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Masahiro Fukuyama, Yohei Sato, Yoshimi Yamazaki, Manabu Ohyama
Panfolliculoma (PF) is a rare benign tumor with signs of differentiation toward all components of the hair follicle (HF). Cystic panfolliculoma (CPF) is a subset of PF with histological similarity to trichofolliculoma making the differential diagnosis difficult in some cases. Immunohistopathological investigations of PF have been reported; however, previous studies focused mostly on the expression profile of the outer root sheath markers. A panel of antibodies was developed and used for the detection of the expression of cytokeratin (CK) 10, CK13, CK14, CK15, hair-hard keratin (AE13), and EpCAM within the lesion, supporting the differentiation of all epithelial lineages of the HF and the diagnosis of CPF...
June 20, 2017: Journal of Cutaneous Pathology
Noriyuki Misago, Shin-Ichi Ansai, Takaya Fukumoto, Takashi Anan, Tetsunori Kimura, Tomokazu Nakao
Some authors have reported that the secondary hair follicles in trichofolliculomas (TF) undergo regressive changes and are subsequently replaced by the developed sebaceous elements, and that folliculosebaceous cystic hamartoma (FSCH) is a TF at a very late stage. In the present study, we revaluated the histopathological features of 40 TF lesions, focusing on their chronological changes. The results of the present study indicate that while the secondary follicles in the TF exhibited the hair cycle, the normal hair cycle was out of control, and tertiary hair follicles randomly developed from the involuting secondary follicles...
March 31, 2017: Journal of Dermatology
Ashok Sangwaiya, Shilpa Bairwa, Shivani Kalhan, Puja Sharma, Rahul N Satarkar
Trichoadenoma is a rare benign, slowly growing, cutaneous tumour of the hair follicle first described by Nikolowski in 1958. It presents as a non-specific nodule over the face or buttocks. However, unusual sites such as the neck, upper arm, thigh, shoulder, and shaft of the penis may also be affected. The tumour is less mature than a trichofolliculoma and is more differentiated than a trichoepithelioma with a differentiation towards the infundibular portion of the pilosebaceous canal. Histologically, it consists of numerous infundibulocystic structures present throughout the dermis, few of which are lined by eosinophilic epidermal cells with attempted glandular formation and contain laminated keratin, without evidence of hair follicle formation...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
D Romero-Pérez, M García-Bustinduy, B Cribier
No abstract text is available yet for this article.
March 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
Eun-Jae Shin, Ki-Heon Jeong, Min-Kyung Shin
No abstract text is available yet for this article.
August 2016: Annals of Dermatology
Daniel D Bikle, Yan Jiang, Thai Nguyen, Yuko Oda, Chia-Ling Tu
1,25 dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, and calcium regulate epidermal differentiation. 1,25(OH)2D exerts its effects through the vitamin D receptor (VDR), a transcription factor in the nuclear hormone receptor family, whereas calcium acts through the calcium sensing receptor (Casr), a membrane bound member of the G protein coupled receptor family. We have developed mouse models in which the Vdr and Casr have been deleted in the epidermis ((epid) Vdr (-∕-) and (epid) Casr (-∕-))...
2016: Frontiers in Physiology
Huda Al-Ghadeer, Deepak P Edward
A 6-year-old male presented with a protruding hair emerging from a temporally located nodule on his left upper eyelid 5mm above the eyelid margin since birth. The lesion was excised and sent to histopathology. The features were consistent with congenital sebaceous trichofolliculoma, a rare hamartomatous skin lesion.
May 2017: Ophthalmic Plastic and Reconstructive Surgery
Krista N Larson, Patrick O'Shea, Daniel C Zedek, Dean S Morrell
Hair follicle nevi are rare, benign, congenital hamartomas that usually occur in the distribution of the first brachial arch. Histopathologically, the distinction between hair follicle nevus, trichofolliculoma, and accessory tragus has recently come into question, and it may be that they are all on a spectrum of the same condition. We report the case of a 7-day-old boy who presented with a "tag"-like lesion on his midline chin that had been present since birth. Biopsy of the lesion proved it to be a hair follicle nevus...
March 2016: Pediatric Dermatology
Oscar Tellechea, José Carlos Cardoso, José Pedro Reis, Leonor Ramos, Ana Rita Gameiro, Inês Coutinho, António Poiares Baptista
Benign follicular tumors comprise a large and heterogeneous group of neoplasms that share a common histogenesis and display morphological features resembling one or several portions of the normal hair follicle, or recapitulate part of its embryological development. Most cases present it as clinically nondescript single lesions and essentially of dermatological relevance. Occasionally, however, these lesions be multiple and represent a cutaneous marker of complex syndromes associated with an increased risk of visceral neoplasms...
November 2015: Anais Brasileiros de Dermatologia
Michiko Yuki, Katsuhiko Yoshizawa, Yuko Emoto, Takashi Yuri, Yuichi Kinoshita, Airo Tsubura, Ichiro Kurokawa
A single intraperitoneal injection of 50 or 75 mg/kg N-methyl-N-nitrosourea in male Sprague-Dawley rats at 4 weeks of age, dose-dependently resulted in cutaneous epithelial cysts and tumors of pilosebaceous origin. Cysts were composed of epidermal cysts or mixed epidermal and inner root sheath hybrid cysts. The majority of induced tumors were keratoacanthomas. A few tumors were trichofolliculomas, trichoblastomas, pilomatricomas, or sebaceous adenomas. All tumors were benign pilosebaceous tumors. Keratoacanthomas were crater-shaped tumors with thick infoldings of epithelium containing keratohyalin granules (epidermal lip) that abruptly changed to epithelium containing trichohyalin granules...
January 2016: Anticancer Research
Richard B Mertens, Mariza N de Peralta-Venturina, Bonnie L Balzer, David P Frishberg
Initial investigations reported GATA3 to be a sensitive and relatively specific marker for mammary and urothelial carcinomas. Recently, GATA3 expression has been described in several other epithelial tumors. However, there has been only limited investigation of GATA3 expression in cutaneous epithelial tumors. The objective of this study was to examine the immunohistochemical expression of GATA3 in a wide variety of cutaneous epithelial neoplasms. GATA3 expression was evaluated in 99 benign and 63 malignant cutaneous epithelial tumors...
December 2015: American Journal of Dermatopathology
Yasemin Yuyucu Karabulut, Engin Şenel, Hacı Halil Karabulut, Yasemin Dölek
BACKGROUND: Hair follicle nevus is a rare, congenital hamartoma with follicular differentiation characterized histologically by numerous, tiny, mature hair follicles. Trichofolliculoma, the histopathological features of which are quite similar to those of hair follicle nevus, is also a hamartoma that differs from hair follicle. Accessory tragus is a relatively common, benign congenital abnormality of the external ear with an incidence rate of 1 to 10 per 1,000 live births. OBJECTIVE: This study seeks to assess the discriminatory value of currently available, histological criteria in the differential diagnosis of hair follicle nevus, accessory tragi and trichofolliculoma...
July 2015: Anais Brasileiros de Dermatologia
L Knani, S Ben Abdelkarim, N Ben Rayana, F Ben Hadj Hamida, M Mokni
No abstract text is available yet for this article.
October 2015: Journal Français D'ophtalmologie
Sudhir Uk Nayak, Shrutakirthi D Shenoi, V Geetha, Smitha Prabhu, Bhawna Nagel
Trichofolliculomas are benign hair follicle hamartomas which were initially considered as hair follicle tumors. Usually presenting as a solitary lesion associated with a tuft of vellus hairs, multiple trichofolliculomas are rare. Trichofolliculomas are characterized by a histopathological feature of dermal keratin cyst with cyst wall showing radiating hair follicles. We report this case for the rare presentation of multiple trichofolliculomas on the face which clinically mimicked multiple trichoepitheliomas...
March 2015: Indian Journal of Dermatology
M-H Jégou-Penouil, C Bourseau-Quetier, S Cajanus, J-L Rigon, M Risbourg, N Kluger
BACKGROUND: Trichofolliculoma is a rare benign tumor consisting of a pilosebaceous follicle hamartoma. While diagnosis of this condition is generally straightforward, fortuitous discovery of an atypical presentation can occur during histological examination of a biopsy or surgical sample. PATIENTS AND METHODS: We report herein on 8 patients aged between 8 and 75 years illustrating the wide spectrum of clinical presentation of this lesion, for which there are numerous differential diagnoses in the event of atypical clinical (lack of central whitish hair plug) or topical features (extra-facial site)...
March 2015: Annales de Dermatologie et de Vénéréologie
F Fabre, M Canihac, T Jouary
No abstract text is available yet for this article.
November 2014: Annales de Dermatologie et de Vénéréologie
Asmaa Gaber Abdou, Nancy Youssef Asaad
Sebaceous trichofolliculoma is considered as hamartomatous lesion with follicular differentiation. In this study, we demonstrated a classic histopathologic picture of sebaceous trichofolliculoma in a 65-year-old male presented with large sized right cheek swelling.
October 2014: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Jyotsna Naresh Bharti, Biswajit Dey, Parul Gautam, Parth Desai, Vinay Kamal
Trichofolliculoma represents abortive differentiation of pluripotent skin cells toward hair follicles. We present a case of an adult female with lobulated mass involving the tip and dorsum of the nose for the last 15 years. The systemic and radiological examinations were noncontributory. The clinical diagnosis was thought to be dermoid cyst. The fine-needle aspiration cytology of the lobulated mass was performed, and the cytology smears showed anucleate squames admixed with sebaceous cells. The possibility of a benign skin adnexal lesion was suggested...
January 2014: International Journal of Trichology
Lea Heuer, Michael Stötter, Maja Eydner, Christina Puff, Sven Kleinschmidt
Two guinea pigs (Cavia porcellus) were presented with a clinical history of a chronic, unresponsive skin disorder with scaling, itching and alopecia. After clinical differential diagnoses (e. g. ectoparasitosis, dermatomycosis, endocrinopathy or allergy) had been ruled out, a skin biopsy revealed an epitheliotropic lymphoma (Mycosis fungoides). The pathohistological examination of the skin showed focal intraepidermal accumulations of tumorous lymphocytes also known as pautrier microabscesses. A full necropsy displayed also metastases in lymph nodes, and additionally tumor cells within skeletal muscle, heart, lung, liver and kidney in one animal...
July 2014: Berliner und Münchener Tierärztliche Wochenschrift
Peng Sun, Kazuhide Watanabe, Magid Fallahi, Briana Lee, Megan E Afetian, Catherine Rheaume, Di Wu, Valerie Horsley, Xing Dai
Understanding the epigenetic mechanisms that control the activation of adult stem cells holds the promise of tissue and organ regeneration. Hair follicle stem cells have emerged as a prime model to study stem cell activation. Wnt/β-catenin signaling controls multiple aspects of skin epithelial regeneration, with its excessive activity promoting the hyperactivation of hair follicle stem/progenitor cells and tumorigenesis. The contribution of chromatin factors in regulating Wnt/β-catenin pathway function in these processes is unknown...
July 15, 2014: Proceedings of the National Academy of Sciences of the United States of America
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