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https://www.readbyqxmd.com/read/29330520/association-of-homocysteine-with-aysmptomatic-intracranial-and-extracranial-arterial-stenosis-in-hypertension-patients
#1
Yan Wang, Jin Zhang, Yuesheng Qian, Xiaofeng Tang, Huawei Ling, Kemin Chen, Yan Li, Pingjin Gao, Dingliang Zhu
Elevated plasma homocysteine (Hcy) is suggested as an independent risk factor for stroke. We aimed to investigate the association of Hcy concentration with intracranial atherosclerosis (ICAS) and extracranial AS (ECAS) in hypertensive patients without stroke in Chinese population and to explore modified effect of methylenetetrahydrofolate reductase (MTHFR) C677T on their relationship. The stenosis of intracranial and extracranial arteries were evaluated in a total of 929 subjects through computerized tomographic angiography (CTA) from aortic arch to the skull base...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29326089/associations-between-markers-of-oxidative-stress-skeletal-muscle-mass-and-function-and-to-the-influence-of-resistance-exercise-training-in-older-adults
#2
Ciriaco Carru, Mariasole Da Boit, Panagiotis Paliogiannis, Angelo Zinellu, Salvatore Sotgia, Rachael Sibson, Judith R Meakin, Richard M Aspden, Arduino A Mangoni, Stuart R Gray
BACKGROUND: Oxidative stress (OS) negatively affects skeletal muscle homeostasis in experimental models of ageing. However, little is known about the associations between circulating OS markers and parameters of muscle mass and function, and their responses to exercise training, in humans. METHODS: Maximal voluntary contraction (MVC, primary outcome) and isokinetic torque of the knee extensors at 30° s-1 (MIT), muscle cross-sectional area (MCSA) and quality (MQ, secondary outcomes), and plasma concentrations of malondialdehyde (MDA, pro-OS), homocysteine (HCY, pro-OS), taurine (TAU, anti-OS), and protein sulphydryl groups (PSH, anti-OS) were measured in 27 healthy older males and 23 females at baseline and after an 18-week resistance exercise program, with or without a nutritional intervention (fish oil vs...
January 8, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29325799/elevated-circulating-homocysteine-and-high-sensitivity-c-reactive-protein-jointly-predicts-post-stroke-depression-among-chinese-patients-with-acute-ischemic-stroke
#3
Jieyun Yin, Chongke Zhong, Zhengbao Zhu, Xiaoqing Bu, Tan Xu, Libing Guo, Xuemei Wang, Jintao Zhang, Yong Cui, Dong Li, Jianhui Zhang, Zhong Ju, Chung-Shiuan Chen, Jing Chen, Yonghong Zhang, Jiang He
BACKGROUND: Homocysteine (HCY) and high sensitivity C reactive protein (hs-CRP) were suggested to be involved in post-stroke depression (PSD), which is a frequent mood disorder after stroke. However, the combined effect of HCY and hs-CRP on PSD remains unclear. METHODS: A total of 598 acute ischemic stroke patients from 7 of 26 centers participating in the China Antihypertensive Trial in Acute Ischemic Stroke with HCY or hs-CRP measurements were included in this analysis...
January 8, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29323380/aldehyde-functionalized-metal-organic-frameworks-for-selective-sensing-of-homocysteine-over-cys-gsh-and-other-natural-amino-acids
#4
Jian Wang, Yanhong Liu, Min Jiang, Yang Li, Lingling Xia, Pengyan Wu
A novel aldehyde-functionalized porous metal-organic framework (MOF) material has been constructed that can act as the first example of MOF-implicated sensors for discriminating Hcy from natural amino acids and even thiol-related peptides (GSH) with high sensitivity (LOD = 40 nM). The sensing mechanism is also discussed.
January 11, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29322314/cognitive-impairment-is-associated-with-elevated-serum-homocysteine-levels-among-older-adults
#5
Sunghee Kim, Bo Youl Choi, Jung Hyun Nam, Mi Kyung Kim, Dong Hoon Oh, Yoon Jung Yang
PURPOSE: The aim of this study was to examine the associations between the risk of cognitive impairment and the serum levels of folate, vitamin B12, and homocysteine (Hcy). METHODS: Subjects were persons aged 60-79 years who participated in the Yangpyeong Cohort study between 2011 and 2012. Cognitive impairment and normal subjects consisted of 100 pairs of old adults matched by age, sex, and education levels. Cognitive function was evaluated with the Korean version of the Mini-Mental State Examination for Dementia Screening (MMSE-DS)...
January 10, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29321517/genome-wide-association-study-of-homocysteine-in-african-americans-from-the-jackson-heart-study-the-multi-ethnic-study-of-atherosclerosis-and-the-coronary-artery-risk-in-young-adults-study
#6
Laura M Raffield, Jaclyn Ellis, Nels C Olson, Qing Duan, Jin Li, Peter Durda, Nathan Pankratz, Brendan J Keating, Christina L Wassel, Mary Cushman, James G Wilson, Myron D Gross, Russell P Tracy, Stephen S Rich, Alex P Reiner, Yun Li, Monte S Willis, Ethan M Lange, Leslie A Lange
Homocysteine (Hcy) is a heritable biomarker for CVD, peripheral artery disease, stroke, and dementia. Little is known about genetic associations with Hcy in individuals of African ancestry. We performed a genome-wide association study for Hcy in 4927 AAs from the Jackson Heart Study (JHS), the Multi-Ethnic Study of Atherosclerosis (MESA), and the Coronary Artery Risk in Young Adults (CARDIA) study. Analyses were stratified by sex and results were meta-analyzed within and across sex. In the sex-combined meta-analysis, we observed genome-wide significant evidence (p < 5...
January 10, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29319008/cardiovascular-risk-factors-in-noise-exposed-workers-in-china-small-area-study
#7
Xiaoyuan Wu, Daya Yang, Wendong Fan, Chunyue Fan, Guifu Wu
INTRODUCTION: The aim of the present study was to evaluate whether there are changes in cardiovascular risk factors among noise-exposed workers and to explore the possible mechanisms of a long-term noise exposure leading to cardiovascular disease and the sex differences of cardiovascular risk factors in this population. MATERIALS AND METHODS: Two hundred workers engaged in noise-related work, and a control group of 200 nonnoise-exposed workers hospitalized for occupational health examination were assigned into the study...
November 2017: Noise & Health
https://www.readbyqxmd.com/read/29318097/flavin-based-light-driven-fluorescent-probe-for-the-detection-of-antioxidant-amino-acids
#8
Kyeong-Im Hong, Seong Min Lee, Woo-Dong Jang
We have synthesized a flavin-N(5)-oxide derivative with a p-toluenesulfonyl (Ts-OF) group as a "turn-on" fluorescent probe for the detection of several antioxidant amino acids and biothiols. Oxidized flavin was synthesized by using dithiothreitol as the reducing agent. Ts-OF showed a light-driven fluorescence enhancement in the presence of several amino acids and biothiols such as histidine (His), methionine (Met), cysteine (Cys), glutathione (GSH), and homocysteine (Hcy). The 1H NMR study indicated the reductive elimination of the p-toluenesulfonyl group from Ts-OF in the presence of antioxidants and photo-irradiation...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29288439/hyperhomocysteinemia-in-acute-iatrogenic-hypothyroidism-the-relevance-of-thyroid-autoimmunity
#9
F Cicone, M G Santaguida, G My, G Mancuso, A Papa, R Persechino, C Virili, N Brusca, A Tofani, F Scopinaro, M Centanni
PURPOSE: Hyperhomocysteinemia is a known cardiovascular risk factor and a key player in the inflammatory activation of autoimmune diseases. Hashimoto's thyroiditis (HT) is the leading cause of hypothyroidism which, in itself, has been associated with a significant raise of homocysteine (Hcy) levels and increased cardiovascular risk. Our aim was to assess the impact of HT on Hcy levels in patients with acute hypothyroidism. METHODS: We prospectively enrolled 121 patients (mean age: 46 years, F/M = 102/19) with acute post-surgical hypothyroidism...
December 29, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29262410/association-between-plasma-homocysteine-and-microalbuminuria-in-untreated-patients-with-essential-hypertension-a-case-control-study
#10
Ze-Min Kuang, Ying Wang, Shu-Jun Feng, Long Jiang, Wen-Li Cheng
BACKGROUND/AIMS: Kidney function is critical for homocysteine (Hcy) clearance, and plasma Hcy levels are frequently increased in patients with renal failure. Microalbuminuria (MAU) is an important marker of early renal damage caused by hypertension. At present, there is insufficient evidence on the relationship between Hcy and microalbuminuria. METHODS: This is a 1: 2 matched, hospital-based case-control study. At initial visit, out of 1535 outpatients with no prior history of medication, 450 qualified subjects were selected based on inclusion and exclusion criteria...
December 15, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29262409/early-markers-of-cardiovascular-risk-in-autosomal-dominant-polycystic-kidney-disease
#11
Silvia Lai, Daniela Mastroluca, Silvia Matino, Valeria Panebianco, Antonio Vitarelli, Lidia Capotosto, Irene Turinese, Paolo Marinelli, Marco Rossetti, Alessandro Galani, Pia Baiocchi, Anna R D'Angelo, Paolo Palange
BACKGROUND/AIMS: Cardiovascular disease is the most frequent cause of morbidity and mortality in autosomal dominant polycystic kidney disease (ADPKD) patients, often before the onset of renal failure, and the pathogenetic mechanism is not yet well elucidated. The aim of the study was to identify early and noninvasive markers of cardiovascular risk in young ADPKD patients, in the early stages of disease. METHODS: A total of 26 patients with ADPKD and 24 control group, matched for age and sex, were enrolled, and we have assessed inflammatory indexes, mineral metabolism, metabolic state and markers of atherosclerosis and endothelial dysfunction (carotid intima media thickness (IMT), ankle brachial index (ABI), flow mediated dilation (FMD), renal resistive index (RRI), left ventricular mass index (LVMI)) and cardiopulmonary exercise testing (CPET), maximal O2 uptake (V'O2max), and O2 uptake at lactic acid threshold (V'O2@LT)...
December 15, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29247598/ligustrazine-suppresses-neuron-apoptosis-via-the-bax-bcl-2-and-caspase-3-pathway-in-pc12-cells-and-in-rats-with-vascular-dementia
#12
Tengfei Zhao, Yingxue Fu, Hao Sun, Xiaoquan Liu
The aim of this study was to examine the comprehensive neuroprotective mechanism of ligustrazine, which is extracted from Ligusticum Chuanxiong Hort., against vascular dementia (VD) in rats and apoptosis in oxygen and glucose deprivation (OGD) PC12 cells. Rats were subjected to bilateral common carotid artery occlusion (BCCAO) surgery and administered ligustrazine intragastrically for 6 weeks. At the end of the experiments, the hippocampal biomarkers brain-derived neurotrophic factor (BDNF), monocyte chemotactic protein 1 (MCP-1), and homocysteine (Hcy) were examined...
December 16, 2017: IUBMB Life
https://www.readbyqxmd.com/read/29245302/mthfr-c677t-gene-polymorphism-and-the-severity-of-coronary-lesions-in-acute-coronary-syndrome
#13
Miao-Nan Li, Hong-Ju Wang, Ning-Ru Zhang, Ling Xuan, Xiao-Jun Shi, Tong Zhou, Bin Chen, Jun Zhang, Hui Li
The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, circulating levels of homocysteine (Hcy), and the severity of coronary lesion in patients with acute coronary syndrome (ACS) remains unknown.Consecutive ACS patients were included. MTHFR C677T polymorphisms were determined via amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Gensini scores were used to evaluate the severity of coronary lesions.Three hundred ten ACS patients were included, and grouped according to the MTHFR C677T polymorphism variant: CC (n = 78, 25...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29227169/descriptive-study-of-the-relationship-between-the-subclinical-carotid-disease-and-biomarkers-carotid-femoral-pulse-wave-velocity-in-patients-with-hypertension
#14
XiaoXiao Zhao, Liujin Bo, Hongwei Zhao, Lihong Li, Yingyan Zhou, Hongyu Wang
BACKGROUND: Carotid intima-media thickness (cIMT) is a significant early prediction signal for preclinical atherosclerosis. Plasma homocysteine (Hcy) level is an independent risk factor for cardiovascular diseases. Pulse wave velocity (PWV), an index of arterial stiffness (AS), has showed its value in the evaluation of AS in vascular-related diseases. The data regarding the relationships between cIMT and other indices of vascular damage are limited and partly controversial. We aim to investigate the relationships between cIMT and other indices of vascular damage such as Hcy and carotid femoral PWV (CF-PWV)...
December 11, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29210571/molecular-engineering-of-%C3%AE-substituted-acrylate-ester-template-for-efficient-fluorescence-probe-of-hydrogen-polysulfides
#15
JingRu Guo, Sheng Yang, Chongchong Guo, Qinghai Zeng, Zhihe Qing, Zhong Cao, Jishan Li, Ronghua Yang
In this article, hydrogen polysulfide (H2Sn)-mediated Michael addition/cyclization cascade reactions toward acrylate ester analogues had been exploited and utilized to construct novel and robust H2Sn-specific fluorescence probe for the first time. Through rational molecular engineering of the α-substituted acrylate ester template, the optimal candidate probe FP-CF3 containing trifluoromethyl-substituted acrylate ester group as recognition unit and 3-benzothiazol-7-hydroxycoumarin dye BHC as signal reporter can highly selectively detect H2Sn over other reactive sulfur species, especially biothiols including cysteine (Cys), homocysteine (Hcy)/glutathione (GSH), with a rapid and significant turn-on fluorescence response (less than 60 secondsfor response time and over 44-fold for signal-to-background ratio)...
December 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29208848/assessment-of-homocysteine-as-a-diagnostic-and-early-prognostic-biomarker-for-patients-with-acute-lacunar-infarction
#16
Huimin Fan, Shuna Yang, Yue Li, Jiangmei Yin, Wei Qin, Lei Yang, Junliang Yuan, Wenli Hu
BACKGROUND: Although increasing evidence has demonstrated that elevated homocysteine (Hcy) levels may be an important contributor for the development of cerebral infarction, rare studies focused on its diagnostic and early prognostic roles in acute lacunar infarction. METHODS: A total of 197 patients with acute lacunar infarction and 192 to form the control group were prospectively recruited between January 2013 and February 2017. Early neurological deterioration was defined as an increase of ≥2 points in National Institutes of Health Stroke Scale or the decrease in Barthel index (BI) score at discharge...
November 29, 2017: European Neurology
https://www.readbyqxmd.com/read/29207911/soybean-amplifies-the-hypohomocysteinemic-effect-of-betaine-and-improves-its-hypercholesterolemic-effect
#17
Ryoko Shimada, Kiyoshi Ebihara
We examined whether soybean (SB) and soy protein isolate (SPI) can prevent the betaine-induced elevation of plasma cholesterol as well as maintain the betaine-induced reduction of plasma Hcy concentration. Rats were fed casein-, SB-, or SPI-based diet with or without betaine; SPI-based diet with betaine containing soybean fiber (SF) or soy lecithin (SL) or the combination of SF and SL. Plasma Hcy concentration was decreased by feeding betaine to rats fed the casein-, SB-, and SPI-based diets. Betaine-induced elevation of plasma cholesterol was decreased by feeding the SB-based diet compared with the casein-based diet, but was not decreased by feeding the SPI-based diet...
December 6, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29203427/the-association-between-plasma-homocysteine-and-ambulatory-blood-pressure-variability-in-patients-with-untreated-hypertension
#18
Suhua Li, Jieming Zhu, Lin Wu, Long Peng, Yanting Luo, Yunyue Zhao, Ruimin Dong, Lin Chen, Xixiang Tang, Jinlai Liu
BACKGROUND: Both homocysteine (Hcy) and blood pressure variability (BPV) are independent predictors of stroke, however, their relationship is rarely evaluated before. This study aimed to investigate the association Hcy and ambulatory BPV in subjects with untreated primary hypertension. METHODS: A total of 252 eligible patients were recruited. Plasma Hcy was measured and 24-h ambulatory blood pressure monitoring was performed for each subject. The systolic and diastolic BPV values were calculated as the SD of individual blood pressure values during 24h, daytime and nighttime, and then stratified by the tertiles of Hcy concentration (T1 to T3)...
December 2, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29201182/the-efficacy-of-gastrodin-in-combination-with-folate-and-vitamin-b12-on-patients-with-epilepsy-after-stroke-and-its-effect-on-hmgb-1-il-2-and-il-6-serum-levels
#19
Hao Zhou, Nuan Wang, Lei Xu, Hongli Huang, Chunyu Yu
This study evaluated the efficacy of gastrodin in combination with folate (FOL) and vitamin-B12 (V-B12) on patients with epilepsy after stroke (EAS) and its effect on high-mobility group protein B1 (HMGB-1), interleukin-1 (IL-1), and IL-6 serum levels. The clinical data of 92 EAS patients admitted for treatment between April, 2014 and March, 2016 were collected. These patients were randomly divided into control and observation groups (n=46 each) using computer software. Patients in the control group were administered only regular antiepileptic drugs, whereas observation group patients also received a combination of gastrodin, FOL and V-B12...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29192953/relationship-between-serum-homocysteine-levels-and-structural-functional-carotid-arterial-abnormalities-in-inactive-beh%C3%A3-et-s-disease
#20
Ramazan Ozdemir, Julide Yagmur, Nusret Acikgoz, Mehmet Cansel, Yelda Karincaoglu, Necip Ermis, Hasan Pekdemir, A Kadir Arslan
BACKGROUND: Behçet's disease (BD) is a chronic autoimmune disorder with symptoms manifesting from an underlying vasculitis. Since the disease activity is correlated with the characteristic vascular endothelial dysfunction, BD places individuals at increased risk of cardiovascular diseases, such as atherosclerosis. Hyperhomocysteinemia is an independent risk factor for arteriosclerotic vascular diseases. This study was designed to investigate how plasma homocysteine (Hcy) effects the structural and functional properties of the carotid artery in humans...
December 1, 2017: Kardiologia Polska
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