Nathan Schmidt, Kristin Van Den Ham, Layne Bower, Shanping Li, Hernan Lorenzi, Safiatou Doumbo, Didier Doumtabe, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Peter Crompton
Malaria is a major public health problem, but many of the factors underlying the pathogenesis of this disease are not well understood. Here, we demonstrate in Malian children that susceptibility to febrile malaria following infection with Plasmodium falciparum is associated with the composition of the gut microbiome prior to the malaria season. Gnotobiotic mice colonized with the fecal samples of malaria-susceptible children had a significantly higher parasite burden following Plasmodium infection compared to gnotobiotic mice colonized with the fecal samples of malaria-resistant children...
April 4, 2024: Research Square