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https://www.readbyqxmd.com/read/28197917/sumo-in-drosophila-development
#1
Joseph Cao, Albert J Courey
The ubiquitin -like protein SUMO is conjugated covalently to hundreds of target proteins in organisms throughout the eukaryotic domain. Genetic and biochemical studies using the model organism Drosophila melanogaster are beginning to reveal many essential functions for SUMO in cell biology and development. For example, SUMO regulates multiple signaling pathways such as the Ras/MAPK, Dpp, and JNK pathways. In addition, SUMO regulates transcription through conjugation to many transcriptional regulatory proteins, including Bicoid, Spalt , Scm, and Groucho...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28197279/a-sudden-change-of-heart-a-case-of-rapidly-reversed-stress-cardiomyopathy-in-a-critically-ill-patient
#2
Michael I Brener, Ali R Keramati, Marek A Mirski, Oscar H Cingolani
We report the case of a 79-year-old woman who presented to our hospital for elective removal of an infratentorial meningioma and suffered a periprocedural cardiac arrest. Shortly after uncomplicated induction of anesthesia prior to the surgery, the patient became hypotensive and bradycardic, culminating ultimately in a cardiac arrest with pulseless electrical activity. Return of spontaneous circulation occurred within 90 seconds of arrest, but the patient remained dependent on maximal doses of epinephrine and dopamine for hemodynamic support...
June 2016: Cardiology Research
https://www.readbyqxmd.com/read/28190955/multi-level-correlates-of-safer-conception-methods-awareness-and-attitudes-among-ugandan-hiv-clients-with-fertility-intentions
#3
Glenn J Wagner, Mahlet A Woldetsadik, Jolly Beyeza-Kashesya, Kathy Goggin, Deborah Mindry, Sarah Finocchario-Kessler, Sarah Khanakwa, Rhoda K Wanyenze
Many people living with HIV desire childbearing, but low cost safer conception methods (SCM) such as timed unprotected intercourse (TUI) and manual self-insemination (MSI) are rarely used. We examined awareness and attitudes towards SCM, and the correlates of these constructs among 400 HIV clients with fertility intentions in Uganda. Measures included awareness, self-efficacy, and motivation regarding SCM, as well as demographics, health management, partner and provider characteristics. Just over half knew that MSI (53%) and TUI (51%) reduced transmission risk during conception, and 15% knew of sperm washing and pre-exposure prophylaxis...
March 2016: African Journal of Reproductive Health
https://www.readbyqxmd.com/read/28180088/human-case-of-bacteremia-caused-by-streptococcus-canis-sequence-type-9-harboring-the-scm-gene
#4
Daisuke Taniyama, Yoshihiko Abe, Tetsuya Sakai, Takahide Kikuchi, Takashi Takahashi
Streptococcus canis (Sc) is a zoonotic pathogen that is transferred mainly from companion animals to humans. One of the major virulence factors in Sc is the M-like protein encoded by the scm gene, which is involved in anti-phagocytic activities, as well as the recruitment of plasminogen to the bacterial surface in cooperation with enolase, and the consequent enhancement of bacterial transmigration and survival. This is the first reported human case of uncomplicated bacteremia following a dog bite, caused by Streptococcus canis harboring the scm gene...
2017: IDCases
https://www.readbyqxmd.com/read/28178161/longitudinal-follow-up-of-muscle-echotexture-in-infants-with-congenital-muscular-torticollis
#5
Ching-Fang Hu, Tieh-Cheng Fu, Chung-Yao Chen, Carl Pai-Chu Chen, Yu-Ju Lin, Chih-Chin Hsu
Unilateral fibrous contracture of the sternocleidomastoid (SCM) muscle is the major pathophysiology in infants with congenital muscular torticollis (CMT). Physical examination is not always sufficient to detect minimal muscle fibrosis in involved SCM muscles.A prospective study for SCM muscle fibrosis in CMT infants by quantifying echotexture and muscle thickness during the course of treatment is highlighted in the study.Convenience samples of 21 female and 29 male infants with CMT, who were 1 to 12 months old, underwent physiotherapy for at least 3 months and were followed for 4...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28177526/segregated-fronto-cortical-and-midbrain-connections-in-the-mouse-and-their-relation-to-approach-and-avoidance-orienting-behaviors
#6
Michael Anthony Savage, Richard McQuade, Alexander Thiele
The orchestration of orienting behaviors requires the interaction of many cortical and subcortical areas, for example the Superior Colliculus (SC), as well as prefrontal areas responsible for top-down control. Orienting involves different behaviors, such as approach and avoidance. In the rat, these behaviors are at least partially mapped onto different SC subdomains, the lateral (SCl) and medial (SCm), respectively. To delineate the circuitry involved in the two types of orienting behavior in mice, we injected retrograde tracer into the intermediate and deep layers of the medial and lateral SC (SCm and SCl), and thereby determined the main input structures to these subdomains...
February 8, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28177166/splenius-capitis-is-a-reliable-target-for-measuring-cervical-vestibular-evoked-myogenic-potentials-in-adults
#7
A J Camp, C Gu, S L Cushing, K A Gordon, B D Corneil
The cervical vestibular evoked myogenic potential (cVEMP) is a common and simple test of vestibulospinal reflex patency. In the clinic, cVEMPs are measured in response to loud sounds from the sternocleidomastoid (SCM) on the ventral neck, as subjects maintain an uncomfortable head posture needed to recruit SCM. Here we characterize the cVEMP in a dorsal neck turner (Splenius Capitis; SPL), and compare it with the SCM cVEMP. cVEMPs were recorded simultaneously via surface electromyography from SCM and SPL from 17 healthy subjects in a variety of postures, including head-turned postures adopted while either seated or standing, and the clinical posture...
February 8, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28152597/gc-ms-metabolomics-identifies-metabolite-alterations-that-precede-subclinical-mastitis-in-the-blood-of-transition-dairy-cows
#8
Elda Dervishi, Guanshi Zhang, Suzanna M Dunn, Rupasri Mandal, David S Wishart, Burim N Ametaj
The objectives of this study were to determine alterations in the serum metabolites related to amino acid (AA), carbohydrate, and lipid metabolism in transition dairy cows before diagnosis of subclinical mastitis (SCM), during, and after diagnosis of disease. A subclinical mastitis case was determined as a cow having somatic cell count (SCC) > 200 000/mL of milk for two or more consecutive reports. Blood samples were collected from 100 Holstein dairy cows at five time points at -8 and -4 weeks before parturition, at the week of SCM diagnosis, and +4 and +8 weeks after parturition...
February 3, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28113976/hash-based-line-by-line-template-matching-for-lossless-screen-image-coding
#9
Xiulian Peng, Jizheng Xu
Template matching (TM) was proposed in literature a decade ago to efficiently remove non-local redundancies within an image without transmitting any overhead of displacement vectors. However, the large computational complexity introduced at both the encoder and the decoder, especially for a large search range, limits its widespread use. This paper proposes a hashbased line-by-line template matching (hLTM) for lossless screen image coding, where the non-local redundancy commonly exists in text and graphics parts...
September 22, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28113399/a-spatial-compositional-model-for-linear-unmixing-and-endmember-uncertainty-estimation
#10
Yuan Zhou, Anand Rangarajan, Paul D Gader
The normal compositional model (NCM) has been extensively used in hyperspectral unmixing. However, previous research has mostly focused on estimation of endmembers and/or their variability, based on the assumption that the pixels are independent random variables. In this paper, we show that this assumption does not hold if all the pixels are generated by a fixed endmember set. This introduces another concept, endmember uncertainty, which is related to whether the pixels fit into the endmember simplex. To further develop this idea, we derive the NCM from the ground up without the pixel independence assumption, along with (i) using different noise levels at different wavelengths and (ii) using a spatial and sparsity promoting prior for the abundances...
October 18, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28113021/fentanyl-sublingual-tablets-versus-subcutaneous-morphine-for-the-management-of-severe-cancer-pain-episodes-in-patients-receiving-opioid-treatment-a-double-blind-randomized-noninferiority-trial
#11
Ernesto Zecca, Cinzia Brunelli, Fabio Centurioni, Andrea Manzoni, Alessandra Pigni, Augusto Caraceni
Purpose Fentanyl sublingual tablets (FST) are a potentially useful alternative to parenteral opioids such as subcutaneous morphine (SCM) to treat severe cancer pain episodes. No direct comparison between FST and SCM is available. The aim of this study was to test noninferiority of FST versus SCM during the first 30 min postadministration. Methods Patients receiving stable opioid therapy and experiencing a severe pain episode were randomly assigned to either 100 µg FST or 5 mg SCM in a double-blind, double-dummy trial...
January 23, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28104084/access-to-vagal-projections-via-cutaneous-electrical-stimulation-of-the-neck-fmri-evidence-in-healthy-humans
#12
Eleni Frangos, Barry R Komisaruk
BACKGROUND: Stimulation of the vagus nerve via implanted electrodes is currently used to treat refractory epilepsy and depression. Recently, a non-invasive approach to vagal stimulation has demonstrated similar beneficial effects, but it remains unclear whether these effects are mediated via activation of afferent vagal fibers. OBJECTIVE: The present study was designed to ascertain whether afferent vagal projections can be accessed non-invasively by transcutaneous electrical stimulation of the antero-lateral surface of the neck, which overlies the course of the vagus nerve...
January 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28098196/enhanced-removal-of-as-v-from-aqueous-solution-using-modified-hydrous-ferric-oxide-nanoparticles
#13
Lijuan Huo, Xibai Zeng, Shiming Su, Lingyu Bai, Yanan Wang
Hydrous ferric oxide (HFO) is most effective with high treatment capacity on arsenate [As(V)] sorption although its transformation and aggregation nature need further improvement. Here, HFO nanoparticles with carboxymethyl cellulose (CMC) or starch as modifier was synthesized for the purpose of stability improvement and As(V) removal from water. Comparatively, CMC might be the optimum stabilizer for HFO nanoparticles because of more effective physical and chemical stability. The large-pore structure, high surface specific area, and the non-aggregated nature of CMC-HFO lead to increased adsorption sites, and thus high adsorption capacities of As(V) without pre-treatment (355 mg·g(-1)), which is much greater than those reported in previous studies...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28098180/an-aposymbiotic-primary-coral-polyp-counteracts-acidification-by-active-ph-regulation
#14
Yoshikazu Ohno, Akira Iguchi, Chuya Shinzato, Mayuri Inoue, Atsushi Suzuki, Kazuhiko Sakai, Takashi Nakamura
Corals build their skeletons using extracellular calcifying fluid located in the tissue-skeleton interface. However, the mechanism by which corals control the transport of calcium and other ions from seawater and the mechanism of constant alkalization of calcifying fluid are largely unknown. To address these questions, we performed direct pH imaging at calcification sites (subcalicoblastic medium, SCM) to visualize active pH upregulation in live aposymbiotic primary coral polyps treated with HCl-acidified seawater...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28096610/investigation-of-body-and-udder-skin-surface-temperature-differentials-as-an-early-indicator-of-mastitis-in-holstein-friesian-crossbred-cows-using-digital-infrared-thermography-technique
#15
M Sathiyabarathi, S Jeyakumar, A Manimaran, Heartwin A Pushpadass, M Sivaram, K P Ramesha, D N Das, Mukund A Kataktalware, G Jayaprakash, Tapas Kumar Patbandha
AIM: The objective of this study was to investigate the ability of infrared thermography (IRT) technique and its interrelationship with conventional mastitis indicators for the early detection of mastitis in Holstein Friesian (HF) crossbred cows. MATERIALS AND METHODS: A total of 76 quarters of lactating HF crossbred (Bos indicus × Bos taurus) cows (n=19) were monitored for body temperature (i.e., eye temperature) and udder skin surface temperature (USST) before milking using forward-looking infrared (FLIR) i5 camera...
December 2016: Veterinary World
https://www.readbyqxmd.com/read/28077757/biotypes-and-scm-types-of-isolates-of-streptococcus-canis-from-diseased-and-healthy-cats
#16
J F Timoney, S Velineni, B Ulrich, P Blanchard
Lancefield group G Streptococcus canis is a component of the normal urogenital and pharyngeal flora of the cat. It is also frequently implicated in epizootics of severe disease in closed cat colonies and animal shelters. Given the importance of S canis as a feline pathogen and relative lack of published information on characteristics potentially associated with virulence, the authors have compared isolates from healthy and diseased cats in New York and California using fermentation profiles (biotype) and ScM sequences...
January 11, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28074202/an-ising-iron-ii-chain-exhibits-a-large-finite-size-energy-barrier-and-hard-magnetic-behaviour
#17
Yi-Fei Deng, Tian Han, Wei Xue, Naoaki Hayashi, Hiroshi Kageyama, Yan-Zhen Zheng
One-dimensional spin chains featuring strong axial anisotropic magnetism are promising candidates for isolatable and miniatured information storage materials, the so-called single-chain magnets (SCMs). Here we show a mixed azido/carboxylato bridged metamagnetic iron(ii) chain [Fe(N3)2(4-mpc)]n (4-mpc = N-methylpyridinium-4-carboxylate) with a large energy barrier of 150 K, a large remnant magnetization (1.55Nβ) and coercivity (1.7 T at 2 K) for homo-spin SCMs. Heat capacity and Mössbauer spectroscopy studies corroborate the intrinsic nature of SCM behavior regardless of weak interchain magnetic interactions, which lead to the coexistence of metamagnetism but not long-range magnetic ordering...
January 11, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28064009/targeted-sustained-delivery-of-antineoplastic-agent-with-multicomponent-polylactide-stereocomplex-micelle
#18
Kexin Shen, Di Li, Jingjing Guan, Jianxun Ding, Zhongtang Wang, Jingkai Gu, Tongjun Liu, Xuesi Chen
A c(RGDfC)-decorated polylactide stereocomplex micelle (cRGD-SCM) was prepared through the stereocomplex and hydrophobic interactions among 4-arm poly(ethylene glycol)-block-poly(D-lactide) (4-arm PEG-b-PDLA), methoxy poly(ethylene glycol)-block-poly(L-lactide) (mPEG-b-PLLA), and c(RGDfC)-poly(ethylene glycol)-block-poly(L-lactide) (cRGD-PEG-b-PLLA) for targeted treatment of αvβ3 integrin-positive C26 colon cancer. Doxorubicin (DOX), a model antitumor drug, was loaded into cRGD-SCM with a diameter of approximately 100nm, and the drug loading efficiency was 45...
January 5, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28061496/adult-patients-with-congenital-muscular-torticollis-treated-with-bipolar-release-report-of-31-cases
#19
Gun Sang Lee, Myung Ki Lee, Woo Jae Kim, Ho Sang Kim, Jeong Ho Kim, Yun-Suk Kim
OBJECTIVE: We assessed the surgical results of bipolar release in 31 adult patients with uncorrected congenital muscular torticollis (CMT) and more than 12 months of follow-up. METHODS: Thirty-one patients underwent a bipolar release of the sternocleidomastoid muscle (SCM) and were retrospectively analyzed. The mean follow-up period was 14.9 months (range, 12-30). The mean age at time of surgery was 30.3 years (range, 20-54). Patients were evaluated with a modified Lee's scoring system, cervicomandibular angle (CMA) measurement, and a global satisfaction rating scale using patient self-reporting...
January 1, 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28046339/su-f-p-51-similarity-analysis-of-the-linear-accelerator-machines-based-on-clinical-simulation
#20
K Li
PURPOSE: To evaluate the clinical rationale for Truebeam and Trilogy Linac machines from Varian Medical System as exchangeable treatment modalities in the same radiation oncology department. METHODS: Intensity Modulated Radiotherapy (IMRT) plans for different diseases were selected for this study. These disease sites included brain, head and neck, breast, lung, and prostate. The parameters selected for this study were the energy amount, Monitor Unit (MU); dose coverage of target reflected by prescription isodose volume(PIV); dose spillage described by the volume of 50% isodoseline of the prescription; and dose homogeneities represented by the maximum dose (MaxD) and the minimum dose (MinD) of target volume (TV) and critical structure (CS)...
June 2016: Medical Physics
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