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https://www.readbyqxmd.com/read/28079824/inflammatory-myofibroblastic-tumors-of-the-pancreas-in-children-a-case-report-and-literature-review
#1
Hsien-Kuan Liu, Yung-Cheng Lin, Ming-Lun Yeh, Yaw-Sen Chen, Yu-Tsun Su, Ching-Chung Tsai
INTRODUCTION: Inflammatory myofibroblastic tumors are an uncommon neoplasm, which are very rarely located in the pancreas. Clinically and radiologically, this rare pancreatic tumor presents as an abdominal mass lesion that mimics other pancreatic tumors, and should therefore be considered in the differential diagnosis of pancreatic tumors. CLINICAL FINDINGS AND DIAGNOSIS: The 15-year-old boy complained of abdominal pain over the left upper quadrant with intermittent fever for 7 days...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28077737/new-diagnostics-for-yaws
#2
Christian Kositz, Robert Butcher, Michael Marks
No abstract text is available yet for this article.
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28077607/anatomy-of-mdm2-and-mdm4-in-evolution
#3
REVIEW
Ban Xiong Tan, Hoe Peng Liew, Joy S Chua, Farid J Ghadessy, Yaw Sing Tan, David P Lane, Cynthia R Coffill
Mouse double minute (Mdm) genes span an evolutionary timeframe from the ancient eukaryotic placozoa Trichoplax adhaerens to Homo sapiens, implying a significant and possibly conserved cellular role throughout history. Maintenance of DNA integrity and response to DNA damage involve many key regulatory pathways, including precise control over the tumour suppressor protein p53. In most vertebrates, degradation of p53 through proteasomal targeting is primarily mediated by heterodimers of Mdm2 and the Mdm2-related protein Mdm4 (also known as MdmX)...
January 10, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28074956/tunable-superapolar-lotus-to-rose-hierarchical-nanosurfaces-via-vertical-carbon-nanotubes-driven-electrohydrodynamic-lithography
#4
Chiara Busà, Jonathan James Stanley Rickard, Eugene Chun, Yaw Chong, Viroshan Navaratnam, Pola Goldberg Oppenheimer
The development of a robust, cost-effective, scalable and simple technique that enables the design and construction of well-controlled large area superhydrophobic surface structures which can be easily tuned from lotus-leaf to rose-petal state is essential to enable progress in realising the full applied potential of such surfaces. In this study, we introduce the tuneable carbon nanotubes-based electrohydrodynamic lithography (CNT-EHL) to fabricate unique multiscale structured cones and nanohair-like architectures with various periodicities and dimensions, successfully enabling surface energy minimization...
January 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28074603/supplementing-diet-with-manitoba-lingonberry-juice-reduces-kidney-ischemia-reperfusion-injury
#5
Cara K Isaak, Pengqi Wang, Suvira Prashar, Karmin O, Daniel C W Brown, Samir C Debnath, Yaw L Siow
BACKGROUND: Lingonberry (Vaccinium vitis-idaea L.) contains high levels of anthocyanins which are bioavailable in the kidney and may be protective against ischemia-reperfusion (IR)-induced acute kidney injury. This study investigated the effect of lingonberry juice on IR-induced stress-activated signaling pathway and inflammatory response in the kidney. RESULTS: Sprague-Dawley rats subjected to kidney IR had significantly impaired kidney function, with increased activation of the JNK signaling pathway and increased inflammatory response, measured using a multiplex panel containing an extensive array of inflammatory biomarkers...
January 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28072863/a-single-dose-oral-azithromycin-versus-intramuscular-benzathine-penicillin-for-the-treatment-of-yaws-a-randomized-non-inferiority-trial-in-ghana
#6
Cynthia Kwakye-Maclean, Nsiire Agana, John Gyapong, Priscilia Nortey, Yaw Adu-Sarkodie, Esther Aryee, Kingsley Asiedu, Roland Ballard, Fred Binka
BACKGROUND: Yaws is a treponemal infection that was almost eradicated fifty years ago; however, the disease has re-emerged in a number of countries including Ghana. A single-dose of intramuscular benzathine penicillin has been the mainstay of treatment for yaws. However, intramuscular injections are painful and pose safety and logistical constraints in the poor areas where yaws occurs. A single center randomized control trial (RCT) carried out in Papua New Guinea in 2012 demonstrated the efficacy of a single-dose of oral azithromycin for the treatment of yaws...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28071714/three-dimensional-surgical-simulation-improves-the-planning-for-correction-of-facial-prognathism-and-asymmetry-a-qualitative-and-quantitative-study
#7
Cheng-Ting Ho, Hsiu-Hsia Lin, Eric J W Liou, Lun-Jou Lo
Traditional planning method for orthognathic surgery has limitations of cephalometric analysis, especially for patients with asymmetry. The aim of this study was to assess surgical plan modification after 3-demensional (3D) simulation. The procedures were to perform traditional surgical planning, construction of 3D model for the initial surgical plan (P1), 3D model of altered surgical plan after simulation (P2), comparison between P1 and P2 models, surgical execution, and postoperative validation using superimposition and root-mean-square difference (RMSD) between postoperative 3D image and P2 simulation model...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28061905/epidemiology-of-mansonella-perstans-in-the-middle-belt-of-ghana
#8
Linda Batsa Debrah, Norman Nausch, Vera Serwaa Opoku, Wellington Owusu, Yusif Mubarik, Daniel Antwi Berko, Samuel Wanji, Laura E Layland, Achim Hoerauf, Marc Jacobsen, Alexander Yaw Debrah, Richard O Phillips
BACKGROUND: Mansonellosis was first reported in Ghana by Awadzi in the 1990s. Co-infections of Mansonella perstans have also been reported in a small cohort of patients with Buruli ulcer and their contacts. However, no study has assessed the exact prevalence of the disease in a larger study population. This study therefore aimed to find out the prevalence of M. perstans infection in some districts in Ghana and to determine the diversity of Culicoides that could be potential vectors for transmission...
January 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28056021/comparison-of-doxycycline-minocycline-doxycycline-plus-albendazole-and-albendazole-alone-in-their-efficacy-against-onchocerciasis-in-a-randomized-open-label-pilot-trial
#9
Ute Klarmann-Schulz, Sabine Specht, Alexander Yaw Debrah, Linda Batsa, Nana Kwame Ayisi-Boateng, Jubin Osei-Mensah, Yusif Mubarik, Peter Konadu, Arcangelo Ricchiuto, Rolf Fimmers, Sandra Arriens, Bettina Dubben, Louise Ford, Mark Taylor, Achim Hoerauf
: The search for new macrofilaricidal drugs against onchocerciasis that can be administered in shorter regimens than required for doxycycline (DOX, 200mg/d given for 4-6 weeks), identified minocycline (MIN) with superior efficacy to DOX. Further reduction in the treatment regimen may be achieved with co-administration with standard anti-filarial drugs. Therefore a randomized, open-label, pilot trial was carried out in an area in Ghana endemic for onchocerciasis, comprising 5 different regimens: the standard regimen DOX 200mg/d for 4 weeks (DOX 4w, N = 33), the experimental regimens MIN 200mg/d for 3 weeks (MIN 3w; N = 30), DOX 200mg/d for 3 weeks plus albendazole (ALB) 800mg/d for 3 days (DOX 3w + ALB 3d, N = 32), DOX 200mg/d for 3 weeks (DOX 3w, N = 31) and ALB 800mg for 3 days (ALB 3d, N = 30)...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28048116/su-f-j-142-proposed-method-to-broaden-inclusion-potential-of-patients-able-to-use-the-calypso-tracking-system-in-prostate-radiotherapy
#10
D Fiedler, H Kuo, W Bodner, W Tome
PURPOSE: To introduce a non-standard method of patient setup, using BellyBoard immobilization, to better utilize the localization and tracking potential of an RF-beacon system with EBRT for prostate cancer. METHODS: An RF-beacon phantom was imaged using a wide bore CT scanner, both in a standard level position and with a known rotation (4° pitch and 7.5° yaw). A commercial treatment planning system (TPS) was used to determine positional coordinates of each beacon, and the centroid of the three beacons for both setups...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047555/su-g-jep4-14-assessment-of-inter-and-intra-fractional-motion-for-extremity-soft-tissue-sarcoma-patients-by-using-in-house-real-time-optical-image-based-monitoring-system
#11
H Kim, I Kim, S Ye
PURPOSE: This study aimed to assess inter- and intra-fractional motion for extremity Soft Tissue Sarcoma (STS) patients, by using in-house real-time optical image-based monitoring system (ROIMS) with infra-red (IR) external markers. METHODS: Inter- and intra-fractional motions for five extremity (1 upper, 4 lower) STS patients received postoperative 3D conformal radiotherapy (3D-CRT) were measured by registering the image acquired by ROIMS with the planning CT image (REG_ROIMS)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047382/mo-fg-campus-tep1-02-facial-recognition-and-recall-using-kinect-v2-for-patient-verification
#12
E Silverstein, M Snyder
PURPOSE: Investigate capability and accuracy of the Kinect v2 camera for facial recognition to use as a tool for patient check-in upon arrival, as well as patient verification when entering treatment vault. METHODS: The Kinect software has a native facial recognition feature which recognizes major facial landmarks (eyes, nose, mouth, etc). 1347 facial vertices are automatically generated, each located at a specific facial point at standardized distances between points...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047362/su-f-j-24-setup-uncertainty-and-margin-of-the-exactrac-6d-image-guide-system-for-patients-with-brain-tumors
#13
S Kim, S Oh, J Yea, J Park
PURPOSE: This study evaluated the setup uncertainties for brain sites when using BrainLAB's ExacTrac X-ray 6D system for daily pretreatment to determine the optimal planning target volume (PTV) margin. METHODS: Between August 2012 and April 2015, 28 patients with brain tumors were treated by daily image-guided radiotherapy using the BrainLAB ExacTrac 6D image guidance system of the Novalis-Tx linear accelerator. DUONTM (Orfit Industries, Wijnegem, Belgium) masks were used to fix the head...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047178/th-ab-202-12-the-first-clinical-implementation-of-a-real-time-six-degree-of-freedom-tracking-system-during-radiation-therapy
#14
D Nguyen, J Kim, R O'Brien, C Huang, J Booth, P Greer, K Legge, P Poulsen, J Martin, P Keall
PURPOSE: In current practice, imaging is typically performed prior to treatment; the cancer target motion during treatment is unknown. We present the first clinical implementation of real time Kilovoltage Intrafraction Monitoring (KIM) system which tracks the cancer target translational and rotational motions during treatment. METHODS: KIM technology: KIM estimates the 3D position of the target tumour based on segmented 2D positions of the three implanted fiducials in each of the kV images (125 kV, 10 mA at 11 fps) taken continuously during the treatment arc...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046735/su-f-j-47-inherent-uncertainty-in-the-positional-shifts-determined-by-a-volumetric-cone-beam-imaging-system
#15
U Giri, T Ganesh, V Saini, A Munshi, B Sarkar, B Mohanti
PURPOSE: To quantify inherent uncertainty associated with a volumetric imaging system in its determination of positional shifts. METHODS: The study was performed on an Elekta Axesse™ linac's XVI cone beam computed tomography (CBCT) system. A CT image data set of a Penta- Guide phantom was used as reference image by placing isocenter at the center of the phantom.The phantom was placed arbitrarily on the couch close to isocenter and CBCT images were obtained. The CBCT dataset was matched with the reference image using XVI software and the shifts were determined in 6-dimensions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046558/su-f-t-484-initial-evaluation-of-a-novel-6d-qa-phantom-hexacheck-for-daily-6d-couch-correction-assessment
#16
J E Roring, D Stanley, N Papanikolaou, A N Gutierrez
PURPOSE: Treatment couches with 6D correction capabilities have become a regular part of IGRT. While 6D couches have been shown to function mechanically well, phantoms for daily angular QA accuracy assessment have yet to be commercially available. Standard Imaging™ has developed a phantom designed for daily verification of pitch, roll, and yaw corrections. In this study, the mechanical integrity, reproducibility, and daily 6D correction stability of the phantom using both volumetric (Elekta- XVI kV-CBCT) and orthogonal kV (Brainlab ExacTrac) imaging was evaluated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046129/isolation-culture-and-characterization-of-hirsutella-sinensis-mycelium-from-caterpillar-fungus-fruiting-body
#17
Yun-Fei Ko, Jian-Ching Liau, Chien-Sheng Lee, Chen-Yaw Chiu, Jan Martel, Chuan-Sheng Lin, Shun-Fu Tseng, David M Ojcius, Chia-Chen Lu, Hsin-Chih Lai, John D Young
The caterpillar fungus Ophiocordyceps sinensis (previously called Cordyceps sinensis) has been used for centuries in Asia as a tonic to improve health and longevity. Recent studies show that O. sinensis produces a wide range of biological effects on cells, laboratory animals and humans, including anti-fatigue, anti-infection, anti-inflammatory, antioxidant, and anti-tumor activities. In view of the rarity of O. sinensis fruiting bodies in nature, cultivation of its anamorph mycelium represents a useful alternative for large-scale production...
2017: PloS One
https://www.readbyqxmd.com/read/28041715/evaluating-the-effectiveness-of-different-beta-adrenoceptor-blockers-in-heart-failure-patients
#18
Tien-Yu Lin, Chung-Yu Chen, Yaw-Bin Huang
BACKGROUND: According to guidelines and pivotal trials, β-blockers are associated with better survival in patients with heart failure (HF). However, the superiority of any β-blockers is still unclear. METHODS: This retrospective cohort study was conducted using the National Health Insurance Research Database in Taiwan to evaluate the effectiveness of β-blockers and compare the clinical outcomes of different β-blockers in patients with HF. We enrolled patients diagnosed with HF between 2005 and 2012...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28041317/stereotactic-radiosurgery-for-intradural-spine-tumors-using-cone-beam-ct-image-guidance
#19
Andrés Monserrate, Benjamin Zussman, Alp Ozpinar, Ajay Niranjan, John C Flickinger, Peter C Gerszten
OBJECTIVE Cone-beam CT (CBCT) image guidance technology has been widely adopted for spine radiosurgery delivery. There is relatively little experience with spine radiosurgery for intradural tumors using CBCT image guidance. This study prospectively evaluated a series of intradural spine tumors treated with radiosurgery. Patient setup accuracy for spine radiosurgery delivery using CBCT image guidance for intradural spine tumors was determined. METHODS Eighty-two patients with intradural tumors were treated and prospectively evaluated...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28038311/the-adhesion-circle-a-new-approach-to-better-characterize-directional-gecko-inspired-dry-adhesives
#20
Yue Wang, Samuel Lehmann, Jinyou Shao, Dan Sameoto
The number of different designs of directional gecko inspired adhesives has proliferated over the past 15 years, but some basic characterization tools are still non-standardized, which can make direct comparisons of different adhesives in the literature difficult. By far the most common type of test for directional adhesives, the Load-Drag-Pull (LDP) test is useful but can miss substantial information on the exact behavior of gecko-inspired adhesives in a variety of loading conditions. Other test techniques, including angled approaches and pull-offs have been employed by a few groups but they are not as widely adopted; peel tests can be employed but require a larger amount of adhesive material to use in the test, which is not always practical given some current manufacturing constraints...
December 30, 2016: ACS Applied Materials & Interfaces
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