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https://www.readbyqxmd.com/read/28436410/a-new-approach-to-develop-computer-aided-diagnosis-scheme-of-breast-mass-classification-using-deep-learning-technology
#1
Yuchen Qiu, Shiju Yan, Rohith Reddy Gundreddy, Yunzhi Wang, Samuel Cheng, Hong Liu, Bin Zheng
PURPOSE: To develop and test a deep learning based computer-aided diagnosis (CAD) scheme of mammograms for classifying between malignant and benign masses. METHODS: An image dataset involving 560 regions of interest (ROIs) extracted from digital mammograms was used. After down-sampling each ROI from 512×512 to 64×64 pixel size, we applied an 8 layer deep learning network that involves 3 pairs of convolution-max-pooling layers for automatic feature extraction and a multiple layer perceptron (MLP) classifier for feature categorization to process ROIs...
April 18, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/28436405/a-comparison-of-methods-for-three-class-mammograms-classification
#2
Marina Milosevic, Zeljko Jovanovic, Dragan Jankovic
BACKGROUND: Mammography is considered the gold standard for early breast cancer detection but it is very difficult to interpret mammograms for many reason. Computer aided diagnosis (CAD) is an important development that may help to improve the performance in breast cancer detection. OBJECTIVE: We present a CAD system based on feature extraction techniques for detecting abnormal patterns in digital mammograms. METHODS: Computed features based on gray-level co-occurrence matrices (GLCM) are used to evaluate the effectiveness of textural information possessed by mass regions...
April 14, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28433983/pulmonary-metastasis-from-renal-epithelioid-angiomyolipoma-in-the-setting-of-breast-cancer
#3
Eoin MacCraith, Aoife McCarthy, Niall Swan, David Quinlan
A 68-year-old woman presented with visible haematuria. Ultrasonography and triphasic CT revealed a 2.6 cm mass in the lower pole of the left kidney. A biopsy suggested low-grade renal cell carcinoma. Radical nephrectomy was performed and revealed an epithelioid angiomyolipoma. At year 3, the patient developed ductal carcinoma of the right breast and underwent a wide local excision and sentinel lymph node biopsy followed by chemotherapy and radiotherapy. 4 months later, she was noted to have a 1.6 cm nodule in the middle lobe of her right lung...
April 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28433440/spatial-compounding-technique-to-obtain-rotation-elastogram-a-feasibility-study
#4
AliArshad Kothawala, Sowmiya Chandramoorthi, N Ravi Kiran Reddy, Arun Kumar Thittai
The perception of stiffness and slipperiness of a breast mass on palpation is used by physicians to assess the level of suspicion of a lesion as being malignant or benign. However, most current ultrasound elastography imaging methods provide only stiffness-related information. There is no existing approach that provides information about the local rigid body rotation undergone by only a loosely bonded, asymmetrically oriented lesion subjected to a small quasi-static compression. The inherent poor lateral resolution in ultrasound imaging poses a limitation in estimating the local rigid body rotation...
April 19, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28430555/beyond-wires-and-seeds-reflector-guided-breast-lesion-localization-and-excision
#5
Victoria L Mango, Ralph T Wynn, Sheldon Feldman, Lauren Friedlander, Elise Desperito, Sejal N Patel, Ameer Gomberawalla, Richard Ha
Purpose To evaluate outcomes of Savi Scout (Cianna Medical, Aliso Viejo, Calif) reflector-guided localization and excision of breast lesions by analyzing reflector placement, localization, and removal, along with target excision and rates of repeat excision (referred to as re-excision). Materials and Methods A single-institution retrospective review of 100 women who underwent breast lesion localization and excision by using the Savi Scout surgical guidance system from June 2015 to May 2016 was performed. By using image guidance 0-8 days before surgery, 123 nonradioactive, infrared-activated, electromagnetic wave reflectors were percutaneously inserted adjacent to or within 111 breast targets...
April 21, 2017: Radiology
https://www.readbyqxmd.com/read/28429195/computer-assisted-diagnosis-system-for-breast-cancer-in-computed-tomography-laser-mammography-ctlm
#6
Afsaneh Jalalian, Syamsiah Mashohor, Rozi Mahmud, Babak Karasfi, M Iqbal Saripan, Abdul Rahman Ramli
Computed tomography laser mammography (Eid et al. Egyp J Radiol Nucl Med, 37(1): p. 633-643, 1) is a non-invasive imaging modality for breast cancer diagnosis, which is time-consuming and challenging for the radiologist to interpret the images. Some issues have increased the missed diagnosis of radiologists in visual manner assessment in CTLM images, such as technical reasons which are related to imaging quality and human error due to the structural complexity in appearance. The purpose of this study is to develop a computer-aided diagnosis framework to enhance the performance of radiologist in the interpretation of CTLM images...
April 20, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28427743/microbubble-detection-and-ultrasound-guided-vacuum-assisted-biopsy-of-axillary-lymph-nodes-in-patients-with-breast-cancer
#7
P Britton, P Willsher, K Taylor, F Kilburn-Toppin, E Provenzano, P Forouhi, J Benson, A Agrawal, J R Forman, M G Wallis
AIMS: To assess the feasibility of undertaking microbubble-guided vacuum-assisted biopsy (VAB) of the sentinel lymph node (SLN) and determine its sensitivity in detecting metastases. Patient experience and the impact of VAB on subsequent axillary surgery were also evaluated. MATERIALS AND METHODS: Patients with a normal axillary ultrasound or benign core biopsy planned for surgical SLN biopsy were recruited. Part 1 of the study was used to establish the technique of ultrasound microbubble contrast to detect the SLN...
April 17, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28427083/cumulative-risk-of-breast-cancer-screening-outcomes-according-to-the-presence-of-previous-benign-breast-disease-and-family-history-of-breast-cancer-supporting-personalised-screening
#8
M Román, M J Quintana, J Ferrer, M Sala, X Castells
BACKGROUND: Our aim was to assess the cumulative risk of false-positive screening results, screen-detected cancer, and interval breast cancer in mammography screening among women with and without a previous benign breast disease and a family history of breast cancer. METHODS: The cohort included 42 928 women first screened at the age of 50-51 years at three areas of the Spanish Screening Programme (Girona, and two areas in Barcelona) between 1996 and 2011, and followed up until December 2012...
April 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28426344/primary-pediatric-breast-lesions-comparing-the-prevalence-of-malignancies-in-the-middle-east-with-north-america-review-of-1031-cases
#9
Justine S Broecker, Nasim Khoshnam, Laura Thompson, Shady Anis, Nora Kamal, Scott Gillespie, Diana Kantarovich, Diana Metry, Mary Pate Mills, Rachel Drummey, Brianna Williams, Bahig M Shehata
Benign breast masses are uncommon but are becoming more recognized among the pediatric population. Malignant breast lesions are very rare. The aim of our study was to review and compare the demographics, clinical presentation, treatment, and outcomes of breast lesions, including primary malignancies, and to discuss theories that may explain why there is an increased rate of breast cancers diagnosed at a younger age in the Egyptian population. A total of 1031 cases were reviewed. Comparisons were made between the Egyptian (n = 846) and US (n = 185) cohorts...
April 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/28423605/pregnancy-at-early-age-is-associated-with-a-reduction-of-progesterone-responsive-cells-and-epithelial-wnt-signaling-in-human-breast-tissue
#10
Simone Muenst, Robert Mechera, Silvio Däster, Salvatore Piscuoglio, Charlotte K Y Ng, Fabienne Meier-Abt, Walter P Weber, Savas D Soysal
BACKGROUND: Pregnancy at early age is the most significant modifiable factor which consistently decreases lifetime breast cancer risk. However, the underlying mechanisms haven't been conclusively identified. Studies in mice suggest a reduction in progesterone-receptor (PR) sensitive epithelial cells as well as a downregulation of the Wnt signaling pathway as being one of the main mechanisms for the protective effect of early pregnancy. The aim of our study was to validate these findings in humans...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423522/prss3-is-a-prognostic-marker-in-invasive-ductal-carcinoma-of-the-breast
#11
Li Qian, Xiangxiang Gao, Hua Huang, Shumin Lu, Yin Cai, Yu Hua, Yifei Liu, Jianguo Zhang
OBJECTIVE: Serine protease 3 (PRSS3) is an isoform of trypsinogen, and plays an important role in the development of many malignancies. The objective of this study was to determine PRSS3 mRNA and protein expression levels in invasive ductal carcinoma of the breast and normal surrounding tissue samples. RESULTS: Both PRSS3 mRNA and protein levels were significantly higher in invasive ductal carcinoma of the breast tissues than in normal or benign tissues (all P < 0...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422318/computational-analysis-of-breast-cancer-gwas-loci-identifies-the-putative-deleterious-effect-of-stxbp4-and-znf404-gene-variants
#12
Tariq Ahmad Masoodi, Babajan Banaganapalli, Venkatesh Vaidyanathan, Venkateswar Rao Talluri, Noor Ahmad Shaik
The genome-wide association studies (GWAS) have enabled us in identifying different breast cancer susceptibility loci. However, majority of these are non-coding variants with no annotated biological function. We investigated such 78 noncoding genome wide associated SNPs of breast cancer and further expanded the list to 2162 variants with strong linkage-disequilibrium (LD, r2 ≥0.8). Using multiple publically available algorithms such as CADD, GWAVA and FATHAMM, we classified all these variants in to deleterious, damaging or benign categories...
April 19, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28421657/core-outcome-sets-in-women-s-and-newborn-health-a-systematic-review
#13
James M N Duffy, Rachel Rolph, Chris Gale, Martin Hirsch, Khalid S Khan, Sue Ziebland, Richard J McManus
BACKGROUND: Variation in outcome collection and reporting is a serious hindrance to progress in our specialty, over eighty journals have come together to support the development, dissemination, and implementation of core outcome sets. OBJECTIVE: This study systematically reviewed and characterised registered, progressing, or completed core outcome sets relevant to women's and newborn health. SEARCH STRATEGY: Systematic search using the Core Outcome Measures in Effectiveness Trial initiative and the Core Outcomes in Women's and Newborn Health initiative databases...
April 19, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28418338/diagnosis-of-nipple-discharge-value-of-magnetic-resonance-imaging-and-ultrasonography-in-comparison-with-ductoscopy
#14
Ravza Yılmaz, Ömer Bender, Fatma Çelik Yabul, Menduh Dursun, Mehtap Tunacı, Gülden Acunas
BACKGROUND: Pathologic nipple discharge, which is a common reason for referral to the breast imaging service, refers to spontaneous or bloody nipple discharge that arises from a single duct. The most common cause of nipple discharge is benign breast lesions, such as solitary intraductal papilloma and papillomatosis. Nevertheless, in rare cases, a malignant cause of nipple discharge can be found. AIMS: To study the diagnostic value of ultrasonography, magnetic resonance imaging, and ductoscopy in patients with pathologic nipple discharge, compare their efficacy, and investigate the importance of magnetic resonance imaging in the diagnosis of intraductal pathologies...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28417057/evaluation-of-shla-g-levels-in-serum-of-patients-with-prostate-cancer-identify-as-a-potential-of-tumor-marker
#15
Mohammad Hassan Heidari, Abolfazl Movafagh, Mohammad-Amin Abdollahifar, Shabnam Abdi, Mohamadreza Mashhoudi Barez, Hadi Azimi, Afshin Moradi, Amin Bagheri, Matineh Heidari, Jafar Hessam Mohseni, Maryam Tadayon, Hoda Mirsafian, Mahdi Ghatrehsamani
Prostate cancer is the most common cancer type in men and is the second cause of death, due to cancer, in patients over 50, after lung cancer. Prostate specific antigen (PSA) is a widely used tumor marker for prostate cancer. Recently, PSA is discovered in non-prostatic cancer tissues in men and women raising doubts about its specificity for prostatic tissues. PSA exists in low serum level in healthy men and in higher levels in many prostate disorders, including prostatitis and prostate cancer. Thus, a supplementary tumor marker is needed to accurately diagnose the cancer and to observe the patient after treatment...
March 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/28411675/breast-tomosynthesis-practical-considerations
#16
REVIEW
Sarah M Friedewald
Digital breast tomosynthesis (DBT) is rapidly becoming the new standard of care for breast cancer screening. DBT has improved on the limitations of traditional digital mammography by increasing cancer detection and decreasing false-positive examinations. Interpretation of DBT is slightly different than digital mammography and therefore experience with the technology is paramount to achieve best performance. Examples of malignancies that should be recalled and benign findings that are safely called as benign are provided in this article...
May 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28410616/breast-masses-in-mammography-classification-with-local-contour-features
#17
Haixia Li, Xianjing Meng, Tingwen Wang, Yuchun Tang, Yilong Yin
BACKGROUND: Mammography is one of the most popular tools for early detection of breast cancer. Contour of breast mass in mammography is very important information to distinguish benign and malignant mass. Contour of benign mass is smooth and round or oval, while malignant mass has irregular shape and spiculated contour. Several studies have shown that 1D signature translated from 2D contour can describe the contour features well. METHODS: In this paper, we propose a new method to translate 2D contour of breast mass in mammography into 1D signature...
April 14, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28409843/reproducibility-of-quantitative-high-throughput-bi-rads-features-extracted-from-ultrasound-images-of-breast-cancer
#18
Yuzhou Hu, Mengyun Qiao, Yi Guo, Yuanyuan Wang, Jinhua Yu, Jiawei Li, Cai Chang
PURPOSE: Digital Breast Imaging Reporting and Data System (BI-RADS) features extracted from ultrasound images are essential in computer-aided diagnosis, prediction, and prognosis of breast cancer. This study focuses on the reproducibility of quantitative high-throughput BI-RADS features in the presence of variations due to different segmentation results, various ultrasound machine models, and multiple ultrasound machine settings. METHODS: Data set 1 consists of 399 patients with invasive breast cancer and is used as the training set to measure the reproducibility of features, while data set 2 consists of 138 other patients and is a validation set used to evaluate the diagnosis performances of the final reproducible features...
April 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28406095/a-giant-phyllodes-tumor-of-the-breast-causing-severe-disfigurement-a-case-report
#19
Gianluca Franceschini, Danilo Di Giorgio, Sabatino D'Archi, Alba Di Leone, Alejandro Martin Sanchez, Riccardo Masetti
Phyllodes tumours (PTs) are rare fibroepithelial neoplasms representing about 0,2% to 2% of all breast tumors with an incidence of about 2.1 per million. The classification proposed by the World Health Organization for PTs into benign, borderline, and malignant is based on a combination of several histologic features. High-grade malignant phyllodes tumors may spread by hematogenous route. While smaller and moderate size malignant phyllodes may typically be seen, gigantic ones with larger than 10 cm in diameter are very rare...
January 20, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28405083/plasmablastic-plasmacytoma-of-the-breast
#20
Don K Le, David Metter, John R Krause
Breast plasmacytomas are extremely rare entities that can be seen as primary malignant neoplasms in the absence of bone involvement or as secondary neoplasms from disseminated multiple myeloma. Clinicians should be aware of this entity, as it may mimic benign and malignant lesions in the breast. Microscopically, immature plasmacytomas may mimic other neoplasms, so caution should be made on histological examination to ensure the correct diagnosis and corresponding therapy. Here we present a case of a plasmablastic plasmacytoma of the breast in a 55-year-old woman that was originally thought to be an angiosarcoma...
April 2017: Proceedings of the Baylor University Medical Center
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