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https://www.readbyqxmd.com/read/29913275/rates-and-factors-associated-with-placebo-response-in-trials-of-pharmacotherapies-for-nonalcoholic-steatohepatitis-systematic-review-and-meta-analysis
#1
REVIEW
Ma Ai Thanda Han, Osama Altayar, Shadi Hamdeh, Varun Takyar, Yaron Rotman, Ohad Etzion, Eric Lefebvre, Rifaat Safadi, Vlad Ratziu, Larry J Prokop, Mohammad Hassan Murad, Mazen Noureddin
BACKGROUND & AIMS: Understanding the extent of the placebo effect in randomized controlled trials of studying nonalcoholic steatohepatitis (NASH) is important for optimal trial design, including sample size calculations and treatment endpoint definition. METHODS: We performed a systematic review and meta-analysis of the placebo groups from randomized controlled trials of adults with NASH that provided histological and/or magnetic resonance image-based measurements of intrahepatic triglyceride...
June 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29912058/a-systematic-review-of-the-operational-definitions-for-antipsychotic-response-in-delusional-disorder
#2
Alexandre González-Rodríguez, Francesc Estrada, José A Monreal, Diego Palao, Javier Labad
This review aimed to examine and analyse the definitions used for antipsychotic response in delusional disorder (DD) and to provide a discussion of the methodology used. A systematic review was performed using the PubMed, Scopus and PsycINFO databases (1990-October 2017) according to the PRISMA statement. In addition, reference searches were performed manually through identified studies to obtain other relevant articles. The search terms included 'antipsychotic response', 'antipsychotics', 'treatment response' and 'delusional disorder'...
June 14, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29908360/heterogeneity-in-clinical-endoscopic-and-histologic-outcome-measures-and-placebo-response-rates-in-clinical-trials-of-eosinophilic-esophagitis-a-systematic-review
#3
REVIEW
Christopher Ma, Bram D van Rhijn, Vipul Jairath, Tran M Nguyen, Claire E Parker, Seema S Aceves, Glenn T Furuta, Sandeep K Gupta, David A Katzka, Ekaterina Safroneeva, Alain M Schoepfer, Alex Straumann, Jonathan M Spergel, Rish K Pai, Brian G Feagan, Ikuo Hirano, Evan S Dellon, Albert J Bredenoord
BACKGROUND & AIMS: Agents are being developed for treatment of eosinophilic esophagitis (EoE). However, it is not clear what outcome measures would best determine the efficacy and safety of these agents in clinical trials. We performed a systematic review of outcomes used in randomized placebo-controlled trials of EoE and we estimate the placebo response and rates of remission. METHODS: We searched MEDLINE, Embase, CENTRAL, ClinicalTrials.gov, and the EU Clinical Trials Register from inception through February 20, 2018 for randomized controlled trials of pharmacologic therapies for EoE...
June 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29905778/predictive-biomarkers-for-response-to-egfr-directed-monoclonal-antibodies-for-advanced-squamous-cell-lung-cancer
#4
P D Bonomi, D Gandara, F R Hirsch, K M Kerr, C Obasaju, L Paz-Ares, C Bellomo, J D Bradley, P A Bunn, M Culligan, J R Jett, E S Kim, C J Langer, R B Natale, S Novello, M Pérol, S S Ramalingam, M Reck, C H Reynolds, E F Smit, M A Socinski, D R Spigel, J F Vansteenkiste, H Wakelee, N Thatcher
Background: Upregulated expression and aberrant activation of the epidermal growth-factor receptor (EGFR) are found in lung cancer, making EGFR a relevant target for non-small-cell lung cancer (NSCLC). Treatment with anti-EGFR monoclonal antibodies (mAbs) is associated with modest improvement in overall survival in patients with squamous cell lung cancer (SqCLC) who have a significant unmet need for effective treatment options. While there is evidence that using EGFR gene copy number, EGFR mutation, and EGFR protein expression as biomarkers can help select patients who respond to treatment, it is important to consider biomarkers for response in patients treated with combination therapies that include EGFR mAbs...
June 14, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29901224/pathway-focused-gene-expression-profiles-and-immunohistochemistry-detection-identify-contrasting-association-of-caspase-3-casp3-expression-with-prognosis-in-pediatric-classical-hodgkin-lymphoma
#5
Gabriela Vera-Lozada, Priscilla Segges, Claudio Gustavo Stefanoff, Mário Henrique M Barros, Gerald Niedobitek, Rocio Hassan
The search for clinically relevant molecular markers in classical Hodgkin lymphoma (cHL) is hampered by the histopathological complexity of the disease, resulting from the admixture of a small number of neoplastic Hodgkin and Reed-Sternberg (H-RS) cells with an abundant and heterogeneous microenvironment. In this study, we evaluated gene expression profiles of 11 selected genes previously proposed as a molecular score for adult cHL, aiming to validate its application in the pediatric setting. Assays were performed by RT-qPCR from formalin-fixed paraffin-embedded (FFPE) lymph nodes in 80 patients with cHL...
June 14, 2018: Hematological Oncology
https://www.readbyqxmd.com/read/29897484/ildgendb-integrated-genetic-knowledge-resource-for-interstitial-lung-diseases-ilds
#6
Smriti Mishra, Mohammad I Shah, Malay Sarkar, Nimisha Asati, Chittaranjan Rout
Interstitial lung diseases (ILDs) are a diverse group of ∼200 acute and chronic pulmonary disorders that are characterized by variable amounts of inflammation, fibrosis and architectural distortion with substantial morbidity and mortality. Inaccurate and delayed diagnoses increase the risk, especially in developing countries. Studies have indicated the significant roles of genetic elements in ILDs pathogenesis. Therefore, the first genetic knowledge resource, ILDgenDB, has been developed with an objective to provide ILDs genetic data and their integrated analyses for the better understanding of disease pathogenesis and identification of diagnostics-based biomarkers...
January 1, 2018: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29895273/prevalence-of-acute-stress-disorder-among-road-traffic-accident-survivors-a-meta-analysis
#7
Wenjie Dai, Aizhong Liu, Atipatsa C Kaminga, Jing Deng, Zhiwei Lai, Jianzhou Yang, Shi Wu Wen
BACKGROUND: Road traffic accident (RTA), an unexpected traumatic event, may not only lead to death and serious physical injuries, but also could put survivors at an increased risk for a wide range of psychiatric disorders, particularly acute stress disorder (ASD). Early assessment of trauma-related psychological responses is important because acute trauma responses in the early post-traumatic period are among the robust predictors of long-term mental health problems. However, estimates of the prevalence of ASD among RTA survivors varied considerably across studies...
June 13, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29889859/global-etiology-of-bacterial-meningitis-a-systematic-review-and-meta-analysis
#8
Anouk M Oordt-Speets, Renee Bolijn, Rosa C van Hoorn, Amit Bhavsar, Moe H Kyaw
Bacterial meningitis is a global public health concern, with several responsible etiologic agents that vary by age group and geographical area. The aim of this systematic review and meta-analysis was to assess the etiology of bacterial meningitis in different age groups across global regions. PubMed and EMBASE were systematically searched for English language studies on bacterial meningitis, limited to articles published in the last five years. The methodological quality of the studies was assessed using a customized scoring system...
2018: PloS One
https://www.readbyqxmd.com/read/29888047/usability-evaluation-of-an-unstructured-clinical-document-query-tool-for-researchers
#9
Gretchen Hultman, Reed McEwan, Serguei Pakhomov, Elizabeth Lindemann, Steven Skube, Genevieve B Melton
Natural Language Processing - Patient Information Extraction for Researchers (NLP-PIER) was developed for clinical researchers for self-service Natural Language Processing (NLP) queries with clinical notes. This study was to conduct a user-centered analysis with clinical researchers to gain insight into NLP-PIER's usability and to gain an understanding of the needs of clinical researchers when using an application for searching clinical notes. Clinical researcher participants (n=11) completed tasks using the system's two existing search interfaces and completed a set of surveys and an exit interview...
2018: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/29882342/the-effect-of-pet-therapy-on-the-physiological-and-subjective-stress-response-a-meta-analysis
#10
REVIEW
Natalie Ein, Lingqian Li, Kristin Vickers
Studies have reported that exposure to pet therapy (PT) can reduce physiological and subjective stress and anxiety levels. The aim of this meta-analysis is to examine the efficacy of PT as a method for reducing physiological stress levels (blood pressure and heart rate) and subjective stress and anxiety scores (self-reported stress/anxiety). Further, we examined the effects of sample characteristics and modifications to the PT (different age groups and health status of participants across samples, whether a stressor was present, and individual versus group PT) as potential moderators of the relationship between PT and stress reactivity...
June 8, 2018: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/29878221/quality-indicators-for-responsible-antibiotic-use-in-the-inpatient-setting-a-systematic-review-followed-by-an-international-multidisciplinary-consensus-procedure
#11
Annelie A Monnier, Jeroen Schouten, Marion Le Maréchal, Gianpiero Tebano, Céline Pulcini, Mirjana Stanic Benic, Vera Vlahovic-Palcevski, Romina Milanic, Niels Adriaenssens, Ann Versporten, Benedikt Huttner, Veronica Zanichelli, Marlies E Hulscher, Inge C Gyssens
Background: This study was conducted as part of the Driving Reinvestment in Research and Development and Responsible Antibiotic Use (DRIVE-AB) project and aimed to develop generic quality indicators (QIs) for responsible antibiotic use in the inpatient setting. Methods: A RAND-modified Delphi method was applied. First, QIs were identified by a systematic review. A complementary search was performed on web sites of relevant organizations. Duplicates were removed and disease and patient-specific QIs were combined into generic indicators...
June 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29878216/towards-a-global-definition-of-responsible-antibiotic-use-results-of-an-international-multidisciplinary-consensus-procedure
#12
Annelie A Monnier, Barry I Eisenstein, Marlies E Hulscher, Inge C Gyssens
Background: Conducted as part of the Driving Reinvestment in Research and Development and Responsible Antibiotic Use (DRIVE-AB) project, this study aimed to identify key elements for a global definition of responsible antibiotic use based on diverse stakeholder input. Methods: A three-step RAND-modified Delphi method was applied. First, a systematic review of antibiotic stewardship literature and relevant organization web sites identified definitions and synonyms of responsible use...
June 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29869903/immunophenotypic-variations-in-mantle-cell-lymphoma-and-their-impact-on-clinical-behavior-and-outcome
#13
Barina Aqil, Grace Triska, John Frater, Anjum Hassan, Marianna B Ruzinova, Amanda Cashen, Yvette Reese, Friederike Kreisel
Context Immunophenotypic variations in mantle cell lymphoma (MCL) from the classic CD5+ /CD10- /CD23- /FMC-7+ immunophenotype have been reported in the literature, but correlation with clinical behavior and outcome has not been fully studied. Objective To investigate clinicopathologic and prognostic differences between immunophenotypically aberrant MCL and immunophenotypically typical MCL. Design We evaluated differences in clinical presentation, laboratory parameters, prognostic indices, response to initial treatment, and progression-free and overall survival between patients with aberrant MCL and patients with immunophenotypically typical MCL...
June 5, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29864120/language-outcome-related-to-brain-structures-in-school-aged-preterm-children-a-systematic-review
#14
Lottie W Stipdonk, Marie-Christine J P Franken, Jeroen Dudink
Preterm children often have language problems. This atypical language development is probably due to atypical brain development. We conducted a systematic review to provide an overview of the extensive and diverse scientific literature on the relations between language outcome and underlying brain structures in school-aged preterm-born children. Embase, Medline Ovid, Web of Science, Cochrane central and Google scholar were searched for relevant studies. Inclusion criteria were: cases are school-aged preterm children; structural MRI (T1- and T2-weighted sequences) or DTI used in combination with a neurocognitive language test; publication in an English-language peer-reviewed journal...
2018: PloS One
https://www.readbyqxmd.com/read/29858846/5-%C3%AE-reductase-type-2-deficiency-is-there-a-genotype-phenotype-correlation-a-review
#15
REVIEW
Andrea Avendaño, Irene Paradisi, Francisco Cammarata-Scalisi, Michele Callea
5-α-Reductase type 2 enzyme catalyzes the conversion of testosterone into dihydrotestosterone, a potent androgen responsible for male sexual development during the fetal period and later during puberty. Its deficiency causes an autosomal recessive disorder of sex development characterized by a wide range of under-virilization of external genitalia in patients with a 46,XY karyotype. Mutations in the SRD5A2 gene cause 5-α-Reductase deficiency; although it is an infrequent disorder, it has been reported worldwide, with mutational heterogeneity...
April 20, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29849461/comparative-efficacy-and-safety-of-crocus-sativus-l-for-treating-mild-to-moderate-major-depressive-disorder-in-adults-a-meta-analysis-of-randomized-controlled-trials
#16
Xiangying Yang, Xiaolu Chen, Yixiao Fu, Qinghua Luo, Lian Du, Haitang Qiu, Tian Qiu, Li Zhang, Huaqing Meng
Purpose: To investigate the efficacy and safety of saffron in the treatment of major depressive disorder (MDD) in comparison to placebo and synthetic antidepressants. Patients and methods: We conducted a systematic search in several electronic databases as well as manual search in bibliographies of relevant studies. We included randomized controlled trials that investigated the efficacy and safety of saffron for treating MDD in adults in comparison to either placebo or synthetic antidepressants...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29845614/risk-factors-for-intensive-care-unit-acquired-weakness-a-systematic-review-and-meta-analysis
#17
REVIEW
Tao Yang, Zhiqiang Li, Li Jiang, Yinhua Wang, Xiuming Xi
Intensive care unit-acquired weakness (ICUAW) occurs frequently in the context of critical illness without alternative plausible cause and specific treatment options, and it is important to identify and summarize the independent risk factors for ICUAW. PubMed, Embase, Central, China Biological Medicine, China National Knowledge Infrastructure, VIP and Wanfang databases were searched from database inception until 10 July 2017. Prospective cohort studies on adult ICU patients who were diagnosed with ICUAW using either clinical or electrophysiological criteria were selected...
May 29, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29845119/applying-metacognition-through-patient-encounters-and-illness-scripts-to-create-a-conceptual-framework-for-basic-science-integration-storage-and-retrieval
#18
Eileen F Hennrikus, Michael P Skolka, Nicholas Hennrikus
Problem: Medical school curriculum continues to search for methods to develop a conceptual educational framework that promotes the storage, retrieval, transfer, and application of basic science to the human experience. To achieve this goal, we propose a metacognitive approach that integrates basic science with the humanistic and health system aspects of medical education. Intervention: During the week, via problem-based learning and lectures, first-year medical students were taught the basic science underlying a disease...
January 2018: Journal of Medical Education and Curricular Development
https://www.readbyqxmd.com/read/29802811/mirtazapine-adjunct-for-people-with-schizophrenia
#19
REVIEW
Luke A Perry, Dhruvesh Ramson, Suzanne Stricklin
BACKGROUND: Many individuals who have a diagnosis of schizophrenia experience a range of distressing and debilitating symptoms. These can include positive symptoms (such as delusions, hallucinations, disorganised speech), cognitive symptoms (such as trouble focusing or paying attention or using information to make decisions), and negative symptoms (such as diminished emotional expression, avolition, alogia, and anhedonia). Antipsychotic drugs are often only partially effective, particularly in treating negative symptoms, indicating the need for additional treatment...
May 26, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29801505/reported-use-of-evidence-in-clinical-practice-a-survey-of-rehabilitation-practices-in-norway
#20
Jennifer L Moore, Svein Friis, Ian D Graham, Elisabeth Troøyen Gundersen, Jan E Nordvik
BACKGROUND: The South Eastern Health Region in Norway serves approximately 2.8 million people, which is more than half of Norway's population. Physical medicine and rehabilitation services are provided by 9 public hospital trusts and 30 private rehabilitation facilities. The purposes of this study were to conduct a psychometric analysis of the EBP Implementation Scale (EBPIS) and describe rehabilitation clinicians' self-reported 1) use of evidence-based practices (EBPs), 2) use of EBPs across hospitals, and 3) determine factors associated with use of EBPs in the South Eastern Health Region in Norway...
May 25, 2018: BMC Health Services Research
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