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assisted reproductive technique

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https://www.readbyqxmd.com/read/28333338/drug-discovery-for-male-subfertility-using-high-throughput-screening-a-new-approach-to-an-unsolved-problem
#1
Sarah J Martins da Silva, Sean G Brown, Keith Sutton, Louise V King, Halil Ruso, David W Gray, Paul G Wyatt, Mark C Kelly, Christopher L R Barratt, Anthony G Hope
STUDY QUESTION: Can pharma drug discovery approaches be utilized to transform investigation into novel therapeutics for male infertility? SUMMARY ANSWER: High-throughput screening (HTS) is a viable approach to much-needed drug discovery for male factor infertility. WHAT IS KNOWN ALREADY: There is both huge demand and a genuine clinical need for new treatment options for infertile men. However, the time, effort and resources required for drug discovery are currently exorbitant, due to the unique challenges of the cellular, physical and functional properties of human spermatozoa and a lack of appropriate assay platform...
March 16, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333245/euploidy-rates-in-donor-egg-cycles-significantly-differ-between-fertility-centers
#2
S Munné, M Alikani, L Ribustello, P Colls, Pedro A Martínez-Ortiz, D H McCulloh
STUDY QUESTION: Do external factors affect euploidy in egg donor cycles? SUMMARY ANSWER: The study demonstrates that during human assisted reproduction, embryonic chromosome abnormalities may be partly iatrogenic. WHAT IS KNOWN ALREADY: Chromosome abnormalities have been linked in the past to culture conditions such as temperature and Ph variations, as well as hormonal stimulation. Those reports were performed with older screening techniques (FISH), or ART methods no longer in use, and the subjects studied were not a homogeneous group...
March 2, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333031/new-approaches-regarding-the-in-vitro-maturation-of-oocytes-manipulating-cyclic-nucleotides-and-their-partners-in-crime
#3
REVIEW
Ramon Cesar Botigelli, Eduardo Montanari Razza, Elisa Mariano Pioltine, Marcelo Fábio Gouveia Nogueira
Several discoveries have been described recently (5-10 years) about the biology of ovarian follicles (oocyte, cumulus cells and granulosa cells), including new aspects of cellular communication, the control of oocyte maturation and the acquisition of oocyte competence for fertilization and further embryo development. These advances are nourishing assisted reproduction techniques (ART) with new possibilities, in which novel culture systems are being developed and tested to improve embryo yield and quality. This mini-review aims to describe how the recent knowledge on the physiological aspects of mammalian oocyte is reflecting as original or revisited approaches into the context of embryo production...
February 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28333027/transfer-of-more-than-two-embryos-regardless-of-the-age-of-the-female-partner-is-not-beneficial-for-neither-the-mothers-nor-the-babies-lessons-from-the-latin-american-registry-of-assisted-reproductive-techniques
#4
Juan Enrique Schwarze, Javier Crosby
OBJECTIVE: ART has helped millions of infertile couples worldwide to overcome their childlessness. These successes have been accompanied by an increase in multiple deliveries, and perinatal complications associated. The explanation for this complication is the transfer of more than one embryo, to increase the odds of delivery. Our objective was to compare the outcome of elective dual embryo transfer (eDET) to that of the transfer of more than two embryos without embryo cryopreservation (TET), terms of delivery rate and multiple delivery...
February 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28326521/anxiety-and-depression-in-women-undergoing-infertility-treatment
#5
Paulina Gdańska, Ewa Drozdowicz-Jastrzębska, Barbara Grzechocińska, Maria Radziwon-Zaleska, Piotr Węgrzyn, Mirosław Wielgoś
Infertility is a significant problem for millions of couples. Recently more attention is being paid to the relationship between infertility treatment with the use of Assisted Reproductive Techniques and the presence of mental disturbances, of which anxiety and depression are the most common. We present a review of recent studies evaluating the influence of anxiety and depression on fertility treatment outcomes and the effect of Assisted Reproductive Techniques treatment on the presence of anxiety and depression among women...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28306561/diving-into-the-oocyte-pool
#6
Stine G Kristensen, Susanne E Pors, Claus Y Andersen
PURPOSE OF REVIEW: The ovarian reserve comprises an enormous surplus of follicles. Despite this, some women produce insufficient numbers of oocytes by conventional fertility treatments. However, recent technical accomplishments may transform assisted reproductive technology (ART) in such a way that oocytes are not necessarily the limiting factor. In this review, we present possible new strategies for enhancing the quantity of mature oocytes, and current views on autologous oocytes as potential sources of mitochondria to lift performance of compromised oocytes...
March 16, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28299777/recurrent-vulvovaginal-candidiasis-a-review-of-guideline-recommendations
#7
REVIEW
Alexia Matheson, Danielle Mazza
BACKGROUND: Recurrent vulvovaginal candidiasis (VVC) is a difficult-to-manage condition that affects 5-8% of women of reproductive age. Current treatment regimes have high relapse rates, resulting in poor quality of life for the women affected. AIM: To compare the quality and content of current guidelines concerned with recurrent VVC and to develop a summary of recommendations to assist in the management of women with this condition. METHODS: Relevant clinical guidelines were identified through a search of several databases (MEDLINE, SCOPUS and The Cochrane Library) and relevant websites...
March 15, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28298949/first-trimester-diagnosis-of-conjoined-twins-in-a-multifetal-pregnancy-after-assisted-reproduction-technique-using-hdlive-rendering
#8
Pedro Teixeira Castro, Heron Werner, Edward Araujo Júnior
No abstract text is available yet for this article.
March 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28296254/short-term-fsh-treatment-and-sperm-maturation-a-prospective-study-in-idiopathic-infertile-men
#9
E Casamonti, S Vinci, E Serra, M G Fino, S Brilli, F Lotti, M Maggi, M E Coccia, G Forti, C Krausz
The standard FSH treatment is based on a 3 months period, after which both quantitative/qualitative improvement of sperm parameters and increased pregnancy rate were reported. In this prospective clinical trial, for the first time, we studied (i) Sperm hyaluronic acid binding capacity after highly purified FSH (hpFSH) treatment; (ii) the effect after short-term and standard treatment on this functional parameter. As secondary objective, we analyzed three SNPs on FSHβ and FSHR genes to define their potential predictive value for responsiveness...
March 15, 2017: Andrology
https://www.readbyqxmd.com/read/28293053/effect-of-melatonin-on-the-outcome-of-assisted-reproductive-technique-cycles-in-women-with-diminished-ovarian-reserve-a-double-blinded-randomized-clinical-trial
#10
Bahia Namavar Jahromi, Sara Sadeghi, Shohreh Alipour, Mohammad Ebrahim Parsanezhad, Shaghayegh Moradi Alamdarloo
Diminished ovarian reserve (DOR) significantly decreases the success rate of the assisted reproductive technique (ART). In this study, we assessed the effect of melatonin on the ART outcomes in women with DOR. A double-blinded, randomized, clinical trial was performed on 80 women with DOR as a pilot study in Shiraz, between 2014 and 2015. DOR was defined as the presence of 2 of the following 3 criteria: 1) anti-Müllerian hormone ≤1, 2) follicle-stimulating hormone ≥10, and 3) bilateral antral follicle count ≤6...
January 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28280798/endometrial-expression-of-%C3%AE-3-integrin-calcitonin-and-plexin-b1-in-the-window-of-implantation-in-women-with-unexplained-infertility
#11
Mehran Dorostghoal, Hamid-O-Allah Ghaffari, Nahid Shahbazian, Maryam Mirani
BACKGROUND: Endometrial receptivity plays a key role in the establishment of successful implantation and its impairment may contribute to subfertility and limit the assisted reproduction techniques (ART) success. OBJECTIVE: The aim of present study was to investigate endometrial receptivity in terms of β3 integrin, calcitonin and plexin-B1 expression in women with unexplained infertility. MATERIALS AND METHODS: We evaluated expression of β3 integrin, calcitonin and plexin-B1 through mRNA level measurement with real-time RT-PCR, in the endometrium of 16 infertile women with unexplained infertility and 10 fertile women...
January 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28272511/non-destructive-monitoring-of-mouse-embryo-development-and-its-qualitative-evaluation-at-the-molecular-level-using-raman-spectroscopy
#12
Mika Ishigaki, Kosuke Hashimoto, Hidetoshi Sato, Yukihiro Ozaki
Current research focuses on embryonic development and quality not only by considering fundamental biology, but also by aiming to improve assisted reproduction technologies, such as in vitro fertilization. In this study, we explored the development of mouse embryo and its quality based on molecular information, obtained nondestructively using Raman spectroscopy. The detailed analysis of Raman spectra measured in situ during embryonic development revealed a temporary increase in protein content after fertilization...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28259703/-do-controlled-ovarian-hyperstimulations-and-cryopreservations-promote-recurrences-after-breast-cancer
#13
M-L Bergamini, C M Maugard, C Mathelin
The objective of this review was to identify recurrences (ipsilateral, contralateral, metastases and deaths) occurring after controlled ovarian hyperstimulation (COH) or cryopreservation of ovarian tissue (CPTO) for patients treated for a breast cancer. METHODS: We performed a bibliographical research through the Pubmed/Medline database, including all the references from January 2006 until September 2016, in French or in English, after exclusion of animal studies. The keywords association "breast neoplasms", "fertility preservation", "reproductive techniques", "ovarian cryopreservation" and "in vitro fertilization" allowed the selection of 852 publications among which only 6 were selected because they included data on recurrence and long term follow up...
March 1, 2017: Gynecol Obstet Fertil Senol
https://www.readbyqxmd.com/read/28218964/temporal-trends-in-minimally-invasive-myomectomy-before-and-after-the-us-food-and-drug-administration-recommendation-against-electric-morcellation
#14
Nigel Pereira, William C Frankel, Anne P Hutchinson, Hency H Patel, Cheri Mostisser, Rony T Elias
OBJECTIVE: To investigate the temporal trends in minimally invasive myomectomy at one reproductive medicine center before and after the US Food and Drug Administration (FDA) recommendation against electric morcellation. METHODS: A retrospective chart review was undertaken of patients undergoing minimally invasive myomectomy between April 1, 2012, and April 30, 2016, at a center in New York. Temporal trends in laparoscopic myomectomy (LM), robot-assisted laparoscopic myomectomy (RAM), and laparoscopically assisted myomectomy (LAM), and intraoperative and postoperative outcomes before and after the April 2014 recommendation were compared...
February 20, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28216918/spontaneous-conception-in-40-year-old-infertile-woman-with-polycystic-ovaries-after-complete-reversal-of-endometrial-intraepithelial-neoplasia-a-case-report-with-review-of-literature
#15
Swati Verma, Umesh N Jindal
We report a case of polycystic ovary syndrome and prolonged infertility in which endometrial intraepithelial neoplasia was reversed with high dose progesterone therapy. Spontaneous conception after failure of assisted reproductive techniques highlights the role of endometrial receptivity.
October 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28208945/perinatal-outcome-of-second-twin-with-respect-to-mode-of-delivery-an-observational-study
#16
Rujul Rashmin Jhaveri, Trupti K Nadkarni
INTRODUCTION: With the advent of assisted reproductive techniques, multi-fetal pregnancies are on the rise. While caesarean section is the defined mode of delivery for triplets and higher order pregnancies, the picture for twin delivery is not so clear. While a trial for vaginal delivery is attempted, the second twin is considered vulnerable to complications. Whether this translates into worsened perinatal outcomes is not well defined. AIM: To study the perinatal outcome and to identify the various factors influencing the perinatal outcome of second twin with respect to mode of delivery...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28186636/triplet-pregnancy-from-the-transfer-of-two-blastocysts-demonstrating-a-twin-reversed-arterial-perfusion-sequence-with-a-conjoined-twins-pump-fetus
#17
Hongxia Yuan, Qichang Zhou, Jing Li, Shi Zeng
The incidence of monochorionic gestation is increased eight-fold following assisted reproductive techniques [1]. Monochorionic triplet pregnancies are rare, occurring in 1 in 45 500 deliveries [2], and are associated with high mortality and morbidity. Both conjoined twins and the twin reversed arterial perfusion (TRAP) sequence are unique complications of monochorionic pregnancy. The present study describes transvaginal ultrasonography findings from a monochorionic diamniotic triplet pregnancy at 10 weeks of gestation following double embryo transfer; a TRAP sequence, with a pair of conjoined twins as a "pump" fetus was identified...
February 10, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28186620/an-update-on-the-diagnosis-surgical-management-and-fertility-outcomes-for-women-with-endometrioma
#18
REVIEW
Ryan Cranney, George Condous, Shannon Reid
Endometriosis is estimated to affect up to 50% of infertile women, and severity of endometriosis stage appears to correlate with reduced fertility. Ovarian endometriomas are found in up to 44% of women with endometriosis, and are significantly associated with the presence of pelvic deep infiltrating endometriosis, ovarian adhesions, and pouch of Douglas obliteration. Through the use of MEDLINE and PubMed databases, we conducted a literature review of all available research related to the diagnosis, surgical management and fertility outcomes for women with endometrioma...
February 10, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28185121/the-association-between-coenzyme-q10-concentrations-in-follicular-fluid-with-embryo-morphokinetics-and-pregnancy-rate-in-assisted-reproductive-techniques
#19
Süleyman Akarsu, Funda Gode, Ahmet Zeki Isik, Zeliha Günnur Dikmen, Mustafa Agah Tekindağ
PURPOSE: This study seeks to evaluate the association between follicular fluid (FF) coenzyme Q10 (CoQ10) levels, embryo morphokinetics, and pregnancy rate. METHODS: Sixty infertile patients who underwent intracytoplasmic sperm injection (ICSI) cycles were included in the study. For each patient, CoQ10 level of the follicular fluid was measured by high-performance liquid chromatography system. After the ICSI of each oocyte, the relationship between the level of CoQ10 content of each follicular fluid, the subsequent embryo quality, and embryo morphokinetics was investigated...
February 9, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28179045/analysis-of-polymorphism-rs1042522-in-tp53-gene-in-the-mothers-of-twins-and-of-singletons-a-population-based-study-in-rio-grande-do-sul-brazil
#20
Ana C Mardini, Fernanda S Pereira, Lavínia Schuler-Faccini, Ursula Matte
Although the birth of twins has always attracted attention, there are no known genetic or environmental factors that can determine the birth of monozygotic (MZ) twins. And even for dizygotic (DZ) twins, genetic influences are not completely understood. A previous study from our group has shown that the C allele of polymorphism rs1042522 in the TP53 gene was more frequent in the mothers of twins than in the mothers of singletons in a small village in South Brazil. In order to clarify whether this was an isolated factor, we performed a population-based, observational case-control study...
February 9, 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
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