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Seminal plasma allergy

J-P Allam, G Haidl, N Novak
A semen allergy is a type I reaction. Reliable figures about incidence/prevalence are not available. Symptoms can be characterized as local and systemic. After exposure to ejaculate, the patient may experience itching and swelling at points of contact, while systemically it may also lead to generalized urticaria with angioedema or higher grade anaphylaxis. As triggering allergens, substances in seminal plasma (SP) have been identified, which can be SP typical or SP atypical. Reactions against spermatozoa have not yet been clearly proven...
December 2015: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
J Eubel, T L Diepgen, E Weisshaar
BACKGROUND: The genital area has a high exposure to various allergens that are not always obvious. Out of shame patients may not complain about symptoms in this area. Moreover, diagnosis and therapy are often not primarily conducted by a dermatologist and allergologist. Therefore, many cases of allergic diseases in the genital area remain undetected. OBJECTIVES: Which type I and type IV allergies occur in the genital area? Which allergens are currently of importance? Which are the characteristics of allergic diseases in the genital area? What are the symptoms and differential diagnoses? What to focus on when taking medical history and in clinical diagnostics? MATERIALS AND METHODS: The current medical literature regarding allergic diseases in the genital area is discussed...
January 2015: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
L Kofler, H Kofler, L Mattsson, J Lidholm
Allergy to human seminal plasma (HSP) is rare. It presents with a variety of symptoms, ranging from localized changes to generalized reactions or even anaphylactic shock. Symptoms typically start within minutes to one hour after exposure. Diagnosis is based on history, evidence of specific IgE antibodies and skin prick testing (SPT). A 25-year-old Caucasian woman presented with eyelid swelling, generalized urticaria and dyspnea immediately after unprotected coitus with her partner. No symptoms occurred when barrier contraception was used...
April 2012: European Annals of Allergy and Clinical Immunology
Maria Basagaña, Borja Bartolome, Carlos Pastor-Vargas, Lars Mattsson, Jonas Lidholm, Moises Labrador-Horrillo
BACKGROUND: The existence of IgE binding to dog dander extract without IgE antibodies against the described dog allergens (Can f 1, 2, 3 and 4) implies the presence of other dog allergens yet to be identified. Recently, an IgE-binding protein was isolated from dog urine and identified as prostatic kallikrein; it has been named Can f 5. Cross-reactivity between a dog dander allergen and human prostate-specific antigen (PSA) has been described. The aim of this study was to identify the dog dander allergen that presents cross-reactivity with PSA and demonstrate its clinical relevance in our patient with human seminal plasma allergy...
2012: International Archives of Allergy and Immunology
Ole D Wolthers
Case reports of women with the rare condition of human seminal plasma allergy have indicated that the condition may be associated with life-threatening anaphylactic reactions in relation to coitus. Few observations, if any, of long-term outcome of the condition are available. The aim of this paper was to present a case diagnosed in an 18-year-old girl who presented with generalized urticaria, nasal congestion and secretion, conjunctivitis, and periorbital and labial oedema 6-8 hours after coitus. During five years of followup the condition improved clinically significantly...
2012: Case Reports in Medicine
Woo-Jung Song, Deok-In Kim, Min-Hye Kim, Min-Suk Yang, Yoon-Jeong Kim, Sae-Hoon Kim, Sang-Heon Cho, Kyung-Up Min, Yoon-Seok Chang
Human seminal plasma allergy is a rare phenomenon. Its clinical manifestations are diverse, and range from mild local pruritus to fatal anaphylaxis. Treatment varies with severity of the reactions: abstinence, condom usage or immunotherapy (subcutaneous or intravaginal) with seminal fluid. Local allergic reactions can be managed by prophylactic use of antihistamines or local cromolyn cream. A 33-year-old female visited the Asthma and Allergy Clinic in Seoul National University Bundang Hospital for the recurrent generalized urticarial reactions after sexual intercourse...
October 2011: Asia Pacific Allergy
Cynthia Frapsauce, Isabelle Berthaut, Vanina de Larouziere, Emmanuelle Mathieu d'Argent, Jean-Eric Autegarden, Hanene Elloumi, Jean-Marie Antoine, Jacqueline Mandelbaum
OBJECTIVE: To raise the possibility that pregnancy can be obtained by assisted reproductive techniques in patients with human seminal plasma allergy. DESIGN: Case report. SETTING: University hospital. PATIENT(S): A woman consulted for a 3-year primary infertility. She reported lack of intercourse because of a seminal plasma allergy. INTERVENTION(S): One intrauterine insemination associated with antihistamine treatment was performed with carefully washed spermatozoa...
July 2010: Fertility and Sterility
Lorenz Müller, Monique Vogel, Michael Stadler, Renato Truffer, Eliane Rohner, Beda M Stadler
Antigenic cross-reactivity has been described between the venom allergen (antigen 5) and mammalian testis proteins. Based on an allergen database we have previously shown that allergens can be represented by allergen motifs. A motif group was found containing venom antigen 5 sequences from different vespids. Using an optimized amino acid profile based on antigen 5 sequences for searching cross-reactive proteins, three human semen proteins belonging to the family of cysteine-rich secretory proteins (hCRISP) were found in the Swiss Protein database...
August 2008: Molecular Immunology
Piotr Jedrzejczak, Leszek Pawelczyk
We report a case of a 32-year-old woman with seminal fluid allergy and secondary infertility. She was unable to have unprotected intercourses due to hypersensitivity to the sperm of her spouse. The symptoms started after the delivery of her first child. She was referred to our division for desensitization by means of the intravaginal rush method. The patient was hospitalized for monitoring, and an intravenous line was placed. The first attempt of desensitization was unsuccessful, because of her general hypersensitivity reaction...
November 2007: Ginekologia Polska
Mary Lee-Wong, Jennifer S Collins, Cyrus Nozad, David J Resnick
BACKGROUND: Human seminal plasma hypersensitivity is a rare disorder that is often misdiagnosed. While this disorder is well described in the allergy and immunology literature, few cases exist in the gynecologic literature. CASE: A young woman presented to our allergy clinic with recurrent vaginal burning, swelling, and itching occurring approximately 10 minutes postcoitally. Semen allergy was suspected. Using her partner's semen, intradermal testing produced 1...
February 2008: Obstetrics and Gynecology
Maria Basagaña, Borja Bartolomé, Carlos Pastor, Ferran Torres, Rosario Alonso, Fernando Vivanco, Anna Cisteró-Bahíma
BACKGROUND: Human seminal plasma (HSP) allergy is uncommon, with symptoms ranging from vulvovaginal pruritus to life-threatening anaphylaxis. Although several seminal plasma allergens have been reported and their molecular masses have been estimated to range between 12 and 75 kd, the prostate-specific antigen (PSA) has recently been identified as a causative allergen. Given that in a large number of cases symptoms appeared during or after the first intercourse, a cross-reactivity phenomenon might be implicated...
January 2008: Journal of Allergy and Clinical Immunology
Gennaro Liccardi, Gianenrico Senna, Giuseppina Rotiroti, Gennaro D'Amato, Giovanni Passalacqua
OBJECTIVE: To determine how sex and intimate contacts can represent a risk factor for allergic reactions, because they may favor direct contact with sensitizing substances. DATA SOURCES: We collected in this review the available literature on this subject. The MEDLINE database was searched by a combination of keywords: sex OR sexual intercourse OR kiss OR seminal plasma OR condom AND allergy OR allergic reaction. STUDY SELECTION: The studies retrieved were independently evaluated by the authors and included in this review based on their clinical pertinence (i...
November 2007: Annals of Allergy, Asthma & Immunology
U M Winter, W Harth, R Treudler, J C Simon
Human seminal plasma allergy (HSPA) is a rare allergic reaction to specific protein fractions of seminal plasma, whereof PSA seems to be a relevant allergen. Predominantly Type I-immunoreactions can occur. The main symptoms are localized and generalized urticaria and sometimes anaphylactic symptoms. The diagnosis is based on history, skin tests and on the determination of specific IgE-levels for (un)fractionated seminal plasma. Here we report a patient with recurrent episodes of generalized urticaria after unprotected sexual intercourse and positive prick-test-reaction on seminal plasma...
August 2008: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Gabriele C Nist, Peter von den Driesch
Allergies to sperm are very uncommon. A 23-year old woman with atopic dermatitis complained of three attacks of angioedema, urticaria, wheezing and weakness. When questioned about factors causing exercise-induced anaphylaxis, the patient reported having had sexual intercourse with the same partner one hour before each event. When using condoms, no symptoms occurred. Human seminal plasma allergy was confirmed by positive skin testing with the partner's sperm. Specific IgE-antibodies against human seminal plasma were not found...
January 2007: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
L Ferré-Ybarz, M Basagaña, B Coroleu, B Bartolomé, A Cisteró-Bahima
Human seminal plasma allergy in women is an uncommon phenomenon. A great variety of reactions ranging from local swelling to generalized systemic reactions have been described, and local symptoms have often been misdiagnosed as chronic vulvovaginitis. Sperm barriers, such as condoms, are the most widely advocated method for avoiding these reactions; however this is not acceptable to couples who wish to have children. We present a case of a woman with human seminal plasma allergy who became pregnant after a fourth cycle of artificial insemination...
2006: Journal of Investigational Allergology & Clinical Immunology
Michaela Luconi, Gianni Forti, Elisabetta Baldi
Mammalian spermatozoa acquire the ability to swim during their transit from the testis to the oviduct under the control of several external and intracellular factors. These factors play also a pivotal role in regulating acquisition of hyperactivated motility and during the process of chemotaxis. This review summarizes the involvement of such factors in acquisition and maintenance of sperm motility, hyperactivation and chemotaxis, focusing in particular on the molecular bases of asthenozoospermia, a pathology of seminal plasma characterized by reduced sperm motility, which is one of the main causes of male infertility...
May 1, 2006: Frontiers in Bioscience: a Journal and Virtual Library
Stephan Weidinger, J Ring, F M Köhn
Human seminal plasma hypersensitivity has to be differentiated from allergic reactions to latex, spermicidal agents, local anesthetics or components of lubricants. The present review article discusses IgE-mediated allergic reactions (type I) to specific components of the seminal plasma. Such incidents are rare, even though there seems to be a considerable number of unreported cases. Since the first publication in 1958, human seminal plasma allergy has been increasingly recognized, and approximately 80 cases have been described...
2005: Chemical Immunology and Allergy
Aly Cohen, Mary Lee Wong, David Resnick
Human seminal plasma protein hypersensitivity is a rare disorder. Since the first case report in 1958, allergic reactions to semen have gone relatively unnoticed or improperly diagnosed. Dozens of medical case reports and research prove that allergy to seminal fluid is a legitimate health concern.
July 2004: Allergy and Asthma Proceedings:
A Shah, C Panjabi
No abstract text is available yet for this article.
June 2004: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Oksana Babula, Ann Marie Bongiovanni, William J Ledger, Steven S Witkin
OBJECTIVE: Patients with vulvar vestibulitis syndrome and control subjects were tested for evidence of allergy to seminal fluid to differentiate women with a clinical diagnosis of vulvar vestibulitis syndrome into discrete categories. STUDY DESIGN: Plasma samples from 52 women with vulvar vestibulitis syndrome and 43 control subjects were tested for immunoglobulin E antibodies to seminal fluid, total immunoglobulin E, interleukin-4, and interleukin-12 by enzyme-linked immunosorbent assay...
March 2004: American Journal of Obstetrics and Gynecology
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