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https://www.readbyqxmd.com/read/28726720/tgf-%C3%AE-dependent-growth-arrest-and-cell-migration-in-benign-and-malignant-breast-epithelial-cells-are-antagonistically-controlled-by-rac1-and-rac1b
#1
Catharina Melzer, Juliane von der Ohe, Ralf Hass, Hendrik Ungefroren
Despite improvements in diagnosis and treatment, breast cancer is still the most common cancer type among non-smoking females. TGF-β can inhibit breast cancer development by inducing cell cycle arrest in both, cancer cells and, as part of a senescence program in normal human mammary epithelial cells (HMEC). Moreover, TGF-β also drives cell migration and invasion, in part through the small GTPases Rac1 and Rac1b. Depletion of Rac1b or Rac1 and Rac1b in MDA-MB-231 or MDA-MB-435s breast cancer cells by RNA interference enhanced or suppressed, respectively, TGF-β1-induced migration/invasion...
July 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28724885/invasive-ductal-carcinoma-within-a-benign-phyllodes-tumor
#2
Nancy Panko, Anwar A Jebran, Ameer Gomberawalla, Mark Connolly
BACKGROUND Phyllodes tumor (PT) is a rare neoplasm of the breast. Concomitant PT with invasive ductal carcinoma (IDC) is an even rarer occurrence. When ductal carcinoma in situ (DCIS) or IDC are detected within the specimen, the management changes from wide local excision to further staging work-up, including sentinel node biopsy and radiation. CASE REPORT We report the case of a 70-year-old presented with right breast mass whose pathology showed benign PT with concomitant IDC and DCIS. The patient elected for a wide excision of the mass with sentinel lymph node biopsy, which did not show any involvement...
July 20, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28715278/bi-rads-category-3-comparison-probably-benign-category-after-recall-from-screening-before-and-after-implementation-of-digital-breast-tomosynthesis
#3
Elizabeth S McDonald, Anne Marie McCarthy, Susan P Weinstein, Mitchell D Schnall, Emily F Conant
Purpose To evaluate Breast Imaging Reporting and Data System (BI-RADS) category 3 assessment at diagnostic examination after recall from screening in a large urban population after implementation of digital breast tomosynthesis (DBT) by focusing both on overall use and use stratified by recalled finding type and outcome at 2 years. Materials and Methods This was an intuitional review board-approved and HIPAA-compliant retrospective review of 10 728 digital mammography (DM) examinations from September 1, 2010, to August 30, 2011, and 15 571 screening DBT examinations from October 1, 2011, to February 28, 2013...
July 17, 2017: Radiology
https://www.readbyqxmd.com/read/28713696/bilateral-axillo-breast-approach-robotic-thyroidectomy-review-of-evidences
#4
REVIEW
Shirley Yuk-Wah Liu, Jee Soo Kim
The bilateral axillo-breast approach (BABA) is one of the most popular contemporary remote-access thyroidectomy techniques. While the initial experiences with BABA endoscopic thyroidectomy (ET) were associated with some technical challenges and safety concerns, many limitations of the technique could now be substantially overcome by BABA robotic thyroidectomy (RT). In this review, the current literature evidences of BABA RT were analyzed. Data regarding the patient selection, the learning curve, and the comparison with open thyroidectomy (OT) and BABA ET were examined...
June 2017: Gland Surgery
https://www.readbyqxmd.com/read/28708818/regional-contrast-enhanced-ultrasonography-ceus-characteristics-of-breast-cancer-and-correlation-with-microvessel-density-mvd
#5
Xiaoling Leng, Guofu Huang, Fucheng Ma, Lanhui Yao
BACKGROUND The aim of this study was to investigate the perfusion characteristics of different breast lesion regions in contrast-enhanced ultrasonography (CEUS). MATERIAL AND METHODS A total of 161 malignant and benign breast lesion cases were subjected to CEUS. Perfusion parameters were analyzed and compared between the central and peripheral lesion regions, and surrounding tissue. Mass section was marked with methylene blue. Samples were subjected to immunohistochemistry, and microvessel density (MVD) was calculated...
July 14, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28708299/shear-wave-elastography-for-surgically-verified-breast-papillary-lesions-is-it-effective-for-differentiation-between-benign-and-malignant-lesions
#6
Hye Jeong Choi, Kyung Hee Ko, Hae Kyoung Jung
OBJECTIVES: To evaluate the effectiveness of shear wave elastography (SWE) for differentiating benign from malignant breast papillary lesions METHODS: B-mode ultrasound (US) and SWE were available in 56 surgically confirmed papillary lesions (48 [85.7%] benign and 8 [14.3%] malignant). The diagnostic performances of US, SWE parameters, and combined US with SWE parameters were calculated by receiver operating characteristic curve analysis and compared. RESULTS: The highest area under the receiver operating characteristic curve (Az ) value for US was 0...
July 14, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28708250/cutaneous-syncytial-myoepithelioma-a-recently-described-neoplasm-which-may-mimic-nevoid-melanoma-and-epithelioid-sarcoma
#7
Ahmed K Alomari, Noah Brown, Aleodor Andea, Bryan L Betz, Rajiv M Patel
Myoepithelial cells possess dual immunohistochemical and ultrastructural features of smooth muscle cells and epithelial cells and are capable of divergent differentiation (1). As such, benign and malignant tumors of myoepithelial cells show a spectrum of morphologies and have been reported in a variety of anatomic locations, including but not limited to, the breast, larynx, soft tissues, salivary glands and more recently the skin (2-6).
July 14, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28699175/long-term-health-outcomes-of-adults-with-mccune-albright-syndrome
#8
S C Wong, M Zacharin
CONTEXT: McCune Albright Syndrome (MAS) is associated with numerous health problems. Comprehensive long term health problems of adults with MAS are less well defined in the literature. OBJECTIVE: Our objective is to report comprehensive health outcomes of adults with MAS (> 18 years). DESIGN: Retrospective case note review of 16 adults with MAS managed by one clinician. Results expressed as median (range) RESULTS: The study included 16 adults (7 males) with MAS...
July 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28698632/quality-measurement-of-two-dimensional-shear-wave-speed-imaging-for-breast-lesions-the-associated-factors-and-the-impact-to-diagnostic-performance
#9
Dan-Dan Li, Hui-Xiong Xu, Bo-Ji Liu, Xiao-Wan Bo, Xiao-Long Li, Rong Wu
This study aimed to identify the associated factors for quality measurement (QM) of shear wave speed (SWS) imaging and to validate the additional value of QM in the diagnosis of breast lesions. From September 2014 to February 2015, conventional ultrasound and SWS imaging were performed in 338 women with 361 breast lesions. Binary logistic regression was used to identify associated factors for QM. Sensitivity, specificity and the area under receiver operating characteristic (ROC) curve (AUC) among maximum SWS (SWS max ), QM and SWS max plus QM (SWS max +QM) were compared to validate additional value of QM...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693214/clustering-of-patients-with-intrahepatic-cholangiocarcinoma-based-on-serum-periostin-may-be-predictive-of-prognosis
#10
Chanitra Thuwajit, Peti Thuwajit, Pranisa Jamjantra, Chawalit Pairojkul, Sopit Wongkham, Vajarabhongsa Bhudhisawasdi, Junya Ono, Shoichiro Ohta, Kiminori Fujimoto, Kenji Izuhara
An effective serum biomarker may improve cholangiocarcinoma (CCA) management. Periostin (PN) has been demonstrated to be associated with aggressive CCA. The current study evaluated PN in blood serum for its diagnostic and prognostic potential in patients with CCA. Sera of 68 patients with CCA were collected prior to treatment, and PN levels were measured using an ELISA. Sera from 50 normal controls, 6 patients with benign liver diseases, 2 with hepatocellular carcinoma and 21 with breast cancer were analyzed...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28690935/acoustic-radiation-force-impulse-imaging-in-benign-and-malignant-breast-lesions
#11
Jayapriya Jayaraman, Venkatraman Indiran, Kanakaraj Kannan, Prabakaran Maduraimuthu
BACKGROUND: Elastography is a promising way to assess tissue differences regarding stiffness or elasticity, which has been historically assessed manually by palpation. Combined with conventional imaging modalities, shear wave elastography can potentially evaluate the stiffness of a breast lesion and consequently help detect malignant breast tumor from benign ones. The aim of this study was to evaluate the diagnostic role of shear wave elastography in breast lesions in the Indian population...
June 1, 2017: Curēus
https://www.readbyqxmd.com/read/28689011/coexistence-of-ductal-carcinoma-within-mammary-phyllodes-tumor-a-review-of-557-cases-from-a-20-year-region-wide-database-in-hong-kong-and-southern-china
#12
Michael Co, Gary M Tse, Clement Chen, Jiannan Wei, Ava Kwong
INTRODUCTION: Phyllodes tumor (PT) is an uncommon fibroepithelial tumor of the breast showing predominately proliferation of the stromal component. The presence of ductal carcinoma in situ (DCIS) or invasive ductal carcinoma is rare, with only a few cases reported in the literature. METHODS: A retrospective review of a prospectively maintained database was performed. Patients who were treated for PT in 5 hospitals in Hong Kong and Shenzhen, China over a period of 20 years (1997-2016) were evaluated...
June 17, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28688536/fibroepithelial-lesions-the-who-spectrum
#13
REVIEW
Gregor Krings, Gregory R Bean, Yunn-Yi Chen
Fibroepithelial lesions of the breast comprise a morphologically and biologically heterogeneous group of biphasic tumors with epithelial and stromal components that demonstrate widely variable clinical behavior. Fibroadenomas are common benign tumors with a number of histologic variants, most of which pose no diagnostic challenge. Cellular and juvenile fibroadenomas can have overlapping features with phyllodes tumors and should be recognized. Phyllodes tumors constitute a spectrum of lesions with varying clinical behavior and are graded as benign, borderline or malignant based on a set of histologic features according to recommendations by the World Health Organization (WHO)...
May 28, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28688490/a-fourth-order-pde-based-fuzzy-c-means-approach-for-segmentation-of-microscopic-biopsy-images-in-presence-of-poisson-noise-for-cancer-detection
#14
Rajesh Kumar, Subodh Srivastava, Rajeev Srivastava
BACKGROUND AND OBJECTIVE: For cancer detection from microscopic biopsy images, image segmentation step used for segmentation of cells and nuclei play an important role. Accuracy of segmentation approach dominate the final results. Also the microscopic biopsy images have intrinsic Poisson noise and if it is present in the image the segmentation results may not be accurate. The objective is to propose an efficient fuzzy c-means based segmentation approach which can also handle the noise present in the image during the segmentation process itself i...
July 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28688156/comparison-and-combination-of-strain-and-shear-wave-elastography-of-breast-masses-for-differentiation-of-benign-and-malignant-lesions-by-quantitative-assessment-preliminary-study
#15
Mirinae Seo, Hye Shin Ahn, Sung Hee Park, Jong Beum Lee, Byung Ihn Choi, Yu-Mee Sohn, So Youn Shin
OBJECTIVES: To compare the diagnostic performance of strain and shear wave elastography of breast masses for quantitative assessment in differentiating benign and malignant lesions and to evaluate the diagnostic accuracy of combined strain and shear wave elastography. METHODS: Between January and February 2016, 37 women with 45 breast masses underwent both strain and shear wave ultrasound (US) elastographic examinations. The American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) final assessment on B-mode US imaging was assessed...
July 8, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28687909/post-clip-placement-mri-following-second-look-us-guided-core-biopsy-for-suspicious-lesions-identified-on-breast-mri
#16
Sung Eun Song, Nariya Cho, Wonshik Han
OBJECTIVES: To evaluate whether the post-clip placement MRI following second-look ultrasound (US)-guided core biopsy is useful to confirm the adequate sampling of suspicious lesions identified on breast MRI. METHODS: Between 2014 and 2016, 31 consecutive women with 34 suspicious lesions that had not been identified on previous mammography or US were detected using MRI. Among them, 26 women with 29 lesions (mean size 1.5 cm, range 0.5-5.8 cm) found by second-look US underwent US-guided biopsy, subsequent clip insertion and post-clip placement MRI...
July 7, 2017: European Radiology
https://www.readbyqxmd.com/read/28686500/guidelines-for-pathologic-diagnosis-of-malignant-mesothelioma-2017-update-of-the-consensus-statement-from-the-international-mesothelioma-interest-group
#17
Aliya Noor Husain, Thomas V Colby, Nelson G Ordóñez, Timothy Craig Allen, Richard Luther Attanoos, Mary Beth Beasley, Kelly Jo Butnor, Lucian R Chirieac, Andrew M Churg, Sanja Dacic, Françoise Galateau-Sallé, Allen Gibbs, Allen M Gown, Thomas Krausz, Leslie Anne Litzky, Alberto Marchevsky, Andrew G Nicholson, Victor Louis Roggli, Anupama K Sharma, William D Travis, Ann E Walts, Mark R Wick
CONTEXT: - Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. OBJECTIVE: - To provide updated, practical guidelines for the pathologic diagnosis of MM. DATA SOURCES: - Pathologists involved in the International Mesothelioma Interest Group and others with an interest and expertise in the field contributed to this update. Reference material included up-to-date, peer-reviewed publications and textbooks. CONCLUSIONS: - There was discussion and consensus opinion regarding guidelines for (1) distinguishing benign from malignant mesothelial proliferations (both epithelioid and spindle cell lesions), (2) cytologic diagnosis of MM, (3) recognition of the key histologic features of pleural and peritoneal MM, (4) use of histochemical and immunohistochemical stains in the diagnosis and differential diagnosis of MM, (5) differentiating epithelioid MM from various carcinomas (lung, breast, ovarian, and colonic adenocarcinomas, and squamous cell and renal cell carcinomas), (6) diagnosis of sarcomatoid MM, (7) use of molecular markers in the diagnosis of MM, (8) electron microscopy in the diagnosis of MM, and (9) some caveats and pitfalls in the diagnosis of MM...
July 7, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28683503/focal-breast-lesions-in-clinical-ct-examinations-of-the-chest-a-retrospective-analysis
#18
Kathrin Barbara Krug, Christian Houbois, Olga Grinstein, Jan Borggrefe, Michael Puesken, Bettina Hanstein, Wolfram Malter, David Maintz, Martin Hellmich
Purpose Based on radiological reports, the percentage of breast cancers visualized as incidental findings in routine CT examinations is estimated at ≤ 2 %. In view of the rising number of CT examinations and the high prevalence of breast cancer, it was the goal of the present study to verify the frequency and image morphology of false-negative senological CT findings. Materials and Methods All first contrast-enhanced CT examinations of the chest in adult female patients carried out in 2012 were retrospectively included...
July 6, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28681104/benign-breast-disease-and-risk-of-thyroid-cancer
#19
Juhua Luo, Michael Hendryx, Rami Nassir, Ting-Yuan David Cheng, Dorothy Lane, Karen L Margolis
BACKGROUND: It has been suggested that breast and thyroid diseases may be linked. The aim of this study was to investigate the association between benign breast disease and subsequent risk of thyroid cancer. METHODS: Postmenopausal women (n = 133,875) aged 50-79 years were followed up for a mean of 14 years. Benign breast disease was defined by history of biopsy. Incident thyroid cancer cases were confirmed by medical record review. Multivariable Cox proportional hazard modeling was used to estimate hazard ratios...
July 6, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28681097/characterizing-diagnostic-search-patterns-in-digital-breast-pathology-scanners-and-drillers
#20
Ezgi Mercan, Linda G Shapiro, Tad T Brunyé, Donald L Weaver, Joann G Elmore
Following a baseline demographic survey, 87 pathologists interpreted 240 digital whole slide images of breast biopsy specimens representing a range of diagnostic categories from benign to atypia, ductal carcinoma in situ, and invasive cancer. A web-based viewer recorded pathologists' behaviors while interpreting a subset of 60 randomly selected and randomly ordered slides. To characterize diagnostic search patterns, we used the viewport location, time stamp, and zoom level data to calculate four variables: average zoom level, maximum zoom level, zoom level variance, and scanning percentage...
July 5, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
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