes) contains high levels of inorganic arsenic, a known carcinogen. However, scientific reports on carcinogenic risks associated with the consumption of this seaweed are limited. This study investigated the effects of seaweed extracts contaminated with arsenic on two colorectal cancer cell lines. Two seaweed extracts, including Hijiki and red seaweed, induced H508 but not HT29 cell proliferation. Growth induction of H508 cells after treatments with Hijiki and sodium arsenite at concentrations equivalent to arsenic found in Hijiki was observed by both MTT and BrdU assays...
September 30, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28966729/arsenic-trioxide-induces-apoptosis-via-specific-signaling-pathways-in-ht-29-colon-cancer-cells
#10
Jacqueline J Stevens, Barbara Graham, Erika Dugo, Bezawit Berhaneselassie-Sumner, Kenneth Ndebele, Paul B Tchounwou
BACKGROUND: Arsenic trioxide (ATO) is highly effective in the treatment of patients with acute promyelocytic leukemia (APL). It is a chemotherapeutic agent that has been shown to induce apoptosis in several tumor cell lines. However, research into its effects on colon carcinoma cells is still very limited. We previously reported that ATO is cytotoxic and causes DNA damage in HT-29 human colorectal adenocarcinoma cells. In the present study, we further evaluated its effect on oxidative stress (OS), and examined its apoptotic mechanisms of action on HT-29 cells...
January 2017: Journal of Cancer Science & Therapy
https://www.readbyqxmd.com/read/28963906/abo-identical-and-washed-blood-transfusions-as-candidate-strategies-to-reduce-early-mortality-in-acute-promyelocytic-leukemia
#11
Tanmay Sahai, Kelly Henrichs, Majed Refaai, Joanna M Heal, Scott A Kirkley, Amy E Schmidt, Jason H Mendler, Debra Masel, Jane Liesveld, Christopher Aquina, Neil Blumberg
BACKGROUND: Despite dramatically improved long term outcomes seen with all-trans retinoic acid therapy, and now arsenic trioxide, in acute promyelocytic leukemia (APL), early mortality remains a substantial challenge. Recent data from a single center study and the Surveillance, Epidemiology and End Results (SEER) registry report 30day mortality rates of 26% (n=18 of 70) and 17% (n=238 of 1400), respectively. Early deaths are predominately due to hemorrhage. Patients with APL invariably have abnormal laboratory hemostasis tests...
September 23, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28959639/assessment-of-the-potential-health-risks-associated-with-the-aluminium-arsenic-cadmium-and-lead-content-in-selected-fruits-and-vegetables-grown-in-jamaica
#12
Johann M R Antoine, Leslie A Hoo Fung, Charles N Grant
Thirteen Jamaican-grown food crops - ackee (Blighia sapida), banana (Musa acuminate), cabbage (Brassica oleracea), carrot (Daucus carota), cassava (Manihot esculenta), coco (Xanthosoma sagittifolium), dasheen (Colocasia esculenta), Irish potato (Solanum tuberosum), pumpkin (Cucurbita pepo), sweet pepper (Capsicum annuum), sweet potato (Ipomoea batatas), tomato (Solanum lycopersicum) and turnip (Brassica rapa) - were analysed for aluminium, arsenic, cadmium and lead by atomic absorption spectrophotometry and instrumental neutron activation analysis...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28954465/particulate-matter-fine-particle-and-urologic-diseases
#13
REVIEW
Eun-A Kim
Particulate matter (PM) has been found to damage vital body organs, including the lungs and heart, through vascular damage and oxidative stress. Recently, renal function and chronic urologic diseases have also been found to be related to PM. To investigate this, we reviewed the characteristics of PM related to renal toxicity, including recent studies on the associations of urologic diseases with PM. PM can include constituents that cause renal toxicity, such as lead, cadmium, arsenic, and crystalline silica, which result in renal tubular or interstitial damage...
September 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28952002/south-asian-health-inflammation-infection-exposure-and-the-human-microbiome
#14
Jennifer Leng, Ponni Peruluswami, Sehrish Bari, Sunanda Gaur, Farshid Radparvar, Faruque Parvez, Yu Chen, Cristina Flores, Francesca Gany
This paper presents the results of the literature review conducted for the working group topic on inflammation, infection, exposure, and the human microbiome. Infection and chronic inflammation can elevate risk for cardiovascular disease and cancer. Environmental exposures common among South Asian (SA) subgroups, such as arsenic exposure among Bangladeshis and particulate matter air pollution among taxi drivers, also pose risks. This review explores the effects of exposure to arsenic and particulate matter, as well as other infections common among SAs, including human papillomavirus (HPV) and hepatitis B/C infection...
September 27, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28949802/health-risk-assessment-of-arsenic-from-blended-water-in-distribution-systems
#15
Hui Zhang, Xue Zhou, Kai Wang, Wen D Wang
In a water distribution system with different sources, water blending occurs, causing specific variations of the arsenic level. This study was undertaken to investigate the concentration and cancer risk of arsenic in blended water in Xi'an city. A total of 672 tap water samples were collected from eight sampling points in the blending zones for arsenic determination. The risk was evaluated through oral ingestion and dermal absorption, separately for males and females, as well as with respect to seasons and blending zones...
September 26, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28939896/mir-155-mediates-arsenic-trioxide-resistance-by-activating-nrf2-and-suppressing-apoptosis-in-lung-cancer-cells
#16
Shiyan Gu, Yanhao Lai, Hongyu Chen, Yuan Liu, Zunzhen Zhang
Arsenic trioxide (ATO) resistance is a challenging problem in chemotherapy. However, the underlying mechanisms remain to be elucidated. In this study, we identified a high level of expression of miR-155 in a human lung adenocarcinoma A549R cell line that is highly resistant to ATO. We showed that the high level of miR-155 was associated with increased levels of cell survival, colony formation, cell migration and decreased cellular apoptosis, and this was mediated by high levels of Nrf2, NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1) and a high ratio of Bcl-2/Bax...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28934722/rice-consumption-and-squamous-cell-carcinoma-of-the-skin-in-a-united-states-population
#17
Anala Gossai, M Scot Zens, Tracy Punshon, Brian P Jackson, Ann E Perry, Margaret R Karagas
BACKGROUND: Rice contains arsenic, a known skin carcinogen. Rice intake has been associated with arsenic-related skin lesions in South Asia, but its association with skin cancers is as yet unknown. OBJECTIVES: We aimed to investigate whether rice intake contributes to urinary arsenic concentration and risk of squamous cell carcinoma (SCC) of the skin in a U.S. population. METHODS: Rice consumption was assessed using a food frequency questionnaire administered as part of a population-based case-control study of 487 SCC cases and 462 age- and gender-matched controls...
September 7, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28930584/metal-and-metalloid-containing-drugs-for-the-treatment-of-trypanosomatid-diseases
#18
Gianni Colotti, Annarita Fiorillo, Andrea Ilari
The trypanosomatid-induced diseases are considered as neglected, because the countries where they kill people are not important markets for western big pharmaceutical companies. However, recently some effort has been made to translate the use of already known drugs to neglected infectious disease. Although many metals are essential to life, many disorders affecting metal homeostasis and bioavailability are responsible for several human diseases. Metals can be toxic even at very low concentrations and semimetals are classified as toxic and dangerous for the environment...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929460/trace-metal-levels-in-rainbow-trout-oncorhynchus-mykiss-cultured-in-net-cages-in-a-reservoir-and-evaluation-of-human-health-risks-from-consumption
#19
Memet Varol, Gülderen Kurt Kaya, Sumru Anık Alp, Muhammet Raşit Sünbül
Although fish consumption has positive health effects, metals accumulated in fish can cause human health risks. In this study, the levels of ten metals in rainbow trout (Oncorhynchus mykiss) farmed in the Keban Dam Reservoir, which has the biggest rainbow trout production capacity in Turkey, were determined and compared with the maximum permissible levels (MPLs). Also, human health risks associated with rainbow trout consumption were assessed. The metal concentrations in rainbow trout were found below the MPLs...
September 19, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28928847/anti-angiogenic-effect-of-arsenic-trioxide-in-lung-cancer-via-inhibition-of-endothelial-cell-migration-proliferation-and-tube-formation
#20
Meng-Hang Yang, Ke-Jie Chang, Jin-Cheng Zheng, Hai Huang, Guang-Yuan Sun, Xue-Wei Zhao, Bing Li, Qing-Yu Xiu
Arsenic trioxide (As2O3) exhibits a remarkable effect on leukemia treatment; however, its effect on solid tumors remains poorly explored. The present study demonstrated the inhibitory effect of As2O3 on lung cancer and explored its possible mechanism. It was observed that As2O3 significantly inhibited the growth of lung cancer xenografts and tumor angiogenesis in vivo. The inhibitory effect of As2O3 on cell proliferation in vitro was more remarkable in vascular endothelial cells than in lung cancer cells. It was also observed that As2O3 inhibited the migration of vascular endothelial cells and disrupted vascular tube formation on Matrigel assays...
September 2017: Oncology Letters
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