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https://www.readbyqxmd.com/read/29140850/hepatocellular-carcinoma-with-bile-duct-tumor-thrombus-extrahepatic-bile-duct-preserving-or-not-reply
#1
Kiyoshi Hasegawa, Satoshi Yamamoto, Yousuke Inoue, Junichi Shindoh, Taku Aoki, Yoshihiro Sakamoto, Yasuhiko Sugawara, Norihiro Kokudo, Masatoshi Makuuchi
No abstract text is available yet for this article.
December 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29139047/stereotactic-navigation-during-laparoscopic-surgery-for-locally-recurrent-rectal-cancer
#2
K Kawada, S Hasegawa, T Okada, K Hida, T Okamoto, Y Sakai
No abstract text is available yet for this article.
November 14, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29138788/3d-tem-study-on-the-novel-bicontinuous-microdomain-structure
#3
Yi-Chin Wang, Midori Wakabayashi, Hirokazu Hasegawa, Mikihito Takenaka
An ordered bicontinuous double-diamond (OBDD) morphology was found in polystyrene-block-(poly-4-vinylphenyldimethylvinylsilane-graft-polyisoprene), PS-b-(PVS-g-PI), block-graft copolymer. We obtained a 3D image of the microdomain structure formed in PS-b-(PVS-g-PI) using 3D-TEM. The 3D image shows that the polystyrene (PS) phase consists of two independent and interwoven networks. The structures of the two networks are identical and include tetrapod units that form planar six-membered rings. The features of the networks agree with those in the OBDD morphology, indicating that PS-b-(PVS-g-PI) exhibits ordered three-dimensional OBDD networks with the PS phase in the polyisoprene (PI) matrix phase...
November 15, 2017: Soft Matter
https://www.readbyqxmd.com/read/29138378/-body-surface-area-formulas-for-the-calculation-of-the-chemotherapy-dosage
#4
Haruna Hatahira, Kazuhiro Iguchi, Sayaka Sasaoka, Yumi Motooka, Shiori Hasegawa, Misa Naganuma, Akiho Fukuda, Tomofumi Ohmori, Tatsuhiko Yoshida, Kaoru Mogushi, Mitsuhiro Nakamura
Body surface area(BSA)is a parameter frequently used to calculate the chemotherapy dosage. Several different equations for predicting BSA have been developed. We examined the formula suggested for BSA calculation for 62 chemotherapy drugs where the recommended dosage was based on patient BSA. We found that the description of the formula to be used for BSA calculation was not provided in the package inserts or in the drug interview forms in the majority of cases; the BSA formula was mentioned in the guide for appropriate use of medication in only 8 of 62 chemotherapy drugs...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29138019/a-patient-with-severe-fever-with-thrombocytopenia-syndrome-and-hemophagocytic-lymphohistiocytosis-associated-involvement-of-the-central-nervous-system
#5
Kaneko Masahiko, Shikata Hisaharu, Matsukage Shoichi, Maruta Masaki, Shinomiya Hiroto, Suzuki Tadaki, Hasegawa Hideki, Shimojima Masayuki, Saijo Masayuki
Severe fever with thrombocytopenia syndrome (SFTS), a severe infectious disease caused by novel bunyavirus, SFTS virus (SFTSV), is endemic to China, Korea, and Japan. Most SFTS patients show abnormalities in consciousness. Pathological findings in the central nervous system (CNS) of SFTS patients are not reported. A 53-year-old Japanese man was admitted to Uwajima City Hospital with an 8-day history of fever and diarrhea. Laboratory tests revealed leukopenia, thrombocytopenia, and liver enzyme elevation. He was diagnosed as having severe fever with thrombocytopenia syndrome (SFTS) following detection of the SFTSV genome in his blood...
November 11, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29137983/transcriptional-regulation-of-acetoacetyl-coa-synthetase-by-sp1-in-neuroblastoma-cells
#6
Shinya Hasegawa, Masahiko Imai, Masahiro Yamasaki, Noriko Takahashi, Tetsuya Fukui
Acetoacetyl-CoA synthetase (AACS) is the enzyme responsible for cholesterol and fatty acid synthesis in the cytosol. We have previously shown that AACS has an important role in normal neuronal development and that knockdown of SREBP-2, which orchestrates cholesterol synthesis, resulted in the downregulation of AACS mRNA levels. In this study, we investigated the transcriptional mechanism of AACS in Neuro-2a, neuroblastoma cells. Luciferase assay showed that the minimal core promoter of the mouse AACS gene is located in a region with 110 bps upstream from the transcription start site...
November 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29136323/increasing-canopy-photosynthesis-in-rice-can-be-achieved-without-a-large-increase-in-water-use-a-model-based-on-free-air-co2-enrichment
#7
Hiroki Ikawa, Charles P Chen, Martin Sikma, Mayumi Yoshimoto, Hidemitsu Sakai, Takeshi Tokida, Yasuhiro Usui, Hirofumi Nakamura, Keisuke Ono, Atsushi Maruyama, Tsutomu Watanabe, Tsuneo Kuwagata, Toshihiro Hasegawa
Achieving higher canopy photosynthesis rates is one of the keys to increasing future crop production; however, this typically requires additional water inputs because of increased water loss through the stomata. Lowland rice canopies presently consume a large amount of water, and any further increase in water usage may significantly impact local water resources. This situation is further complicated by changing environmental conditions such as rising atmospheric CO2 concentration ([CO2 ]). Here we modeled and compared evapotranspiration of fully developed rice canopies of a high-yielding rice cultivar (Oryza sativa L...
November 14, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29135497/pancreatic-chymotrypsin-activity-rather-than-amylase-level-better-predicts-postoperative-pancreatic-fistula
#8
Suguru Yamashita, Takeaki Ishizawa, Kazuhiro Mori, Kazuteru Monden, Yugo Kuriki, Mako Kamiya, Junichi Kaneko, Nobuhisa Akamatsu, Junichi Arita, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Yasuteru Urano, Norihiro Kokudo
OBJECTIVE: To assess the predictive value of chymotrypsin activity in pancreatic juice on clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreatic resection, since pancreatic peptidases rather than glycolytic enzymes play a pivotal role in causing tissue damage due to pancreatic leakage. BACKGROUND: The risk of CR-POPF has been estimated based on amylase level in abdominal drainage fluid. METHODS: Eighty-one consecutive patients underwent pancreatoduodenectomy, and postoperative pancreatic juice and drainage fluids were collected for 14 days...
November 13, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29134329/esophageal-motility-disorders-new-perspectives-from-high-resolution-manometry-and-histopathology
#9
REVIEW
Hiroki Sato, Kazuya Takahashi, Ken-Ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Go Hasegawa, Shuji Terai
High-resolution manometry (HRM) and peroral endoscopic myotomy (POEM) have contributed significantly to the field of esophageal motility disorders in recent years. The development of HRM has categorized various esophageal motility disorders with a focus on a diverse range of manometric anomalies. Additionally, the Chicago classification criteria is widely used for manometric diagnosis. Moreover, POEM was introduced as a minimally invasive radical therapy for achalasia and shows promise for other spastic esophageal motility disorders as well...
November 13, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29133584/asymptomatic-contrast-medium-extravasation
#10
Yoh Arita, Shouta Bun, Takatsugu Segawa, Shinji Hasegawa
No abstract text is available yet for this article.
November 12, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29132799/surgical-exploration-for-impalpable-testis-which-should-be-first-inguinal-exploration-or-laparoscopic-abdominal-exploration
#11
Akihiro Igarashi, Kenta Kikuchi, Kenjiro Ogushi, Mariko Hasegawa, Masahiro Hatanaka, Junko Fujino, Yoko Kishi, Hitoshi Ikeda
PURPOSE: To discuss an optimal surgical approach for impalpable testis in children, our own treatment results and those reported in the literature were reviewed. MATERIALS AND METHODS: Seventy-two impalpable testes were diagnosed in 68 patients: unilateral in 64 patients and bilateral in 4 patients. All patients underwent surgical exploration at the ages of 6 to 140months (median, 15months). The inguinal canal was initially explored, and abdominal exploration was performed with laparoscopy when an extra-abdominal testis was not identified...
October 16, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29131458/image-analysis-is-an-excellent-tool-for-quantifying-ki-67-to-predict-the-prognosis-of-gastrointestinal-stromal-tumor-patients
#12
Shintaro Sugita, Hiroshi Hirano, Yutaka Hatanaka, Hiromi Fujita, Terufumi Kubo, Noriaki Kikuchi, Yumika Ito, Taro Sugawara, Keiko Segawa, Hiroyuki Hisai, Kentaro Yamashita, Takayuki Nobuoka, Yoshihiro Matsuno, Tadashi Hasegawa
We investigated the quantification of Ki-67 staining using digital image analysis (IA) as a complementary prognostic factor to the modified National Institutes of Health (NIH) classification in patients with gastrointestinal stromal tumor (GIST). We examined 92 patients, focusing on the correlation between age, sex, primary tumor site, tumor size, predominant histologic type, mitotic index, modified NIH classification (low/intermediate vs high), Ki-67 quantitation, and recurrence-free survival (RFS). We compared two IA processes for whole slide imaging (WSI) and manually captured image (MCI) methods...
November 13, 2017: Pathology International
https://www.readbyqxmd.com/read/29129879/transcatheter-aortic-valve-implantation-for-degenerated-19-mm-aortic-bioprosthetic-valve
#13
Kizuku Yamashita, Tomoyuki Fujita, Satsuki Fukushima, Yusuke Shimahara, Yuta Kume, Yorihiko Matsumoto, Naonori Kawamoto, Tatsuro Hitsumoto, Nobuyasu Ito, Yasuhiro Hamatani, Atsushi Okada, Hiroyuki Takahama, Makoto Amaki, Takuya Hasegawa, Yasuo Sugano, Hideaki Kanzaki, Toshihisa Anzai, Satoshi Yasuda, Junjiro Kobayashi
BACKGROUND: The valve-in-valve procedure, in which a transcatheter heart valve (THV) is implanted over a prosthetic valve, has been shown to be safe and therapeutically effective, depending on the size of the replacement valve.Methods and Results:We report 3 cases of successful valve-in-valve procedure to replace a degenerated 19-mm stented prosthetic aortic valve. Balloon-expanding THVs were implanted: 20-mm in the 1st case and 23-mm in the next 2. Aortic stenosis was almost completely resolved in all patients, who recovered promptly and without cardiac adverse events...
November 11, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29129645/incretins-modulate-progesterone-biosynthesis-by-regulating-bone-morphogenetic-protein-activity-in-rat-granulosa-cells
#14
Yuki Nishiyama, Toru Hasegawa, Shiho Fujita, Nahoko Iwata, Satoko Nagao, Takeshi Hosoya, Kenichi Inagaki, Jun Wada, Fumio Otsuka
The effects of incretins on ovarian steroidogenesis have not been clarified. In this study, we investigated the effects of incretins, including GIP and GLP-1, on ovarian steroidogenesis using rat primary granulosa cells. Treatment with incretins significantly suppressed progesterone synthesis in the presence of FSH, and the effect of GIP was more potent than that of GLP-1. In contrast, incretins had no significant effect on estrogen synthesis by rat granulosa cells. In accordance with the effects of incretins on steroidogenesis, GIP and GLP-1 suppressed the expression of progesterogenic factors and enzymes, including StAR, P450scc, 3βHSD, but not P450arom, and cellular cAMP synthesis induced by FSH...
November 9, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29127775/four-dimensional-computed-tomography-evaluation-of-condylar-movement-in-a-patient-with-temporomandibular-joint-osteoarthritis
#15
Masaya Akashi, Takumi Hasegawa, Satoru Takahashi, Takahide Komori
Temporomandibular joint (TMJ) osteoarthritis (OA) is a disease of the bone, cartilage, and supporting tissues of the joint. Patients with advanced TMJ-OA often have symptoms such as pain, swelling, and joint dysfunction, and they sometimes require surgical intervention when conservative treatment is not effective. The etiology of TMJ-OA remains elusive. The usefulness of 4-dimensional (4D) computed tomography (CT) in motion analysis of various joints has recently been reported. This article introduces a novel imaging technique of 4D CT that aims to identify kinematic features that may be associated with the etiology of TMJ-OA...
October 16, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29127066/surface-modifications-and-oxidative-degradation-in-mpc-grafted-highly-cross-linked-polyethylene-liners-retrieved-from-short-term-total-hip-arthroplasty
#16
Shine Tone, Masahiro Hasegawa, Leonardo Puppulin, Giuseppe Pezzotti, Akihiro Sudo
Highly cross-linked polyethylene (HXLPE) hip liners grafted with 2-methacryloyloxyethyl phosphorylcholine (MPC) on their bearing surfaces have recently been commercialized as components of a new generation of artificial hip joints, while improvements in wear resistance and biocompatibility were reported based on in vitro studies. The present study aimed at evaluating the surface modification and oxidative degradation in short-term retrieved MPC-grafted liners by X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared spectroscopy (FT-IR) with attenuated total reflection (ATR) equipment and Raman spectroscopy...
November 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29127021/severe-delayed-haemolytic-anaemia-associated-with-artemether-lumefantrine-treatment-of-malaria-in-a-japanese-traveller
#17
Chihiro Hasegawa, Masaharu Kudo, Haruhiko Maruyama, Mikio Kimura
Delayed haemolytic anaemia has been reported in association with intravenous artesunate treatment in patients with severe Plasmodium falciparum malaria, and furthermore, oral artemisinin-based combination therapies including artemether-lumefantrine (AL) have also been incriminated. However, definite cases of delayed haemolytic anaemia associated with AL appear to be scarce, as reported cases were often treated concomitantly with other anti-malarials. In this study, we report a severe case of delayed haemolytic anaemia following AL alone in a Japanese traveller with severe parasitaemia caused by numerous P...
November 7, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29126235/clinical-significance-of-interferon-%C3%AE-neutralizing-autoantibodies-against-disseminated-nontuberculous-mycobacterial-disease
#18
Ami Aoki, Takuro Sakagami, Kazutaka Yoshizawa, Kenjiro Shima, Mio Toyama, Yoshinari Tanabe, Hiroshi Moro, Nobumasa Aoki, Satoshi Watanabe, Toshiyuki Koya, Takashi Hasegawa, Kozo Morimoto, Atsuyuki Kurashima, Yoshihiko Hoshino, Bruce C Trapnell, Toshiaki Kikuchi
Background: Interferon-γ neutralizing autoantibodies (nIFNγ-autoAb) are reported in patients with disseminated nontuberculous mycobacteria (NTM) infection and may function by increasing the infection risk. Notwithstanding, the prevalence of nIFNγ-autoAb as well as the clinical presentation, diagnosis, and natural history, of disseminated NTM infection in these patients is poorly understood. Methods: In this retrospective observational study, data and sera for 331 Japanese subjects with mycobacterial infection were collected and analyzed...
November 8, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29124401/bronchoscopic-assessments-and-clinical-outcomes-in-pediatric-patients-with-tracheomalacia-and-bronchomalacia
#19
Yuichi Okata, Tomomi Hasegawa, Yuko Bitoh, Kosaku Maeda
BACKGROUND: Tracheomalacia and bronchomalacia (TM/BM) are one of the serious causes of airway obstruction in infants and children. This study reviewed our bronchoscopic assessments and clinical outcomes in pediatric patients with TM/BM, and investigated risk factors of surgical intervention for TM/BM. METHODS: Fifty-seven consecutive patients who were diagnosed as TM/BM by bronchoscopy between 2009 and 2013 were reviewed retrospectively. They were divided into two groups according to the presence (group E, n = 26) or absence (group N, n = 31) of acute life-threatening events and extubation failure (ALTE/EF)...
November 9, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29123838/prehospital-triage-for-endovascular-clot-removal-in-acute-stroke-patients
#20
Yu Suzuki, Yasuhiro Hasegawa, Kohtaro Tsumura, Toshihiro Ueda, Kazunari Suzuki, Makoto Sugiyama, Hiroyuki Nozaki, Shojiro Kawaguchi, Makoto Nakane, Goro Nagashima, Takayuki Kitamura, Kengo Yokomine, Jinichi Sasanuma
Aim: To establish prehospital triage in accordance with the new guidelines for endovascular therapy, we retrospectively analyzed the monitoring data of the city-wide transportation system using the Maria Prehospital Stroke Scale (MPSS), a novel prehospital stroke scale for emergency medical technicians (EMTs) to predict the likelihood of thrombolytic therapy after transportation. Methods: Kawasaki City, Japan, has six comprehensive stroke centers (CSCs) and six primary stroke centers (PSCs)...
January 2017: Acute Medicine & Surgery
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