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Locomotive Syndrome

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https://www.readbyqxmd.com/read/28517243/sarcopenia-is-a-risk-factor-for-falling-in-independently-living-japanese-older-adults-a-2-year-prospective-cohort-study-of-the-gaina-study
#1
Hiromi Matsumoto, Chika Tanimura, Shinji Tanishima, Mari Osaki, Hisashi Noma, Hiroshi Hagino
AIM: The purpose of the present study was to investigate whether sarcopenia was associated with future falls in the general Japanese older population. METHODS: This study was a 2-year prospective observational study. Participants were recruited from individuals who had an annual town-sponsored medical check-up and had not received nursing care. The inclusion criteria for participants in our study were: (i) agreement to participate; (ii) living independently; and (iii) the ability to walk to where the survey was carried out and to provide self-reported data...
May 18, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28488382/neuron-specific-knockdown-of-the-drosophila-fat-induces-reduction-of-life-span-deficient-locomotive-ability-shortening-of-motoneuron-terminal-branches-and-defects-in-axonal-targeting
#2
Aya Nakamura, Ryo Tanaka, Kazushige Morishita, Hideki Yoshida, Yujiro Higuchi, Hiroshi Takashima, Masamitsu Yamaguchi
Mutations in FAT4 gene, one of the human FAT family genes, have been identified in Van Maldergem syndrome (VMS) and Hennekam lymphangiectasia-lymphedema syndrome (HS). The FAT4 gene encodes a large protein with extracellular cadherin repeats, EGF-like domains and Laminin G-like domains. FAT4 plays a role in tumor suppression and planar cell polarity. Drosophila contains a human FAT4 homologue, fat. Drosophila fat has been mainly studied with Drosophila eye and wing systems. Here, we specially knocked down Drosophila fat in nerve system...
May 9, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28479917/the-relationship-between-locomotive-syndrome-and-depression-in-community-dwelling-elderly-people
#3
Misa Nakamura, Hiroshi Hashizume, Sachiko Nomura, Ryohei Kono, Hirotoshi Utsunomiya
Locomotive syndrome (LS) is a concept that refers to the condition of people requiring healthcare services because of problems associated with locomotion. Depression is a major psychiatric disease among the elderly, in addition to dementia. The purpose of this study was to determine the association between LS and depression. The study participants were 224 healthy elderly volunteers living in a rural area in Japan. LS was defined as scores ≥ 16 on the 25-question Geriatric Locomotive Function Scale (GLFS-25)...
2017: Current Gerontology and Geriatrics Research
https://www.readbyqxmd.com/read/28465421/hyperactive-locomotion-in-a-drosophila-model-is-a-functional-readout-for-the-synaptic-abnormalities-underlying-fragile-x-syndrome
#4
Risa Kashima, Patrick L Redmond, Prajakta Ghatpande, Sougata Roy, Thomas B Kornberg, Thomas Hanke, Stefan Knapp, Giorgio Lagna, Akiko Hata
Fragile X syndrome (FXS) is the most common cause of heritable intellectual disability and autism and affects ~1 in 4000 males and 1 in 8000 females. The discovery of effective treatments for FXS has been hampered by the lack of effective animal models and phenotypic readouts for drug screening. FXS ensues from the epigenetic silencing or loss-of-function mutation of the fragile X mental retardation 1 (FMR1) gene, which encodes an RNA binding protein that associates with and represses the translation of target mRNAs...
May 2, 2017: Science Signaling
https://www.readbyqxmd.com/read/28452565/administration-of-wasabia-koreana-ameliorates-irritable-bowel-syndrome-like-symptoms-in-a-zymosan-induced-mouse-model
#5
Bo-Kyung Park, Eunho Chun, Jeong June Choi, Younmin Shin, Young Tak Kho, Seung Hyun Oh, Sun Yeou Kim, Taek Hwan Lee, Tae-Wan Kim, Eunju Shin, Seon-Gil Do, Mirim Jin
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with complex pathophysiology involving the brain-gut axis. To assess the effects of Wasabia koreana (WK) on IBS, we employed a mouse model of colonic zymosan injection presenting with diarrhea-predominant IBS-like symptoms. Oral WK administration significantly diminished stool score, suppressed colon length and weight change, and minimized body weight loss without affecting food intake. In WK-treated mice, the submucosal thickening and epithelial lining of the colon were inhibited and were similar to those of naïve mice...
May 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28439049/-calcium-and-bone-metabolism-across-women-s-life-stages-epidemiology-of-bone-and-joint-disease-in-japanese-women
#6
Shigeyuki Muraki
Bone and joint diseases are severe problems in the elderly;therefore, the development of their treatment or prophylaxis is quite important. Our study shows that the prevalence of osteoporosis and osteoarthritis is very high, and its impact on quality of life is strong. The treatment rate of osteoporosis is less than 10%, and awareness programs for prevention of osteoporosis and osteoarthritis disorders such as locomotive syndrome are needed.
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28303060/evaluation-of-the-association-between-locomotive-syndrome-and-depressive-states-a-cross-sectional-study
#7
Tomohiro Saito, Hideaki Watanabe, Ichiro Kikkawa, Katsushi Takeshita
The Japanese Orthopaedic Association has proposed the term "locomotive syndrome" to designate a condition that places a person at high risk for long-term care. However, in daily clinical practice, even when a diagnosis of locomotive syndrome is made, exercise therapy often cannot be successfully performed in some patients owing to their lack of motivation. We speculated that locomotive syndrome and depressive states co-exist in elderly people. The purpose of this study was to determine the presence or absence of depressive states in older patients aged ≥ 65 years who were diagnosed with locomotive syndrome...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28286203/association-between-manual-loading-and-newly-developed-carpal-tunnel-syndrome-in-subjects-with-physical-disabilities-a-follow-up-study
#8
Yen-Nung Lin, Chun-Chieh Chiu, Shih-Wei Huang, Wen-Yen Hsu, Tsan-Hon Liou, Yi-Wen Chen, Kwang-Hwa Chang
OBJECTIVE: To identify the association between body composition and newly developed carpal tunnel syndrome (CTS) and to search for the best probabilistic cutoff value of associated factors to predict subjects with physical disabilities developing new CTS. DESIGN: Longitudinal. SETTING: University-affiliated medical center. PARTICIPANTS: Subjects with physical disabilities (N=47; mean age ± SD, 42.1±7.7y). INTERVENTIONS: Not applicable...
March 9, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28193688/compulsive-social-behavior-emerges-after-selective-ablation-of-striatal-cholinergic-interneurons
#9
Yanina V Martos, Barbara Y Braz, Juan P Beccaria, M Gustavo Murer, Juan E Belforte
The mechanisms underlying social dysfunction in neuropsychiatric conditions like obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) remain uncertain. Dysfunctions in basal ganglia, including reduced number of striatal cholinergic interneurons (SCIN), have been involved in their pathophysiology. To explore the role of SCIN in relation to perseverative behaviors we characterized a new transgenic mouse model in which inducible ablation of SCIN is achieved with high efficiency in a cell-type and region specific manner...
February 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28137403/locomotive-syndrome-in-the-elderly-translation-cultural-adaptation-and-brazilian-validation-of-the-tool-25-question-geriatric-locomotive-function-scale
#10
Daniela Regina Brandão Tavares, Fania Cristina Santos
OBJECTIVE: The term Locomotive Syndrome refers to conditions in which the elderly are at high risk of inability to ambulate due to problems in locomotor system. For Locomotive Syndrome screening, the 25-Question Geriatric Locomotive Function Scale was created. The objective here was to translate, adapt culturally to Brazil, and study the psychometric properties of 25-Question Geriatric Locomotive Function Scale. METHOD: The translation and cultural adaptation of 25-Question Geriatric Locomotive Function Scale were carried out, thus resulting in GLFS 25-P, whose psychometric properties were analyzed in a sample of 100 elderly subjects...
January 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28119126/cognitive-deficit-in-hippocampal-dependent-tasks-in-werner-syndrome-mouse-model
#11
Khaoula Rekik, Bernard Francés, Philippe Valet, Cédric Dray, Cédrick Florian
Mammalian aging is often characterized by metabolic disturbances, cognitive declines and DNA repairs deficiency, but the underlying molecular mechanisms are still not well understood. Alterations in DNA repair can significantly exacerbate aging. Mammalian neuronal cells which accumulate unrepaired DNA damage over time could potentially lead to brain functions disorders. Focusing on the ATP-dependent RecQ-type DNA helicase, an enzyme involved in repair of double strand DNA, a mouse model of Werner syndrome (WS) had been proposed as a model of accelerated aging...
April 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28119079/deltamethrin-increases-the-fat-accumulation-in-3t3-l1-adipocytes-and-caenorhabditis-elegans
#12
Peiyi Shen, Tsung-Hsiu Hsieh, Yiren Yue, Quancai Sun, John M Clark, Yeonhwa Park
Research has shown that permethrin, a Type-I pyrethroid, increases triglyceride (fat) accumulation in adipocytes. Little is known, however, about any similar effect of deltamethrin, a Type-II pyrethroid, which produces a distinct syndrome of poisoning in mammals compared with permethrin. This study was therefore aimed to explore the role of deltamethrin on fat accumulation in 3T3-L1 adipocytes and Caenorhabditis elegans. Deltamethrin (10 μM) significantly increased the fat accumulation in 3T3-L1 adipocytes and wild type C...
March 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28058999/sex-differences-in-quadrupedal-walking-gaits-of-uner-tan-syndrome-cases-healthy-humans-and-nonhuman-primates
#13
Uner Tan
BACKGROUND: Uner Tan syndrome (UTS) cases with habitual quadrupedal locomotion (QL), impaired intelligence, and dysarthric or no speech predominantly use lateral sequence (LS) gait like nonprimates rather than the predominantly diagonal sequence (DS) gait of nonhuman primates. However, these studies neglected possible sex-related differences in these gait types. OBJECTIVES: (1) To assess the possible sex-related gait types in UTS cases, healthy infants and adults with requested QL, and the nonhuman primates...
March 2017: Neurological Research
https://www.readbyqxmd.com/read/28017942/-physical-activity-for-knee-osteoarthritis
#14
REVIEW
Masashi Nagao, Muneaki Ishijima, Haruka Kaneko, Yuji Takazawa, Hiroshi Ikeda, Kazuo Kaneko
Elder populations have been increasing in Japan and estimated 24 million people have knee osteoarthritis(OA). Recently, people have diverse sociological background and demand for participating sports has been growing. People may participate sports to prevent some diseases such as locomotive syndrome. According to the recent studies, excessive high impact sports increase the risk of OA, while daily life exercise decrease the risk. Epidemiological approach demonstrated that reduced knee extension muscle strength increases the risk of OA...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28017940/-the-significance-of-exercises-and-sports-in-the-locomotive-syndrome-prevention
#15
REVIEW
Hideaki Ishibashi
In Japan, the world's fastest aging country, the locomotive syndrome that shows a decrease in the mobility due to dysfunctions of the locomotor organs is a major risk factor of long-term care need in the old age. Exercises and sports habits are well reviewed to lead to the improvement and maintenance of motor function, and exercises are also useful in the prevention of a number of musculoskeletal diseases. In addition, several trials with the exercise intervention indicated improvement in motor function, suggesting exercises could prevent the locomotive syndrome...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28013290/uner-tan-syndrome-caused-by-a-homozygous-tubb2b-mutation-affecting-microtubule-stability
#16
Martin W Breuss, Thai Nguyen, Anjana Srivatsan, Ines Leca, Guoling Tian, Tanja Fritz, Andi H Hansen, Damir Musaev, Jennifer McEvoy-Venneri, Kiely N James, Rasim O Rosti, Eric Scott, Uner Tan, Richard D Kolodner, Nicholas J Cowan, David A Keays, Joseph G Gleeson
The integrity and dynamic properties of the microtubule cytoskeleton are indispensable for the development of the mammalian brain. Consequently, mutations in the genes that encode the structural component (the α/β-tubulin heterodimer) can give rise to severe, sporadic neurodevelopmental disorders. These are commonly referred to as the tubulinopathies. Here we report the addition of recessive quadrupedalism, also known as Uner Tan syndrome (UTS), to the growing list of diseases caused by tubulin variants. Analysis of a consanguineous UTS family identified a biallelic TUBB2B mutation, resulting in a p...
January 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/27943574/factors-associated-with-functional-limitations-in-the-daily-living-activities-of-japanese-hip-osteoarthritis-patients
#17
Kyoko Kondo, Seiya Jingushi, Satoko Ohfuji, Muroto Sofue, Moritoshi Itoman, Tadami Matsumoto, Yoshiki Hamada, Hiroyuki Shindo, Yoshio Takatori, Harumoto Yamada, Yuji Yasunaga, Hiroshi Ito, Satoshi Mori, Ichiro Owan, Genji Fujii, Hirotsugu Ohashi, Wakaba Fukushima, Akiko Maeda, Miki Inui, Shinji Takahashi, Yoshio Hirota
AIM: As society ages, there is a vast number of elderly people with locomotive syndrome. In this study, the factors associated with functional limitations in daily living activities evaluated by female hip osteoarthritis (OA) patients were investigated. METHODS: This study was a cross-sectional study. The subjects were 353 female patients who were newly diagnosed with hip OA at an orthopedic clinic with no history of hip joint surgery. Outcome indices were functional limitations in two daily living activities obtained from a questionnaire completed by the patients: (i) standing up (standing from a crouched position) and (ii) stair-climbing (climbing and/or descending stairs)...
December 10, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/27919650/association-between-dysfunction-of-upper-extremity-and-locomotive-syndrome-in-general-population
#18
Tsuyoshi Tajika, Atsushi Yamamoto, Noboru Oya, Chisa Okura, Satoshi Shinagawa, Takanori Kitagawa, Hiroki Kobayashi, Haku Iizuka, Kenji Takagishi
OBJECTIVE: This study investigated the relation between self-assessment of upper extremity function and locomotive syndrome in a general population. METHODS: Using the 25-question Geriatric Locomotive Function (GLFS-25) test, 320 Japanese people (115 men, 205 women, mean age 67.6 years, 40-92 years) were evaluated for locomotive dysfunction. All had completed a self-administered questionnaire including items for sex, weight, height, dominant hand, and the degree of frequency of hand in ADL...
December 2, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27862879/locomotive-syndrome-is-associated-with-large-blood-pressure-variability-in-elderly-hypertensives-the-japan-ambulatory-blood-pressure-prospective-jamp-substudy
#19
Yuki Imaizumi, Kazuo Eguchi, Takeshi Murakami, Tomohiro Saito, Satoshi Hoshide, Kazuomi Kario
Chronic pain, represented by locomotive syndrome (LS), and psychosocial factors are possible factors of blood pressure (BP) variability (BPV). The authors tested the hypothesis that there are links among LS, depression, and BPV. In 85 Japanese elderly hypertensive patients with normal daily activities, the authors performed ambulatory BP monitoring, determined the LS scale (LSS), and administered the Self-Rating Questionnaire for Depression (SRQD). The LSS score but not the SRQD score was associated with the standard deviation (SD) and coefficient of variation (CV) of daytime systolic BP (SBP) and SD of nighttime SBP (all P<...
November 15, 2016: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/27862616/topical-gabapentin-gel-alleviates-allodynia-and-hyperalgesia-in-the-chronic-sciatic-nerve-constriction-injury-neuropathic-pain-model
#20
M Shahid, F Subhan, N Ahmad, G Ali, S Akbar, K Fawad, R D E Sewell
BACKGROUND: Systemic gabapentin is a mainstay treatment for neuropathic pain though there are side-effects. Localized therapy may curtail such side-effects so a topical gabapentin dermal application was examined in the chronic constriction injury (CCI) model of neuropathic pain. METHODS: Partial denervation CCI was achieved by rat sciatic nerve ligation. Gabapentin gel (10% w/w) was applied three times daily on the ipsilateral or contralateral plantar surface of the hind-paw, whereas in a concurrent systemic study, gabapentin was intraperitoneally administered daily (75 mg/kg) for 30 days...
April 2017: European Journal of Pain: EJP
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