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splenic diffuse red pulp b cell lymphoma

Joji Shimono, Hiroaki Miyoshi, Junichi Kiyasu, Kensaku Sato, Tomohiko Kamimura, Tetsuya Eto, Takuto Miyagishima, Koji Nagafuji, Takanori Teshima, Koichi Ohshima
Splenic infiltration is often seen in diffuse large B-cell lymphoma (DLBCL). However, primary splenic DLBCL is rare and studies on its clinicopathological features are limited. We assessed 66 cases of primary splenic DLBCL and 309 control DLBCL, not otherwise specified. Hepatitis C virus antibody prevalence, B symptoms, poor performance status and CD5 positivity differed significantly between the primary splenic DLBCL and control DLBCL groups. Primary splenic DLBCL cases were classified histopathologically into two groups [white pulp pattern (n = 46), red pulp pattern (n = 20)]...
May 11, 2017: British Journal of Haematology
Soraya Curiel-Olmo, Rufino Mondéjar, Carmen Almaraz, Manuela Mollejo, Laura Cereceda, Roso Marès, Sophia Derdak, Yolanda Campos-Martín, Ana Batlle, Sonia González de Villambrosía, Marta Gut, Julie Blanc, Alexandra Traverse-Glehen, Aurelie Verney, Lucile Baseggio, Francisca I Camacho, Andrew Wotherspoon, Kostas Stamatopoulos, Aliki Xochelli, Theodora Papadaki, George Kanellis, Maurilio Ponzoni, Monica García-Cosío, Jose P Vaqué, Sergi Beltrán, Ivo Gut, Miguel Angel Piris, Nerea Martínez
No abstract text is available yet for this article.
February 23, 2017: Blood
Mariana Nassif Kerbauy, Carolina Melo Fernandes, Evandro Dantas Bezerra, Luis Alberto de Padua Covas Lage, Sheila Aparecida Coelho Siqueira, Juliana Pereira
CONTEXT: Splenic diffuse red-pulp small B-cell lymphoma is a rare disease, representing less than 1% of all non-Hodgkin lymphomas (NHL). This entity is characterized by involvement of bone marrow sinusoids and peripheral blood. The majority of cases are at an advanced stage when diagnosed. Its pathogenesis is still poorly understood. CASE REPORTS: We report on two patients with chronic non-replicating hepatitis B virus (HBV) who developed splenic diffuse red-pulp small B-cell lymphoma...
July 2016: São Paulo Medical Journal, Revista Paulista de Medicina
Mariana Nassif Kerbauy, Carolina Melo Fernandes, Evandro Dantas Bezerra, Luis Alberto de Padua Covas Lage, Sheila Aparecida Coelho Siqueira, Juliana Pereira
CONTEXT: Splenic diffuse red-pulp small B-cell lymphoma is a rare disease, representing less than 1% of all non-Hodgkin lymphomas (NHL). This entity is characterized by involvement of bone marrow sinusoids and peripheral blood. The majority of cases are at an advanced stage when diagnosed. Its pathogenesis is still poorly understood. CASE REPORTS: We report on two patients with chronic non-replicating hepatitis B virus (HBV) who developed splenic diffuse red-pulp small B-cell lymphoma...
July 18, 2016: São Paulo Medical Journal, Revista Paulista de Medicina
Binny Khandakar, Wei Wang, Shaoying Li
No abstract text is available yet for this article.
2016: Stem Cell Investigation
Alexandra Traverse-Glehen, Aurélie Verney, Sophie Gazzo, Laurent Jallades, Kaddour Chabane, Sandrine Hayette, Bertrand Coiffier, Evelyne Callet-Bauchu, Martine Ffrench, Pascale Felman, Françoise Berger, Lucile Baseggio, Gilles Salles
Splenic Diffuse Red Pulp Lymphoma (SDRPL) has been recently introduced as a provisional entity but differential diagnosis with other splenic lymphomas is needed to be clarified since the therapeutic approaches are distinct. Recently described recurrent mutations or CD180 expression appear useful for differential diagnosis. We completed our previous description in a larger cohort including 53 patients selected on the presence of characteristic villous cells in peripheral blood (PB) and a specific immunophenotype...
June 27, 2016: Leukemia & Lymphoma
Hunan L Julhakyan, L S Al-Radi, T N Moiseeva, K I Danishyan, A M Kovrigina, S M Glebova, S A Lugovskaya, V N Dvirnik, A N Khvastunova, I A Yakutik, V G Savchenko
The World Health Organization 2008 classification highlighted a new nosology-splenic diffuse red pulp lymphoma (SDRPL) with clinical and laboratory features similar to both splenic marginal zone lymphoma and hairy cell leukemia (HCL) and variant form of HCL. Experience of hematologists on the diagnosis and differential diagnosis of SDRPL is extremely limited. The aim of our report was to characterize the clinical and immunomorphologic features of SDRPL on our own observations. During 2013-2014, in National Research Center for Hematology, 87 spleen specimens removed from various B-cell lymphomas were analyzed...
August 2016: Clinical Lymphoma, Myeloma & Leukemia
Rie Tabata, Chiharu Tabata, Hideaki Iwama, Ryoji Yasumizu, Masaru Kojima
We report a very rare case of a 45-year-old Japanese male patient with hairy cell leukemia-Japanese variant (HCL-JV) expressing CD27. The patient showed a high number of abnormal peripheral lymphocytes, thrombocytopenia, and severe splenomegaly but no lymphadenopathy. Histology of the resected spleen showed small-sized lymphoma cells diffusely infiltrating the red pulp without follicle formation. By immunohistochemistry, lymphoma cells were negative for CD3, CD5, CD8, CD10, CD34, cyclin-D1, and annexin A1 but positive for CD20 and BCL2...
March 2016: Virchows Archiv: An International Journal of Pathology
Andrew Wotherspoon, Ayoma Attygalle, Larissa Sena Teixeira Mendes
Hairy cell leukaemia is a rare chronic neoplastic B-cell lymphoproliferation that characteristically involves blood, bone marrow and spleen with liver, lymph node and skin less commonly involved. Histologically, the cells have a characteristic appearance with pale/clear cytoplasm and round or reniform nuclei. In the spleen, the infiltrate involves the red pulp and is frequently associated with areas of haemorrhage (blood lakes). The cells stain for B-cell related antigens as well as with antibodies against tartrate-resistant acid phosphatase, DBA44 (CD72), CD11c, CD25, CD103, CD123, cyclin D1 and annexin A1...
December 2015: Best Practice & Research. Clinical Haematology
Daniel Martinez, Alba Navarro, Alejandra Martinez-Trillos, Ricardo Molina-Urra, Blanca Gonzalez-Farre, Itziar Salaverria, Ferran Nadeu, Anna Enjuanes, Guillem Clot, Dolors Costa, Ana Carrio, Neus Villamor, Dolors Colomer, Antonio Martinez, Susanne Bens, Reiner Siebert, Andrew Wotherspoon, Sílvia Beà, Estella Matutes, Elias Campo
Splenic diffuse red pulp small B-cell lymphoma (SDRPL) is considered an indolent neoplasm and its pathogenesis is not well known. We investigated the molecular characteristics of 19 SDRPL patients, 5 of them with progressive disease. IGHV genes were mutated in 9/13 (69%). Cytogenetic and molecular studies identified complex karyotypes in 2 cases, and IGH rearrangements in 3, with PAX5 and potentially TCL1 as partners in each one of them. Copy number arrays showed aberrations in 69% of the tumors, including recurrent losses of 10q23, 14q31-q32, and 17p13 in 3, and 9p21 in 2 cases...
February 2016: American Journal of Surgical Pathology
Edouard Cornet, Gandhi Damaj, Xavier Troussard
PURPOSE OF REVIEW: Although hairy cell leukemia (HCL) was identified in 1958 by Bouroncle and colleagues, HCL remains in 2015 a mysterious disease. Accurate diagnosis of HCL relies on the recognition of hairy cells by morphology and flow cytometry in blood and/or bone marrow. However, there are cases difficult to diagnose, particularly in variants of HCL. Furthermore, some diseases such as splenic diffuse red pulp small B-cell lymphoma are very close to HCL and may be misdiagnosed. Major advances in the management of patients who have HCL have been made following the use of purine nucleoside analogs...
September 2015: Current Opinion in Oncology
Xavier Troussard, Édouard Cornet
The standardized blood smear examination is the first step in the diagnosis of a B-cell chronic lymphoproliferative disorder and can guide further investigations. In the laboratory, the identification of hairy cells on blood smear is a matter of daily practice. Hairy cell proliferations represent heterogeneous entities and their respective diagnoses can be difficult. If hairy cell leukemia (HCL) and splenic marginal zone lymphoma (SMZL) represent separate entities, the variant form of HCL (HCLv) and splenic diffuse red pulp small B-cell lymphoma (SDRPL) remain provisional entities in the 2008 WHO classification...
July 2015: Annales de Biologie Clinique
Judit Tóth-Lipták, Klára Piukovics, Zita Borbényi, Judit Demeter, Enikő Bagdi, László Krenács
Hairy cell leukemia (HCL) is an uncommon B cell lymphoproliferation characterized by a unique immunophenotype. Due to low number of circulating neoplastic cells and 'dry tap' aspiration, the diagnosis is often based on BM trephine biopsy. We have performed a consecutive immunohistochemical analysis to evaluate diagnostic usefulness of various HCL markers (CD11c, CD25, CD68, CD103, CD123, CD200, annexin A1, cyclin D1, DBA.44, HBME-1, phospho-ERK1/2, TRAP, and T-bet) currently available against fixation resistant epitopes...
January 2015: Pathology Oncology Research: POR
László Krenács, Judit Tóth-Lipták, Judit Demeter, Klára Piukovics, Zita Borbényi, Péter Gogolák, Eszter Sári, Enikő Bagdi
The Hector Battifora mesothelial epitope-1 (HBME-1) monoclonal antibody has been generated against human mesothelioma cells and recognizes a biochemically unknown membrane epitope. We have accidentally found that the HBME-1 reacts with scattered lymphocytes showing villous surface in hyperplastic lymphoid tissue. To evaluate its reactivity pattern, we have performed a consecutive immunohistochemical study in nonneoplastic bone marrow and lymphoid samples (n = 40), as well as in malignant lymphoproliferations (n = 427), including hairy cell leukemia (HCL) (n = 72), HCL variant (HCL-v) (n = 13), splenic diffuse red pulp small B cell lymphoma (SDRPL) (n = 8), splenic B cell marginal zone lymphoma (SMZL) (n = 59), and splenic B cell lymphoma/leukemia, not further classifiable on bone marrow morphology (SBCL) (n = 37) cases...
December 2013: Virchows Archiv: An International Journal of Pathology
Xiaohui Zhang, Manhua Sun, Ling Zhang, Haipeng Shao
De novo CD5-positive diffuse large B-cell lymphoma (CD5(+) DLBCL) accounts for approximately 10% of DLBCL, and is usually associated with aggressive clinical course. We report a case of CD5(+) DLBCL with primary involvement of the spleen and liver, and no distinct mass lesions or lymphadenopathy. The patient had stage IV disease with bone marrow involvement by lymphoma. The lymphoma cells showed characteristic portal and intrasinusoidal pattern of infiltrate in the liver. The literature was reviewed and the clinicopathologic features of 7 similar reported cases were summarized...
2013: International Journal of Clinical and Experimental Pathology
Makoto Kashimura, Kayoko Murayama, Masaru Kojima
Primary hepatic and hepatosplenic diffuse large B-cell lymphomas (DLBCLs) are rare cancers and form nodules in most instances. However, very rare cases can diffusely infiltrate the whole liver without nodules. The general clinicopathological features of these lymphomas have not been reported to date. In our current study, we attempted to elucidate the features of these lesions through our direct observations and by reviewing the current literature. We describe the characteristics of 2 patients with hepatic and hepatosplenic DLBCL by autopsy...
October 2013: International Journal of Surgical Pathology
Maurilio Ponzoni, George Kanellis, Evi Pouliou, Panagiotis Baliakas, Lydia Scarfò, Andrés J M Ferreri, Claudio Doglioni, Vasilis Bikos, Antonis Dagklis, Achilles Anagnostopoulos, Paolo Ghia, Kostas Stamatopoulos, Theodora Papadaki
Primary splenic small B-cell lymphomas mostly comprise the distinct entity of splenic marginal-zone lymphoma (SMZL) and the provisional category of splenic lymphoma/leukemia unclassifiable, mainly represented by the hairy cell leukemia variant and splenic diffuse red pulp small B-cell lymphoma (SDRL). Until recently, histopathologic examination of splenectomy specimens was considered mandatory for the diagnosis of SMZL. However, nowadays, mainly because of advances in chemoimmunotherapy, splenectomy is performed much less frequently...
November 2012: American Journal of Surgical Pathology
Kei Shimizu-Kohno, Yoshizo Kimura, Junichi Kiyasu, Hiroaki Miyoshi, Maki Yoshida, Riko Ichikawa, Daisuke Niino, Koichi Ohshima
Primary splenic lymphoma is rare, but malignant lymphoma often produces a lesion in the spleen as part of systemic disease. The frequency of splenic malignant lymphoma in Japan is unknown. We classified 184 specimens of the spleen according to the World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition (2008). Of the 184 specimens, 115 were determined to be lymphoid neoplasm (62.5%). The most common subtype of lymphoid neoplasm was diffuse large B-cell lymphoma (DLBCL) (46 cases), followed by splenic marginal zone lymphoma (SMZL) (28 cases), follicular lymphoma (11 cases), splenic B-cell lymphoma, unclassifiable (SBL-U) (6 cases) and peripheral T-cell lymphoma, not otherwise specified (4 cases)...
September 2012: Pathology International
Alexandra Traverse-Glehen, Lucile Baseggio, Gilles Salles, Bertrand Coiffier, Pascale Felman, Françoise Berger
Among splenic lymphomas with circulating cells presenting cytoplasmic projections, a homogeneous clinico-pathological entity has been recently individualized as Splenic Diffuse Red Pulp Lymphomas (SDRPL) and introduced in the provisional "unclassifiable splenic lymphoma" category of the current updated WHO classification until more is known. SDRPL presents characteristic circulating basophilic villous lymphocytes and diffuse infiltration of the splenic red pulp, distinct from Splenic Marginal Zone Lymphoma (SMZL) and Hairy Cell Leukemia (HCL), but reminiscent of HCL-Variant (HCL-V)...
April 2012: Discovery Medicine
Daniela Hoehn, Roberto N Miranda, Rashmi Kanagal-Shamanna, Pei Lin, L Jeffrey Medeiros
We describe 4 patients aged 62 to 79 years with splenomegaly and bone marrow involvement by splenic B-cell lymphoma who developed more than 55% prolymphocytes in blood. The diagnosis of B-cell prolymphocytic leukemia was considered clinically based on a markedly elevated leukocyte (up to 131.5×10(9)/L) or prolymphocyte (up to 86%) count. Splenectomy was performed in all patients, and spleen weight ranged from 1500 to 2380 g. In 3 patients, the neoplasms were classified as splenic marginal zone lymphoma, and in 1 patient, the neoplasm was classified as splenic diffuse red pulp small B-cell lymphoma...
November 2012: Human Pathology
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