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https://www.readbyqxmd.com/read/29222043/catheter-ablation-of-atrial-fibrillation-in-patients-with-heart-failure-and-preserved-ejection-fraction
#1
Eric Black-Maier, Xinru Ren, Benjamin A Steinberg, Cynthia L Green, Adam S Barnett, Normita Sta Rosa, Sana M Al-Khatib, Brett D Atwater, James P Daubert, Camille Frazier-Mills, Augustus O Grant, Donald D Hegland, Kevin P Jackson, Larry R Jackson, Jason I Koontz, Robert K Lewis, Albert Y Sun, Kevin L Thomas, Tristam D Bahnson, Jonathan P Piccini
BACKGROUND: Few studies have examined outcomes of catheter ablation for atrial fibrillation (AF) in patients with heart failure with preserved ejection fraction (HFpEF). OBJECTIVE: Compare outcomes of AF ablation in patients with HFpEF versus HF with reduced ejection fraction (HFrEF). METHODS: We performed a retrospective study of 230 patients with HF who underwent AF ablation, including 97 (42.2%) with HFrEF and 133 (57.8%) with HFpEF. Outcomes included adverse events, symptoms (Mayo AF Symptom Inventory [MAFSI]), New York Heart Association (NYHA) functional class, and freedom from recurrent atrial arrhythmia at 12-months...
December 5, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29221971/preventive-treatment-with-lomerizine-increases-cerebral-blood-flows-during-the-interictal-phase-of-migraine
#2
Ken Ikeda, Joe Aoyagi, Sayori Hanashiro, Masahiro Sawada, Maya Kyuzen, Harumi Morioka, Junya Ebina, Junpei Nagasawa, Masaru Yanagihashi, Yuichi Ishikawa, Ken Miura, Kiyoko Murata, Takanori Takazawa, Kiyokazu Kawabe, Yasuo Iwasaki
BACKGROUND: Changes in regional cerebral blood flow (rCBF) were reported in migraineurs. However, little is known how preventive medications of migraine can influence rCBF. Lomerizine, a calcium channel blocker, has been used for migraine prophylaxis in Japan. We examined rCBF after lomerizine treatment. SUBJECTS AND METHODS: Migraine was diagnosed according to the criteria of the International Classification of Headache Disorders, Third Edition beta. Migraine subtype was classified into migraine with aura (MA) and migraine without aura (MO)...
December 5, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29220885/indexes-of-the-erythropoietin-level-in-the-blood-plasma-of-chronic-heart-failure-patients-with-anemia
#3
Kamala Kh Zahidova
BACKGROUND: Anemia aggravates the disease course and the survival rate of chronic heart failure (CHF) patients. The purpose of the study was to investigate the level of erythropoietin (EPO) in CHF patients with anemic syndrome, with the aim to more accurately assess the severity of the disease and its treatment, depending on the anemia degree. METHODS: Patients with ischemic CHF of I-IV functional class (FC) with and without anemia were examined (total number of patients=208, patients with anemia=174)...
December 7, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29219824/thyrotoxic-periodic-paralysis-an-unusual-presentation-of-hyperthyroidism
#4
M Salih, C M J van Kinschot, R P Peeters, W W de Herder, E J J Duschek, J van der Linden, C van Noord
Thyrotoxic periodic paralysis (TPP) is a complication of hyperthyroidism among Asians, characterised by sudden onset of hypokalaemia and muscle paralysis. Several factors may contribute to a delay in diagnosis, including the subtlety of hyperthyroidism, the transient nature of the events and the rarity of this disease in the West. As life-threatening arrhythmias may occur during an attack, awareness among physicians is necessary for early recognition and treatment. Advances have been made in understanding the pathophysiological mechanism leading to hypokalaemia, which include recently identified mutations of the inwardly rectifying potassium channel Kir2...
October 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29218625/diuretic-or-beta-blocker-for-hypertensive-patients-already-receiving-acei-arb-and-calcium-channel-blocker
#5
Min-Shan Tsai, Chao-Hsiun Tang, Chia-Ying Lin, Po-Ya Chuang, Nai-Chuan Chen, Chien-Hua Huang, Wei-Tien Chang, Tzung-Dau Wang, Ping-Hsun Yu, Wen-Jone Chen
BACKGROUND: In patients already receiving combination of angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB) and calcium channel blocker (CCB), whether the choice of additional diuretic or beta-blocker affects the cardiovascular and cerebrovascular outcomes remains unclear. METHODS: A total of 13,551 patients who were concurrently receiving three anti-hypertensive agents of different classes through outpatient clinics during 2004-2006 were identified from the National Health Insurance Research Database of Taiwan...
December 8, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29218065/acute-myocardial-injury-in-a-child-with-duchenne-muscular-dystrophy-pulse-steroid-therapy
#6
Eliza Cinteza, Claudiu Stoicescu, Niculina Butoianu, Mihaela Balgradean, Alin Nicolescu, Matthias Angrés
Heart implication in Duchenne muscular dystrophy usually is present in the form of dilated cardiomyopathy, manifested as heart failure and arrhythmias. To delay progression, including heart deterioration, prednisone is recommended as preventive treatment. We report the case of an 11-year-old boy diagnosed with Duchenne muscular dystrophy at the age of seven, who was on preventive treatment with oral prednisone (0.75 mg/kg/day) and beta blocker (metoprolol, 1 mg/kg/day). Suddenly, the patient presented acute chest pain, vomiting and sweating...
September 2017: Mædica
https://www.readbyqxmd.com/read/29217463/electrical-storm-in-the-early-phase-of-heartmate%C3%A2-ii-device-implantation-incidence-risk-factors-and-prognosis
#7
Jerome Corre, François Picard, Rodrigue Garcia, Adlane Zemmoura, Nicolas Derval, Arnaud Denis, Antoine Romen, Karine Nubret, Pierre Jais, Michel Haissaguerre, Pierre Dos Santos, Laurent Barandon, Frederic Sacher
BACKGROUND: Ventricular arrhythmia is common after left ventricular assist device (LVAD) implantation, especially in the early postoperative phase (<30 days). AIM: To identify the incidence of and risk factors for electrical storm (ES) occurring within 30 days of HeartMate® II implantation. METHODS: We reviewed data from all consecutive patients undergoing HeartMate® II device implantation at our institution from January 2008 to December 2014...
December 4, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29216818/neuroprotective-effects-of-amiodarone-in-a-mouse-model-of-ischemic-stroke
#8
Masakazu Kotoda, Tadahiko Ishiyama, Kazuha Mitsui, Sohei Hishiyama, Takashi Matsukawa
BACKGROUND: Ion channels play a crucial role in the development of ischemic brain injury. Recent studies have reported that the blockade of various types of ion channels improves outcomes in experimental stroke models. Amiodarone, one of the most effective drugs for life-threatening arrhythmia, works as a multiple channel blocker and its characteristics cover all four Vaughan-Williams classes. Although it is known that amiodarone indirectly contributes to preventing ischemic stroke by maintaining sinus rhythm in patients with atrial fibrillation, the direct neuroprotective effect of amiodarone has not been clarified...
December 8, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/29214511/managing-gout-flares-in-the-elderly-practical-considerations
#9
Abhishek Abhishek
Gout is common in the elderly, affecting an estimated 4.7 million people aged > 60 years in the USA alone. The incidence and prevalence of gout increases, and male predisposition to gout reduces, with increasing age. The elderly have more comorbidities, and gout manifests differently, with more frequent involvement of knees, ankles, and wrists at disease onset, systemic upset, and tophi. Comorbidities and polypharmacy make the management of gout flares challenging in this population. Intra-articular corticosteroid injection remains the treatment of choice for accessible joints, oral prednisolone is preferred over low-dose colchicine, and non-steroidal anti-inflammatory drugs (NSAIDs) are best avoided...
December 6, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29214053/severe-carvedilol-toxicity-without-overdose-caution-in-cirrhosis
#10
Satish Maharaj, Karan Seegobin, Julio Perez-Downes, Belinda Bajric, Simone Chang, Pramod Reddy
Background: Carvedilol is used in the management of hypertension, ischemic heart disease, heart failure and most recently, portal hypertension. It has been associated with improved outcomes regarding variceal bleeding, hepatic decompensation and death when compared to propranolol and endoscopic band ligation. The main cause of portal hypertension is cirrhosis and therefore carvedilol is increasingly used in these patients. Due to its extensive hepatic metabolism, carvedilol is contraindicated in severe hepatic impairment...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/29210030/pharmacologic-prevention-of-variceal-bleeding-and-rebleeding
#11
REVIEW
Anna Baiges, Virginia Hernández-Gea, Jaime Bosch
BACKGROUND: Variceal bleeding is a major complication of portal hypertension, which is associated with significant mortality. Moreover, patients surviving a variceal bleeding episode have very high risk of rebleeding, which is associated with mortality as high as that of the first bleed. Because of this, prevention of bleeding from gastroesophageal varices has been one of the main therapeutic goals since the advent of the first effective therapies for portal hypertension. AIM: This review deals with the present day state-of-the-art pharmacological prevention of variceal bleeding in primary and secondary prophylaxis...
December 5, 2017: Hepatology International
https://www.readbyqxmd.com/read/29208420/the-inhibitor-of-connexin-cx36-channels-mefloquine-inhibits-voltage-dependent-ca2-channels-and-insulin-secretion
#12
Nele Seemann, Andrea Welling, Ingo Rustenbeck
The antimalarial agent, mefloquine, inhibits the function of connexin Cx36 gap junctions and hemichannels and has thus become a tool to investigate their physiological relevance in pancreatic islets. In view of earlier reports on a KATP channel-block by mefloquine, the specificity of mefloquine as a pharmacological tool was investigated. Mouse pancreatic islets and single beta cells were used to measure membrane potential, whole cell currents, Ca2+ channel activity, cytosolic Ca2+ concentration ([Ca2+]i) and insulin secretion...
December 2, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29206784/effect-of-beta-blocker-treatment-on-vo2peak-in-patients-with-heart-failure
#13
David Montero, Andreas J Flammer
PURPOSE: In addition to prolong life and reduce hospitalization rates, it is currently unclear whether beta-blocker (BB) treatment modulates peak oxygen consumption (VO2peak), a hallmark of exercise capacity, in patients with heart failure (HF). The main aim of this study is to determine the effect of BB treatment on VO2peak in HF patients. METHODS: We conducted a systematic search of MEDLINE, Scopus and Web of Science since their inceptions until March 2017 for randomized controlled trials (RCTs) assessing the effect of BB treatment on VO2peak in chronic HF patients...
December 2, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29204794/thoracic-aortic-aneurysm-unlocking-the-silent-killer-secrets
#14
Ayman A Saeyeldin, Camilo A Velasquez, Syed Usman B Mahmood, Adam J Brownstein, Mohammad A Zafar, Bulat A Ziganshin, John A Elefteriades
Thoracic aortic aneurysm (TAA) is an increasingly recognized condition that is often diagnosed incidentally. This review discusses ten of the most relevant epidemiological and clinical secrets of this disease; (1) the difference in pathogenesis between ascending and descending TAAs. TAAs at these two sites act as different diseases, which is related to the different embryologic origins of the ascending and descending aorta. (2) The familial pattern and genetics of thoracic aneurysms. Syndromic TAAs only explain 5% of the pattern of inheritance...
December 4, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29204682/pharmacist-led-intervention-in-the-multidisciplinary-team-approach-optimizes-heart-failure-medication
#15
Masanori Suzuki, Yuya Matsue, Sayaka Izumi, Ayako Kimura, Tomoaki Hashimoto, Kentaro Otomo, Hiroshi Saito, Makoto Suzuki, Yasuhisa Kato, Ryohkan Funakoshi
We evaluated the impact of pharmacist-led heart failure (HF) drug recommendations during hospitalization for hospitalized patients with HF. Hospitalized patients with HF were retrospectively reviewed. Patients were hospitalized before (n = 208, non-intervention group) or after (n = 170, intervention group) the launch of the HF multidisciplinary team (HFMDT) approach with pharmacist-led HF medication optimization. There were no significant group differences in patient background characteristics at admission...
December 4, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29204187/use-of-beta-blockers-and-risk-of-serious-upper-gastrointestinal-bleeding-a-population-based-case-control-study
#16
Mette Reilev, Per Damkier, Lotte Rasmussen, Morten Olesen, Martin Thomsen Ernst, Rikke Mie Rishøj, Morten Rix Hansen, Anne Broe, Alexander Steenberg Dastrup, Maja Hellfritzsch, Sidsel Arnspang, Anton Pottegård, Jesper Hallas
Background: Some studies indicate a reduced risk of serious upper gastrointestinal bleeding (UGIB) for users of beta-blockers, but the association remains to be confirmed in larger studies and characterized with respect to differences among beta-blockers. We aimed to assess whether beta-blocker use decreases the risk of UGIB. Methods: We conducted a register-based, population-based case-control study in Denmark. We identified cases with a first validated discharge diagnosis of UGIB during the period 1995-2006...
December 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29198406/comparison-of-the-effect-of-aliskiren-versus-negative-controls-on-aortic-stiffness-in-patients-with-marfan-syndrome-under-treatment-with-atenolol
#17
Ji-Won Hwang, Eun Kyoung Kim, Shin Yi Jang, Tae-Young Chung, Chang-Seok Ki, Kiick Sung, Sung Mok Kim, Joonghyun Ahn, Keumhee Carriere, Yeon Hyeon Choe, Sung-A Chang, Duk-Kyung Kim
INTRODUCTION AND OBJECTIVES: The aim of this study was to evaluate the effect of aliskiren on aortic stiffness in patients with Marfan syndrome (MS). METHODS: Twenty-eight MS patients (mean age ± standard deviation: 32.6 ± 10.6 years) were recruited from November 2009 to October 2014. All patients were receiving atenolol as standard beta-blocker therapy. A prospective randomization process was performed to assign participants to either aliskiren treatment (150-300mg orally per day) or no aliskiren treatment (negative control) in an open-label design...
November 29, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29197871/carvedilol-and-cardiac-biomarkers-in-dialysis-patients-secondary-analysis-of-a-randomized-controlled-trial
#18
Matthew A Roberts, Darsy Darssan, Sunil V Badve, Robert P Carroll, Magid A Fahim, Brian A Haluska, Carmel M Hawley, Nicole M Isbel, Mark R Marshall, Elaine M Pascoe, Eugenie Pedagogos, Helen L Pilmore, Paul Snelling, Tony Stanton, Ken-Soon Tan, Andrew M Tonkin, Liza A Vergara, Francesco L Ierino
BACKGROUND/AIMS: Cardiac biomarkers are associated with cardiac abnormalities and adverse outcomes in dialysis patients. Our aim was to report the effect of the beta-blocker carvedilol on cardiac biomarkers in adult dialysis patients. METHODS: The Beta-Blocker to Lower Cardiovascular Dialysis Events Feasibility Study was a randomized controlled trial comparing carvedilol to placebo. Serum and plasma were collected before the run-in, then 6 and 12 months post-randomization to measure B-type Natriuretic Peptide (BNP), N-terminal BNP (NT-ProBNP), high-sensitivity cardiac troponins I (hs-TnI) and T (hs-TnT), and galectin-3...
December 4, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29194862/a-case-report-is-mexiletine-usage-effective-in-the-shortening-of-qtc-interval-and-improving-the-t-wave-alternans-in-timothy-syndrome
#19
Gulhan Tunca Sahin, Yakup Ergul
Timothy syndrome (TS) is a multisystemic disease that occurs because of a mutation in CACN1C gene and is characterized by prolonged QT interval. Mexiletine is a Class 1B antiarrhythmic drug that causes the disappearance of T-wave alternans by shortening QTc and peak-to-end of the T wave. It may block the development of torsades de pointes in a prolonged QT. This study presented the case of a patient diagnosed with TS and had a cardiac arrest history, prolonged QT, and T-wave alternans. After mexiletine treatment, the QTc interval shortened and T-wave alternans disappeared...
November 30, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29193283/diastolic-dysfunction-in-pulmonary-artery-hypertension-creatine-kinase-and-the-potential-therapeutic-benefit-of-beta-blockers
#20
Ewan D Fowler, Mark J Drinkhill, Rachel Stones, Ed White
Passive properties of the myocardium influence diastolic filling and cardiac output. In heart failure, changes in contributors to the passive properties of the ventricle, such as titin and collagen, and loss of the metabolic enzyme creatine kinase, increase resistance to filling resulting in diastolic dysfunction. Pulmonary artery hypertension (PAH) arises from interactions between the pulmonary vasculature and the right ventricle (RV) which ultimately leads to RV failure. Beta1-adrenergic receptor blockers (BB) act on the myocardium and are beneficial in left heart failure but are not used in PAH...
November 28, 2017: Clinical and Experimental Pharmacology & Physiology
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