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benign breast

Irene Fondón, Auxiliadora Sarmiento, Ana Isabel García, María Silvestre, Catarina Eloy, António Polónia, Paulo Aguiar
Breast cancer is the second leading cause of cancer death among women. Its early diagnosis is extremely important to prevent avoidable deaths. However, malignancy assessment of tissue biopsies is complex and dependent on observer subjectivity. Moreover, hematoxylin and eosin (H&E)-stained histological images exhibit a highly variable appearance, even within the same malignancy level. In this paper, we propose a computer-aided diagnosis (CAD) tool for automated malignancy assessment of breast tissue samples based on the processing of histological images...
March 8, 2018: Computers in Biology and Medicine
Juhun Lee, Robert M Nishikawa, Ingrid Reiser, John M Boone
We proposed the neutrosophic approach for segmenting breast lesions in breast computed tomography (bCT) images. The neutrosophic set considers the nature and properties of neutrality (or indeterminacy). We considered the image noise as an indeterminate component while treating the breast lesion and other breast areas as true and false components. We iteratively smoothed and contrast-enhanced the image to reduce the noise level of the true set. We then applied one existing algorithm for bCT images, the RGI segmentation, on the resulting noise-reduced image to segment the breast lesions...
January 2018: Journal of Medical Imaging
Bin Deng, Mats Lundqvist, Qianqian Fang, Stefan A Carp
Near-infrared diffuse optical tomography (NIR-DOT) is an emerging technology that offers hemoglobin based, functional imaging tumor biomarkers for breast cancer management. The most promising clinical translation opportunities are in the differential diagnosis of malignant vs. benign lesions, and in early response assessment and guidance for neoadjuvant chemotherapy. Accurate quantification of the tissue oxy- and deoxy-hemoglobin concentration across the field of view, as well as repeatability during longitudinal imaging in the context of therapy guidance, are essential for the successful translation of NIR-DOT to clinical practice...
March 1, 2018: Biomedical Optics Express
Kamil Pohlodek, Peter Jáni, Iveta Mečiarová
A granular cell tumor (GCT), is a rare soft tissue tumor which may occur throughout the body, usually in the head and neck, skin or subcutaneous tissues of the trunk and upper extremities, and female genital region. A total of 5-8% of all cases of GCTs occur in the breast. GCT of the breast may mimic breast cancer both clinically and radiologically. GCTs are usually benign and solitary; however, approximately 2% occur as malignant tumors. Benign GCTs are treated with wide local excision and are associated with a good prognosis...
April 2018: Molecular and Clinical Oncology
Jingkun Qu, Xixi Zhao, Jizhao Wang, Chao Liu, Yuchen Sun, Hui Cai, Jianlin Liu
Previous studies have indicated that phospholipase A2 (PLA2) may be associated with tumorigenesis in human tissues. The present study aimed to investigate the association between plasma PLA2 activity and the breast cancer (BC) status of patients. Increased plasma PLA2 activity was detected in patients with breast cancer when compared with healthy controls. Plasma samples were obtained from patients with BC (n=169), patients with benign disease (BD; n=80) and healthy controls (n=81). PLA2 activity was assessed using a quantitative fluorescent assay with selective inhibitors...
April 2018: Oncology Letters
Modupeola Omotara Samaila, Halima Oziohu Aliyu, Lazarus Mungu Yusufu, Shehu Abdullahi
Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon benign mesenchymal tumor of the breast. Majority occur as diffuse lesions, and diagnosis is often incidental or in a background of other breast pathologies. Bilaterality with multiple tumoral masses in giant breasts is a rarity. We report a 34-year-old nonlactating female with 2-year history of rapid progressive painless bilateral enlargement of the breasts following surgical excision of ill-defined breast lumps which were not subjected to histopathological evaluation a year earlier...
April 2018: Annals of African Medicine
Olivia Ihedioha, Anne A Blanchard, Jyoti Balhara, Ifeoma Okwor, Ping Jia, Jude Uzonna, Yvonne Myal
The prolactin-inducible protein (PIP) is considered a valuable biomarker that is associated with both benign and malignant pathological conditions of the mammary gland. The function of PIP in breast tumorigenesis remains unknown; however, evidence from our laboratory and others suggest that it regulates host immunity. Studies with PIP-deficient (PIP-/- ) mice demonstrated significantly lower numbers of CD4+ T cells in their secondary lymphoid organs, impaired Th1 response, and impaired nitric oxide (NO) production...
March 13, 2018: Immunologic Research
Daryl Ramai, Jonathan Lai, Kinesh Changela, Sury Anand
Granular cell tumors (GCTs) are rare and benign tumors that can occur at any anatomical site. GCTs are thought to originate from nerve cells, particularly Schwann cells. Their name derives from the fact that an accumulation of cytoplasmic lysosomes imparts the tumor with a granular appearance. They are most commonly observed in the oral cavity, skin and subcutaneous tissue, breast, and respiratory tract. Granular cell tumors rarely affect the gastrointestinal tract. We report a 58-year-old female with a past medical history of hypertension, mitral valve prolapse, and depression who presented for surveillance colonoscopy...
January 2, 2018: Curēus
Qian Li, Min Hu, Zhikui Chen, Changtian Li, Xi Zhang, Yiqing Song, Feixiang Xiang
This meta-analysis aimed to compare the diagnostic performance of contrast-enhanced ultrasound (CEUS), conventional ultrasound (US) combined with CEUS (US + CEUS) and US for distinguishing breast lesions. From thorough literature research, studies that compared the diagnostic performance of CEUS versus US or US + CEUS versus US, using pathology results as the gold standard, were included. A total of 10 studies were included, of which 9 compared the diagnostic performance of CEUS and US, and 5 studies compared US + CEUS and US...
March 9, 2018: Ultrasound in Medicine & Biology
Cedric W Pluguez-Turull, Jennifer E Nanyes, Cristina J Quintero, Hamza Alizai, Daniel D Mais, Kenneth A Kist, Nella C Dornbluth
Idiopathic granulomatous mastitis (IGM) is a rare benign inflammatory breast entity characterized by lobulocentric granulomas. IGM has a persistent or recurrent disease course and affects parous premenopausal women with a history of lactation. It has also been associated with hyperprolactinemia. The most common clinical sign is a palpable tender mass. However, the nonspecific manifestations and varied demographic features of this condition, as well as the other similar-appearing and superimposed breast entities, pose substantial diagnostic challenges...
March 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Hae Kyoung Jung, Ah Young Park, Kyung Hee Ko, Jieun Koh
This study was performed to compare the diagnostic performance of power Doppler ultrasound (US) and a new microvascular Doppler US technique (AngioPLUS; SuperSonic Imagine, Aix-en-Provence, France) for differentiating benign and malignant breast masses. Power Doppler US and AngioPLUS findings were available in 124 breast masses with confirmed pathologic results (benign, 80 [64.5%]; malignant, 44 [35.5%]). The diagnostic performance of each tool was calculated to distinguish benign from malignant masses using a receiver operating characteristic curve analysis and compared...
March 12, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Jun Zhang, Tiemei Zhang, Nan Wu, Xinhua Zhao, Qingsong Wang, Yanyang Jiang, Ming Gao, Lin Gu
BACKGROUND: Intracystic papillary carcinoma (IPC) is a rare breast neoplasm. There are few studies focusing on its clinical features and limited data about its preoperative diagnosis,treatment and outcomes. The purpose of this study is to explore specific characteristics of patients with IPC, investigate its clinicopathological features, prognosis in China and confirm its surgery management. METHODS: We identified 111 patients with IPC from the registry of Tianjin Medical University Cancer Institute and Hospital between 2004 and 2017...
March 8, 2018: Pathology, Research and Practice
Mark D Aupperlee, Anastasia Kariagina, Nicole Zaremba, Marc D Basson, Richard C Schwartz, Sandra Z Haslam
Increased proliferation and breast cancer risk has been observed in postmenopausal women receiving estrogen (E) + progestin hormone replacement therapy (HRT). Progestin action is mediated through two progesterone receptor (PR) isoforms, PRA and PRB, with unique transcriptional activity and function. The current study examines hormonal regulation of PR isoforms in the normal postmenopausal human breast and the mechanism by which progestins increase proliferation and breast cancer risk. Archival benign breast biopsies from postmenopausal and premenopausal women, and luminal breast tumor biopsies from postmenopausal women, were analyzed for regulation of PRA and PRB expression by E and E+medroxyprogesterone acetate (MPA)...
March 7, 2018: Translational Oncology
Yu-Mee Sohn, Mirinae Seo
PURPOSE: To compare breast stiffness based on shear-wave elastography (SWE) quantitative parameters with histopathologic results diagnosed by ultrasound (US)-guided core needle biopsy (CNB) to determine their association with upgrade rates after surgical excision or follow-up US as well as clinico-radiologic differences between upgrade and non-upgrade groups. MATERIALS AND METHODS: This retrospective study enrolled 225 breast lesions from 225 patients, including 159 benign lesions, 38 high risk lesions and 28 ductal carcinoma in situ (DCIS) diagnosed by US-guided CNB...
March 3, 2018: Clinical Imaging
M F Rodrigues, P T Truong, E C McKevitt, L M Weir, M A Knowling, E S Wai
PURPOSE: Phyllodes tumors of the breast are uncommon fibroepithelial lesions for which optimal management remains unclear. This retrospective population-based study reports treatment and outcomes for patients with phyllodes tumors and evaluates characteristics that influence outcome. MATERIALS AND METHODS: Data were analysed on 183 patients with newly diagnosed phyllodes tumors from 1999 to 2014. Five-year Kaplan-Meier local recurrence and survival were compared between cohorts with benign (n=83), borderline (n=50) and malignant phyllodes tumor (n=49) histology...
March 7, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Marta Giussani, Elena Landoni, Giuseppe Merlino, Federica Turdo, Silvia Veneroni, Biagio Paolini, Vera Cappelletti, Rosalba Miceli, Rosaria Orlandi, Tiziana Triulzi, Elda Tagliabue
Changes in amount and composition of extracellular matrix (ECM) are considered a hallmark of tumor development. We tested the hypothesis that abnormal production of ECM components leads to blood-released ECM molecules representing tumor circulating biomarkers. Candidate genes were selected through class comparison in two publicly available datasets and confirmed in paired normal and tumor associated fibroblasts from breast carcinoma (BC) specimens. Production and release of ECM molecules were evaluated in normal human dermal fibroblasts (NHDFs) treated with conditioned media from three BC cell lines...
March 9, 2018: Journal of Cellular Physiology
Neil M Carleton, Guangjing Zhu, Mikhail Gorbounov, M Craig Miller, Kenneth J Pienta, Linda M S Resar, Robert W Veltri
BACKGROUND: There are few tissue-based biomarkers that can accurately predict prostate cancer (PCa) progression and aggressiveness. We sought to evaluate the clinical utility of prostate and breast overexpressed 1 (PBOV1) as a potential PCa biomarker. METHODS: Patient tumor samples were designated by Grade Groups using the 2014 Gleason grading system. Primary radical prostatectomy tumors were obtained from 48 patients and evaluated for PBOV1 levels using Western blot analysis in matched cancer and benign cancer-adjacent regions...
March 9, 2018: Prostate
Marta Román, Martin Caicoya, Josep Espinàs, Maria Sala, Isabel Torá-Rocamora, Maria J Quinta, Mar Vernet, Francina Saladié, Anabel Romero, Mar Sánchez, Marisa Baré, Carmen Vidal, S Servitja, Carmen Natal, Joosep Corominas, Joana Ferrer, Ana Rodríguez-Arana, Xavier Castells
Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69 years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012...
March 8, 2018: Breast Journal
Wenqing Sun, Tzu-Liang Bill Tseng, Wei Qian, Edward C Saltzstein, Bin Zheng, Hui Yu, Shi Zhou
PURPOSE: To help improve efficacy of screening mammography and eventually establish an optimal personalized screening paradigm, this study aimed to develop and test a new near-term breast cancer risk prediction scheme based on the quantitative analysis of ipsilateral view of the negative screening mammograms. METHODS: The dataset includes digital mammograms acquired from 392 women with two sequential full-field digital mammography examinations. All the first ("prior") sets of mammograms were interpreted as negative during the original reading...
March 2018: Computer Methods and Programs in Biomedicine
Jun-Dong Wu, Chao-Qun Hong, Wen-He Huang, Xiao-Long Wei, Fan Zhang, Yi-Xuan Zhuang, Yong-Qu Zhang, Guo-Jun Zhang
INTRODUCTION: The L1 cell adhesion molecule (L1-CAM) and its soluble form sL1 play a prominent role in invasion and metastasis in several cancers. However, its association with breast cancer is still unclear. PATIENTS AND METHODS: We analyzed L1-CAM expression and serum sL1 levels in cancer and para-carcinoma tissues from 162 consecutive patients with primary invasive breast cancer (PBC) using immunohistochemistry and an enzyme-linked immunosorbent assay, respectively...
December 28, 2017: Clinical Breast Cancer
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