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Botulinium toxin

A Schneider, B Tourlonias, L Cormier, E Mourey, N Koutlidis, E Delorme, J Pasquale, I Kermarec, A-D Foahom-Kamwa, V Bonniaud
INTRODUCTION: Since 2014, OnabotulinumtoxinA Botox® (Allergan, Inc., Irvine, USA) represents a new therapeutic option for second-line treatment of idiopathic overactive bladder. The purpose of the current study was to evaluate practices of surgeons using onabotulinium toxin (BoNTA) in this indication. MATERIAL AND METHODS: All urogynecology centers of the country were asked in order to list all patients who were treated since marketing autorisation. Patient symptoms, previous treatments, paraclinic evaluations, data of surgery and the characteristics of the follow up were collected and analyzed...
March 2018: Progrès en Urologie
R Yagudina, A Kulikov, D Ugrekhelidze
No abstract text is available yet for this article.
November 2014: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
O R Orlova, M A Akulov, D Iu Usachev, S V Taniashin, V O Zakharov, E V Saksonova, L R Mingazova, S V Surovykh
AIM: To evaluate the role of botulinum toxin type A in the acute phase of facial nerve injury after neurosurgical surgery. MATERIALS AND METHODS: The study involved 55 patients with acute facial muscle paresis caused by facial nerve injury during surgery on the posterior cranial fossa and cerebello-pontine angle (CPA). The first group consisted of 35 patients (mean age, 48.14±1.26 years) who were administered botulinum toxin type A (xeomin) at a dose of 2-3 U per point in muscles of the intact side of the face...
2014: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
C Clerico, J Fernandez, O Camuzard, B Chignon-Sicard, T Ihrai
Injection of type A botulinum toxin in the armpits is a temporary treatment for axillary hyperhidrosis. This technique described in 1996 by Bushara et al., is known to be efficient and safe. The purpose of this article was to review the data concerning the treatment of axillary hyperhidrosis with botulinum toxin type A, and discuss the other treatment modalities for this socially disabling entity.
February 2016: Annales de Chirurgie Plastique et Esthétique
M Bayon-Mottu, G Gambart, X Deries, C Tessiot, I Richard, M Dinomais
OBJECTIVE: In this study, we consider two localization techniques used in injections of botulinium toxin in children: electrical stimulation and ultrasound. The hypothesis of this work was that injections performed without stimulation would be less painful. PATIENTS AND METHODS: Monocentric prospective study, with 107 sessions of lower limb injections. Two groups of children were compared: localization by ultrasound only (60 children), detection by stimulation only or by stimulation combined with ultrasound (47 children)...
December 2014: Annals of Physical and Rehabilitation Medicine
C Dariane, M Peycelon, P Lallemant, V Forin, G Audry
INTRODUCTION: The urological management of urinary incontinence in neurogenic bladder due to spinal cord lesions in children is intended to achieve social continence while preserving the upper urinary tract, combining clean intermittent catheterization with anticholinergic agents. The objective of this study was to report the results on continence of endoscopic management of bladder and/or sphincter of children with failure or intolerance to first intention therapy. PATIENTS AND METHODS: Of the 364 children followed for neurologic bladder in our institution, 22 required endoscopic management between 2000 and 2012...
January 2014: Progrès en Urologie
Brandon R Macias, Per Aspenberg, Fredrik Agholme
The Sost gene encodes Sclerostin, an inhibitor of Wnt-signaling, generally considered a main response gene to mechanical loading in bone. Several papers describe that unloading leads to upregulation of Sost, which in turn may lead to loss of bone. These studies were based on whole bone homogenates or cortical bone. By serendipity, we noted an opposite response to unloading in the proximal rat tibia. Therefore, we hypothesized that Sost-expression in response to changes in mechanical load is bone site specific...
April 2013: Bone
Krzysztof Czupryna, Janusz Nowotny
BACKGROUND: Physiological human gait is characterized by tree-dimensional pelvis movements, which make that gait is smooth and does not require excessive energy expenditure. In children with cerebral palsy determinants of the pelvis may be affected, mainly due to pathological afferent synergisms. Therefore many specialists is looking for ways to improve this situation. The aim of this study was to verify whether the use of botulinium toxin or inhibitive casts affects the kinematic parameters of the pelvis during the gait of children with hemiparetic form of cerebral palsy...
July 2012: Ortopedia, Traumatologia, Rehabilitacja
Azize Esra Gürsoy, Gülsen Babacan Yildiz, Adam Mehmet Gülhan, Mehmet Kolukisa
A 79-year-old female presented with five months history of progressive involuntary twitching movement on left face. Brain MR imaging revealed a heterogeneous T2 hyperintense lesion at left cerebellopontine angle. CT angiography showed a partially thrombosed saccular aneurysm of left PICA (posterior inferior cerebellar artery). The patient was treated with Botulinum toxin type A and almost total relief of symptoms was noticed during one month followup. Botulinium toxin injection is an effective symptomatic treatment option in nonsurgical secondary hemifacial spasm (HFS) cases...
2012: Case Reports in Neurological Medicine
B Môle
We use the term "scratched face" to define a face which has been streaked by deep wrinkles stretching from the orbital frame up to the temples and neck. Although the origin of these wrinkles seems to be the mime muscle effect; it may also be linked to the presence of Acetylcholine skin receptors in the superficial skin. This would certainly explain the reason for the presence of these wrinkles far from the muscle areas. We can therefore offer very superficial and targeted injections of diluted botulinium Toxin A...
June 2012: Annales de Chirurgie Plastique et Esthétique
David Grabli, Marie Vidailhet
Dystonias encompass a wide range of movement disorders characterized mainly by abnormal postures or movements. Because of this semiological and etiological heterogeneity, robust clinical trials are rare. Specific etiological treatments are available for only a few forms (e.g. Wilson's disease and dopa-responsive dystonia), which places the emphasis on symptomatic treatment. This is based on the combinations of three complementary approaches: drug therapy (anticholinergics, tetrabenazine and benzodiazepines are first-line drugs, but many others have been tested in small clinical trials), botulinium toxin injections in case of focal dystonia or focal targets in patients with more widespread dystonia, and physiotherapy...
April 2011: Bulletin de L'Académie Nationale de Médecine
N Barry Delongchamps, G Robert, A Descazeaud, J-N Cornu, A R Azzouzi, O Haillot, M Devonec, M Fourmarier, C Ballereau, B Lukacs, O Dumonceau, C Saussine, A de la Taille et al.
PURPOSE: To perform an update on mini-invasive surgical treatment of benign prostatic hyperplasia (BPH) by thermotherapy and other emerging techniques. METHOD: A systematic review of literature was performed in Pubmed database for the period running from 1980 to 2011. The level of evidence of each report was evaluated, and only recent publications of high level of evidence were included. RESULTS AND CONCLUSIONS: Monopolar transurethral resection of the prostate (TURP) and open prostatectomy remain the gold standards...
February 2012: Progrès en Urologie
S G Abbasova, N V Ruddenko, A Iu Gorokhovatskiĭ, M V Kapralova, I D Vinogradova, Iu V Vertiev, V A Nesmeianov, E V Grishin
Mouse monoclonal antibodies against the most acutely toxic substances, botulinum neurotoxins (BoNTs) of types A, B, E, and F, was generated and characterized, that recognize their respective toxins in natural toxin complex. Based on these antibodies, we developed sandwich-ELISA for quantitative detection of these toxins. For each respective toxin the detection limit of the assay was: BoNT/A - 0.4 ng/ml, BoNT/B - 0.5 ng/ml; BoNT/E - 0.1 ng/ml; and for BoNT/F - 2.4 ng/ml. The developed assays permitted quantitative identification of the BoNTs in canned meat and vegetables...
May 2011: Bioorganicheskaia Khimiia
G Pancucci, P Miranda-Lloret, M E Plaza-Ramírez, A López-González, V Rovira-Lillo, A Beltrán-Giner
Spondylotic cervical mielopathy is a common complication in young patients with Cerebral Child Palsy with an important dystonic and athetoid component. Its surgical treatment is a challenge, due to elevate incidence of early faliure of the arthrodesis, both in anterior and posterior approaches. We report an historical review about the treatment of cervical mielopathy in this subgroup of patients and a clinical case in which we decided to realize decompression and arthtrodesis by a combined anterior and posterior approach, with lateral-mass screw placement, using botulinium toxin injections in the postoperative period, achieving a good clinical outcome...
June 2011: Neurocirugía
André P Boezaart, Allison Haller, Sarah Laduzenski, Veerandra B Koyyalamudi, Barys Ihnatsenka, Thomas Wright
Neurogenic thoracic outlet syndrome (NTOS) is an oft-overlooked and obscure cause of shoulder pain, which regularly presents to the office of shoulder surgeons and pain specialist. With this paper we present an otherwise healthy young female patient with typical NTOS. She first received repeated conservative treatments with 60 units of botulinium toxin injected into the anterior scalene muscle at three-month intervals, which providing excellent results of symptom-free periods. Later a trans-axillary first rib resection provided semi-permanent relief...
April 2010: International Journal of Shoulder Surgery
Aasef G Shaikh, Stephen Reich, David S Zee
BACKGROUND: A 60 year-old woman with multiple sclerosis (MS) and chronic hearing loss presented with head tremor and vestibular hypofunction, the combination of which can produce oscillopsia--a visual sensation that steady objects in the visual field are oscillating. This case highlights the fact that in patients with pseudonystagmus, oscillopsia is attributable to the association of head tremor and vestibular hypofunction. INVESTIGATIONS: Eye and head movements were measured simultaneously with the search coil technique...
September 2010: Nature Reviews. Neurology
Antonio Gracco, Stephen Tracey
This article reports three cases of Botulinium neurotoxin used to temporarily resolve gingival excess in three female patients who had refused surgical treatment for this condition.
2010: Progress in Orthodontics
S Chabrier, A Roubertie, D Allard, C Bonhomme, V Gautheron
INTRODUCTION: Hemiplegic (or spastic unilateral) cerebral palsy accounts for about 30% of all cases of cerebral palsy. With a population prevalence of 0.6 per 1000 live births, it is the most common type of cerebral palsy among term-born children and the second most common type after diplegia among preterm infants. STATE OF THE ART: Many types of prenatal and perinatal brain injury can lead to congenital hemiplegia and brain MRI is the most useful tool to classify them with accuracy and to provide early prognostic information...
June 2010: Revue Neurologique
S M V Hosseini, H R Foroutan, S Zeraatian, B Sabet
AIMS AND OBJECTIVES: The aim of this study is to find easier way of home care while obviating the colostomy before single stage pull through operation. MATERIALS AND METHODS: From August 2005 to December 2006, eight cases of neonatal Hirschsprung disease were treated. Mean age 4.5 (2-6) day/old with absent anorectal inhibitory reflex, rectosigmiod disease in Barium enema, positive Acetylcholine esterase (Ache) staining, good response to rectal washout. They underwent botulinium toxin injection (5 unit /kg/quadrant) in four quadrant intrasphincteric...
April 2008: Journal of Indian Association of Pediatric Surgeons
Flaminia Frascarelli, Lorenzo Masia, Giuseppe Di Rosa, Maurizio Petrarca, Paolo Cappa, Enrico Castelli
OBJECTIVE: The aim of this pilot study was to examine changes in different aspects of impairment, including spasticity in the upper limbs, of hemiplegic children following botulinum toxin type A intervention. Progress was assessed using standard clinical measurements and a robotic device. DESIGN: Pre-post multiple baseline. SUBJECTS: Six children with hemiplegia. METHODS: Botulinium toxin type A injections were administered into the affected upper limb muscles...
November 2009: Journal of Rehabilitation Medicine
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