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https://www.readbyqxmd.com/read/28646272/rhesus-cochlear-and-vestibular-functions-are-preserved-after-inner-ear-injection-of-saline-volume-sufficient-for-gene-therapy-delivery
#1
Chenkai Dai, Mohamed Lehar, Daniel Q Sun, Lani Swarthout Rvt, John P Carey, Tim MacLachlan, Doug Brough, Hinrich Staecker, Alexandra M Della Santina, Timothy E Hullar, Charles C Della Santina
Sensorineural losses of hearing and vestibular sensation due to hair cell dysfunction are among the most common disabilities. Recent preclinical research demonstrates that treatment of the inner ear with a variety of compounds, including gene therapy agents, may elicit regeneration and/or repair of hair cells in animals exposed to ototoxic medications or other insults to the inner ear. Delivery of gene therapy may also offer a means for treatment of hereditary hearing loss. However, injection of a fluid volume sufficient to deliver an adequate dose of a pharmacologic agent could, in theory, cause inner ear trauma that compromises functional outcome...
June 23, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28639437/ultrasound-assisted-green-economic-synthesis-of-hydroxyapatite-nanoparticles-using-eggshell-bio-waste-and-study-of-mechanical-and-biological-properties-for-orthopaedic-applications
#2
Vijay H Ingole, Kamal Hany Hussein, Anil A Kashale, Kalyani Ghule, Tomaž Vuherer, Vanja Kokol, Jia-Yaw Chang, Yong-Chien Ling, Aruna Vinchurkar, Hom N Dhakal, Anil V Ghule
Nanostructured hydroxyapatite (HAp) is most favorable candidate biomaterial for bone tissue engineering because of its bioactive and osteoconductive properties. Herein, we report for the first time ultrasound assisted facile and economic approach for the synthesis of nanocrystalline hydroxyapatite (Ca10 (PO4 )6 (OH)2 ) using recycled eggshell bio-waste referred as EHAp. The process involves the reaction of eggshell bio-waste as a source of calcium and ammonium dihydrogen orthophosphate as a phosphate source...
June 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28625591/prognostic-significance-of-a-negative-confirmatory-biopsy-on-reclassification-among-men-on-active-surveillance
#3
Vishnu Ganesan, Charles Dai, Yaw A Nyame, Daniel J Greene, Nima Almassi, Daniel Hettel, Joseph Zabell, Hans Arora, Samuel Haywood, Alice Crane, Chad Reichard, Anna Zampini, Ahmed Elshafei, Robert J Stein, Khaled Fareed, J Stephen Jones, Michael Gong, Andrew J Stephenson, Eric A Klein, Ryan K Berglund
OBJECTIVE: To examine the association between absence of disease on confirmatory biopsy and risk of pathologic reclassification in men on active surveillance (AS). METHODS: Men with grade groups 1 and 2 disease on AS between 2002 and 2015 were identified who received a confirmatory biopsy within 1 year of diagnosis and ≥3 biopsies overall. The primary outcomes were pathologic reclassification by grade (any increase in primary Gleason pattern or Gleason score) or volume (>33% of sampled cores involved or increase in the number of cores with >50% involvement)...
June 15, 2017: Urology
https://www.readbyqxmd.com/read/28619260/neural-correlates-of-decision-making-on-whole-body-yaw-rotation-an-fnirs-study
#4
K N de Winkel, A Nesti, H Ayaz, H H Bülthoff
Prominent accounts of decision making state that decisions are made on the basis of an accumulation of sensory evidence, orchestrated by networks of prefrontal and parietal neural populations. Here we assess whether these findings generalize to decisions on self-motion. Participants were presented with whole body yaw rotations of different durations in a 2-Interval-Forced-Choice paradigm, and tasked to discriminate motions on the basis of their amplitude. The cortical hemodynamic response was recorded using functional near-infrared spectroscopy (fNIRS) while participants were performing the task...
June 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28619119/transmission-of-a-novel-sonotubometry-acoustic-click-stimulus-in-healthy-and-patulous-eustachian-tube-subjects-a-retrospective-case-control-study
#5
Justin M Pyne, Yaw Amoako-Tuffour, Guy Earle, Graham McIntyre, Michael B Butler, Manohar Bance
BACKGROUND: Eustachian tube (ET) dysfunction can be very difficult to diagnose accurately. Our aim is to determine whether a newly developed sonotubometric test using clicks can reliably detect ET opening during swallowing in normal ET subjects, and patulous ET (PET) in subjects with ET dysfunction. METHODS: Sixteen subjects (19 normal ET ears and 6 PET ears) were individually placed in a sound-isolated audiometry booth and subjected to a 1000Hz click train stimulus, played through the nose...
June 15, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28615260/predictors-of-anemia-in-preschool-children-biomarkers-reflecting-inflammation-and-nutritional-determinants-of-anemia-brinda-project
#6
REVIEW
Reina Engle-Stone, Grant J Aaron, Jin Huang, James P Wirth, Sorrel Ml Namaste, Anne M Williams, Janet M Peerson, Fabian Rohner, Ravi Varadhan, O Yaw Addo, Victor Temple, Pura Rayco-Solon, Barbara Macdonald, Parminder S Suchdev
Background: A lack of information on the etiology of anemia has hampered the design and monitoring of anemia-control efforts.Objective: We aimed to evaluate predictors of anemia in preschool children (PSC) (age range: 6-59 mo) by country and infection-burden category.Design: Cross-sectional data from 16 surveys (n = 29,293) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project were analyzed separately and pooled by category of infection burden. We assessed relations between anemia (hemoglobin concentration <110 g/L) and severe anemia (hemoglobin concentration <70 g/L) and individual-level (age, anthropometric measures, micronutrient deficiencies, malaria, and inflammation) and household-level predictors; we also examined the proportion of anemia with concomitant iron deficiency (defined as an inflammation-adjusted ferritin concentration <12 μg/L)...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28615256/adjusting-soluble-transferrin-receptor-concentrations-for-inflammation-biomarkers-reflecting-inflammation-and-nutritional-determinants-of-anemia-brinda-project
#7
REVIEW
Fabian Rohner, Sorrel Ml Namaste, Leila M Larson, O Yaw Addo, Zuguo Mei, Parminder S Suchdev, Anne M Williams, Fayrouz A Sakr Ashour, Rahul Rawat, Daniel J Raiten, Christine A Northrop-Clewes
Background: Iron deficiency is thought to be one of the most prevalent micronutrient deficiencies globally, but an accurate assessment in populations who are frequently exposed to infections is impeded by the inflammatory response, which causes iron-biomarker alterations.Objectives: We assessed the relation between soluble transferrin receptor (sTfR) concentrations and inflammation and malaria in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y) and investigated adjustment algorithms to account for these effects...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28615255/adjusting-total-body-iron-for-inflammation-biomarkers-reflecting-inflammation-and-nutritional-determinants-of-anemia-brinda-project
#8
REVIEW
Zuguo Mei, Sorrel Ml Namaste, Mary Serdula, Parminder S Suchdev, Fabian Rohner, Rafael Flores-Ayala, O Yaw Addo, Daniel J Raiten
Background: Total body iron (TBI) that is calculated from ferritin and soluble transferrin receptor (sTfR) allows for the evaluation of the full range of iron status from deficiency to excess. However, both ferritin and sTfR are affected by inflammation and malaria, which may require a statistical adjustment. TBI has been used to assess iron status in the United States, but its use worldwide and in settings with inflammation has been limited.Objective: We examine whether inflammation-adjusted ferritin and sTfR concentrations affect TBI values and the prevalence of low TBI (<0 mg/kg) in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y)...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28615251/adjusting-retinol-binding-protein-concentrations-for-inflammation-biomarkers-reflecting-inflammation-and-nutritional-determinants-of-anemia-brinda-project
#9
REVIEW
Leila M Larson, Sorrel Ml Namaste, Anne M Williams, Reina Engle-Stone, O Yaw Addo, Parminder S Suchdev, James P Wirth, Victor Temple, Mary Serdula, Christine A Northrop-Clewes
Background: The accurate estimation of the prevalence of vitamin A deficiency (VAD) is important in planning and implementing interventions. Retinol-binding protein (RBP) is often used in population surveys to measure vitamin A status, but its interpretation is challenging in settings where inflammation is common because RBP concentrations decrease during the acute-phase response.Objectives: We aimed to assess the relation between RBP concentrations and inflammation and malaria in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y) and to investigate adjustment algorithms to account for these effects...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28611026/map4k4-impairs-energy-metabolism-in-endothelial-cells-and-promotes-insulin-resistance-in-obesity
#10
Rachel J Roth Flach, Marina T DiStefano, Laura V Danai, Ozlem Senol-Cosar, Joseph C Yawe, Mark Kelly, Lorena Garcia Menendez, Michael P Czech
The blood vasculature responds to insulin, influencing hemodynamic changes in the periphery, which promotes tissue nutrient and oxygen delivery and thus metabolic function. The lymphatic vasculature regulates fluid and lipid homeostasis, and impaired lymphatic function can contribute to atherosclerosis and obesity. Recent studies have suggested a role for endothelial cell (EC) Mitogen activated protein kinase kinase kinase kinase 4 (Map4k4) in developmental angiogenesis and lymphangiogenesis as well as atherosclerosis...
June 13, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28590422/wearable-sensor-data-classification-for-human-activity-recognition-based-on-an-iterative-learning-framework
#11
Juan Carlos Davila, Ana-Maria Cretu, Marek Zaremba
The design of multiple human activity recognition applications in areas such as healthcare, sports and safety relies on wearable sensor technologies. However, when making decisions based on the data acquired by such sensors in practical situations, several factors related to sensor data alignment, data losses, and noise, among other experimental constraints, deteriorate data quality and model accuracy. To tackle these issues, this paper presents a data-driven iterative learning framework to classify human locomotion activities such as walk, stand, lie, and sit, extracted from the Opportunity dataset...
June 7, 2017: Sensors
https://www.readbyqxmd.com/read/28588062/secondary-somatic-mutations-restoring-rad51c-and-rad51d-associated-with-acquired-resistance-to-the-parp-inhibitor-rucaparib-in-high-grade-ovarian-carcinoma
#12
Olga Kondrashova, Minh Nguyen, Kristy Shield-Artin, Anna V Tinker, Nelson N H Teng, Maria I Harrell, Michael J Kuiper, Gwo-Yaw Ho, Holly Barker, Maria Jasin, Rohit Prakash, Elizabeth M Kass, Meghan R Sullivan, Gregory J Brunette, Kara A Bernstein, Robert L Coleman, Anne Floquet, Michael Friedlander, Ganessan Kichenadasse, David M O'Malley, Amit M Oza, James X Sun, Liliane Robillard, Lara Maloney, David D L Bowtell, Heidi Giordano, Matthew J Wakefield, Scott H Kaufmann, Andrew D Simmons, Thomas C Harding, Mitch Raponi, Iain A McNeish, Elizabeth M Swisher, Kevin Lin, Clare L Scott
High-grade epithelial ovarian carcinomas (OC) containing mutated BRCA1 or BRCA2 (BRCA1/2) homologous recombination (HR) genes are sensitive to platinum-based chemotherapy and poly(ADP-ribose) polymerase inhibitors (PARPi), while restoration of HR function due to secondary mutations in BRCA1/2 has been recognized as an important resistance mechanism. We sequenced core HR pathway genes in 12 pairs of pre-treatment and post-progression tumor biopsy samples collected from patients in ARIEL2 Part 1, a phase 2 study of the PARPi rucaparib as treatment for platinum-sensitive, relapsed OC...
June 6, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28587072/automatic-detection-of-driver-fatigue-using-driving-operation-information-for-transportation-safety
#13
Zuojin Li, Liukui Chen, Jun Peng, Ying Wu
Fatigued driving is a major cause of road accidents. For this reason, the method in this paper is based on the steering wheel angles (SWA) and yaw angles (YA) information under real driving conditions to detect drivers' fatigue levels. It analyzes the operation features of SWA and YA under different fatigue statuses, then calculates the approximate entropy (ApEn) features of a short sliding window on time series. Using the nonlinear feature construction theory of dynamic time series, with the fatigue features as input, designs a "2-6-6-3" multi-level back propagation (BP) Neural Networks classifier to realize the fatigue detection...
May 25, 2017: Sensors
https://www.readbyqxmd.com/read/28558313/fertility-affects-asymmetry-detection-not-symmetry-preference-in-assessments-of-3d-facial-attractiveness
#14
Michael B Lewis
Consistent with theories from evolutionary psychology, facial symmetry correlates with attractiveness. Further, the preference for symmetrical faces appears to be affected by fertility in women. One limitation of previous research is that faces are often symmetrically lit front-views and so symmetry can be assessed using 2D pictorial information. Another limitation is that two-alternative-forced-choice (2afc) tasks are often used to assess symmetry preference and these cannot distinguish between differences in preference for symmetry and differences in ability of asymmetry detection...
May 27, 2017: Cognition
https://www.readbyqxmd.com/read/28555125/determinants-of-motion-sickness-in-tilting-trains-coriolis-cross-coupling-stimuli-and-tilt-delay
#15
Giovanni Bertolini, Meek Angela Durmaz, Kim Ferrari, Alexander Küffer, Charlotte Lambert, Dominik Straumann
Faster trains require tilting of the cars to counterbalance the centrifugal forces during curves. Motion sensitive passengers, however, complain of discomfort and overt motion sickness. A recent study comparing different control systems in a tilting train, suggested that the delay of car tilts relative to the curve of the track contributes to motion sickness. Other aspects of the motion stimuli, like the lateral accelerations and the car jitters, differed between the tested conditions and prevented a final conclusion on the role of tilt delay...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28546558/probing-the-roles-of-calcium-binding-sites-during-the-folding-of-human-peptidylarginine-deiminase-4
#16
Yi-Liang Liu, Chien-Yun Lee, Yu-Ni Huang, Hui-Yi Chen, Guang-Yaw Liu, Hui-Chih Hung
Our recent studies of peptidylarginine deiminase 4 (PAD4) demonstrate that its non-catalytic Ca(2+)-binding sites play a crucial role in the assembly of the correct geometry of the enzyme. Here, we examined the folding mechanism of PAD4 and the role of Ca(2+) ions in the folding pathway. Multiple mutations were introduced into the calcium-binding sites, and these mutants were termed the Ca1_site, Ca2_site, Ca3_site, Ca4_site and Ca5_site mutants. Our data indicate that during the unfolding process, the PAD4 dimer first dissociates into monomers, and the monomers then undergo a three-state denaturation process via an intermediate state formation...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28541643/genotype-specific-methylation-of-hpv-in-cervical-intraepithelial-neoplasia
#17
Yaw Wen Hsu, Rui Lan Huang, Po Hsuan Su, Yu Chih Chen, Hui Chen Wang, Chi Chun Liao, Hung Cheng Lai
OBJECTIVE: Hypermethylation of human papillomavirus (HPV) and host genes has been reported in cervical cancer. However, the degree of methylation of different HPV types relative to the severity of the cervical lesions remains controversial. Studies of the degree of methylation associated with the host gene and the HPV genome to the severity of cervical lesions are rare. We examined the association of methylation status between host genes and late gene 1 (L1) regions of HPV16, 18, 52, and 58 in cervical brushings...
July 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28534644/a-spectral-power-analysis-of-driving-behavior-changes-during-the-transition-from-non-distraction-to-distraction
#18
Yuan Wang, Shan Bao, Wenjun Du, Zhirui Ye, James R Sayer
OBJECTIVE: This paper investigated and compared frequency-domain and time-domain characteristics of drivers' behavior before and after the start of distracted driving. METHOD: Data from an existing naturalistic driving study were used. Fast Fourier transform (FFT) was applied for the frequency domain analysis to explore drivers' behavior pattern changes between non-distracted (pre-starting of visual-manual task) and distracted (post-starting of visual-manual task) driving periods...
May 23, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28523246/targeted-presurgical-decompensation-in-patients-with-yaw-dependent-facial-asymmetry
#19
Kyung-A Kim, Ji-Won Lee, Jeong-Ho Park, Byoung-Ho Kim, Hyo-Won Ahn, Su-Jung Kim
Facial asymmetry can be classified into the rolling-dominant type (R-type), translation-dominant type (T-type), yawing-dominant type (Y-type), and atypical type (A-type) based on the distorted skeletal components that cause canting, translation, and yawing of the maxilla and/or mandible. Each facial asymmetry type represents dentoalveolar compensations in three dimensions that correspond to the main skeletal discrepancies. To obtain sufficient surgical correction, it is necessary to analyze the main skeletal discrepancies contributing to the facial asymmetry and then the skeletal-dental relationships in the maxilla and mandible separately...
May 2017: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/28521964/there-is-variability-in-our-perception-of-the-standard-head-orientation
#20
G N Hughes, J Gateño, J D English, J F Teichgraeber, J J Xia
The purposes of this study were to determine: (1) whether an observer's perception of the correct anatomical alignment of the head changes with time, and (2) whether different observers agree on the correct anatomical alignment. To determine whether the perception of the correct anatomical alignment changes with time (intra-observer comparison), a group of 30 observers were asked to orient, into anatomical alignment, the three-dimensional (3D) head photograph of a normal man, on two separate occasions. To determine whether different observers agree on the correct anatomical alignment (inter-observer comparison), the observed orientations were compared...
May 15, 2017: International Journal of Oral and Maxillofacial Surgery
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