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https://www.readbyqxmd.com/read/28750420/a-10-year-observational-study-of-streptococcus-dysgalactiae-bacteraemia-in-adults-frequent-occurrence-among-female-intravenous-drug-users
#1
Corinne Ruppen, Magnus Rasmussen, Carlo Casanova, Parham Sendi
Beta-haemolytic streptococci of groups C and G have become increasingly recognized as causes of invasive human infections. We reviewed clinical and molecular characteristics of Streptococcus dysgalactiae isolates that caused bacteraemia in adults from 2006 to 2015. Among 67 episodes, skin and soft-tissue infections (43%) and emm types stG62647.0 (26%) were the most frequent clinical manifestation and emm type, respectively. Nineteen (28%) episodes occurred in intravenous drug users (75% women). Our observational study shows similarities to but also differences from other reports...
July 27, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28747416/discitis-and-clostridium-perfringens-bacteraemia
#2
Chen Han Yong, Miranda Lam
The authors present a case involving an 80-year-old man with infectious T10/T11 discitis on the background of a recent Clostridium perfringens bacteraemia. This case report describes a case of probable C. perfringens discitis as further investigations failed to identify any causative agents. He was treated with intravenous piperacillin/tazobactam to good effect, achieving favourable clinical outcome. Diagnosis of discitis/osteomyelitis can often be delayed and mismanaged due to its non-specific presentations...
July 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28746204/direct-acting-antiviral-agent-efficacy-and-safety-in-renal-transplant-recipients-with-chronic-hepatitis-c-virus-infection-a-prisma-compliant-study
#3
Keliang Chen, Pei Lu, Rijin Song, Jiexiu Zhang, Rongzhen Tao, Zijie Wang, Wei Zhang, Min Gu
BACKGROUND: The efficacy and safety of direct-acting antivirals (DAAs) for treating hepatitis C virus (HCV)-infected renal transplant recipients (RTRs) has not been determined. METHODS: We searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials and assessed the quality of eligible studies using the Joanna Briggs Institute scale. DAA efficacy and safety were assessed using standard mean difference (SMD) with 95% confidence intervals (95%CIs)...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28743653/a-review-of-arterio-venous-fistulae-creation-in-octogenarians
#4
Jennifer Clarissa Diandra, Zhiwen Joseph Lo, Wei-Wen Ang, Jue Fei Feng, Sriram Narayanan, Glenn Wei Leong Tan, Sadhana Chandrasekar
BACKGROUND: To analyse the outcomes of arterio-venous fistulae (AVF) creation in Octogenarians. METHODS: Retrospective study of 47 AVFs created in patients aged 80 years and above from 2008 to 2014. Patient and AVF characteristics and outcomes were evaluated. Predictors of patency were analysed with multivariate analysis and Kaplan-Meier patency and survival analysis was performed. RESULTS: 47 of 1,259 AVFs created were for Octogenarians (4%)...
July 22, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28743533/should-non-bacteremic-patients-with-a-colonized-catheter-receive-antimicrobial-therapy
#5
V De Egea, M Guembe, A Rodríguez-Borlado, M J Pérez-Granda, C Sánchez-Carrillo, E Bouza
OBJECTIVES: The impact of antimicrobial therapy on the outcome of patients with colonized catheters and no bacteraemia has not been assessed. We assessed whether targeted antibiotic therapy was related for having poor outcome (PO) in patients with positive cultures of blood drawn through a non-tunneled central venous catheter (CVC) and without concomitant bacteraemia. METHODS: We performed a retrospective study in which we selected adult patients with positive blood cultures drawn through a CVC and negative peripheral vein blood cultures...
July 22, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28737340/-healthcare-associated-bacteraemia-in-intensive-care-units-of-ibn-rochd-university-hospital-casablanca
#6
Assiya El Kettani, Khalid Zerouali, Idrissa Diawara, Mohamed Ouhadous, Nadia Harrar, Houria Belabbes, Naima Elmdaghri
Objective: This study was designed to determine the incidence of healthcare-associated bacteraemia in intensive care units (ICU) of Ibn Rochd University Hospital, Casablanca, Morocco, the frequency of the bacterial strains isolated and their antibiotic resistance patterns. Methods: A prospective longitudinal study was conducted between May and July 2015 on patients admitted to the Ibn Rochd University Hospital ICU. The Comité technique des infections nosocomiales et des infections liées aux soins (CITNILS) definition of bacteraemia was used...
April 27, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28735313/early-kpc-producing-klebsiella-pneumoniae-bacteremia-among-intensive-care-unit-patients-non-colonized-upon-admission
#7
Matthaios Papadimitriou-Olivgeris, Fotini Fligou, Iris Spiliopoulou, Christina Bartzavali, Vasiliki Dodou, Sophia Vamvakopoulou, Kyriaki Koutsileou, Anastasia Zotou, Evangelos D Anastassiou, Myrto Christofidou, Markos Marangos
Among 140 patients colonized by KPC-producing Klebsiella pneumoniae (KPC-Kp) between fourth and seventh day of Intensive Care Unit stay, 24 developed bacteraemia immediately after colonization. Colistin-resistance of the colonizing isolate was the factor significantly associated with early KPC-Kp bacteraemia (P < 0.001; OR 6.6, 95% CI 2.4-18.4), a worrisome finding since infections by colistin-resistant isolates is associated with increased mortality due to limited remaining therapeutic options.
July 6, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/28731899/current-perspectives-on-invasive-nontyphoidal-salmonella-disease
#8
Andrea H Haselbeck, Ursula Panzner, Justin Im, Stephen Baker, Christian G Meyer, Florian Marks
PURPOSE OF REVIEW: We searched PubMed for scientific literature published in the past 2 years for relevant information regarding the burden of invasive nontyphoidal Salmonella disease and host factors associated with nontyphoidal Salmonella infection and discuss current knowledge on vaccine development. The following search terms were used: Salmonella, non typhoidal/nontyphoidal, NTS, disease, bloodstream infection, invasive, sepsis/septicaemia/septicemia, bacteraemia/bacteremia, gastroenteritis, incidence, prevalence, morbidity, mortality, case fatality, host/risk factor, vaccination, and prevention/control...
July 20, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28710229/pirate-project-point-of-care-informatics-based-randomised-controlled-trial-for-decreasing-overuse-of-antibiotic-therapy-in-gram-negative-bacteraemia
#9
Angela Huttner, Werner C Albrich, Pierre-Yves Bochud, Angèle Gayet-Ageron, Anne Rossel, Elodie von Dach, Stephan Harbarth, Laurent Kaiser
INTRODUCTION: Antibiotic overuse drives antibiotic resistance. The optimal duration of antibiotic therapy for Gram-negative bacteraemia (GNB), a common community and hospital-associated infection, remains unknown and unstudied via randomised controlled trials (RCTs). METHODS AND ANALYSIS: This investigator-initiated, multicentre, non-inferiority, informatics-based point-of-care RCT will randomly assign adult hospitalised patients receiving microbiologically efficacious antibiotic(s) for GNB to (1) 14 days of antibiotic therapy, (2) 7 days of therapy or (3) an individualised duration determined by clinical response and 75% reduction in peak C reactive protein (CRP) values...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28705846/a-novel-case-of-raoultella-planticola-osteomyelitis-and-epidural-abscess
#10
Rogin Subedi, Ryan Dean, William Li, Amit Dhamoon
A spinal epidural abscess is the collection of pus in the epidural space, and is a potentially life-threatening condition that requires early detection and prompt management. Almost two-thirds of cases are caused by Staphylococcus aureus, followed by Gram-negative bacilli which account for approximately 16% of cases. Raoultella planticola is an emerging pathogen, and is an extremely rare cause of invasive infection in humans. It has been reported to cause urinary tract infections, pneumonia, bacteraemia, cholangitis, cholecystitis, conjunctivitis and soft tissue infections...
July 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28705672/role-of-vancomycin-in-the-treatment-of-bacteraemia-and-meningitis-caused-by-elizabethkingia-meningoseptica
#11
REVIEW
Shio-Shin Jean, Tai-Chin Hsieh, Yong-Zhong Ning, Po-Ren Hsueh
Elizabethkingia meningoseptica, a Gram-negative pathogen once deemed clinically insignificant, tends to cause infections amongst the low-birth-weight infants or immunocompromised patients. Previously, vancomycin was reported to cure a few patients with bacteraemia caused by E. meningoseptica. Nevertheless, some laboratory investigations also showed considerable discordance between in vitro vancomycin susceptibility results obtained by the disc diffusion and broth microdilution method against clinical E. meningoseptica isolates as determined by the criteria for staphylococci recommended by the Clinical and Laboratory Standards Institute (formerly, National Committee for Clinical Laboratory Standards)...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28705667/clinical-characteristics-of-bacteraemia-caused-by-burkholderia-cepacia-complex-species-and-antimicrobial-susceptibility-of-the-isolates-in-a-medical-centre-in-taiwan
#12
Ying-Chun Chien, Chun-Hsing Liao, Wang-Huei Sheng, Jung-Yien Chien, Yu-Tsung Huang, Chong-Jen Yu, Po-Ren Hsueh
This study investigated the clinical characteristics and outcomes of bacteraemia due to Burkholderia cepacia complex (BCC) species among 54 patients without cystic fibrosis from January 2013 to February 2015. BCC isolates were identified to the species level by the Bruker Biotyper MALDI-TOF MS system and by sequencing analysis of the 16S rRNA and recA genes. Antimicrobial susceptibilities of the isolates were determined by the agar dilution method. Sequencing of the recA gene in the 54 blood isolates revealed 37 (68...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28693606/combined-use-of-serum-1-3-%C3%AE-d-glucan-and-procalcitonin-for-the-early-differential-diagnosis-between-candidaemia-and-bacteraemia-in-intensive-care-units
#13
Daniele Roberto Giacobbe, Malgorzata Mikulska, Mario Tumbarello, Elisa Furfaro, Marzia Spadaro, Angela Raffaella Losito, Alessio Mesini, Gennaro De Pascale, Anna Marchese, Marco Bruzzone, Paolo Pelosi, Michele Mussap, Alexandre Molin, Massimo Antonelli, Brunella Posteraro, Maurizio Sanguinetti, Claudio Viscoli, Valerio Del Bono
BACKGROUND: This study aimed to assess the combined performance of serum (1,3)-β-D-glucan (BDG) and procalcitonin (PCT) for the differential diagnosis between candidaemia and bacteraemia in three intensive care units (ICUs) in two large teaching hospitals in Italy. METHODS: From June 2014 to December 2015, all adult patients admitted to the ICU who had a culture-proven candidaemia or bacteraemia, as well as BDG and PCT measured closely to the time of the index culture, were included in the study...
July 10, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28689228/impact-of-a-rapid-molecular-test-for-positive-blood-cultures-from-neonatal-intensive-care-patients-on-clinical-management-a-retrospective-audit
#14
L L Koh, S O'Rourke, M Brennan, L Clooney, M Cafferkey, N McCallion, R J Drew
BACKGROUND: Both Staphylococcus aureus and coagulase negative Staphylococci are common causes of late-onset neonatal sepsis in the neonatal intensive care unit (NICU), usually relating to intravascular access device infections. AIMS: This project aimed to review the impact on antimicrobial treatment and clinical outcome in the NICU setting, of the introduction of the Xpert MRSA/SA BC test (Cepheid, USA) for the identification of staphylococci in blood cultures. METHODS: A retrospective audit was carried out of the pre- and post-intervention periods; the intervention was the introduction of the Xpert MRSA/SA BC test...
July 8, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28687185/identifying-hospital-onset-escherichia-coli-bacteraemia-cases-from-english-mandatory-surveillance-the-case-for-applying-a-two-day-post-admission-rule
#15
John Davies, Alan P Johnson, Russell Hope
BACKGROUND: A national voluntary surveillance programme has shown year-on-year increases in the number of bacteraemias caused by Escherichia coli. Mandatory surveillance of E. coli bacteraemia was introduced in 2011 with the aim of improving the quantity and quality of data collected. In contrast to the other national mandatory surveillance programmes, cases are not currently categorised based upon time of onset in relation to hospital admission. AIM: To assess the case for applying time of onset categorisation to cases of E...
July 4, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28681809/an-outbreak-of-burkholderia-cepacia-complex-in-the-paediatric-unit-of-a-tertiary-care-hospital
#16
Swapna Mali, Lona Dash, Vikas Gautam, Jayanthi Shastri, Sunil Kumar
INTRODUCTION: Burkholderia cepacia complex (Bcc) has emerged as a serious nosocomial pathogen worldwide especially in patients with indwelling catheters and cystic fibrosis. Bcc is a common contaminant of pharmaceutical products. We describe an outbreak of Bcc bacteraemia amongst children admitted in Paediatric Intensive Care Unit (PICU) and paediatric ward at a tertiary care hospital, Mumbai, in Western India. MATERIALS AND METHODS: Blood culture samples from paediatric patients yielded growth of non-fermenting, oxidase positive, motile, Gram negative bacilli (NFGNB) (76/909) over a period of 8 months...
April 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28670975/carbapenem-resistant-klebsiella-pneumoniae-isolated-from-bloodstream-infection-indian-experience
#17
Balaji Veeraraghavan, Chaitra Shankar, Susmitha Karunasree, Shantha Kumari, Raji Ravi, Ravikar Ralph
Increased incidence of multidrug resistant (MDR) Gram negative infection has resulted in high rates of morbidity and mortality. Klebsiella pneumoniae is one of the commonest MDR pathogens causing bacteraemia with limited therapeutic options such as colistin and tigecycline. Present study focused on molecular characterisation of MDR K. pneumoniae from bloodstream infection and their clinical outcome. A total of 115 K. pneumoniae from January 2015 to September 2016 were included in the study which comprised of phenotypically identified ESBL and carbapenem resistant (CR) isolates...
July 2, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28669198/pathological-and-microbiological-investigations-into-cases-of-bacterial-chondronecrosis-and-osteomyelitis-in-broiler-poultry
#18
Dinidu S Wijesurendra, Anthony Neal Chamings, Rhys Nathan Bushell, Denise O' Rourke, Mark Stevenson, Marc Serge Marenda, Amir H Noormohammadi, Andrew Stent
Bacterial chondronecrosis and osteomyelitis (BCO) is increasingly recognised as a major cause of lameness in commercial broilers chickens worldwide, but the pathogenesis of the condition is incompletely understood. This was a longitudinal study of 20 commercial broiler farms in Victoria, Australia to investigate the etiology and pathology of BCO. Thorough postmortem examination was performed on culled and dead birds (n=325) from 20 different flocks at either 1 week, 4 weeks or 5 weeks of age and samples were analysed by conventional bacteriology, molecular identification of infectious organisms detected, serology and histopathology...
July 3, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28668676/comparison-of-the-therapeutic-efficacy-of-fluoroquinolone-and-non-fluoroquinolone-treatment-in-patients-with-elizabethkingia-meningoseptica-bacteraemia
#19
Ying-Chi Huang, Yi-Tsung Lin, Fu-Der Wang
Elizabethkingia meningoseptica is a non-fermentative Gram-negative bacillus that has emerged as an important pathogen in nosocomial infections and is usually associated with high mortality. E. meningoseptica is inherently resistant to many broad-spectrum antibiotics, and appropriate antibiotic selection is crucial for survival. Data about the therapeutic efficacy of fluoroquinolone in E. meningoseptica bacteraemia are limited. We retrospectively enrolled patients with E. meningoseptica bacteraemia who were treated with a single antimicrobial agent with in vitro activity against E...
June 28, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28667056/endogenous-endophthalmitis-and-osteomyelitis-associated-with-interleukin-17-inhibitor-treatment-for-psoriasis-in-a-patient-with-diabetes
#20
Christine E Martinez, John B Allen, Frederick H Davidorf, Colleen M Cebulla
A 64-year-old man with type 2 diabetes mellitus and plaque psoriasis presented to the emergency room with 3 days of progressive right eye pain and decreased vision. After extensive workup and multidisciplinary team effort, the patient was diagnosed with and treated for unilateral endogenous methicillin-sensitive Staphylococcus aureus endophthalmitis, bacteraemia and osteomyelitis of the foot. The patient had been started on the interleukin 17 (IL-17) inhibitor secukinumab for his treatment-resistant plaque psoriasis 4 weeks prior to presentation...
June 29, 2017: BMJ Case Reports
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