Sean G Byars, Priscilla Prestes, Vara Suphapimol, Fumihiko Takeuchi, Nathan De Vries, Michelle C Maier, Mariana Melo, David Balding, Nilesh Samani, Andrew M Allen, Norihiro Kato, Jennifer L Wilkinson-Berka, Fadi Charchar, Stephen B Harrap
AIMS: Prevention of human hypertension is an important challenge and has been achieved in experimental models. Brief treatment with renin-angiotensin system (RAS) inhibitors permanently reduces the genetic hypertension of the spontaneously hypertensive rat (SHR). The kidney is involved in this fascinating phenomenon, but relevant changes in gene expression are unknown. METHODS: In SHR, we studied the effect of treatment between 10 and 14 weeks of age with the angiotensin receptor blocker, losartan, or the angiotensin-converting enzyme (ACE) inhibitor, perindopril (with controls for non-specific effects of lowering BP) on differential RNA expression, DNA methylation and renin immunolabelling in the kidney at 20 weeks of age...
March 19, 2024: Cardiovascular Research