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Locomotive Syndrome

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https://www.readbyqxmd.com/read/28058999/sex-differences-in-quadrupedal-walking-gaits-of-uner-tan-syndrome-cases-healthy-humans-and-nonhuman-primates
#1
Uner Tan
BACKGROUND: Uner Tan syndrome (UTS) cases with habitual quadrupedal locomotion (QL), impaired intelligence, and dysarthric or no speech predominantly use lateral sequence (LS) gait like nonprimates rather than the predominantly diagonal sequence (DS) gait of nonhuman primates. However, these studies neglected possible sex-related differences in these gait types. OBJECTIVES: (1) To assess the possible sex-related gait types in UTS cases, healthy infants and adults with requested QL, and the nonhuman primates...
January 6, 2017: Neurological Research
https://www.readbyqxmd.com/read/28017942/-physical-activity-for-knee-osteoarthritis
#2
Masashi Nagao, Muneaki Ishijima, Haruka Kaneko, Yuji Takazawa, Hiroshi Ikeda, Kazuo Kaneko
Elder populations have been increasing in Japan and estimated 24 million people have knee osteoarthritis(OA). Recently, people have diverse sociological background and demand for participating sports has been growing. People may participate sports to prevent some diseases such as locomotive syndrome. According to the recent studies, excessive high impact sports increase the risk of OA, while daily life exercise decrease the risk. Epidemiological approach demonstrated that reduced knee extension muscle strength increases the risk of OA...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28017940/-the-significance-of-exercises-and-sports-in-the-locomotive-syndrome-prevention
#3
Hideaki Ishibashi
In Japan, the world's fastest aging country, the locomotive syndrome that shows a decrease in the mobility due to dysfunctions of the locomotor organs is a major risk factor of long-term care need in the old age. Exercises and sports habits are well reviewed to lead to the improvement and maintenance of motor function, and exercises are also useful in the prevention of a number of musculoskeletal diseases. In addition, several trials with the exercise intervention indicated improvement in motor function, suggesting exercises could prevent the locomotive syndrome...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28013290/uner-tan-syndrome-caused-by-a-homozygous-tubb2b-mutation-affecting-microtubule-stability
#4
Martin W Breuss, Thai Nguyen, Anjana Srivatsan, Ines Leca, Guoling Tian, Tanja Fritz, Andi H Hansen, Damir Musaev, Jennifer McEvoy-Venneri, Kiely N James, Rasim O Rosti, E Scott, Uner Tan, Richard D Kolodner, Nicholas J Cowan, David A Keays, Joseph G Gleeson
The integrity and dynamic properties of the microtubule cytoskeleton are indispensable for the development of the mammalian brain. Consequently, mutations in the genes that encode the structural component (the α/β-tubulin heterodimer) can give rise to severe, sporadic neurodevelopmental disorders. These are commonly referred to as the tubulinopathies. Here we report the addition of recessive quadrupedalism, also known as Uner Tan syndrome (UTS), to the growing list of diseases caused by tubulin variants. Analysis of a consanguineous UTS family identified a biallelic TUBB2B mutation, resulting in a p...
December 23, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27943574/factors-associated-with-functional-limitations-in-the-daily-living-activities-of-japanese-hip-osteoarthritis-patients
#5
Kyoko Kondo, Seiya Jingushi, Satoko Ohfuji, Muroto Sofue, Moritoshi Itoman, Tadami Matsumoto, Yoshiki Hamada, Hiroyuki Shindo, Yoshio Takatori, Harumoto Yamada, Yuji Yasunaga, Hiroshi Ito, Satoshi Mori, Ichiro Owan, Genji Fujii, Hirotsugu Ohashi, Wakaba Fukushima, Akiko Maeda, Miki Inui, Shinji Takahashi, Yoshio Hirota
AIM: As society ages, there is a vast number of elderly people with locomotive syndrome. In this study, the factors associated with functional limitations in daily living activities evaluated by female hip osteoarthritis (OA) patients were investigated. METHODS: This study was a cross-sectional study. The subjects were 353 female patients who were newly diagnosed with hip OA at an orthopedic clinic with no history of hip joint surgery. Outcome indices were functional limitations in two daily living activities obtained from a questionnaire completed by the patients: (i) standing up (standing from a crouched position) and (ii) stair-climbing (climbing and/or descending stairs)...
December 10, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/27919650/association-between-dysfunction-of-upper-extremity-and-locomotive-syndrome-in-general-population
#6
Tsuyoshi Tajika, Atsushi Yamamoto, Noboru Oya, Chisa Okura, Satoshi Shinagawa, Takanori Kitagawa, Hiroki Kobayashi, Haku Iizuka, Kenji Takagishi
OBJECTIVE: This study investigated the relation between self-assessment of upper extremity function and locomotive syndrome in a general population. METHODS: Using the 25-question Geriatric Locomotive Function (GLFS-25) test, 320 Japanese people (115 men, 205 women, mean age 67.6 years, 40-92 years) were evaluated for locomotive dysfunction. All had completed a self-administered questionnaire including items for sex, weight, height, dominant hand, and the degree of frequency of hand in ADL...
December 2, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27862879/locomotive-syndrome-is-associated-with-large-blood-pressure-variability-in-elderly-hypertensives-the-japan-ambulatory-blood-pressure-prospective-jamp-substudy
#7
Yuki Imaizumi, Kazuo Eguchi, Takeshi Murakami, Tomohiro Saito, Satoshi Hoshide, Kazuomi Kario
Chronic pain, represented by locomotive syndrome (LS), and psychosocial factors are possible factors of blood pressure (BP) variability (BPV). The authors tested the hypothesis that there are links among LS, depression, and BPV. In 85 Japanese elderly hypertensive patients with normal daily activities, the authors performed ambulatory BP monitoring, determined the LS scale (LSS), and administered the Self-Rating Questionnaire for Depression (SRQD). The LSS score but not the SRQD score was associated with the standard deviation (SD) and coefficient of variation (CV) of daytime systolic BP (SBP) and SD of nighttime SBP (all P<...
November 15, 2016: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/27862616/topical-gabapentin-gel-alleviates-allodynia-and-hyperalgesia-in-the-chronic-sciatic-nerve-constriction-injury-neuropathic-pain-model
#8
M Shahid, F Subhan, N Ahmad, G Ali, S Akbar, K Fawad, R D E Sewell
BACKGROUND: Systemic gabapentin is a mainstay treatment for neuropathic pain though there are side-effects. Localized therapy may curtail such side-effects so a topical gabapentin dermal application was examined in the chronic constriction injury (CCI) model of neuropathic pain. METHODS: Partial denervation CCI was achieved by rat sciatic nerve ligation. Gabapentin gel (10% w/w) was applied three times daily on the ipsilateral or contralateral plantar surface of the hind-paw, whereas in a concurrent systemic study, gabapentin was intraperitoneally administered daily (75 mg/kg) for 30 days...
November 8, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27833142/murine-hypothalamic-destruction-with-vascular-cell-apoptosis-subsequent-to-combined-administration-of-human-papilloma-virus-vaccine-and-pertussis-toxin
#9
Satoko Aratani, Hidetoshi Fujita, Yoshiyuki Kuroiwa, Chie Usui, Shumpei Yokota, Ikuro Nakamura, Kusuki Nishioka, Toshihiro Nakajima
Vaccination is the most powerful way to prevent human beings from contracting infectious diseases including viruses. In the case of the human papillomavirus (HPV) vaccine, an unexpectedly novel disease entity, HPV vaccination associated neuro-immunopathetic syndrome (HANS), has been reported and remains to be carefully verified. To elucidate the mechanism of HANS, we applied a strategy similar to the active experimental autoimmune encephalitis (EAE) model - one of the most popular animal models used to induce maximum immunological change in the central nervous system...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27754073/os-18-05-sarcopenia-is-independently-associated-with-arterial-stiffness-in-patients-with-type-2-diabetes
#10
Yuki Imaizumi, Kazuo Eguchi, Toshiki Kaihara, Kumiko Urano, Rieko Shinagawa, Minoru Araki, Koji Inoue, Koichiro Hokao, Yuka Tsujita, Takuya Furusawa, Ryuichiro Kaku, Kazuomi Kario
OBJECTIVE: We tested the hypothesis that sarcopenia, an age-related loss of skeletal muscle mass and function, is associated with arterial stiffness in patients with diabetes (DM). DESIGN AND METHOD: We studied 65 hypertensives in the Real BP study, an observational study of home BP telemonitoring system. As parameters of sarcopenia, we used locomotive syndrome scale, circumference of the wrist, lower leg, and thigh (10 cm above the patella), grip strength, and 6 minute-walk test...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27681283/awareness-and-health-consciousness-regarding-the-national-health-plan-health-japan-21-2nd-edition-among-the-japanese-population-in-2013-and-2014
#11
Kemmyo Sugiyama, Yasutake Tomata, Yukari Takemi, Kazuyo Tsushita, Masakazu Nakamura, Shuji Hashimoto, Motohiko Miyachi, Zentaro Yamagata, Tetsuji Yokoyama, Ichiro Tsuji
Objectives To examine the prevalence of health consciousness regarding "Health Japan 21" (2nd edition) among the Japanese population, we conducted a telephone survey of a sample extracted randomly from the whole nation in 2013 and 2014.Methods We extracted 1800 men and women with 150 persons for each gender and 10-year age group (6 age groups ranging from 20 years to 70 years and older) using Random Digital Dialing sampling. Each participant was asked about 1) recognition of the following items: "Health Japan 21," "healthy life expectancy," "metabolic syndrome (MetS)," "chronic obstructive pulmonary disease (COPD)," "locomotive syndrome," "Active Guide," "WHO Framework Convention on Tobacco Control," and "Smart Life Project" and 2) health consciousness toward the following: "health examination taken within the past one year," "smoking status," and "the amount of vegetables considered desirable to consume per day for health...
2016: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
https://www.readbyqxmd.com/read/27678549/neurobehavioral-effects-of-vigabatrin-and-its-ability-to-induce-dna-damage-in-brain-cells-after-acute-treatment-in-rats
#12
Karen Sousa, Natalia Decker, Thienne Rocha Pires, Débora Kuck Mausolff Papke, Vanessa Rodrigues Coelho, Pricila Pflüger, Patrícia Pereira, Jaqueline Nascimento Picada
RATIONALE: Vigabatrin (VGB) is a drug indicated mostly for the treatment of spasms in childhood and West's syndrome patients. This drug inhibits irreversibly the enzyme GABA-transaminase (GABA-T), increasing GABA concentrations and enhancing GABAergic neurotransmission in the brain, which is known to induce behavioral changes. OBJECTIVES: The aims of this study were to evaluate the effects of VGB in the short-term memory (STM), long-term memory (LTM), motivation, locomotion, and exploratory behavior tests and to detect deleterious or protective effects on DNA in target tissues of the drug...
January 2017: Psychopharmacology
https://www.readbyqxmd.com/read/27677265/locomotive-syndrome-is-associated-with-body-composition-and-cardiometabolic-disorders-in-elderly-japanese-women
#13
Misa Nakamura, Yosuke Kobashi, Hiroshi Hashizume, Hiroyuki Oka, Ryohei Kono, Sachiko Nomura, Akihiro Maeno, Munehito Yoshida, Hirotoshi Utsunomiya
BACKGROUND: A concept referred to as locomotive syndrome (LS) was proposed by the Japanese Orthopaedic Association in order to help identify middle-aged and older adults who may be at high risk of requiring healthcare services because of problems associated with locomotion. Cardiometabolic disorders, including obesity, hypertension, diabetes, and dyslipidemia, have a high prevalence worldwide. The purpose of this study was to determine the associations between LS and both body composition and cardiometabolic disorders...
September 27, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27676759/impact-of-fatigue-on-postural-control-in-quiet-standing-in-fibromyalgia
#14
Jacques Vaillant, Perrine Revillet, Anne-Marie Sevenier, Robert Juvin
OBJECTIVE: Fibromyalgia fatigue was described as an overwhelming feeling of tiredness that is not relieved by sleep or rest and is often not in proportion to the effort realized. In fibromyalgia syndrome (FMS), the fatigue has an important functional impact, often limiting the activities of daily living, can induce a state of deconditioning, and causing disturbance of locomotion, whose reasons are not fully understood. The aims of this study was to evaluate the postural performance in quite standing of FMS patients, and to compare them to a control group, and to assess the influence on the posture of a fatigue induced by a short walk...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676727/subjects-with-fibromyalgia-syndrome-have-a-reduction-of-balance-performance
#15
Jacques Vaillant, Sophie Pissety, Silvia Martinez, Robert Juvin
OBJECTIVE: If subjects with fibromyalgia syndrome (FMS) firstly describe painful and fatigue syndromes, secondly some of them described latent postural disorders or frailty. If decrease of postural performance has been described on osteoarthritis diseases of lower limb, it is unknown on fibromyalgia. The aim of this study was to assess clinical perform on balance and gait of patients with FMS. MATERIAL/PATIENTS AND METHODS: The sample was selected in-patients or in consultation in the rheumatology department and from those patients participating in a programme of rehabilitation...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27648459/mutation-of-orthologous-prickle-genes-causes-a-similar-epilepsy-syndrome-in-flies-and-humans
#16
Salleh N Ehaideb, Elizabeth A Wignall, Junko Kasuya, William H Evans, Atulya Iyengar, Haley L Koerselman, Anthony J Lilienthal, Alexander G Bassuk, Toshihiro Kitamoto, J Robert Manak
OBJECTIVE: Genetically tractable fruit flies have been used for decades to study seizure disorders. However, there is a paucity of data specifically correlating fly and human seizure phenotypes. We have previously shown that mutation of orthologous PRICKLE genes from flies to humans produce seizures. This study aimed to determine whether the prickle-mediated seizure phenotypes in flies closely parallel the epilepsy syndrome found in PRICKLE patients. METHODS: Virtually all fly seizure studies have relied upon characterizing seizures that are evoked...
September 2016: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/27642994/os-18-05-sarcopenia-is-independently-associated-with-arterial-stiffness-in-patients-with-type-2-diabetes
#17
Yuki Imaizumi, Kazuo Eguchi, Toshiki Kaihara, Kumiko Urano, Rieko Shinagawa, Minoru Araki, Koji Inoue, Koichiro Hokao, Yuka Tsujita, Takuya Furusawa, Ryuichiro Kaku, Kazuomi Kario
OBJECTIVE: We tested the hypothesis that sarcopenia, an age-related loss of skeletal muscle mass and function, is associated with arterial stiffness in patients with diabetes (DM). DESIGN AND METHOD: We studied 65 hypertensives in the Real BP study, an observational study of home BP telemonitoring system. As parameters of sarcopenia, we used locomotive syndrome scale, circumference of the wrist, lower leg, and thigh (10 cm above the patella), grip strength, and 6 minute-walk test...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27600888/-uveitis-in-spondyloarthritis-patients-and-its-association-with-hla-b27-histocompatibility-antigen-prospective-study
#18
I Yu Razumova, A A Godzenko, O K Vorob'eva, I A Guseva
AIM: to perform a prospective study of clinical presentation and course of uveitis in spondyloarthritis (SpA) patients as well as its association with the HLA-B27 histocompatibility antigen. MATERIAL AND METHODS: The study included 219 patients with uveitis, all tested for HLA-B27 antigen and various infections (viral, bacterial, and parasitic) as well as examined for locomotive system involvement. RESULTS: The presence of the HLA-B27 antigen was determined in 142 (64...
July 2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27541642/whole-exome-sequencing-of-rett-syndrome-like-patients-reveals-the-mutational-diversity-of-the-clinical-phenotype
#19
Mario Lucariello, Enrique Vidal, Silvia Vidal, Mauricio Saez, Laura Roa, Dori Huertas, Mercè Pineda, Esther Dalfó, Joaquin Dopazo, Paola Jurado, Judith Armstrong, Manel Esteller
Classical Rett syndrome (RTT) is a neurodevelopmental disorder where most of cases carry MECP2 mutations. Atypical RTT variants involve mutations in CDKL5 and FOXG1. However, a subset of RTT patients remains that do not carry any mutation in the described genes. Whole exome sequencing was carried out in a cohort of 21 female probands with clinical features overlapping with those of RTT, but without mutations in the customarily studied genes. Candidates were functionally validated by assessing the appearance of a neurological phenotype in Caenorhabditis elegans upon disruption of the corresponding ortholog gene...
December 2016: Human Genetics
https://www.readbyqxmd.com/read/27538793/epidemiology-of-the-locomotive-syndrome-the-research-on-osteoarthritis-osteoporosis-against-disability-study-2005-2015
#20
Noriko Yoshimura, Shigeyuki Muraki, Kozo Nakamura, Sakae Tanaka
Although locomotive organ disorders are major causes of disability and require support, little information is available regarding their epidemiology. Prevalence and co-existence of locomotive organ disorders including knee osteoarthritis (KOA), lumbar spondylosis (LS), hip osteoarthritis, and osteoporosis have been determined from baseline results of the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study. KOA, LS, and hip osteoarthritis overlap in the population, while KOA and LS co-exist in 42...
January 2017: Modern Rheumatology
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