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Oral squamous cell carcinoma

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https://www.readbyqxmd.com/read/29473252/transoral-radical-tonsillectomy-and-retropharyngeal-lymph-node-dissection-with-a-flexible-next-generation-robotic-surgical-system
#1
Raymond K Tsang, Eddy W Y Wong, Jason Y K Chan
BACKGROUND: The purpose of this study was to describe the use of a novel flexible, single-arm robot in performing a transoral radical tonsillectomy and retropharyngeal lymph node dissection. METHODS: A 63-year-old man with a T1N2bM0 (American Joint Committee on Cancer seventh edition classification) squamous cell carcinoma (SCC) of the left tonsil underwent a transoral robotic radical tonsillectomy and retropharyngeal lymph node dissection, followed by a left selective neck dissection of levels I to IV...
February 23, 2018: Head & Neck
https://www.readbyqxmd.com/read/29469989/density-and-location-of-cd3-and-cd8-tumor-infiltrating-lymphocytes-correlate-with-prognosis-of-oral-squamous-cell-carcinoma
#2
Chen Zhou, Yaping Wu, Lei Jiang, Zhongwu Li, Pengfei Diao, Dongmiao Wang, Wei Zhang, Laikui Liu, Yanling Wang, Hongbing Jiang, Jie Cheng, Jianrong Yang
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) are regarded as adaptive immune response of the host to cancer cells and valuable prognostic factors. Here, we sought to characterize the densities and locations of CD3+ and CD8+ TILs in primary oral squamous cell carcinoma (OSCC) samples and assess their clinicopathological and prognostic significance. METHODS: A total number of 169 OSCC samples from two independent patient cohorts (Nanjing cohort, 93 cases; Wuxi cohort, 76 cases) were retrospectively collected...
February 22, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29468726/immunohistochemical-expression-of-cd44-in-oral-squamous-cell-carcinoma-in-relation-to-histomorphologic-parameters-and-clinicopathological-factors
#3
Melanie Boxberg, Carolin Götz, Selgai Haidari, Christiane Dorfner, Moritz Jesinghaus, Enken Drecoll, Marko Boskov, Klaus Dietrich Wolff, Wilko Weichert, Bernhard Haller, Andreas Kolk
OBJECTIVES: Oral squamous cell carcinoma (OSCC) is characterized by its variable clinical course. In addition to the routinely used TNM/UICC systems, patient-specific prognostic/predictive biomarkers are needed. Promising biomarkers include the determination of the cancer stem cell (CSC) compartment, which can be identified by CD44 expression (amongst others). MATERIALS AND METHODS: A well-characterized cohort of 108 therapy-naïve OSCC with complete long-term follow-up and matched lymph node metastases were evaluated for CD44 expression by immunohistochemistry...
February 22, 2018: Histopathology
https://www.readbyqxmd.com/read/29467931/toll-like-receptor-2-induces-adenosine-receptor-a2a-and-promotes-human-squamous-carcinoma-cell-growth-via-extracellular-signal-regulated-kinases-%C3%A2
#4
Chithra Devi Palani, Lalitha Ramanathapuram, Aroonwan Lam-Ubol, Zoya B Kurago
Patient treatment for oral squamous cell carcinoma (OSCC) not associated with Human papillomavirus remains problematic. OSCC microenvironment is typically inflamed and colonized by microorganisms, providing ligands for toll-like receptors (TLR). In immune cells TLR2 and TLR4 activate NF-kB and extracellular signal regulated kinase (ERK)1/2 pathways, leading to upregulation of inhibitory adenosine receptors A2a and A2b, and reduction in stimulatory A1 and A3. How TLR and adenosine receptors function in SCC cells is not understood...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29464350/nipa-like-domain-containing-1-is-a-novel-tumor-promoting-factor-in-oral-squamous-cell-carcinoma
#5
Tomonori Sasahira, Yukiko Nishiguchi, Miyako Kurihara-Shimomura, Chie Nakashima, Hiroki Kuniyasu, Tadaaki Kirita
PURPOSE: In our previous global gene expression analysis, we identified NIPA-like domain containing 1 (NIPAL1), which encodes a magnesium transporter, as one of the most overexpressed genes in recurrent oral squamous cell carcinoma (OSCC). Although has been NIPAL1 linked with gout pathogenesis, little is known about its expression and function in human malignancies. METHODS: In this study, we examined NIPAL1 expression in 192 cases of OSCC by immunohistochemistry and performed a functional analysis of human OSCC cells...
February 20, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29464035/upregulation-of-cell-cycle-genes-in-head-and-neck-cancer-patients-may-be-antagonized-by-erufosine-s-down-regulation-of-cell-cycle-processes-in-oscc-cells
#6
Shariq S Ansari, Ashwini K Sharma, Michael Zepp, Elizabet Ivanova, Frank Bergmann, Rainer König, Martin R Berger
The TCGA database was analyzed to identify deregulation of cell cycle genes across 24 cancer types and ensuing effects on patient survival. Pan-cancer analysis showed that head and neck squamous cell carcinoma (HNSCC) ranks amongst the top four cancers showing deregulated cell cycle genes. Also, the median gene expression of all CDKs and cyclins in HNSCC patient samples was higher than that of the global gene expression. This was verified by IHC staining of CCND1 from HNSCC patients. When evaluating the quartiles with highest and lowest expression, increased CCND1/CDK6 levels had negative implication on patient survival...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29463797/induction-of-er-and-mitochondrial-stress-by-the-alkylphosphocholine-erufosine-in-oral-squamous-cell-carcinoma-cells
#7
Shariq S Ansari, Ashwini K Sharma, Himanshu Soni, Doaa M Ali, Björn Tews, Rainer König, Hansjörg Eibl, Martin R Berger
Endoplasmic reticulum (ER) plays an essential role in cell function and survival. Accumulation of unfolded or misfolded proteins in the lumen of the ER activates the unfolded protein response (UPR), resulting in ER stress and subsequent apoptosis. The alkylphosphocholine erufosine is a known Akt-mTOR inhibitor in oral squamous cell carcinoma (OSCC). In the present study, we evaluate erufosine's role to induce ER and mitochondrial stress leading to autophagy, apoptosis, and ROS induction. The cellular toxicity of erufosine was determined in two OSCC cell lines and gene expression and enrichment analyses were performed...
February 20, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29462614/tgf-%C3%AE-1-t%C3%AE-rii-smad3-signaling-pathway-promotes-vegf-expression-in-oral-squamous-cell-carcinoma-tumor-associated-macrophages
#8
Haibin Sun, Cheng Miao, Wei Liu, Xianghe Qiao, Wenbin Yang, Longjiang Li, Chunjie Li
Oral squamous cell carcinoma (OSCC) is the most common type of malignant cancer affecting the oral cavity. Tumor associated macrophages (TAMs) play a vital role in the initiation, progression and metastasis of OSCC. In this study, we investigated the correlation between macrophages and several clinical and pathological indicators, and we also explored how transforming growth factor-β1 (TGF-β1) effect on VEGF expression in TAMs. Seventy-two paraffin-embedded OSCC samples were collected. Association between macrophages density, micro vascular density (MVD) and clinical-pathological feature were explored by immunohistochemical staining...
February 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29462183/galanin-is-an-epigenetically-silenced-tumor-suppressor-gene-in-gastric-cancer-cells
#9
Daseul Yoon, Kieun Bae, Min-Kyeong Lee, Jin Hee Kim, Kyong-Ah Yoon
Galanin is a 30 amino-acid active neuropeptide that acts via three G-protein coupled galanin receptors, GALR1, GALR2 and GALR3. Recently, GALR1 was also suggested as a tumor suppressor gene that was frequently silenced in head and neck squamous cell carcinoma; moreover, galanin and GALR1 were reported to inhibit human oral cancer cell proliferation. However, the exact role of galanin in gastric cancer is unclear. Here, we describe the epigenetic silencing of galanin in human gastric cancer. Five gastric cancer cell lines (SNU-1, SNU-601, SNU-638, KATOIII, and AGS) showed a significant reduction in galanin expression that was restored by the demethylating agent 5-aza-2'-deoxycytidine...
2018: PloS One
https://www.readbyqxmd.com/read/29461673/identification-of-scara5-as-a-potential-biomarker-for-oral-squamous-cell-carcinoma-using-maldi-tof-ms-analysis
#10
Ying Liu, Yi-Ran Tan, Wen-Wen Sun, Wu-Tong Ju, Yong Fu, Li-Zhen Wang, Jiang Li, Chen-Ping Zhang, Zhi-Yuan Zhang, Lai-Ping Zhong
PURPOSE: To find the potential biomarkers in in the diagnostic model of oral and squamous cell carcinoma (OSCC), and to further validate the biomarker. EXPERIMENTAL DESIGN: With the MALDI-TOF-MS analysis between tissues from oral cancer patients and normal oral mucosa from healthy controls, scara5 was found to be potentially significant after searching the protein database. In addition, Immunohistochemical staining, PCR, ELISA and western blot technique were used to detect scara5 expression in clinical samples and cell lines...
February 20, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29461377/total-lower-lip-reconstruction-with-functional-gracilis-free-muscle-flap
#11
Mehmet Akif Cakmak, Hakan Cinal, Ensar Zafer Barin, Muhammed Sedat Sakat, Harun Karaduman, Onder Tan
Free flaps based on static slings principles cannot provide esthetic and functional outcomes at a desired level in total or close to total lip loss. Therefore, dynamic methods have become a current issue in recent years and especially the idea of functional gracilis free muscle flap has been suggested. In this study, we present a case of a successful total lower lip repair with this flap.In a 78-year-old female patient who was diagnosed with squamous cell carcinoma involving the entire lower lip, bilateral modified radical neck dissection and full-thickness total resection with 1 cm surgical margin so as to include both commissures of the tumor were performed and then a free gracilis muscle flap was transferred from the same side...
February 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29460539/human-polyomavirus-in-tonsillar-microbiota-of-an-afghan-population-group
#12
F Ruggiero, D Carbone, R Mugavero, A Palmieri, D Lauritano, L Baggi, M Nardone, M Martinelli, F Carinci
Some studies have evidenced the role of human polyomaviruses in head and neck squamous cell carcinoma. BK, JC and SV40 human polyoma viruses are widely recognized as etiological agents associated with malignancies. The aim of this study was to analyse the prevalence of BK, IC and SV40 in tonsillar microbiota in a group of Afghan volunteers. A sample of the tonsillar microbiota was taken from a single site using a sterile oral swab paper stick. A fixed volume of purified DNA from each sample was tested by quantitative real-time polymerase chain reactions to evaluate the number of human cells and the number of viral genomes in each sample...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29460521/hpv-acting-on-e-cadherin-p53-and-p16-literature-review
#13
L Ottria, V Candotto, F Cura, L Baggi, C Arcuri, M Nardone, R M Gaudio, R Gatto, F Spadari, F Carinci
In addition to tobacco and alcohol consumption, the two main risk factors for oral squamous cell carcinoma (OSCC), recent studies have revealed infections with human papilloma virus (HPV) as an additional risk factor for OSCC development. In the field of head and neck malignancies, the prevalence of HPV infections in oropharyngeal cancer (OC) ranges in different studies up to 84%. While HPV infection is discussed as an independent risk factor in this region, its distinguished role in carcinogenesis of tumours localized to the oral cavity remains uncertain...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29459186/squamous-cell-carcinoma-of-the-maxilla-analysis-of-clinicopathological-predictors-for-disease-recurrence-and-metastatic-behavior
#14
Julius Moratin, Andreas Fuchs, Carolin Zeidler, Urs D A Müller-Richter, Roman C Brands, Stefan Hartmann, Alexander C Kübler, Christian Linz
INTRODUCTION: Squamous cell carcinoma of the maxilla only constitutes a small fraction of Head and Neck Cancers. There is thereby a lack of information about frequent tumor staging and localization and their effect on patients' outcome. The main factors that influence longterm survival in HNSCC are the extent of the primary disease and recurrence rate, including local neck metastases. PATIENTS AND METHODS: In this study, clinical outcome and rates of disease recurrence in 68 surgically treated patients with maxillary SCC were evaluated in terms of primary tumor staging and localization...
February 2, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29457565/current-status-and-future-perspectives-in-canine-oral-squamous-cell-carcinoma
#15
Lisa A Mestrinho
No abstract text is available yet for this article.
March 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29456966/metabolic-profile-of-oral-squamous-carcinoma-cell-lines-relies-on-a-higher-demand-of-lipid-metabolism-in-metastatic-cells
#16
Ana Carolina B Sant'Anna-Silva, Gilson C Santos, Samir P Costa Campos, André Marco Oliveira Gomes, Juan Alberto Pérez-Valencia, Franklin David Rumjanek
Tumor cells are subjected to a broad range of selective pressures. As a result of the imposed stress, subpopulations of surviving cells exhibit individual biochemical phenotypes that reflect metabolic reprograming. The present work aimed at investigating metabolic parameters of cells displaying increasing degrees of metastatic potential. The metabolites present in cell extracts fraction of tongue fibroblasts and of cell lines derived from human tongue squamous cell carcinoma lineages displaying increasing metastatic potential (SCC9 ZsG, LN1 and LN2) were analyzed by1 H NMR (nuclear magnetic resonance) spectroscopy...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29456845/low-carbonyl-reductase-1-expression-is-associated-with-poor-prognosis-in-patients-with-oral-squamous-cell-carcinoma
#17
Ryota Yamanouchi, Koji Harada, Tarannum Ferdous, Yoshiya Ueyama
Carbonyl reductase 1 (CBR1) is an enzyme that catalyzes the reduction of numerous compounds by using NADPH-dependent oxidoreductase activity. Decreased expression of CBR1 is associated with disease progression and an unfavorable outcome in several types of malignancies. The purpose of the current study was to determine whether CBR1 expression could be a useful prognostic factor in patients with oral squamous cell carcinoma (OSCC). Therefore, its mechanisms of action were investigated in order to understand how CBR1 affects cancer cell behavior in vitro ...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29456091/frequency-of-human-papillomavirus-infection-in-patients-with-gastrointestinal-cancer
#18
F Roesch-Dietlen, A D Cano-Contreras, Y J Sánchez-Maza, J M Espinosa-González, M Á Vázquez-Prieto, E J Valdés-de la O, F Díaz-Roesch, M Á Carrasco-Arroniz, A Cruz-Palacios, P Grube-Pagola, A Sumoza-Toledo, H Vivanco-Cid, G Mellado-Sánchez, A Meixueiro-Daza, C S Silva-Cañetas, M G Carrillo-Toledo, R Lagunes-Torres, M Amieva-Balmori, P C Gómez-Castaño, J U Reyes-Huerta, J M Remes-Troche
INTRODUCTION AND AIM: Cancer is the result of the interaction of genetic and environmental factors. It has recently been related to viral infections, one of which is human papillomavirus. The aim of the present study was to describe the frequency of human papillomavirus infection in patients with digestive system cancers. MATERIALS AND METHODS: A prospective, multicenter, observational study was conducted on patients with gastrointestinal cancer at 2public healthcare institutes in Veracruz...
February 15, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29454310/in-vitro-and-in-silico-validation-of-ca3-and-fhl1-downregulation-in-oral-cancer
#19
Cláudia Maria Pereira, Ana Carolina de Carvalho, Felipe Rodrigues da Silva, Matias Eliseo Melendez, Roberta Cardim Lessa, Valéria Cristina C Andrade, Luiz Paulo Kowalski, André L Vettore, André Lopes Carvalho
BACKGROUND: Aberrant methylation is a frequent event in oral cancer. METHODS: In order to better characterize these alterations, a search for genes downregulated by aberrant methylation in oral squamous cell carcinoma (OSCC) was conducted through the mining of ORESTES dataset. Findings were further validated in OSCC cell lines and patients' samples and confirmed using TCGA data. Differentially expressed genes were identified in ORESTES libraries and validated in vitro using RT-PCR in HNSCC cell-lines and OSCC tumor samples...
February 17, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29453969/s100-proteins-in-oral-squamous-cell-carcinoma
#20
REVIEW
Muhammad Arsalan Raffat, Naila Irum Hadi, Mervyn Hosein, Sana Mirza, Sana Ikram, Zohaib Akram
BACKGROUND: Controversy exists in the literature regarding the differential expression of S100 protein members and their functional correlations in oral squamous cell carcinoma (OSCC). The aim of the present study was to systematically review the expression of S100 protein family members among OSCC and healthy controls and to evaluate whether S100 protein members serve as diagnostic marker in OSCC. METHODS: Indexed databases were searched up to and including October 2017...
February 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
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