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https://www.readbyqxmd.com/read/29218903/coalitional-game-theory-as-a-promising-approach-to-identify-candidate-autism-genes
#1
Anika Gupta, Min Woo Sun, Kelley Marie Paskov, Nate Tyler Stockham, Jae-Yoon Jung, Dennis Paul Wall
Despite mounting evidence for the strong role of genetics in the phenotypic manifestation of Autism Spectrum Disorder (ASD), the specific genes responsible for the variable forms of ASD remain undefined. ASD may be best explained by a combinatorial genetic model with varying epistatic interactions across many small effect mutations. Coalitional or cooperative game theory is a technique that studies the combined effects of groups of players, known as coalitions, seeking to identify players who tend to improve the performance--the relationship to a specific disease phenotype--of any coalition they join...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29213344/psychotherapy-for-major-depressive-disorder-and-generalized-anxiety-disorder-a-health-technology-assessment
#2
(no author information available yet)
Background: Major depressive disorder and generalized anxiety disorder are among the most commonly diagnosed mental illnesses in Canada; both are associated with a high societal and economic burden. Treatment for major depressive disorder and generalized anxiety disorder consists of pharmacological and psychological interventions. Three commonly used psychological interventions are cognitive behavioural therapy (CBT), interpersonal therapy, and supportive therapy. The objectives of this report were to assess the effectiveness and safety of these types of therapy for the treatment of adults with major depressive disorder and/or generalized anxiety disorder, to assess the cost-effectiveness of structured psychotherapy (CBT or interpersonal therapy), to calculate the budget impact of publicly funding structured psychotherapy, and to gain a greater understanding of the experiences of people with major depressive disorder and/or generalized anxiety disorder...
2017: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/29197180/acupuncture-for-neuropathic-pain-in-adults
#3
REVIEW
Zi Yong Ju, Ke Wang, Hua Shun Cui, Yibo Yao, Shi Min Liu, Jia Zhou, Tong Yu Chen, Jun Xia
BACKGROUND: Neuropathic pain may be caused by nerve damage, and is often followed by changes to the central nervous system. Uncertainty remains regarding the effectiveness and safety of acupuncture treatments for neuropathic pain, despite a number of clinical trials being undertaken. OBJECTIVES: To assess the analgesic efficacy and adverse events of acupuncture treatments for chronic neuropathic pain in adults. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, four Chinese databases, ClinicalTrials...
December 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29189670/psychological-and-psychiatric-outcomes-following-picu-admission-a-systematic-review-of-cohort-studies
#4
Luís Carlos Lopes-Júnior, Maria Antonia Dos Reis de Paula Rosa, Regina Aparecida Garcia de Lima
OBJECTIVE: Admissions to PICU places pediatric patients at increased risk of persistent psychological and psychiatric morbidity. This systematic review aimed to summarize and critically examine literature regarding psychological and psychiatric outcomes of pediatric patients following PICU admission. DATA SOURCES: MEDLINE, Web of Science, Cochrane Library, Science Direct, PsycInfo, CINAHL, LILACS, and SciELO were searched up to May 2016. STUDY SELECTION: Cohort studies about psychological and psychiatric outcomes of pediatric patients following PICU admission; full-text records published in English, Spanish, or Portuguese in peer-reviewed journals from 2000 to 2015 were included...
November 20, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29189148/identification-of-novel-ligands-for-therapeutic-lipopeptides-daptomycin-surfactin-and-polymyxin
#5
Satya Eswari Jujjavarapu, Swasti Dhagat, Vinay Kurrey
Due to increase in antibiotic-resistance among pathogens, there is a need for potent and safe drugs. An alternative to antibiotics is lipopeptides which are produced as a secondary metabolite by many microorganisms. They exhibit broad-spectrum activities against pathogens along with anti-cancer properties. Among various lipopeptides produced by microorganisms, daptomycin, surfactin, and polymyxin have gained popularity as medicines but their mechanism of action is not described properly. In silico drug design of these lipopeptides becomes a challenge due to their complex structures...
November 29, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29188733/investigational-drugs-in-clinical-trials-for-hidradenitis-suppurativa
#6
Peter Theut Riis, Linnea R Thorlacius, Gregor B Jemec
Hidradenitis suppurativa is a chronic skin disease with a significant unmet need for treatment options. Randomized controlled trials are few and only a single drug (adalimumab) has Hidradenitis as a registered indication. Areas covered: The clinicaltrials.gov and the EudraCT clinical trials register for reported trials on Hidradenitis Suppurativa was searched on the 22-06-2017. Trials for upcoming new drugs for HS are reported focusing on drugs in phase I and II trials. Expert opinion: Currently, MABp1, Secukinumab, CJM112, Apremilast and IFX-1 are being investigated in Phase I and II trials and offer theoretical and promising new treatment options...
November 30, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29185258/corticosteroids-for-chronic-inflammatory-demyelinating-polyradiculoneuropathy
#7
REVIEW
Richard Ac Hughes, Man Mohan Mehndiratta, Yusuf A Rajabally
BACKGROUND: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a progressive or relapsing and remitting paralysing illness, probably due to an autoimmune response, which should benefit from corticosteroid treatment. Non-randomised studies suggest that corticosteroids are beneficial. Two commonly used corticosteroids are prednisone and prednisolone. Both are usually given as oral tablets. Prednisone is converted into prednisolone in the liver so that the effect of the two drugs is usually the same...
November 29, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29184524/a-qualitative-approach-on-motives-and-aspects-of-risks-in-freeriding
#8
Anika Frühauf, Will A S Hardy, Daniel Pfoestl, Franz-Georg Hoellen, Martin Kopp
Recent research has shown that there are multiple motives for participation in high-risk sport; however these results have come from studies that consider a number of different sports. Therefore, the aim of the present study was to better understand the motives and risk-related aspects of freeriding, using a qualitative approach. Semi-structured interviews were conducted with 40 professional and semi-professional freeride skiers and snowboarders. All freeriders were highly experienced, of different age (19-44 years; 27...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29184194/interventions-for-management-of-post-stroke-depression-a-bayesian-network-meta-analysis-of-23-randomized-controlled-trials
#9
Linghui Deng, Xuejun Sun, Shi Qiu, Yao Xiong, Yuxiao Li, Lu Wang, Qiang Wei, Deren Wang, Ming Liu
Post-stroke depression (PSD) is an important complication of stroke, leading to increased disability and mortality. Given that there is no consensus on which treatment is optimal for PSD, we aimed to evaluate the relative efficacies of available pharmacological and non-pharmacological interventions. We conducted a network meta-analysis to incorporate evidence from relevant trials and provide direct and indirect comparisons. We searched PubMed, Cochrane Library Central Register of Controlled Trials, and Embase until November 1, 2016 for randomized controlled trials involving different pharmacological and non-pharmacological PSD treatment interventions...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29178149/measuring-activities-and-participation-in-persons-with-haemophilia-a-systematic-review-of-commonly-used-instruments
#10
REVIEW
M A Timmer, S C Gouw, B M Feldman, A Zwagemaker, P de Kleijn, M F Pisters, R E G Schutgens, V Blanchette, A Srivastava, J A David, K Fischer, J van der Net
INTRODUCTION: Monitoring clinical outcome in persons with haemophilia (PWH) is essential in order to provide optimal treatment for individual patients and compare effectiveness of treatment strategies. Experience with measurement of activities and participation in haemophilia is limited and consensus on preferred tools is lacking. AIM: The aim of this study was to give a comprehensive overview of the measurement properties of a selection of commonly used tools developed to assess activities and participation in PWH...
November 27, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29171925/clinical-and-photobiological-response-in-eight-patients-with-solar-urticaria-under-treatment-with-omalizumab-and-review-of-the-literature
#11
D Morgado-Carrasco, X Fustà-Novell, S Podlipnik, A Combalia, P Aguilera
BACKGROUND: Solar urticaria (SU) is a rare photodermatosis. Treatment is challenging and outcomes are often disappointing. Omalizumab is an anti-IgE, currently approved for treatment of chronic spontaneous urticaria. We sought to evaluate therapy with omalizumab in refractory SU and describe predictive factors for response. MATERIALS/METHODS: Patients with refractory SU under treatment with omalizumab were included in this study. Clinical outcome was evaluated using the Urticaria Activity score 7 (UAS7), Dermatology Life Quality Index (DLQI) and Pruritus Visual Analogue scale (VAS)...
November 24, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29170503/mutational-and-putative-neoantigen-load-predict-clinical-benefit-of-adoptive-t-cell-therapy-in-melanoma
#12
Martin Lauss, Marco Donia, Katja Harbst, Rikke Andersen, Shamik Mitra, Frida Rosengren, Maryem Salim, Johan Vallon-Christersson, Therese Törngren, Anders Kvist, Markus Ringnér, Inge Marie Svane, Göran Jönsson
Adoptive T-cell therapy (ACT) is a highly intensive immunotherapy regime that has yielded remarkable response rates and many durable responses in clinical trials in melanoma; however, 50-60% of the patients have no clinical benefit. Here, we searched for predictive biomarkers to ACT in melanoma. Whole exome- and transcriptome sequencing and neoantigen prediction were applied to pre-treatment samples from 27 patients recruited to a clinical phase I/II trial of ACT in stage IV melanoma. All patients had previously progressed on other immunotherapies...
November 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/29169957/operative-versus-nonoperative-treatment-for-the-management-of-full-thickness-rotator-cuff-tears-a-systematic-review-and-meta-analysis
#13
Christine C Piper, Alice J Hughes, Yan Ma, Haijun Wang, Andrew S Neviaser
BACKGROUND: Rotator cuff disease is the most common pathology of the shoulder, responsible for approximately 70% of clinic visits for shoulder pain. However, no consensus exists on the optimal treatment. The aim of this study was to analyze level I and II research comparing operative versus nonoperative management of full-thickness rotator cuff tears. METHODS: A literature search was performed, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, to identify level I and II studies comparing operative versus nonoperative treatment of rotator cuff tears...
November 21, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29168289/cannabinoids-for-nausea-and-vomiting-related-to-chemotherapy-overview-of-systematic-reviews
#14
REVIEW
Victor Schussel, Lucas Kenzo, Andreia Santos, Júlia Bueno, Ellen Yoshimura, Carolina de Oliveira Cruz Latorraca, Daniela Vianna Pachito, Rachel Riera
Nausea and vomiting are common and distressing adverse events of chemotherapy. This review focuses on the findings and quality of systematic reviews (SRs) of cannabinoids for chemotherapy-induced nausea and vomiting (CINV). Review of SRs, a systematic literature search, was conducted in several electronic databases and included SRs evaluating cannabinoids for CINV in cancer patients. Methodological quality and quality of reporting were evaluated by AMSTAR and PRISMA, respectively. Initial search retrieved 2,206 records, and 5 SRs were included...
November 23, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29166260/the-development-and-content-validation-of-a-multidisciplinary-evidence-based-wound-infection-prevention-and-treatment-guideline
#15
Sammy A Zakhary, Chris Davey, Rebecca Bari, Jordan Bean, Tyler Reber, Kathy Gallagher, Kara Couch, Jennifer Hurlow, Karen Laforet, Corrine McIssac, Karen Napier, Diana Vilar-Compte, Emily Zakhary, Michel Hermans, Laura Bolton
Acute and chronic wound infections create clinical, economic, and patient-centered challenges best met by multidisciplinary wound care teams providing consistent, valid, clinically relevant, safe, evidence-based management across settings. To develop an evidence-based wound infection guideline, PubMed, Cochrane Library, and Cumulative Index to Nursing and Allied Health Literature databases were searched from inception through August 1, 2017 using the terms (or synonyms) wound infection and risk factor, significant, diagnosis, prevention, treatment, or surveillance...
November 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/29159860/assessment-of-sedation-level-prior-to-neonatal-intubation-a%C3%A2-systematic-review
#16
REVIEW
Ellen H M de Kort, Nienke M Halbmeijer, Irwin K M Reiss, Sinno H P Simons
BACKGROUND: Adequate premedication before neonatal endotracheal intubation reduces pain, stress, and adverse physiological responses, diminishes duration and number of attempts at intubation, and prevents traumatic airway injury. Therefore, intubation should not be started until an adequate level of sedation is reached. It is not clear how this should be measured in the clinical situation. OBJECTIVES: The aim of this study is to provide a systematic review of the usability and validity of scoring systems or other objective parameters to evaluate the level of sedation before intubation in neonates...
November 20, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29159602/competitive-advantage-of-mba-for-physician-executives-a-systematic-literature-review
#17
REVIEW
Anthony D Turner, Stanislaw P Stawicki, Weidun Alan Guo
In response to systemic challenges facing the US healthcare system, many medical students, residents and practicing physicians are pursuing a Master in Business Administration (MBA) degree. The value of such proposition remains poorly defined. The aim of this review is to analyze current literature pertaining to the added value of MBA training for physician executives (PEs). We hypothesized that physicians who supplement their clinical expertise with business education gain a significant competitive advantage...
November 20, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29157311/peripheral-and-local-predictive-immune-signatures-identified-in-a-phase-ii-trial-of-ipilimumab-with-carboplatin-paclitaxel-in-unresectable-stage-iii-or-stage-iv-melanoma
#18
Rahima Jamal, Réjean Lapointe, Eftihia Cocolakis, Paméla Thébault, Shirin Kazemi, Jennifer E Friedmann, Jeanne Dionne, Jean-François Cailhier, Karl Bélanger, Jean-Pierre Ayoub, Huy Le, Caroline Lambert, Jida El-Hajjar, Léon C van Kempen, Alan Spatz, Wilson H Miller
BACKGROUND: Checkpoint blockade with ipilimumab provides long-term survival to a significant proportion of patients with metastatic melanoma. New approaches to increase survival and to predict which patients will benefit from treatment are needed. This phase II trial combined ipilimumab with carboplatin/paclitaxel (CP) to assess its safety, efficacy, and to search for peripheral and tumor-based predictive biomarkers. METHODS: Thirty patients with untreated unresectable/metastatic melanoma were treated with ipilimumab and CP...
November 21, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29149828/vortioxetine-treatment-for-anxiety-disorder-a-meta-analysis-study
#19
Anne Yee, Chong Guan Ng, Loh Huai Seng
BACKGROUND: Vortioxetine is a multimodal antidepressant that has been developed for the treatment of major depressive and anxiety disorders. The aim of this review is to quantitatively synthesize all data of the efficacy, safety and tolerability of Vortioxetine in treating anxiety disorder. METHOD: Terms of "Vortioxetine" OR "LuAA21004" AND "anxiety" OR "fear" OR "panic" OR "phobia" were searched. A total of two phase II and five phase III clinical trials were found...
November 17, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29146474/a-systematic-review-and-meta-analysis-of-deep-brain-stimulation-in-treatment-resistant-depression
#20
Chanjuan Zhou, Hanping Zhang, Yinhua Qin, Tian Tian, Bing Xu, Jianjun Chen, Xinyu Zhou, Li Zeng, Liang Fang, Xunzhong Qi, Bin Lian, Haiyang Wang, Zicheng Hu, Peng Xie
BACKGROUND: Deep brain stimulation (DBS) has been applied in treatment-resistant depression (TRD) as a putative intervention targeting different brain regions. However, the antidepressant effects of DBS for TRD in recent clinical trials remain controversial. METHODS: We searched Scopus, EMBASE, the Cochrane Library, PubMed, and PsycINFO for all published studies investigating the efficacy of DBS in TRD up to Feb 2017. Hamilton depression rating scale (HDRS) scores and Montgomery-Asberg depression rating scale (MARDS) scores were compared between baseline levels and those after DBS using the standardized mean difference (SMD) with 95% confidence intervals (CIs)...
November 13, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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