keyword
MENU ▼
Read by QxMD icon Read
search

Mitochondria glutathione

keyword
https://www.readbyqxmd.com/read/27904687/high-fructose-causes-cardiac-hypertrophy-via-mitochondrial-signaling-pathway
#1
Yan-Bo Zhang, Yan-Hai Meng, Shuo Chang, Rong-Yuan Zhang, Chen Shi
High fructose diet can cause cardiac hypertrophy and oxidative stress is a key mediator for myocardial hypertrophy. Disruption of cystic fibrosis transmembrane conductance regulator (CFTR) leads to oxidative stress. This study aims to reveal mitochondrial oxidative stress-related signaling pathway in high fructose-induced cardiac hypertrophy. Mice were fed high fructose to develop cardiac hypertrophy. Fructose and H2O2 were used to induce cardiomyocyte hypertrophy in vitro. Mitochondria-targeted antioxidant SkQ1 was applied to investigate the possible role of mitochondrial reactive oxygen species (ROS)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27896503/effect-of-pgc-1%C3%AE-overexpression-or-silencing-on-mitochondrial-apoptosis-of-goat-luteinized-granulosa-cells
#2
Guo-Min Zhang, Ming-Tian Deng, Yan-Li Zhang, Yi-Xuan Fan, Yong-Jie Wan, Hai-Tao Nie, Zi-Yu Wang, Feng Wang, Zhi-Hai Lei
During goat follicular development, abnormal expression of peroxisome proliferator- activated receptor gamma coactivator-1 alpha (PGC-1α) in granulosa cells (GCs) may contribute to follicular atresia with unknown regulatory mechanisms. In this study, we investigate the effect of ectopic expression or interference of PGC-1α on cell apoptosis of goat first passage granulosa cells (FGCs) in vitro. The results indicate that PGC-1α silencing by short hairpin RNA (shRNA) in goat FGCs significantly reduced mitochondrial DNA (mtDNA) copy number (P < 0...
November 28, 2016: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/27890358/nucleo-mitochondrial-interaction-of-yeast-in-response-to-cadmium-sulfide-quantum-dot-exposure
#3
Francesco Pasquali, Caterina Agrimonti, Luca Pagano, Andrea Zappettini, Marco Villani, Marta Marmiroli, Jason C White, Nelson Marmiroli
Cell sensitivity to quantum dots (QDs) has been attributed to a cascade triggered by oxidative stress leading to apoptosis. The role and function of mitochondria in animal cells are well understood but little information is available on the complex genetic networks that regulate nucleo-mitochondrial interaction. The effect of CdS QD exposure in yeast Saccharomyces cerevisiae was assessed under conditions of limited lethality (<10%), using cell physiological and morphological endpoints. Whole-genomic array analysis and the screening of a deletion mutant library were also carried out...
November 19, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27879375/the-role-of-oxidative-stress-in-koenimbine-induced-dna-damage-and-heat-shock-protein-modulation-in-hepg2-cells
#4
Yahya Hasan Hobani
Murraya koenigii (L.) Spreng, is a significant herb of traditional Ayurvedic system of medicine. Koenimbine, a carbazole alkaloid isolated from this plant holds antiproliferative and apoptotic effects. The aim of this study was to assess koenimbine-induced DNA damage and to clarify the role of free radicals in cell death mechanisms, using HepG2 cells. Methods The level of cytotoxicity was assayed by MTT assay. To elucidate the role of glutathione (GSH), the intracellular GSH level was analyzed. The effect of koenimbine in the cell mitochondria was evaluated using mitochondrial membrane potential (MMP) changes...
November 21, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27875592/curcumin-generates-oxidative-stress-and-induces-apoptosis-in-adult-schistosoma-mansoni-worms
#5
Daniela de Paula Aguiar, Mayara Brunetto Moreira Moscardini, Enyara Rezende Morais, Renato Graciano de Paula, Pedro Manuel Ferreira, Ana Afonso, Silvana Belo, Amanda Tomie Ouchida, Carlos Curti, Wilson Roberto Cunha, Vanderlei Rodrigues, Lizandra Guidi Magalhães
Inducing apoptosis is an interesting therapeutic approach to develop drugs that act against helminthic parasites. Researchers have investigated how curcumin (CUR), a biologically active compound extracted from rhizomes of Curcuma longa, affects Schistosoma mansoni and several cancer cell lines. This study evaluates how CUR influences the induction of apoptosis and oxidative stress in couples of adult S. mansoni worms. CUR decreased the viability of adult worms and killed them. The tegument of the parasite suffered morphological changes, the mitochondria underwent alterations, and chromatin condensed...
2016: PloS One
https://www.readbyqxmd.com/read/27867086/diazoxide-prevents-reactive-oxygen-species-and-mitochondrial-damage-leading-to-anti-hypertrophic-effects
#6
Aline M Lucas, Francisco R Caldas, Amanda P da Silva, Maximiano M Ventura, Iago M Leite, Ana B Filgueiras, Claúdio G L Silva, Alicia J Kowaltowski, Heberty T Facundo
Pathological cardiac hypertrophy is characterized by wall thickening or chamber enlargement of the heart in response to pressure or volume overload, respectively. This condition will, initially, improve the organ contractile function, but if sustained will render dysfunctional mitochondria and oxidative stress. Mitochondrial ATP-sensitive K(+) channels (mitoKATP) modulate the redox status of the cell and protect against several cardiac insults. Here, we tested the hypothesis that mitoKATP opening (using diazoxide) will avoid isoproterenol-induced cardiac hypertrophy in vivo by decreasing reactive oxygen species (ROS) production and mitochondrial Ca(2+)-induced swelling...
November 17, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27864821/effect-of-alterations-in-apoptotic-pathway-on-development-of-metabolic-syndrome-in-patients-with-psoriasis-vulgaris
#7
S Korkmaz, H Korkmaz
OBJECTIVES: The purpose of this study is to evaluate the role of changes in gene expression of apoptosis activators (BAX, cytocrome-c [cyt-c], and caspase-3) and apoptosis inhibitors (BCL2, survivin, cyclin D1 [CCND1], SOD, catalase 3 [CAT], glutathione synthetase [GS], heat shock protein [HSP]27, HSP60, HSP70, and HSP90) on the development of metabolic syndrome (MetS) in patients with psoriasis vulgarins. METHODS: Fifty patients with psoriasis were enrolled in the study, 25 of whom had MetS...
November 18, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27864738/biochemical-and-histological-biomarkers-in-the-midgut-of-apis-mellifera-from-polluted-environment-at-beheira-governorate-egypt
#8
Ahmed M Abu El-Saad, Dalia A Kheirallah, Lamia M El-Samad
The aim of this study was to analyze the impact of organophosphorus (OP) pollutants on oxidative stress and ultrastructural biomarkers in the midgut of the honeybee Apis mellifera collected from three locations that differ in their extent of spraying load with OP insecticides: a weakly anthropised rural site, Bolin which is considered as a reference site; moderately spraying site, El Kaza; and a strongly anthropised urban site, Tiba with a long history of pesticide use. Results showed that high concentrations of chlorpyrifos, malathion, diazinon, chlorpyrifos-methyl, and pirimiphos-methyl were detected in midgut at locations with extensive pesticide spraying...
November 18, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27864377/mitochondrial-and-redox-abnormalities-in-autism-lymphoblastoid-cells-a-sibling-control-study
#9
Shannon Rose, Sirish C Bennuri, Rebecca Wynne, Stepan Melnyk, S Jill James, Richard E Frye
Autism spectrum disorder (ASD) is associated with physiological abnormalities including abnormal redox and mitochondrial metabolism. Lymphoblastoid cell lines (LCLs) from some children with ASD exhibit increased oxidative stress, decreased glutathione redox capacity, and highly active mitochondria with increased vulnerability to reactive oxygen species (ROS). Because unaffected siblings (Sibs) of individuals with ASD share some redox abnormalities, we sought to determine whether LCLs from Sibs share ASD-associated mitochondrial abnormalities...
November 18, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27861548/targeting-mitochondrial-dysfunction-with-l-alpha-glycerylphosphorylcholine
#10
Gerda Strifler, Eszter Tuboly, Anikó Görbe, Mihály Boros, Daniella Pécz, Petra Hartmann
BACKGROUND: We hypothesized that L-alpha-glycerylphosphorylcholine (GPC), a deacylatedphosphatidylcholine derivative, can influence the mitochondrial respiratory activity and in this way, may exert tissue protective effects. METHODS: Rat liver mitochondria were examined with high-resolution respirometry to analyze the effects of GPC on the electron transport chain in normoxic and anoxic conditions. Besides, Sprague-Dawley rats were subjected to sham operation or standardized liver ischemia-reperfusion (IR), with or without GPC administration...
2016: PloS One
https://www.readbyqxmd.com/read/27860296/impact-of-subnormothermic-machine-perfusion-preservation-in-severely-steatotic-rat-livers-a-detailed-assessment-in-an-isolated-setting
#11
Y Okamura, K Hata, H Tanaka, H Hirao, T Kubota, O Inamoto, S Kageyama, I Tamaki, N Yermek, J Yoshikawa, S Uemoto
Current drastic shortage of donor organs has led to acceptance of extended-criteria donors for transplantation, despite higher risk of primary non-function. Here, we report the impact of subnormothermic machine perfusion (SMP) preservation on the protection of >50% macro-steatotic livers. Dietary hepatic steatosis was induced in Wistar rats via 2-day fasting and subsequent 3-day re-feeding with a fat-free, carbohydrate-rich diet. This protocol induces 50-60% macrovesicular steatosis, which should be discarded when preserved via cold storage (CS)...
November 10, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27858292/cisplatin-toxicity-in-dorsal-root-ganglion-neurons-is-relieved-by-meclizine-via-diminution-of-mitochondrial-compromise-and-improved-clearance-of-dna-damage
#12
Murat F Gorgun, Ming Zhuo, Ella W Englander
Chemotherapy-induced neurotoxicity of peripheral nervous system (PNS) hinders efficacy of cancer treatments. Mechanisms initiating PNS injury by anticancer drugs are incompletely understood delaying development of effective management strategies. To understand events triggered in PNS by cancer drugs, we exposed dorsal root ganglion (DRG) neurons to cisplatin, a drug from platinum-based class of chemotherapeutics frequently implicated in peripheral neuropathies. While cisplatin enters cancer cells and forms cisplatin/DNA crosslinks that block cell proliferation, circulating cisplatin can also reach the PNS and produce crosslinks that impede critical DNA transactions in postmitotic neurons...
November 17, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27848206/tanshinone-i-attenuates-the-effects-of-a-challenge-with-h2o2-on-the-functions-of-tricarboxylic-acid-cycle-and-respiratory-chain-in-sh-sy5y-cells
#13
Marcos Roberto de Oliveira, Cristina Ribas Fürstenau, Izabel Cristina Custódio de Souza, Gustavo da Costa Ferreira
Tanshinone I (T-I; C18H12O3) is a cytoprotective molecule. T-I has been viewed as an antioxidant and anti-inflammatory agent exerting neuroprotective actions in several experimental models. Nonetheless, the mechanisms underlying the beneficial effects of T-I in mammalian cells are not completely understood yet. Mitochondrial dysfunction has been associated with several neurodegenerative diseases which remain uncured. Therefore, there is increasing interest in compounds that may be used in the prevention or treatment of those pathologies...
November 15, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27830689/-isomerization-of-asp7-increases-the-toxic-effects-of-amyloid-%C3%AE-and-its-phosphorylated-form-in-sh-sy5y-neuroblastoma-cells
#14
E P Barykin, I Yu Petrushanko, K M Burnysheva, A A Makarov, V A Mitkevich
The generation of amyloid β (Aβ) toxic oligomers during the formation of senile plaques and amyloid fibrils is thought to play a central role in the onset and progression of Alzheimer's disease. Aβ production is a physiological process, but the factors that trigger a transition to pathogenic Aβ aggregation remain unknown. Posttranslational modifications of Aβ could potentially induce the transition. The effects of Aβ and its modified forms containing isomerized Asp7, phosphorylated Ser8, or both, were studied in SH-SY5Y human neuroblastoma cells...
September 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/27810734/the-mitochondria-targeted-antioxidant-mitoq-modulates-oxidative-stress-inflammation-and-leukocyte-endothelium-interactions-in-leukocytes-isolated-from-type-2-diabetic-patients
#15
Irene Escribano-Lopez, Noelia Diaz-Morales, Susana Rovira-Llopis, Arantxa Martinez de Marañon, Samuel Orden, Angeles Alvarez, Celia Bañuls, Milagros Rocha, Michael P Murphy, Antonio Hernandez-Mijares, Victor M Victor
It is not known if the mitochondria-targeted antioxidants such as mitoquinone (MitoQ) can modulate oxidative stress and leukocyte-endothelium interactions in T2D patients. We aimed to evaluate the beneficial effect of MitoQ on oxidative stress parameters and leukocyte-endothelium interactions in leukocytes of T2D patients. The study population consisted of 98 T2D patients and 71 control subjects. We assessed metabolic and anthropometric parameters, mitochondrial reactive oxygen species (ROS) production, glutathione peroxidase 1 (GPX-1), NFκB-p65, TNFα and leukocyte-endothelium interactions...
October 27, 2016: Redox Biology
https://www.readbyqxmd.com/read/27799181/mitovite-a-mitochondria-targeted-antioxidant-limits-paclitaxel-induced-oxidative-stress-and-mitochondrial-damage-in-vitro-and-paclitaxel-induced-mechanical-hypersensitivity-in-a-rat-pain-model
#16
B McCormick, D A Lowes, L Colvin, C Torsney, H F Galley
BACKGROUND: Neuropathic pain is a common side-effect of chemotherapy. Although precise mechanisms are unclear, oxidative stress and mitochondrial damage are involved. We investigated whether the mitochondria targeted antioxidant, MitoVitE, provided better protection against paclitaxel-induced mitochondrial damage in rat dorsal root ganglion (DRG) cells, than a non-targeted form of vitamin E, Trolox. We also determined whether MitoVitE, compared with duloxetine, could limit paclitaxel-induced mechanical hypersensitivity in rats...
November 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27773698/differential-susceptibility-to-acetaminophen-induced-liver-injury-in%C3%A2-sub-strains-of-c57bl-6-mice-6n-versus-6j
#17
Luqi Duan, John S Davis, Benjamin L Woolbright, Kuo Du, Mala Cahkraborty, James Weemhoff, Hartmut Jaeschke, Mohammed Bourdi
: Mouse models of acetaminophen (APAP) hepatotoxicity are considered relevant for the human pathophysiology. The C57BL/6 strain is most popular because it is the background strain of gene knock-out mice. However, conflicting results in the literature may have been caused by sub-strain mismatches, e.g. C57BL/6J and C57BL/6N. This study was initiated to determine the mechanism behind the sub-strain susceptibility to APAP toxicity. C57BL/6N and C57BL/6J mice were dosed with 200 mg/kg APAP and sacrificed at different time points...
December 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27771118/puerarin-ameliorates-heat-stress-induced-oxidative-damage-and-apoptosis-in-bovine-sertoli-cells-by-suppressing-ros-production-and-upregulating-hsp72-expression
#18
Xia Cong, Qian Zhang, Huatao Li, Zhongling Jiang, Rongfeng Cao, Shansong Gao, Wenru Tian
Puerarin, a bioactive isoflavone glucoside extracted from radix Puerariae, has been proven to possess many biological activities. However, the role of puerarin in protecting bovine Sertoli cells (bSCs) under heat stress conditions remains to be clarified. The present study aimed to explore the possible protective mechanism of puerarin for primary cultured bSCs subjected to heat stress. Bovine Sertoli cells were treated with 15 μM of puerarin before they were exposed to 42 °C for 1 hour. The dose of puerarin (15 μM) was determined on the basis of cell viability...
January 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/27760377/therapeutic-relevance-of-mtor-inhibition-in-murine-succinate-semialdehyde-dehydrogenase-deficiency-ssadhd-a-disorder-of-gaba-metabolism
#19
K R Vogel, G R Ainslie, E E W Jansen, G S Salomons, K M Gibson
Aldehyde dehydrogenase 5a1-deficient (aldh5a1(-/-)) mice, the murine orthologue of human succinic semialdehyde dehydrogenase deficiency (SSADHD), manifest increased GABA (4-aminobutyric acid) that disrupts autophagy, increases mitochondria number, and induces oxidative stress, all mitigated with the mTOR (mechanistic target of rapamycin) inhibitor rapamycin [1]. Because GABA regulates mTOR, we tested the hypothesis that aldh5a1(-/-) mice would show altered levels of mRNA for genes associated with mTOR signaling and oxidative stress that could be mitigated by inhibiting mTOR...
October 17, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27718046/the-role-of-ca-2-imbalance-in-the-induction-of-acute-oxidative-stress-and-cytotoxicity-in-cultured-rat-cerebellar-granule-cells-challenged-with-tetrabromobisphenol-a
#20
Elzbieta Zieminska, Jacek Lenart, Dominik Diamandakis, Jerzy W Lazarewicz
Using primary cultures of rat cerebellar granule cells (CGC) we examined the role of calcium transients induced by tetrabromobisphenol A (TBBPA) in triggering oxidative stress and cytotoxicity. CGC were exposed for 30 min to 10 or 25 µM TBBPA. Changes in intracellular calcium concentration ([Ca(2+)]i), in the production of reactive oxygen species (ROS), and in the potential of mitochondria (∆Ψm) were measured fluorometrically during the exposure. The intracellular glutathione (GSH) and catalase activity were determined after the incubation; cell viability was evaluated 24 h later...
October 7, 2016: Neurochemical Research
keyword
keyword
104855
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"