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preventive measure for adhesive intestinal obstruction

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https://www.readbyqxmd.com/read/26879910/injectable-pullulan-hydrogel-for-the-prevention-of-postoperative-tissue-adhesion
#1
Sumi Bang, Eungjae Lee, Young-Gwang Ko, Won Il Kim, Oh Hyeong Kwon
Methods for reducing and preventing postoperative abdominal adhesions have been researched for decades; however, despite these efforts, the formation of postoperative peritoneal adhesions is continuously reported. Adhesions cause serious complications such as postoperative pain, intestinal obstruction, and infertility. Tissue adhesion barriers have been developed as films, membranes, knits, sprays, and hydrogels. Hydrogels have several advantages when used as adhesion barriers, including flexibility, low tissue adhesiveness, biodegradability, and non-toxic degraded products...
June 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/26850207/ghrelin-ameliorates-adhesions-in-a-postsurgical-mouse-model
#2
Enrica Bianchi, Kim Boekelheide, Mark Sigman, Dolores J Lamb, Susan J Hall, Kathleen Hwang
BACKGROUND: Peritoneal adhesion formation is a well-recognized consequence of abdominal and pelvic surgery, causing infertility, chronic pelvic pain, and intestinal obstruction. We hypothesized that ghrelin, a 28-amino acid peptide predominantly found in the stomach, plays an important role in preventing postoperative surgical adhesions. The purpose of this study was to develop a new surgical peritoneal adhesion model to define the role that ghrelin plays in wound healing and adhesion formation...
March 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/25575539/intraperitoneal-administration-of-activated-protein-c-prevents-postsurgical-adhesion-band-formation
#3
Peyman Dinarvand, Seyed Mahdi Hassanian, Hartmut Weiler, Alireza R Rezaie
Postsurgical peritoneal adhesion bands are the most important causes of intestinal obstruction, pelvic pain, and female infertility. In this study, we used a mouse model of adhesion and compared the protective effect of activated protein C (APC) to that of the Food and Drug Administration-approved antiadhesion agent, sodium hyaluronate/carboxymethylcellulose (Seprafilm) by intraperitoneal administration of either APC or Seprafilm to experimental animals. Pathological adhesion bands were graded on day 7, and peritoneal fluid concentrations of tissue plasminogen activator (tPA), d-dimer, thrombin-antithrombin complex, and cytokines (IL-1β, IL-6, interferon-γ, tumor necrosis factor-α, transforming growth factor-β1) were evaluated...
February 19, 2015: Blood
https://www.readbyqxmd.com/read/24772146/spectrum-of-pathologies-in-cases-of-intestinal-obstruction-perforation-based-on-histopathological-examination-of-resected-intestine-report-from-a-third-world-country
#4
Noshin Wasim Yusuf, Sehr Iqbal, Rahat Sarfraz, Shezada Khalid Sohail, Mohammad Imran
BACKGROUND AND OBJECTIVE: Cases presenting with intestinal perforation and obstruction constitute a substantial work load on our surgical service. Etiologies vary in underdeveloped and developed countries. Histopathological examination of resected intestine is expected to provide the definite evidence of the underlying etiology- guiding a better health care planning for preventive measures. Our objective was to study the spectrum of histopathological findings in resected intestines from cases of intestinal obstruction and perforation in our local population to document the underlying etiology...
March 2014: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/23847671/assessment-of-adhesion-formation-after-laparoscopic-intraperitoneal-implantation-of-dynamesh-ipom-mesh
#5
Andrzej Jamry, Marek Jałyński, Lukasz Piskorz, Marian Brocki
INTRODUCTION: Formation of adhesions after laparoscopic hernia repair using the intra-peritoneal onlay mesh (IPOM) procedure can lead to intestinal obstruction or mesh erosion into intestinal lumen. The aims of this study included: measurement of adhesion formation with Dynamesh IPOM after laparoscopic intraperitoneal implantation, and assessment of the occurrence of isolated adhesions at the fastening sites of slowly absorbable sutures. MATERIAL AND METHODS: Twelve healthy pigs underwent laparoscopic implantation of 2 Dynamesh IPOM mesh fragments each, one was fastened with PDSII, and the other with Maxon sutures...
June 20, 2013: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/22912548/effects-of-lactobacillus-plantarum-on-gut-barrier-function-in-experimental-obstructive-jaundice
#6
Yu-Kun Zhou, Huan-Long Qin, Ming Zhang, Tong-Yi Shen, Hong-Qi Chen, Yan-Lei Ma, Zhao-Xin Chu, Peng Zhang, Zhi-Hua Liu
AIM: To investigate the mechanisms of Lactobacillus plantarum (L. plantarum) action on gut barrier in preoperative and postoperative experimental obstructive jaundice in rats. METHODS: Forty rats were randomly divided into groups of sham-operation, bile duct ligation (BDL), BDL + L. plantarum, BDL + internal biliary drainage (IBD), and BDL + IBD + L. plantarum. Ten days after L. plantarum administration, blood and ileal samples were collected from the rats for morphological examination, and intestinal barrier function, liver function, intestinal oxidative stress and protein kinase C (PKC) activity measurement...
August 14, 2012: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/21963510/comparison-of-the-effects-of-pantethine-and-fursultiamine-on-plasma-gastrointestinal-peptide-levels-in-healthy-volunteers
#7
Yosuke Suzuki, Hiroki Itoh, Tomohide Abe, Fumihiro Nishimura, Yuhki Sato, Masaharu Takeyama
Pantethine and fursultiamine have been evaluated for their clinical usefulness in the treatment and prevention of uncomplicated postoperative adhesive intestinal obstruction. In recent years, the actions of drugs used to treat gastrointestinal diseases have been elucidated pharmacologically from the viewpoints of gastrointestinal peptide levels. We examined the effects of pantethine and fursultiamine on plasma levels of calcitonin gene-related peptide (CGRP)-, vasoactive intestinal polypeptide (VIP)-, motilin- and substance P (SP)-like immunoreactive substances (IS) in healthy subjects...
2011: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/19686418/melatonin-prevents-peritoneal-adhesions-in-rats
#8
Nail Ersoz, Mehmet Ozler, Ozcan Altinel, Serdar Sadir, Ismail Hakki Ozerhan, Bulent Uysal, Turgut Topal, Ahmet Guven, Ahmet Korkmaz
BACKGROUND AND AIM: Intra-abdominal adhesions are important postoperative complications following abdominal surgery. The adhesions that develop form the basis of more advanced pathology such as intestinal obstruction or infertility. Melatonin is secreted from the pineal gland in a circadian pattern; this molecule has potent antioxidant characteristics and has beneficial effects in many models of inflammation. The aim of this study was to evaluate the effects of melatonin on peritoneal adhesions created in rats...
November 2009: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/18358285/the-incidence-and-morbidity-of-adhesions-after-treatment-of-neonates-with-gastroschisis-and-omphalocele-a-30-year-review
#9
REVIEW
Floortje C van Eijck, Rene M H Wijnen, Harry van Goor
BACKGROUND/PURPOSE: Adhesive small bowel obstruction (SBO) is a feared complication after correction of abdominal wall defects in neonates. Knowledge of its incidence and potential risk factors in a well-documented group with strict follow-up is needed to guide preventive measures. METHODS: Records of 170 neonates with abdominal wall defects, 59 gastroschisis (GS) and 111 omphalocele (OC), were reviewed focusing on SBO. Risk of SBO was calculated, and potential risk factors were analyzed...
March 2008: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/17097723/prevention-of-adhesion-formation-after-radical-hysterectomy-using-a-sodium-hyaluronate-carboxymethylcellulose-ha-cmc-barrier-a-cost-effectiveness-analysis
#10
Robert E Bristow, Antonio Santillan, Teresa P Diaz-Montes, Ginger J Gardner, Robert L Giuntoli, Susan T Peeler
OBJECTIVE: To evaluate the cost-effectiveness of an adhesion prevention strategy compared to routine care, in which no adhesion prevention measures are taken, through a decision analysis model in the clinical setting of patients undergoing radical hysterectomy and pelvic lymphadenectomy for Stage IB cervical cancer. METHODS: A decision analysis model compared two strategies to manage the risk of adhesion-related morbidity following radical hysterectomy for Stage IB cervical cancer: (1) routine care with no adhesion prevention measures, and (2) the intervention strategy with a HA-CMC anti-adhesion barrier...
March 2007: Gynecologic Oncology
https://www.readbyqxmd.com/read/16378269/the-effect-of-recombinant-growth-hormone-on-intestinal-anastomotic-wound-healing-in-rats-with-obstructive-jaundice
#11
Mehmet Cağlikülekçi, Necdet Ozçay, Taner Oruğ, Gülden Aydoğ, Nurten Renda, Fuat Atalay
BACKGROUND/AIMS: Several clinical and experimental studies have shown that obstructive jaundice delays wound healing. Growth hormone may prevent delayed wound healing, since it has effects on the release of mediators in jaundice, as well as increasing the protein synthesis. METHODS: Forty male Wistar rats were allocated to four groups: Group I (n=10): intestinal anastomosis to normal small bowel, Group II (n=10): intestinal anastomosis to normal small bowel followed by growth hormone therapy (2mg/kg/day, subcutaneously), Group III (n=10): intestinal anastomosis to obstructive jaundice rat's small bowel, Group IV (n=10): intestinal anastomosis to obstructive jaundice rat's small bowel followed by growth hormone therapy at the same dosage The animals were observed for seven days then killed...
March 2002: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/16035380/spectrum-of-causes-of-intestinal-obstruction-in-adult-nigerian-patients
#12
Oladejo O Lawal, Olaniyi S Olayinka, John O Bankole
OBJECTIVE: To present changes in the cause of intestinal obstruction in an African setting. DESIGN: Consecutive cases of acute intestinal obstruction from 1985 to 1994. SETTING: Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria. SUBJECTS: Adult patients with clinical and radiological evidence of intestinal obstruction. RESULTS: There were 99 patients (60 males) aged 15 - 101 years (mean age 45 years)...
May 2005: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/15018747/bowel-obstruction-after-laparoscopic-roux-en-y-gastric-bypass
#13
Ninh T Nguyen, Sergio Huerta, Dmitri Gelfand, C Melinda Stevens, Jeffrey Jim
BACKGROUND: Bowel obstruction has been frequently reported after laparoscopic Roux-en-Y gastric bypass (LRYGBP). The aim of this study was to review our experience with bowel obstruction following LRYGBP, specifically examining its etiology and management and to strategize maneuvers to minimize this complication. METHODS: We retrospectively reviewed the charts of 9 patients who developed postoperative bowel obstruction after LRYGBP. Each chart was reviewed for demographics, timing of bowel obstruction from the primary operation, etiology of obstruction, and management...
February 2004: Obesity Surgery
https://www.readbyqxmd.com/read/12049311/enteral-and-intraluminal-short-chain-fatty-acids-improves-ischemic-left-colonic-anastomotic-healing-in-the-rat
#14
COMPARATIVE STUDY
Omer Topçu, Kürşat Karaday, M Ayhan Kuzu, Suat Ulukent, Bülent Erkek, Iskender Alaçayir
BACKGROUND AND AIMS: This study assessed the effect of short-chain fatty acids (SCFAs) on the healing of ischemic colonic anastomosis and compared the enteral and intraluminal (transrectal) forms of SCFAs in the same study. MATERIAL AND METHODS: Left colonic ischemia was induced and a 1-cm left colon resection 2-4 cm above the peritoneal reflection was performed through a midline incision. In all, 160 rats were divided into eight groups: a control group, an ischemia group, a transrectal SCFAs group, an ischemia + transrectal SCFAs group, an enteral guar gum group, an ischemia + enteral guar gum group, an ischemia + enteral sham group, and a control + enteral sham group...
May 2002: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/11783239/-clinical-study-on-preventive-effect-of-taozhi-zhipu-mixture-on-postoperative-intestinal-adhesion
#15
RANDOMIZED CONTROLLED TRIAL
Y Zhang, B Liang, Z Jiang
OBJECTIVE: To study the clinical effect of Taozhi Zhipu Mixture (TZM) in preventing postoperative intestinal adhesion. METHODS: Three hundred and ninety-six patients who had received abdominal operation were randomly divided into the treated group (188 cases) and the control group (208 cases). Same treatment was given to both groups excepting that the treated group received TZM orally or by nasogastric tube. The time of borborygmus recovering and first passing of flatus-defecation after operation was recorded...
May 1999: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/10810219/evaluation-of-seprafilm-and-amniotic-membrane-as-adhesion-prophylaxis-in-mesh-repair-of-abdominal-wall-hernia-in-rats
#16
A Szabo, M Haj, I Waxsman, A Eitan
INTRODUCTION: Adhesion formation following abdominal wall hernia repair with prosthetic mesh may lead to intestinal obstruction and enterocutaneous fistula. Physical barriers, namely, human amniotic membrane (HAM) or Seprafilm (Genzyme, Cambridge, Mass., USA), a bio-absorbable, translucent membrane composed of carboxymethylcellulose and hyaluronic acid, have been reported to prevent postsurgical intra-abdominal adhesions. OBJECTIVE: Evaluating the effect of HAM and Seprafilm in preventing adhesion formation in the rat model of ventral hernia repair with polypropylene mesh (PPM)...
2000: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/10549754/intestinal-obstruction-after-lung-transplantation-in-children-with-cystic-fibrosis
#17
R K Minkes, J C Langer, M A Skinner, R P Foglia, A O'Hagan, A H Cohen, G B Mallory, C B Huddleston, E N Mendeloff
BACKGROUND/PURPOSE: Distal intestinal obstruction syndrome (DIOS) occurs in 15% of patients with cystic fibrosis (CF). The authors reviewed their experience to determine the incidence, risk factors, and natural history of adhesive intestinal obstruction and DIOS after lung transplantation. METHODS: Eighty-three bilateral transplants were performed in 70 CF patients between January 1990 and September 1998. All were on pancreatic enzymes preoperatively, and none had preoperative bowel preparation...
October 1999: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/10232313/adhesion-related-hospital-readmissions-after-abdominal-and-pelvic-surgery-a-retrospective-cohort-study
#18
H Ellis, B J Moran, J N Thompson, M C Parker, M S Wilson, D Menzies, A McGuire, A M Lower, R J Hawthorn, F O'Brien, S Buchan, A M Crowe
BACKGROUND: Adhesions after abdominal and pelvic surgery are important complications, although their basic epidemiology is unclear. We investigated the frequency of such complications in the general population to provide a basis for the targeting and assessment of new adhesion-prevention measures. METHODS: We used validated data from the Scottish National Health Service medical record linkage database to identify patients undergoing open abdominal or pelvic surgery in 1986, who had no record of such surgery in the preceding 5 years...
May 1, 1999: Lancet
https://www.readbyqxmd.com/read/9290528/prevention-of-adhesions-by-seprafilm-an-absorbable-adhesion-barrier-an-incisional-hernia-model-in-rats
#19
COMPARATIVE STUDY
A Alponat, S R Lakshminarasappa, N Yavuz, P M Goh
Adhesion formation, which is almost inevitable following incisional hernia repair with prosthetic mesh, may lead to intestinal obstruction and enterocutaneous fistulae. Physical barriers, namely carboxymethylcellulose and hyaluronic acid, have been reported to lessen the intra-abdominal adhesions. To evaluate the effects of Seprafilm (Genzyme Corp., Cambridge, MA), a bioresorbable, translucent membrane composed of carboxymethylcellulose and hyaluronic acid, in the presence of a foreign body such as polypropylene mesh, an incisional hernia model in rats was used...
September 1997: American Surgeon
https://www.readbyqxmd.com/read/7634953/-prevention-and-therapy-of-intra-abdominal-adhesions-a-survey-of-1-200-clinics-in-germany
#20
K H Treutner, P Bertram, S Löser, G Winkeltau, V Schumpelick
A survey of 1200 hospitals in Germany was undertaken to estimate the current standards of prevention and treatment of postoperative peritoneal adhesions. The 751 (62.2%) evaluated questionnaires showed a representative distribution according to postal zones and annual laparotomies. The rate of coeliotomies for adhesional bowel obstruction is 2.6%. Starch-powdered gloves are used in 54.2% and washed before operating in 69.3%. Dry swabs and towels are used in 60.7 and 22.5%, respectively. Most of the surgeons suture the peritoneum...
April 1995: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
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