Irene Defrancesco, Silvia Zibellini, Emanuela Boveri, Marco Frigeni, Virginia Valeria Ferretti, Ettore Rizzo, Arturo Bonometti, Francesca Capuano, Chiara Candido, Sara Rattotti, Annamaria Tenore, Cristina Picone, Elena Flospergher, Caterina Zerbi, Fabio Bergamini, Nicole Fabbri, Caterina Cristinelli, Marzia Varettoni, Marco Paulli, Luca Arcaini
Non-chronic lymphocytic leukemia (non-CLL) clonal B-cell lymphocytosis (CBL) encompasses a heterogeneous group of hematologic disorders that are still poorly understood. To shed light on their biological aspects, we retrospectively analyzed a highly selected series of 28 patients, who had a clonal B-cell population in the peripheral blood and in the bone marrow, without evidence of lymphoma. Extended targeted-next generation sequencing revealed wide molecular heterogeneity with MYD88 (14%), PDE4DIP (14%), BIRC3 (11%), CCND3 (11%), NOTCH1 (11%) and TNFAIP3 (11%) as the most mutated genes...
August 1, 2020: Hematological Oncology