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Oral squamous cell carcinoma

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https://www.readbyqxmd.com/read/29034278/cytotoxic-effect-of-thiabendazole-on-hn5-head-and-neck-squamous-cell-carcinoma-cell-line
#1
Amir Jalal Abassi, Abdolreza Mohamadnia, Seyed Alireza Parhiz, Nahid Azizi Moghadam, Naghmeh Bahrami
STATEMENT OF THE PROBLEM: Evidence shows thiabendazole has the potential to inhibit angiogenesis in melanoma and fibrosarcoma; however, its effect on oral squamous cell carcinoma has not been previously studied. PURPOSE: This study sought to assess the cytotoxic effects of thiabendazole on HN5 head and neck squamous carcinoma cell line. MATERIALS AND METHOD: HN5 cell lines were exposed to different concentrations of thiabendazole (prepared from 99% pure powder) for 24, 48 and 72 hours...
September 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29034276/evaluation-of-the-ki-67-and-mcm3-expression-in-cytologic-smear-of-oral-squamous-cell-carcinoma
#2
Fahimeh Rezazadeh, Rahele Ebrahimi, Azadeh Andisheh-Tadbir, Mohammad Javad Ashraf, Bijan Khademi
STATEMENT OF THE PROBLEM: Squamous cell carcinoma (SCC) is the most frequent oral cancer whose 5-year survival rate is 80% for early-detected lesions and nearly 30-50% for advanced lesions. Early detection of oral cancers and precancerous lesions can improve the patient's survival and decrease the morbidity. PURPOSE: This study aimed to evaluate and compare the Ki-67 and MCM3 expression in cytologic smear of oral SCC (OSCC). MATERIALS AND METHOD: We examined 48 oral brush biopsies including 28 OSCC and 20 healthy non-smoking samples...
September 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29033209/a-worldwide-comparison-of-the-management-of-t1-and-t2-anterior-floor-of-the-mouth-and-tongue-squamous-cell-carcinoma-extent-of-surgical-resection-and-reconstructive-measures
#3
Katinka Kansy, Andreas Albert Mueller, Thomas Mücke, Friederike Koersgen, Klaus Dietrich Wolff, Hans-Florian Zeilhofer, Frank Hölzle, Winnie Pradel, Matthias Schneider, Andreas Kolk, Ralf Smeets, Julio Acero, Piet Haers, G E Ghali, Jürgen Hoffmann
INTRODUCTION: Microvascular surgery following tumor resection has become an important field of oral maxillofacial surgery (OMFS). Following the results on general aspects of current reconstructive practice in German-speaking countries, Europe and worldwide, this paper presents specific concepts for the management of resection and reconstruction of T1/T2 squamous cell carcinoma (SCC) of the anterior floor of the mouth and tongue. METHODS: The DOESAK questionnaire was distributed in three different phases to a growing number of maxillofacial units worldwide...
September 21, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29033003/clinicopathological-parameters-affecting-nodal-yields-in-patients-with-oral-squamous-cell-carcinoma-receiving-selective-neck-dissection
#4
Ali-Farid Safi, Martin Kauke, Andrea Grandoch, Hans-Joachim Nickenig, Uta Drebber, Joachim Zöller, Matthias Kreppel
INTRODUCTION: Nodal yield has been demonstrated as a very promising marker for the prognostic outcome of patients with oral squamous cell carcinoma. However, studies on the importance of clinicopathological factors affecting the number of resected lymph nodes are rare, especially for patients without pathologically proven cervical lymph nodes. MATERIAL AND METHODS: Retrospective chart review of 264 patients with treatment naive oral squamous cell carcinoma and histopathologically proven negative cervical lymph node status, who received selective neck dissection of levels I-III/IV...
September 10, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29031202/targeting-of-cell-cycle-and-let-7a-stat3-pathway-by-niclosamide-inhibits-proliferation-migration-and-invasion-in-oral-squamous-cell-carcinoma-cells
#5
Xiaoxu Li, Ruiyu Ding, Zewen Han, Zeyun Ma, Yixiang Wang
The low median survival rate of oral squamous cell carcinoma (OSCC) is associated with chemotherapeutic resistance. Niclosamide is an oral anti-helminthic drug, its anti-cancer effect has been reported in recent years. However, the effect of niclosamide on OSCC remains largely unknown. In this study, we, for the first time, investigated the underlying mechanisms from cell cycle arrest and let-7a/STAT3 axis through CCK-8, cell cycle, apoptosis, wound healing, Transwell invasion, generation of stable cell line, real-time PCR, and western blot assays using two OSCC cell lines WSU-HN6 and Tca83...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29030590/cytotoxicity-of-thymoquinone-alone-or-in-combination-with-cisplatin-cddp-against-oral-squamous-cell-carcinoma-in-vitro
#6
Omar M Alaufi, Abdulwahab Noorwali, Fatheya Zahran, Ahmed M Al-Abd, Safia Al-Attas
Cisplatin (CDDP) is potent anticancer agent used for several tumor types. Thymoquinone (TQ) is naturally occurring compound drawing great attention as anticancer and chemomodulator for chemotherapies. Herein, we studied the potential cytotoxicity of thymoquinone, CDDP and their combination against human oral squamous cell carcinoma cell in contrast to normal oral epithelial cells. CDDP similarly killed both head and neck squamous cell carcinoma cells (UMSCC-14C) and normal oral epithelial cells (OEC). TQ alone exerted considerable cytotoxicity against UMSCC-14C cells; while it induced weaker killing effect against normal oral epithelial cells (OEC)...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29030021/hypoxic-volume-evaluated-by-18-f-fluoromisonidazole-positron-emission-tomography-fmiso-pet-may-be-a-prognostic-factor-in-patients-with-oral-squamous-cell-carcinoma-preliminary-analyses
#7
J Sato, Y Kitagawa, S Watanabe, T Asaka, N Ohga, K Hirata, T Shiga, A Satoh, N Tamaki
Tumour hypoxia can be detected by (18)F-fluoromisonidazole positron emission tomography (FMISO-PET). Few studies have assessed the relationships of new PET parameters, including hypoxic volume (HV), metabolic tumour volume (MTV), and total lesion glycolysis (TLG), with 5-year survival of patients treated surgically for oral squamous cell carcinoma (OSCC). This study evaluated the relationships between these PET parameters and 5-year survival in OSCC patients. Twenty-three patients (age 42-84 years; 15 male, eight female) with OSCC underwent FMISO- and (18)F-fluoro-2-deoxyglucose (FDG)-PET computed tomography before surgery...
October 10, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29029509/establishment-of-oral-squamous-cell-carcinoma-cell-line-and-magnetic-bead-based-isolation-and-characterization-of-its-cd90-cd44-subpopulations
#8
Marketa Svobodova, Martina Raudenska, Jaromir Gumulec, Jan Balvan, Michaela Fojtu, Monika Kratochvilova, Hana Polanska, Zuzana Horakova, Rom Kostrica, Petr Babula, Zbynek Heger, Michal Masarik
In this study, we describe the establishment of the human papillomavirus 18-positive, stage II, grade 1, T2N0M0 head and neck tumor primary cell line derived from oral squamous cell carcinoma of a non-smoking patient by using two different protocols. Furthermore, a preparation of subpopulations derived from this primary cell line according to the cluster of differentiation molecules CD44/CD90 status using magnetic bead-based separation and their characterization was performed. Impedance-based real-time cell analysis, enzyme-linked immunsorbant assay (ELISA), wound-healing assay, flow-cytometry, gene expression analysis, and MTT assay were used to characterize these four subpopulations (CD44(+)/CD90(-), CD44(-)/CD90(-), CD44(+)/CD90(+), CD44(-)/CD90(-))...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029502/clinicopathologic-implications-of-the-mir-197-pd-l1-axis-in-oral-squamous-cell-carcinoma
#9
Hyein Ahn, Jeong Mi Yang, Hyojin Kim, Jin-Haeng Chung, Soon-Hyun Ahn, Woo-Jin Jeong, Jin Ho Paik
Immune escape of a tumor from tumor-infiltrating lymphocytes (TILs) is induced by PD-L1, which is suppressed by miR-197. We investigated the clinicopathologic implications of the miR-197/PD-L1 axis and its effects on TILs and the clinicopathologic features of oral squamous cell carcinoma (OSCC). We used RT-PCR and immunohistochemistry in 68 OSCC patients to analyze the correlations between tumoral expression of miR-197 and PD-L1 and the degree of tumoral invasion by TILs (CD3+, CD4+, CD8+, PD-1+, FoxP3+, and CD20+ lymphocytes)...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029021/aetiological-heterogeneity-of-head-and-neck-squamous-cell-carcinomas-the-role-of-human-papillomavirus-infections-smoking-and-alcohol
#10
Nada J Farsi, Marie-Claude Rousseau, Nicolas Schlecht, Geneviève Castonguay, Paul Allison, Phuc Félix Nguyen-Tan, Denis Soulieres, Francois Coutlée, Michael Hier, Sreenath Madathil, Eduardo L Franco, Belinda Nicolau
Tobacco and alcohol consumption are the main risk factors for head and neck squamous cell carcinoma (HNSCC). In addition, human papillomavirus (HPV) infection plays a causal role in oropharyngeal cancer (OPC), a subset of HNSCC. We assessed the independent effects of tobacco, alcohol, and HPV infection on OPC risk in the Head and Neck Cancer(HeNCe) Life study, a hospital-based case-control study of HNSCC with frequency-matched controls by age and sex from four Montreal hospitals. Interviewers collected information on socio-demographic and behavioural factors...
September 28, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29026519/squamous-cell-carcinoma-arising-in-familial-gingival-fibromatosis-a-rare-case-report
#11
Dilasma Ghartimagar, Ujjwal Koirala, Arnab Ghosh, Manish Kiran Shrestha, Sushma Thapa, Raghavan Narasimhan, O P Talwar
Familial gingival fibromatosis is a rare hereditary condition due to chromosomal abnormality which can occur as an isolated disease or as part of a syndrome and has an incidence of 1:350 000. This condition leads to esthetic, functional, psychological and masticatory disturbance of the oral cavity. Here, we present a case of 21-year-old female with severe enlargement of gums in maxilla and mandible. Deciduous teeth were erupted at normal age but the permanent teeth in the oral cavity were not erupted. Her grandmother, father and younger sister were also affected with the same condition...
October 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29025723/setting-the-stage-for-2018-how-the-changes-in-the-american-joint-committee-on-cancer-union-for-international-cancer-control-cancer-staging-manual-eighth-edition-impact-radiologists
#12
C M Glastonbury, S K Mukherji, B O'Sullivan, W M Lydiatt
The updated eighth edition of the Cancer Staging Manual of the American Joint Committee on Cancer will be implemented in January 2018. There are multiple changes to the head and neck section of the manual, which will be relevant to radiologists participating in multidisciplinary head and neck tumor boards and reading pretreatment head and neck cancer scans. Human papillomavirus-related/p16(+) oropharyngeal squamous cell carcinoma will now be staged separately; this change reflects the markedly better prognosis of these tumors compared with non-human papillomavirus/p16(-) oropharyngeal squamous cell carcinoma...
October 12, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29024498/feasibility-and-efficiency-of-concurrent-chemoradiotherapy-with-capecitabine-and-cisplatin-versus-radiotherapy-alone-for-elderly-patients-with-locally-advanced-esophageal-squamous-cell-carcinoma-experience-of-two-centers
#13
Fangjie Chen, Hui Luo, Ligang Xing, Ning Liang, Jian Xie, Jiandong Zhang
BACKGROUND: The purpose of this retrospective study was to evaluate the feasibility and efficacy of definitive concurrent chemoradiotherapy (CCRT) with capecitabine and cisplatin for elderly patients with locally advanced esophageal squamous cell carcinoma. METHODS: A total of 90 patients were included from two different centers. Forty-nine patients were treated with CCRT consisting of capecitabine (850 mg/m(2) , oral, twice a day for 1-14 days) and cisplatin (20 mg/m(2) ) weekly during radiotherapy (RT)...
October 12, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/29024035/the-role-of-human-papillomavirus-in-p16-positive-oral-cancers
#14
Simone Belobrov, Alyssa M Cornall, Richard J Young, Kendrick Koo, Christopher Angel, David Wiesenfeld, Danny Rischin, Suzanne M Garland, Michael McCullough
BACKGROUND: The aim of the present study was to identify the presence and frequency of human papillomavirus (HPV) nucleic acid in p16 positive oral squamous cell carcinomas (OSCC), to assess if the virus were transcriptionally active, and to assess the utility of p16 overexpression as a surrogate marker for HPV in OSCC. METHODS: Forty-six OSCC patients treated between 2007 and 2011 with available formalin-fixed paraffin embedded (FFPE) specimens were included. Twenty-three patients were positive for p16 by immunohistochemistry (IHC) and these were matched with 23 patients with p16 negative tumours...
October 11, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29023924/decreased-peritumoral-cd1a-cells-predicts-worse-prognosis-in-oral-squamous-cell-carcinoma
#15
Juscelino Freitas Jardim, Rogério Gondak, Marisol Miranda Galvis, Clovis Antonio Lopes Pinto, Luiz Paulo Kowalski
BACKGROUND: Dendritic cells (DCs) are known to play a central role in the regulation of both innate and adaptive immunologic responses, including antitumor immunity. This study aimed to evaluate the prognostic impact of intra and peritumoral dendritic cells in oral squamous cell carcinoma (OSCC) affecting tongue and floor of the mouth. PATIENTS AND METHODS: Immunohistochemical reactions for CD1a and CD83 were performed in 53 patients with OSCC in tongue and floor of the mouth...
October 11, 2017: Histopathology
https://www.readbyqxmd.com/read/29022861/molecular-characterization-prevalence-and-clinical-relevance-of-phodopus-sungorus-papillomavirus-type-1-psupv1-naturally-infecting-siberian-hamsters-phodopus-sungorus
#16
Boštjan J Kocjan, Lea Hošnjak, Joško Račnik, Marko Zadravec, Nejc Bakovnik, Blaž Cigler, Monique Ummelen, Anton H N Hopman, Nina Gale, Tanja Švara, Mitja Gombač, Mario Poljak
Phodopus sungorus papillomavirus type 1 (PsuPV1), naturally infecting Siberian hamsters (Phodopus sungorus) and clustering in the genus Pipapillomavirus (Pi-PV), is only the second PV type isolated from the subfamily of hamsters. In silico analysis of three independent complete viral genomes obtained from cervical adenocarcinoma, oral squamous cell carcinoma and normal oral mucosa revealed that PsuPV1 encodes characteristic viral proteins (E1, E2, E4, E6, E7, L1 and L2) with conserved functional domains and a highly conserved non-coding region...
October 12, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29022097/prevalence-of-fibroblast-growth-factor-receptor-1-fgfr1-amplification-in-squamous-cell-carcinomas-of-the-head-and-neck
#17
Till Sebastian Clauditz, Arne Böttcher, Henning Hanken, Kerstin Borgmann, Guido Sauter, Waldemar Wilczak, Tobias Grob, Adrian Münscher
BACKGROUND: FGFR1 is a receptor tyrosine kinases involved in tumor growth signaling, survival, and differentiation in many solid cancer types. There is growing evidence that FGFR1 amplification might predict therapy response to FGFR1 inhibitors in squamous cell lung cancers. To estimate the potential applicability of anti FGFR1 therapies in squamous cell carcinomas of the head and neck, we studied patterns of FGFR1 amplification using fluorescence in situ hybridization (FISH). MATERIALS AND METHODS: A tissue microarray was constructed from 453 primary treatment-naive squamous cell carcinomas of the head and neck regions with histopathological and clinical follow-up data [including oral cavity (n = 222), oropharynx (n = 126), and larynx (n = 105)]...
October 11, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29021136/distinct-angiogenic-changes-during-carcinogenesis-defined-by-novel-label-free-dark-field-imaging-in-a-hamster-cheek-pouch-model
#18
Fangyao Hu, Hannah Martin, Amy Frees Martinez, Jeffrey Everitt, Alaattin Erkanli, Walter T Lee, Mark W Dewhirst, Nirmala Ramanujam
There remain gaps in knowledge concerning how vascular morphology evolves during carcinogenesis. In this study, we imaged neovascularization by label-free dark field microscopy of a DMBA-induced hamster cheek pouch model of oral squamous cell carcinoma (SCC). Wavelength-dependent imaging revealed distinct vascular features at different imaging depths and vessel sizes. Vascular tortuosity increased significantly in high-risk lesions, while diameter decreased significantly in hyperplastic and SCC lesions. Large vessels preserved the same trends seen in the original images, whereas small vessels displayed different trends, with length and diameter increasing during carcinogenesis...
October 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/29018057/pd-1-blockade-prevents-the-development-and-progression-of-carcinogen-induced-oral-premalignant-lesions
#19
Jin Wang, Tong-Xin Xie, Bingbing Wang, William N William, John Heymach, Adel K El-Naggar, Jeffrey N Myers, Carlos Caulin
Oral squamous cell carcinoma (OSCC) is preceded by progressive oral premalignant lesions (OPLs). Therefore, therapeutic strategies that prevent malignant progression of OPLs are expected to reduce the incidence of OSCC development. Immune checkpoint inhibitors that target the interaction of programmed death receptor 1 (PD-1) on T cells with the PD-1 ligand PD-L1 on cancer cells have been shown to extend the survival of patients with advanced OSCC. Here, we used the 4-Nitroquinoline-1-oxide (4-NQO) mouse model of oral carcinogenesis to test the hypothesis that PD-1 blockade may control the progression of OPLs...
October 10, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28988428/risk-factors-for-salvage-surgery-failure-in-oral-cavity-squamous-cell-carcinoma
#20
Danielli Matsuura, Tiago Dias Valim, Marco Aurélio Vamondes Kulcsar, Fábio Roberto Pinto, Lenine Garcia Brandão, Claudio Roberto Cernea, Leandro Luongo Matos
OBJECTIVES/HYPOTHESIS: Locoregional recurrences of oral cavity squamous cell carcinoma (SCC) may be diagnosed during follow-up of surgically treated patients. Nevertheless, few studies have investigated factors that impact salvage surgery failure and the mortality rates of these patients. The objectives were to identify predictive factors of salvage surgery failure and mortality in patients who undergo surgical treatment for recurrent oral cavity SCC and to compare the overall survival rates of these patients with those of patients who undergo only one surgical treatment...
October 8, 2017: Laryngoscope
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