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Locomotive Syndrome

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https://www.readbyqxmd.com/read/28933238/staged-decrease-of-physical-ability-on-the-locomotive-syndrome-risk-test-is-related-to-neuropathic-pain-nociceptive-pain-shoulder-complaints-and-quality-of-life-in-middle-aged-and-elderly-people-the-utility-of-the-locomotive-syndrome-risk-test
#1
Shiro Imagama, Yukiharu Hasegawa, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Kenyu Ito, Mikito Tsushima, Yoshihiro Nishida, Naoki Ishiguro
OBJECTIVES: A locomotive syndrome (LS) risk test for evaluation of physical ability is recently proposed. The objective of this study is to evaluate the utility of this test by examining physical ability, neuropathic pain, nociceptive pain, shoulder complaints, and quality of life (QOL). METHODS: A prospective cohort study was conducted in 523 subjects (240 males, 283 females; mean age: 63.3 years) at a health checkup. Data collected using visual analog scales (VAS) for shoulder pain, low back pain, sciatica, and knee pain, neuropathic pain, shoulder complaint, body mass index (BMI), osteoporosis, and SF-36 were compared among three LS risk stages...
February 16, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28932003/quantitative-assessment-of-locomotive-syndrome-by-the-loco-check-questionnaire-in-older-japanese-females
#2
Sachiko Noge, Tatsuo Ohishi, Takuya Yoshida, Hiromichi Kumagai
[Purpose] Locomotive syndrome (LS) is a condition by which older people may require care service because of problems with locomotive organs. This study examined whether the loco-check, a 7-item questionnaire, is useful for quantitatively assessing the severity of LS. [Subjects and Methods] Seventy-one community dwelling Japanese females aged 64-96 years (81.7 ± 8.0 years) participated in this study. The associations of the loco-check with thigh muscle mass measured by X-ray CT, physical performance, nutritional status, and quality of life (QOL) were investigated...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28927741/associations-of-the-step-up-test-and-lower-limb-dysfunction-a-post-hoc-analysis-of-a-prospective-cohort-study
#3
Kiyoshi Kita, Yoshihiro Fukumoto, Yukihide Nishimura, Akihiko Kasuya, Tsuyoshi Asai
BACKGROUND: Step-up ability is considered to be associated with lower limb dysfunction. The objective of this research was to assess the height of the tallest step that could be mounted and to investigate its association with lower limb dysfunction. METHODS: We previously conducted a two-year follow-up prospective cohort study. The study subjects were 119 patients receiving physiotherapy or exercise therapy at an orthopedic surgery clinic. The items evaluated were step-up ability (maximum step height), the timed up and go test, one-leg standing time and the 5-question Geriatric Locomotive Function Scale...
September 16, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28912387/-osteoporosis-liaison-service-and-exercise-regimens-based-on-locomotive-syndrome
#4
Hideaki Ishibashi
The purpose of Osteoporosis Liaison Service(OLS)is primary and secondary prevention of osteoporosis and fragility fracture by multiple medical occupations. Exercise instruction and exercise intervention are important factors in OLS. Exercise has effects of increasing bone density and preventing falls. In OLS, it is also necessary to disseminate knowledge on osteoporosis and fractures to the public. Main measures against locomotive syndrome(LS), meaning weakening of ambulatory ability, are exercise and nutrition, and the LS prevention campaign is thought to lead to prevention of falls...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28812061/behavioral-comorbidities-and-drug-treatments-in-a-zebrafish-scn1lab-model-of-dravet-syndrome
#5
Brian P Grone, Tiange Qu, Scott C Baraban
Loss-of-function mutations in SCN1A cause Dravet syndrome (DS), a catastrophic childhood epilepsy in which patients experience comorbid behavioral conditions, including movement disorders, sleep abnormalities, anxiety, and intellectual disability. To study the functional consequences of voltage-gated sodium channel mutations, we use zebrafish with a loss-of-function mutation in scn1lab, a zebrafish homolog of human SCN1A. Homozygous scn1lab(s552/s552) mutants exhibit early-life seizures, metabolic deficits, and early death...
July 2017: ENeuro
https://www.readbyqxmd.com/read/28747158/characteristics-of-disability-in-activity-of-daily-living-in-elderly-people-associated-with-locomotive-disorders
#6
Tsutomu Iwaya, Tokuhide Doi, Atsushi Seichi, Yuichi Hoshino, Toru Ogata, Masami Akai
BACKGROUND: Ageing is associated with a decline of motor function and ability to perform daily activities. Locomotive disorders are one of the major disorders resulting in adverse health condition in elderly people. Concept of Locomotive syndrome (LoS) was proposed to tackle the problems and prolong healthy life expectancy of people with locomotive disorders. To develop intervention strategy for LoS it is mandatory to investigate impairments, functional disabilities which people with locomotive disorder experience and to examine relationships among these parameters...
July 26, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28745130/longitudinal-association-between-subjective-fatigue-and-future-falls-in-community-dwelling-older-adults-the-locomotive-syndrome-and-health-outcomes-in-the-aizu-cohort-study-lohas
#7
Tsukasa Kamitani, Yosuke Yamamoto, Noriaki Kurita, Shin Yamazaki, Shingo Fukuma, Koji Otani, Miho Sekiguchi, Yoshihiro Onishi, Misa Takegami, Rei Ono, Shinichi Konno, Shinichi Kikuchi, Shunichi Fukuhara
OBJECTIVE: We examined the longitudinal association between the severity of fatigue and falls in community-dwelling older adults. METHOD: Subjective fatigue was assessed using the Short Form 36 Health Survey (SF-36) Vitality subscale and classified into four categories by quartile (mildest, mild, moderate, severe). The main outcome was the incidence of any falls during the 2-year follow-up period. RESULTS: Of the 751 participants, 236 (31...
July 1, 2017: Journal of Aging and Health
https://www.readbyqxmd.com/read/28744031/relationship-of-locomotive-syndrome-with-health-related-quality-of-life-among-patients-with-obstructive-sleep-apnea-syndrome
#8
Hiroaki Kataoka, Nobuyuki Miyatake, Hirohisa Ichikawa, Yukako Arakawa, Yoshihiro Mori
[Purpose] This study aimed to examine the prevalence of locomotive syndrome among patients with obstructive sleep apnea syndrome (OSAS) using the "loco-check" recently developed by the Japanese Orthopedic Association, and to compare health-related quality of life (HRQOL) among patients with and without locomotive syndrome. [Subjects and Methods] This cross-sectional study evaluated 1,195 outpatients with OSAS (1,030 males and 165 females). Locomotive syndrome was evaluated using the Japanese Orthopedic Association's "loco-check"...
July 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28738022/werner-syndrome-a-model-for-sarcopenia-due-to-accelerated-aging
#9
Masaya Yamaga, Minoru Takemoto, Mayumi Shoji, Kenichi Sakamoto, Masashi Yamamoto, Takahiro Ishikawa, Masaya Koshizaka, Yoshiro Maezawa, Kazuki Kobayashi, Koutaro Yokote
Werner syndrome (WS) is a rare inheritable progeroid syndrome caused by a mutation in the WRN gene. Although WS has been described as a characteristic appearance of very slender extremities with a stocky trunk, few studies have investigated the loss of muscle mass, fat mass distribution (body composition), and mobility according to age and sex. Therefore, the aim of this study was to precisely describe the body composition in WS. Nine Japanese patients with WS (four males and five females; mean age 48±8.8 years) were recruited...
July 19, 2017: Aging
https://www.readbyqxmd.com/read/28649109/-aging-and-homeostasis-prevention-and-treatment-of-locomotive-syndrome
#10
Naohisa Miyakoshi
Locomotive syndrome is defined as a condition of reduced mobility due to impairment of the locomotive organs. With the increased aging of society, the demand for the prevention and treatment of locomotive syndrome to improve healthy life expectancy is increasing. Studies have shown that exercise programs including balance training and resistance training are effective in preventing falls. Resistance training also improves walking ability(gait speed)in older adults. In Japan, 'locomotion training' consisting of one-leg standing and squatting exercise is recommended to prevent locomotive syndrome...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28633472/association-between-subjective-sleep-quality-and-future-risk-of-falls-in-older-people-results-from-lohas
#11
Shiho Takada, Yosuke Yamamoto, Sayaka Shimizu, Miho Kimachi, Tatsuyoshi Ikenoue, Shingo Fukuma, Yoshihiro Onishi, Misa Takegami, Shin Yamazaki, Rei Ono, Miho Sekiguchi, Koji Otani, Shin-Ichi Kikuchi, Shin-Ichi Konno, Shunichi Fukuhara
Background: Inadequate sleep is correlated with morbidity and mortality among older adults. However, the longitudinal relationship between subjective sleep quality and risk of falls in the elderly remains to be clarified. Methods: Study participants were from Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS) sites (1071 community-dwelling people ≧65 years of age, mean, 71 years). Subjective sleep quality was measured by the Pittsburgh Sleep Quality Index (PSQI)...
June 17, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28624774/sex-and-genetic-background-influence-superoxide-dismutase-csod-related-phenotypic-variation-in-drosophila-melanogaster
#12
Courtney E Lessel, Tony L Parkes, Joel Dickinson, Thomas J S Merritt
Mutations often have drastically different effects in different genetic backgrounds; understanding a gene's biological function then requires an understanding of its interaction with genetic diversity. The antioxidant enzyme cytosolic copper/zinc superoxide dismutase (cSOD) catalyzes the dismutation of the superoxide radical, a molecule that can induce oxidative stress if its concentration exceeds cellular control. Accordingly, Drosophila melanogaster lacking functional cSOD exhibit a suite of phenotypes including decreased longevity, hypersensitivity to oxidative stress, impaired locomotion, and reduced NADP(H) enzyme activity in males...
August 7, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28612640/do-exercise-habits-during-middle-age-affect-locomotive-syndrome-in-old-age
#13
Akinobu Nishimura, Naoya Ito, Kunihiro Asanuma, Koji Akeda, Toru Ogura, Akihiro Sudo
OBJECTIVES: Locomotive syndrome (LS) encompasses conditions that may lead to the need for nursing services. We aimed to quantify the association between exercise habits during youth or the middle-age years and both physical function and the presence of LS in Japanese elderly people. METHODS: We examined 460 participants of the eighth, ninth, and tenth iterations of the Miyagawa study. Participants were divided into an LS group and a no-LS group according to their scores on the 25-question Geriatric Locomotive Function Scale...
June 14, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28605723/a-combined-cognitive-and-gait-quantification-to-identify-normal-pressure-hydrocephalus-from-its-mimics-the-geneva-s-protocol
#14
Gilles Allali, Magali Laidet, Stéphane Armand, Shahan Momjian, Bruno Marques, Arnaud Saj, Frédéric Assal
OBJECTIVES: Idiopathic normal pressure hydrocephalus (iNPH) is very prevalent in aging, underdiagnosed, and represents a rare cause of reversible neurological condition. The clinical triad of iNPH - gait, cognitive and urinary symptoms - and its neuroradiological features (i.e. ventriculomegaly) are not specific and found a various neurodegenerative and/or vascular conditions. We present our iNPH standardized protocol at the Geneva University Hospitals involving a multispecialty team of behavioral neurologists, neurosurgeons, neuropsychologists, engineers, and physical therapists...
September 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28586744/protective-effects-of-green-tea-on-olanzapine-induced-metabolic-syndrome-in-rats
#15
Bibi Marjan Razavi, Fariba Lookian, Hossein Hosseinzadeh
Atypical antipsychotics particularly olanzapine are associated with obesity and serious metabolic disturbances. As green tea (Camellia sinensis) is generally associated with beneficial effects on obesity and other metabolic disturbances, this study was undertaken to evaluate the effect of green tea aqueous extract (GTAE) on olanzapine induced weight gain and metabolic abnormalities in rats. Male Wistar rats were divided into eight groups: control, olanzapine (5mg/kg/day, IP.), GTAE (25, 50 and 100mg/kg/day, IP...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28584117/histamine-modulation-of-the-basal-ganglia-circuitry-in-the-development-of-pathological-grooming
#16
Maximiliano Rapanelli, Luciana Frick, Haruhiko Bito, Christopher Pittenger
Aberrant histaminergic function has been proposed as a cause of tic disorders. A rare mutation in the enzyme that produces histamine (HA), histidine decarboxylase (HDC), has been identified in patients with Tourette syndrome (TS). Hdc knockout mice exhibit repetitive behavioral pathology and neurochemical characteristics of TS, establishing them as a plausible model of tic pathophysiology. Where, when, and how HA deficiency produces these effects has remained unclear: whether the contribution of HA deficiency to pathogenesis is acute or developmental, and where in the brain the relevant consequences of HA deficiency occur...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28517243/sarcopenia-is-a-risk-factor-for-falling-in-independently-living-japanese-older-adults-a-2-year-prospective-cohort-study-of-the-gaina-study
#17
Hiromi Matsumoto, Chika Tanimura, Shinji Tanishima, Mari Osaki, Hisashi Noma, Hiroshi Hagino
AIM: The purpose of the present study was to investigate whether sarcopenia was associated with future falls in the general Japanese older population. METHODS: This study was a 2-year prospective observational study. Participants were recruited from individuals who had an annual town-sponsored medical check-up and had not received nursing care. The inclusion criteria for participants in our study were: (i) agreement to participate; (ii) living independently; and (iii) the ability to walk to where the survey was carried out and to provide self-reported data...
May 18, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28488382/neuron-specific-knockdown-of-the-drosophila-fat-induces-reduction-of-life-span-deficient-locomotive-ability-shortening-of-motoneuron-terminal-branches-and-defects-in-axonal-targeting
#18
Aya Nakamura, Ryo Tanaka, Kazushige Morishita, Hideki Yoshida, Yujiro Higuchi, Hiroshi Takashima, Masamitsu Yamaguchi
Mutations in FAT4 gene, one of the human FAT family genes, have been identified in Van Maldergem syndrome (VMS) and Hennekam lymphangiectasia-lymphedema syndrome (HS). The FAT4 gene encodes a large protein with extracellular cadherin repeats, EGF-like domains and Laminin G-like domains. FAT4 plays a role in tumor suppression and planar cell polarity. Drosophila contains a human FAT4 homologue, fat. Drosophila fat has been mainly studied with Drosophila eye and wing systems. Here, we specially knocked down Drosophila fat in nerve system...
May 9, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28479917/the-relationship-between-locomotive-syndrome-and-depression-in-community-dwelling-elderly-people
#19
Misa Nakamura, Hiroshi Hashizume, Sachiko Nomura, Ryohei Kono, Hirotoshi Utsunomiya
Locomotive syndrome (LS) is a concept that refers to the condition of people requiring healthcare services because of problems associated with locomotion. Depression is a major psychiatric disease among the elderly, in addition to dementia. The purpose of this study was to determine the association between LS and depression. The study participants were 224 healthy elderly volunteers living in a rural area in Japan. LS was defined as scores ≥ 16 on the 25-question Geriatric Locomotive Function Scale (GLFS-25)...
2017: Current Gerontology and Geriatrics Research
https://www.readbyqxmd.com/read/28465421/hyperactive-locomotion-in-a-drosophila-model-is-a-functional-readout-for-the-synaptic-abnormalities-underlying-fragile-x-syndrome
#20
Risa Kashima, Patrick L Redmond, Prajakta Ghatpande, Sougata Roy, Thomas B Kornberg, Thomas Hanke, Stefan Knapp, Giorgio Lagna, Akiko Hata
Fragile X syndrome (FXS) is the most common cause of heritable intellectual disability and autism and affects ~1 in 4000 males and 1 in 8000 females. The discovery of effective treatments for FXS has been hampered by the lack of effective animal models and phenotypic readouts for drug screening. FXS ensues from the epigenetic silencing or loss-of-function mutation of the fragile X mental retardation 1 (FMR1) gene, which encodes an RNA binding protein that associates with and represses the translation of target mRNAs...
May 2, 2017: Science Signaling
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