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Mitochondria glutathione

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https://www.readbyqxmd.com/read/28223107/olfactory-bulbectomy-in-mice-triggers-transient-and-long-lasting-behavioral-impairments-and-biochemical-hippocampal-disturbances
#1
Roberto Farina de Almeida, Marcelo Ganzella, Daniele Guilhermano Machado, Samanta Oliveira Loureiro, Douglas Leffa, André Quincozes-Santos, Letícia Ferreira Pettenuzzo, Marta Maria Medeiros Frescura Duarte, Thiago Duarte, Diogo Onofre Souza
Major depressive disorder (MDD) is a neuropsychiatric disease that is associated with profound disturbances in affected individuals. Elucidating the pathophysiology of MDD has been frustratingly slow, especially concerning the neurochemical events and brain regions associated with disease progression. Thus, we evaluated the time-course (up to 8weeks) behavioral and biochemical effects in mice that underwent to a bilateral olfactory bulbectomy (OBX), which is used to modeling depressive-like behavior in rodents...
February 18, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28219698/protective-effects-of-diallyl-disulfide-against-acetaminophen-induced-nephrotoxicity-a-possible-role-of-cyp2e1-and-nf-%C3%AE%C2%BAb
#2
Je-Won Ko, Jin-Young Shin, Jeong-Won Kim, Sung-Hyeuk Park, Na-Rae Shin, In-Chul Lee, In-Sik Shin, Changjong Moon, Sung-Ho Kim, Sung-Hwan Kim, Jong-Choon Kim
Diallyl disulfide (DADS) is a degradation product of allicin which is contained in garlic. This study investigated the protective effects of DADS against acetaminophen (AAP)-induced nephrotoxicity and the molecular mechanisms of nephroprotective effects in rats. AAP caused severe nephrotoxicity as evidenced by significant increases in renal tubular cell apoptosis, mitochondria-mediated apoptosis, and up-regulation of nuclear transcription factor kappa-B (NF-κB), cyclooxygenase-2 (Cox-2), and tumor necrosis factor-α (TNF-α) in the kidney with histopathological alterations...
February 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28216050/vancomycin-induces-reactive-oxygen-species-dependent-apoptosis-via-mitochondrial-cardiolipin-peroxidation-in-renal-tubular-epithelial-cells
#3
Yuya Sakamoto, Takahisa Yano, Yuki Hanada, Aki Takeshita, Fumika Inagaki, Satohiro Masuda, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo
Vancomycin (VCM) is a first-line antibiotic for serious infections caused by methicillin-resistant Staphylococcus aureus. However, nephrotoxicity is one of the most complaint in VCM therapy. We previously reported that VCM induced apoptosis in a porcine proximal tubular epithelial cell line (LLC-PK1), in which mitochondrial complex I may generate superoxide, leading to cell death. In the present study, VCM caused production of mitochondrial reactive oxygen species and peroxidation of the mitochondrial phospholipid cardiolipin that was reversed by administration of the mitochondrial uncoupler carbonyl cyanide-4-(trifluoromethoxy) phenylhydrazone (FCCP)...
February 16, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28215674/effect-of-vitrification-on-meiotic-maturation-mitochondrial-distribution-and-glutathione-synthesis-in-immature-silver-fox-cumulus-oocyte-complexes
#4
Xinyan Cao, Jingchun Li, Hailong Xue, Shiyong Wang, Weigang Zhao, Zhanyu Du, Yifeng Yang, Zhigang Yue
The present study was designed to investigate the effects of vitrifying oocytes obtained from silver foxes on nuclear maturation, mitochondrial distribution and glutathione (GSH) synthesis after in vitro culture for 72 h. Immature oocytes were randomly divided into three groups: (1) fresh GV (germinal vesicle) oocytes (Control group), (2) exposure to the equilibration and vitrification solution but without being plunged into liquid nitrogen (exposed group), and (3) vitrification by the cryoloop method (vitrified-warmed group)...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28214972/avocado-oil-induces-long-term-alleviation-of-oxidative-damage-in-kidney-mitochondria-from-type-2-diabetic-rats-by-improving-glutathione-status
#5
Omar Ortiz-Avila, María Del Consuelo Figueroa-García, Claudia Isabel García-Berumen, Elizabeth Calderón-Cortés, Jorge A Mejía-Barajas, Alain R Rodriguez-Orozco, Ricardo Mejía-Zepeda, Alfredo Saavedra-Molina, Christian Cortés-Rojo
Hyperglycemia and mitochondrial ROS overproduction have been identified as key factors involved in the development of diabetic nephropathy. This has encouraged the search for strategies decreasing glucose levels and long-term improvement of redox status of glutathione, the main antioxidant counteracting mitochondrial damage. Previously, we have shown that avocado oil improves redox status of glutathione in liver and brain mitochondria from streptozotocin-induced diabetic rats; however, the long-term effects of avocado oil and its hypoglycemic effect cannot be evaluated because this model displays low survival and insulin depletion...
February 18, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28212723/redox-dynamics-of-manganese-as-a-mitochondrial-life-death-switch
#6
REVIEW
Matthew Ryan Smith, Jolyn Fernandes, Young-Mi Go, Dean P Jones
Sten Orrenius, M.D., Ph.D., pioneered many areas of cellular and molecular toxicology and made seminal contributions to our knowledge of oxidative stress and glutathione (GSH) metabolism, organellar functions and Ca(+2)-dependent mechanisms of cell death, and mechanisms of apoptosis. On the occasion of his 80(th) birthday, we summarize current knowledge on redox biology of manganese (Mn) and its role in mechanisms of cell death. Mn is found in all organisms and has critical roles in cell survival and death mechanisms by regulating Mn-containing enzymes such as manganese superoxide dismutase (SOD2) or affecting expression and activity of caspases...
January 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28192232/real-time-quantification-of-subcellular-h2o2-and-glutathione-redox-potential-in-living-cardiovascular-tissues
#7
Emiliano Panieri, Carlo Millia, Massimo M Santoro
Detecting and measuring the dynamic redox events that occur in vivo is a prerequisite for understanding the impact of oxidants and redox events in normal and pathological conditions. These aspects are particularly relevant in cardiovascular tissues wherein alterations of the redox balance are associated with stroke, aging, and pharmacological intervention. An ambiguous aspect of redox biology is how redox events occur in subcellular organelles including mitochondria, and nuclei. Genetically-encoded Rogfp2 fluorescent probes have become powerful tools for real-time detection of redox events...
February 10, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28183062/thioredoxin-trxo1-interacts-with-proliferating-cell-nuclear-antigen-pcna-and-its-overexpression-affects-the-growth-of-tobacco-cell-culture
#8
Aingeru Calderón, Ana Ortiz-Espín, Raquel Iglesias-Fernández, Pilar Carbonero, Federico Vicente Pallardó, Francisca Sevilla, Ana Jiménez
Thioredoxins (Trxs), key components of cellular redox regulation, act by controlling the redox status of many target proteins, and have been shown to play an essential role in cell survival and growth. The presence of a Trx system in the nucleus has received little attention in plants, and the nuclear targets of plant Trxs have not been conclusively identified. Thus, very little is known about the function of Trxs in this cellular compartment. Previously, we studied the intracellular localization of PsTrxo1 and confirmed its presence in mitochondria and, interestingly, in the nucleus under standard growth conditions...
January 31, 2017: Redox Biology
https://www.readbyqxmd.com/read/28176145/propofol-attenuates-h2o2-induced-oxidative-stress-and-apoptosis-via-the-mitochondria-and-er-medicated-pathways-in-neonatal-rat-cardiomyocytes
#9
Xue-Ru Liu, Lu Cao, Tao Li, Lin-Lin Chen, Yi-Yan Yu, Wen-Jun Huang, Li Liu, Xiao-Qiu Tan
Previous studies have shown that propofol, an intravenous anesthetic commonly used in clinical practice, protects the myocardium from injury. Mitochondria- and endoplasmic reticulum (ER)-mediated oxidative stress and apoptosis are two important signaling pathways involved in myocardial injury and protection. The present study aimed to test the hypothesis that propofol could exert a cardio-protective effect via the above two pathways. Cultured neonatal rat cardiomyocytes were treated with culture medium (control group), H2O2 at 500 μM (H2O2 group), propofol at 50 μM (propofol group), and H2O2 plus propofol (H2O2 + propofol group), respectively...
February 7, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28167699/modulation-of-the-specific-glutathionylation-of-mitochondrial-proteins-in-the-yeast-saccharomyces-cerevisiae-under-basal-and-stress-conditions
#10
Rachel Gergondey, Camille Garcia, Christophe Marchand, Stephane Lemaire, Jean-Michel Camadro, Françoise Auchere
The potential biological consequences of oxidative stress and changes in glutathione levels include the oxidation of susceptible protein thiols and reversible covalent binding of glutathione to the -SH groups of proteins by S-glutathionylation. Mitochondria are central to the response to oxidative stress and redox signaling. It is therefore crucial to explore the adaptive response to changes in thiol-dependent redox status in these organelles.We optimized the purification protocol of glutathionylated proteins in the yeast S...
February 6, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28158949/methionine-sulfoxide-reductase-a-deficiency-exacerbates-cisplatin-induced-nephrotoxicity-via-increased-mitochondrial-damage-and-renal-cell-death
#11
Mi Ra Noh, Ki Young Kim, Sang Jun Han, Jee In Kim, Hwa-Young Kim, Kwon Moo Park
AIMS: Methionine sulfoxide reductase A (MsrA), which is abundantly localized in the mitochondria, reduces methionine-S-sulfoxide scavenging reactive oxygen species (ROS). Cisplatin, an anticancer drug, accumulates at high levels in the mitochondria of renal cells, causing mitochondrial impairment that ultimately leads to nephrotoxicity. Here, we investigated the role of MsrA in cisplatin-induced mitochondrial damage and kidney cell death using MsrA gene-deleted (MsrA-/-) mice. RESULTS: Cisplatin injection resulted in increases of ROS production, methionine oxidation, and oxidative damage in the kidneys...
February 3, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28148716/a-prodrug-of-two-approved-drugs-cisplatin-and-chlorambucil-for-chemo-war-against-cancer
#12
Rakesh K Pathak, Ru Wen, Nagesh Kolishetti, Shanta Dhar
Cancer cells maintain normal mitochondrial glutathione as one of the defense mechanisms to inhibit mitochondrial membrane polarization and hence apoptosis. A combinational therapeutic modality Platin-Cbl, a prodrug of Food and Drug Administration (FDA) approved chemotherapeutic agents, cisplatin and chlorambucil (Cbl), was synthesized and characterized to explore the potential of this compound to initiate chemo war on cancer cells using the active drugs, cisplatin and Cbl, when delivered to the cellular power house mitochondrion using a targeted nanoparticle (NP) designed to get associated with this organelle...
February 1, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28146406/humulus-japonicus-prevents-dopaminergic-neuron-death-in-6-hydroxydopamine-induced-models-of-parkinson-s-disease
#13
Young-Kyoung Ryu, Young Kang, Jun Go, Hye-Yeon Park, Jung-Ran Noh, Yong-Hoon Kim, Jung Hwan Hwang, Dong-Hee Choi, Sang-Seop Han, Won-Keun Oh, Chul-Ho Lee, Kyoung-Shim Kim
Humulus japonicus (HJ), popularly known as Japanese hops, is a traditional herbal medicine widely used for the treatment of pulmonary disease, skin disease, and hypertension in Korea. HJ exerts scavenging effects against reactive oxygen species (ROS), such as superoxide radical, hydroxyl radical, and hydrogen peroxide. Moreover, dysfunction and damage of mitochondria elicited by ROS are of critical importance in the pathogenesis of Parkinson's disease (PD). The present study aimed to examine neuroprotective potential of extracts of HJ using in vitro and in vivo 6-hydroxydopamine (6-OHDA) models...
February 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28141910/the-mechanism-of-valproic-acid-induced-fanconi-syndrome-involves-mitochondrial-dysfunction-and-oxidative-stress-in-rat-kidney
#14
Reza Heidari, Faezeh Jafari, Forouzan Khodaei, Babak Shirazi Yeganeh, Hossein Niknahad
AIM: Drug-induced kidney proximal tubular injury and renal failure (Fanconi syndrome; FS) is a clinical complication. Valproic acid (VPA) is among the FS-inducing drugs. The current investigation was designed to evaluate the role of mitochondrial dysfunction and oxidative stress in VPA-induced renal injury. METHODS: Animals received VPA (250 and 500 mg/kg, i.p., 15 consecutive days). Serum biomarkers of kidney injury and markers of oxidative stress were assessed...
January 31, 2017: Nephrology
https://www.readbyqxmd.com/read/28138507/data-on-hepg2-cells-changes-following-exposure-to-cadmium-sulphide-quantum-dots-cds-qds
#15
Laura Paesano, Alessio Perotti, Annamaria Buschini, Cecilia Carubbi, Marta Marmiroli, Elena Maestri, Salvatore Iannotta, Nelson Marmiroli
The data included in this paper are associated with the research article entitled "Markers for toxicity to HepG2 exposed to cadmium sulphide quantum dots; damage to mitochondria" (Paesano et al.) [1]. The article concerns the cytotoxic and genotoxic effects of CdS QDs in HepG2 cells and the mechanisms involved. In this dataset, changes in expression levels of candidate genes are reported, together with details concerning synthesis and properties of CdS QDs, additional information obtained through literature survey, measures of the mitochondrial membrane potential and the glutathione redox state...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28135329/hepatic-effects-of-pharmacological-doses-of-hydroxy-cobalamin-c-lactam-in-mice
#16
Patrizia Haegler, David Grünig, Benjamin Berger, Luigi Terracciano, Stephan Krähenbühl, Jamal Bouitbir
The vitamin B12 analog hydroxy-cobalamin[c-lactam] (HCCL) impairs hepatic mitochondrial protein synthesis and function of the electron transport chain in rats. We aimed to establish an in vivo model for mitochondrial dysfunction in mice, which could be used to investigate hepatotoxicity of mitochondrial toxicants. In a first step, we performed a dose-finding study in mice treated with HCCL 0.4 mg/kg and 4 mg/kg i.p. for two to four weeks. The plasma methylmalonate concentration was strongly increased at 4 mg/kg starting at three weeks of treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28129719/differences-in-reperfusion-induced-mitochondrial-oxidative-stress-and-cell-death-between-hippocampal-ca1-and-ca3-subfields-is-due-to-the-mitochondrial-thioredoxin-system
#17
Bocheng Yin, German Barrionuevo, Ines Batinic-Haberle, Mats Sandberg, Stephen Weber
AIMS: The susceptibility of CA1 over CA3 to damage from cerebral ischemia may be related to the differences in reactive oxygen species (ROS) production/removal between the two hippocampal subfields. We aimed to measure CA1/CA3 differences in net ROS production in real time in the first thirty minutes of reperfusion in pyramidal cells. We aimed to determine the underlying cause of the differential vulnerability of CA1 and CA3. RESULTS: Real-time determinations of mitochondrial H2O2 and, independently, glutathione (GSH) redox status from roGFP-based probes in individual pyramidal cells in organotypic hippocampal cultures during oxygen-glucose deprivation (OGD)-reperfusion (RP) demonstrate a significantly more oxidizing environment during reperfusion in CA1 than CA3 mitochondria...
January 27, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28129698/regulation-of-calcium-fluxes-by-gpx8-a-type-ii-transmembrane-peroxidase-enriched-at-the-mitochondria-associated-endoplasmic-reticulum-membrane
#18
Edgar Djaha Yoboue, Alessandro Rimessi, Tiziana Anelli, Paolo Pinton, Roberto Sitia
: Glutathione peroxidases (GPXs) are enzymes present in almost all organisms with the primary function of limiting peroxides accumulation. In mammals, two of the eight members (GPX7 and GPX8) reside in the endoplasmic reticulum (ER). A peculiar feature of GPX8 is the concomitant presence of a conserved N-terminal transmembrane domain (TMD) and a C-terminal KDEL-like motif for ER localization. AIMS: Investigating whether and how GPX8 impacts Ca2+ homeostasis and signaling...
January 27, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28123000/dual-role-of-epidermal-growth-factor-receptor-in-liver-injury-and-regeneration-after-acetaminophen-overdose-in-mice
#19
Bharat Bhushan, Hemantkumar Chavan, Prachi Borude, Yuchao Xie, Kuo Du, Mitchell R McGill, Margitta Lebofsky, Hartmut Jaeschke, Partha Krishnamurthy, Udayan Apte
Epidermal growth factor receptor (EGFR) plays a crucial role in hepatocyte proliferation. Its role in acetaminophen (APAP)-mediated hepatotoxicity and subsequent liver regeneration is completely unknown. Role of EGFR after APAP-overdose in mice was studied using pharmacological inhibition strategy. Rapid, sustained and dose-dependent activation of EGFR was noted after APAP-treatment in mice, which was triggered by glutathione depletion. EGFR-activation was also observed in primary human hepatocytes after APAP-treatment, preceding elevation of toxicity markers...
February 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28119815/synthesis-of-hydroxycinnamic-acid-derivatives-as-mitochondria-targeted-antioxidants-and-cytotoxic-agents
#20
Jiyu Li, Dian He, Baitao Wang, Ling Zhang, Kun Li, Qinjian Xie, Lifang Zheng
In order to develop agents with superior chemopreventive and chemotherapeutic properties against hepatocellular carcinomas, mitochondria-targeted hydroxycinnamic acids (MitoHCAs) were synthesized by conjugation with a triphenylphosphonium cation. These synthetic compounds were evaluated for their antioxidant activities in hepatic mitochondria, including against OH(∙-) and ROO(∙-) induced lipid peroxidation. H2O2 production was decreased significantly by increasing glutathione peroxidase and catalase activities...
January 2017: Acta Pharmaceutica Sinica. B
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