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https://www.readbyqxmd.com/read/28655060/biomarkers-and-surrogate-endpoints-in-uveitis-the-impact-of-quantitative-imaging
#1
Alastair K Denniston, Pearse A Keane, Sunil K Srivastava
Purpose: Uveitis is a major cause of sight loss across the world. The reliable assessment of intraocular inflammation in uveitis ('disease activity') is essential in order to score disease severity and response to treatment. In this review, we describe how 'quantitative imaging', the approach of using automated analysis and measurement algorithms across both standard and emerging imaging modalities, can develop objective instrument-based measures of disease activity. Methods: This is a narrative review based on searches of the current world literature using terms related to quantitative imaging techniques in uveitis, supplemented by clinical trial registry data, and expert knowledge of surrogate endpoints and outcome measures in ophthalmology...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28640288/prognostic-factors-for-transplant-free-survival-and-validation-of-prognostic-models-in-chinese-patients-with-primary-biliary-cholangitis-receiving-ursodeoxycholic-acid
#2
Ka-Shing Cheung, Wai-Kay Seto, James Fung, Ching-Lung Lai, Man-Fung Yuen
OBJECTIVES: We aimed to validate the prognostic models for primary biliary cholangitis (PBC) in Chinese patients receiving ursodeoxycholic acid (UCDA), and to compare their performances in predicting the long-term survival. METHODS: Chinese patients with PBC from a tertiary center were identified via electronic search of hospital medical registry. Risk factors associated with adverse events (liver transplantation or death from liver-related causes including hepatocellular carcinoma (HCC) and liver decompensation) were determined...
June 22, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28631681/-the-evaluation-of-the-quality-of-life-in-a-healthy-population-with-the-use-of-the-comq-12-questionnaire
#3
S Ya Kosyakov, Yu V Minavnina, K N Bgantseva, A L Dryupin
The COMQ-12 questionnaire has been elaborated to evaluate the deterioration in the quality of life of the subjects suffering from chronic suppurative otitis media (CSOM) based on the reports of the patients themselves. This questionnaire is of special interest in that it allows to register the complaints of the patients stated by them in the order of priority beginning from those that are responsible for the most pronounced manifestations of the impairment in the quality of life. It, in turn, helps the medical practitioner to rationally organize the treatment of a concrete patient taking into consideration his or her individual expectations...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28630049/comparison-of-electroacupuncture-and-medical-treatment-for-functional-constipation-a-systematic-review-and-meta-analysis
#4
Sheng-Li Zhou, Xiu-Lai Zhang, Jing-Hua Wang
OBJECTIVES: To assess the effectiveness of electroacupuncture (EA) relative to conventional medication in functional constipation (FC). DESIGN: Systematic review and meta-analysis SETTING: To be included, studies needed to: (1) have been randomised controlled trials; (2) have recruited adult patients diagnosed with FC according to the Rome II/III criteria or the American Gastroenterological Association guideline for chronic FC; and (3) have randomised patients to be treated with EA or anti-constipation medication...
June 19, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/28615409/outcome-tools-for-diabetes-specific-quality-of-life-study-performed-in-a-private-family-practice-clinic
#5
Rajesh Nair, Paul Kachan
OBJECTIVE: To critically review and evaluate the psychometric properties and practical considerations of administering generic and diabetes-specific quality-of-life (QoL) tools in the clinical environment and provide recommendations. DATA SOURCES AND TOOL SELECTION: A MEDLINE search was carried out from January 1950 to August 2015 using the MeSH terms diabetes, quality of life, and questionnaires. Four generic and 4 diabetes-specific tools were selected based on the frequency of their use and the existence of published evidence of strong psychometric properties in patients with diabetes (either type 1 or 2)...
June 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28613395/clozapine-dose-for-schizophrenia
#6
REVIEW
Selvizhi Subramanian, Birgit A Völlm, Nick Huband
BACKGROUND: Schizophrenia and related disorders such as schizophreniform and schizoaffective disorder are serious mental illnesses characterised by profound disruptions in thinking and speech, emotional processes, behaviour and sense of self. Clozapine is useful in the treatment of schizophrenia and related disorders, particularly when other antipsychotic medications have failed. It improves positive symptoms (such as delusions and hallucinations) and negative symptoms (such as withdrawal and poverty of speech)...
June 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28605312/examination-of-response-shift-after-rehabilitation-for-orthopedic-conditions-a-systematic-review
#7
Cameron J Powden, Matthew C Hoch, Johanna M Hoch
CONTEXT: There is an increased emphasis on the need to capture and incorporate self-reported function to make clinical decisions when providing patient-centered care. Response shift, or a change in an individual's self-evaluation of a construct, may affect the accurate assessment of change in self-reported function throughout the course of rehabilitation. A systematic review of this phenomenon may provide valuable information regarding the accuracy of self-reported function. OBJECTIVES: To systematically locate and synthesize the existing evidence regarding response shift during care for various orthopedic conditions...
June 12, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28598762/efficacy-of-arginine-enriched-enteral-formulas-for-the-healing-of-pressure-ulcers-a-systematic-review
#8
P Liu, W-Q Shen, H-L Chen
OBJECTIVE: Arginine improves healing and modulates inflammation and the immune response. This systematic review aimed to assess the effect of arginine-enriched enteral formulas in pressure ulcer (PU) healing. METHOD: Systematic computerised searches of PubMed, Web of Knowledge, Scopus, ENTRAL and CINAHL databases were performed from their inception to 20 January 2016. Randomised controlled trials (RCTs) were included in this systematic review. We used the Jadad scale as a quality assessment tool...
June 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28594976/patient-reported-outcome-measures-in-upper-airway-related-dyspnea-a-systematic-review
#9
Meaghan Noud, Kristen Hovis, Alexander Gelbard, Nila A Sathe, David F Penson, Irene D Feurer, Melissa L McPheeters, David O Francis
Importance: Patient-reported outcome (PRO) measures address the need for patient-centered data and are now used in diverse clinical, research, and policy pursuits. They are important in conditions causing upper airway-related dyspnea in which the patient's reported experience and physiological data can be discrepant. Objectives: To perform a systematic review of the literature on upper airway dyspnea-related PRO measures and to rigorously evaluate each measure's developmental properties, validation, and applicability...
June 8, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28591176/moxibustion-treatment-for-primary-osteoporosis-a-systematic-review-of-randomized-controlled-trials
#10
Fanping Xu, Minghua Huang, Yi Jin, Qingzhe Kong, Zhongmin Lei, Xu Wei
Primary osteoporosis (POP) has a serious impact on quality of life for middle-aged and elderly, which particularly increase the risk of fracture. We conducted the systematic review to evaluate the effects of moxibustion for POP in randomized controlled trials (RCTs).Eight databases were searched from their inception to July 30, 2016. The RCTs reporting the moxibustion as a monotherapy or in combination with conventional therapy for POP were enrolled. The outcomes might be fracture incidence, quality of life, clinical symptoms, death attributed to osteoporosis, adverse effect, bone mineral density (BMD), and biochemical indicators...
2017: PloS One
https://www.readbyqxmd.com/read/28585310/direct-acting-antivirals-for-chronic-hepatitis-c
#11
REVIEW
Janus C Jakobsen, Emil Eik Nielsen, Joshua Feinberg, Kiran Kumar Katakam, Kristina Fobian, Goran Hauser, Goran Poropat, Snezana Djurisic, Karl Heinz Weiss, Milica Bjelakovic, Goran Bjelakovic, Sarah Louise Klingenberg, Jian Ping Liu, Dimitrinka Nikolova, Ronald L Koretz, Christian Gluud
BACKGROUND: Millions of people worldwide suffer from hepatitis C, which can lead to severe liver disease, liver cancer, and death. Direct-acting antivirals (DAAs) are relatively new and expensive interventions for chronic hepatitis C, and preliminary results suggest that DAAs may eradicate hepatitis C virus (HCV) from the blood (sustained virological response). However, it is still questionable if eradication of hepatitis C virus in the blood eliminates hepatitis C in the body, and improves survival and leads to fewer complications...
June 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28583516/metabolomics-study-for-identification-of-potential-biomarkers-of-long-term-survival-in-kidney-transplantation-recipients
#12
S-K Lee, B K Kim, H-Y Jung, J-H Cho, S-H Park, Y-L Kim, S-Y Kim, Y-R Yoon, B H Chung, S-H Lee, C-D Kim
BACKGROUND: The recent progress and appropriate use of immunosuppressive drugs have considerably improved the short-term survival in kidney transplantation recipients (KTRs). The development of new strategies to improve long-term survival outcome after kidney transplantation is also becoming important. Although current diagnosis of allograft dysfunction relies on serum creatinine concentration and biopsy, they are nonspecific indicators of allograft function. Therefore, noninvasive, sensitive, and specific biomarkers for the prediction of long-term survival are needed...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28581310/patients-with-parkinson-s-disease-display-a-dopamine-therapy-related-negative-bias-and-an-enlarged-range-in-emotional-responses-to-facial-emotional-stimuli
#13
Daniel Lundqvist, Joakim Svärd, Åsa Michelgård Palmquist, Håkan Fischer, Per Svenningsson
OBJECTIVE: The literature on emotional processing in Parkinson's disease (PD) patients shows mixed results. This may be because of various methodological and/or patient-related differences, such as failing to adjust for cognitive functioning, depression, and/or mood. METHOD: In the current study, we tested PD patients and healthy controls (HCs) using emotional stimuli across a variety of tasks, including visual search, short-term memory (STM), categorical perception, and emotional stimulus rating...
June 5, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28580508/economics-of-early-warning-scores-for-identifying-clinical-deterioration-a-systematic-review
#14
A Murphy, J Cronin, R Whelan, F J Drummond, E Savage, J Hegarty
AIM: In 2013, a National Early Warning System (EWS) was implemented in Ireland. Whilst evidence exists to support the clinical effectiveness of EWS in the acute health care setting, there is a paucity of information on their cost and cost effectiveness. The objective of this systematic literature review was to critically evaluate the economic literature on the use of EWS in adult patients in acute health care settings for the timely detection of physiological deterioration. METHODS: A systematic literature review was conducted to accumulate the economic evidence on the use of EWS in adult patients in acute health care settings...
June 3, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28576500/the-efficacy-of-conventional-radiofrequency-denervation-in-patients-with-chronic-low-back-pain-originating-from-the-facet-joints-a-meta-analysis-of-randomized-controlled-trials
#15
REVIEW
Chang-Hyun Lee, Chun Kee Chung, Chi Heon Kim
BACKGROUND CONTEXT: Radiofrequency denervation is commonly used for the treatment of chronic facet joint pain that has been refractory to more conservative treatments, although the evidence supporting this treatment has been controversial. PURPOSE: We aimed to elucidate the precise effects of radiofrequency denervation in patients with low back pain originating from the facet joints relative to those obtained using control treatments, with particular attention to consistency in the denervation protocol...
May 30, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28573401/effects-of-supervised-vs-unsupervised-training-programs-on-balance-and-muscle-strength-in-older-adults-a-systematic-review-and-meta-analysis
#16
REVIEW
André Lacroix, Tibor Hortobágyi, Rainer Beurskens, Urs Granacher
BACKGROUND: Balance and resistance training can improve healthy older adults' balance and muscle strength. Delivering such exercise programs at home without supervision may facilitate participation for older adults because they do not have to leave their homes. To date, no systematic literature analysis has been conducted to determine if supervision affects the effectiveness of these programs to improve healthy older adults' balance and muscle strength/power. OBJECTIVES: The objective of this systematic review and meta-analysis was to quantify the effectiveness of supervised vs...
June 1, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28562502/prescribers-knowledge-and-skills-for-interpreting-research-results-a-systematic-review
#17
Leila Kahwati, Dennis Carmody, Nancy Berkman, Helen W Sullivan, Kathryn J Aikin, Jessica DeFrank
INTRODUCTION: Appropriate medication prescribing may be influenced by a prescriber's ability to understand and interpret medical research. The objective of this review was to synthesize the research related to prescribers' critical appraisal knowledge and skills-defined as the understanding of statistical methods, biases in studies, and relevance and validity of evidence. METHODS: We searched PubMed and other databases from January 1990 through September 2015. Two reviewers independently screened and selected studies of any design conducted in the United States, the United Kingdom, or Canada that involved prescribers and that objectively measured critical appraisal knowledge, skills, understanding, attitudes, or prescribing behaviors...
April 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/28553702/music-therapy-for-people-with-schizophrenia-and-schizophrenia-like-disorders
#18
REVIEW
Monika Geretsegger, Karin A Mössler, Łucja Bieleninik, Xi-Jing Chen, Tor Olav Heldal, Christian Gold
BACKGROUND: Music therapy is a therapeutic approach that uses musical interaction as a means of communication and expression. Within the area of serious mental disorders, the aim of the therapy is to help people improve their emotional and relational competencies, and address issues they may not be able to using words alone. OBJECTIVES: To review the effects of music therapy, or music therapy added to standard care, compared with placebo therapy, standard care or no treatment for people with serious mental disorders such as schizophrenia...
May 29, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28552028/invalid-before-impaired-an-emerging-paradox-of-embedded-validity-indicators
#19
Laszlo A Erdodi, Jonathan D Lichtenstein
OBJECTIVE: Embedded validity indicators (EVIs) are cost-effective psychometric tools to identify non-credible response sets during neuropsychological testing. As research on EVIs expands, assessors are faced with an emerging contradiction: the range of credible impairment disappears between the 'normal' and 'invalid' range of performance. We labeled this phenomenon as the invalid-before-impaired paradox. This study was designed to explore the origin of this psychometric anomaly, subject it to empirical investigation, and generate potential solutions...
May 27, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28544459/plaque-removal-with-triple-headed-vs-single-headed-manual-toothbrushes-a-systematic-review
#20
REVIEW
S M Kalf-Scholte, G A Van der Weijden, Ewp Bakker, D E Slot
OBJECTIVE: The aim of this systematic review was to establish the effectiveness of brushing with a triple-headed manual toothbrush compared to a single-headed manual toothbrush on plaque removal. MATERIALS AND METHODS: The MEDLINE-PubMed and Cochrane-CENTRAL databases were searched. The inclusion criteria were clinical trials conducted with humans without fixed orthodontic appliances who were not dental care professionals. Papers that evaluated the effect of toothbrushing with a triple-headed manual toothbrush compared to a single-headed manual toothbrush on plaque removal were included...
May 22, 2017: International Journal of Dental Hygiene
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