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Oral squamous cell carcinoma

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https://www.readbyqxmd.com/read/29691556/-expression-and-correlation-of-hpv16e6-and-tumor-suppressor-gene-p53-in-oral-squamous-cell-carcinoma
#1
Huai-Qi Li, He-Ming Wu, Xu Ding, Jin-Hai Ye, Yu-Nong Wu
PURPOSE: To exploring the expression of PV16E6 gene and p53 gene in patients with oral carcinoma and the correlation between pathological grade and clinical stage of oral cancer and expression of HPV16E6 gene and p53 gene. METHODS: One hundred and seventy-three cases of oral cancer, 98 cases of oral precancerous lesions and 79 cases of peri-cancerous normal tissue were selected. The expression of HPV16E6 and p53 was detected by immunohistochemistry. The data were analyzed using SPSS 21...
December 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29690696/-expression-and-potential-clinical-significance-of-cytidine-triphosphate-phosphocholine-cytidylyltransferase-%C3%AE-in-oral-squamous-cell-carcinoma
#2
F C Lu, X Y Xie, X M Yin, Y J Gao
Objective: To examine the expression and potential clinical significance of CCT (cytidine triphosphate: phosphocholine cytidylyltransferase)-α in oral squamous cell carcinoma (OSCC). Methods: Fifty-eight OSCC and paired adjacent non-malignant epithelia samples (between May 2016 and July 2016) were obtained from dental center, Second Xiangya Hospital, Central South University. CCT-α expression was examined by immunohistochemistry. The relationship between CCT-α and clinicopathological features of OSCC patients was analyzed...
April 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29690695/-comparative-analysis-of-methylation-profiles-in-tissues-of-oral-leukoplakia-and-oral-squamous-cell-carcinoma
#3
J Fu, Y Su, Y Liu, X Y Zhang
Objective: To compare the methylation profiles in tissues of oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC) with healthy tissues of oral mucosa, in order to identify the role of DNA methylation played in tumorigenesis. Methods: DNA samples extracted from tissues of 4 healthy oral mucosa, 4 OSCC and 4 OLK collected from patients of the Department of Oral Medicine, Capital Medical University School of Stomatology were examined and compared using Methylation 450 Bead Chip. The genes associated with differentially methylated CpG sites were selected for gene ontology (GO) analysis and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment...
April 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29687243/endorsing-cellular-competitiveness-in-aberrant-epithelium-of-oral-submucous-fibrosis-progression-neighbourhood-analysis-of-immunohistochemical-attributes
#4
Anji Anura, Anees Kazi, Mousumi Pal, Ranjan Rashmi Paul, Sanghamitra Sengupta, Jyotirmoy Chatterjee
Epithelial abnormality during the transformation of oral submucous fibrosis (OSF) into oral squamous cell carcinoma has been well studied and documented. However, the differential contribution of atrophy and hyperplasia for malignant potentiality of OSF is yet to be resolved. Existing diagnostic conjectures lack precise diagnostic attributes which may be effectively resolved by substantiation of specific molecular pathology signatures. Present study elucidates existence of cellular competitiveness in OSF conditions using computer-assisted neighbourhood analysis in quantitative immunohistochemistry (IHC) framework...
April 23, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29686919/grinspan-s-syndrome-a-rare-case-with-malignant-transformation
#5
Numan Kökten, Lokman Uzun, Ayşe Serap Karadağ, Tülay Zenginkinet, M Tayyar Kalcıoğlu
Aim: Oral lichen planus (OLP) is one of the common chronic inflammatory, noninfectious, and precancerous oral mucosal diseases that affect the stratified squamous epithelium in adults. Grinspan et al. reported an association of OLP with diabetes mellitus and vascular hypertension and called that Grinspan's syndrome in 1966. We aim to present a case of Grinspan's syndrome with malignant transformation. Case Presentation: A 60-year-old man who presented with a ten-year history of OLP diagnosed clinically and histologically was referred to our otolaryngology department with a painless swallowing in the left buccal mucosa for 3 months...
2018: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29686705/intraoral-potentially-malignant-disorders-in-a-brazilian-oral-pathology-service-epidemiological-clinical-and-histopathological-findings
#6
Fernanda Weber Mello, Gilberto Melo, Maria Inês Meurer, Elena Riet Correa Rivero
The aim of this study was to investigate the characteristics of individuals with intraoral potentially malignant disorders (IOPMD) in an oral pathology service in Brazil. Cases were screened based on clinical diagnosis of leukoplakia (LKP), erythroleukoplakia (ELKP), and erythroplakia (EP). Clinical data and information regarding associated factors were gathered from biopsy reports. Histological diagnoses were collected from histopathological records. Among 208 IOPMD cases, 84.13% involved LKP; 11.1%, ELKP; and 4...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29685024/oral-lichen-planus
#7
L Giannetti, A M Dello Diago, E Spinas
Oral Lichen planus (OLP) is the most frequent mucosal localization of Lichen planus, affecting about 1-2% of the population. It is associated with skin lesions in 60-70% of cases, while occurring as the only manifestations in 15-25% of patients. Six clinical forms of OLP are identified: reticular (the most common), plaque, papular, atrophic, vesicles/bullous and erosive. The evolution is chronic, especially in the erosive form. A 1% incidence of squamous-cell carcinoma has been reported, thus considering OLP as a potential premalignant condition...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29682222/immunoexpression-of-cytokeratin-19-in-the-oral-lichen-planus-and-related-oral-squamous-cell-carcinoma
#8
Gian Paolo Bombeccari, Aldo Bruno Giannì, Francesco Spadari
Aims: Cytokeratin 19 (CK-19) is an epithelium-specific intermediate filament protein that has been investigated in oral lichen planus (OLP) lesions but has not been compared with the expression of CK-19 in the OLP-related oral squamous cell carcinoma (OSCC). The aim of the present study has been to objectively compare the immunohistochemical expression of the CK-19 in OLP lesions and subsequent OSCC lesions that developed over time, to evaluate the change of the staining pattern among OLP and the grades of differentiation in OSCC...
September 2017: Annali di Stomatologia
https://www.readbyqxmd.com/read/29682214/head-and-neck-squamous-cell-carcinoma-and-its-correlation-with-human-papillomavirus-in-people-living-with-hiv-a-systematic-review
#9
REVIEW
Manuela Ceccarelli, Emmanuele Venanzi Rullo, Alessio Facciolà, Giordano Madeddu, Bruno Cacopardo, Rosaria Taibi, Francesco D'Aleo, Marilia Rita Pinzone, Isa Picerno, Michele di Rosa, Giuseppa Visalli, Fabrizio Condorelli, Giuseppe Nunnari, Giovanni Francesco Pellicanò
Over the last 20 years we assisted to an increase in the mean age of People Living with HIV and their comorbidities. Especially, there was an increase in Human Papillomavirus-related head and neck squamous cell carcinomas. Despite their increasing incidence in HIV-positive people, mechanisms that lead to their development and progression are only partially understood. The aim of this review is to identify key data and factors about HPV-related head and neck squamous cell carcinoma in HIV-seropositive patients...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29682099/markers-of-oral-lichen-planus-malignant-transformation
#10
REVIEW
Mircea Tampa, Constantin Caruntu, Madalina Mitran, Cristina Mitran, Isabela Sarbu, Laura-Cristina Rusu, Clara Matei, Carolina Constantin, Monica Neagu, Simona-Roxana Georgescu
Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with significant impact on patients' quality of life. Malignant transformation into oral squamous cell carcinoma (OSCC) is considered as one of the most serious complications of the disease; nevertheless, controversy still persists. Various factors seem to be involved in the progression of malignant transformation; however, the mechanism of this process is not fully understood yet. Molecular alterations detected in OLP samples might represent useful biomarkers for predicting and monitoring the malignant progression...
2018: Disease Markers
https://www.readbyqxmd.com/read/29682090/the-neuropeptide-genes-sst-tac1-hcrt-npy-and-gal-are-powerful-epigenetic-biomarkers-in-head-and-neck-cancer-a-site-specific-analysis
#11
Kiyoshi Misawa, Masato Mima, Atsushi Imai, Daiki Mochizuki, Yuki Misawa, Shiori Endo, Ryuji Ishikawa, Takeharu Kanazawa, Hiroyuki Mineta
Background: Staging and pathological grading systems are convenient but imperfect predictors of recurrence in head and neck squamous cell carcinoma (HNSCC). Identifying biomarkers for HNSCC that will progress and cause death is a critical research area, particularly if the biomarker can be linked to selection of patients. Therefore, to identify potential alternative prognostic markers, we investigated the methylation status of five neuropeptide gene promoters. The promoter methylation status was determined by quantitative methylation-specific PCR in 230 cases of HNSCC; 58 hypopharynx, 45 larynx, 56 oropharynx, and 71 oral cavity tumor samples were studied...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29681158/proteomic-analysis-of-cancer-associated-fibroblasts-reveal-a-paracrine-role-for-mfap5-in-human-oral-tongue-squamous-cell-carcinoma
#12
Simona Principe, Salvador Mejia-Guerrero, Vladimir Ignatchenko, Ankit Sinha, Alex Ignatchenko, Wei Shi, Keira Pereira, Susie Su, Shao Hui Huang, Brian O'Sullivan, Wei Xu, David Goldstein, Ilan Weinreb, Laurie Ailles, Fei-Fei Liu, Thomas Kislinger
Bidirectional communication between cells and their microenvironment is crucial for both normal tissue homeostasis and tumor growth. During the development of oral tongue squamous cell carcinoma (OTSCC), cancer-associated fibroblasts (CAFs) create a supporting niche by maintaining a bidirectional crosstalk with cancer cells, mediated by classically secreted factors and various nanometer-sized vesicles, termed as extracellular vesicles (EVs). To better understand the role of CAFs within the tumor stroma and elucidate the mechanism by which secreted proteins contribute to OTSCC progression, we isolated and characterized patient-derived CAFs from resected tumors with matched adjacent tissue fibroblasts (AFs)...
April 22, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29679798/liposomal-formulations-of-magnesium-sulfanyl-tribenzoporphyrazines-for-the-photodynamic-therapy-of-cancer
#13
Jaroslaw Piskorz, Dariusz T Mlynarczyk, Wojciech Szczolko, Krystyna Konopka, Nejat Düzgüneş, Jadwiga Mielcarek
Photodynamic therapy of cancer comprises the activation of photosensitizer molecules delivered to cancer cells, to generate reactive oxygen species that mediate cytotoxicity. In this study, previously synthesized dendritic magnesium tribenzoporphyrazines were incorporated into four types of liposomes containing either 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) or 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) as the zwitterionic lipids. The addition of either l-α-phosphatidyl-dl-glycerol (PG) or 1,2-dioleoyl-3-trimethylammoniumpropane (DOTAP) imparted a negative or positive charge, respectively...
April 9, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29679592/multiple-coagulation-factor-deficiency-protein-2-as-a-crucial-component-in-metastasis-of-human-oral-cancer
#14
Megumi Fukamachi, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Kazuaki Fushimi, Hiroki Kasama, Manabu Iyoda, Yasuyuki Minakawa, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa
Multiple coagulation factor deficiency protein 2 (MCFD2), a binding partner of lectin mannose binding 1 (LMAN1), causes combined deficiencies of coagulation factors V and VIII. MCFD2 function in inherited hematologic disorders is well elucidated; however, little is known about its role in human tumorigenesis. The aim of the current study was to investigate the states of MCFD2 in oral squamous cell carcinoma (OSCC). The expression of MCFD2 was up-regulated significantly in all cell lines examined. Evaluation of the cellular functions associated with tumoral metastasis showed that MCFD2 knockdown (shMCFD2) cells exhibited significantly lower cellular invasiveness and migration and higher cellular adhesion compared with shControl cells...
April 18, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29675970/does-hypoxia-inducible-factor-1-%C3%AE-hif-1-%C3%AE-c1772t-polymorphism-predict-short-term-prognosis-in-patients-with-oral-squamous-cell-carcinoma-oscc
#15
Jitender Prasad, Binita Goswami, Srinivas H Gowda, Nikhil Gupta, Shilpa Kumar, Kiran Agarwal, Pravesh Mehra, Bindiya K Pahuja, Anju Chauhan
BACKGROUND: Oral squamous cell carcinoma (OSCC) is a cancer of the oral cavity that is a major health problem in India. There is an urgent need to identify biomarkers that have prognostic significance. We studied HIF1 α levels as well as single nucleotide polymorphism of HIF1α gene in cancer and healthy controls. METHODS: Fifty newly diagnosed OSCC patients and 50 age and sex matched healthy control were included in the study. Serum concentrations of HIF1 α were measured by sandwich ELISA; whereas HIF1 α gene polymorphism study was done using restriction enzyme digestion by HpH I...
April 20, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29675646/validation-of-the-8th-edition-of-the-ajcc-uicc-tnm-staging-system-for-tongue-squamous-cell-carcinoma
#16
Satoshi Kano, Tomohiro Sakashita, Nayuta Tsushima, Takatsugu Mizumachi, Akira Nakazono, Takayoshi Suzuki, Shinichiro Yasukawa, Akihiro Homma
BACKGROUND: The revised 8th edition of the AJCC/UICC staging system was released in January 2017, and depth of invasion (DOI) was added to the new criteria for T classification in oral cavity cancer. In this study, we evaluated whether the 8th edition presents the prognosis and risk of nodal metastasis in patients with squamous cell carcinoma of tongue more accurately than did the 7th edition. METHODS: The data for 112 patients were obtained and reclassified based on the criteria presented in the 8th edition...
April 19, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29673737/epidemiological-features-of-cancers-of-the-oral-cavity-oropharynx-hypopharynx-and-larynx-cancer-in-r%C3%A3-union-island
#17
A Delagranda, G Leterme, E Chirpaz, C Ferdynus, C Fernandez, F Rubin
INTRODUCTION: This study had two objectives: firstly, to identify and compare characteristics of cancer of the oral cavity, oropharynx, hypopharynx and larynx in Réunion Island, a tropical French overseas territory in the southern hemisphere; and secondly, to discuss how incidence of these cancers is presented in the international literature. MATERIAL AND METHOD: A retrospective study included 599 patients diagnosed with cancer of the oral cavity, oropharynx, hypopharynx or larynx between 2009 and 2013 in Réunion Island...
April 16, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29672933/anti-angiogenic-efficacy-of-aflibercept-and-bevacizumab-in-primary-oral-squamous-cell-carcinoma-cells
#18
Meysam Ganjibakhsh, Roshanak Monshizadeh, Ahmad Nasimian, Pouyan Aminishakib, Parvaneh Farzaneh, Sahar Tavakoli Shiraji, Ata Garajei, Sedigheh Rahrotaban, Fereshteh Baghaei, Neda Sadat Gohari
BACKGROUND: In recent decades, anti-angiogenic treatment strategy has been well-described in cancer treatment. The anti-angiogenic activity of both Bevacizumab and Aflibercept have been researched on ten previously established primary Oral Squamous Cell Carcinoma (OSCC) cells of an Iranian population with different levels of purity, in an attempt to find the most effective anti-angiogenic targeted drug. METHODS: To investigate and compare the effect of Bevacizumab and Aflibercept on Vascular Endothelial Growth Factor (VEGF) secretion of ten primary OSCC cells, cell proliferation and viability were assessed by ELISA and MTT assays...
April 19, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29672635/differential-transmission-of-the-molecular-signature-of-rbsp3-limd1-and-cdc25a-in-basal-parabasal-versus-spinous-of-normal-epithelium-during-head-and-neck-tumorigenesis-a-mechanistic-study
#19
Shreya Sarkar, Neyaz Alam, Syam Sundar Mandal, Kabita Chatterjee, Supratim Ghosh, Susanta Roychoudhury, Chinmay Kumar Panda
Head and neck squamous cell carcinoma (HNSCC) is a global disease and mortality burden, necessitating the elucidation of its molecular progression for effective disease management. The study aims to understand the molecular profile of three candidate cell cycle regulatory genes, RBSP3, LIMD1 and CDC25A in the basal/ parabasal versus spinous layer of normal oral epithelium and during head and neck tumorigenesis. Immunohistochemical expression and promoter methylation was used to determine the molecular signature in normal oral epithelium...
2018: PloS One
https://www.readbyqxmd.com/read/29672550/tumor-budding-is-an-independent-prognostic-marker-in-early-stage-oral-squamous-cell-carcinoma-with-special-reference-to-the-mode-of-invasion-and-worst-pattern-of-invasion
#20
Shota Shimizu, Akihiro Miyazaki, Tomoko Sonoda, Kazushige Koike, Kazuhiro Ogi, Jun-Ichi Kobayashi, Takeshi Kaneko, Tomohiro Igarashi, Megumi Ueda, Hironari Dehari, Akira Miyakawa, Tadashi Hasegawa, Hiroyoshi Hiratsuka
Pathologically proven regional lymph node metastasis affects the prognosis in early stage oral cancer. Therefore we investigated invasive tumor patterns predicting nodal involvement and survival in patients with clinically node-negative T1 and T2 oral squamous cell carcinoma (cT1,2N0M0 OSCC). Ninety-one cases of cT1,2N0M0 OSCC treated with transoral resection of the primary tumor were assessed based on 3 types of invasive tumor patterns on histopathologic and pancytokeratin-stained immunohistological sections: the mode of invasion, worst pattern of invasion (WPOI), and tumor budding...
2018: PloS One
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