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https://www.readbyqxmd.com/read/28524030/-preventive-effect-of-vitamin-b-supplementation-on-recurrent-stroke-a-meta-analysis
#1
Guining Dai, Hongzhen Du, Hongmin Wang, Yujia Wei, Ying Xie, Zengning Li
OBJECTIVE: To evaluate whether Vitamin B supplementation could prevent ischemic stroke recurrence. METHODS: Randomized controlled trials (RCTs) observing Vitamin B supplementation in patients with stroke was performed in databases including ScienceDirect, PubMed/Medline, China National Knowledge Infrastructure, Chinese Biomedical Data-Base, Wanfang Database, and VIP Chinese Science and Technology Journal Database to find related studies in English or Chinese published before August 2016...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28515764/the-effect-of-epicatechin-on-oxidative-stress-and-mitochondrial-damage-induced-by-homocycteine-using-isolated-rat-hippocampus-mitochondria
#2
Fatemeh Shaki, Yaghoub Shayeste, Mohammad Karami, Esmaeil Akbari, Mahdi Rezaei, Ramin Ataee
Oxidative stress and mitochondrial dysfunction are the main suggested mechanisms for neurodegenerative diseases. In this study, we have evaluated the effects of epicatechin (EC) on mitochondrial damage induced by homocycteine (Hcy) using isolated rat hippocampus mitochondria in vivo. EC (50 mg/kg) was gavaged daily for a period of 10 days, starting 5 days prior to Hcy (0.5 μmol/μL) intra hippocampus injection in rats. Mitochondria were isolated from brain by different centrifuge techniques. Mitochondrial function was assayed by MTT test...
April 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28513237/t-cell-subsets-are-associated-with-serum-homocysteine-concentration-in-patients-with-essential-hypertension
#3
Huifeng Xu, Huan Zheng, Junling Huang, Yi Shen, Ming Luo
OBJECTIVE: To explore the association between serum homocysteine (Hcy) concentration and T-cell subsets from patients with essential hypertension. PATIENTS AND METHODS: A total of 218 essential hypertension patients were recruited, of which 170 were H-type essential hypertensive and 48 were non-H-type essential hypertensive. H-type essential hypertensive patients were divided into three groups by concentration of serum Hcy. The peripheral blood T-cell subsets (CD3(+)%, CD4(+)%, CD8(+) T%, CD4(+)/CD8(+)) and clinical features including age, sex, serum creatinine, uric acid, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were recorded and analyzed with T-cell subsets which were counted by fluorescence activated cytometry...
May 17, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28492674/a-phenazine-barbituric-acid-based-colorimetric-and-ratiometric-near-infrared-fluorescent-probe-for-sensitively-differentiating-biothiols-and-its-application-in-tio2-sensor-devices
#4
Xiao Zhang, Yongchao Yan, Yandi Hang, Jian Wang, Jianli Hua, He Tian
A new colorimetric and ratiometric near-infrared fluorescent probe based on phenazine-barbituric acid was developed to ultrasensitively detect biothiols. The favorable ratiometric changes helped the imaging and differentiation of Cys in living cells. Besides, the probe was successfully employed to construct TiO2 sensor devices, which could quantify Hcy concentration in serum.
May 11, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28489814/diagnostic-values-of-serum-levels-of-homocysteine-and-uric-acid-for-predicting-vascular-mild-cognitive-impairment-in-patients-with-cerebral-small-vessel-disease
#5
Ting Wang, Zhong-Wu Sun, Liang-Qing Shao, Xiao-Bin Xu, Yang Liu, Mao Qin, Xiang Weng, Yong-Xiang Zhang
BACKGROUND This study aimed to investigate the diagnostic values of serum levels of Hcy and UA for predicting vascular mild cognitive impairment (VMCI) in patients with cerebral small vessel disease (SVD). MATERIAL AND METHODS We selected 172 cerebral SVD patients and divided them into a VMCI group and a non-VMCI group. Eighty-six healthy individuals without nervous system diseases were selected as the control group. Enzymatic cycling method was performed to detect serum Hcy and UA levels. Serum levels of folic acid (FOA) and vitamin B12 (VitB12) were detected by chemiluminescence immunoassay...
May 10, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28487633/cochlear-homocysteine-metabolism-at-the-crossroad-of-nutrition-and-sensorineural-hearing-loss
#6
REVIEW
Teresa Partearroyo, Néstor Vallecillo, María A Pajares, Gregorio Varela-Moreiras, Isabel Varela-Nieto
Hearing loss (HL) is one of the most common causes of disability, affecting 360 million people according to the World Health Organization (WHO). HL is most frequently of sensorineural origin, being caused by the irreversible loss of hair cells and/or spiral ganglion neurons. The etiology of sensorineural HL (SNHL) is multifactorial, with genetic and environmental factors such as noise, ototoxic substances and aging playing a role. The nutritional status is central in aging disability, but the interplay between nutrition and SNHL has only recently gained attention...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28486919/metabolic-imbalance-of-homocysteine-and-hydrogen-sulfide-in-kidney-disease
#7
O Karmin, Yaw L Siow
Homocysteine (Hcy) and hydrogen sulfide (H2S) are important molecules produced during the metabolism of sulfur-containing amino acids. Hcy metabolism is central to the supply of methyl groups that are essential for biological function. Hcy can be either regenerated to methionine or metabolized to cysteine, a precursor for glutathione synthesis. Cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) play a crucial role in metabolizing Hcy to cysteine through the transsulfuration pathway. These two enzymes are also responsible for H2S generation through desulfuration reactions...
May 9, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28485501/mir-34a-targets-hdac1-regulated-h3k9-acetylation-on-lipid-accumulation-induced-by-homocysteine-in-foam-cells
#8
Qingguo Zhao, Shuqiang Li, Nan Li, Xiaoling Yang, Shengchao Ma, Anning Yang, Hui Zhang, Songhao Yang, Caiyan Mao, Lingbo Xu, Tingting Gao, Xiaoming Yang, Huiping Zhang, Yideng Jiang
Hyperhomocysteinemia (HHcy) promotes atherogenesis by modification of histone acetylation patterns and regulation of miRNA expression while the underlying molecular mechanisms are not well known. In this study, we investigated the effects of homocysteine (Hcy) on the expression of histone deacetylase 1 (HDAC1) and tested our hypothesis that Hcy-induced atherosclerosis is mediated by increased HDAC1 expression, which is regulated by miR-34a. The expression of HDAC1 increased and acetylation of histone H3 at lysine 9 (H3K9ac) decreased in the aorta of ApoE(-/-) mice fed with high methionine diet, whereas miR-34a expression was inhibited...
May 9, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28465603/joint-effect-of-maternal-plasma-homocysteine-and-prepregnancy-obesity-on-child-blood-pressure-a-prospective-birth-cohort-study
#9
H Wang, B P Xu, R B Xu, S O Walker, G Wang
BACKGROUND/OBJECTIVES: Elevated homocysteine (Hcy) is a known cardiovascular risk factor. However, its role in intergenerational cardiometabolic risk is unknown. We hypothesized that maternal elevated Hcy can act alone or in combination with maternal prepregnancy obesity to increase child systolic blood pressure (SBP). METHODS: This study included 1279 mother-child pairs who were enrolled at birth and followed prospectively up to age 9 years from 2003-2014 at the Boston Medical Center...
May 3, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28463405/studying-the-association-between-methylene-tetrahdrofolate-reductase-mthfr-677-gene-polymorphism-cardiovascular-risk-and-lichen-planus
#10
Laila Rashed, Rania Abdel Hay, Marwa AlKaffas, Shereen Ali, Dina Kadry, Sara Abdallah
BACKGROUND: There is a reported relation between hyperhomocysteinemia and lichen planus (LP). An increase in homocysteine (Hcy) and the risk of cardiovascular disease (CVD) in patients with methylenetetrahydrofolate reductase (MTHFR) mutation has been described OBJECTIVE: To detect MTHFR (C677T) gene polymorphism, and to find its association with CVD risk, Hcy and folic acid levels in patients with LP METHODS: This hospital-based case-control study included 110 patients with LP; 70 with cutaneous LP (CLP) and 40 with oral LP (OLP)...
April 30, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28460586/supplementation-with-6s-5-methyltetrahydrofolate-or-folic-acid-equally-reduces-serum-homocysteine-concentrations-in-older-adults
#11
Ewa Sicińska, Anna Brzozowska, Wojciech Roszkowski, Paul M Finglas
Folic acid (FA) supplementation reduces the elevated serum homocysteine (Hcy) concentrations. [6 S]-5-methyltetrahydrofolate ([6 S]-5-MTHF) is an alternative to FA due to possible advantages, that is, no masking cobalamin deficiency. The study aim was to evaluate the effectiveness of [6 S]-5-MTHF in relations to FA supplementation in reducing the serum Hcy. Healthy volunteers, aged 50-65, had normal serum folate and did not use supplements with B-vitamins for 6 months. Forty subjects were divided into two groups: receiving 400 μg/d FA or the equimolar amount of [6 S]-5-MTHF...
May 2, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28456936/combination-of-high-sensitivity-c-reactive-protein-and-homocysteine-predicts-the-post-stroke-depression-in-patients-with-ischemic-stroke
#12
Li-Shan Cheng, Wen-Jun Tu, Yuan Shen, Li-Jun Zhang, Kangxiang Ji
In this study, we examined the changes in high-sensitivity C-reactive protein (Hs-CRP) and homocysteine (HCY) levels, two of the risk factors, during the acute period of ischemic stroke (IS) and evaluated the relationship between these two factors and long-term post-stroke depression (PSD). In this study, 259 patients with IS had finished the follow-up and were included. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for depression at 1 year after stroke. The influence of Hs-CRP/CHY levels on PSD was performed by binary logistic regression analysis and receiver operating characteristic curves (ROC)...
April 29, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28454072/fluorescent-coumarin-based-probe-for-cysteine-and-homocysteine-with-live-cell-application
#13
Ling-Fang Wei, Natesan Thirumalaivasan, Yu-Cheng Liao, Shu-Pao Wu
Cysteine (Cys) and homocysteine (Hcy) are two of important biological thiols and function as important roles in several biological processes. The development of Cys and Hcy probes will help to explore the functions of biothiols in biological systems. In this work, a new coumarin-based probe AC, containing an acryloyl moiety, was developed for Cys and Hcy detection in cells. Cys and Hcy undergo a nucleophilic addition and subsequent cyclization reaction to remove to the acryloyl group and yield a fluorescent product, 7-hydroxylcomuarin...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28443883/an-aza-bodipy-based-near-infrared-fluorescent-probe-for-sensitive-discrimination-of-cysteine-homocysteine-and-glutathione-in-living-cells
#14
Hui-Jing Xiang, Huijun Phoebe Tham, Minh Duc Nguyen, Soo Zeng Fiona Phua, Wei Qi Lim, Jin-Gang Liu, Yanli Zhao
Discriminative detection of glutathione (GSH) from cysteine/homocysteine (Cys/Hcy) is achieved through two emission channel analysis using a stable, highly sensitive, and selective near-infrared fluorescent probe that bears 7-nitrobenzo-2-oxa-1,3-diazole and aza-BODIPY units. The probe was successfully applied for simultaneous determination of GSH and Cys/Hcy in living cells.
May 4, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28430117/fluvastatin-therapy-could-not-decrease-progression-of-paroxysmal-atrial-fibrillation-in-non-valvular-disease-patients
#15
Qiang Tan, Shuangyue Zhang, Xiaoyi Zou, Jun Zhao, Jia Hao, Qian Sun
OBJECTIVE: This study aimed to evaluate whether fluvastatin therapy could decrease the probability of atrial fibrillation (AF) progression from paroxysmal AF to permanent AF and decrease the recurrence frequency of AF. METHODS: Analyses were performed using two-tailed Student's t test or Mann-Whitney U tests. Categorical variables were compared with the χ2 statistics or Fisher's exact test. Patients with paroxysmal AF were randomized case-control, prospective into either the fluvastatin group (n=61) or control group (n=57)...
April 10, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28423345/homocysteine-induced-peripheral-microcirculation-dysfunction-in-zebrafish-and-its-attenuation-by-l-arginine
#16
Sang Joon Lee, Sung Ho Park, Jinhyuk Fred Chung, Woorak Choi, Hyung Kyu Huh
Elevated blood homocysteine (Hcy) level is frequently observed in aged individuals and those with age-related vascular diseases. However, its effect on peripheral microcirculation is still not fully understood. Using in vivo zebrafish model, the degree of Hcy-induced peripheral microcirculation dysfunction is assessed in this study with a proposed dimensionless velocity parameter V¯CV/V¯PCV, where V¯CV and V¯PCV represent the peripheral microcirculation perfusion and the systemic perfusion levels, respectively...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421567/early-biomarker-response-and-patient-preferences-to-oral-and-intramuscular-vitamin-b12-substitution-in-primary-care-a-randomised-parallel-group-trial
#17
Corina Metaxas, Deborah Mathis, Cyrill Jeger, Kurt Eduard Hersberger, Isabelle Arnet, Philipp Walter
BACKGROUND: Vitamin B12 (VB12) deficiency can be treated with oral high-dose substitution or intramuscular (i.m.) injection of VB12. Whenever alternative routes of administration exist, patient preferences should be considered when choosing the treatment. We aimed to assess outpatient preferences towards oral or IM VB12 substitution and confirm noninferiority of early biomarker response with oral treatment, in a typical primary care population. METHODS: Prospective randomised nonblinded parallel-group trial...
April 19, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28421540/maternal-folic-acid-supplementation-during-pregnancy-improves-neurobehavioral-development-in-rat-offspring
#18
Xinyan Wang, Wen Li, Shou Li, Jing Yan, John X Wilson, Guowei Huang
Maternal folate status during pregnancy may influence central nervous system (CNS) development in offspring. However, the recommended intakes of folic acid for women of childbearing age differ among countries and there is still no consensus about whether folic acid should be supplemented continuously throughout pregnancy. We hypothesized that folic acid supplementation may be more beneficial for offspring's neurobehavioral development if prolonged throughout pregnancy instead of being limited to the periconceptional period...
April 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28419824/effect-of-risperidone-on-serum-homocysteine-levels-in-first-episode-drug-na%C3%A3-ve-patients-with-schizophrenia
#19
Ning Fan, Yunlong Tan, Fude Yang, Li Tian, Song Chen, Jia Li, Zhiren Wang, Xiangyang Zhang
Some studies have shown that homocysteine (Hcy) levels are increased in patients with schizophrenia, and may be involved in its pathophysiology. The purpose of this study was to investigate the effect of the atypical antipsychotic drug risperidone on serum Hcy levels and to explore the relationship between the changes in Hcy levels and the therapeutic outcome, which, to our best knowledge have not been investigated. Fifty-six first-episode and drug-naïve inpatients with schizophrenia were assigned to a 12-week treatment regime with risperidone...
April 15, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28409162/synergistic-effect-of-the-mthfr-c677t-and-ephx2-g860a-polymorphism-on-the-increased-risk-of-ischemic-stroke-in-chinese-type-2-diabetic-patients
#20
Liang Ma, Yongwei Jiang, Xiaomu Kong, Meihua Yan, Tingting Zhao, Hailing Zhao, Qian Liu, Haojun Zhang, Yongtong Cao, Ping Li
The aim of this study was to investigate the relationship between the combined effect of MTHFR C677T (rs1801133) and EPHX2 G860A (rs751141) polymorphism and ischemic stroke in Chinese T2DM patients. This case-control study included a total of 626 Chinese T2DM patients (236 T2DM patients with ischemic stroke and 390 T2DM patients without ischemic stroke). The rs1801133 and rs751141 were genotyped using real-time polymerase chain reaction. Statistical analysis was performed with SPSS 17.0. Results showed that the combined effect of MTHFR TT and EPHX2 GG or GA + AA genotype has a higher risk of ischemic stroke compared with the control group (combined effect of MTHFR CC and EPHX2 GA + AA genotypes; OR = 3...
2017: Journal of Diabetes Research
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