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Locomotive Syndrome

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https://www.readbyqxmd.com/read/29326173/transcriptional-regulator-zeb2-is-essential-for-bergmann-glia-development
#1
Li He, Kun Yu, Fanghui Lu, Jiajia Wang, Laiman N Wu, Chuntao Zhao, Qianmei Li, Xianyao Zhou, Hanmin Liu, Dezhi Mu, Mei Xin, Mengsheng Qiu, Q Richard Lu
Bergmann glia facilitate granule neuron migration during development and maintain the cerebellar organization and functional integrity. At present, molecular control of Bergmann glia specification from cerebellar radial glia is not fully understood. In this report, we show that Zeb2 (a.k.a. Sip1 or Zfhx1b), a Mowat-Wilson-syndrome-associated transcriptional regulator, is highly expressed in Bergmann glia, but hardly detectable in astrocytes in the cerebellum. The mice lacking Zeb2 in cerebellar radial glia exhibit severe deficits in Bergmann glia specification, and develop cerebellar cortical lamination dysgenesis and locomotion defects...
January 11, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29316856/food-functionality-research-as-a-new-national-project-in-special-reference-to-improvement-of-cognitive-and-locomotive-abilities
#2
Keiko Abe, Takumi Misaka
In Japan, where a super-aging society is realized, we are most concerned about healthy longevity, which would ascertain the wellness of people by improving their quality of life (QOL). In 2014, the Cabinet Office proposed a strategic innovation promotion programme, launching a national project for the development of the agricultural-forestry-fisheries food products with new functionalities for the next generation. In addition to focusing on a conventional prevention of lifestyle-associated metabolic syndromes, the project targets the scientific evidence of the activation of brain cognitive ability and the improvement of bodily locomotive function...
January 10, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29314714/behavioral-fragmentation-in-the-d1ct-7-mouse-model-of-tourette-s-syndrome
#3
Andrea Santangelo, Marco Bortolato, Laura J Mosher, Giuseppe Crescimanno, Giuseppe Di Giovanni, Emanuele Cassioli, Valdo Ricca, Maurizio Casarrubea
AIM: The transgenic D1CT-7 mouse is one of the best-characterized animal models of Tourette's syndrome (TS), exhibiting spontaneous tic-like Head-Body Twitches (HBT) and deficits in sensorimotor gating. This study is aimed at evaluating the behavioral dynamics of these mutants and their potential relevance to TS. METHODS: The behavior of D1CT-7 and Wild Type littermates was firstly assessed by considering frequencies and durations. To detect recurrent real-time behavioral sequences, the multivariate T-pattern analysis was employed...
January 3, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29305086/the-candidate-schizophrenia-risk-gene-dgcr2-regulates-early-steps-of-corticogenesis
#4
Aude Molinard-Chenu, Alexandre Dayer
BACKGROUND: Alterations in early steps of cortical circuit assembly are thought to play a critical role in vulnerability to schizophrenia (SZ), but the pathogenic impact of SZ-risk mutations on corticogenesis remains to be determined. DiGeorge syndrome critical region 2 (DGCR2) is located in the 22q11.2 locus, whose deletion is a major risk factor for SZ. Moreover, exome sequencing of individuals with idiopathic SZ identified a rare missense mutation in DGCR2, further suggesting that DGCR2 is involved in SZ...
November 21, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29285794/glial-lipid-droplets-and-neurodegeneration-in-a-drosophila-model-of-complex-i-deficiency
#5
Marie-Jeanne Cabirol-Pol, Bilal Khalil, Thomas Rival, Catherine Faivre-Sarrailh, Marie Thérèse Besson
Mitochondrial defects associated with respiratory chain complex I deficiency lead to heterogeneous fatal syndromes. While the role of NDUFS8, an essential subunit of the core assembly of the complex I, is established in mitochondrial diseases, the mechanisms underlying neuropathology are poorly understood. We developed a Drosophila model of NDUFS8 deficiency by knocking down the expression of its fly homologue in neurons or in glial cells. Downregulating ND23 in neurons resulted in shortened lifespan, and decreased locomotion...
December 29, 2017: Glia
https://www.readbyqxmd.com/read/29226660/bone-and-joint-diseases-in-present-and-future
#6
Yasuharu Nakashima, Ken Okazak, Koichiet Nakayama, Seiji Okada, Hideki Mizu-uchi
With the increase of elderly population, orthopaedic surgeons need to deal with the diseases related to aging, such as joint disorders and fragility fractures. The number of total joint replacements, for example, is two times more than it was 10 years ago. With these backgrounds, the Japanese Orthopaedic Association (JOA) has proposed the concept of locomotive syndrome; conditions under which the elderly have been receiving care services due to problems of the locomotive organs. To prevent geriatric or disuse syndrome, JOA is currently providing the care‒prevention programs such as the loco-check and loco-training...
January 2017: Fukuoka Igaku Zasshi, Hukuoka Acta Medica
https://www.readbyqxmd.com/read/29204126/pharmacokinetic-ambulatory-and-hyperthermic-effects-of-3-4-methylenedioxy-n-methylcathinone-methylone-in-rats
#7
Kristýna Štefková, Monika Židková, Rachel R Horsley, Nikola Pinterová, Klára Šíchová, Libor Uttl, Marie Balíková, Hynek Danda, Martin Kuchař, Tomáš Páleníček
Methylone (3,4-methylenedioxy-N-methylcathinone) is a synthetic cathinone analog of the recreational drug ecstasy. Although it is marketed to recreational users as relatively safe, fatalities due to hyperthermia, serotonin syndrome, and multi-organ system failure have been reported. Since psychopharmacological data remain scarce, we have focused our research on pharmacokinetics, and on a detailed evaluation of temporal effects of methylone and its metabolite nor-methylone on behavior and body temperature in rats...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29196797/sorting-nexin-3-mutation-impairs-development-and-neuronal-function-in-caenorhabditis-elegans
#8
Neide Vieira, Carlos Bessa, Ana J Rodrigues, Paulo Marques, Fung-Yi Chan, Ana Xavier de Carvalho, Margarida Correia-Neves, Nuno Sousa
The sorting nexins family of proteins (SNXs) plays pleiotropic functions in protein trafficking and intracellular signaling and has been associated with several disorders, namely Alzheimer's disease and Down's syndrome. Despite the growing association of SNXs with neurodegeneration, not much is known about their function in the nervous system. The aim of this work was to use the nematode Caenorhabditis elegans that encodes in its genome eight SNXs orthologs, to dissect the role of distinct SNXs, particularly in the nervous system...
December 1, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29161707/a-novel-animal-model-simulating-the-beginning-of-combat-exposure
#9
Dongsoo Kim, Chang Yul Kim, Hyojin Koo, Yong Heo, Kicheol Cheon
OBJECTIVE: Predator stress, social defeat stress, and fear conditioning animal models have been applied to investigate combat-related posttraumatic stress disorder (PTSD). However, no animal model psychopharmacological studies have investigated prevention of somatization of increased mental stress and fatigue at the beginning of combat exposure. This study utilized a novel animal model simulating the beginning of combat exposure that aided specification of a set of biomarkers. METHODS: Psychological stress was induced by both inescapable electric foot shock and noise stimuli...
November 22, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29128305/methamphetamine-induced-impulsivity-during-chronic-methamphetamine-treatment-in-rats-effects-of-the-taar-1-agonist-ro5263397
#10
Zhaoxia Xue, Justin N Siemian, Bernard N Johnson, Yanan Zhang, Jun-Xu Li
Impulsivity is an important personality trait associated with several clinical syndromes including drug abuse. While repeated drug exposure is known to increase certain behavioral responses, such as locomotion, to subsequent drug exposure, few studies have examined whether such sensitization develops for impulsive behavior. In the current study we tested the effects of methamphetamine acutely, during the course of, and upon discontinuation of chronic methamphetamine treatment on impulsive behavior in two models, the 5-choice serial reaction time task (5-CSRTT) and the delay-discounting task which measure impulsive action and impulsive choice, respectively...
November 8, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29115022/self-care-agency-lifestyle-and-physical-condition-predict-future-frailty-in-community-dwelling-older-people
#11
Chika Tanimura, Hiromi Matsumoto, Yasuko Tokushima, Junko Yoshimura, Shinji Tanishima, Hiroshi Hagino
The purpose of this 2 year longitudinal study was to identify the relationship between self-care agency, lifestyle, physical condition, and frailty among community-dwelling older people in a rural area of Japan. The participants were 133 older individuals aged 65 years or above. Data collection was conducted via face-to-face interviews using self-administered questionnaires. Background information, such as age, sex, current employment status, family structure, medication use, comorbidities, and knee and lower back pain, were assessed...
November 8, 2017: Nursing & Health Sciences
https://www.readbyqxmd.com/read/29100824/the-25-question-geriatric-locomotive-function-scale-predicts-the-risk-of-recurrent-falls-in-postoperative-patients-with-cervical-myelopathy
#12
Atsushi Kimura, Katsushi Takeshita, Hirokazu Inoue, Atsushi Seichi, Yosuke Kawasaki, Toshitaka Yoshii, Hiroyuki Inose, Takeo Furuya, Kazuhiro Takeuchi, Shunji Matsunaga, Shoji Seki, Mikito Tsushima, Shiro Imagama, Masao Koda, Masashi Yamazaki, Kanji Mori, Hirosuke Nishimura, Kenji Endo, Kei Yamada, Kimiaki Sato, Atsushi Okawa
BACKGROUND: Fall-induced injuries represent a major public health concern for older individuals. The relationship between risk of falling and the severity of locomotive syndrome (LS) remains largely unknown. METHODS: We conducted a retrospective analysis of patients who had undergone surgery from January 2012 to December 2013 and completed at least 1 year of follow-up at 12 participating institutes. Patients completed a questionnaire survey regarding their fall experience during a routine postoperative follow-up...
October 31, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29093169/age-and-speed-dependent-modulation-of-locomotor-gaits-in-dscam-2j-mutant-mice
#13
Louise Thiry, Maxime Lemieux, Frederic Bretzner
Locomotor gaits depend on the interplay between distributed spinal neural networks termed central pattern generators generating rhythmic and coordinated movements, primary afferents and descending supraspinal inputs. Recent studies demonstrated that the mouse display a rich repertoire of locomotor gaits. Changes in locomotor gaits occur in mutant mice lacking particular neurons or molecular signaling pathways implicated in the normal establishment of these neural networks Given the role of the Down Syndrome Cell Adherence Molecule (DSCAM) to the formation and maintenance of spinal interneuronal circuits and sensorimotor integration, we have investigated its functional contribution to locomotor gaits over a wide range of locomotor speeds using freely walking mice...
November 1, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29060496/freezing-of-gait-detection-using-temporal-spatial-and-physiological-features-with-a-support-vector-machine-classifier
#14
Parisa Tahafchi, Rene Molina, Jaimie A Roper, Kristen Sowalsky, Chris J Hass, Aysegul Gunduz, Michael S Okun, Jack W Judy
Freezing-of-Gait (FoG) is a syndrome of Parkinson's disease defined by episodes when patients show a complete inability to take a step or continue with their locomotion. In order to develop closed-loop therapeutic strategies, including deep brain stimulation, a reliable means of detecting freezing episodes is required. By using wearable accelerometers, freezing episodes can be detected with energy-based algorithms when the ratio of the energy in the freeze band (3 to 8 Hz) to that of the locomotion band (0...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29047351/lifestyle-factors-are-significantly-associated-with-the-locomotive-syndrome-a-cross-sectional-study
#15
Manabu Akahane, Shingo Yoshihara, Akie Maeyashiki, Yasuhito Tanaka, Tomoaki Imamura
BACKGROUND: The Japanese Orthopedic Association first proposed the concept of "locomotive syndrome" in 2007. It refers to circumstances in which elderly people need nursing care services or are at high risk of requiring such services within a short time. Recently, the public health burden of providing nursing care for elderly individuals has increased. Therefore, locomotive syndrome, and the means of preventing it, are a major public health focus in Japan. The purpose of this study was to investigate the relationships of lifestyle factors, such as smoking, alcohol consumption, sleep duration, and dental health, with locomotive syndrome...
October 18, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28979107/cognitive-impairment-associated-with-locomotive-syndrome-in-community-dwelling-elderly-women-in-japan
#16
Misa Nakamura, Fumie Tazaki, Kazuki Nomura, Taeko Takano, Masashi Hashimoto, Hiroshi Hashizume, Ichiro Kamei
In our worldwide aging society, elderly people should maintain cognitive and physical function to help avoid health problems. Dementia is a major brain disease among elderly people, and is caused by cognitive impairment. The locomotive syndrome (LS) refers to a condition in which people require healthcare services because of problems associated with locomotion. The purpose of this study was to determine the association between cognitive impairment and LS. Study participants were 142 healthy elderly female volunteers living in a rural area in Japan...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28933238/staged-decrease-of-physical-ability-on-the-locomotive-syndrome-risk-test-is-related-to-neuropathic-pain-nociceptive-pain-shoulder-complaints-and-quality-of-life-in-middle-aged-and-elderly-people-the-utility-of-the-locomotive-syndrome-risk-test
#17
Shiro Imagama, Yukiharu Hasegawa, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Kenyu Ito, Mikito Tsushima, Yoshihiro Nishida, Naoki Ishiguro
OBJECTIVES: A locomotive syndrome (LS) risk test for evaluation of physical ability is recently proposed. The objective of this study is to evaluate the utility of this test by examining physical ability, neuropathic pain, nociceptive pain, shoulder complaints, and quality of life (QOL). METHODS: A prospective cohort study was conducted in 523 subjects (240 males, 283 females; mean age: 63.3 years) at a health checkup. Data collected using visual analog scales (VAS) for shoulder pain, low back pain, sciatica, and knee pain, neuropathic pain, shoulder complaint, body mass index (BMI), osteoporosis, and SF-36 were compared among three LS risk stages...
November 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28932003/quantitative-assessment-of-locomotive-syndrome-by-the-loco-check-questionnaire-in-older-japanese-females
#18
Sachiko Noge, Tatsuo Ohishi, Takuya Yoshida, Hiromichi Kumagai
[Purpose] Locomotive syndrome (LS) is a condition by which older people may require care service because of problems with locomotive organs. This study examined whether the loco-check, a 7-item questionnaire, is useful for quantitatively assessing the severity of LS. [Subjects and Methods] Seventy-one community dwelling Japanese females aged 64-96 years (81.7 ± 8.0 years) participated in this study. The associations of the loco-check with thigh muscle mass measured by X-ray CT, physical performance, nutritional status, and quality of life (QOL) were investigated...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28927741/associations-of-the-step-up-test-and-lower-limb-dysfunction-a-post-hoc-analysis-of-a-prospective-cohort-study
#19
Kiyoshi Kita, Yoshihiro Fukumoto, Yukihide Nishimura, Akihiko Kasuya, Tsuyoshi Asai
BACKGROUND: Step-up ability is considered to be associated with lower limb dysfunction. The objective of this research was to assess the height of the tallest step that could be mounted and to investigate its association with lower limb dysfunction. METHODS: We previously conducted a two-year follow-up prospective cohort study. The study subjects were 119 patients receiving physiotherapy or exercise therapy at an orthopedic surgery clinic. The items evaluated were step-up ability (maximum step height), the timed up and go test, one-leg standing time and the 5-question Geriatric Locomotive Function Scale...
January 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28912387/-osteoporosis-liaison-service-and-exercise-regimens-based-on-locomotive-syndrome
#20
Hideaki Ishibashi
The purpose of Osteoporosis Liaison Service(OLS)is primary and secondary prevention of osteoporosis and fragility fracture by multiple medical occupations. Exercise instruction and exercise intervention are important factors in OLS. Exercise has effects of increasing bone density and preventing falls. In OLS, it is also necessary to disseminate knowledge on osteoporosis and fractures to the public. Main measures against locomotive syndrome(LS), meaning weakening of ambulatory ability, are exercise and nutrition, and the LS prevention campaign is thought to lead to prevention of falls...
2017: Clinical Calcium
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