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https://www.readbyqxmd.com/read/28088110/highly-sensitive-detection-of-cysteine-over-glutathione-and-homo-cysteine-new-insight-into-the-michael-addition-of-mercapto-group-to-maleimide
#1
Zhaoyang Chen, Qian Sun, Yuhua Yao, Xiaoxiang Fan, Weibing Zhang, Junhong Qian
A fluorescence "off-on" probe CMP for thiols was designed with coumarin as the fluorophore and maleimide as the receptor. The fluorescence of the coumarin was quenched through photoinduced electron transfer (PET) from the fluorophore to maleimide group. The Michael addition of the mercapto group toward maleimide formed a thioether with relatively weak fluorescence. The intramolecular nucleophilic substitution of amino group in cysteine (Cys) to alkylthio produced a much stronger fluorescent amino adduct, which was supported by UPLC-MS and NMR titration...
January 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28087280/increased-homocysteine-levels-impair-reference-memory-and-reduce-cortical-levels-of-acetylcholine-in-a-mouse-model-of-vascular-cognitive-impairment
#2
Kevin Dam, Martina Füchtemeier, Tracy D Farr, Philipp Boehm-Sturm, Marco Foddis, Ulrich Dirnagl, Olga Malysheva, Marie A Caudill, Nafisa M Jadavji
Folates are B-vitamins that are vital for normal brain function. Deficiencies in folates either genetic (methylenetetrahydrofolate reductase, MTHFR) or dietary intake of folic acid result in elevated levels of homocysteine. Clinical studies have shown that elevated levels of homocysteine (Hcy) may be associated with the development of dementia, however this link remains unclear. The purpose of this study was to evaluate the impact of increased Hcy levels on a mouse model of vascular cognitive impairment (VCI) produced by chronic hypoperfusion...
January 11, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28071971/neuropsychological-implications-of-cobalamin-c-cblc-disease-in-hispanic-children-detected-through-newborn-screening
#3
Ashley M Whitaker, Nina Hattiangadi Thomas, Lauren S Krivitzky, Can H Ficicioglu
Cobalamin C (CblC) disease is the most common inborn error of cobalamin metabolism and recent data has indicated a higher prevalence among children of Hispanic heritage in particular. The purpose of this study was to (a) describe the neuropsychological characteristics of a pilot sample of Hispanic children with CblC disease and (b) explore potential differences in outcome based on underlying genetic mutation(s) and biochemical levels. Six Hispanic children (ages 2-10) diagnosed with CblC disease through newborn screening (NBS) underwent neuropsychological evaluation with a bilingual examiner...
January 10, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/28059419/a-mitochondria-targeting-fluorescent-probe-for-the-selective-detection-of-glutathione-in-living-cells
#4
Xue-Liang Liu, Li-Ya Niu, Yu-Zhe Chen, Mei-Ling Zheng, Yunxu Yang, Qing-Zheng Yang
We report a fluorescent probe for the selective detection of mitochondrial glutathione (GSH). The probe, containing triphenylphosphine as a mitochondrial targeting group, exhibited ratiometric and selective detection of GSH over Cys/Hcy. The probe was used for imaging mitochondrial GSH in living HeLa cells.
January 6, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28050421/the-effect-of-folic-acid-supplementation-on-hyperhomocysteinemia-and-pulmonary-function-parameters-in-chronic-obstructive-pulmonary-disease-a-pilot-study
#5
Naushad Ahmad Khan, Harish Saini, Govind Mawari, Suman Kumar, Harmanjit Singh Hira, Mradul Kumar Daga
INTRODUCTION: Preliminary studies have established the elevated plasma total Homocysteine (tHcy) levels as a risk factor for Chronic Obstructive Pulmonary Disease (COPD). However, studies describing plasma tHcy levels and their relationship to folic acid supplementation and Forced Expiratory Volume in 1 Second (FEV1) status in COPD patients are still lacking. AIM: We investigated the role of hyperhomocysteinemia in COPD and then prospectively examined the relationship between plasma tHcy concentration and effect of folic acid supplementation on FEV1 status in COPD patients...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28034716/dichotomous-effects-of-isomeric-secondary-amines-containing-an-aromatic-nitrile-and-nitro-group-on-human-aortic-smooth-muscle-cells-via-inhibition-of-cystathionine-%C3%AE-lyase
#6
Yajing Ji, Austin Bowersock, Alec R Badour, Neeraj Vij, Stephen J Juris, David E Ash, Dillip K Mohanty
Excessive proliferation of vascular smooth muscle cells (SMC) is an important contributor to the progression of atherosclerosis. Inhibition of proliferation can be achieved by endogenously produced and exogenously supplied nitrogen monoxide, commonly known as nitric oxide (NO). We report herein the dichotomous effects of two isomeric families of secondary amines, precursors to the N-nitrosated NO-donors, on HASMC proliferation. The syntheses of these two families were carried out using two equivalents of homologous, aliphatic monoamines and 2,6-difluoro-3-nitrobenzonitrile (2,6-DFNBN, O family) or 2,4-difluoro-5-nitrobenzonitrile (2,4-DFNBN, P family)...
December 26, 2016: Biochimie
https://www.readbyqxmd.com/read/28030819/hyperhomocysteinemia-results-from-and-promotes-hepatocellular-carcinoma-via-cyp450-metabolism-by-cyp2j2-dna-methylation
#7
Donghong Zhang, Jinli Lou, Xu Zhang, Lin Zhang, Fei Wang, Danfei Xu, Na Niu, Yidong Wang, Yue Wu, Wei Cui
Hyperhomocysteinemia (HHcy) can result from liver disease or dysfunction and further alters intracellular lipid metabolism. Cytochrome P450 (CYP) arachidonic acid epoxygenases are expressed in human cancers and promote cancer metastasis. This study explored the interaction of Hcy and CYP450 metabolism in hepatocellular carcinoma (HCC). The levels of 4-epoxyeicosatrienoic acid (EET) isomers and their generative enzyme CYP2J2 level as well as intracellular Hcy level were higher in 42 cases of HCC than in paired non-tumor tissue...
December 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/28029114/folate-and-vitamin-b12-related-biomarkers-in-relation-to-brain-volumes
#8
Nikita L van der Zwaluw, Elske M Brouwer-Brolsma, Ondine van de Rest, Janneke P van Wijngaarden, Paulette H In 't Veld, Daniella I Kourie, Karin M A Swart, Anke W Enneman, Suzanne C van Dijk, Nathalie van der Velde, Roy P C Kessels, Paul A M Smeets, Frans J Kok, Rosalie A M Dhonukshe-Rutten, Lisette C P G M de Groot
AIM: We investigated cross-sectional associations between circulating homocysteine, folate, biomarkers of vitamin B12 status and brain volumes. We furthermore compared brain volumes of participants who received daily folic acid and vitamin B12 supplementation with participants who did not. METHODS: Participants of the B-PROOF study (n = 2919) were assigned to 400 µg folic acid and 500 µg vitamin B12, or a placebo. After two years of intervention, T₁-weighted magnetic resonance imaging (MRI) scans were made in a random subsample (n = 218) to obtain grey and white matter volume, and total brain volume (TBV)...
December 24, 2016: Nutrients
https://www.readbyqxmd.com/read/28028785/disturbed-nitric-oxide-and-homocysteine-production-are-involved-in-the-increased-risk-of-cardiovascular-diseases-in-the-f1-offspring-of-maternal-obesity-and-malnutrition
#9
Y Y Moussa, S H Tawfik, M M Haiba, M I Saad, M Y Hanafi, T M Abdelkhalek, G A Oriquat, M A Kamel
PURPOSE: The present study aimed to evaluate the changes in levels of different independent risk factors for vascular diseases in the rat offspring of maternal obesity and malnutrition as maternal health disturbances are thought to have direct consequences on the offspring health. The effect of postnatal diet on the offspring was also assessed. METHODS: Three groups of female Wistar rats were used (control, obese and malnourished). After the pregnancy and delivery, the offspring were weaned to control diet or high-caloric (HCD) diet and followed up for 30 weeks...
December 27, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28004436/vein-graft-disease-in-a-knockout-mouse-model-of-hyperhomocysteinaemia
#10
Christina Maria Steger, Tobias Mayr, Nikolaos Bonaros, Johannes Bonatti, Thomas Schachner
A major reason for vein graft failure after coronary artery bypass grafting is neointimal hyperplasia and thrombosis. Elevated serum levels of homocysteine (Hcy) are associated with higher incidence of cardiovascular disease, but homocysteine levels also tend to increase during the first weeks or months after cardiac surgery. To investigate this further, C57BL/6J mice (WT) and cystathionine-beta-synthase heterozygous knockout mice (CBS+/-), a mouse model for hyperhomocysteinaemia, underwent interposition of the vena cava of donor mice into the carotid artery of recipient mice...
December 22, 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28003096/conformational-status-of-cytochrome-c-upon-n-homocysteinylation-implications-to-cytochrome-c-release
#11
Gurumayum Suraj Sharma, Laishram Rajendrakumar Singh
One of the proposed mechanisms of homocysteine (Hcy) toxicity is the post-translational modification of proteins by its metabolite, homocysteine thiolactone (HTL). Incubation of proteins with HTL has been shown to form covalent adducts with ε-amino group of lysine residues of protein (called N-homocysteinylation) which ultimately results in structural and functional alterations of the modified proteins. In the present study, the effects of HTL on the conformational and heme status of cytochrome c (cyt c) were investigated...
January 15, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27995792/ph-dependent-fluorescent-probe-that-can-be-tuned-for-cysteine-or-homocysteine
#12
Yongkang Yue, Fangjun Huo, Xiaoqi Li, Ying Wen, Tao Yi, James Salamanca, Jorge O Escobedo, Robert M Strongin, Caixia Yin
The very close structural similarities between cysteine and homocysteine present a great challenge to achieve their selective detection using regular fluorescent probes, limiting the biological and pathological studies of these two amino thiols. A coumarin-based fluorescent probe was designed featuring pH-promoted distinct turn-on followed by ratiometric fluorescence responses for Cys and turn-on fluorescence response for Hcy through two different reaction paths. These specific responses demonstrate the activity differences between Cys and Hcy qualitatively for the first time...
December 20, 2016: Organic Letters
https://www.readbyqxmd.com/read/27995330/piceatannol-attenuates-homocysteine-induced-endoplasmic-reticulum-stress-and-endothelial-cell-damage-via-heme-oxygenase-1-expression
#13
Jin-Sang Kil, Sun-Oh Jeong, Hun-Taeg Chung, Hyun-Ock Pae
A growing body of evidence implicates endoplasmic reticulum (ER)-induced cellular dysfunction and apoptosis as important factors to a variety of diseases. In endothelial cells (ECs), the sulfur-containing amino acid homocysteine (Hcy) causes EC apoptosis and reactive oxygen species (ROS) generation through induction of ER stress. Here, we have investigated whether piceatannol (Pic), a resveratrol analog, could protect ECs against Hcy-induced apoptosis, oxidative stress and ER stress, with specific emphasis on heme oxygenase-1 (HO-1)...
December 20, 2016: Amino Acids
https://www.readbyqxmd.com/read/27993685/simvastatin-inhibits-homocysteine-induced-crp-generation-via-interfering-with-the-ros-p38-erk1-2-signal-pathway-in-rat-vascular-smooth-muscle-cells
#14
Xiaoming Pang, Jigang Si, Shouzhu Xu, Yuxia Li, Juntian Liu
Inflammation plays a pivotal role throughout the formation and progression of atherosclerosis. As the most representative inflammatory marker, C-reactive protein (CRP) directly participates in the initiation and development of atherosclerosis. The elevated homocysteine (Hcy) level in plasma is an independent risk factor for atherosclerosis. We previously reported that Hcy produces a pro-inflammatory effect by stimulating CRP expression in vascular smooth muscle cells (VSMCs). The present study observed the effect of simvastatin on Hcy-induced CRP expression in VSMCs and the molecular mechanisms...
January 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/27988490/hydrogen-sulfide-ameliorates-homocysteine-induced-cognitive-dysfunction-by-inhibition-of-reactive-aldehydes-involving-upregulation-of-aldh2
#15
Min Li, Ping Zhang, Hai-Jun Wei, Man-Hong Li, Wei Zou, Xiang Li, Hong-Feng Gu, Xiao-Qing Tang
BACKGROUND: Homocysteine, a risk factor for Alzheimer's disease, induces cognitive dysfunction. Reactive aldehydes play an important role in cognitive dysfunction. Aldehyde-dehydrogenase 2 detoxifies reactive aldehydes. Hydrogen sulfide, a novel neuromodulator, has neuroprotective effects and regulates learning and memory. Our previous work confirmed that the disturbance of hydrogen sulfide synthesis is invovled in homocysteine-induced defects in learning and memory. Therefore, the present work was to explore whether hydrogen sulfide ameliorates homocysteine-generated cognitive dysfunction and to investigate whether its underlying mechanism is related to attenuating accumulation of reactive aldehydes by upregulation of aldehyde-dehydrogenase 2...
December 19, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27981743/whey-protein-isolate-improves-vitamin-b12-and-folate-status-in-elderly-australians-with-sub-clinical-deficiency-of-vitamin-b12
#16
Varinderpal S Dhillon, Dimitrios Zabaras, Theodora Almond, Paul Cavuoto, Genevieve James-Martin, Michael Fenech
SCOPE: Whey protein isolate (WPI) contains vitamin B12 and folate. However, the efficacy of WPI as a bio-available source of these vitamins in the elderly with low vitamin B12 was not previously tested. We investigated the effects of WPI supplementation on vitamin B12 and folate status in blood and measured changes in homocysteine, methylmalonic acid and genome integrity biomarkers in elderly individuals with low vitamin B12 status. The effect of WPI was compared to soy protein isolate (SPI)...
December 16, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27979431/prognostic-value-of-c-reactive-protein-and-homocysteine-in-large-artery-atherosclerotic-stroke-a-prospective-observational-study
#17
Zusen Ye, Zhizhong Zhang, Hao Zhang, Yonggang Hao, Jun Zhang, Wenhua Liu, Gelin Xu, Xinfeng Liu
BACKGROUND: Our objective is to investigate whether C-reactive protein (CRP) and homocysteine (Hcy) levels in the acute phase of large-artery atherosclerotic stroke predict long-term functional disability and recurrent vascular events. METHODS: Patients with first-ever large-artery atherosclerotic ischemic stroke were prospectively registered in the Nanjing Stroke Registry Program between January 2012 and June 2014. Venous blood samples were collected within 2 weeks after the index stroke...
December 12, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27976866/highly-selective-fluorescent-probe-for-imaging-h2se-in-living-cells-and-in-vivo-based-on-the-disulfide-bond
#18
Fanpeng Kong, Yuehui Zhao, Ziye Liang, Xiaojun Liu, Xiaohong Pan, Dongrui Luan, Kehua Xu, Bo Tang
Hydrogen selenide (H2Se) is an important metabolite of dietary Se compounds and has been implicated in various pathological and physiological processes. The development of highly sensitive and selective methods for the sensing of H2Se is therefore very important. Herein, we developed a fluorescent probe (hemicyanine (Hcy)-H2Se) for detecting H2Se based on a new H2Se-specific receptor unit, 1,2-dithiane-4,5-diol. Hcy-H2Se showed high selectivity toward H2Se over thiols (RSH), hydrogen sulfide (H2S), and selenocysteine (Sec) and was further exploited for the fluorescence imaging of H2Se both in living cells and in vivo...
December 15, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27973469/analysis-of-metabolism-related-indicators-and-mthfr-gene-polymorphism-in-patients-with-h-type-hypertension
#19
Zhi Tang, Ling Xiao, Ji Q Wang, Tao Zhang
OBJECTIVE: This study aims to analyze the polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene in patients with hypertension, and explore the correlation between H-type hypertension and metabolic biochemical indicators such as homocysteine (Hcy). METHODS: 100 patients with H-type hypertension and 100 patients with common hypertension were selected as the study subjects. Plasma Hcy and blood lipids, blood glucose, and other biochemical indicators were detected in the two groups...
December 14, 2016: Minerva Medica
https://www.readbyqxmd.com/read/27973419/potential-links-between-impaired-one-carbon-metabolism-due-to-polymorphisms-inadequate-b-vitamin-status-and-the-development-of-alzheimer-s-disease
#20
REVIEW
Barbara Troesch, Peter Weber, M Hasan Mohajeri
Alzheimer's disease (AD) is the major cause of dementia and no preventive or effective treatment has been established to date. The etiology of AD is poorly understood, but genetic and environmental factors seem to play a role in its onset and progression. In particular, factors affecting the one-carbon metabolism (OCM) are thought to be important and elevated homocysteine (Hcy) levels, indicating impaired OCM, have been associated with AD. We aimed at evaluating the role of polymorphisms of key OCM enzymes in the etiology of AD, particularly when intakes of relevant B-vitamins are inadequate...
December 10, 2016: Nutrients
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