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https://www.readbyqxmd.com/read/28087402/accuracy-is-in-the-eyes-of-the-pathologist-the-visual-interpretive-process-and-diagnostic-accuracy-with-digital-whole-slide-images
#1
Tad T Brunyé, Ezgi Mercan, Donald L Weaver, Joann G Elmore
Digital whole slide imaging is an increasingly common medium in pathology, with application to education, telemedicine, and rendering second opinions. It has also made it possible to use eye tracking devices to explore the dynamic visual inspection and interpretation of histopathological features of tissue while pathologists review cases. Using whole slide images, the present study examined how a pathologist's diagnosis is influenced by fixed case-level factors, their prior clinical experience, and their patterns of visual inspection...
January 10, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28079297/the-effectiveness-of-diclofenac-sodium-in-the-treatment-of-mondor-s-disease-of-the-breast-the-topical-patch-compared-to-the-oral-capsules
#2
Bader Hamza Shirah, Hamza Assad Shirah, Wedad Salem Alonazie
Mondor's disease of the breast is a rare, benign sclerosing superficial thrombophlebitis of the subcutaneous veins of the anterior or lateral chest wall, which is treated conservatively. We aim in this study to evaluate the outcome and effectiveness of our treatment protocol using oral diclofenac sodium and topical diclofenac sodium patch in 172 patients. A retrospective database analysis of 172 female patients between January 2001 and December 2010 was done. The treatment protocol consisted of group 1: treatment by oral diclofenac sodium 100 mg once daily for 3 weeks...
January 12, 2017: Breast Journal
https://www.readbyqxmd.com/read/28079289/apocrine-metaplasia-found-at-mr-biopsy-is-there-something-to-be-learned
#3
Yiming Gao, Vandana Dialani, Carolynn DeBenedectis, Nicole Johnson, Elena Brachtel, Priscilla Slanetz
The purpose of this study was to determine (a) the frequency of apocrine metaplasia (ApoM) found on MR core biopsy of suspicious findings, and (b) to determine if there are specific MR imaging features that might obviate the need for biopsy. This HIPAA-compliant retrospective study was performed under IRB exemption for quality assurance studies. Patient demographics, MR imaging features, and pathology were reviewed. Breast lesions which underwent MR-guided biopsy, yielding ApoM on pathology analysis were included...
January 12, 2017: Breast Journal
https://www.readbyqxmd.com/read/28079249/fractal-analysis-of-visual-search-activity-for-mass-detection-during-mammographic-screening
#4
Folami Alamudun, Hong-Jun Yoon, Kathleen B Hudson, Garnetta Morin-Ducote, Tracy Hammond, Georgia D Tourassi
PURPOSE: The objective of this study is to assess the complexity of human visual search activity during mammographic screening using fractal analysis and to investigate its relationship with case and reader characteristics. METHODS: The study was performed for the task of mammographic screening with simultaneous viewing of four coordinated breast views as typically done in clinical practice. Eye-tracking data and diagnostic decisions collected for 100 mammographic cases (25 normal, 25 benign, 50 malignant) and 10 readers (three board certified radiologists and seven radiology residents), formed the corpus data for this study...
January 12, 2017: Medical Physics
https://www.readbyqxmd.com/read/28077134/endoscopy-assisted-surgery-for-the-management-of-benign-breast-tumors-technique-learning-curve-and-patient-reported-outcome-from-preliminary-323-procedures
#5
Hung-Wen Lai, Hui-Yu Lin, Shu-Ling Chen, Shou-Tung Chen, Dar-Ren Chen, Shou-Jen Kuo
BACKGROUND: Endoscopy-assisted breast surgery (EABS), a technique that optimizes cosmetic outcome because it is performed through small wounds hidden in inconspicuous areas, could be an alternative surgical technique for benign breast tumors. In this study, we report the preliminary results of 323 EABS procedures performed at our institution for the management of benign breast tumors. METHODS: The medical records of patients who underwent EABS for benign breast lesions during the periods August 2010 to December 2015 were collected from the Changhua Christian Hospital EABS database...
January 11, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28076009/delineating-extramammary-findings-at-breast-mr-imaging
#6
Yiming Gao, Opeyemi Ibidapo, Hildegard K Toth, Linda Moy
Breast magnetic resonance (MR) imaging is the only breast imaging modality that consistently encompasses extramammary structures in the thorax and upper abdomen. Incidental extramammary findings on breast MR images of patients with a history of breast cancer or other malignancies are significantly more likely to be malignant and may affect staging and treatment. An understanding of the frequency, distribution, and context of extramammary findings on breast MR images and a familiarity with common and uncommon sites of breast cancer metastasis inform the differential diagnosis and prompt the appropriate diagnostic next step, to differentiate benign from malignant findings...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28073996/estimate-of-false-positive-breast-cancer-diagnoses-from-accuracy-studies-a-systematic-review
#7
REVIEW
Nereo Segnan, Silvia Minozzi, Antonio Ponti, Cristina Bellisario, Sara Balduzzi, Marien González-Lorenzo, Silvia Gianola, Paola Armaroli
BACKGROUND: False-positive histological diagnoses have the same consequences of overdiagnosis in terms of unnecessary treatment. The aim of this systematic review is to assess their frequency at needle core biopsy (CB) and/or surgical excision of the breast. METHODS: PubMed, Embase, Cochrane Library were systematically searched up to 30 October 2015. Eligibility criteria: cross-sectional studies assessing diagnostic accuracy of CB compared with surgical excision; studies assessing reproducibility of pathologists reading the same slides...
January 10, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28072970/-histologic-classification-and-prognosis-factors-in-phyllodes-tumors-of-breast
#8
C Jia, F Mei, J Y Liu, H M Zhao, Y T Lei, J Su, S S Huang, J Zheng, J F You
Objective: To study the relationship between morphological characteristics, grading, diagnosis and prognosis in phyllodes tumors (PT) of the breast. Methods: A retrospective study was carried out on 83 PTs diagnosed between 1999 and 2003 that were classified semi-quantitatively according to the WHO recommendation. Follow-up data was available for some cases, and Cox regression analysis was used to evaluate factors affecting metastasis and recurrence. Results: All cases were classified into the benign (57.8%), borderline (28...
January 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28072477/recurrent-nab2-stat6-gene-fusions-and-estrogen-receptor-alpha-expression-in-pulmonary-adenofibromas
#9
Nicola Fusco, Elena Guerini-Rocco, Claudia Augello, Andrea Terrasi, Giulia Ercoli, Caterina Fumagalli, Davide Vacirca, Paola Braidotti, Antonina Parafioriti, Marta Jaconi, Letterio Runza, Vijayalakshmi Ananthanarayanan, Fabio Pagni, Silvano Bosari, Massimo Barberis, Stefano Ferrero
AIMS: Pulmonary adenofibromas are rare benign fibroepithelial tumours of the lung with unknown histogenesis and an indolent clinical behaviour. Their stroma resembles that of solitary fibrous tumours, while the glands are composed of respiratory epithelium organized in a phyllodes-like architecture. Differentiation of pulmonary adenofibromas from other more aggressive intrathoracic tumours is clinically relevant. However, their biology is unknown. Here, we sought to characterize pulmonary adenofibromas at a clinicopathologic level and to define whether they could be underpinned by a highly recurrent somatic genetic alteration akin to tumours with similar morphology...
January 10, 2017: Histopathology
https://www.readbyqxmd.com/read/28069257/benign-breast-lesions-that-mimic-malignancy
#10
Vanda F Torous, Stuart J Schnitt, Laura C Collins
Many benign and reactive lesions of the breast show morphological overlap with malignant lesions. These benign mimics of malignancy often present diagnostic challenges to even the most experienced pathologists. This review focuses on several benign lesions of the breast that mimic malignant entities. For each of these lesions, we describe the key morphological and immunohistochemical features, potential diagnostic pitfalls, and our approach to arriving at the correct diagnosis.
January 6, 2017: Pathology
https://www.readbyqxmd.com/read/28069161/the-value-of-routine-screening-mammography-in-women-aged-35-39-years-in-a-symptomatic-breast-unit
#11
A Buckley, N Healy, A Quinn, S A O'Keeffe
AIM: To determine the breast cancer detection rate at routine bilateral screening mammography in women aged 35-39 years attending a symptomatic breast clinic, in women of population-risk profile with a normal clinical examination. METHODS AND MATERIALS: A retrospective analysis of all mammograms performed on patients aged 35-39 years at St James's Hospital from 2011-2015 was carried out. Patients with moderate or high familial risk of breast cancer, personal breast cancer history or chest radiation, males, general practitioner (GP) and internal hospital referrals, and those with abnormal clinical examinations were excluded...
January 6, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28067522/development-of-a-postcolumn-infused-internal-standard-liquid-chromatography-mass-spectrometry-method-for-quantitative-metabolomics-studies
#12
Hsiao-Wei Liao, Ching-Hua Kuo, Guan-Yuan Chen, Ming-Shiang Wu, Wei-Chih Liao, Ching-Hung Lin
Quantitative metabolomics has become much more important in clinical research in recent years. Individual differences in matrix effects (MEs) and the injection order effect are two major factors that reduce the quantification accuracy in liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) based metabolomics studies. This study proposed a postcolumn infused-internal standard (PCI-IS) combined with a matrix normalization factor (MNFs) strategy to improve the analytical accuracy of quantitative metabolomics...
January 9, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28066593/diagnostic-performance-of-core-needle-biopsy-in-identifying-breast-phyllodes-tumors
#13
Zhi-Rui Zhou, Chen-Chen Wang, Xiang-Jie Sun, Zhao-Zhi Yang, Xiao-Li Yu, Xiao-Mao Guo
BACKGROUND: A retrospective analysis of diagnoses was performed in patients with phyllodes tumors of the breast (PTB) who received preoperative core needle biopsy (CNB) and had breast surgery at Fudan University Shanghai Cancer Center from January 1, 2002 to April 1, 2013. The resulting data allowed us to compare the accordance between CNB and excision diagnoses of PTB patients and evaluate the accuracy of CNB in preoperative diagnosis. METHODS: Data from 128 patients with PTB who had undergone preoperative CNB and breast surgery were retrospectively analyzed...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28065370/a-new-qualitative-pattern-classification-of-shear-wave-elastograghy-for-solid-breast-mass-evaluation
#14
Rui Cong, Jing Li, Song Guo
OBJECTIVES: To examine the efficacy of qualitative shear wave elastography (SWE) in the classification and evaluation of solid breast masses, and to compare this method with conventional ultrasonograghy (US), quantitative SWE parameters and qualitative SWE classification proposed before. METHODS: From April 2015 to March 2016, 314 consecutive females with 325 breast masses who decided to undergo core needle biopsy and/or surgical biopsy were enrolled. Conventional US and SWE were previously performed in all enrolled subjects...
February 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28064296/the-follow-up-of-post-mastectomy-patients-should-the-ipsilateral-side-be-assessed-with-both-mammogram-and-ultrasound
#15
S Radhika, B Hartini, A Norlia, M P Suria-Hayati, M A Zulfiqar
AIM: This study aimed to determine findings of axillary view mammogram (MMG) and ultrasound (USG) of the ipsilateral side in post-mastectomy patients and to document difficulty level in performing the axillary view and patients' pain level during the procedure. METHODS: Post-mastectomy patients who had MMG and USG on follow-up during an 18-months period were included. The MMG and USG findings of 183 patients were reviewed and histology results were recorded when available...
October 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28062981/body-size-from-birth-through-adolescence-in-relation-to-risk-of-benign-breast-disease-in-young-women
#16
Catherine S Berkey, Bernard Rosner, Rulla M Tamimi, Walter C Willett, Martha Hickey, Adetunji Toriola, A Lindsay Frazier, Graham A Colditz
PURPOSE: Body size, from birth throughout adulthood, is associated with breast cancer risk, but few studies have investigated early-life body size and benign breast disease (BBD), a well-established breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18 year, and intervening growth, are related to BBD risk. METHODS: The Growing Up Today Study includes 9032 females who completed questionnaires annually from 1996 to 2001, then 2003, 2005, 2007, 2010, and 2013...
January 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28062979/contemporary-indications-for-diagnostic-open-biopsy-in-women-assessed-for-screen-detected-breast-lesions-a-ten-year-single-institution-series-of-814-consecutive-cases
#17
Gelareh Farshid, P Grantley Gill
PURPOSE: In contemporary practice, 5% of women with non-malignant needle biopsies of screen-detected lesions still require diagnostic open biopsy (OBx). Our aims are to (i) capture a snapshot of the contemporary indications for OBx in screen-detected lesions; (ii) determine upgrade rates to malignancy (DCIS or invasive cancer); (iii) identify indications with sufficiently low upgrades to justify avoidance of OBx and (iv) propose plausible non-surgical alternatives. METHODS: Between Jan 2005 and Dec 2014, women assessed for a screen-detected lesion and recommended for OBx are included...
January 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28062964/mammotome-assisted-liposuction-a-novel-technique-for-accessory-breasts
#18
Xin Tang
INTRODUCTION: Due to its minimally invasive and highly precise nature, the mammotome, a vacuum-assisted breast biopsy device, has proven effective for the treatment of benign breast lesions. Taking advantage of both liposuction and the mammotome, we utilized the mammotome device for the excision of accessory breasts. METHODS: Between July 2010 and June 2014, 16 patients with accessory breasts received mammotome-assisted liposuction. After adipose was removed using this procedure, the mammotome system was used to excise the fibro-glandular tissue in accessory breasts under ultrasound monitoring...
January 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28058811/proteomic-characterization-of-microdissected-breast-tissue-environment-provides-a-protein-level-overview-of-malignant-transformation
#19
René B H Braakman, Christoph Stingl, Madeleine M A Tilanus-Linthorst, Carolien H M Deurzen, Mieke A M Timmermans, Marcel Smid, John A Foekens, Theo M Luider, John W M Martens, Arzu Umar
Both healthy and cancerous breast tissue is heterogeneous, which is a bottle-neck for proteomics-based biomarker analysis, as it obscures the cellular origin of a measured protein. We therefore aimed at obtaining a protein-level interpretation of malignant transformation through global proteome analysis of a variety of laser capture microdissected cells originating from benign and malignant breast tissues. We compared proteomic differences between these tissues, both from cells of epithelial origin and the stromal environment, and performed string analysis...
January 5, 2017: Proteomics
https://www.readbyqxmd.com/read/28058550/do-calcifications-seen-on-mammography-after-neoadjuvant-chemotherapy-for-breast-cancer-always-need-to-be-excised
#20
Yara Feliciano, Anita Mamtani, Monica Morrow, Michelle M Stempel, Sujata Patil, Maxine S Jochelson
BACKGROUND: This study aimed to determine the relationship between mammographic calcifications and magnetic resonance imaging (MRI) tumoral enhancement before and after neoadjuvant chemotherapy (NAC) and to assess the impact of these findings on surgical management. METHODS: This Institutional Review Board-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant retrospective study involved breast cancer patients who underwent NAC between 2009 and 2015...
January 5, 2017: Annals of Surgical Oncology
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