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Locomotive Syndrome

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https://www.readbyqxmd.com/read/29757962/the-relationship-between-shoe-fitting-and-foot-health-of-persons-with-down-syndrome-a-case-control-study
#1
César Calvo-Lobo, Ana Ramos García, Marta Elena Losa Iglesias, Daniel López-López, David Rodríguez-Sanz, Carlos Romero-Morales, Ricardo Becerro-de-Bengoa-Vallejo
Background : Down syndrome is the most common chromosomal abnormality and a cause of intellectual disability. It is also associated with orthopaedic and musculoskeletal problems of the locomotive apparatus, especially of the feet. These problems are believed to have a harmful effect on health, social functioning, and mobility. In addition, these persons generally don't have access to podiatric health services, even when their foot problems are well known, because of limited access to healthcare facilities. The goal of our research was to evaluate and compare the foot health status of study participants with and without Down syndrome and to determine whether inadequate footwear is being used with normalized reference values...
May 14, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29750024/locomotive-syndrome-clinical-perspectives
#2
Tatsunori Ikemoto, Young-Chang Arai
The deterioration of locomotive components, which comprise bones, joints, and intervertebral discs, and muscles and nerves, can lead to symptoms such as pain, limitations in the range of joint mobility, malalignment, impaired balance, and difficulty walking. Locomotive syndrome (LoS) was proposed by the Japanese Orthopedic Association in 2007 as a concept for people who are at a high risk of developing a musculoskeletal ambulation disability attributed to locomotor organs. Although many international articles related to LoS have been published, an international consensus of this concept seems to be lacking...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29739985/apple-procyanidins-promote-mitochondrial-biogenesis-and-proteoglycan-biosynthesis-in-chondrocytes
#3
Isao Masuda, Masato Koike, Shohei Nakashima, Yu Mizutani, Yusuke Ozawa, Kenji Watanabe, Yoko Sawada, Hiroshi Sugiyama, Atsushi Sugimoto, Hidetoshi Nojiri, Koichi Sashihara, Koutaro Yokote, Takahiko Shimizu
Apples are well known to have various benefits for the human body. Procyanidins are a class of polyphenols found in apples that have demonstrated effects on the circulatory system and skeletal organs. Osteoarthritis (OA) is a locomotive syndrome that is histologically characterized by cartilage degeneration associated with the impairment of proteoglycan homeostasis in chondrocytes. However, no useful therapy for cartilage degeneration has been developed to date. In the present study, we detected beneficial effects of apple polyphenols or their procyanidins on cartilage homeostasis...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29706699/evaluation-of-left-right-difference-of-impulse-in-impact-forces-at-stance-phase-comparison-of-measurements-on-flat-land-and-stairs
#4
Hiroshi Tasato, Noriyuki Kida
[Purpose] The purpose of this study was to investigate the measurement method and parameters to simply evaluate the condition of the knee that are necessary for preventing locomotive syndrome as advocated by the Japan Orthopedic Association. [Subjects and Methods] The subjects installed acceleration sensors in lateral condyles of the tibia and measured acceleration and load under the conditions of walking on a flat ground and walking using stairs; the difference between the impulse of impact forces (acceleration × load) of the two knees was defined as a simple evaluation parameter...
April 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29705177/the-impact-of-exercise-and-vitamin-d-supplementation-on-physical-function-in-community-dwelling-elderly-individuals-a-randomized-trial
#5
Kana Aoki, Mayumi Sakuma, Naoto Endo
BACKGROUND: We investigated the impact of exercise and vitamin D supplementation on physical function and locomotor dysfunction in community-dwelling elderly individuals. METHODS: In total, 148 community-dwelling elderly individuals (aged ≥60 years) who were not taking osteoporosis medications participated in a 24-week intervention. The participants were randomly divided into an exercise group, vitamin D group, and exercise and vitamin D group. The participants and outcome-assessing staff were not blinded to group assignment...
April 25, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29703571/-complications-after-bariatric-surgery
#6
Regis Souche, Audrey de Jong, Claire Nomine-Criqui, Marius Nedelcu, Laurent Brunaud, David Nocca
Bariatric surgery became consensual after the NIH consensus of 1991 and the appearance of laparoscopic approach. This type of operation has a functional role (improvement of quality of life, locomotion and digestive symptoms as gastro-esophageal reflux disease), a prevention role (increase in life expectancy, reduction of risk of cancer and cardiovascular disease) and a curative role (remission of diabetes mellitus, obstructive sleep apnea syndrome and arterial hypertension). The laparoscopic approach for bariatric surgery led to a major reduction of postoperative morbi-mortality...
April 24, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29699495/association-between-the-gait-pattern-characteristics-of-older-people-and-their-two-step-test-scores
#7
Yoshiyuki Kobayashi, Toru Ogata
BACKGROUND: The Two-Step test is one of three official tests authorized by the Japanese Orthopedic Association to evaluate the risk of locomotive syndrome (a condition of reduced mobility caused by an impairment of the locomotive organs). It has been reported that the Two-Step test score has a good correlation with one's walking ability; however, its association with the gait pattern of older people during normal walking is still unknown. Therefore, this study aims to clarify the associations between the gait patterns of older people observed during normal walking and their Two-Step test scores...
April 27, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29694263/the-decrease-in-phase-angle-measured-by-bioelectrical-impedance-analysis-reflects-the-increased-locomotive-syndrome-risk-in-community-dwelling-people-the-yakumo-study
#8
Satoshi Tanaka, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Taisuke Seki, Takashi Hamada, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Masaaki Machino, Kyotaro Ota, Naoki Ishiguro, Yukiharu Hasegawa, Shiro Imagama
OBJECTIVES: The locomotive syndrome (LS) risk test has recently been advocated for the evaluation of physical ability. Phase angle measurement by bioelectrical impedance analysis (BIA) is an indicator of cellular health and muscle mass. We aimed to investigate how muscle mass and phase angle are related to LS risk stage. METHODS: A prospective cohort study was conducted in 311 patients who were undergoing a health checkup. All participants performed the two-step test, stand-up test, and 25-question geriatric locomotive function scale components of the LS risk test...
April 25, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29689064/association-between-vision-specific-quality-of-life-and-falls-in-community-dwelling-older-adults-lohas
#9
Kakuya Niihata, Shingo Fukuma, Yoshimune Hiratsuka, Koichi Ono, Masakazu Yamada, Miho Sekiguchi, Koji Otani, Shinichi Kikuchi, Shinichi Konno, Shunichi Fukuhara
BACKGROUND: Falls and fall-related fractures are a major public health problem among the older adults. Although objective measures of poor vision have been reported to be associated with falls, the association of self-reported visual function and vision-specific quality of life (QOL) with falls has been inconsistent across several studies. We investigated the association of self-reported visual function and vision specific QOL with falls in community-dwelling older adults. METHODS: We conducted a cross-sectional analysis using the baseline data from participants of the Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS), which is an ongoing population-based cohort study to evaluate the association of physical dysfunction with the clinical outcomes in community-dwelling people...
2018: PloS One
https://www.readbyqxmd.com/read/29652197/relationship-between-locomotive-syndrome-and-body-composition-among-community-dwelling-middle-age-and-elderly-individuals-in-japan-the-yakumo-study
#10
Satoshi Tanaka, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Taisuke Seki, Koji Suzuki, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Masaaki Machino, Kyotaro Ota, Naoki Ishiguro, Yukiharu Hasegawa, Shiro Imagama
OBJECTIVES: Locomotive syndrome (LS) is a condition requiring nursing care for musculoskeletal disorders. Our aim was to evaluate the correlation between body composition, measured by bioelectrical impedance analysis (BIA), and LS, measured using the 25-question Geriatric Locomotive Functional Scale (GLFS-25). METHODS: We enrolled 286 individuals who were undergoing regular health follow-up. All individuals completed the GLFS-25, body composition analysis by BIA, and five physical performance tests related to LS: Timed up-and-go test, 10-m gait time, maximum stride length, back strength, and grip strength...
April 13, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29604258/novel-drosophila-model-for-mitochondrial-diseases-by-targeting-of-a-solute-carrier-protein-slc25a46
#11
Kojiro Suda, Ibuki Ueoka, Yumiko Azuma, Yuuka Muraoka, Hideki Yoshida, Masamitsu Yamaguchi
Mutations in SLC25A46 gene have been identified in mitochondrial diseases that are sometimes classified as Charcot-Marie-Tooth disease type 2, optic atrophy and Leigh syndrome. Human SLC25A46 functions as a transporter across the outer mitochondrial membrane. However, it is still unknown how the neurodegeneration occurring in these diseases relates to the loss of SLC25A46 function. Drosophila has CG5755 (dSLC25A46) as a single human SLC25A46 homolog. Here we established pan-neuron specific dSLC25A46 knockdown flies, and examined their phenotypes...
March 28, 2018: Brain Research
https://www.readbyqxmd.com/read/29575947/the-utility-of-25-question-geriatric-locomotive-function-scale-for-evaluating-functional-ability-and-disease-activity-in-japanese-rheumatoid-arthritis-patients-a-cross-sectional-study-using-ninja-database
#12
Naohiro Izawa, Jun Hirose, Tomoko Fujii, Hiroyuki Oka, Kosuke Uehara, Masashi Naito, Takumi Matsumoto, Sakae Tanaka, Shigeto Tohma
OBJECTIVES: To investigate the distribution of 25-question Geriatric Locomotive Function Scale (GLFS-25) scores in Japanese rheumatoid arthritis (RA) patients and evaluate relationships with clinical variables. METHODS: Among 15,115 patients registered in the NinJa database for fiscal year 2015, 1,710 with complete GLFS-25 and Disease Activity Score-28 (DAS28) data were analyzed. Correlations between GLFS-25 score and clinical variables were assessed by Spearman coefficients...
March 26, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29547474/exfoliation-syndrome-a-disease-of-autophagy-and-loxl1-proteopathy
#13
Audrey M Bernstein, Robert Ritch, J Mario Wolosin
Exfoliation syndrome (XFS) is an age-related disease involving the deposition of aggregated fibrillar material (XFM) at extracellular matrices in tissues that synthesize elastic fibers. Its main morbidity is in the eye, where XFM accumulations form on the surface of the ciliary body, iris and lens. Exfoliation glaucoma (XFG) occurs in a high proportion of persons with XFS and can be a rapidly progressing disease. Worldwide, XFG accounts for about 25% of open-angle glaucoma cases. XFS and XFG show a sharp age-dependence, similarly to the many age-related diseases classified as aggregopathies...
March 15, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29535995/assessing-brain-muscle-connectivity-in-human-locomotion-through-mobile-brain-body-imaging-opportunities-pitfalls-and-future-directions
#14
Federico Gennaro, Eling D de Bruin
Assessment of the cortical role during bipedalism has been a methodological challenge. While surface electroencephalography (EEG) is capable of non-invasively measuring cortical activity during human locomotion, it is associated with movement artifacts obscuring cerebral sources of activity. Recently, statistical methods based on blind source separation revealed potential for resolving this issue, by segregating non-cerebral/artifactual from cerebral sources of activity. This step marked a new opportunity for the investigation of the brains' role while moving and was tagged mobile brain/body imaging (MoBI)...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29529893/the-impact-of-musculoskeletal-diseases-on-the-presence-of-locomotive-syndrome
#15
Manabu Akahane, Akie Maeyashiki, Yasuhito Tanaka, Tomoaki Imamura
OBJECTIVES: We assessed the impact of musculoskeletal diseases, depressive mental state, and hypertension on locomotive syndrome, a condition of reduced mobility requiring nursing care. Since locomotive syndrome is a major public health issue that needs attention, its relationship with functional inconvenience in performing daily activities was also investigated. METHODS: We conducted a cross-sectional study using an Internet panel survey, comprising 747 persons aged 30-90 years...
April 9, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29442538/serum-cystatin-c-level-is-associated-with-locomotive-syndrome-risk-and-can-be-an-early-predictor-in-community-living-people-the-yakumo-study
#16
Satoshi Tanaka, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Masaaki Machino, Kyotaro Ota, Taisuke Seki, Koji Suzuki, Yoshihiro Nishida, Naoki Ishiguro, Yukiharu Hasegawa, Shiro Imagama
OBJECTIVES: The locomotive syndrome (LS) risk has been recently proposed as a criterion for evaluating physical ability. Serum cystatin C level is an early renal function marker and a cardiovascular disease predictor. This study aimed to evaluate the relationship between serum cystatin C level and LS risk. METHODS: We enrolled 54 participants and conducted the two-step test, stand-up test, 25-question geriatric locomotive function scale, LS risk test, Timed Up and Go test, back muscle strength, grip strength, blood test and serum cystatin C level measurement...
March 2, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29410586/identifying-elderly-people-at-risk-for-cognitive-decline-by-using-the-2-step-test
#17
Kohei Maruya, Hiroaki Fujita, Tomoyuki Arai, Toshiki Hosoi, Kennichi Ogiwara, Shunnichiro Moriyama, Hideaki Ishibashi
[Purpose] The purpose is to verify the effectiveness of the 2-step test in predicting cognitive decline in elderly individuals. [Subjects and Methods] One hundred eighty-two participants aged over 65 years underwent the 2-step test, cognitive function tests and higher level competence testing. Participants were classified as Robust, <1.3, and <1.1 using criteria regarding the locomotive syndrome risk stage for the 2-step test, variables were compared between groups. In addition, ordered logistic analysis was used to analyze cognitive functions as independent variables in the three groups, using the 2-step test results as the dependent variable, with age, gender, etc...
January 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29408090/effects-of-ralfinamide-in-models-of-nerve-injury-and-chemotherapy-induced-neuropathic-pain
#18
Xiaonan Liang, Gang Yu, Ruibin Su
Neuropathic pain is among the most common and difficult-to-treat types of chronic pain and is associated with sodium channel malfunction. The sodium channel blocker ralfinamide has exhibited potent analgesic effects in several preclinical pain models and in patients with mixed neuropathic pain syndromes (Phase II trials), but it failed to ameliorate neuropathic low back pain in Phase III trials. It is unclear whether ralfinamide is effective against neuropathic pain induced by specified etiologies. In the present study, the antinociceptive effects of ralfinamide in neuropathic pain models induced by spared nerve injury and chemotherapy were compared in a gabapentin-controlled manner...
March 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29374303/negative-allosteric-modulation-of-alpha-5-containing-gaba-a-receptors-engenders-antidepressant-like-effects-and-selectively-prevents-age-associated-hyperactivity-in-tau-depositing-mice
#19
Nina Z Xu, Margot Ernst, Marco Treven, Rok Cerne, Mark Wakulchik, Xia Li, Timothy M Jones, Scott D Gleason, Denise Morrow, Jeffrey M Schkeryantz, Md Toufiqur Rahman, Guanguan Li, Michael M Poe, James M Cook, Jeffrey M Witkin
RATIONALE: Associated with frank neuropathology, patients with Alzheimer's disease suffer from a host of neuropsychiatric symptoms that include depression, apathy, agitation, and aggression. Negative allosteric modulators (NAMs) of α5-containing GABAA receptors have been suggested to be a novel target for antidepressant action. We hypothesized that pharmacological modulation of this target would engender increased motivation in stressful environments. METHODS: We utilized electrophysiological recordings from Xenopus oocytes and behavioral measures in mice to address this hypothesis...
April 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29373956/age-independency-of-mobility-decrease-assessed-using-the-locomotive-syndrome-risk-test-in-elderly-with-disability-a-cross-sectional-study
#20
Keiko Yamada, Shingo Muranaga, Tomohiro Shinozaki, Kozo Nakamura, Sakae Tanaka, Toru Ogata
BACKGROUND: Mobility decrease is reportedly age-dependent in community dwelling elderly, and a major factor of disability in the geriatric population. The purpose of this study is to examine whether mobility decrease, as assessed using a set of tests, is similarly age-dependent in elderly adults who already have disability. METHODS: One hundred thirty-five community-dwelling elderly (54 men, 81 women) with disability and 1469 independent community dwellers (1009 men, 460 women) were analyzed...
January 26, 2018: BMC Geriatrics
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