keyword
MENU ▼
Read by QxMD icon Read
search

splenic diffuse red pulp b cell lymphoma

keyword
https://www.readbyqxmd.com/read/29199492/development-of-b-cell-prolymphocytic-leukemia-in-a-patient-with-splenic-diffuse-red-pulp-small-b-cell-lymphoma
#1
Wen-Yan Cheng, Yong-Mei Zhu, Shu Cheng, Yun-Shuo Chen, Yang Shen
No abstract text is available yet for this article.
December 3, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29136691/-tumors-of-lymphoid-and-hematopoietic-tissue-of-spleen-a-clinicopathologic-analysis-of-53-cases
#2
D B Chen, D H Shen, H Zhang, Y Wang, Q J Song, S M Yang, X Z Fang
Objective: To study the clinicopathologic features, diagnosis and differential diagnosis of the tumors of lymphoidand hematopoietic tissue of the spleen(TLTS). Methods: Fifty-three cases of TLTS were selected from the pathologic files from Peking University People's Hospital from April 2002 to April 2017. According to WHO classification of tumors of hematopoietic and lymphoid tissues (2008) and its updated classification (2016), the cases were studied by microscopy, immunohistochemistry and in situ hybridization, combined with the bone marrow biopsy and clinical examination...
November 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29110361/hairy-cell-leukemia-2018-update-on-diagnosis-risk-stratification-and-treatment
#3
Xavier Troussard, Edouard Cornet
DISEASE OVERVIEW: Hairy cell leukemia (HCL) and HCL-like disorders, including HCL variant (HCL-V) and splenic diffuse red pulp lymphoma (SDRPL), are a very heterogeneous group of mature lymphoid B-cell disorders, characterized by the identification of hairy cells, a specific genetic profile, a different clinical course and the need for appropriate treatment. DIAGNOSIS: Diagnosis of HCL is based on morphological evidence of hairy cells, an HCL immunologic score of 3 or 4 based on the CD11C, CD103, CD123, and CD25 expression, the trephine biopsy which makes it possible to specify the degree of tumoral medullary infiltration and the presence of BRAF V600E somatic mutation...
December 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28751561/exome-sequencing-identifies-recurrent-bcor-alterations-and-the-absence-of-klf2-tnfaip3-and-myd88-mutations-in-splenic-diffuse-red-pulp-small-b-cell-lymphoma
#4
Laurent Jallades, Lucile Baseggio, Pierre Sujobert, Sarah Huet, Kaddour Chabane, Evelyne Callet-Bauchu, Aurélie Verney, Sandrine Hayette, Jean-Pierre Desvignes, David Salgado, Nicolas Levy, Christophe Béroud, Pascale Felman, Françoise Berger, Jean-Pierre Magaud, Laurent Genestier, Gilles Salles, Alexandra Traverse-Glehen
Splenic diffuse red pulp lymphoma is an indolent small B-cell lymphoma recognized as a provisional entity in the World Health Organization 2008 classification. Its precise relationship to other related splenic B-cell lymphomas with frequent leukemic involvement or other lymphoproliferative disorders remains undetermined. We performed whole-exome sequencing to explore the genetic landscape of ten cases of splenic diffuse red pulp lymphoma using paired tumor and normal samples. A selection of 109 somatic mutations was then evaluated in a cohort including 42 samples of splenic diffuse red pulp lymphoma and compared to those identified in 46 samples of splenic marginal zone lymphoma and eight samples of hairy-cell leukemia...
October 2017: Haematologica
https://www.readbyqxmd.com/read/28493517/clinicopathological-analysis-of-primary-splenic-diffuse-large-b-cell-lymphoma
#5
Joji Shimono, Hiroaki Miyoshi, Junichi Kiyasu, Kensaku Sato, Tomohiko Kamimura, Tetsuya Eto, Takuto Miyagishima, Koji Nagafuji, Takanori Teshima, Koichi Ohshima
Splenic infiltration is often seen in diffuse large B-cell lymphoma (DLBCL). However, primary splenic DLBCL is rare and studies on its clinicopathological features are limited. We assessed 66 cases of primary splenic DLBCL and 309 control DLBCL, not otherwise specified. Hepatitis C virus antibody prevalence, B symptoms, poor performance status and CD5 positivity differed significantly between the primary splenic DLBCL and control DLBCL groups. Primary splenic DLBCL cases were classified histopathologically into two groups [white pulp pattern (n = 46), red pulp pattern (n = 20)]...
September 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28069605/splenic-diffuse-red-pulp-small-b-cell-lymphoma-displays-increased-expression-of-cyclin-d3-and-recurrent-ccnd3-mutations
#6
LETTER
Soraya Curiel-Olmo, Rufino Mondéjar, Carmen Almaraz, Manuela Mollejo, Laura Cereceda, Roso Marès, Sophia Derdak, Yolanda Campos-Martín, Ana Batlle, Sonia González de Villambrosía, Marta Gut, Julie Blanc, Alexandra Traverse-Glehen, Aurelie Verney, Lucile Baseggio, Francisca I Camacho, Andrew Wotherspoon, Kostas Stamatopoulos, Aliki Xochelli, Theodora Papadaki, George Kanellis, Maurilio Ponzoni, Monica García-Cosío, Jose P Vaqué, Sergi Beltrán, Ivo Gut, Miguel Angel Piris, Nerea Martínez
No abstract text is available yet for this article.
February 23, 2017: Blood
https://www.readbyqxmd.com/read/27581334/splenic-diffuse-red-pulp-small-b-cell-lymphoma-associated-with-hepatitis-b-virus-a-report-of-two-cases
#7
Mariana Nassif Kerbauy, Carolina Melo Fernandes, Evandro Dantas Bezerra, Luis Alberto de Padua Covas Lage, Sheila Aparecida Coelho Siqueira, Juliana Pereira
CONTEXT: Splenic diffuse red-pulp small B-cell lymphoma is a rare disease, representing less than 1% of all non-Hodgkin lymphomas (NHL). This entity is characterized by involvement of bone marrow sinusoids and peripheral blood. The majority of cases are at an advanced stage when diagnosed. Its pathogenesis is still poorly understood. CASE REPORTS: We report on two patients with chronic non-replicating hepatitis B virus (HBV) who developed splenic diffuse red-pulp small B-cell lymphoma...
July 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27438406/splenic-diffuse-red-pulp-small-b-cell-lymphoma-associated-with-hepatitis-b-virus-a-report-of-two-cases
#8
Mariana Nassif Kerbauy, Carolina Melo Fernandes, Evandro Dantas Bezerra, Luis Alberto de Padua Covas Lage, Sheila Aparecida Coelho Siqueira, Juliana Pereira
CONTEXT: Splenic diffuse red-pulp small B-cell lymphoma is a rare disease, representing less than 1% of all non-Hodgkin lymphomas (NHL). This entity is characterized by involvement of bone marrow sinusoids and peripheral blood. The majority of cases are at an advanced stage when diagnosed. Its pathogenesis is still poorly understood. CASE REPORTS: We report on two patients with chronic non-replicating hepatitis B virus (HBV) who developed splenic diffuse red-pulp small B-cell lymphoma...
July 18, 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27358901/primary-splenic-red-pulp-diffuse-large-b-cell-lymphoma-with-anaplastic-features
#9
Binny Khandakar, Wei Wang, Shaoying Li
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/27347751/splenic-diffuse-red-pulp-lymphoma-has-a-distinct-pattern-of-somatic-mutations-amongst-b-cell-malignancies
#10
Alexandra Traverse-Glehen, Aurélie Verney, Sophie Gazzo, Laurent Jallades, Kaddour Chabane, Sandrine Hayette, Bertrand Coiffier, Evelyne Callet-Bauchu, Martine Ffrench, Pascale Felman, Françoise Berger, Lucile Baseggio, Gilles Salles
Splenic Diffuse Red Pulp Lymphoma (SDRPL) has been recently introduced as a provisional entity but differential diagnosis with other splenic lymphomas is needed to be clarified since the therapeutic approaches are distinct. Recently described recurrent mutations or CD180 expression appear useful for differential diagnosis. We completed our previous description in a larger cohort including 53 patients selected on the presence of characteristic villous cells in peripheral blood (PB) and a specific immunophenotype...
June 27, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27131623/a-single-center-experience-in-splenic-diffuse-red-pulp-lymphoma-diagnosis
#11
Hunan L Julhakyan, L S Al-Radi, T N Moiseeva, K I Danishyan, A M Kovrigina, S M Glebova, S A Lugovskaya, V N Dvirnik, A N Khvastunova, I A Yakutik, V G Savchenko
The World Health Organization 2008 classification highlighted a new nosology-splenic diffuse red pulp lymphoma (SDRPL) with clinical and laboratory features similar to both splenic marginal zone lymphoma and hairy cell leukemia (HCL) and variant form of HCL. Experience of hematologists on the diagnosis and differential diagnosis of SDRPL is extremely limited. The aim of our report was to characterize the clinical and immunomorphologic features of SDRPL on our own observations. During 2013-2014, in National Research Center for Hematology, 87 spleen specimens removed from various B-cell lymphomas were analyzed...
August 2016: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/26868143/cd27-positive-hairy-cell-leukemia-japanese-variant
#12
Rie Tabata, Chiharu Tabata, Hideaki Iwama, Ryoji Yasumizu, Masaru Kojima
We report a very rare case of a 45-year-old Japanese male patient with hairy cell leukemia-Japanese variant (HCL-JV) expressing CD27. The patient showed a high number of abnormal peripheral lymphocytes, thrombocytopenia, and severe splenomegaly but no lymphadenopathy. Histology of the resected spleen showed small-sized lymphoma cells diffusely infiltrating the red pulp without follicle formation. By immunohistochemistry, lymphoma cells were negative for CD3, CD5, CD8, CD10, CD34, cyclin-D1, and annexin A1 but positive for CD20 and BCL2...
March 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/26614898/bone-marrow-and-splenic-histology-in-hairy-cell-leukaemia
#13
REVIEW
Andrew Wotherspoon, Ayoma Attygalle, Larissa Sena Teixeira Mendes
Hairy cell leukaemia is a rare chronic neoplastic B-cell lymphoproliferation that characteristically involves blood, bone marrow and spleen with liver, lymph node and skin less commonly involved. Histologically, the cells have a characteristic appearance with pale/clear cytoplasm and round or reniform nuclei. In the spleen, the infiltrate involves the red pulp and is frequently associated with areas of haemorrhage (blood lakes). The cells stain for B-cell related antigens as well as with antibodies against tartrate-resistant acid phosphatase, DBA44 (CD72), CD11c, CD25, CD103, CD123, cyclin D1 and annexin A1...
December 2015: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/26426381/notch1-tp53-and-map2k1-mutations-in-splenic-diffuse-red-pulp-small-b-cell-lymphoma-are-associated-with-progressive-disease
#14
MULTICENTER STUDY
Daniel Martinez, Alba Navarro, Alejandra Martinez-Trillos, Ricardo Molina-Urra, Blanca Gonzalez-Farre, Itziar Salaverria, Ferran Nadeu, Anna Enjuanes, Guillem Clot, Dolors Costa, Ana Carrio, Neus Villamor, Dolors Colomer, Antonio Martinez, Susanne Bens, Reiner Siebert, Andrew Wotherspoon, Sílvia Beà, Estella Matutes, Elias Campo
Splenic diffuse red pulp small B-cell lymphoma (SDRPL) is considered an indolent neoplasm and its pathogenesis is not well known. We investigated the molecular characteristics of 19 SDRPL patients, 5 of them with progressive disease. IGHV genes were mutated in 9/13 (69%). Cytogenetic and molecular studies identified complex karyotypes in 2 cases, and IGH rearrangements in 3, with PAX5 and potentially TCL1 as partners in each one of them. Copy number arrays showed aberrations in 69% of the tumors, including recurrent losses of 10q23, 14q31-q32, and 17p13 in 3, and 9p21 in 2 cases...
February 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26154707/new-insights-in-the-management-of-patients-with-hairy-cell-leukemia
#15
REVIEW
Edouard Cornet, Gandhi Damaj, Xavier Troussard
PURPOSE OF REVIEW: Although hairy cell leukemia (HCL) was identified in 1958 by Bouroncle and colleagues, HCL remains in 2015 a mysterious disease. Accurate diagnosis of HCL relies on the recognition of hairy cells by morphology and flow cytometry in blood and/or bone marrow. However, there are cases difficult to diagnose, particularly in variants of HCL. Furthermore, some diseases such as splenic diffuse red pulp small B-cell lymphoma are very close to HCL and may be misdiagnosed. Major advances in the management of patients who have HCL have been made following the use of purine nucleoside analogs...
September 2015: Current Opinion in Oncology
https://www.readbyqxmd.com/read/25858127/-chronic-b-cell-lymphoproliferative-disorders-with-hairy-cells
#16
Xavier Troussard, Édouard Cornet
The standardized blood smear examination is the first step in the diagnosis of a B-cell chronic lymphoproliferative disorder and can guide further investigations. In the laboratory, the identification of hairy cells on blood smear is a matter of daily practice. Hairy cell proliferations represent heterogeneous entities and their respective diagnoses can be difficult. If hairy cell leukemia (HCL) and splenic marginal zone lymphoma (SMZL) represent separate entities, the variant form of HCL (HCLv) and splenic diffuse red pulp small B-cell lymphoma (SDRPL) remain provisional entities in the 2008 WHO classification...
July 2015: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/24903677/a-comprehensive-immunophenotypic-marker-analysis-of-hairy-cell-leukemia-in-paraffin-embedded-bone-marrow-trephine-biopsies-a-tissue-microarray-study
#17
Judit Tóth-Lipták, Klára Piukovics, Zita Borbényi, Judit Demeter, Enikő Bagdi, László Krenács
Hairy cell leukemia (HCL) is an uncommon B cell lymphoproliferation characterized by a unique immunophenotype. Due to low number of circulating neoplastic cells and 'dry tap' aspiration, the diagnosis is often based on BM trephine biopsy. We have performed a consecutive immunohistochemical analysis to evaluate diagnostic usefulness of various HCL markers (CD11c, CD25, CD68, CD103, CD123, CD200, annexin A1, cyclin D1, DBA.44, HBME-1, phospho-ERK1/2, TRAP, and T-bet) currently available against fixation resistant epitopes...
January 2015: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/24092261/monoclonal-antibody-hbme-1-reacts-with-a-minor-subset-of-b-cells-with-villous-surface-and-can-be-useful-in-the-diagnosis-of-hairy-cell-leukemia-and-other-indolent-lymphoproliferations-of-villous-b-lymphocytes
#18
László Krenács, Judit Tóth-Lipták, Judit Demeter, Klára Piukovics, Zita Borbényi, Péter Gogolák, Eszter Sári, Enikő Bagdi
The Hector Battifora mesothelial epitope-1 (HBME-1) monoclonal antibody has been generated against human mesothelioma cells and recognizes a biochemically unknown membrane epitope. We have accidentally found that the HBME-1 reacts with scattered lymphocytes showing villous surface in hyperplastic lymphoid tissue. To evaluate its reactivity pattern, we have performed a consecutive immunohistochemical study in nonneoplastic bone marrow and lymphoid samples (n = 40), as well as in malignant lymphoproliferations (n = 427), including hairy cell leukemia (HCL) (n = 72), HCL variant (HCL-v) (n = 13), splenic diffuse red pulp small B cell lymphoma (SDRPL) (n = 8), splenic B cell marginal zone lymphoma (SMZL) (n = 59), and splenic B cell lymphoma/leukemia, not further classifiable on bone marrow morphology (SBCL) (n = 37) cases...
December 2013: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/23638236/primary-hepatosplenic-cd5-positive-diffuse-large-b-cell-lymphoma-a-case-report-with-literature-review
#19
REVIEW
Xiaohui Zhang, Manhua Sun, Ling Zhang, Haipeng Shao
De novo CD5-positive diffuse large B-cell lymphoma (CD5(+) DLBCL) accounts for approximately 10% of DLBCL, and is usually associated with aggressive clinical course. We report a case of CD5(+) DLBCL with primary involvement of the spleen and liver, and no distinct mass lesions or lymphadenopathy. The patient had stage IV disease with bone marrow involvement by lymphoma. The lymphoma cells showed characteristic portal and intrasinusoidal pattern of infiltrate in the liver. The literature was reviewed and the clinicopathologic features of 7 similar reported cases were summarized...
2013: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/23610457/primary-hepatic-and-hepatosplenic-diffuse-large-b-cell-lymphomas-with-intrasinusoidal-and-interstitial-lymphomatous-infiltration
#20
Makoto Kashimura, Kayoko Murayama, Masaru Kojima
Primary hepatic and hepatosplenic diffuse large B-cell lymphomas (DLBCLs) are rare cancers and form nodules in most instances. However, very rare cases can diffusely infiltrate the whole liver without nodules. The general clinicopathological features of these lymphomas have not been reported to date. In our current study, we attempted to elucidate the features of these lesions through our direct observations and by reviewing the current literature. We describe the characteristics of 2 patients with hepatic and hepatosplenic DLBCL by autopsy...
October 2013: International Journal of Surgical Pathology
keyword
keyword
104852
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"