keyword
MENU ▼
Read by QxMD icon Read
search

Oral squamous cell carcinoma

keyword
https://www.readbyqxmd.com/read/29232177/metformin-effects-on-metabolic-coupling-and-tumor-growth-in-oral-cavity-squamous-cell-carcinoma-coinjection-xenografts
#1
Patrick Tassone, Marina Domingo-Vidal, Diana Whitaker-Menezes, Zhao Lin, Megan Roche, Madalina Tuluc, Ubaldo Martinez-Outschoorn, Joseph Curry
Objective Many aggressive head and neck cancers contain 2 metabolically coupled tumor compartments: a glycolytic stromal compartment with low caveolin-1 (CAV1) and high monocarboxylate transporter 4 (MCT4) expression and a highly proliferative carcinoma cell compartment with high MCT1. Metabolites are shuttled by MCTs from stroma to carcinoma to fuel tumor growth. We studied the effect of carcinoma-fibroblast coinjection and metformin administration on a mouse model of head and neck squamous cell carcinoma...
December 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29228709/targeting-lncrna-hotair-suppresses-cancer-stemness-and-metastasis-in-oral-carcinomas-stem-cells-through-modulation-of-emt
#2
Ming-Yi Lu, Yi-Wen Liao, Pei-Yin Chen, Pei-Ling Hsieh, Chih-Yuan Fang, Chia-Yu Wu, Ming-Liang Yen, Bou-Yue Peng, Dayen Peter Wang, Hsin-Chung Cheng, Ching-Zong Wu, Yung-Hsun Shih, Duen-Jeng Wang, Cheng-Chia Yu, Lo-Lin Tsai
Increasing evidence indicates that long non-coding RNAs (lncRNAs) regulate diverse cellular processes, such as cell growth, apoptosis and tumorigenesis. However, the functional roles of lncRNAs and mechanistic analysis of their interplays with oncogenic pathways in oral cancer remain largely unknown. In the current study, we examined the significance of lncRNA HOTAIR (HOX transcript antisense RNA) in tumor progression of oral squamous cell carcinomas (OSCC). We found the expression of HOTAIR was upregulated in tumor tissues, especially in the metastatic samples...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228609/bacteriome-and-mycobiome-associations-in-oral-tongue-cancer
#3
Pranab K Mukherjee, Hannah Wang, Mauricio Retuerto, Huan Zhang, Brian Burkey, Mahmoud A Ghannoum, Charis Eng
Squamous cell carcinoma of the oral (mobile) tongue (OMTC), a non-human papilloma virus-associated oral cancer, is rapidly increasing without clear etiology. Poor oral hygiene has been associated with oral cancers, suggesting that oral bacteriome (bacterial community) and mycobiome (fungal community) could play a role. While the bacteriome is increasingly recognized as an active participant in health, the role of the mycobiome has not been studied in OMTC. Tissue DNA was extracted from 39 paired tumor and adjacent normal tissues from patients with OMTC...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227794/does-different-mandibulectomy-marginal-vs-segmental-affect-the-prognosis-in-patients-with-oral-squamous-cell-carcinoma
#4
Yu Qiu, Lisong Lin, Bin Shi, Xiaofeng Zhu
PURPOSE: It is unclear whether different mandibular surgical methods affect the prognosis of patients with oral squamous cell carcinoma (OSCC). Accordingly, the authors retrospectively compared the prognosis of patients who underwent marginal mandibulectomy (MG) or segmental mandibulectomy (SG) for OSCC and aimed to determine the factors influencing prognosis. MATERIALS AND METHODS: The authors conducted a retrospective cohort study of 82 patients with OSCC who underwent mandibulectomy at their hospital from January 2001 through January 2015...
November 21, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29227715/human-papillomavirus-genome-integration-and-head-and-neck-cancer
#5
L M Pinatti, H M Walline, T E Carey
We conducted a critical review of human papillomavirus (HPV) integration into the host genome in oral/oropharyngeal cancer, reviewed the literature for HPV-induced cancers, and obtained current data for HPV-related oral and oropharyngeal cancers. In addition, we performed studies to identify HPV integration sites and the relationship of integration to viral-host fusion transcripts and whether integration is required for HPV-associated oncogenesis. Viral integration of HPV into the host genome is not required for the viral life cycle and might not be necessary for cellular transformation, yet HPV integration is frequently reported in cervical and head and neck cancer specimens...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29227548/resistance-of-oral-cancer-cells-to-5-ala-mediated-photodynamic-therapy
#6
Flávia Cristina Perillo Rosin, Marina Gabriela Teixeira, Cibele Pelissari, Luciana Corrêa
Photodynamic therapy (PDT) has been indicated for oral squamous cell carcinoma (OSCC) at early stages. Chemo and radio-resistance are frequently observed in OSCC, but it is unknown whether this tumor can develop resistance to PDT. It was investigated the process of acquiring resistance to multiple cycles of PDT by using OSCC cells. We also analyzed the expression of anti-apoptotic proteins and those related to Akt/mTOR pathway. Sub-lethal doses of PDT were applied, consisting of a constant concentration of 5-aminolevulinic acid (5-ALA) (1 mM, 4-hour incubation) and increasing irradiation dose with LED (from 5...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29226639/early-diagnosis-of-oral-squamous-cell-carcinoma-by-salivary-micrornas
#7
REVIEW
Raluca Dumache
BACKGROUND: Oral squamous cell carcinoma (OSCC), the most common type of oral cancer, and represents more than 90% of malignancies of the oral cavity. Worldwide, each year about 275,000 are newly diagnosed. If detected at an early stage, OSCC has a survival rate of up to 80% compared to the detection in later stages (T3-T4) when a survival rate of 20 - 30% is present. METHODS: Because OSCC presents these survival rates, there is an urgent need to introduce new non-invasive molecular biomarkers for the early detection of OSCC from saliva, which will contribute to an increased long term survival rate for these patients...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29226456/cigarette-smoke-extract-induces-oral-squamous-cell-carcinoma-cell-invasion-in-a-receptor-for-advanced-glycation-end-products-dependent-manner
#8
Steven Chapman, Madison Mick, Parker Hall, Camilo Mejia, Stephanie Sue, Bihishta Abdul Wase, Margaret A Nguyen, Evan C Whisenant, Shalene H Wilcox, Duane Winden, Paul R Reynolds, Juan A Arroyo
Oral squamous cell carcinoma (OSCC) affects approximately 30,000 people and is associated with tobacco use. Little is known about the mechanistic effects of second-hand smoke in the development of OSSC. The receptor for advanced glycation end-products (RAGE) is a surface receptor that is upregulated by second-hand smoke and inhibited by semi-synthetic glycosaminoglycan ethers (SAGEs). Our objective was to determine the role of RAGE during cigarette smoke extract-induced cellular responses and to use SAGEs as a modulating factor of Ca9-22 OSCC cell invasion...
December 11, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29225081/enteral-nutrition-and-quality-of-life-in-patients-undergoing-chemoradiotherapy-for-esophageal-carcinoma-a-comparison-of-nasogastric-tube-esophageal-stent-and-ostomy-tube-feeding
#9
Fang-Jung Yu, Hsiang-Yao Shih, Chien-Yi Wu, Yun-Shiuan Chuan, Jui-Ying Lee, Hsien-Pin Li, Pen-Tzu Fang, Dong-Lin Tsai, Shah-Hwa Chou, I-Chen Wu
BACKGROUND AND AIMS: This study prospectively recruited esophageal squamous-cell carcinoma patients who received esophageal stent, nasogastric tube (NG) or jejunostomy/gastrostomy feeding to compare the changes in nutritional status and quality of life during chemoradiation therapy (CRT). METHODS: In total, 81 patients were analyzed (stent 7, surgical ostomy 26, NG 19, oral intake 29). NG was inserted when despite medication dysphagia or pain worsened with oral feeding during CRT...
December 7, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29224831/reconstruction-of-oral-cavity-defect-using-versatile-buccinator-myomucosal-flaps-in-the-treatment-of-ct2-3-n0-oral-cavity-squamous-cell-carcinoma-feasibility-morbidity-and-functional-oncological-outcomes
#10
Dongbin Ahn, Gil Joon Lee, Jin Ho Sohn
OBJECTIVES: To evaluate the results of oral cavity reconstruction using various types of buccinator myomucosal flap (BMMF) for the treatment of cT2-3 oral cavity squamous cell carcinoma (OCSCC). MATERIALS AND METHODS: Twenty-two consecutive patients who underwent surgical management for OCSCC and reconstruction using various types of BMMF were enrolled. Surgical results, complications, speech/swallowing outcomes, and recurrence were evaluated. RESULTS: The mean flap harvest time was 28...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29224821/a-multicenter-study-of-malignant-oral-and-maxillofacial-lesions-in-children-and-adolescents
#11
José Alcides Almeida de Arruda, Leni Verônica de Oliveira Silva, Camila de Nazaré Alves de Oliveira Kato, Lauren Frenzel Schuch, Aline Carvalho Batista, Nádia Lago Costa, Sandra Beatriz Chaves Tarquinio, Elena Riet Correa Rivero, Vinícius Coelho Carrard, Manoela Domingues Martins, Ana Paula Veras Sobral, Ricardo Alves Mesquita
OBJECTIVES: To investigate the frequency of malignant oral and maxillofacial lesions among children and adolescents from representative geographic regions of Brazil. MATERIALS AND METHODS: A retrospective study was conducted on biopsies obtained from 1990 to 2016 at six Brazilian oral and maxillofacial pathology referral centers. A total of 85,105 biopsy specimens from children and adolescents were analyzed. Gender, age, anatomical location, symptomatology and histopathological diagnosis were evaluated...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29224816/hypermethylated-znf582-and-pax1-genes-in-oral-scrapings-collected-from-cancer-adjacent-normal-oral-mucosal-sites-are-associated-with-aggressive-progression-and-poor-prognosis-of-oral-cancer
#12
Shih-Jung Cheng, Chi-Feng Chang, Hui-Hsin Ko, Yi-Ching Liu, Hsin-Hui Peng, Huei-Jen Wang, Hsiao-Shan Lin, Chun-Pin Chiang
OBJECTIVE: This study assessed whether hypermethylated ZNF582 and PAX1 genes in oral scrapings are correlated with the progression and prognosis of oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: Methylation levels of ZNF582 and PAX1 genes in oral scrapings, collected from the cancer and adjacent normal oral mucosal sites of 80 OSCC patients before surgical cancer excision, were quantified using real-time methylation-specific PCR after bisulfite conversion...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29224815/definitive-chemo-radiotherapy-is-a-curative-alternative-for-standard-of-care-in-advanced-stage-squamous-cell-carcinoma-of-the-oral-cavity
#13
Joris B W Elbers, Abrahim Al-Mamgani, Danique Paping, Michiel W M van den Brekel, Katarzyna Jóźwiak, J P de Boer, Baris Karakullukcu, Marcel Verheij, Charlotte L Zuur
OBJECTIVE: To compare outcome after definitive (chemo)radiotherapy (CRT group) with standard of care (surgery group) for advanced stage oral cavity carcinoma (OCC). Although definitive (chemo)radiotherapy is assumed to be inferior to surgery with regard to disease control, data on outcome of this approach are scarce. METHODS: Retrospective analysis by chart review (2000-2013). Endpoints were locoregional control (LRC), disease-free survival (DFS), disease specific survival (DSS) and overall survival (OS)...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29224812/differential-roles-of-kallikrein-related-peptidase-6-in-malignant-transformation-and-%C3%AE-np63%C3%AE-mediated-epithelial-mesenchymal-transition-of-oral-squamous-cell-carcinoma
#14
Naoki Kaneko, Shintaro Kawano, Kaori Yasuda, Yuma Hashiguchi, Taiki Sakamoto, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Masahiko Morioka, Taichi Hattori, Shoichi Tanaka, Hideaki Tanaka, Tamotsu Kiyoshima, Seiji Nakamura
We previously reported that epithelial-to-mesenchymal transition (EMT) was mediated by ΔNp63β in oral squamous cell carcinoma (OSCC). In this study, DNA microarray analyses were performed using ΔNp63β-overexpressing OSCC cells to identify genes associated with ΔNp63β-mediated EMT. Thereby, we focused on kallikrein-related peptidase (KLK) 6, most up-regulated following ΔNp63β-overexpression, that activates protease-activated receptors (PARs). In RT-PCR analyses, ΔNp63 was positively associated with KLK6 and PAR2 and negatively with PAR1 in OSCC cells...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29224043/identification-of-human-papillomavirus-hpv-subtype-in-oral-cancer-patients-through-microarray-technology
#15
Soung Min Kim, Ik Jae Kwon, Hoon Myoung, Jong Ho Lee, Suk Keun Lee
PURPOSE: Human papilloma virus (HPV) is the main source of cervical cancer. Many recent studies have revealed the prevalence and prognosis of HPV associated with oropharyngeal squamous cell carcinoma, but fewer reports have evaluated HPV in oral squamous cell carcinoma (OSCC). The purpose of this study was to determine the prevalence and prognosis of HPV associated with OSCC according to HPV and tumor types. MATERIALS AND METHODS: We used a DNA chip kit (MY-HPV chip kit ®, Mygene Co...
December 9, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29221949/anti-cancer-activity-of-a-new-dihydropyridine-derivative-vdie-2n-in-head-and-neck-squamous-cell-carcinoma
#16
Renata Nishida Goto, Lays Martin Sobral, Lucas Oliveira Sousa, Cristiana Bernadelli Garcia, Norberto Peporine Lopes, Javier Marín-Prida, Estael Ochoa-Rodríguez, Yamila Verdecia-Reyes, Gilberto Lázaro Pardo-Andreu, Carlos Curti, Andréia Machado Leopoldino
This study aims to examine the effects of a new 1,4-dihydropyridine derivative, VdiE-2N, on cell signaling pathways and mitochondrial events in head and neck squamous cell carcinoma (HNSCC) cells, and on a mice model of xenograft tumor growth/cell proliferation. Four HNSCC cell lines (HN13, HN12, HN6, and CAL27), HEK293 cells (human embryonic kidney 293 cells), and human oral healthy mucosa fibroblasts (OHMF) were used for in vitro assessment of cell viability (resazurin assay) and invasion capacity (modified Boyden chamber assay), and mitochondrial membrane potential (JC-1 fluorescence assay), morphology (transmission electron microscopy), and number of mitochondria (MitoTracker® imaging)...
December 6, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29221201/functional-fgfr4-gly388arg-polymorphism-contributes-to-oral-squamous-cell-carcinoma-susceptibility
#17
Chia-Hsuan Chou, Ming-Ju Hsieh, Chun-Yi Chuang, Jen-Tsun Lin, Chia-Ming Yeh, Pao-Yu Tseng, Shun-Fa Yang, Mu-Kuan Chen, Chiao-Wen Lin
Aberrations of the fibroblast growth factor receptor 4 (FGFR4) genomic region include amplification of FGFR4, activation of FGFR4 kinase domain mutations, and overexpression of FGFR4, which lead to sustained cell proliferation and contribute to tumor development. However, the association between FGFR4 single-nucleotide polymorphisms (SNPs) and risk of oral squamous cell carcinoma (OSCC) remains to be determined. We investigated the relationships between FGFR4 genetic polymorphisms, OSCC development and clinicopathological variables...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218012/anti-tumor-effect-of-rhaponticum-uniflorum-ethyl-acetate-extract-by-regulation-of-peroxiredoxin1-and-epithelial-to-mesenchymal-transition-in-oral-cancer
#18
Hui Chen, Chunxiao Wang, Moci Qi, Lihua Ge, Zhenchuan Tian, Jinhua Li, Min Zhang, Min Wang, Linfang Huang, Xiaofei Tang
Objective: To explore whether Rhaponticum uniflorum (R. uniflorum) had anti-tumor effects in oral cancer and investigate the molecular mechanisms involved in these anti-tumor effects. Methods: Chemical compositions of R. uniflorum ethyl acetate (RUEA) extracts were detected by ultra-performance liquid chromatography-Q/time-of-flight mass spectrometry (UPLC-Q/TOF-MS), followed by pharmacology-based network prediction analysis. The effects of RUEA extracts on proliferation, apoptosis, migration, and invasion ability of human oral squamous cell carcinoma (OSCC) cell line SCC15 were evaluated by CCK8 assay, Annexin V- fluorescein isothiocyanate/propidium iodide staining, wound healing assay, and Matrigel invasion assay, respectively...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29216196/loss-of-epithelial-markers-is-an-early-event-in-oral-dysplasia-and-is-observed-within-the-safety-margin-of-dysplastic-and-t1-oscc-biopsies
#19
Zahra Abdalla, Tanya Walsh, Nalin Thakker, Christopher M Ward
Oral squamous cell carcinoma (OSCC) is a highly aggressive cancer that is associated with poor 5-year patient survival. Disease treatment is further compounded by the difficulty in predicting pre-cancerous tissues that will progress to OSCC and the high recurrence rates following surgical resection. Here we have assessed expression of the oral epithelial markers E-cadherin, EMP1 and 5T4 and the pro-invasive N-cadherin proteins using fully characterised antibodies and quantitative immunofluorescence microscopy in normal tissue (NT), fibroepithelial polyp (FEP), low-grade dysplasia (LGD), high-grade dysplasia (HGD), T1 OSCC and T4 OSCC biopsies...
2017: PloS One
https://www.readbyqxmd.com/read/29215771/p16-positivity-and-regression-grade-predict-survival-after-neoadjuvant-radiotherapy-of-oscc
#20
Christina Eder-Czembirek, Irene Sulzbacher, Thorsten Fuereder, Edgar Selzer
OBJECTIVES: Survival after preoperative radiotherapy in locally advanced head and neck squamous cell cancer is associated with pathological response. The prognostic importance of p16 expression in these patients has not been established yet. MATERIALS AND METHODS: Ninety-seven oral squamous cell carcinoma patients, treated preoperatively with radiotherapy in combination with chemotherapy or cetxuximab, were included in this retrospective analysis. Survival rates were estimated by the Kaplan-Meyer method...
December 7, 2017: Oral Diseases
keyword
keyword
10490
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"