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Marcel van vugt ATR oncogene

Ivan Mamely, Marcel Atm van Vugt, Veronique A J Smits, Jennifer I Semple, Bennie Lemmens, Anastassis Perrakis, René H Medema, Raimundo Freire
DNA-damage checkpoints maintain genomic integrity by mediating a cell-cycle delay in response to genotoxic stress or stalled replication forks. In response to damage, the checkpoint kinase ATR phosphorylates and activates its effector kinase Chk1 in a process that critically depends on Claspin . However, it is not known how exactly this kinase cascade is silenced. Here we demonstrate that the abundance of Claspin is regulated through proteasomal degradation. In response to DNA damage, Claspin is transiently stabilized, and its expression depends on Chk1 kinase activity...
October 10, 2006: Current Biology: CB
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