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Irritable bowel syndrome

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https://www.readbyqxmd.com/read/29345401/are-characteristics-of-abdominal-pain-helpful-to-identify-patients-with-visceral-hypersensitivity-in-irritable-bowel-syndrome-results-of-a-prospective-study
#1
C Melchior, L Bril, A-M Leroi, G Gourcerol, P Ducrotté
BACKGROUND: Some consider that patients with visceral hypersensitivity may represent a separate entity within the IBS population not only from a pathophysiological but also from a clinical perspective. The aim of this prospective exploratory study was to assess whether characteristics of abdominal pain in IBS patients could be suggestive of hypersensitivity. METHODS: This prospective study included consecutive IBS patients selected by Rome III criteria. Validated scores (IBS-SSS, Bristol stool scale, HADS) were used to phenotype patients who were also asked to describe the main location of their abdominal pain on a simple image (abdomen divided into 6 zones)...
January 18, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29345159/weighing-in-on-the-risks-and-benefits-of-probiotic-use-in-hiv-infected-and-immunocompromised-populations
#2
A U Happel, S L Barnabas, R Froissart, J S Passmore
Probiotics are used in the prophylaxis and treatment of several conditions, including irritable bowel syndrome, diarrhoea, necrotising enterocolitis (NEC) and colic in infants. Despite the long history of probiotic use in humans, there is still significant debate about their efficacy and safety, particularly in HIV-infected and immunocompromised individuals. Here, we reviewed the safety and adverse event (AE) reporting from clinical trials that have tested probiotics in at risk populations, including HIV-infected individuals, the terminally ill and elderly, and neonates...
January 18, 2018: Beneficial Microbes
https://www.readbyqxmd.com/read/29345029/high-prevalence-and-functional-effects-of-serum-antineuronal-antibodies-in-patients-with-gastrointestinal-disorders
#3
A Lütt, K Michel, D Krüger, M S Volz, M Nassir, E Schulz, L Poralla, P Tangermann, C Bojarski, M Höltje, B Teegen, W Stöcker, M Schemann, B Siegmund, H Prüss
BACKGROUND: Antineuronal antibodies can be associated with both gastrointestinal (GI) and brain disorders. For example, antibodies against the potassium channel subunit dipeptidyl-peptidase-like protein-6 (DPPX) bind to neurons in the central nervous system (CNS) and myenteric plexus and cause encephalitis, commonly preceded by severe unspecific GI symptoms. We therefore investigated the prevalence of antineuronal antibodies indicative of treatable autoimmune CNS etiologies in GI patients...
January 18, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29338982/involvement-of-peripheral-alpha2a-adrenoceptor-in-the-acceleration-of-gastrointestinal-transit-and-abdominal-visceral-pain-induced-by-intermittent-deprivation-of-rem-sleep
#4
Fukie Yaoita, Masamichi Muto, Hiroki Murakami, Shiori Endo, Mifuyu Kozawa, Masahiro Tsuchiya, Takeshi Tadano, Koichi Tan-No
Many studies have associated sleep alterations with the severity of irritable bowel syndrome (IBS) symptoms, but the direct pathophysiological relationship has not been clarified. In addition, alterations in noradrenergic signaling have been implicated in the pathophysiology of IBS, and alpha2-adrenoceptors are potential treatment targets. We have previously shown that acceleration of gastrointestinal transit (GIT) elicited by intermittent rapid eye movement (REM) sleep deprivation stress may fulfill the profile of a model of IBS...
January 12, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29336079/the-low-fodmap-diet-in-the-management-of-irritable-bowel-syndrome-an-evidence-based-review-of-fodmap-restriction-reintroduction-and-personalisation-in-clinical-practice
#5
REVIEW
K Whelan, L D Martin, H M Staudacher, M C E Lomer
Dietary restriction of fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) is effective in the management of functional gastrointestinal symptoms that occur in irritable bowel syndrome (IBS). Numerous reviews have been published regarding the evidence for their restriction in the low FODMAP diet; however, few reviews discuss the implementation of the low FODMAP diet in practice. The aim of this review is to provide practical guidance on patient assessment and the implementation and monitoring of the low FODMAP diet...
January 15, 2018: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/29333891/therapeutic-potential-of-zataria-multiflora-boiss-in-treatment-of-irritable-bowel-syndrome-ibs
#6
Mohaddese Mahboubi
Irritable Bowel syndrome (IBS), the most common chronic functional gastrointestinal disorder, is categorized as IBS-C and IBS-D, which are equivalent to Ghoolenj Rihi and Maghs Rihi in Iranian traditional medicine. One of the main applications of Zataria multiflora Boiss in traditional medicine is its efficacy in the gastrointestinal tract with symptoms such as IBS. The aim of this study was to evaluate the efficacy of Zataria multiflora essential oil in management of IBS. We used all the accessible references (electronic and published books, theses, and reports) to write this article...
January 15, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29332637/pilot-rct-of-an-integrative-group-therapy-for-patients-with-refractory-irritable-bowel-syndrome-isrctn02977330
#7
S Berens, E Stroe-Kunold, F Kraus, J Tesarz, A Gauss, B Niesler, W Herzog, R Schaefert
OBJECTIVE: Different forms of psychotherapeutic treatments have been proven effective in irritable bowel syndrome (IBS), but disorder-oriented and integrative concepts are still rare. Therefore, we implemented and evaluated an integrative group therapeutic concept within an interdisciplinary tertiary care clinic for functional gastrointestinal disorders (FGIDs). AIMS: present our integrative group concept, assess feasibility issues, and evaluate efficacy. METHODS: A pilot-RCT with a randomized controlled wait-listed group design was conducted...
February 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29332625/positive-and-negative-affect-mediate-the-bidirectional-relationship-between-emotional-processing-and-symptom-severity-and-impact-in-irritable-bowel-syndrome
#8
Alice Sibelli, Trudie Chalder, Hazel Everitt, Joseph Chilcot, Rona Moss-Morris
INTRODUCTION: Individuals with IBS report higher levels of psychological distress compared to healthy controls. Distress has been associated with emotional processing difficulties but studies have not explored how the relationship between distress and emotional processing affects IBS. There is little research on the role of positive affect (PA) in IBS. AIMS: (a) If difficulties in self-reported emotional processing are associated with affect and IBS measures (i...
February 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29329362/clostridium-butyricum-regulates-visceral-hypersensitivity-of-irritable-bowel-syndrome-by-inhibiting-colonic-mucous-low-grade-inflammation-through-its-action-on-nlrp6
#9
Kejia Zhao, Leimin Yu, Xi Wang, Yibo He, Bin Lu
Visceral hypersensitivity induced by stress is quite common in irritable bowel syndrome (IBS) patients. Probiotics play an important role in reducing visceral hypersensitivity in IBS patients. However, the mechanism has not been clearly elucidated. In this study, we investigated the role of nod-like receptor pyrin domain-containing protein 6 (NLRP6) in Clostridium butyricum-regulated IBS induced by stress. Our results showed that NLRP6 was down-regulated in IBS group colon tissues. In addition, IL-18, IL-1β, myeloperoxidase (MPO), d-lactic acid (D-LA), and CD172a were up-regulated in the IBS group of colonic mucous...
January 10, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29327820/gastroenterology-today-between-certainties-and-news-a-meeting-held-in-turin-on-may-27-2017
#10
Rinaldo Pellicano, Davide G Ribaldone, Marco Astegiano, Luca Dughera, Edda Battaglia, Anna Morgando, Arrigo Arrigoni, Mauro Spandre, Mario Grassini, Giorgio M Saracco, Francis Mégraud
This special article reports on two crucial issues discussed during a meeting. The first was the updated management of Helicobacter pylori infection. This was approached taking into account the recent European Guidelines, with a focus on novelties in treatment. In particular, considering the increasing H. pylori antibiotic resistance to clarithromycin, in countries with a high clarithromycin resistance rate the bismuth-containing quadruple therapies should be preferred. The new formulation, with bismuth, metronidazole, and tetracycline contained in a single capsule (three-in-one), has shown exciting results both in naive and in non-responder patients...
January 10, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29327358/opioid-medication-use-in-patients-with-gastrointestinal-diagnoses-vs-unexplained-gastrointestinal-symptoms-in-the-us-veterans-health-administration
#11
G S Sayuk, N Kanuri, C P Gyawali, B M Gott, B D Nix, R A Rosenheck
BACKGROUND: While opioid prescriptions have increased alarmingly in the United States (US), their use for unexplained chronic gastrointestinal (GI) pain (eg, irritable bowel syndrome) carries an especially high risk for adverse effects and questionable benefit. AIM: To compare opioid use among US veterans with structural GI diagnoses (SGID) and those with unexplained GI symptoms or functional GI diagnoses (FGID), a group for whom opioids have no accepted role. METHODS: Veterans Health Administration (VHA) administrative data from fiscal year 2012 were used to identify veterans with diagnostic codes recorded for SGID and FGID...
January 12, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29325791/the-therapeutic-effects-of-cannabis-and-cannabinoids-an-update-from-the-national-academies-of-sciences-engineering-and-medicine-report
#12
REVIEW
Donald I Abrams
The National Academies of Sciences, Engineering and Medicine conducted a rapid turn-around comprehensive review of recent medical literature on The Health Effects of Cannabis and Cannabinoids. The 16-member committee adopted the key features of a systematic review process, conducting an extensive search of relevant databases and considered 10,000 recent abstracts to determine their relevance. Primacy was given to recently published systematic reviews and primary research that studied one of the committee's 11 prioritized health endpoints- therapeutic effects; cancer incidence; cardiometabolic risk; respiratory disease; immune function; injury and death; prenatal, perinatal and postnatal outcomes; psychosocial outcomes; mental health; problem Cannabis use; and Cannabis use and abuse of other substances...
January 8, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29319900/laypersons-knowledge-and-perceptions-of-irritable-bowel-syndrome-as-potential-barriers-to-care
#13
LeeAnne B Sherwin
AIMS: To describe the layperson's knowledge and perceptions regarding the aetiology, pathogenesis, prevalence, medical evaluation, diagnosis and treatment of Irritable Bowel Syndrome. BACKGROUND: Diagnosis acceptance and adherence to treatment is influenced by the views of the patient's social networks. Little is known how these networks influence those with Irritable Bowel Syndrome. DESIGN: Cross-sectional study of two-hundred four laypersons, ages 18-80 years without an Irritable Bowel Syndrome diagnosis...
January 10, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29319191/linaclotide-in-irritable-bowel-syndrome-with-constipation-a-phase-3-randomized-trial-in-china-and-other-regions
#14
Yunsheng Yang, Jingyuan Fang, Xiaozhong Guo, Ning Dai, Xizhong Shen, Youlin Yang, Jing Sun, Bal Raj Bhandari, David S Reasner, Jacquelyn A Cronin, Mark G Currie, Jeffrey M Johnston, Peter Zeng, Niwat Montreewasuwat, George Zhijian Chen, Sam Lim
BACKGROUND AND AIM: Linaclotide is a guanylate cyclase-C agonist approved in multiple countries to treat irritable bowel syndrome with constipation (IBS-C). China has unmet need for well-tolerated therapy that is effective in treating both bowel and abdominal symptoms of IBS-C. This trial evaluated linaclotide's efficacy and safety in IBS-C patients in China and other regions. METHODS: This Phase 3, double-blind trial randomized IBS-C patients to once-daily oral 290-μg linaclotide or placebo at centers in China, North America, and Oceania...
January 10, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29318645/endometriosis-increased-the-risk-of-bladder-pain-syndrome-interstitial-cystitis-a-population-based-study
#15
Chia-Chang Wu, Shiu-Dong Chung, Herng-Ching Lin
OBJECTIVE: Previous studies have suggested an association between bladder pain syndrome/interstitial cystitis (BPS/IC) and endometriosis. However, no nation-wide population study has yet reported an association between them. In this study, we examined the risk of BPS/IC among subjects with endometriosis during a 3-year follow-up in Taiwan using a population-based dataset. STUDY DESIGN: This study comprised 9191 subjects with endometriosis, and 27 573 subjects randomly selected as controls...
January 10, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29317064/comparison-of-geographic-distributions-of-irritable-bowel-syndrome-with-inflammatory-bowel-disease-fail-to-support-common-evolutionary-roots-irritable-bowel-syndrome-and-inflammatory-bowel-diseases-are-not-related-by-evolution
#16
Andrew Szilagyi, Xiaoqing Xue
Irritable Bowel Syndrome (IBS) shares overlapping symptoms and some features of pathogenesis with Inflammatory Bowel Diseases (IBD: Crohn's disease [CD], and Ulcerative Colitis [UC]). Geographic markers such as latitude/sunshine and more recently lactase population distributions are found to be correlated with IBD. As a result of clinical and pathogenic similarities between the 2 conditions, some authorities questioned whether a connection exists between them. We compare IBS directly with IBD, and indirectly with geographic markers associated with IBD, in order to evaluate possible evolutionary links between IBS and IBD...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29315154/characteristics-and-comorbidities-of-inpatients-without-celiac-disease-on-a-gluten-free-diet
#17
John W Blackett, Meghana Shamsunder, Norelle R Reilly, Peter H R Green, Benjamin Lebwohl
OBJECTIVES: Despite the increasing popularity of gluten-free diet (GFD), the demographic characteristics and medical features of patients without celiac disease on this diet have not been extensively investigated.We aimed to characterize the medical conditions and demographic backgrounds of hospitalized patients without celiac disease who adhere to a GFD, to further understand their reasons for gluten avoidance. MATERIALS AND METHODS: We performed an observational cohort study on all inpatients at Columbia University Medical Center on a GFD in 2011-2016, excluding those with celiac disease, compared with age-matched and sex-matched inpatients on a regular diet...
January 8, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29314137/editorial-irritable-bowel-syndrome-in-addition-to-having-properly-trained-dietitians-is-it-time-to-add-a-yoga-teacher-to-our-multidisciplinary-team
#18
EDITORIAL
J G Muir, M Iacovou
No abstract text is available yet for this article.
February 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29314131/editorial-irritable-bowel-syndrome-in-addition-to-having-properly-trained-dietitians-is-it-time-to-add-a-yoga-teacher-to-our-multidisciplinary-team-authors-reply
#19
EDITORIAL
D Schumann, H Cramer
No abstract text is available yet for this article.
February 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29310568/ramosetron-for-the-treatment-of-irritable-bowel-syndrome-with-diarrhea-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
Qingqing Qi, Yan Zhang, Feixue Chen, Xiuli Zuo, Yanqing Li
BACKGROUND: Ramosetron is a potent and selective serotonin type 3 receptor antagonist. This meta-analysis aimed to analyze the efficacy and safety of ramosetron for irritable bowel syndrome with diarrhea (IBS-D). METHODS: Pubmed, MEDLINE, EMBASE and the Cochrane Library were searched for randomized controlled trials investigating the efficacy and safety of ramosetron for IBS-D. Risk of bias was assessed as described in the Cochrane handbook. A random effects model was used to calculate the effects of ramosetron vs placebo on symptomatic improvements, including relief of overall IBS symptoms, relief of abdominal discomfort/pain, improvement in abnormal bowel habits, and improvement in stool consistency, expressed as pooled relative risks (RRs) with 95% confidence interval (CI)...
January 8, 2018: BMC Gastroenterology
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