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Long term follow up post blood and marrow transplant

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https://www.readbyqxmd.com/read/27821187/long-term-survival-and-late-events-after-allogeneic-stem-cell-transplantation-from-hla-matched-siblings-for-acute-myeloid-leukemia-with-myeloablative-compared-to-reduced-intensity-conditioning-a-report-on-behalf-of-the-acute-leukemia-working-party-of-european
#1
Avichai Shimoni, Myriam Labopin, Bipin Savani, Liisa Volin, Gerhard Ehninger, Jurgen Kuball, Donald Bunjes, Nicolaas Schaap, Stephane Vigouroux, Andrea Bacigalupo, Hendrik Veelken, Jorge Sierra, Matthias Eder, Dietger Niederwieser, Mohamad Mohty, Arnon Nagler
BACKGROUND: Myeloablative (MAC) and reduced-intensity conditioning (RIC) are established approaches for allogeneic stem cell transplantation (SCT) in acute myeloid leukemia (AML). Most deaths after MAC occur within the first 2 years after SCT, while patients surviving leukemia-free for 2 years can expect a favorable long-term outcome. However, there is paucity of data on the long-term outcome (beyond 10 years) and the pattern of late events following RIC due to the relative recent introduction of this approach...
November 8, 2016: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27264632/late-effects-after-umbilical-cord-blood-transplantation-in-very-young-children-after-busulfan-based-myeloablative-conditioning
#2
Heather Allewelt, Jill El-Khorazaty, Adam Mendizabal, Mahsa Taskindoust, Paul L Martin, Vinod Prasad, Kristin Page, Jean Sanders, Joanne Kurtzberg
Infants and young children who undergo allogeneic cord blood transplantation (CBT) are at increased risk for late effects because of exposure of developing organs to chemotherapy and radiation therapy typically used in transplant conditioning regimens. Busulfan (Bu)-based myeloablative regimens were developed to eliminate radiation exposure in these young children with the hope that late effects would be minimized. We now describe the late effects in 102 consecutive patients surviving a minimum of 5 years (median follow-up, 12...
September 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27164064/long-term-follow-up-after-reduced-intensity-conditioning-and-stem-cell-transplantation-for-childhood-nonmalignant-disorders
#3
Lisa M Madden, Robert J Hayashi, Ka Wah Chan, Michael A Pulsipher, Dorothea Douglas, Gregory A Hale, Sonali Chaudhury, Paul Haut, Kimberly A Kasow, Andrew L Gilman, Lisa M Murray, Shalini Shenoy
Reduced-intensity conditioning (RIC) before hematopoietic stem cell transplantation (HCT) in children could result in fewer complications during follow-up compared with myeloablative regimens. Hence, many RIC regimens are under investigation, but long-term follow-up is essential. We describe late follow-up beyond 2 years post-HCT in 43 children with nonmalignant disorders who underwent related or unrelated donor (56%) HCT on a multicenter study using a RIC regimen (alemtuzumab, fludarabine, and melphalan) followed by bone marrow (n = 30), peripheral blood (n = 3), or umbilical cord blood (n = 10) HCT for immune dysfunction, bone marrow failure, metabolic disorders, or hemoglobinopathy...
August 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27000734/autologous-stem-cell-transplantation-versus-alternative-allogeneic-donor-transplants-in-adult-acute-leukemias
#4
REVIEW
Norbert Claude Gorin
The availability of alternative sources of stem cells including most recently T-replete haploidentical marrow or peripheral blood, and the increasing use of reduced-intensity conditioning (RIC), renders feasible an allogeneic transplant to almost all patients with acute leukemia up to 70 years of age. Autologous stem cell transplantation (ASCT) for consolidation of complete remission (CR), however, offers in some circumstances an alternative option. Although associated with a higher relapse rate, autologous transplant benefits from a lower non-relapse mortality, the absence of graft-versus-host disease (GVHD), and a better quality of life for long-term survivors...
April 2016: Seminars in Hematology
https://www.readbyqxmd.com/read/26746819/what-they-want-inclusion-of-blood-and-marrow-transplanation-survivor-preference-in-the-development-of-models-of-care-for-long-term-health-in-sydney-australia
#5
Gemma Dyer, Nicole Gilroy, Louisa Brown, Megan Hogg, Lisa Brice, Masura Kabir, Matt Greenwood, Stephen R Larsen, John Moore, Mark Hertzberg, John Kwan, Gillian Huang, Jeff Tan, Christopher Ward, Ian Kerridge
Four hundred forty-one adult allogeneic blood and marrow transplantation (BMT) survivors participated in a cross-sectional survey to assess long-term follow-up (LTFU) model of care preference. Survey instruments included the Sydney Post BMT Survey, Functional Assessment of Cancer Therapy-BMT, Depression Anxiety Stress Scales 21, the Chronic GVHD Activity Assessment-Patient Self Report (Form B), the Lee Chronic GVHD Symptom Scale and the Post-Traumatic Growth Inventory. We found most BMT survivors (74%) would prefer LTFU with their transplantation physicians alone or in combination with transplantation center-linked services (satellite clinics or telemedicine) Over one-quarter indicated a preference for receiving comprehensive post-transplantation care in a "satellite" clinic staffed by their BMT team situated closer to their place of residence, with higher income, higher educational level, and sexual morbidity being significant social factors influencing this preference...
April 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/26291959/hematopoietic-stem-cell-transplantation-for-cd40-ligand-deficiency-single-institution-experience
#6
Heather Allewelt, Paul L Martin, Paul Szabolcs, Nelson Chao, Rebecca Buckley, Suhag Parikh
BACKGROUND: X-linked hyper-IgM syndrome (X-HIGM) due to mutations in the gene encoding CD40 ligand results in failure of Ig class switching and an increased propensity for recurrent sinopulmonary and other infections, and thus decreased life expectancy. Allogeneic hematopoietic stem cell transplantation (HSCT) is curative, but long-term follow-up data are limited. PROCEDURES: We conducted a retrospective analysis of seven patients who have undergone allogeneic HSCT for HIGM syndrome at Duke University Medical Center...
December 2015: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/24999225/lost-in-transition-the-essential-need-for-long-term-follow-up-clinic-for-blood-and-marrow-transplantation-survivors
#7
REVIEW
Shahrukh Hashmi, Paul Carpenter, Nandita Khera, André Tichelli, Bipin N Savani
Because of expanding indications and improvements in supportive care, the utilization of blood and marrow cell transplantation (BMT) to treat various conditions is increasing exponentially, and currently more than 60,000 BMTs are performed annually worldwide. By the year 2030, it is projected that the number of BMT survivors will increase 5-fold, potentially resulting in one half of a million survivors in the United States alone. As the majority of survivors now live beyond the first 2 years after BMT, they are prone to a unique set of complications and late effects...
February 2015: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/24464145/long-term-outcome-of-hla-haploidentical-hematopoietic-sct-without-in-vitro-t-cell-depletion-for-adult-severe-aplastic-anemia-after-modified-conditioning-and-supportive-therapy
#8
L Gao, Y Li, Y Zhang, X Chen, L Gao, C Zhang, Y Liu, P Kong, Q Wang, Y Su, C Wang, S Wang, B Li, A Sun, X Du, D Zeng, J Li, H Liu, X Zhang
HLA-haploidentical hematopoietic SCT (HSCT) is an option for severe aplastic anemia (SAA) patients. Here, we evaluated the outcomes of 26 adult-SAA patients who received HLA-haploidentical HSCT in five transplant centers in southwestern China. Most of the patients in this study failed prior therapy and were transfused heavily before the transplantation. The patients received fludarabine+cyclophosphamide+antithymocyte globulin as conditioning regimens and then unmanipulated peripheral blood plus marrow transplantation...
April 2014: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/24441288/long-term-follow-up-of-imatinib-in-pediatric-philadelphia-chromosome-positive-acute-lymphoblastic-leukemia-children-s-oncology-group-study-aall0031
#9
K R Schultz, A Carroll, N A Heerema, W P Bowman, A Aledo, W B Slayton, H Sather, M Devidas, H W Zheng, S M Davies, P S Gaynon, M Trigg, R Rutledge, D Jorstad, N Winick, M J Borowitz, S P Hunger, W L Carroll, B Camitta
We previously reported preliminary findings that post induction imatinib mesylate (340 mg/m(2)/day), in combination with intensive chemotherapy, resulted in outcomes similar to blood and marrow transplant (BMT) for pediatric patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). We now report 5-year outcomes of imatinib plus intensive chemotherapy in 91 children (1-21 years) with and without allogeneic BMT (N=91). We explore the impacts of additional chromosomal abnormalities and minimal residual disease (MRD) by flow cytometry on outcomes...
July 2014: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/24389309/allogeneic-hematopoietic-stem-cell-transplantation-in-patients-with-polycythemia-vera-or-essential-thrombocythemia-transformed-to-myelofibrosis-or-acute-myeloid-leukemia-a-report-from-the-mpn-subcommittee-of-the-chronic-malignancies-working-party-of-the-european
#10
Federico Lussana, Alessandro Rambaldi, Maria Chiara Finazzi, Anja van Biezen, Marijke Scholten, Elena Oldani, Alessandra Carobbio, Simona Iacobelli, Jurgen Finke, Arnon Nagler, Liisa Volin, Thierry Lamy, Renate Arnold, Mohamad Mohty, Mauricette Michallet, Theo de Witte, Eduardo Olavarria, Nicolaus Kröger
The clinical course of polycythemia vera and essential thrombocythemia is potentially associated with long-term severe complications, such as evolution to myelofibrosis or acute myeloid leukemia. Allogeneic stem cell transplantation is currently the only potentially curative treatment for advanced polycythemia vera or essential thrombocythemia. We analyzed 250 consecutive patients with an initial diagnosis of polycythemia vera (n=120) or essential thrombocythemia (n=130), who underwent transplantation due to progression to myelofibrosis (n=193) or acute myeloid leukemia (n=57) and who were reported to the European Group for Blood and Marrow Transplantation registry between 1994 and 2010...
May 2014: Haematologica
https://www.readbyqxmd.com/read/24141008/improved-survival-with-ursodeoxycholic-acid-prophylaxis-in-allogeneic-stem-cell-transplantation-long-term-follow-up-of-a-randomized-study
#11
Tapani Ruutu, Eeva Juvonen, Mats Remberger, Kari Remes, Liisa Volin, Jonas Mattsson, Anne Nihtinen, Hans Hägglund, Olle Ringdén
We report the long-term results of a prospective randomized study on the use of ursodeoxycholic acid (UDCA) for prevention of hepatic complications after allogeneic stem cell transplantation. Two hundred forty-two patients, 232 with malignant disease, were randomized to receive (n = 123) or not to receive (n = 119) UDCA from the beginning of the conditioning until 90 days post-transplantation. The results were reported after 1-year follow-up. UDCA administration reduced significantly the proportion of patients developing high serum bilirubin levels as well as the incidence of severe acute graft-versus-host disease (GVHD), liver GVHD, and intestinal GVHD...
January 2014: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/24038022/loss-of-quiescence-and-impaired-function-of-cd34-cd38-low-cells-one-year-following-autologous-stem-cell-transplantation
#12
Carolien M Woolthuis, Annet Z Brouwers-Vos, Gerwin Huls, Joost Th M de Wolf, Jan Jacob Schuringa, Edo Vellenga
Patients who have undergone autologous stem cell transplantation are subsequently more susceptible to chemotherapy-induced bone marrow toxicity. In the present study, bone marrow primitive progenitor cells were examined one year after autologous stem cell transplantation and compared with normal bone marrow and mobilized peripheral blood stem cells. Post-transplantation bone marrow contained a significantly lower percentage of quiescent cells in the CD34(+)/CD38(low) fraction compared to normal bone marrow...
December 2013: Haematologica
https://www.readbyqxmd.com/read/23727584/detection-of-minimal-residual-disease-in-patients-with-multiple-myeloma-using-clonotype-specific-pcr-primers-designed-from-dna-extracted-from-archival-bone-marrow-slides
#13
Hiroyuki Takamatsu, Yoshiyasu Ogawa, Noriko Kobayashi, Kazue Obata, Tadashi Narisawa, Kouji Nakayama, Saori Munemoto, Go Aoki, Kinya Ohata, Yoshihisa Kumano, Jun Ozaki, Ryoichi Murata, Yukio Kondo, Yasushi Terasaki, Toshiro Kurokawa, Toshihiro Miyamoto, Naomi Shimizu, Toshihiro Fukushima, Akira Yoshida, Takanori Ueda, Takashi Yoshida, Shinji Nakao
Polymerase chain reaction (PCR)-negative molecular complete remission (mCR) can be induced by stem cell transplantation in some patients with multiple myeloma (MM) and is associated with long-term progression-free survival (PFS). The detection of molecular minimal residual disease (MRD), however, requires fresh or frozen materials for designing clone-specific primers, which are not always readily available. In this study, we used DNA extracted from archival bone marrow (BM) slides for PCR to detect MRD in 50 patients with MM who received various induction therapies and autologous peripheral blood stem cell transplantation (ASCT)...
October 2013: Experimental Hematology
https://www.readbyqxmd.com/read/23257404/autologous-haematopoietic-stem-cell-transplantation-for-systemic-lupus-erythematosus-data-from-the-european-group-for-blood-and-marrow-transplantation-registry
#14
B Alchi, D Jayne, M Labopin, Alexander Demin, V Sergeevicheva, T Alexander, F Gualandi, B Gruhn, J Ouyang, P Rzepecki, G Held, A Sampol, J Voswinkel, P Ljungman, A Fassas, M Badoglio, R Saccardi, D Farge
OBJECTIVES: Patients with systemic lupus erythematosus (SLE) refractory to conventional immunosuppression suffer substantial morbidity and mortality due to active disease and treatment toxicity. Immunoablation followed by autologous stem cell transplantation (ASCT) is a novel therapeutic strategy that potentially offers new hope to these patients. METHODS: This retrospective survey reviews the efficacy and safety of ASCT in 28 SLE patients from eight centres reported to the European Group for Blood and Marrow Transplantation (EBMT) registry between 2001 and 2008...
March 2013: Lupus
https://www.readbyqxmd.com/read/23206842/haploidentical-bone-marrow-transplantation-without-t-cell-depletion
#15
REVIEW
Ying-Jun Chang, Xiao-Jun Huang
Approaches for haploidentical bone marrow transplantation (BMT) without T-cell depletion have been designed using new transplant strategies, including anti-thymocyte globulin (ATG) preparative regimens, granulocyte colony-stimulating factor-primed grafts, post-transplantation rapamycin, or high-dose cyclophosphamide (Cy) in combination with other immunosuppressive agents for graft-versus-host disease (GVHD) prophylaxis. These strategies ensured fast hematologic engraftment across the human leukocyte antigen (HLA) barrier with an acceptable incidence of GVHD...
December 2012: Seminars in Oncology
https://www.readbyqxmd.com/read/23151215/late-relapses-following-reduced-intensity-allogeneic-transplantation-in-patients-with-multiple-myeloma-a-long-term-follow-up-study
#16
Firoozeh Sahebi, Yan Shen, Sandra H Thomas, Amalia Rincon, Joyce Murata-Collins, Joycelynne Palmer, Amrita Y Krishnan, Chatchada Karanes, Myo Htut, George Somlo, Stephen J Forman
We analysed the long-term outcomes of 60 multiple myeloma patients who underwent reduced intensity allogeneic stem cell transplantation between August 2000 and March 2008. Regimens included fludarabine and melphalan conditioning (flu-mel regimen) for allogeneic haematopoietic cell transplant (HCT) or a planned tandem regimen consisting of high-dose melphalan conditioning for autograft followed by low-dose total body irradiation conditioning for allogeneic HCT (auto-allo regimen). Donors included human-leucocyte-antigen-matched siblings (n = 55) or matched unrelated donors (n = 5)...
January 2013: British Journal of Haematology
https://www.readbyqxmd.com/read/23084475/reduced-toxicity-with-intensity-modulated-radiation-therapy-imrt-for-desmoplastic-small-round-cell-tumor-dsrct-an-update-on-the-whole-abdominopelvic-radiation-therapy-wap-rt-experience
#17
COMPARATIVE STUDY
Neil B Desai, Nicholas F Stein, Michael P LaQuaglia, Kaled M Alektiar, Brian H Kushner, Shakeel Modak, Heather M Magnan, Karyn Goodman, Suzanne L Wolden
PURPOSE: Desmoplastic small round cell tumor (DSRCT) is a rare malignancy typically involving the peritoneum in young men. Whole abdominopelvic radiation therapy (WAP-RT) using conventional 2-dimensional (2D) radiation therapy (RT) is used to address local recurrence but has been limited by toxicity. Our objectives were to assess the benefit of intensity modulated radiation therapy (IMRT) on toxicity and to update the largest series on radiation for DSRCT. METHODS AND MATERIALS: The records of 31 patients with DSRCT treated with WAP-RT (22 with 2D-RT and 9 with IMRT) between 1992 and 2011 were retrospectively reviewed...
January 1, 2013: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/22875416/taste-and-smell-function-in-pediatric-blood-and-marrow-transplant-patients
#18
J Cohen, D G Laing, F J Wilkes
BACKGROUND: The intensive conditioning regimens of a pediatric blood and marrow transplant (BMT) can limit voluntary intake leading to a risk of malnutrition. Poor dietary intake is likely multi-factorial with a change in taste and smell function potentially being one contributing factor limiting intake, though this is not well studied. This research aimed to assess the taste and smell function of a cohort of pediatric BMT patients. METHODS: A total of ten pediatric BMT patients (8-15 years) were recruited to this study...
November 2012: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/22536949/blood-graft-composition-after-plerixafor-injection-in-patients-with-nhl
#19
COMPARATIVE STUDY
Ville Varmavuo, Pentti Mäntymaa, Tapio Nousiainen, Piia Valonen, Taru Kuittinen, Esa Jantunen
BACKGROUND: Plerixafor is used to mobilize CD34(+) hematopoietic stem cells from bone marrow to circulation. Limited data are available in regard to graft cellular content collected after plerixafor. OBJECTIVES: The aim of this study was to assess effects of plerixafor added to chemomobilization on graft CD34(+) cell subclasses, lymphocyte subsets, engraftment, and post-transplant course in non-Hodgkin lymphoma (NHL) patients. METHODS: Thirty-four patients with NHL were included...
August 2012: European Journal of Haematology
https://www.readbyqxmd.com/read/22491742/dynamic-international-prognostic-scoring-system-scores-pre-transplant-therapy-and-chronic-graft-versus-host-disease-determine-outcome-after-allogeneic-hematopoietic-stem-cell-transplantation-for-myelofibrosis
#20
Markus Ditschkowski, Ahmet H Elmaagacli, Rudolf Trenschel, Tanja Gromke, Nina K Steckel, Michael Koldehoff, Dietrich W Beelen
BACKGROUND: Myelofibrosis is a myeloproliferative stem cell disorder curable exclusively by allogeneic hematopoietic stem cell transplantation and is associated with substantial mortality and morbidity. The aim of this study was to assess disease-specific and transplant-related risk factors that influence post-transplant outcome in patients with myelofibrosis. DESIGN AND METHODS: We retrospectively assessed 76 consecutive patients with primary (n=47) or secondary (n=29) myelofibrosis who underwent bone marrow (n=6) or peripheral blood stem cell (n=70) transplantation from sibling (n=30) or unrelated (n=46) donors between January 1994 and December 2010...
October 2012: Haematologica
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