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https://www.readbyqxmd.com/read/28810604/hard-clam-extracts-induce-atypical-apoptosis-in-human-gastric-cancer-cells
#1
Eing-Ju Song, Michael W Y Chan, Jyh-Wei Shin, Che-Chun Chen
Hard clams (HCs) are a nutritionally high-quality and popular seafood, and are established to be a potent antitumor food. The aim of the present study was to determine whether HC extracts induce apoptosis in the human gastric cancer cell line, AGS. In contrast with previously reported methods of extraction, crude extracts of HC were obtained by freezing and thawing and by a method free of hot water or organic solvents. The composition, quality and properties of the HC extracts were demonstrated to be stable since the extracts that were evaluated by capillary electrophoresis and HPLC analysis at different timepoints were similar...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28808503/prognostic-efficacy-of-inflammation-based-markers-in-patients-with-curative-colorectal-cancer-resection
#2
Özgür Akgül, Erdinç Çetinkaya, Metin Yalaza, Sabri Özden, Mesut Tez
AIM: To evaluate the prognostic significance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and prognostic nutritional index (PNI) and other clinicopathological factors in patients undergoing curative resection of colon cancer. METHODS: 183 patients with histologically proven colorectal cancer who had undergone potentially curative resection between 2010 and 2016 at Ankara Numune Training and Research Hospital were retrospectively analyzed and clinicopathological characteristics included age, sex, tumor type, grade, size and localization, the number of metastatic and total number of lymph nodes removed, vascular and perineural invasion of the tumor, TNM stages, tumor marker levels (CEA, CA19-9, AFP, CA-125, CA15-3), complete blood counts, albumin levels, overall survival (months), NLR, PLR, LMR and PNI ratios were retrospectively reviewed and analyzed from the electronic database...
July 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28808093/are-disagreements-in-caregiver-and-patient-assessment-of-patient-health-associated-with-increased-caregiver-burden-in-caregivers-of-older-adults-with-cancer
#3
Tina Hsu, Matthew Loscalzo, Rupal Ramani, Stephen Forman, Leslie Popplewell, Karen Clark, Vani Katheria, Rex Strowbridge, Redmond Rinehart, Dan Smith, Keith Matthews, Jeff Dillehunt, Tao Feng, David Smith, Canlan Sun, Arti Hurria
BACKGROUND: As patients age, caregivers increasingly provide essential support and patient information. We sought to determine if patient-caregiver assessments of patient health differ and if differences contribute to burden in caregivers of older adults with cancer. MATERIALS AND METHODS: One hundred patients, aged ≥65, and their caregivers independently assessed patient function, comorbidity, nutrition, social activity, social support, and mental health. Caregivers completed the Caregiver Strain Index (CSI)...
August 14, 2017: Oncologist
https://www.readbyqxmd.com/read/28807074/a-model-to-predict-central-line-associated-bloodstream-infection-among-patients-with-peripherally-inserted-central-catheters-the-mpc-score
#4
Erica Herc, Payal Patel, Laraine L Washer, Anna Conlon, Scott A Flanders, Vineet Chopra
BACKGROUND Peripherally inserted central catheters (PICCs) are associated with central-line-associated bloodstream infections (CLABSIs). However, no tools to predict risk of PICC-CLABSI have been developed. OBJECTIVE To operationalize or prioritize CLABSI risk factors when making decisions regarding the use of PICCs using a risk model to estimate an individual's risk of PICC-CLABSI prior to device placement. METHODS Using data from the Michigan Hospital Medicine Safety consortium, patients that experienced PICC-CLABSI between January 2013 and October 2016 were identified...
August 15, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28806753/accelerometer-derived-physical-activity-and-sedentary-time-by-cancer-type-in-the-united-states
#5
Keith M Thraen-Borowski, Keith P Gennuso, Lisa Cadmus-Bertram
The 2003-2004 and 2005-2006 cycles of the National Health and Nutrition Examination Survey (NHANES) were among the first population-level studies to incorporate objectively measured physical activity and sedentary behavior, allowing for greater understanding of these behaviors. However, there has yet to be a comprehensive examination of these data in cancer survivors, including short- and long-term survivors of all cancer types. Therefore, the purpose of this analysis was to use these data to describe activity behaviors in short- and long-term cancer survivors of various types...
2017: PloS One
https://www.readbyqxmd.com/read/28805667/the-effect-of-a-standardized-ginger-extract-on-chemotherapy-induced-nausea-related-quality-of-life-in-patients-undergoing-moderately-or-highly-emetogenic-chemotherapy-a-double-blind-randomized-placebo-controlled-trial
#6
Wolfgang Marx, Alexandra L McCarthy, Karin Ried, Dan McKavanagh, Luis Vitetta, Avni Sali, Anna Lohning, Elisabeth Isenring
Ginger supplementation could be an effective adjuvant treatment for chemotherapy-induced nausea (CIN). The aim of this clinical trial was to address significant methodological limitations in previous trials. Patients (N = 51) were randomly allocated to receive either 1.2 g of standardised ginger extract or placebo per day, in addition to standard anti-emetic therapy, during the first three cycles of chemotherapy. The primary outcome was CIN-related quality of life (QoL) measured with the Functional Living Index- Emesis (FLIE) questionnaire...
August 12, 2017: Nutrients
https://www.readbyqxmd.com/read/28804801/pancreatic-enzyme-supplementation-after-gastrectomy-for-gastric-cancer-a-randomized-controlled-trial
#7
Marco Catarci, Manuele Berlanda, Giovanni Battista Grassi, Francesco Masedu, Stefano Guadagni
BACKGROUND: Gastrectomy for gastric cancer is a significant cause of secondary exocrine pancreatic insufficiency. Pancreatic enzyme replacement therapy may influence nutritional status and quality of life after gastrectomy, but the pertinent clinical research to date remains controversial. A randomized controlled trial to test this hypothesis was carried out. METHODS: After gastrectomy, 43 patients with gastric cancer were randomly assigned to a normal diet (Normal-d; n = 21) or to a pancreatic enzyme supplementation diet (PES-d; n = 22) and were followed up during a 12-month period, assessing nutritional status and quality of life through body mass index (BMI), instant nutritional assessment (INA) class status, serum pre-albumin (SPA) values, and GastroiIntestinal Quality of Life Index (GIQLI)...
August 14, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28803460/-gastrostomy-tubes-indications-and-infectious-complications-in-a-tertiary-hospital
#8
M J Muñoz-Dávila, J M Xandri Ruipera, G Yagüe Guirao, C Salvador García, M Segovia Hernández
OBJECTIVE: Gastrostomy tube is the best option for long-term enteral nutrition. Among its limitations, infections represent the most frequent minor complication. Our aim is the knowledge of the number and type of gastrostomy tubes and its main indication in our hospital. In addition, prevalence of infectious complications was studied paying attention to the main etiologic agents and their antibiotic susceptibility. METHODS: Observational retrospective study from January 2010 to July 2015 through the electronic clinical history and the clinical microbiology laboratory software...
August 14, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28802289/home-enteral-nutrition-s-effects-on-nutritional-status-and-quality-of-life-after-esophagectomy
#9
Jian Zeng, Jian Hu, Qixun Chen, Jianguo Feng
BACKGROUND AND OBJECTIVES: We aimed to characterize the effect of home enteral nutrition (HEN) on the nutritional status and the quality of life (QOL) of esophageal cancer patients who underwent Ivor Lewis esophagectomy for cancer. METHODS AND STUDY DESIGN: Sixty patients with esophageal cancer were assigned to receive either HEN (n=30) or standard care only (n=30) from 1 week to 24 weeks following surgery. Nutritional status was evaluated using The Mini Nutritional Assessment at 1 week preoperatively and at 12 and 24 weeks postoperatively...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28802169/human-health-risk-assessment-on-the-consumption-of-fruits-and-vegetables-containing-residual-pesticides-a-cancer-and-non-cancer-risk-benefit-perspective
#10
Mathieu Valcke, Marie-Hélène Bourgault, Louis Rochette, Louise Normandin, Onil Samuel, Denis Belleville, Carole Blanchet, Denise Phaneuf
Pesticide residues in food is a public health concern. This study aimed to evaluate health risk and benefit associated with chronic consumption of fruits and vegetables (F&V) containing residual pesticides in the province of Quebec, Canada. Based on a representative sample of Quebecers (n=4727, aged 1-79) enrolled in the Canadian nutrition survey, population's mean chronic dietary exposure through consumption of F&V was evaluated for 169 different pesticide active ingredients (PAI), including 135 for which toxicological reference values (TRV) were available in the literature...
August 9, 2017: Environment International
https://www.readbyqxmd.com/read/28800318/mir-513c-suppresses-neuroblastoma-cell-migration-invasion-and-proliferation-through-direct-targeting-glutaminase-gls
#11
Hong-Liang Xia, Yao Lv, Chun-Wei Xu, Ming-Cui Fu, Ting Zhang, Xiang-Ming Yan, Shu Dai, Qian-Wei Xiong, Yun Zhou, Jian Wang, Xu Cao
Neuroblastoma is a brain malignancy of childhood and accounts for 7-10% of childhood cancers, leading to approximately 15% of pediatric cancer deaths. MicroRNAs (miRNAs) are a family of short (about 18-25 nucleotides), noncoding and single stranded endogenous RNAs, which complementarily bind to the 3' untranslated regions of their target genes. Recently, glutamine metabolism has been recognized as an important nutrition source for tumor cells, and hence targeting glutamine metabolism could benefit to development of anti-cancer agents...
July 2, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28797450/tube-feeding-during-treatment-for-head-and-neck-cancer-adherence-and-patient-reported-barriers
#12
Teresa Brown, Merrilyn Banks, Brett G M Hughes, Charles Lin, Lizbeth Kenny, Judith Bauer
OBJECTIVES: The main aim was to investigate the incidence of patient adherence to nutritional tube feeding recommendations in patients with head and neck cancer and to determine patient barriers to meeting tube feeding prescription. MATERIALS AND METHODS: This was an observational study from a randomised controlled trial in patients with head and neck cancer deemed at high nutritional risk with prophylactic gastrostomy (n=125). Patients were randomised to receive early tube feeding prior to treatment (intervention group) or standard care...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797119/a-retrospective-study-of-606-cases-of-nasopharyngeal-carcinoma-with-or-without-oropharyngeal-candidiasis-during-radiotherapy
#13
Wen-Ze Qiu, Liang-Ru Ke, Wei-Xiong Xia, Jing Yang, Ya-Hui Yu, Hu Liang, Xin-Jun Huang, Guo-Ying Liu, Wang-Zhong Li, Yan-Qun Xiang, Xiang Guo, Xing Lv
BACKGROUND: To evaluate the clinical characteristics, treatment-related toxicities and survival in patients with nasopharyngeal carcinoma (NPC) with or without oropharyngealcandidiasis (OPC) during radiotherapy. METHODS: The current study was conducted with NPC patients undergoing radiotherapy at Sun Yat-Sen University Cancer Center between June 2011 and May 2012. A clinical diagnosis of candidiasis was determined on the basis of a positive potassium hydroxide (KOH) test and the presence of pseudomembranous (white) form of candidal overgrowth...
2017: PloS One
https://www.readbyqxmd.com/read/28796289/medicine-is-not-health-care-food-is-health-care-plant-metabolic-engineering-diet-and-human-health
#14
REVIEW
Cathie Martin, Jie Li
Contents I. II. III. IV. V. VI. References SUMMARY: Plants make substantial contributions to our health through our diets, providing macronutrients for energy and growth as well as essential vitamins and phytonutrients that protect us from chronic diseases. Imbalances in our food can lead to deficiency diseases or obesity and associated metabolic disorders, increased risk of cardiovascular diseases and cancer. Nutritional security is now a global challenge which can be addressed, at least in part, through plant metabolic engineering for nutritional improvement of foods that are accessible to and eaten by many...
August 10, 2017: New Phytologist
https://www.readbyqxmd.com/read/28795875/animal-models-for-studying-epithelial-barriers-in-neonatal-necrotizing-enterocolitis-inflammatory-bowel-disease-and-colorectal-cancer
#15
Tiaosi Xing, Rolando Camacho Salazar, Yan-Hua Chen
The intestinal epithelial cells line the luminal surface of the entire gastrointestinal tract which is crucial for the absorption of nutrients and prevention of pathogens entering from the external environment. The epithelial barrier plays an important role in organ development, disease pathogenesis, and aging. The major component of an epithelial barrier is the single columnar epithelium and tight junctions. Tight junctions are located at the most apical region of the junctional complex and contain many integral membrane proteins, such as occludin, the claudin family, and junctional adhesion molecules (JAMs)...
July 20, 2017: Tissue Barriers
https://www.readbyqxmd.com/read/28795218/atopy-and-prostate-cancer-is-there-a-link-between-circulating-levels-of-ige-and-psa-in-humans
#16
Mieke Van Hemelrijck, Sophia N Karagiannis, Sabine Rohrmann
BACKGROUND: Atopy has been investigated as a potential risk factor for prostate cancer. IgE antibodies may be major players in protective responses against tumours, through engendering antigen presentation and enhancing adaptive immune responses targeted towards a specific allergen, but potentially also against tumour-associated antigens such as prostate-specific antigen (PSA). We therefore cross-sectionally investigated associations between circulating levels of PSA and IgE in the National Health and Nutrition Examination Survey 2005-2006...
August 9, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28793905/the-liverpool-care-pathway-a-systematic-review-discarded-in-cancer-patients-but-good-enough-for-dying-nursing-home-patients
#17
Bettina S Husebø, Elisabeth Flo, Knut Engedal
BACKGROUND: The Liverpool Care Pathway (LCP) is an interdisciplinary protocol, aiming to ensure that dying patients receive dignified and individualized treatment and care at the end-of-life. LCP was originally developed in 1997 in the United Kingdom from a model of cancer care successfully established in hospices. It has since been introduced in many countries, including Norway. The method was withdrawn in the UK in 2013. This review investigates whether LCP has been adapted and validated for use in nursing homes and for dying people with dementia...
August 9, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28793755/cancer-screening-rate-in-diabetic-patients-in-the-korean-population-results-from-korean-national-health-and-nutrition-examination-survey-knhanes-2007-2009
#18
Kumban Walter Chuck, Minji Hwang, Kui Son Choi, Mina Suh, Jae Kwan Jun, Boyoung Park
Purpose: To investigate the screening rate for gastric, breast, and cervical cancer in people with diabetes compared with people without diabetes. Methods: Data from the Korean National Health and Nutrition Examination survey 2007-2009 was used. Cancer-free men who were 40 years old and over and women who were 30 years old and over were included. Lifetime screening rate and regular screening rate were compared in people with and without diabetes. Results: People with diabetes received less cancer screening than people without diabetes in their lifetime (53...
August 10, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28792413/human-reproduction-and-health-an-evolutionary-perspective
#19
REVIEW
Grazyna Jasienska, Richard G Bribiescas, Anne-Sofie Furberg, Samuli Helle, Alejandra Núñez-de la Mora
According to life history theory, increased investment in reproductive function (physiology and behaviour) at different times throughout the life course affects the risk of many diseases and, ultimately, longevity. Although genetic factors contribute to interindividual and interpopulation variation in reproductive traits, the dominant source of variability is phenotypic plasticity during development and adult life. Reproductive traits in both sexes evolved sensitivity to ecological conditions, as reflected in contemporary associations of hormone concentrations with geographical setting, nutritional status, and physical activity level...
July 29, 2017: Lancet
https://www.readbyqxmd.com/read/28792014/applicability-of-the-direct-parameters-of-bioelectrical-impedance-in-assessing-nutritional-status-and-surgical-complications-of-women-with-gynecological-cancer
#20
I C R Cardoso, M A Aredes, G V Chaves
BACKGROUND/OBJECTIVES: Bioelectrical impedance vector analysis (BIVA) has been considered a promising technique in monitoring the nutritional and hydration status of patients with different types of diseases. The aim of this study was to assess the nutritional status provided by direct parameters of bioelectrical impedance analysis (BIA), BIVA and phase angle (PA), in patients with cervical and endometrial cancer undergoing surgical treatment, associating to other parameters of nutritional status and surgical outcomes...
August 9, 2017: European Journal of Clinical Nutrition
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