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https://www.readbyqxmd.com/read/29164361/bacteraemia-in-emergency-departments-effective-antibiotic-reassessment-is-associated-with-a-better-outcome
#1
Charlotte Aillet, Didier Jammes, Agnès Fribourg, Sophie Léotard, Olivier Pellat, Patricia Etienne, Dominique Néri, Djamel Lameche, Olivier Pantaloni, Serge Tournoud, Pierre-Marie Roger
Patients with bacteraemia constitute an useful population for an audit of antibiotic treatments. Empirical antibiotic therapy (EAT) and its reassessment must take into account clinical data and microbiological results. Our aim was to determine the impact of these sequential steps of the therapy on survival. This was a retrospective multicentre study which included patients admitted to emergency departments (ED) for whom blood cultures were positive over a 4-month period. Microbial results were compiled from the database of the laboratories...
November 21, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29162493/outbreak-of-gentamicin-resistant-meticillin-susceptible-staphlococcus-aureus-on-a-neonatal-unit
#2
Sahar Eldirdiri, Jennifer Lee, Ann Jack, Alison Wright, Alison Findlay, Gabby Phillips
BACKGROUND: This report describes an outbreak of gentamicin-resistant meticillin-resistant Staphylococcus aureus (GR MSSA) which occurred on a 21-bed neonatal unit (NNU) in Ninewells Hospital, Dundee, Scotland. METHODS: An outbreak investigation was triggered by two new GR MSSA isolates from babies admitted directly to the unit who had acquired this organism during their stay. Data on MSSA cases and antibiograms of patient isolates were flagged as an alert and microbiology records trawled to detect previous cases...
November 18, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29162280/catheter-related-bacteraemia-caused-by-raoultella-ornithinolytica
#3
A González-Castro, J C Rodríguez-Borregán, S Campos, J L Pérez Canga
Infections in humans by Raoultella spp. are rare and the effect that Raoultella spp. might have as a human pathogen is currently unknown. A clinical case is presented of catheter-related bacteraemia caused by Raoultella ornithinolytica, treated successfully with applied antibiotic therapy (intravenous cefepime and sealed the catheter with amikacin).
November 18, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29161941/are-we-missing-the-staphylococcus-aureus-bacteraemia-forest-for-the-mrsa-trees
#4
Kevin B Laupland
In this edition of the journal, Jokinen et al. report on a population based study of Staphylococcus aureus bacteraemia (SAB) in Finland. They observe increasing incidence of cases over time that are associated with an increase in blood culture sampling. As compared to methicillin-sensitive SAB that increases during the study period, the incidence of methicillin-resistant SAB increases and then decreases. The proportion of cases with penicillin-sensitive SAB markedly increases in the study representing 43% of isolates in the most recent year of surveillance...
November 21, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29150336/urinary-tract-infections-in-neonates-with-unexplained-pathological-indirect-hyperbilirubinemia-prevalence-and-significance
#5
Elif Bahat Ozdogan, Mehmet Mutlu, Secil Arslansoyu Camlar, Gülcin Bayramoglu, Sebnem Kader, Yakup Aslan
BACKGROUND: It is controversial to test for urinary tract infection (UTI) in patients with unexplained indirect hyperbilirubinemia in the first 2 weeks of life. We aimed to study the prevalence and significance of UTIs in such neonates who were requiring phototherapy. METHODS: Subjects were 2- to 14-day-old neonates with indirect bilirubin levels above phototherapy limit with no other abnormality in their bilirubinaemia-related etiologic workup. UTI was diagnosed by 2 consecutive positive cultures obtained by catheterisation, documenting growth of >10,000 colonies of the same microorganism with consistent antibiograms...
October 28, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29147662/effectiveness-of-a-lytic-phage-srg1-against-vancomycin-resistant-enterococcus-faecalis-in-compost-and-soil
#6
Sidra Rahmat Ullah, Saadia Andleeb, Taskeen Raza, Muhsin Jamal, Khalid Mehmood
Nosocomial infections caused by vancomycin-resistant Enterococcus have become a major problem. Bacteriophage therapy is proposed as a potential alternative therapy. Bacteriophages are viruses that infect bacteria and are ubiquitous in nature. Lytic bacteriophage was isolated from sewage water that infects VREF, the causative agent of endocarditis, bacteraemia, and urinary tract infections (UTIs). The phage produced clear plaques with unique clear morphology and well-defined boundaries. TEM results of phage revealed it to be 108 ± 0...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29146039/clinical-features-and-outcomes-of-bacteraemia-due-to-oxa-48-like-carbapenemase-producing-klebsiella-pneumoniae-in-a-tertiary-hospital
#7
Ana Madueño, Jonathan González-García, María Del Mar Alonso Socas, María Antonia Miguel Gómez, María Lecuona
INTRODUCTION: Limited therapeutic options and high mortality make the management of OXA-48-like carbapenemase-producing Klebsiella pneumoniae (KPOXA-48) bacteraemia complicated. The aim of the study was to describe the clinical characteristics of KPOXA-48 bacteraemia between October 2013 and December 2016. MATERIAL AND METHODS: The variables to analyse were retrospectively collected from medical records. Carbapenemase production was confirmed by phenotypic and molecular methods...
November 13, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29145465/hospital-associated-methicillin-resistant-staphylococcus-aureus-a-cross-sectional-analysis-of-risk-factors-in-south-african-tertiary-public-hospitals
#8
Liliwe L Shuping, Lazarus Kuonza, Alfred Musekiwa, Samantha Iyaloo, Olga Perovic
INTRODUCTION: Hospital-associated methicillin-resistant S. aureus (HA-MRSA) remains a significant cause of morbidity and mortality worldwide. We conducted a study to determine risk factors for HA-MRSA in order to inform control strategies in South Africa. METHODS: We used surveillance data collected from five tertiary hospitals in Gauteng and Western Cape provinces during 2014 for analysis. A case of HA-MRSA was defined as isolation of MRSA from a blood culture 48 hours after admission and/or if the patient was hospitalised in the six months prior to the current culture...
2017: PloS One
https://www.readbyqxmd.com/read/29129636/inflammation-mediated-muscle-metabolic-dysregulation-local-and-remote-to-the-site-of-major-abdominal-surgery
#9
Krishna K Varadhan, Dumitru Constantin-Teodosiu, Despina Constantin, Paul L Greenhaff, Dileep N Lobo
BACKGROUND & AIMS: Postoperative hyperglycaemia is common in patients having major surgery and is associated with adverse outcomes. This study aimed to determine whether bacteraemia contributed to postoperative systemic inflammation, and whether increases in the expression of muscle mRNAs and proteins reflecting increased muscle inflammation, atrophy and impaired carbohydrate oxidation were evident at the time of surgery, and both local and distant to the site of trauma, and could be associated with impaired glucoregulation...
November 2, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29127125/vancomycin-resistant-enterococcus-faecium-bacteraemia-as-a-complication-of-kayexalate-sodium-polystyrene-sulfonate-sps-in-sorbitol-induced-ischaemic-colitis
#10
Roberto Christian Cerrud-Rodriguez, Diego Alcaraz-Alvarez, Brian Bobby Chiong, Abdurhman Ahmed
We present the case report of an 80-year-old woman with chronic kidney disease stage G5 admitted to the hospital with fluid overload and hyperkalaemia. Sodium polystyrene sulfonate (SPS, Kayexalate) in sorbitol suspension was given orally to treat her hyperkalaemia, which precipitated an episode of SPS in sorbitol-induced ischaemic colitis with the subsequent complication of vancomycin-resistant Enterococcus (VRE) bacteraemia. SPS (Kayexalate) in sorbitol suspension has been implicated in the development of intestinal necrosis...
November 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29125082/-splenic-abscess
#11
A J van Tienhoven, W M Lambers, T P Tan, B A van Wagensveld, P Peerboom, J Veenstra
Splenic abscess is a rare and potentially lethal clinical condition. The most common symptoms of a splenic abscess - abdominal pain, nausea and fever - are non-specific. As a result, a splenic abscess is often not considered in the initial work-up. This might lead to a delay in diagnosis and treatment. In this case series we successively describe a 41-year-old female with a splenic abscess after Streptococcus milleri bacteraemia, a 78-year-old male with a splenic abscess caused by a colon carcinoma and a 52-year-old male with a splenic abscess resulting from a colosplenic fistula after bariatric surgery...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29122896/persistent-bacteraemia-caused-by-staphylococcus-aureus-in-the-gall-bladder
#12
Alexander Tin Han Yu, Tony Cun, Esther Benamu, Cybele Renault
Staphylococcus aureusbacteraemia (SAB) remains a complex disease with a high associated morbidity and mortality, especially when it is able to establish an occult nidus safe from antimicrobial eradication. Without rapid identification and intervention, the nidus can cause persistent relapse of disease, morbidity and mortality. Having a high clinical suspicion for the foci of occult S. aureus is important, and awareness of potential sites of infection is critical and can be life-saving.We present a unique case of a 65-year-old man with end-stage renal disease receiving haemodialysis who developed septic shock from SAB...
November 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29122787/effect-of-daily-antiseptic-body-wash-with-octenidine-on-nosocomial-primary-bacteraemia-and-nosocomial-multidrug-resistant-organisms-in-intensive-care-units-design-of-a-multicentre-cluster-randomised-double-blind-cross-over-study
#13
Anne Meißner, Dirk Hasenclever, Oana Brosteanu, Iris Freya Chaberny
INTRODUCTION: Nosocomial infections are serious complications that increase morbidity, mortality and costs and could potentially be avoidable. Antiseptic body wash is an approach to reduce dermal micro-organisms as potential pathogens on the skin. Large-scale trials with chlorhexidine as the antiseptic agent suggest a reduction of nosocomial infection rates. Octenidine is a promising alternative agent which could be more effective against Gram-negative organisms. We hypothesise that daily antiseptic body wash with octenidine reduces the risk of intensive care unit (ICU)-acquired primary bacteraemia and ICU-acquired multidrug-resistant organisms (MDRO) in a standard care setting...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29114396/molecular-evidence-of-listeria-monocytogenes-infection-relapse-in-a-severe-case-of-endocarditis
#14
Giulia Ciceri, Maria Gori, Silvia Bianchi, Giovanni Corrado, Paolo Panisi, Angela Papa, Elisabetta Tanzi, Mirella Pontello
Introduction. Endocarditis is a rare complication of bacteraemia due to Listeria monocytogenes and is characterized by a high fatality rate (37-50 %). Recurrent infection by Listeria monocytogenes occurs even more rarely. Case presentation. We report a case of recurrent Listeria monocytogenes infection that resulted in severe endocarditis in a 66-year-old patient with an aortic valve prosthesis. Relapse was confirmed by pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST). Conclusion...
September 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29114394/staphylococcus-caprae-bacteraemia-and-native-bone-infection-complicated-by-therapeutic-failure-and-elevated-mic-a-case-report
#15
Carolyn A Hilliard, Jad El Masri, Michihiko Goto
Introduction.Staphylococcus caprae is a coagulase-negative staphylococcus that has been reported in several cases as a human pathogen. However, it has rarely been reported as pathogen in native bone. Furthermore, the reported MIC levels noted in the literature for vancomycin were <2 µg ml(-)(1)making vancomycin a first line choice for infected patients. Case presentation. We report a case of Staphylococcus caprae causing osteomyelitis of the lumbar spine and bacteraemia and resulting in sepsis and ultimately the demise of a patient despite appropriate prolonged antibiotic therapy...
September 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29114392/a-common-pathogen-in-an-uncommon-site-coronary-artery-stent-meticillin-resistant-staphylococcus-aureus-infection
#16
Krystle Shafer, Catalin Toma, Alison Galdys
Introduction. Coronary artery stents are an uncommon site for infection. Only a handful of case reports describe this condition, and Staphylococcus aureus is the most frequent pathogen. Although rare, coronary stent infections are associated with a high mortality rate. Case presentation. We describe the case of a 50-year-old man with a past medical history of seven prior meticillin-resistant S. aureus (MRSA) infections over the previous 12 months, who presented with fever and was found to have persistent MRSA bacteraemia...
September 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29114175/head-to-head-comparison-of-68-ga-citrate-and-18-f-fdg-pet-ct-for-detection-of-infectious-foci-in-patients-with-staphylococcus-aureus-bacteraemia
#17
Soile P Salomäki, Jukka Kemppainen, Ulla Hohenthal, Pauliina Luoto, Olli Eskola, Pirjo Nuutila, Marko Seppänen, Laura Pirilä, Jarmo Oksi, Anne Roivainen
Purpose: This study evaluated the potential of (68)Ga-citrate positron emission tomography/computed tomography (PET/CT) for the detection of infectious foci in patients with Staphylococcus aureus bacteraemia by comparing it with 2-[(18)F]fluoro-2-deoxy-D-glucose ((18)F-FDG) PET/CT. Methods: Four patients admitted to hospital due to S. aureus bacteraemia underwent both (18)F-FDG and (68)Ga-citrate whole-body PET/CT scans to detect infectious foci. Results: The time from hospital admission and the initiation of antibiotic treatment to the first PET/CT was 4-10 days...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29110928/direct-bacterial-identification-from-positive-blood-cultures-using-matrix-assisted-laser-desorption-ionization-time-of-flight-maldi-tof-mass-spectrometry-a-systematic-review-and-meta-analysis
#18
Jesús Ruiz-Aragón, Mónica Ballestero-Téllez, Belén Gutiérrez-Gutiérrez, Marina de Cueto, Jesús Rodríguez-Baño, Álvaro Pascual
INTRODUCTION: The rapid identification of bacteraemia-causing pathogens could assist clinicians in the timely prescription of targeted therapy, thereby reducing the morbidity and mortality of this infection. In recent years, numerous techniques that rapidly and directly identify positive blood cultures have been marketed, with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) being one of the most commonly used. METHODS: The aim of this systematic review and meta-analysis was to evaluate the accuracy of MALDI-TOF (Bruker(®)) for the direct identification of positive blood culture bottles...
October 27, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29105519/staphylococcus-aureus-bacteraemia-and-endocarditis-epidemiology-and-outcome-a-review
#19
Hilmir Asgeirsson, Anders Thalme, Ola Weiland
PURPOSE: To review the epidemiology of Staphylococcus aureus bacteraemia (SAB) and endocarditis (SAE), and discuss the short- and long-term outcome.  Materials and methods: A literature review of the epidemiology of SAB and SAE. RESULTS: The reported incidence of SAB in Western countries is 16-41/100,000 person-years. Increasing incidence has been observed in many regions, in Iceland by 27% during 1995-2008. The increase is believed to depend on changes in population risk factors and possibly better and more frequent utilization of diagnostic procedures...
November 6, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29092707/determining-the-contribution-of-em-streptococcus-pneumoniae-em-to-community-acquired-pneumonia-in-australia
#20
REVIEW
J Kevin Yin, Sanjay H Jayasinghe, Patrick G Charles, Catherine King, Clayton K Chiu, Robert I Menzies, Peter B McIntyre
OBJECTIVE: To evaluate trends in the proportion and severity of community-acquired pneumonia (CAP) attributable to Streptococcus pneumoniae (pneumococcus) in Australians aged 18 years and over. STUDY DESIGN: Systematic review with unpublished data from the largest study. DATA SOURCES: Multiple key bibliographic databases to June 2016. STUDY SELECTION: Australian studies on the aetiology of CAP in adults. DATA SYNTHESIS: In the 12 studies identified, pneumococcus was the most common cause of CAP...
November 6, 2017: Medical Journal of Australia
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