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https://www.readbyqxmd.com/read/28134629/liguzinediol-enhances-the-inotropic-effect-of-rat-hearts-via-inhibition-of-protein-phosphatase-pp1-and-pp2a-activities
#1
Sha Li, Huili Huang, Mengdan Zhang, Wei Wang, Shuyin Xue, Ying Gao, Ming Xie, Kesu Chen, Fuming Liu, Long Chen
It has been demonstrated that Liguzinediol (LZDO), a derivative of ligustrazine from ligusticum wallichii Franch, exerts positive inotropy in isolated rat heart mediated by the sarcoplasmic reticulum Ca-ATPase (SERCA2a). Here, we further explore the underlying mechanism of the positive inotropic effect of LZDO in rat hearts. In vivo and ex vivo rat heart experiments, biochemistry and Western blot techniques were used to analyze the rat heart contractility, SERCA2a activity, phospholamban (PLB) phosphorylation and protein phosphatase (PP1 and PP2A) activities in rat left ventricular myocytes, respectively...
January 27, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28062615/biochemistry-therapeutics-and-biomarker-implications-of-neprilysin-in-cardiorenal-disease
#2
REVIEW
Yang Chen, John C Burnett
BACKGROUND: Neprilysin (NEP) is a membrane-bound neutral endopeptidase that degrades a variety of bioactive peptides. The substrates include natriuretic peptides (NPs), which are important regulating mediators for cardiovascular and renal biology. Inhibition of NEP activity and exogenous NP administration thus have emerged as potential therapeutic strategies for treating cardiorenal diseases. More recently, B-type natriuretic peptide (BNP) or N-terminal-proBNP (NT-proBNP), 3'-5' cyclic guanosine monophosphate (cGMP), and soluble NEP as biomarkers have also been investigated in heart failure (HF) trials and their predictive value are beginning to be recognized...
January 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28025056/non-malignant-pleural-effusions-nmpe-a-prospective-study-of-356-consecutive-unselected-patients
#3
Steven P Walker, Anna J Morley, Louise Stadon, Duneesha De Fonseka, David A Arnold, Andrew Rl Medford, Nick A Maskell
BACKGROUND: Pleural effusions secondary to a non-malignant aetiology can represent significant morbidity and mortality. These non-malignant pleural effusions (NMPE) are common, with congestive heart failure (CHF) representing the leading cause. Despite this, there is limited data on mortality risk and the factors which influence them. METHODS: We recruited 782 consecutive patients presenting to a pleural service, between 03/2008 and 03/2015, with an undiagnosed pleural effusion...
December 23, 2016: Chest
https://www.readbyqxmd.com/read/28007527/applications-of-higenamine-in-pharmacology-and-medicine
#4
REVIEW
Nana Zhang, Zeqin Lian, Xueying Peng, Zijian Li, Haibo Zhu
ETHNOPHARMACOLOGICAL RELEVANCE: Aconitum has been used as local and traditional medicines in many asian regions for the treatment of various diseases such as collapse, syncope, painful joints, oedema, bronchial asthma et al. Higenamine, a plant-based alkaloid, was initially isolated from Aconitum and identified as the active cardiotonic component of Aconitum. It has been tested as a candidate of pharmacologic stress agent in the detection of coronary artery diseases (CADs) and now researchers have just accomplished the phase III clinical studies successfully in China...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27872995/nt-probnp-as-marker-of-ventricular-dilatation-and-pulmonary-regurgitation-after-surgical-correction-of-tetralogy-of-fallot-a-mri-validation-study
#5
Annalisa Paolino, Tarique Hussain, Antonio Pavon, Maria Nieves Velasco, Sergio Uribe, Antonio Ordoñez, Israel Valverde
The goal of this study is to evaluate whether NT-proBNP plasma levels may help as a screening biomarker for monitoring right ventricular dilatation, pulmonary regurgitation and the onset of heart failure in patients with repaired Tetralogy of Fallot. Our single-centre observational prospective study involved 43 patients (15.1 years, SD = 8) with corrected Tetralogy of Fallot. Data collection included: clinical parameters (electrocardiogram, chest X-ray, NYHA scale, time since last surgery), biochemistry (NT-proBNP levels) and MRI values (ventricular volumetry, pulmonary flow assessment)...
November 21, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27788389/the-association-of-admission-blood-glucose-level-with-the-clinical-picture-and-prognosis-in-cardiogenic-shock-results-from-the-cardshock-study
#6
Anu Kataja, Tuukka Tarvasmäki, Johan Lassus, Jose Cardoso, Alexandre Mebazaa, Lars Køber, Alessandro Sionis, Jindrich Spinar, Valentina Carubelli, Marek Banaszewski, Rossella Marino, John Parissis, Markku S Nieminen, Veli-Pekka Harjola
BACKGROUND: Critically ill patients often present with hyperglycemia, regardless of previous history of diabetes mellitus (DM). Hyperglycemia has been associated with adverse outcome in acute myocardial infarction and acute heart failure. We investigated the association of admission blood glucose level with the clinical picture and short-term mortality in cardiogenic shock (CS). METHODS: Consecutively enrolled CS patients were divided into five categories according to plasma glucose level at the time of enrolment: hypoglycemia (glucose <4...
January 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27748500/the-differences-in-the-relationship-between-diastolic-dysfunction-selected-biomarkers-and-collagen-turn-over-in-heart-failure-patients-with-preserved-and-reduced-ejection-fraction
#7
Błażej Michalski, Przemysław Trzciński, Karolina Kupczyńska, Dawid Miśkowiec, Łukasz Pęczek, Barbara Nawrot, Piotr Lipiec, Jarosław D Kasprzak
BACKGROUND: The aim of the study was to assess the correlation of the selected biomarkers and collagen turn-over indices with advanced echocardiographic parameters among patients with preserved and reduced ejection fraction (EF). METHODS: We included 62 patients with the symptomatic heart failure. The patients were divided in to two groups according to the evaluated ejection fraction (EF - Simpson method): heart failure with reduced ejection fraction (HFrEF) group - 30 patients with low EF - 35-50% (16 male, mean age 54...
2017: Cardiology Journal
https://www.readbyqxmd.com/read/27683533/analytical-issues-with-natriuretic-peptides-has-this-been-overly-simplified
#8
Alexander G Semenov, Alexey G Katrukha
Natriuretic peptides (NPs) were first described as cardiac biomarkers more than two decades ago. Since that time, numerous studies have confirmed NPs' diagnostic and prognostic utilities as biomarkers of myocardial function. However, we must now admit that despite the NPs' relatively long period of use in clinical practice, our understanding of the biochemistry and the variety of circulating forms of NPs, as well as of their potential as biomarkers, remains far from being complete and comprehensive. The highly complex nature and wide diversity of circulating forms of NPs make their accurate measurements in plasma far more complex than initially believed...
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27639971/management-of-suspected-acute-heart-failure-dyspnea-in-the-emergency-department-results-from-the-french-prospective-multicenter-defssica-survey
#9
Tahar Chouihed, Stéphane Manzo-Silberman, Nicolas Peschanski, Sandrine Charpentier, Meyer Elbaz, Dominique Savary, Eric Bonnefoy-Cudraz, Said Laribi, Patrick Henry, Nicolas Girerd, Faiez Zannad, Carlos El Khoury
BACKGROUND: An appropriate diagnostic process is crucial for managing patients with acute heart failure (AHF) in emergency department (ED). Our study aims to describe the characteristics and therapeutic management of patients admitted to the ED for dyspnea suspected to have AHF, their in-hospital pathway of care and their in-hospital outcome. METHODS: Consecutive patients admitted in 26 French ED for dyspnea suspected to be the consequence of AHF, prior to in hospital diagnostic test, were prospectively included at the time of their admission in the DeFSSICA Survey...
September 17, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27467771/slower-decline-in-c-reactive-protein-after-an-inflammatory-insult-is-associated-with-longer-survival-in-older-hospitalised-patients
#10
Maryam Barma, James A Goodbrand, Peter T Donnan, Mark M McGilchrist, Helen Frost, Marion E T McMurdo, Miles D Witham
BACKGROUND: Enhancing biological resilience may offer a novel way to prevent and ameliorate disease in older patients. We investigated whether changes in C-reactive protein (CRP), as a dynamic marker of the acute inflammatory response to diverse stressors, may provide a way to operationalize the concept of resilience in older adults. We tested this hypothesis by examining whether such changes could predict prognosis by identifying which individuals are at greater risk of 6-month mortality...
2016: PloS One
https://www.readbyqxmd.com/read/27414721/surfactant-protein-b-from-biochemistry-to-its-potential-role-as-diagnostic-and-prognostic-marker-in-heart-failure
#11
REVIEW
Cristina Banfi, Piergiuseppe Agostoni
Growing interest raised on circulating biomarkers of structural alveolar-capillary unit damage and very recent data support surfactant protein type B (SP-B) as the most promising candidate in this setting. With respect to other proteins proposed as possible markers of lung damage, SP-B has some unique qualities: it is critical for the assembly of pulmonary surfactant, making its lack incompatible with life; it has no other known site of synthesis except alveolar epithelial cells different from other surfactant proteins; and, it undergoes a proteolytic processing in a pulmonary-cell-specific manner...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27352948/what-impacts-do-anxiety-depression-perceived-control-and-technology-capability-have-on-whether-patients-with-chronic-heart-failure-take-up-or-continue-to-use-home-tele-monitoring-services-study-design-of-adapt-hf
#12
Amanda Crundall-Goode, Kevin M Goode, Andrew L Clark
BACKGROUND: Home tele-monitoring (HTM) is used to monitor the clinical signs and symptoms of patients with chronic heart failure (CHF) in order to reduce unplanned hospital admissions. However, not all patients who are referred will agree to use HTM, and some patients choose to withdraw early from its use. AIMS: ADaPT-HF will investigate whether depression, anxiety, low perceived control, reduced technology capability, level of education, age or the severity or complexity of a patient's illness can predict refusal of, or early withdrawal from, HTM in patients with CHF...
June 28, 2016: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/27277367/prognostic-role-of-multiple-cardiac-biomarkers-in-newly-diagnosed-acute-coronary-syndrome-patients
#13
M M Rahman, M M Alam, N A Jahan, J S Shila, M I Arslam
Acute coronary syndrome includes unstable angina and myocardial infarction with or without ST-segment elevation, is life-threatening disorders that remain a source of high morbidity and mortality despite advances in treatment. The aim of the study was to evaluate the prognostic role of serum cTnI, CK-MB, hsCRP, MPO and BNP in newly diagnosed acute coronary syndrome patients. This cohort study was carried out in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University in cooperation with the Department of Cardiology, BSMMU and NICVD during the period of March 2013 to February 2014...
April 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27036051/renin-angiotensin-aldosterone-signaling-inhibitors-losartan-enalapril-and-cardosten-prevent-infarction-induced-heart-failure-development-in-rats
#14
Krisztina Kiss, Veronika Fekete, János Pálóczi, Márta Sárközy, Zsolt Murlasits, Judit Pipis, Irina A Kheyfets, Julia L Dugina, Svetlana A Sergeeva, Oleg I Epstein, Csaba Csonka, Tamás Csont, Péter Ferdinandy, Péter Bencsik
CONTEXT: The activation of the renin-angiotensin-aldosterone system (RAAS) plays an important role in the pathophysiology of congestive heart failure, which is the reason that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin 2 receptor blockers (ARBs) have become established therapies for heart failure. However, it is still not known whether preventive treatment with losartan or enalapril can reduce symptoms of infarction-induced heart failure. Ultra-low dose (ULD) drug therapy is thought to exert specific activity, with a lower chance of side effects...
March 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/26733606/isoproterenol-promotes-rapid-ryanodine-receptor-movement-to-bridging-integrator-1-bin1-organized-dyads
#15
Ying Fu, Seiji A Shaw, Robert Naami, Caresse L Vuong, Wassim A Basheer, Xiuqing Guo, TingTing Hong
BACKGROUND: The key pathophysiology of human acquired heart failure is impaired calcium transient, which is initiated at dyads consisting of ryanodine receptors (RyRs) at sarcoplasmic reticulum apposing CaV1.2 channels at t-tubules. Sympathetic tone regulates myocardial calcium transients through β-adrenergic receptor (β-AR)-mediated phosphorylation of dyadic proteins. Phosphorylated RyRs (P-RyR) have increased calcium sensitivity and open probability, amplifying calcium transient at a cost of receptor instability...
January 26, 2016: Circulation
https://www.readbyqxmd.com/read/26597355/determinants-and-prognostic-impact-of-hyperuricemia-in-hospitalization-for-acute-heart-failure
#16
Wei-Ming Huang, Pai-Feng Hsu, Hao-Min Cheng, Dai-Yin Lu, Yu-Lun Cheng, Chao-Yu Guo, Shih-Hsien Sung, Wen-Chung Yu, Chen-Huan Chen
BACKGROUND: Hyperuricemia is a prognostic factor in patients with chronic heart failure, but whether uric acid level can predict clinical outcome of acute heart failure (AHF) remains to be elucidated. We therefore investigated the association of uric acid with mortality in patients hospitalized for AHF. METHODS AND RESULTS: Data for patients hospitalized for AHF were drawn from an intramural registry. Biochemistry data, echocardiographic characteristics, and uric acid level were collected...
2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/26514241/novel-functionalized-5-phenoxymethyl-1-3-dioxane-analogs-exhibiting-cytochrome-p450-inhibition-a-patent-evaluation-wo2015048311-a1
#17
Richard L Schroeder, Phan Tram, Jiawang Liu, Maryam Foroozesh, Jayalakshmi Sridhar
Cytochrome P450's (CYP's) constitute a diverse group of over 500 monooxygenase hemoproteins, catalyzing transformations that involve xenobiotic metabolism, steroidogenesis and other metabolic processes. Over-production of the steroid hormone cortisol is implicated in the progression of diseases such as diabetes, heart failure and hypertension, stroke, Cushing's syndrome, obesity and renal failure, among others. The biosynthesis of cortisol involves a cascade of cholesterol metabolizing reactions regulated through three major CYP proteins: 17α-hydroxylase-C17/20-lyase (CYP17), 21-hydroxylase (CYP21), and 11β-hydroxylase (CYP11B1)...
2016: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/26274906/free-fatty-acid-effects-on-the-atrial-myocardium-membrane-ionic-currents-are-remodeled-by-the-disruption-of-t-tubular-architecture
#18
Ryan P O'Connell, Hassan Musa, Mario San Martin Gomez, Uma Mahesh Avula, Todd J Herron, Jerome Kalifa, Justus M B Anumonwo
BACKGROUND: Epicardial adiposity and plasma levels of free fatty acids (FFAs) are elevated in atrial fibrillation, heart failure and obesity, with potentially detrimental effects on myocardial function. As major components of epicardial fat, FFAs may be abnormally regulated, with a potential to detrimentally modulate electro-mechanical function. The cellular mechanisms underlying such effects of FFAs are unknown. OBJECTIVE: To determine the mechanisms underlying electrophysiological effects of palmitic (PA), stearic (SA) and oleic (OA) FFAs on sheep atrial myocytes...
2015: PloS One
https://www.readbyqxmd.com/read/26148383/the-efficacy-of-tolvaptan-as-a-diuretic-for-chronic-kidney-disease-patients
#19
Akihito Tanaka, Takayuki Katsuno, Takenori Ozaki, Fumiko Sakata, Noritoshi Kato, Yasuhiro Suzuki, Tomoki Kosugi, Sawako Kato, Naotake Tsuboi, Waichi Sato, Yoshinari Yasuda, Masashi Mizuno, Yasuhiko Ito, Seiichi Matsuo, Shoichi Maruyama
BACKGROUND: Tolvaptan selectively binds to the vasopressin V2 receptor and inhibits reabsorption of free water. Although its efficacy for heart failure has been proven, its efficacy for chronic kidney disease (CKD) patients has not been assessed in detail. METHODS: We examined 20 CKD patients (13 men and 7 women) who presented with volume overload and who were administered tolvaptan. We assessed urine volume (UV) and blood biochemistry before administration (dO), 1 day after administration (d1), and 7 to 14 days after administration (d7-14)...
April 2015: Acta Cardiologica
https://www.readbyqxmd.com/read/25933982/hydrogen-sulfide-in-pharmacology-and-medicine-an-update
#20
REVIEW
Jerzy Bełtowski
Hydrogen sulfide (H2S) is the endogenously produced gasotransmitter involved in the regulation of nervous system, cardiovascular functions, inflammatory response, gastrointestinal system and renal function. Together with nitric oxide and carbon monoxide, H2S belongs to a family of gasotransmitters. H2S is synthesized from L-cysteine and/or L-homocysteine by cystathionine β-synthase, cystathionine γ-lyase and cysteine aminotransferase together with 3-mercaptopyruvate sulfurtransferase. Significant progress has been made in recent years in our understanding of H2S biochemistry, signaling mechanisms and physiological role...
June 2015: Pharmacological Reports: PR
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