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https://www.readbyqxmd.com/read/28633259/mycobacterium-chimaera-infection-after-cardiac-surgery-first-canadian-outbreak
#1
Raphael Hamad, Pierre-Emmanuel Noly, Louis P Perrault, Michel Pellerin, Philippe Demers
Recently reported in Europe and United States, disseminated Mycobacterium chimaera infection is a novel clinical entity linked to point contamination of Stockert 3T heater-cooler units used for cardiopulmonary bypass. We present here the first two cases in Canada. Both patients presented with nonspecific extracardiac symptoms 1 year after undergoing minimally invasive mitral surgical repair. Before the right diagnosis was established, the patients were initially treated with prednisone for suspected sarcoidosis...
July 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28631201/seven-esophageal-perforation-cases-after-aortic-replacement-stenting-for-thoracic-aortic-dissection-or-aneurysm
#2
Yoshihisa Yaguchi, Yoshimasa Kumata, Masahiro Horikawa, Takashi Kiyokawa, Tsuyoshi Inaba, Ryoji Fukushima
BACKGROUND: Esophageal perforation after aortic replacement/stenting for aortic dissection or aneurysm is a rare but severe complication. However, its cause, standard treatment, and prognosis are unclear. We analyzed the treatment and outcome retrospectively from seven cases experienced at our hospital. CASE PRESENTATION: The median age of the patients was 70 years (range, 41-86), and six of the seven cases were male. As the first treatment, aortic replacement techniques were performed in five, and thoracic endovascular aortic repair (TEVAR) procedure was performed in two...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28630304/transitional-turbulent-spots-and-turbulent-turbulent-spots-in-boundary-layers
#3
Xiaohua Wu, Parviz Moin, James M Wallace, Jinhie Skarda, Adrián Lozano-Durán, Jean-Pierre Hickey
Two observations drawn from a thoroughly validated direct numerical simulation of the canonical spatially developing, zero-pressure gradient, smooth, flat-plate boundary layer are presented here. The first is that, for bypass transition in the narrow sense defined herein, we found that the transitional-turbulent spot inception mechanism is analogous to the secondary instability of boundary-layer natural transition, namely a spanwise vortex filament becomes a [Formula: see text] vortex and then, a hairpin packet...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28627452/engineering-of-unconventional-yeast-yarrowia-lipolytica-for-efficient-succinic-acid-production-from-glycerol-at-low-ph
#4
Zhiyong Cui, Cuijuan Gao, Jiaojiao Li, Jin Hou, Carol Sze Ki Lin, Qingsheng Qi
Yarrowia lipolytica is considered as a potential candidate for succinic acid production because of its innate ability to accumulate citric acid cycle intermediates and its tolerance to acidic pH. Previously, a succinate-production strain was obtained through the deletion of succinate dehydrogenase subunit encoding gene Ylsdh5. However, the accumulation of by-product acetate limited further improvement of succinate production. Meanwhile, additional pH adjustment procedure increased the downstream cost in industrial application...
June 13, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28625750/postoperative-delirium-in-patients-undergoing-off-pump-coronary-artery-bypass-grafting-according-to-the-anesthetic-agent-a-retrospective-study
#5
Chung-Sik Oh, Sewon Park, Seung Wan Hong, Woon-Seok Kang, Tae-Gyoon Yoon, Seong-Hyop Kim
OBJECTIVE: To evaluate the effect of two anesthetic agents (sevoflurane or propofol) on postoperative delirium (POD) in patients undergoing off-pump coronary artery bypass grafting (CABG). DESIGN: Retrospective observational design. SETTING: University hospital. PARTICIPANTS: Two hundred ninety-two patients undergoing off-pump CABG who were anesthetized with sevoflurane or propofol. METHODS: Incidence of POD, laboratory data, and pre-, intra-, and 24-hour postoperative clinical variables were reviewed retrospectively...
February 12, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28623318/zipa-and-ftsa-stabilize-ftsz-gdp-miniring-structures
#6
Yaodong Chen, Haiyan Huang, Masaki Osawa, Harold P Erickson
The cytokinetic division ring of Escherichia coli comprises filaments of FtsZ tethered to the membrane by FtsA and ZipA. Previous results suggested that ZipA is a Z-ring stabilizer, since in vitro experiments it is shown that ZipA enhanced FtsZ assembly and caused the filaments to bundles. However, this function of ZipA has been challenged by recent studies. First, ZipA-induced FtsZ bundling was not significant at pH greater than 7. Second, some FtsA mutants, such as FtsA* were able to bypass the need of ZipA...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28617693/brukhonenko-s-autojector-the-first-apparatus-for-cardiopulmonary-bypass-and-extracorporeal-life-support
#7
Sergey P Glyantsev, Pavel M Bogopolsky, Vakhtang Tchantchaleishvili
Sergey Brukhonenko was a prominent Soviet physician-scientist who from 1922 to 1924 developed a methodology for perfusing a canine head and keeping it alive using the first extracorporeal life support device he created called "Autojector." From 1926 to 1927, in collaboration with surgeon Nikolay Terebinsky, he performed a series of perfusion experiments of the entire canine body using a more advanced model of Autojector. Subsequently, Brukhonenko concluded the possibility of extending this methodology to heart surgery...
June 13, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28617371/-cognitive-dysfunction-and-content-of-inflammatory-markers-in-patients-after-coronary-artery-bypass-graft
#8
D A Ovchinnikov, D D Amosov, E A Vorobyov, V V Garnyuk, P P Beltiukov, V K Grebennik, M L Gordeev, E R Barantsevich
AIM: To study the relationship between the content of inflammatory biomarkers and cognitive function in patients after coronary artery bypass graft (CABG) performed in condition of artificial blood circulation (ABC) or open-heart surgery (OHS). MATERIAL AND METHODS: Twenty-nine patients with ischemic heart disease who survived CABG, mean age 62.4±6.2 years, were studied. The ABC group (n=18) and OHS group (n=11) were matched for age and sex. Patients underwent standard clinical examination as well as neurological examination and neuropsychological testing...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28616401/recent-advancements-in-stent-therapy-in-patients-with-malignant-gastroduodenal-outlet-obstruction
#9
REVIEW
Hironari Kato, Koichiro Tsutsumi, Hiroyuki Okada
Gastric outlet obstruction (GOO) is one of severe comorbidities caused by many kinds of malignant diseases and is associated with not only degradation of patients' quality of life but also mortality. Although surgical bypass is one of the main therapies for malignant GOO, it is often difficult to perform in end-stage patients. The deployment of self-expandable metallic stents (SEMSs) has recently become a viable alternative to surgical bypass for malignant GOO. This technique is less invasive and more effective, particularly in patients with poor prognoses...
April 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28615192/access-to-hyperacute-stroke-services-across-canadian-provinces-a-geospatial-analysis
#10
Prasanna Venkatesan Eswaradass, Richard H Swartz, Jamey Rosen, Michael D Hill, M Patrice Lindsay
BACKGROUND: Canada's vast geography creates challenges for ensuring prompt transport to hospital of patients who have had a stroke. We sought to determine the proportion of people across various Canadian provinces for whom hyperacute stroke services are accessible within evidence-based time targets. METHODS: We calculated, for the 8 provinces with available data, drive-time polygons on a map of Canada that delineated the area around stroke centres and emergency medical services (EMS) base centres to which one can drive in 3...
June 14, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28612026/postoperative-compensatory-ammonium-excretion-subsequent-to-systemic-acidosis-in-cardiac-patients
#11
Friederike Roehrborn, Daniel-Sebastian Dohle, Indra N Waack, Konstantinos Tsagakis, Heinz Jakob, Johanna K Teloh
BACKGROUND: Postoperative acid-base imbalances, usually acidosis, frequently occur after cardiac surgery. In most cases, the human body, not suffering from any severe preexisting illnesses regarding lung, liver, and kidney, is capable of transient compensation and final correction. The aim of this study was to correlate the appearance of postoperatively occurring acidosis with renal ammonium excretion. MATERIALS AND METHODS: Between 07/2014 and 10/2014, a total of 25 consecutive patients scheduled for elective isolated coronary artery bypass grafting with cardiopulmonary bypass were enrolled in this prospective observational study...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28611938/anatomic-study-of-the-vascular-perfusion-of-the-sternum-and-its-clinical-relevance-in-deep-sternal-wound-infection
#12
Nick Spindler, Florian Kaatz, Christine Feja, Christian Etz, Friedrich-Wilhelm Mohr, Ingo Bechmann, Christoph Josten, Stefan Langer, Sabine Loeffler
Introduction: Deep sternal wound infections (DSWI) are a rare but devastating complication after median sternotomy. Minor perfusion in bone and soft tissue, especially after recruiting the internal mammary artery for bypass supports the development of wound infection and nonunion of the sternal bone. The aim of the study was the macroscopic and radiological presentation of the vascular system supplying the sternum, in particular the compensating blood supply routes in the event that the internal mammary artery is no longer available after use as a bypass vessel...
2017: GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
https://www.readbyqxmd.com/read/28611006/intensive-versus-moderate-atorvastatin-therapy-and-one-year-graft-patency-after-cabg-rationale-and-design-of-the-active-aggressive-cholesterol-therapy-to-inhibit-vein-graft-events-randomized-controlled-trial-nct01528709
#13
Alexander Kulik, Amy M Abreu, Viviana Boronat, Marc Ruel
RATIONALE: Saphenous vein graft disease remains a major limitation of coronary artery bypass graft surgery (CABG). Statin therapy inhibits the development of vein graft disease and improves outcomes after CABG. However, it is unclear whether treatment with high-dose statins will further slow the process of vein graft disease and improve graft patency, as compared to conventional moderate doses. Therefore, the goal of this study will be to evaluate the efficacy of high-dose statin therapy versus moderate-dose statin therapy for the prevention of saphenous vein graft occlusion following CABG...
June 10, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28610970/internal-maxillary-artery-bypass-with-radial-artery-graft-treatment-of-giant-intracranial-aneurysms
#14
Long Wang, Shuaibin Lu, Hai Qian, Xiang'en Shi
BACKGROUND: Giant intracranial aneurysms (GIAs) can be approached via microsurgical and endovascular techniques. Utilization of flow diversion devices (FDDs) has yielded favorable outcomes, and indications for cerebral revascularization have dramatically decreased. OBJECTIVE: To evaluate the safety and validity of using internal maxillary artery (IMA) bypass with an interposed graft to treat GIAs. METHODS: During a 6-year period, high-flow IMA bypass procedures were performed in 32 patients with GIAs at our institute...
June 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28606278/-efficacy-of-mitral-valve-repair-versus-replacement-in-severe-ischemic-mitral-regurgitation
#15
Z B Qiu, X Chen, M Xu, Y S Jiang, L M Wang, F H Huang, P S Liu, R Wang, F Xiang, J J Shao, W Qin
Objective: To compare the mortality, survival rate and the therapeutic efficacy between mitral valve repair and replacement as treatment for severe ischemic mitral regurgitation (IMR), and explore the middle- and long-term outcomes. Methods: Between January 2000 and January 2016, 378 patients with severe IMR underwent coronary artery bypass grafting (CABG) combined with mitral valve repair (n=162) or mitral valve replacement (n=216) in the Department of Cardiovascular Surgery of Nanjing First Hospital. Clinical data, in-hospital morbidity and mortality of patients were retrospectively reviewed...
June 13, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28605930/central-retinal-vein-occlusion-after-coronary-artery-bypass-surgery-a-case-report
#16
Ufuk Ciloglu, Mustafa Aldag, Sebnem Albeyoglu, Veysel Aykut, Canan Karakaya, Burcu Gonul
OBJECTIVE: The aim of this study is to report a case of central retinal vein occlusion (CRVO) after coronary artery bypass graft (CABG) surgery. In this report, we present the third case in the literature with CRVO after cardiopulmonary bypass (CPB), and the first case after CABG. CASE REPORT: A 59-year-old male patient complaining of chest pain was admitted to our hospital. The patient underwent an elective coronary angiography and was diagnosed with three-vessel coronary artery disease...
May 2017: Acta Medica Academica
https://www.readbyqxmd.com/read/28603012/an-improved-three-vessel-occlusion-model-of-global-cerebral-ischemia-in-rats
#17
Dmitriy N Atochin, Galina A Chernysheva, Oleg I Aliev, Vera I Smolyakova, Anton N Osipenko, Sergey V Logvinov, Anna A Zhdankina, Tatiana M Plotnikova, Mark B Plotnikov
We developed an improved three-vessel occlusion model of global cerebral ischemia in rats. This method consists in cessation of cerebral blood flow by accessing a. carotis communis sinistra through the ventral surface of the neck as well as tr. brachiocephalicus and a. subclavia sinistra through the first intercostal space, bypassing the pleural cavity and excluding pneumothorax. After the occlusion of the vessels that resulted in interruption of their blood flow, according to laser-Doppler flowmetry, there was a sharp decline in local cerebral blood flow in the visual cortex to 4±1% of the initial level...
June 8, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28602580/a-comparison-of-outcomes-in-patients-with-infrapopliteal-disease-randomised-to-vein-bypass-or-plain-balloon-angioplasty-in-the-bypass-vs-angioplasty-in-severe-ischaemia-of-the-leg-basil-trial
#18
M A Popplewell, H O B Davies, J Narayanswami, M Renton, A Sharp, G Bate, S Patel, J Deeks, A W Bradbury
OBJECTIVE: The aim was to compare outcomes in a subgroup of patients with infrapopliteal (IP) disease randomised to infrapopliteal vein bypass (VB) or plain balloon angioplasty (PBA) in the original BASIL trial. METHODS: A comparison of outcomes from patients randomised to VB or PBA undergoing revascularisation for severe limb ischaemia (SLI) because of IP disease with or without femoropopliteal disease. Data were extracted from case report forms from the BASIL trial...
June 8, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28602219/tranexamic-acid-leads-to-paradoxical-coagulation-changes-during-cardiac-surgery-a-pilot-rotational-thromboelastometry-study
#19
Rajiv Sharma, Hayley L Letson, Samuel Smith, Geoffrey P Dobson
BACKGROUND: Tranexamic acid (TXA) is increasingly used during major surgery with the goal to reduce excessive bleeding, transfusion requirements, and reexploration. Our aim was to examine the effect of TXA on coagulation at different times during cardiac surgery using rotational thromboelastometry. MATERIALS AND METHODS: Nineteen adult males (EuroSCORE 4-5) were recruited consecutively for first-time cardiopulmonary bypass (CPB) surgery. Ten patients received TXA at anesthesia and nine received no TXA...
May 8, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28600750/intra-operative-hemorrhage-due-to-hyperperfusion-during-direct-revascularization-surgery-in-an-adult-patient-with-moyamoya-disease-a-case-report
#20
Hiroki Uchida, Hidenori Endo, Miki Fujimura, Toshiki Endo, Kuniyasu Niizuma, Teiji Tominaga
Hemorrhagic complication is one of the notable surgical complications of the revascularization surgery for moyamoya disease (MMD). Cerebral hyperperfusion (CHP) has been considered as the underlying cause of this complication. It mostly occurs several days after surgery, but the intra-operative hemorrhage immediately after bypass has not been reported previously. A 21-year-old woman presented right thalamic hemorrhage and was diagnosed as having MMD by cerebral angiography. In light of the location of the hemorrhage at the vascular territory of posterior circulation and the manifestation of transient ischemic attack during the follow-up period, she underwent revascularization surgery to prevent future ischemic attack and rebleeding...
June 9, 2017: Neurosurgical Review
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