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https://www.readbyqxmd.com/read/28528863/cross-linking-of-a-biopolymer-peptide-co-assembling-system
#1
Karla E Inostroza-Brito, Estelle C Collin, Anna Poliniewicz, Sherif Elsharkawy, Alistair Rice, Armando E Del Río Hernández, Xin Xiao, José Rodríguez-Cabello, Alvaro Mata
The ability to guide molecular self-assembly at the nanoscale into complex macroscopic structures could enable the development of functional synthetic materials that exhibit properties of natural tissues such as hierarchy, adaptability, and self-healing. However, the stability and structural integrity of these kinds of materials remains a challenge for many practical applications. We have recently developed a dynamic biopolymer-peptide co-assembly system with the capacity to grow and undergo morphogenesis into complex shapes...
May 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28510427/single-crystal-proton-conduction-study-of-a-metal-organic-framework-of-modest-water-stability
#2
Jian-Bin Lin, Zaida Romero, George K H Shimizu, Biplab Joarder
A sulfonated indium (In) metal organic framework (MOF) is reported with an anionic layered structure incorporating hydrogen bonded dimethylammonium cations and water molecules. The MOF becomes amorphous in >60% relative humidity, however, impedance analysis of pelletized powders revealed a proton conduction value of over 10-3 S cm-1 at 25 °C and 40% RH, a very high proton conduction value for low humidity and moderate temperature. Given the modest humidity stability of the MOF, triaxial impedance analyses on a single crystal was performed and confirmed bulk proton conductivity over 10-3 Scm-1 along two axes corroborating the data from the pellet...
May 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28508179/sternocleidomastoid-flap-augmentation-of-the-pharyngeal-closure-after-total-laryngectomy
#3
Sherif Gabr Ibrahim, Basim Metwally Wahba, Ahmed Mahmoud Elbatawi, Ahmad Mohamed Eltelety
The objective of the study was to evaluate the effect of sternocleidomastoid (SCM) flap augmentation of the pharyngeal closure after total laryngectomy on the incidence of pharyngocutaneous fistula (PCF). Thirty patients with T4a laryngeal carcinoma and none of them receiving primary radiotherapy previously were divided into two equal groups. Group A patients had SCM flap augmentation of the pharyngeal closure after total laryngectomy. Group B patients had the standard pharyngeal closure without augmentation...
May 15, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28502172/direct-dopant-patterning-by-remote-monolayer-doping-enabled-by-monolayer-fragmentation-study
#4
Ori Hazut, Roie Yerushalmi
The development of new doping methods extending beyond the traditional and well-established techniques is desired to match the rapid advances made in semiconductor processing methods and nanostructure synthesis in numerous emerging applications, including the doping of 3D architectures. To address this, monolayer doping (MLD) and monolayer contact doping (MLCD) methods were recently introduced. The monolayer doping methods enable separation of the doping process of nanostructures from the synthesis step, hence it is also termed ex-situ doping...
May 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28499964/life-history-dependent-relationships-between-body-condition-and-immunity-between-immunity-indices-in-male-eurasian-tree-sparrows
#5
Yuliang Zhao, Mo Li, Yanfeng Sun, Wei Wu, Guanqun Kou, Lingling Guo, Danning Xing, Yuefeng Wu, Dongming Li, Baohua Zhao
In free-living animals, recent evidence indicates that innate, and acquired, immunity varies with annual variation in the demand for, and availability of, food resources. However, little is known about how animals adjust the relationships between immunity and body condition, and between innate and acquired immunity to optimize survival over winter and reproductive success during the breeding stage. Here, we measured indices of body condition (size-corrected mass [SCM], and hematocrit [Hct]), constitutive innate immunity (plasma total complement hemolysis activity [CH50]) and acquired immunity (plasma immunoglobulin A [IgA]), plus heterophil/lymphocyte (H/L) ratios, in male Eurasian tree sparrows (Passer montanus) during the wintering and the breeding stages...
May 9, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28489314/unclassifiable-pattern-of-hypopigmentation-in-a-patient-with-mosaic-partial-12p-tetrasomy-without-pallister-killian-syndrome
#6
Viola Alesi, Maria L Dentici, Fabrizia Restaldi, Valeria Orlando, Maria T Liambo, Chiara Calacci, Rossella Capolino, Maria C Digilio, May El Hachem, Antonio Novelli, Andrea Diociaiuti, Bruno Dallapiccola
Pallister-Killian syndrome (PKS-#OMIM601803) is a multisystem developmental disorder typically due to the presence of an aneuploidy cell line, consisting of a supernumerary tetrasomic chromosomal marker (SCM) arisen from the short arm of chromosome 12 (12p isochromosome). The clinical phenotype, which is strictly related to the percentage and tissue distribution of aneuploid cells, is characterized by craniofacial dysmorphisms, pigmentary skin anomalies, limb shortening, congenital heart defects, diaphragmatic hernia, hypotonia, intellectual disability, and epilepsy...
May 10, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28484560/a-unique-case-of-split-cord-malformation-type-1-with-three-different-types-of-bony-spurs
#7
Kanwaljeet Garg, Vivek Tandon, Ashok Kumar Mahapatra
Split cord malformation (SCM) is a rare congenital anomaly. The presence of bony spurs seen in type 1 SCM are usually partial and unequivocally are found attached to the dorsal surface of the vertebral body. We present here a unique case of SCM where the bony spur was found attached to the ventral aspect of the posterior arch and there were three different types of spurs (Type 1A, 1B and 1C) in the same patient.
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28474340/doddering-but-dear-%C3%A2-even-in-the-eyes-of-young-children-age-stereotyping-and-prejudice-in-childhood-and-adolescence
#8
Christin-Melanie Vauclair, Ricardo Borges Rodrigues, Sibila Marques, Carla Sofia Esteves, Filipa Cunha, Filomena Gerardo
This study aims to explore age prejudice, and to examine age stereotyping in children and adolescents by adopting the Stereotype Content Model (SCM) as a theoretical framework. It was hypothesised that children are socialised into adopting an ambivalent representation of old age (socialisation hypothesis) and that this cognitive bias becomes weaker in adolescence due to greater cognitive maturity (developmental hypothesis). By analysing representative data from Portugal (European Social Survey; N = 2367), it was ascertained that the ambivalent age stereotype (higher evaluations of warmth than competence for older people) is indeed a shared social representation of older people in Portuguese society...
May 5, 2017: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/28472950/senescence-associated-il-6-and-il-8-cytokines-induce-a-self-and-cross-reinforced-senescence-inflammatory-milieu-strengthening-tumorigenic-capabilities-in-the-mcf-7-breast-cancer-cell-line
#9
Paola Ortiz-Montero, Arturo Londoño-Vallejo, Jean-Paul Vernot
BACKGROUND: There is compelling evidence associating senescent cells with the malignant progression of tumours. Of all senescence-related mechanisms, the so-called senescence-associated secretory phenotype (SASP) has attracted much attention. Since the pro-inflammatory cytokines IL-6 and IL-8 are consistently present in the SASP, and secreted by highly aggressive breast cancer cell lines, we aimed at elucidating their role on the less aggressive breast cancer cell line MCF-7, which does not secret these cytokines...
May 4, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28471006/stepwise-construction-of-self-assembled-heterometallic-cages-showing-high-proton-conductivity
#10
Partha Sarathi Mukherjee, Rupak Saha, Dipak Samanta, Aninda Jiban Bhattacharyya
Two neutral tripodal metalloligands (CoL and FeL) containing a clathrochelate core were synthesized and characterized in one-step. Reactions of these ligands with three different metal acceptors cis-(tmen)Pd(NO3)2, Zn(NO3)2 and Mn(ClO4)2 separately yielded a series of hetero-metallic coordination cages (1a-3a and 1b-3b) in high yields. Depending on the nature of coordination geometry of the acceptors, resulting assemblies have trigonal-bipyramidal (1a/1b), open-cubic (2a/2b), and closed-cubic structures (3a/3b)...
May 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28469158/evaluating-the-utility-of-syndromic-case-management-for-three-sexually-transmitted-infections-in-women-visiting-hospitals-in-delhi-india
#11
Subash Chandra Sonkar, Kirti Wasnik, Anita Kumar, Vineeta Sharma, Pratima Mittal, Prashant Kumar Mishra, Mausumi Bharadwaj, Daman Saluja
Utility of syndromic case management (SCM) in women visiting obstetrics & gynecology department needs to be evaluated as it is subjective and imperfect. Consequently, antibiotic resistance has accelerated along with increased risk of infection to the partners. To understand the effectiveness and/or inadequacies of SCM, 11000 women were recruited and examined by clinicians for infection by Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV), Bacterial vaginosis (BV) and others...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28465132/comparison-of-cervical-muscle-thickness-between-asymptomatic-women-with-and-without-forward-head-posture
#12
Fateme Bokaee, Asghar Rezasoltani, Farideh D Manshadi, Sedigheh S Naimi, Alireza A Baghban, Hadi Azimi
BACKGROUND: Forward head posture (FHP) is a forward positioning of the head relative to the trunk in the sagittal plane. This posture is one of the most prevalent poor postures in patients with head and neck pain. Rehabilitative Ultrasound Imaging (RUSI) is a reliable method to objectively evaluate muscle thickness and function. OBJECTIVE: To compare thickness of cervical muscles that control both head and neck posture between asymptomatic women with and without FHP...
April 19, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28459581/ion-exchange-thermodynamics-at-the-rutile-water-interface-flow-microcalorimetric-measurements-and-surface-complexation-modeling-of-na-k-rb-cl-no3-adsorption
#13
Tyler Hawkins, Nicholas Allen, Michael L Machesky, David J Wesolowski, Nadine Kabengi
Flow microcalorimetry was used to investigate the energetics associated with Rb(+), K(+), Na(+), Cl(-), and NO3(-) exchange at the rutile-water interface. Heats of exchange reflected differences in bulk hydration/dehydration enthalpies (Na(+) > K(+) > Rb(+), and Cl(-) > NO3(-)) such that exchanging Na(+) or Cl(-) from the surface was exothermic, reflecting their greater bulk hydration enthalpies. Exchange heats were measured at pH 2, 3.25, 5.8, and 11 and exhibited considerable differences as well as pH dependence...
May 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28453447/correlation-between-forward-head-posture-respiratory-functions-and-respiratory-accessory-muscles-in-young-adults
#14
Mi-Sun Kim, Yong-Jun Cha, Jong-Duk Choi
BACKGROUND: Forward head posture (FHP) causes changes in the strengths and rigidities of cervical muscles. OBJECTIVE: The aim of this study was to investigate correlations between FHP and respiratory functions and the muscle activities of respiratory accessory muscles in young adults in their 20s. METHODS: A volunteer sample of 33 healthy young adults participated in this study. Craniovertebral angle (CVA), cranial rotational angle (CRA), vital capacity (VC), forced vital capacity (FVC), forced expiratory volume at 1 second (FEV1), peak expiratory flow (PEF), maximal voluntary ventilation (MVV), and sternocleidomastoid (SCM) and upper trapezius activity ratios were measured...
April 14, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28442176/mastitis-outcomes-on-pre-ovulatory-follicle-diameter-estradiol-concentrations-subsequent-luteal-profiles-and-conception-rate-in-buffaloes
#15
Mohamed Mohsen Mansour, Moustafa M Zeitoun, Fekry M Hussein
The objectives of this study was to investigate the outcome of mastitis, in its clinical or subclinical forms, on the mean diameter of pre-ovulatory follicle (POF), plasma estradiol concentration on the day of estrus, subsequent luteal profile and subsequent conception rate in buffaloes. Sixty dairy buffalo (Bubalus bubalus) conducted in this study were divided into three groups {healthy (H), n=20; subclinical mastitis (SCM), n=18; and clinical mastitis (CM), n=22}. Ultrasonography of ovaries revealed that mean diameter of POF was larger (P<0...
April 14, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28440698/therapeutic-peg-ceramide-nanomicelles-synergize-with-salinomycin-to-target-both-liver-cancer-cells-and-cancer-stem-cells
#16
Meiping Wang, Fangyuan Xie, Xikai Wen, Han Chen, Hai Zhang, Junjie Liu, He Zhang, Hao Zou, Yuan Yu, Yan Chen, Zhiguo Sun, Xinxia Wang, Guoqing Zhang, Chuan Yin, Duxin Sun, Jie Gao, Beige Jiang, Yanqiang Zhong, Ying Lu
AIM: Salinomycin (SAL)-loaded PEG-ceramide nanomicelles (SCM) were prepared to target both liver cancer cells and cancer stem cells. MATERIALS & METHODS: The synergistic ratio of SAL/PEG-ceramide was evaluated to prepare SCM, and the antitumor activity of SCM was examined both in vitro and in vivo. RESULTS: SAL/PEG-ceramide molar ratio of 1:4 was chosen as the synergistic ratio, and SCM showed superior cytotoxic effect and increased apoptosis-inducing activity in both liver cancer cells and cancer stem cells...
May 2017: Nanomedicine
https://www.readbyqxmd.com/read/28437279/npy-impairs-cell-viability-and-mitochondrial-membrane-potential-through-ca2-and-p38-signaling-pathways-in-neonatal-rat-cardiomyocytes
#17
Jun Hu, Xuehua Xu, Yuanyi Zuo, Xiangting Gao, Yun Wang, Cunquan Xiong, Hongcheng Zhou, Shaohua Zhu
NPY is involved in stress cardiomyopathy (SCM). However, the associated mechanism for NPY-induced SCM remains unclear. In this study, we aimed to explore potential cell signaling pathways that are related to NPY-mediated cell viability in neonatal rat cardiomyocytes. We found that NPY induced cell viability suppression in cultured cardiomyocytes in a dose-dependent manner. After NPY treatment, the expression of CaN and p-CAMKII was increased significantly, and the phosphorylation of p38 but not ERK and JNK was detected...
April 18, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28430937/high-sugar-but-not-high-fat-food-activates-supraoptic-oxytocin-neurones-in-the-male-rat
#18
Catherine Hume, Nancy Sabatier, John Menzies
Oxytocin is a potent anorexigen and is believed to have a role in satiety signalling. We developed rat models to study the activity of oxytocin neurones in response to voluntary consumption or oral gavage of foods using c-Fos immunohistochemistry and in vivo electrophysiology.Using c-Fos expression as an indirect marker of neural activation, we showed that the percentage of magnocellular oxytocin neurones expressing c-Fos increased with voluntary consumption of sweetened condensed milk (SCM). To model the effect of food in the stomach, we gavaged anaesthetised rats with SCM...
April 19, 2017: Endocrinology
https://www.readbyqxmd.com/read/28429809/successful-pegylation-of-hollow-encapsulin-nanoparticles-from-rhodococcus-erythropolis-n771-without-affecting-their-disassembly-and-reassembly-properties
#19
Seiichi Sonotaki, Taku Takami, Keiichi Noguchi, Masafumi Odaka, Masafumi Yohda, Yoshihiko Murakami
We developed a hollow PEGylated encapsulin nanoparticle from Rhodococcus erythropolis N771. The hollow engineered encapsulin nanoparticles with His-Tag and Lys residues on the surface were constructed by means of genetic recombination. The Lys residues on the particle surface were successfully PEGylated with a PEG derivative, methoxy-PEG-SCM. Consequently, we demonstrated that the hollow PEGylated engineered encapsulin nanoparticle could successfully disassemble or reassemble even after PEGylation in the presence or absence of a protein denaturing agent...
April 21, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28419949/characteristics-of-seizure-induced-signal-changes-on-mri-in-patients-with-first-seizures
#20
Si Eun Kim, Byung In Lee, Kyong Jin Shin, Sam Yeol Ha, JinSe Park, Kang Min Park, Hyung Chan Kim, Joonwon Lee, Soo-Young Bae, Dongah Lee, Sung Eun Kim
PURPOSE: The aim of this study was to investigate the predictive factors and identify the characteristics of the seizure-induced signal changes on MRI (SCM) in patients with first seizures. METHODS: We conducted a retrospective study of patients with first seizures from March 2010 to August 2014. The inclusion criteria for this study were patients with 1) first seizures, and 2) MRI and EEG performed within 24h of the first seizures. The definition of SCM was hyper-intensities in the brain not applying to cerebral arterial territories...
April 11, 2017: Seizure: the Journal of the British Epilepsy Association
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