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https://www.readbyqxmd.com/read/29676638/identification-of-novel-targets-for-lung-cancer-therapy-using-an-induced-pluripotent-stem-cell-model
#1
Vivek Shukla, Mahadev Rao, Hongen Zhang, Jeanette Beers, Darawalee Wangsa, Danny Wangsa, Floryne O Buishand, Yonghong Wang, Zhiya Yu, Holly Stevenson, Emily Reardon, Kaitlin C McLoughlin, Andrew Kaufman, Eden Payabyab, Julie A Hong, Mary Zhang, Sean R Davis, Daniel C Edelman, Guokai Chen, Markku Miettinen, Nicholas Restifo, Thomas Ried, Paul S Meltzer, David S Schrump
RATIONALE: Despite extensive studies, the genetic and epigenetic mechanisms that mediate initiation and progression of lung cancers have not been fully elucidated. Previously, we have demonstrated that via complementary mechanisms, including DNA methylation, polycomb repressive complexes, and noncoding RNAs, cigarette smoke induces stem-like phenotypes that coincide with progression to malignancy in normal respiratory epithelia as well as enhanced growth and metastatic potential of lung cancer cells...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676534/consensus-based-european-guidelines-for-treatment-of-atopic-eczema-atopic-dermatitis-in-adults-and-children-part-i
#2
A Wollenberg, S Barbarot, T Bieber, S Christen-Zaech, M Deleuran, A Fink-Wagner, U Gieler, G Girolomoni, S Lau, A Muraro, M Czarnecka-Operacz, T Schäfer, P Schmid-Grendelmeier, D Simon, Z Szalai, J C Szepietowski, A Taïeb, A Torrelo, T Werfel, J Ring
This guideline was developed as a joint interdisciplinary European project, including physicians from all relevant disciplines as well as patients. It is a consensus-based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account. This first part of the guideline covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti-inflammatory therapy, phototherapy and antipruritic therapy, whereas the second part covers antimicrobial therapy, systemic treatment, allergen-specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions...
May 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29676072/current-management-of-moderate-to-severe-atopic-dermatitis-a-survey-of-allergists-pediatric-allergists-and-dermatologists-in-korea
#3
Hye Yung Yum, Hyun Hee Kim, Hyun Jung Kim, Woo Kyung Kim, So Yeon Lee, Kapsok Li, Dong Hun Lee
PURPOSE: There is an unmet need for the treatment of moderate-to-severe atopic dermatitis (AD), leading to variation in management strategies. To investigate distinct features and treatment modalities according to physicians' specialties, we collected data on the current treatment approach to moderate-to-severe AD among allergists, pediatric allergists and dermatologists in Korea. METHODS: This questionnaire-based study was administered to physicians from the Korean Academy of Asthma, Allergy and Clinical Immunology (KAAACI), Korean Academy of Pediatric Allergy and Respiratory Disease (KAPARD), and Korean Atopic Dermatitis Association (KADA)...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29675145/advances-in-targeting-the-folate-receptor-in-the-treatment-imaging-of-cancers
#4
REVIEW
Marcos Fernández, Faiza Javaid, Vijay Chudasama
The folate receptor (FR) is a recognised biomarker for tumour cells due to its overexpression on a large number of tumours. Consequently, the FR has been exploited by many diagnostic and therapeutic tools to allow targeted delivery to, and imaging of, cancer cells. Herein, we describe the many different approaches by which this has been achieved, including the attachment of folate to potent chemotherapeutic drugs to form FR-targeting small molecule-drug conjugates (SMDCs), FR-targeting antibodies (as antibody alone and as an antibody-drug conjugate), and in the form of complementary nanotechnology-folate platforms; as well as imaging variants thereof...
January 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674494/safety-and-efficacy-of-vorinostat-bortezomib-doxorubicin-and-dexamethasone-in-a-phase-i-ii-study-for-relapsed-or-refractory-multiple-myeloma-verumm-study-vorinostat-in-elderly-relapsed-and-unfit-multiple-myeloma
#5
Johannes M Waldschmidt, Alexander Keller, Gabriele Ihorst, Olga Grishina, Stefan Müller, Dagmar Wider, Anna V Frey, Kristina King, Roman Simon, Annette May, Pierfrancesco Tassone, Justus Duyster, Manfred Jung, Noopur Raje, Ralph Wäsch, Monika Engelhardt
This phase I/II trial was conducted to investigate the safety, efficacy, and pharmacodynamics of the pan-HDAC-inhibitor (HDACi) vorinostat combined with bortezomib, doxorubicin, and dexamethasone (VBDD) in patients suffering from relapsed/refractory multiple myeloma (RRMM). In the phase I part of this study, 9/33 patients received dose-escalated vorinostat (100, 200, 300mg), using a 4-day-on and 4-day-off schedule, and a standard 3+3 design. In the phase II part of the study, 24/33 patients were included to further assess VBDD's safety and efficacy...
April 19, 2018: Haematologica
https://www.readbyqxmd.com/read/29672167/sex-differences-in-opioid-use-and-medical-issues-during-buprenorphine-naloxone-treatment
#6
Celestina Barbosa-Leiker, Sterling McPherson, Matthew E Layton, Ekaterina Burduli, John M Roll, Walter Ling
BACKGROUND: There are sex differences in buprenorphine/naloxone clinical trials for opioid use. While women have fewer opioid-positive urine samples, relative to men, a significant decrease in opioid-positive samples was found during treatment for men, but not women. In order to inform sex-based approaches to improve treatment outcomes, research is needed to determine if opioid use, and predictors of opioid use, differs between men and women during treatment. OBJECTIVES: To test for sex differences in opioid use during a buprenorphine/naloxone clinical trial and determine if sex differences exist in the associations between addiction-related problem areas and opioid use over the course of the trial...
April 19, 2018: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29668401/phase-ii-randomized-controlled-trial-of-constraint-induced-movement-therapy-in-multiple-sclerosis-part-2-effect-on-white-matter-integrity
#7
Ameen Barghi, Jane B Allendorfer, Edward Taub, Brent Womble, Jarrod M Hicks, Gitendra Uswatte, Jerzy P Szaflarski, Victor W Mark
BACKGROUND: Constraint-induced movement therapy (CIMT) is a method of physical rehabilitation that has demonstrated clinical efficacy in patients with chronic stroke, cerebral palsy, and multiple sclerosis (MS). OBJECTIVE: This pilot randomized controlled trial tested whether CIMT can also induce increases in white matter integrity in patients with MS. METHODS: Twenty adults with chronic hemiparetic MS were randomized to receive either CIMT or complementary and alternative medicine (CAM) treatment (reported in the first article of this pair)...
March 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29668399/phase-ii-randomized-controlled-trial-of-constraint-induced-movement-therapy-in-multiple-sclerosis-part-1-effects-on-real-world-function
#8
Victor W Mark, Edward Taub, Gitendra Uswatte, David M Morris, Gary R Cutter, Terrie L Adams, Mary H Bowman, Staci McKay
BACKGROUND: Constraint-Induced Movement therapy (CIMT) has controlled evidence of efficacy for improving real-world paretic limb use in non-progressive physically disabling disorders (stroke, cerebral palsy). OBJECTIVE: This study sought to determine whether this therapy can produce comparable results with a progressive disorder such as multiple sclerosis (MS). We conducted a preliminary phase II randomized controlled trial of CIMT versus a program of complementary and alternative medicine (CAM) treatments for persons with MS, to evaluate their effect on real-world disability...
March 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29663878/role-of-angiogenenic-growth-factors-in-psoriasis-a-review
#9
Tahseena Akhtar, Willayat Yousuf Wani, Mohammad A Kamal, Rajinder Kaur
BACKGROUND: Psoriasis is a chronic inflammatory disease, involving autoimmune mechanism wherein immune system, autoantigens and various environmental triggers all interact to create the systemically diseased state. It is a multifactorial skin disease of complex nature characterized by infiltration of multiple immune cells, kerationcyte proliferation, and increased dermal vascularity. Among all factors, vascular alterations present a significant feature of the disease and angiogenesis seems to have an important role in giving rise to psoriasis phenotype...
April 16, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29662720/role-of-active-versus-passive-complementary-and-integrative-health-approaches-in-pain-management
#10
David Cosio, Erica Lin
Background: A general conclusion about the treatment of chronic, noncancer pain is that the results from traditional, passive modalities are disheartening. Perhaps this may be due to the propensity of patients to seek out passive versus active treatments. In pain management, active treatments should be the primary focus, with passive interventions as an adjunct. Objective: The current study tested the hypotheses that Veterans would report a greater significant increase in active versus transitional and active versus passive complementary and integrative health (CIH) utilization after completing a formal pain education program...
2018: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/29656441/a-review-on-current-status-of-antiviral-sirna
#11
REVIEW
Abid Qureshi, Vaqar Gani Tantray, Altaf Rehman Kirmani, Abdul Ghani Ahangar
Viral diseases like influenza, AIDS, hepatitis, and Ebola cause severe epidemics worldwide. Along with their resistant strains, new pathogenic viruses continue to be discovered so creating an ongoing need for new antiviral treatments. RNA interference is a cellular gene-silencing phenomenon in which sequence-specific degradation of target mRNA is achieved by means of complementary short interfering RNA (siRNA) molecules. Short interfering RNA technology affords a potential tractable strategy to combat viral pathogenesis because siRNAs are specific, easy to design, and can be directed against multiple strains of a virus by targeting their conserved gene regions...
April 15, 2018: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29656263/early-improvement-as-a-predictor-of-final-remission-in-major-depressive-disorder-new-insights-in-electroconvulsive-therapy
#12
Erika Martínez-Amorós, Ximena Goldberg, Verònica Gálvez, Aida de Arriba-Arnau, Virginia Soria, José M Menchón, Diego J Palao, Mikel Urretavizcaya, Narcís Cardoner
BACKGROUND: Early improvement to antidepressant drugs predicts remission, but the predictive value of early improvement to electroconvulsive therapy (ECT) is still unclear. The main aim of this study was to determine the optimal definition of early improvement in the treatment of major depressive disorder (MDD) with ECT, by analyzing its value as a predictor of remission. METHODS: A naturalistic study was conducted in 87 adult MDD patients treated with acute ECT...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29651548/-diagnosis-of-dry-eye-disease
#13
C Jacobi, E M Messmer
Dry eye disease (DED) is one of the most common ophthalmological diseases with an increasing prevalence in recent years. Numerous general and ocular risk factors exist for the development of DED. The pathogenesis of DED is multifactorial and complex, characterized by a loss of homeostasis of the tear film, inflammatory mechanisms at the ocular surface, hyperosmolarity of tears and neurosensory abnormalities. DED is classified into the two sub-categories, aqueous deficient dry eye and evaporative dry eye. Apart from a detailed patient history, basic and complementary diagnostic tests are necessary to enable an individualized and efficient therapy...
April 12, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29651051/collagen-iv-conveyed-signals-can-regulate-chemokine-production-and-promote-liver-metastasis
#14
George Vaniotis, Roni F Rayes, Shu Qi, Simon Milette, Ni Wang, Stephanie Perrino, France Bourdeau, Hanna Nyström, Yi He, Nathalie Lamarche-Vane, Pnina Brodt
Liver metastases remain a major cause of death from gastrointestinal tract cancers as well as from other malignancies such as breast and lung carcinomas and melanoma. Understanding the underlying biology is essential for the design of effective targeted therapies. We previously reported that collagen IV α1/α2 overexpression in non-metastatic lung carcinoma (M27colIV ) cells increased their metastatic ability, specifically to the liver and documented high collagen IV levels in surgical resections of liver metastases from diverse tumor types...
April 13, 2018: Oncogene
https://www.readbyqxmd.com/read/29650696/npy-induces-stress-resilience-via-down-regulation-of-i-h-in-principal-neurons-of-rat-basolateral-amygdala
#15
Heika Silveira Villarroel, Maria Bompolaki, James Mackay, Ana Pamela Miranda Tapia, Sheldon D Michaelson, Randy J Leitermann, Robert A Marr, Janice H Urban, William F Colmers
Neuropeptide Y (NPY) expression is tightly linked with the development of stress resilience in rodents and humans. Local NPY injections targeting the basolateral amygdala (BLA) produce long-term behavioral stress resilience in male rats via an unknown mechanism. Previously, we showed that activation of NPY Y1 receptors hyperpolarizes BLA principal neurons (PNs) through inhibition of the hyperpolarization-activated, depolarizing H-current, Ih The present studies tested whether NPY treatment induces stress resilience by modulating Ih NPY (10 pmol) was delivered daily for 5 days bilaterally into the BLA to induce resilience; thereafter the electrophysiological properties of PNs and the expression of Ih in the BLA were characterized...
April 12, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29650239/lifestyle-therapy-for-the-management-of-atrial-fibrillation
#16
REVIEW
Ahmad A Abdul-Aziz, Mahmoud Altawil, Amanda Lyon, Mark MacEachern, Caroline R Richardson, Melvyn Rubenfire, Frank Pelosi, Elizabeth A Jackson
Atrial fibrillation (AF) is a common arrhythmia associated with increased risk of morbidity and mortality. There is evidence that lifestyle interventions may serve as complementary treatments to reduce AF burden. The objective of this review was to summarize the efficacy of lifestyle interventions for the management of AF. Studies which included patients with systolic heart failure (ejection fraction ≤40%), and those limited to an examination of vigorous physical activity were excluded from our search. Studies were identified through a search of the following databases: MEDLINE, EMBASE, CINAHIL, and PubMed, run from inception through August 2016...
February 7, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29648560/multifunctional-hybrids-with-versatile-types-of-nanoparticles-via-self-assembly-for-complementary-tumor-therapy
#17
Shun Duan, Jia Li, Nana Zhao, Fu-Jian Xu
Self-assembly is a promising method for the construction of multifunctional nanohybrids for biomedical application. In this work, self-assembled multifunctional nanohybrids with a controllable disassembly property have been successfully fabricated. By modification with cyclodextrin (CD)-decorated ethylenediamine-functionalized poly(glycidyl methacrylate) (PGED), CD groups and polycations were conjugated onto Au nanorods (Au NRs) or Fe3O4 nanoparticles (denoted as Au-PGED-CD or Fe3O4-PGED-CD), and different SiO2@Fe3O4-PGED (SFP) or SiO2@Au-PGED (SAP) nanohybrids were readily fabricated by the host-guest interaction between Au-PGED-CD or Fe3O4-PGED-CD and adamantyl (Ad)-functionalized chiral silica NRs under mild conditions...
April 12, 2018: Nanoscale
https://www.readbyqxmd.com/read/29643985/replication-incompetent-gammaretroviral-and-lentiviral-vector-based-insertional-mutagenesis-screens-identify-prostate-cancer-progression-genes
#18
Victor M Bii, Casey P Collins, Jonah D Hocum, Grant D Trobridge
Replication-incompetent gammaretroviral (γRV) and lentiviral (LV) vectors have both been used in insertional mutagenesis screens to identify cancer drivers. In this approach the vectors stably integrate in the host cell genome and induce cancers by dysregulating nearby genes. The cells that contain a retroviral vector provirus in or near a proto-oncogene or tumor suppressor are preferentially enriched in a tumor. γRV and LV vectors have different integration profiles and genotoxic potential, making them potentially complementary tools for insertional mutagenesis screens...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29643431/an-estradiol-independent-bdnf-npy-cascade-is-involved-in-the-antidepressant-effect-of-mechanical-acupuncture-instruments-in-ovariectomized-rats
#19
Su Yeon Seo, Ji-Young Moon, Suk-Yun Kang, O Sang Kwon, Sunoh Kwon, Se Kyun Bang, Soo Phil Kim, Kwang-Ho Choi, Yeonhee Ryu
Menopause-related depression devastates women's quality of life after middle age. Previous research has shown that estrogen hormone therapy has serious adverse effects; thus, complementary and integrative therapies have been considered clinically. The present study investigates whether stimulation of an acupoint using a mechanical acupuncture instrument (MAI) can mitigate depression-like behavior caused by estrogen deficiency in ovariectomized (OVX) rats. The animals were divided into Sham OVX, OVX, OVX + Sameumgyo (SP6) and OVX + NonAcu (non-acupuncture point) groups...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29630121/the-additional-role-of-18f-fdg-pet-ct-in-prosthetic-valve-endocarditis
#20
S Nuvoli, V Fiore, S Babudieri, S Galassi, P Bagella, P Solinas, A Spanu, G Madeddu
OBJECTIVE: The purpose of the present review is an update on the diagnosis of prosthetic valve endocarditis (PVE), evaluating the additional value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to the standard modified DUKE criteria on which for a long time is based the diagnostic strategy of the disease. MATERIALS AND METHODS: We did a comprehensive research on the studies reported in the literature and regarding the employment of 18F-FDG PET/CT in the early diagnosis of PVE in patients with suspected disease...
March 2018: European Review for Medical and Pharmacological Sciences
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