Hoang Van Phan, Alexandra Tsitsiklis, Cole P Maguire, Elias K Haddad, Patrice M Becker, Seunghee Kim-Schulze, Brian Lee, Jing Chen, Annmarie Hoch, Harry Pickering, Patrick Van Zalm, Matthew C Altman, Alison D Augustine, Carolyn S Calfee, Steve Bosinger, Charles Cairns, Walter Eckalbar, Leying Guan, Naresh Doni Jayavelu, Steven H Kleinstein, Florian Krammer, Holden T Maecker, Al Ozonoff, Bjoern Peters, Nadine Rouphael, Ruth R Montgomery, Elaine Reed, Joanna Schaenman, Hanno Steen, Ofer Levy, Joann Diray-Arce, Charles R Langelier
Age is a major risk factor for severe coronavirus disease-2019 (COVID-19), yet the mechanisms responsible for this relationship have remained incompletely understood. To address this, we evaluated the impact of aging on host and viral dynamics in a prospective, multicenter cohort of 1,031 patients hospitalized for COVID-19, ranging from 18 to 96 years of age. We performed blood transcriptomics and nasal metatranscriptomics, and measured peripheral blood immune cell populations, inflammatory protein expression, anti-SARS-CoV-2 antibodies, and anti-interferon (IFN) autoantibodies...
February 13, 2024: medRxiv