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https://www.readbyqxmd.com/read/29759089/thrombocytopenia-in-bacteraemia-and-association-with-bacterial-species
#1
D Johansson, M Rasmussen, M Inghammar
Thrombocytopenia is common in patients with invasive bacterial infections. Bacteria can activate platelets, but it is unclear if this affects platelet count. The aim of this study was to examine whether bacteraemia with Staphylococcus aureus, which readily activate human platelets, was more likely to be complicated by thrombocytopenia than bacteraemia with Escherichia coli or Streptococcus pneumoniae with different abilities to activate platelets.We compared information from 600 adult patients with community-acquired bacteraemia with S...
May 15, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29745277/predictors-of-one-year-all-cause-mortality-and-infection-related-mortality-in-patients-with-staphylococcus-aureus-bacteraemia
#2
Arne Nørgaard Eskesen, Margrethe Astrup Belle, Anita Blomfeldt
OBJECTIVES: Staphylococcus aureus bacteraemia (SAB) is a common infection associated with significant short-term mortality. Little is known about long-term prognosis. The aim of this study was to determine one-year all-cause mortality and infection-related mortality and associated predictors. METHODS: Data from 303 consecutive patients with SAB were prospectively collected from March 2011 to February 2014. All patients were followed one year or until death. RESULTS: One-year all-cause- and infection-related mortality were 36...
May 10, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29736610/occult-bacteremia-etiology-following-the-introduction-of-13-valent-pneumococcal-conjugate-vaccine-a-multicenter-study-in-spain
#3
Susanna Hernández-Bou
Little is known about occult bacteremia (OB) in Spain following the introduction of the 13-valent pneumococcal conjugated vaccine (PCV13). Our aim was to describe the microbiologic characteristics and management of OB among children aged 3-36 months in Spain in the era of PCV13. Data were obtained from a multicenter registry of positive blood cultures collected at 22 Spanish emergency departments (ED). Positive blood cultures performed on patients aged 3-36 months from 2011 to 2015 were retrospectively identified...
May 7, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29735827/molecular-characterisation-for-clonality-and-transmission-dynamics-of-an-outbreak-of-klebsiella-pneumoniae-amongst-neonates-in-a-tertiary-care-centre-in-south-india
#4
Chaitra Shankar, Manish Kumar, Ashtawarthani Baskaran, Miracle Magdelene Paul, Nithya Ponmudi, Sridhar Santhanam, Joy Sarojini Michael, Balaji Veeraraghavan
Purpose: Sepsis is a significant cause of morbidity and mortality amongst neonates. Klebsiella pneumoniae is a common cause of nosocomial outbreaks causing bacteraemia and having potential of acquiring plasmids enhancing antimicrobial resistance. In the present study, we investigate K. pneumoniae outbreak causing bacteraemia amongst neonates over a span of 2 months. Isolates were characterised for antimicrobial resistance, virulence, molecular typing for clonality and plasmid typing for transmission dynamics, and patient outcome was investigated...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29735564/failure-of-daptomycin-to-kill-staphylococcus-aureus-impact-of-bacterial-membrane-fatty-acid-composition
#5
Rym Boudjemaa, Clément Cabriel, Florence Dubois-Brissonnet, Nicolas Bourg, Guillaume Dupuis, Alexandra Gruss, Sandrine Lévêque-Fort, Romain Briandet, Marie-Pierre Fontaine-Aupart, Karine Steenkeste
Daptomycin is a last-resort membrane-targeting lipopeptide approved for the treatment of drug-resistant staphylococcal infections such as bacteraemia and implant-related infections. Although cases of resistance to this antibiotic are rare, increasing clinical, in vitro and animal studies report treatment failure, notably against Staphylococcus aureus The aim of this study was to identify the features of daptomycin and its target bacteria that lead to daptomycin treatment failure. We show that daptomycin bactericidal activity against S...
May 7, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29725958/prevalence-and-molecular-diversity-of-invasive-streptococcus-dysgalactiae-and-streptococcus-pyogenes-in-a-german-tertiary-care-medical-centre
#6
S Rößler, R Berner, E Jacobs, N Toepfner
Prevalence of invasive ß-haemolytic streptococci (BHS) at a tertiary care hospital and molecular diversity of S. pyogenes and S. dysgalactiae was studied. Between 2012 and 2016, all blood culture sets (n = 55,839), CSF (n = 8413) and soft tissue (n = 20,926) samples were analysed for BHS positivity using HYBASE software. Molecular profiles of 99 S. pyogenes and S. dysgalactiae were identified by sequencing of M protein genes (emm types) and multiplex PCR typing of 20 other virulence determinants. Streptococci contributed to 6...
May 3, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29721836/roultella-ornithinolytica-infection-in-infancy-a-case-of-febrile-urinary-tract-infection
#7
Laura De Petris, Ermanno Ruffini
Raoultella ornithinolytica is a Gram-negative, non-motile, encapsulated, aerobic bacillus belonging to the Enterobacteriaceae family. R. ornithinolytica is a not very common, but emergent causal agent of human infection, and its expression of beta-lactamase provides resistance to commonly used antibiotics. The pathogenetic potential of R. ornithinolytica isolates in human disease has become increasingly important. Several cases of hospital-acquired infection, mostly associated with invasive procedures, or in patients with co-morbidity caused by R...
May 2, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29705558/decision-support-models-for-empiric-antibiotic-selection-in-gram-negative-bloodstream-infections
#8
D R MacFadden, B Coburn, N Shah, A Robicsek, R Savage, M Elligsen, N Daneman
OBJECTIVES: Early empiric antibiotic therapy in patients can improve clinical outcomes in Gram-negative bacteraemia. However, the widespread prevalence of antibiotic-resistant pathogens compromises our ability to provide adequate therapy while minimizing use of broad antibiotics. We sought to determine whether readily available electronic medical record data could be used to develop predictive models for decision support in Gram-negative bacteraemia. METHODS: We performed a multi-centre cohort study, in Canada and the USA, of hospitalized patients with Gram-negative bloodstream infection from April 2010 to March 2015...
April 25, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29704110/systematic-review-and-meta-analysis-investigating-the-efficacy-and-safety-of-probiotics-in-people-with-cancer
#9
REVIEW
Hadeel Hassan, M Rompola, A W Glaser, S E Kinsey, R S Phillips
BACKGROUND/OBJECTIVES: Probiotics are living microorganisms that confer a health benefit on the host when administered. This systematic review and meta-analysis investigates the efficacy and safety of probiotics in adult and paediatric patients diagnosed with cancer. METHODS: A systematic review and meta-analysis was undertaken (PROSPERO registration: CRD42016050252). Randomised controlled trials (RCT), identified through screening multiple databases were included for analysis of efficacy...
April 27, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29693470/chryseobacterium-bacteraemia-a-single-centre-case-series
#10
Justo Sandino Pérez, Ana Maria Mancilla, Edgar Pérez Barragán, Mario Fernández-Ruiz
No abstract text is available yet for this article.
April 25, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29691073/microbiological-diagnosis-of-bacteraemia-and-fungaemia-blood-cultures-and-molecular-methods
#11
María Remedio Guna Serrano, Nieves Larrosa Escartín, Mercedes Marín Arriaza, Juan Carlos Rodríguez Díaz
OBJETIVE: In this review we try to update the new procedures applicable in the microbiological diagnosis of bacteriemia and fungemias. METHOD: Review of scientific literature. RESULTS AND CONCLUSIONS: After defining the process and indicating its fundamental principles, the main biomarkers used in clinical practice are reviewed. Subsequently, the particularities of the pre-analytical phase (collection and transport of samples) are highlighted and the steps to follow for the microbiological identification by classical methods are detailed, based on the culture of the blood samples...
April 21, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29690994/-spontaneous-bacterial-peritonitis-and-bacteraemia-caused-by-meningococci-serogroup-w-clonal-complex-11
#12
Martin Søholm Iversen, Steen Hoffmann, Katrine Lind, Arnold Dungu, Thor Bech Johannesen, Barbara J Holzknecht
In recent years, the incidence of invasive meningococcal disease (IMD) caused by serogroup W (SG-W) has been rising, in particular SG-W within clonal complex 11 (cc11), which has caused epidemics and is believed to cause severe and atypical IMD. This is a case report of spon-taneous bacterial peritonitis and bacteraemia caused by meningococci SG-W cc11 in a 60-year-old female with systemic lupus erythematosus in prolonged remission as her only risk factor. Antibiotic therapy was initiated at admission, and peritoneal lavage was performed...
April 16, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29690991/-treatment-of-vancomycin-resistant-enterococcal-infections
#13
Lars Christian Lund, Barbara Juliane Holzknecht, Ulrik Stenz Justesen
Vancomycin-resistant enterococci (VRE) are a growing healthcare concern, and since 2012 the incidence has increased eightfold in Denmark. Treatment options for infections with ampicillin-resistant VRE are sparse, and there are no Danish guidelines concerning this topic. For treatment of uncomplicated VRE urinary tract infections, ciprofloxacin or nitrofurantoin can be used. The mainstay of treatment of bacteraemia and other severe infections caused by VRE is linezolid or high-dose daptomycin. Combination treatment is recommended for complicated infections and/or prolonged therapy...
April 16, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29690983/-shewanella-algae-bacteriaemia-after-a-vacation-in-thailand
#14
Anja Sofie Petersen, Frederik Federspiel, Arnold Dungu, Christian Søborg
This is a case report of a 56-year-old man, who presented with a very rare cause of erysipelas and bacteraemia caused by the Gram-negative bacillus Shewanella algae. To our knowledge, this is the first reported case of imported Shewanella-infection in Denmark. The patient, who had a history of liver cirrhosis, returned home from a one-month vacation in Thailand. All four blood cultures were positive for S. algae. The patient was treated successfully with IV meropenem and oral ciprofloxacin. S. algae can cause severe local and systemic infection and is not sensitive to standard treatment with penicillin...
April 9, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29688339/4-5-years-within-patient-evolution-of-a-colistin-resistant-kpc-producing-klebsiella-pneumoniae-st258
#15
Agnès B Jousset, Rémy A Bonnin, Isabelle Rosinski-Chupin, Delphine Girlich, Gaëlle Cuzon, Nicolas Cabanel, Hélène Frech, Eric Farfour, Laurent Dortet, Philippe Glaser, Thierry Naas
Background: KPC-producing Klebsiella pneumoniae (KPC-Kp) have emerged globally over the last decade as a major nosocomial pathogen that threatens patient's care. These highly resistant bacteria are mostly associated with a single Kp clonal group (CG) CG258, but the reasons for its host and hospital adaptation remain largely unknown. Methods: We analyzed the in vivo evolution of a colistin-resistant KPC-Kp-CG258 strain that contaminated a patient following an endoscopy, and was responsible for a fatal bacteraemia 4...
April 21, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29687943/plasma-cell-free-dna-and-qsofa-score-predict-7-day-mortality-in-481-emergency-department-bacteraemia-patients
#16
Juha Rannikko, Tapio Seiskari, Reetta Huttunen, Iina Tarkiainen, Juulia Jylhävä, Mikko Hurme, Jaana Syrjänen, Janne Aittoniemi
BACKGROUND: A few studies have shown that both quick Sequential Organ Failure Assessment (qSOFA) score and cell-free DNA (cfDNA) have potential use as a prognostic marker in patients with infection. We studied these two markers alone and in combination to identify those emergency department (ED) patients with the highest risk of death. METHODS: Plasma cfDNA level was studied on days 0 to 4 after admittance to the ED from 481 culture-positive bloodstream infection cases...
April 24, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29684360/interleukin-6-drives-neutrophil-mediated-pulmonary-inflammation-associated-with-bacteraemia-in-murine-models-of-colitis
#17
Sean W Mateer, Andrea Mathe, Jessica Bruce, Gang Liu, Steven Maltby, Michael Fricker, Bridie J Goggins, Hock L Tay, Ellen Marks, Grace Burns, Richard Y Kim, Kyra Minahan, Marjorie M Walker, Robert C Callister, Paul S Foster, Jay C Horvat, Philip M Hansbro, Simon Keely
Inflammatory bowel disease (IBD) is associated with a number of immune-mediated extra-intestinal manifestations. Over half of all IBD patients have some form of respiratory pathology, most commonly neutrophil-mediated diseases such as bronchiectasis and chronic bronchitis. Using murine models of colitis, we aimed to identify the immune mechanisms driving pulmonary manifestations of IBD. We found increased neutrophil numbers in lung tissue associated with the pulmonary vasculature in both trinitrobenzenesulfonic acid- and dextran sulfate sodium-induced models of colitis...
April 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29684028/does-chlorhexidine-reduce-bacteremia-following-tooth-extraction-a-systematic-review-and-meta-analysis
#18
Iciar Arteagoitia, Carlos Rodriguez Andrés, Eva Ramos
BACKGROUND AND AIMS: Scientific evidence is not clear regarding the use of antimicrobial mouth rinse before dental extraction to reduce bacteremia. We tested the null hypothesis that there would be no difference in the incidence of bacteremia following dental extractions in patients treated with or without chlorhexidine. MATERIAL AND METHODS: We conducted a meta-analysis following the recommendations proposed by PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses...
2018: PloS One
https://www.readbyqxmd.com/read/29680262/clinical-implications-of-intravenous-drug-incompatibilities-in-critically-ill-patients
#19
REVIEW
Malik Benlabed, Maxime Perez, Romain Gaudy, Stéphanie Genay, Damien Lannoy, Christine Barthélémy, Pascal Odou, Gilles Lebuffe, Bertrand Décaudin
OBJECTIVE: The aim of this review is to analyse the clinical consequences of intravenous drug incompatibilities in critically ill patients, especially the incidence of organ dysfunctions and mortality. METHODS: A review of literature was conducted according to the PRISMA statement in June 2017, using Medline, ISI Web of Science and Clinicaltrials.gov. DATA EXTRACTION: Eligible studies were case reports and randomised controlled trials (RCTs) that assessed the effects of drug incompatibilities in critically ill patients on morbidity or mortality as primary or secondary outcomes, or adverse events...
April 19, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29679416/sequential-bacterial-sampling-of-the-midline-incision-in-horses-undergoing-exploratory-laparotomy
#20
C M Isgren, S E Salem, N B Townsend, D Timofte, T W Maddox, D C Archer
BACKGROUND: There is limited information about bacterial isolates that are present on the equine midline incision during and following exploratory laparotomy. OBJECTIVES: To investigate the bacterial species cultured from the ventral midline pre-, intra- and post laparotomy, whether particular bacterial isolates are associated with the development of surgical site infections (SSIs) and to report the antimicrobial resistance phenotypes of these isolates. STUDY DESIGN: Prospective cohort study...
April 20, 2018: Equine Veterinary Journal
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