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https://www.readbyqxmd.com/read/29789840/prominent-hydrogenation-catalysis-of-a-pvp-stabilized-au-34-superatom-provided-by-doping-a-single-rh-atom
#1
Shingo Hasegawa, Shinjiro Takano, Seiji Yamazoe, Tatsuya Tsukuda
A single rhodium atom was precisely doped into a gold cluster Au34 stabilized by poly(N-vinyl-2-pyrrolidone) (Au:PVP) as revealed by mass spectrometry. The Rh-atom-doped Au:PVP exhibited remarkable catalytic activity for hydrogenation reactions of olefins, which was much higher than that of recently reported Pd-atom-doped Au:PVP.
May 23, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29786758/long-term-complete-remission-following-tandem-autologous-stem-cell-transplantation-and-consolidative-radiotherapy-for-refractory-mediastinal-gray-zone-lymphoma
#2
Koji Takaishi, Tomoya Muto, Naoya Mimura, Jun Takiguchi, Yuhei Nagao, Nagisa Oshima-Hasegawa, Shokichi Tsukamoto, Yusuke Takeda, Shio Mitsukawa, Masahiro Takeuchi, Chikako Ohwada, Satoshi Ota, Tohru Iseki, Chiaki Nakaseko, Emiko Sakaida
Mediastinal gray zone lymphoma (MGZL) is a provisional entity with intermediate features between classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma. Outcomes for patients with MGZL are reportedly poorer than those for patients with cHL or primary mediastinal large B-cell lymphoma. Additionally, no standard management guidelines for patients with MGZL are available, primarily due to its recent identification, rarity, and challenges in diagnosis. Although recent several studies have suggested dose-adjusted EPOCH-R (etoposide, doxorubicin, vincristine, cyclophosphamide, prednisolone, and rituximab) may improve outcomes in patients with MGZL, numerous patients still suffer from relapsed/refractory MGZL, and the optimal management for such patients remains uncertain...
May 21, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29781948/outcomes-of-pediatric-abo-incompatible-living-kidney-transplantations-from-2002-to-2015-an-analysis-of-the-japanese-kidney-transplant-registry
#3
Motoshi Hattori, Makiko Mieno, Seiichiro Shishido, Atsushi Aikawa, Hidetaka Ushigome, Shinichi Ohshima, Kota Takahashi, Akira Hasegawa
BACKGROUND: Extensive data have been accumulated for adults who have undergone ABO-incompatible (ABOi)-living kidney transplantation (LKT). In contrast, available published data on pediatric recipients who underwent ABOi-LKT from the early to middle 2000s is very limited. Thus, pediatric ABOi-LKT has remained relatively rare and there is a lack of large, multicenter data. METHODS: We analyzed data from the Japanese Kidney Transplant Registry to clarify the patient and graft outcomes of pediatric recipients who underwent ABOi-LKT from 2002 to 2015...
April 30, 2018: Transplantation
https://www.readbyqxmd.com/read/29781797/from-plants-to-nematodes-serratia-grimesii-bxf1-genome-reveals-an-adaptation-to-the-modulation-of-multi-species-interactions
#4
Francisco Nascimento, Cláudia Vicente, Peter Cock, Maria Tavares, Márcio Rossi, Koichi Hasegawa, Manuel Mota
Serratia grimesii BXF1 is a bacterium with the ability to modulate the development of several eukaryotic hosts. Strain BXF1 was isolated from the pinewood nematode, Bursaphelenchus xylophilus, the causative agent of pine wilt disease affecting pine forests worldwide. This bacterium potentiates Bursaphelenchus xylophilus reproduction, acts as a beneficial pine endophyte, and possesses fungal and bacterial antagonistic activities, further indicating a complex role in a wide range of trophic relationships. In this work, we describe and analyse the genome sequence of strain BXF1, and discuss several important aspects of its ecological role...
May 21, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29781615/superconductivity-of-rocksalt-structure-lao-epitaxial-thin-film
#5
Kenichi Kaminaga, Daichi Oka, Tetsuya Hasegawa, Tomoteru Fukumura
We report superconducting transition in LaO epitaxial thin film with the onset of superconducting transition temperature ( Tc ) at around 5 K. The Tc is the highest among lanthanum monochalcogenides opposite to the chemical trend of their Tc : 0.84, 1.02, and 1.48 K for La X ( X = S, Se, Te), respectively. The carrier control resulted in a dome-shaped Tc as a function of electron carrier density. In addition, the Tc was significantly sensitive to epitaxial strain in spite of its highly symmetric crystal structure...
May 21, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29779930/a-sialylated-voltage-dependent-ca-2-channel-binds-hemagglutinin-and-mediates-influenza-a-virus-entry-into-mammalian-cells
#6
Yoichiro Fujioka, Shinya Nishide, Toyoyuki Ose, Tadaki Suzuki, Izumi Kato, Hideo Fukuhara, Mari Fujioka, Kosui Horiuchi, Aya O Satoh, Prabha Nepal, Sayaka Kashiwagi, Jing Wang, Mika Horiguchi, Yuko Sato, Sarad Paudel, Asuka Nanbo, Tadaaki Miyazaki, Hideki Hasegawa, Katsumi Maenaka, Yusuke Ohba
Influenza A virus (IAV) infection is initiated by the attachment of the viral glycoprotein hemagglutinin (HA) to sialic acid on the host cell surface. However, the sialic acid-containing receptor crucial for IAV infection has remained unidentified. Here, we show that HA binds to the voltage-dependent Ca2+ channel Cav 1.2 to trigger intracellular Ca2+ oscillations and subsequent IAV entry and replication. IAV entry was inhibited by Ca2+ channel blockers (CCBs) or by knockdown of Cav 1.2. The CCB diltiazem also inhibited virus replication in vivo...
May 10, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29778543/expression-of-a-functional-intrabody-against-hepatitis-c-virus-core-protein-in-escherichia-coli-and-silkworm-pupae
#7
Tatsuya Kato, Moeko Hasegawa, Takeshi Yamamoto, Takatsugu Miyazaki, Ryosuke Suzuki, Takaji Wakita, Tetsuro Suzuki, Enoch Y Park
It has been shown that the single-domain intrabody 2H9-L against the hepatitis C virus (HCV) capsid (core) protein inhibits the viral propagation and NF-κB promoter activity induced by the HCV core. In this study, 2H9-L fused with the FLAG tag sequence was expressed in both Escherichia coli and silkworm pupae and then purified. In addition, the full-length and its C terminal deletions of the HCV core protein, i.e., 1-123 amino acid residues (C123), 1-152 amino acid residues (C152), 1-177 amino acid residues (C177) and 1-191 amino acid residues (C191), were expressed as fusion proteins with a 6 × His tag at their N-terminus in E...
May 17, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29777894/endoscopic-transnasal-resection-of-solitary-fibrous-tumor-in-the-optic-canal
#8
Seiei Torazawa, Masahiro Shin, Hirotaka Hasegawa, Ryohei Otani, Keisuke Ueki, Nobuhito Saito
BACKGROUND: Tumors extending into the optic canal can cause progressive visual impairment due to optic nerve compression, and prompt surgical resection is often necessary. When the tumor is located medially in the optic canal, endoscopic transnasal surgery provides a safer, less invasive alternative to trans-cranial approach. CASE DESCRIPTION: We recently encountered a case of small solitary fibrous tumor in the optic canal causing rapid visual deterioration. The radiographic findings of pre-operative imaging studies were compatible with those of meningioma; however, unlike meningioma, bleeding from the tumor was very profuse during the operation...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29777891/surgical-strategy-for-and-anatomical-locations-of-petroapex-and-petroclival-meningiomas-based-on-evaluation-of-the-feeding-artery
#9
Kazuhide Adachi, Mituhiro Hasegawa, Shinichiro Tateyama, Yushi Kawazoe, Yuichi Hirose
OBJECTIVE: The anterior transpetrosal (ATP) approach is the most appropriate approach for petroclival meningiomas, which are typically located from the dorsum sellae to the upper border of the internal acoustic meatus (IAM). Although neurosurgeons can resect over this area if the tumor is detached from the dura, tumors within the indication area for petroclival meningiomas is insufficient for the selection of the ATP approach because it can be difficult to evaluate whether the tumor is attached or only touching the dura...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29776771/association-between-pain-severity-and-clinicohistopathologic-findings-in-the-mandibular-canal-and-inferior-alveolar-nerve-of-patients-with-advanced-mandibular-osteoradionecrosis
#10
Yujiro Hiraoka, Masaya Akashi, Satoshi Wanifuchi, Junya Kusumoto, Manabu Shigeoka, Takumi Hasegawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori
OBJECTIVE: Pain is one of the most problematic symptoms in patients with osteoradionecrosis of the jaws. This study investigated the associations between pain severity and morphologic alterations of the mandibular canal and inferior alveolar nerve, in respective computerized tomography images and resected specimens of mandibular osteoradionecrosis. STUDY DESIGN: We assessed 14 lesions in 13 patients who underwent segmental mandibulectomy for surgical debridement and simultaneous reconstruction with free fibula flap (1 patient exhibited bilateral lesions)...
April 16, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29776704/cerebellar-peduncle-injury-predicts-motor-impairments-in-preterm-infants-a-quantitative-tractography-study-at-term-equivalent-age
#11
Tatsuji Hasegawa, Kei Yamada, Takenori Tozawa, Tomohiro Chiyonobu, Sachiko Tokuda, Akira Nishimura, Hajime Hosoi, Masafumi Morimoto
PURPOSE: Cerebellar injury is well established as an important finding in preterm infants with cerebral palsy (CP). In this study, we investigated associations between injury to the cerebellar peduncles and motor impairments in preterm infants using quantitative tractography at term-equivalent age, which represents an early phase before the onset of motor impairments. METHODS: We studied 64 preterm infants who were born at <33 weeks gestational age. These infants were divided into three groups: CP, Non-CP (defined as infants with periventricular leukomalacia but having normal motor function), and a Normal group...
May 15, 2018: Brain & Development
https://www.readbyqxmd.com/read/29775538/discovery-of-potent-and-centrally-active-6-substituted-5-fluoro-1-3-dihydro-oxazine-%C3%AE-secretase-bace1-inhibitors-via-active-conformation-stabilization
#12
Kenji Nakahara, Kouki Fuchino, Kazuo Komano, Naoya Asada, Genta Tadano, Tsuyoshi Hasegawa, Takahiko Yamamoto, Yusuke Sako, Masayoshi Ogawa, Chie Unemura, Motoko Hosono, Hisanori Ito, Gaku Sakaguchi, Shigeru Ando, Shuichi Ohnishi, Yasuto Kido, Tamio Fukushima, Deborah Dhuyvetter, Herman Borghys, Harrie J M Gijsen, Yoshinori Yamano, Yasuyoshi Iso, Ken-Ichi Kusakabe
β-Secretase (BACE1) has an essential role in the production of amyloid β peptides that accumulate in patients with Alzheimer's disease (AD). Thus, inhibition of BACE1 is considered to be a disease-modifying approach for the treatment of AD. Our hit-to-lead efforts led to a cellular potent 1,3-dihydro-oxazine 6, which however inhibited hERG and showed high P-gp efflux. The close analog of 5-fluoro-oxazine 8 reduced P-gp efflux; further introduction of electron withdrawing groups at the 6-position improved potency and also mitigated P-gp efflux and hERG inhibition...
May 18, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29774429/the-utility-of-superb-microvascular-imaging-for-the-detection-of-deep-vein-thrombosis
#13
Yuta Hagiwara, Rie Sasaki, Takahiro Shimizu, Kaima Soga, Chihiro Hatada, Motoki Miyauchi, Takanori Okamura, Masaru Sakurai, Hisanao Akiyama, Yasuhiro Hasegawa
Superb microvascular imaging (SMI) reduces motion artifacts significantly and allows visualization of low-velocity blood flow in vessels; thus, thrombi are clearly demonstrated compared to conventional B-mode and color Doppler imaging. Ultrasonographic images of the lower extremities of a 69-year-old woman with acute ischemic stroke complicated with deep vein thrombosis (DVT) are presented. Because SMI allows visualization of low-velocity blood flow, echo contrast between the thrombus and the surrounding flow makes it possible to clearly visualize the thrombus...
May 17, 2018: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29773913/auxin-decreases-chromatin-accessibility-through-the-tir1-afbs-auxin-signaling-pathway-in-proliferative-cells
#14
Junko Hasegawa, Takuya Sakamoto, Satoru Fujimoto, Tomoe Yamashita, Takamasa Suzuki, Sachihiro Matsunaga
Chromatin accessibility is closely associated with chromatin functions such as gene expression, DNA replication, and maintenance of DNA integrity. However, the relationship between chromatin accessibility and plant hormone signaling has remained elusive. Here, based on the correlation between chromatin accessibility and DNA damage, we used the sensitivity to DNA double strand breaks (DSBs) as an indicator of chromatin accessibility and demonstrated that auxin regulates chromatin accessibility through the TIR1/AFBs signaling pathway in proliferative cells...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773294/gastroesophageal-reflux-symptoms-and-nasal-symptoms-affect-the-severity-of-bronchitis-symptoms-in-patients-with-chronic-obstructive-pulmonary-disease
#15
Koichi Hasegawa, Susumu Sato, Kazuya Tanimura, Yoshinori Fuseya, Kiyoshi Uemasu, Yoko Hamakawa, Atsuyasu Sato, Michiaki Mishima, Shigeo Muro, Toyohiro Hirai
BACKGROUND: Cough and sputum production (symptoms of bronchitis) are common in chronic obstructive pulmonary disease (COPD). Extrapulmonary comorbidities, such as gastroesophageal reflux disease (GERD) and post-nasal drip, also cause bronchitis symptoms. The impact of extrapulmonary comorbidities on the severity of bronchitis symptoms in COPD is unknown. The aim of this study was to quantify bronchitis symptoms and assess the impact of GERD and nasal symptoms on the severity of bronchitis symptoms in COPD...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29772363/a-comprehensive-study-of-symptomatic-late-radiation-induced-complications-after-radiosurgery-for-brain-arteriovenous-malformation-incidence-risk-factors-and-clinical-outcomes
#16
Hirotaka Hasegawa, Shunya Hanakita, Masahiro Shin, Takehiro Sugiyama, Mariko Kawashima, Wataru Takahashi, Masaaki Shojima, Osamu Ishikawa, Hirofumi Nakatomi, Nobuhito Saito
OBJECT: Stereotactic radiosurgery (SRS) is widely used to treat brain arteriovenous malformation (AVM); however, detailed information on late radiation-induced complications (LRICs) is scarce. The goal of the present study was to characterize the incidence, risk factors, and clinical outcomes of LRICs based on our long-term follow-up data. METHODS: The outcomes of consecutive patients who underwent SRS for AVMs at our institution in 1990-2010 were analyzed. Cyst formation/encapsulated hematoma (CF/EH) and radiation-induced tumor (RIT) were defined as LRICs...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29770831/a-highly-luminescent-eu-iii-complex-based-on-an-electronically-isolated-aromatic-ring-system-with-ultralong-lifetime
#17
Yuichi Kitagawa, Fumiya Suzue, Takayuki Nakanishi, Koji Fushimi, Yasuchika Hasegawa
A luminescent Eu(iii) complex with a large electronically isolated aromatic ring system, Eu(hfa)3(DPPTO)2 (where hfa denotes hexafluoroacetylacetonate and DPPTO denotes 2-diphenylphosphoryltriphenylene), is reported. The light-harvesting efficiency of the Eu(iii) complex was assessed from electronic absorption spectra. Luminescence properties were evaluated from luminescence spectra, excitation spectra, luminescence quantum yields, and luminescence lifetimes. A remarkably brilliant luminescence was observed because of the strong light absorption and the high luminescence quantum yield of the Eu(iii) complex...
May 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29770777/shubnikov-de-haas-oscillations-in-i-p-i-and-i-n-i-type-topological-insulator-bi-sub-x-sub-sb-sub-1-x-sub-sub-2-sub-te-sub-3-sub
#18
Ryota Akiyama, Kazuki Sumida, Satoru Ichinokura, Ryosuke Nakanishi, Akio Kimura, Konstantin A Kokh, Oleg Tereshchenko, Shuji Hasegawa
We show Shubnikov-de Haas (SdH) oscillations in topological insulator (Bi&lt;sub&gt;x&lt;/sub&gt;Sb&lt;sub&gt;1-x&lt;/sub&gt;)&lt;sub&gt;2&lt;/sub&gt;Te&lt;sub&gt;3&lt;/sub&gt; flakes whose carrier types are &lt;i&gt;p&lt;/i&gt;-type (&lt;i&gt;x&lt;/i&gt; = 0.29, 0.34) and &lt;i&gt;n&lt;/i&gt;-type (&lt;i&gt;x&lt;/i&gt; = 0.42). The physical properties such as the Berry phase, carrier mobility, and scattering time significantly changed by tuning the Fermi-level position with the concentration &lt;i&gt;x&lt;/i&gt;...
May 17, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29770370/alkyl-chain-elongation-and-acyl-group-effects-in-a-series-of-eu-tb-complexes-with-hexadentate-%C3%AF-electronic-skeletons-and-their-enhanced-luminescence-in-solutions
#19
Shuhei Ogata, Naoto Goto, Shoya Sakurai, Ayumi Ishii, Miho Hatanaka, Koushi Yoshihara, Ryota Tanabe, Kyosuke Kayano, Ryo Magaribuchi, Kenta Goto, Miki Hasegawa
Five Eu complexes with long alkyl chain groups, abbreviated as EuLCx ("x" indicates the number of methylene groups: x = 8, 12, 14, 18, and 22), were synthesized to evaluate their structural and luminescence properties in chloroform. The mother helicate Eu complex, EuL, which has two bipyridine moieties bridged by an ethylenediamine, has been previously reported. A reduced form in which the azomethine groups of L also coordinated to the Eu ion, EuLH, was newly prepared. EuLH also adopts a helicate molecular structure based on single crystal X-ray structural analysis...
May 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29770217/analysis-of-adverse-events-of-renal-impairment-related-to-platinum-based-compounds-using-the-japanese-adverse-drug-event-report-database
#20
Misa Naganuma, Yumi Motooka, Sayaka Sasaoka, Haruna Hatahira, Shiori Hasegawa, Akiho Fukuda, Satoshi Nakao, Kazuyo Shimada, Koseki Hirade, Takayuki Mori, Tomoaki Yoshimura, Takeshi Kato, Mitsuhiro Nakamura
Objectives: Platinum compounds cause several adverse events, such as nephrotoxicity, gastrointestinal toxicity, myelosuppression, ototoxicity, and neurotoxicity. We evaluated the incidence of renal impairment as adverse events are related to the administration of platinum compounds using the Japanese Adverse Drug Event Report database. Methods: We analyzed adverse events associated with the use of platinum compounds reported from April 2004 to November 2016. The reporting odds ratio at 95% confidence interval was used to detect the signal for each renal impairment incidence...
2018: SAGE Open Medicine
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