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Locomotive Syndrome

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https://www.readbyqxmd.com/read/29161707/a-novel-animal-model-simulating-the-beginning-of-combat-exposure
#1
Dongsoo Kim, Chang Yul Kim, Hyojin Koo, Yong Heo, Kicheol Cheon
OBJECTIVE: Predator stress, social defeat stress, and fear conditioning animal models have been applied to investigate combat-related posttraumatic stress disorder (PTSD). However, no animal model psychopharmacological studies have investigated prevention of somatization of increased mental stress and fatigue at the beginning of combat exposure. This study utilized a novel animal model simulating the beginning of combat exposure that aided specification of a set of biomarkers. METHODS: Psychological stress was induced by both inescapable electric foot shock and noise stimuli...
November 22, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29128305/methamphetamine-induced-impulsivity-during-chronic-methamphetamine-treatment-in-rats-effects-of-the-taar-1-agonist-ro5263397
#2
Zhaoxia Xue, Justin N Siemian, Bernard N Johnson, Yanan Zhang, Jun-Xu Li
Impulsivity is an important personality trait associated with several clinical syndromes including drug abuse. While repeated drug exposure is known to increase certain behavioral responses, such as locomotion, to subsequent drug exposure, few studies have examined whether such sensitization develops for impulsive behavior. In the current study we tested the effects of methamphetamine acutely, during the course of, and upon discontinuation of chronic methamphetamine treatment on impulsive behavior in two models, the 5-choice serial reaction time task (5-CSRTT) and the delay-discounting task which measure impulsive action and impulsive choice, respectively...
November 8, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29115022/self-care-agency-lifestyle-and-physical-condition-predict-future-frailty-in-community-dwelling-older-people
#3
Chika Tanimura, Hiromi Matsumoto, Yasuko Tokushima, Junko Yoshimura, Shinji Tanishima, Hiroshi Hagino
The purpose of this 2 year longitudinal study was to identify the relationship between self-care agency, lifestyle, physical condition, and frailty among community-dwelling older people in a rural area of Japan. The participants were 133 older individuals aged 65 years or above. Data collection was conducted via face-to-face interviews using self-administered questionnaires. Background information, such as age, sex, current employment status, family structure, medication use, comorbidities, and knee and lower back pain, were assessed...
November 8, 2017: Nursing & Health Sciences
https://www.readbyqxmd.com/read/29100824/the-25-question-geriatric-locomotive-function-scale-predicts-the-risk-of-recurrent-falls-in-postoperative-patients-with-cervical-myelopathy
#4
Atsushi Kimura, Katsushi Takeshita, Hirokazu Inoue, Atsushi Seichi, Yosuke Kawasaki, Toshitaka Yoshii, Hiroyuki Inose, Takeo Furuya, Kazuhiro Takeuchi, Shunji Matsunaga, Shoji Seki, Mikito Tsushima, Shiro Imagama, Masao Koda, Masashi Yamazaki, Kanji Mori, Hirosuke Nishimura, Kenji Endo, Kei Yamada, Kimiaki Sato, Atsushi Okawa
BACKGROUND: Fall-induced injuries represent a major public health concern for older individuals. The relationship between risk of falling and the severity of locomotive syndrome (LS) remains largely unknown. METHODS: We conducted a retrospective analysis of patients who had undergone surgery from January 2012 to December 2013 and completed at least 1 year of follow-up at 12 participating institutes. Patients completed a questionnaire survey regarding their fall experience during a routine postoperative follow-up...
October 31, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29093169/age-and-speed-dependent-modulation-of-locomotor-gaits-in-dscam-2j-mutant-mice
#5
Louise Thiry, Maxime Lemieux, Frederic Bretzner
Locomotor gaits depend on the interplay between distributed spinal neural networks termed central pattern generators generating rhythmic and coordinated movements, primary afferents and descending supraspinal inputs. Recent studies demonstrated that the mouse display a rich repertoire of locomotor gaits. Changes in locomotor gaits occur in mutant mice lacking particular neurons or molecular signaling pathways implicated in the normal establishment of these neural networks Given the role of the Down Syndrome Cell Adherence Molecule (DSCAM) to the formation and maintenance of spinal interneuronal circuits and sensorimotor integration, we have investigated its functional contribution to locomotor gaits over a wide range of locomotor speeds using freely walking mice...
November 1, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29060496/freezing-of-gait-detection-using-temporal-spatial-and-physiological-features-with-a-support-vector-machine-classifier
#6
Parisa Tahafchi, Rene Molina, Jaimie A Roper, Kristen Sowalsky, Chris J Hass, Aysegul Gunduz, Michael S Okun, Jack W Judy
Freezing-of-Gait (FoG) is a syndrome of Parkinson's disease defined by episodes when patients show a complete inability to take a step or continue with their locomotion. In order to develop closed-loop therapeutic strategies, including deep brain stimulation, a reliable means of detecting freezing episodes is required. By using wearable accelerometers, freezing episodes can be detected with energy-based algorithms when the ratio of the energy in the freeze band (3 to 8 Hz) to that of the locomotion band (0...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29047351/lifestyle-factors-are-significantly-associated-with-the-locomotive-syndrome-a-cross-sectional-study
#7
Manabu Akahane, Shingo Yoshihara, Akie Maeyashiki, Yasuhito Tanaka, Tomoaki Imamura
BACKGROUND: The Japanese Orthopedic Association first proposed the concept of "locomotive syndrome" in 2007. It refers to circumstances in which elderly people need nursing care services or are at high risk of requiring such services within a short time. Recently, the public health burden of providing nursing care for elderly individuals has increased. Therefore, locomotive syndrome, and the means of preventing it, are a major public health focus in Japan. The purpose of this study was to investigate the relationships of lifestyle factors, such as smoking, alcohol consumption, sleep duration, and dental health, with locomotive syndrome...
October 18, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28979107/cognitive-impairment-associated-with-locomotive-syndrome-in-community-dwelling-elderly-women-in-japan
#8
Misa Nakamura, Fumie Tazaki, Kazuki Nomura, Taeko Takano, Masashi Hashimoto, Hiroshi Hashizume, Ichiro Kamei
In our worldwide aging society, elderly people should maintain cognitive and physical function to help avoid health problems. Dementia is a major brain disease among elderly people, and is caused by cognitive impairment. The locomotive syndrome (LS) refers to a condition in which people require healthcare services because of problems associated with locomotion. The purpose of this study was to determine the association between cognitive impairment and LS. Study participants were 142 healthy elderly female volunteers living in a rural area in Japan...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28933238/staged-decrease-of-physical-ability-on-the-locomotive-syndrome-risk-test-is-related-to-neuropathic-pain-nociceptive-pain-shoulder-complaints-and-quality-of-life-in-middle-aged-and-elderly-people-the-utility-of-the-locomotive-syndrome-risk-test
#9
Shiro Imagama, Yukiharu Hasegawa, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Kenyu Ito, Mikito Tsushima, Yoshihiro Nishida, Naoki Ishiguro
OBJECTIVES: A locomotive syndrome (LS) risk test for evaluation of physical ability is recently proposed. The objective of this study is to evaluate the utility of this test by examining physical ability, neuropathic pain, nociceptive pain, shoulder complaints, and quality of life (QOL). METHODS: A prospective cohort study was conducted in 523 subjects (240 males, 283 females; mean age: 63.3 years) at a health checkup. Data collected using visual analog scales (VAS) for shoulder pain, low back pain, sciatica, and knee pain, neuropathic pain, shoulder complaint, body mass index (BMI), osteoporosis, and SF-36 were compared among three LS risk stages...
November 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28932003/quantitative-assessment-of-locomotive-syndrome-by-the-loco-check-questionnaire-in-older-japanese-females
#10
Sachiko Noge, Tatsuo Ohishi, Takuya Yoshida, Hiromichi Kumagai
[Purpose] Locomotive syndrome (LS) is a condition by which older people may require care service because of problems with locomotive organs. This study examined whether the loco-check, a 7-item questionnaire, is useful for quantitatively assessing the severity of LS. [Subjects and Methods] Seventy-one community dwelling Japanese females aged 64-96 years (81.7 ± 8.0 years) participated in this study. The associations of the loco-check with thigh muscle mass measured by X-ray CT, physical performance, nutritional status, and quality of life (QOL) were investigated...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28927741/associations-of-the-step-up-test-and-lower-limb-dysfunction-a-post-hoc-analysis-of-a-prospective-cohort-study
#11
Kiyoshi Kita, Yoshihiro Fukumoto, Yukihide Nishimura, Akihiko Kasuya, Tsuyoshi Asai
BACKGROUND: Step-up ability is considered to be associated with lower limb dysfunction. The objective of this research was to assess the height of the tallest step that could be mounted and to investigate its association with lower limb dysfunction. METHODS: We previously conducted a two-year follow-up prospective cohort study. The study subjects were 119 patients receiving physiotherapy or exercise therapy at an orthopedic surgery clinic. The items evaluated were step-up ability (maximum step height), the timed up and go test, one-leg standing time and the 5-question Geriatric Locomotive Function Scale...
September 18, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28912387/-osteoporosis-liaison-service-and-exercise-regimens-based-on-locomotive-syndrome
#12
Hideaki Ishibashi
The purpose of Osteoporosis Liaison Service(OLS)is primary and secondary prevention of osteoporosis and fragility fracture by multiple medical occupations. Exercise instruction and exercise intervention are important factors in OLS. Exercise has effects of increasing bone density and preventing falls. In OLS, it is also necessary to disseminate knowledge on osteoporosis and fractures to the public. Main measures against locomotive syndrome(LS), meaning weakening of ambulatory ability, are exercise and nutrition, and the LS prevention campaign is thought to lead to prevention of falls...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28812061/behavioral-comorbidities-and-drug-treatments-in-a-zebrafish-scn1lab-model-of-dravet-syndrome
#13
Brian P Grone, Tiange Qu, Scott C Baraban
Loss-of-function mutations in SCN1A cause Dravet syndrome (DS), a catastrophic childhood epilepsy in which patients experience comorbid behavioral conditions, including movement disorders, sleep abnormalities, anxiety, and intellectual disability. To study the functional consequences of voltage-gated sodium channel mutations, we use zebrafish with a loss-of-function mutation in scn1lab, a zebrafish homolog of human SCN1A. Homozygous scn1lab(s552/s552) mutants exhibit early-life seizures, metabolic deficits, and early death...
July 2017: ENeuro
https://www.readbyqxmd.com/read/28747158/characteristics-of-disability-in-activity-of-daily-living-in-elderly-people-associated-with-locomotive-disorders
#14
Tsutomu Iwaya, Tokuhide Doi, Atsushi Seichi, Yuichi Hoshino, Toru Ogata, Masami Akai
BACKGROUND: Ageing is associated with a decline of motor function and ability to perform daily activities. Locomotive disorders are one of the major disorders resulting in adverse health condition in elderly people. Concept of Locomotive syndrome (LoS) was proposed to tackle the problems and prolong healthy life expectancy of people with locomotive disorders. To develop intervention strategy for LoS it is mandatory to investigate impairments, functional disabilities which people with locomotive disorder experience and to examine relationships among these parameters...
July 26, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28745130/longitudinal-association-between-subjective-fatigue-and-future-falls-in-community-dwelling-older-adults-the-locomotive-syndrome-and-health-outcomes-in-the-aizu-cohort-study-lohas
#15
Tsukasa Kamitani, Yosuke Yamamoto, Noriaki Kurita, Shin Yamazaki, Shingo Fukuma, Koji Otani, Miho Sekiguchi, Yoshihiro Onishi, Misa Takegami, Rei Ono, Shinichi Konno, Shinichi Kikuchi, Shunichi Fukuhara
OBJECTIVE: We examined the longitudinal association between the severity of fatigue and falls in community-dwelling older adults. METHOD: Subjective fatigue was assessed using the Short Form 36 Health Survey (SF-36) Vitality subscale and classified into four categories by quartile (mildest, mild, moderate, severe). The main outcome was the incidence of any falls during the 2-year follow-up period. RESULTS: Of the 751 participants, 236 (31...
July 1, 2017: Journal of Aging and Health
https://www.readbyqxmd.com/read/28744031/relationship-of-locomotive-syndrome-with-health-related-quality-of-life-among-patients-with-obstructive-sleep-apnea-syndrome
#16
Hiroaki Kataoka, Nobuyuki Miyatake, Hirohisa Ichikawa, Yukako Arakawa, Yoshihiro Mori
[Purpose] This study aimed to examine the prevalence of locomotive syndrome among patients with obstructive sleep apnea syndrome (OSAS) using the "loco-check" recently developed by the Japanese Orthopedic Association, and to compare health-related quality of life (HRQOL) among patients with and without locomotive syndrome. [Subjects and Methods] This cross-sectional study evaluated 1,195 outpatients with OSAS (1,030 males and 165 females). Locomotive syndrome was evaluated using the Japanese Orthopedic Association's "loco-check"...
July 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28738022/werner-syndrome-a-model-for-sarcopenia-due-to-accelerated-aging
#17
Masaya Yamaga, Minoru Takemoto, Mayumi Shoji, Kenichi Sakamoto, Masashi Yamamoto, Takahiro Ishikawa, Masaya Koshizaka, Yoshiro Maezawa, Kazuki Kobayashi, Koutaro Yokote
Werner syndrome (WS) is a rare inheritable progeroid syndrome caused by a mutation in the WRN gene. Although WS has been described as a characteristic appearance of very slender extremities with a stocky trunk, few studies have investigated the loss of muscle mass, fat mass distribution (body composition), and mobility according to age and sex. Therefore, the aim of this study was to precisely describe the body composition in WS. Nine Japanese patients with WS (four males and five females; mean age 48±8.8 years) were recruited...
July 19, 2017: Aging
https://www.readbyqxmd.com/read/28649109/-aging-and-homeostasis-prevention-and-treatment-of-locomotive-syndrome
#18
Naohisa Miyakoshi
Locomotive syndrome is defined as a condition of reduced mobility due to impairment of the locomotive organs. With the increased aging of society, the demand for the prevention and treatment of locomotive syndrome to improve healthy life expectancy is increasing. Studies have shown that exercise programs including balance training and resistance training are effective in preventing falls. Resistance training also improves walking ability(gait speed)in older adults. In Japan, 'locomotion training' consisting of one-leg standing and squatting exercise is recommended to prevent locomotive syndrome...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28633472/association-between-subjective-sleep-quality-and-future-risk-of-falls-in-older-people-results-from-lohas
#19
Shiho Takada, Yosuke Yamamoto, Sayaka Shimizu, Miho Kimachi, Tatsuyoshi Ikenoue, Shingo Fukuma, Yoshihiro Onishi, Misa Takegami, Shin Yamazaki, Rei Ono, Miho Sekiguchi, Koji Otani, Shin-Ichi Kikuchi, Shin-Ichi Konno, Shunichi Fukuhara
Background: Inadequate sleep is correlated with morbidity and mortality among older adults. However, the longitudinal relationship between subjective sleep quality and risk of falls in the elderly remains to be clarified. Methods: Study participants were from Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS) sites (1071 community-dwelling people ≧65 years of age, mean, 71 years). Subjective sleep quality was measured by the Pittsburgh Sleep Quality Index (PSQI)...
June 17, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28624774/sex-and-genetic-background-influence-superoxide-dismutase-csod-related-phenotypic-variation-in-drosophila-melanogaster
#20
Courtney E Lessel, Tony L Parkes, Joel Dickinson, Thomas J S Merritt
Mutations often have drastically different effects in different genetic backgrounds; understanding a gene's biological function then requires an understanding of its interaction with genetic diversity. The antioxidant enzyme cytosolic copper/zinc superoxide dismutase (cSOD) catalyzes the dismutation of the superoxide radical, a molecule that can induce oxidative stress if its concentration exceeds cellular control. Accordingly, Drosophila melanogaster lacking functional cSOD exhibit a suite of phenotypes including decreased longevity, hypersensitivity to oxidative stress, impaired locomotion, and reduced NADP(H) enzyme activity in males...
August 7, 2017: G3: Genes—Genomes—Genetics
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