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https://www.readbyqxmd.com/read/28339285/is-the-necrosis-wall-adc-ratio-useful-for-the-differentiation-of-benign-and-malignant-breast-lesions
#1
Irmak Durur-Subasi, Afak Durur-Karakaya, Adem Karaman, Mehmet Seker, Elif Demirci, Fatih Alper
OBJECTIVES: To determine whether the necrosis/wall apparent diffusion coefficient (ADC) ratio is useful for the malignant-benign differentiation of necrotic breast lesions. METHODS: Breast magnetic resonance imaging (MRI) was performed using a 3T system. In this retrospective study, calculation of the necrosis/wall ADC ratio was based on ADC values measured from the necrosis and from the wall of malignant and benign breast lesions by diffusion-weighted imaging (DWI)...
March 24, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28332304/sclerosing-polycystic-adenosis-a-rare-tumor-misdiagnosed-as-retention-cyst-on-fine-needle-aspiration-cytology
#2
Shilpi, Fuzail Ahmad Ansari, Shalini Bahadur, Akshi Katyal, Aastha Narula, Namrata Nargotra, Sompal Singh
Sclerosing polycystic adenosis (SPA) is a rare benign neoplasm of the salivary gland which resembles the fibrocystic disease of the breast clinically as well as morphologically. This entity has varied morphological presentation on fine needle aspiration. Only a few case reports and occasional case series are found in the literature describing its cytology. Here we are presenting a case of SPA in the parotid gland in a 13-year-old male patient who presented with a slow growing infra-auricular mass since one year without any other symptoms...
March 22, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28332199/investigating-the-feasibility-of-classifying-breast-microcalcifications-using-photon-counting-spectral-mammography-a-simulation-study
#3
Bahaa Ghammraoui, Stephen J Glick
PURPOSE: A dual-energy material decomposition method using photon-counting spectral mammography was investigated as a non-invasive diagnostic approach to differentiate between Type I calcifications, consisting of calcium oxalate dihydrate or weddellite compounds that are more often associated with benign lesions, and Type II calcifications containing hydroxyapatite that are predominantly associated with malignant tumors. METHODS: The study was carried out by numerical simulation to assess the feasibility of the proposed approach...
March 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/28331755/phyllodes-tumor-of-the-breast-analysis-of-48-patients
#4
Murat Özgür Kılıç, Serdar Gökay Terzioğlu, Betül Bozkurt, Gül Dağlar
OBJECTIVE: Phyllodes tumor (PT) is a rare biphasic breast neoplasm that accounts for less than 1% of all breast tumors. The aim of this study was to evaluate the clinicopathologic features, diagnostic difficulties, and therapeutic outcomes of patients with PT. MATERIALS AND METHODS: A total of 48 female patients who underwent surgery for PT were included in the study. Patient characteristics, clinicopathologic features of tumors, diagnostic findings, surgical outcomes, adjuvant therapies, and follow-up findings were retrospectively evaluated...
October 2016: J Breast Health (2013)
https://www.readbyqxmd.com/read/28331748/diagnostic-value-of-diffusion-weighted-imaging-and-apparent-diffusion-coefficient-values-in-the-differentiation-of-breast-lesions-histpathologic-subgroups-and-correlat%C3%A4-on-with-prognost%C3%A4-c-factors-using-3-0-tesla-mr
#5
Yasin Akın, M Ümit Uğurlu, Handan Kaya, Erkin Arıbal
OBJECTIVE: The aim of this study was to evaluate the effect of the apparent diffusion coefficient (ADC) and diffusion-weighted imaging in differentiating benign from malignant breast lesions, histopathologic subtypes of breast tumors, and to find a correlation with prognostic factors using 3T MR. MATERIALS AND METHODS: A total of 165 patients aged between 16 and 78 years with 181 histopathologically-verifed breast lesions were enrolled in this study. A 3T MR system and bilateral phased array breast coil was used...
July 2016: J Breast Health (2013)
https://www.readbyqxmd.com/read/28331240/minimally-invasive-breast-fibroadenoma-excision-using-an-ultrasound-guided-vacuum-assisted-biopsy-device
#6
Thomas Papathemelis, Stefanie Heim, Michael P Lux, Ines Erhardt, Anton Scharl, Sophia Scharl
Introduction We studied the extent to which an ultrasound-guided vacuum-assisted biopsy device ("hand-held Mammotome") could be used not only as a valuable tool for investigation of suspicious breast lesions, but also therapeutically for the complete removal of breast fibroadenomas. Materials and Methods 132 aspiration biopsies showing fibroadenoma on histology were collected retrospectively. We ascertained whether there were residual findings on breast ultrasound at a median follow-up of approx. 9 months following biopsy...
February 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28329541/cowden-syndrome-presenting-with-trichilemmomas
#7
Elise Ng, Vitaly Terushkin, Shane A Meehan, Roger Ho, Miriam Keltz Pomeranz
Cowden syndrome (CS) is a genetic cancerpredisposition syndrome that is associated withgermline mutations in the phosphate and tensinhomologue deleted on chromosome ten (PTEN)tumor suppressor gene. It is characterizedby the formation of benign and malignanttumors. Characteristic benign tumors includetrichilemmommas, acral keratoses, mucocutaneousneuromas, and oral papillomas. The most commonmalignant condition include breast, thyroid, andendometrial cancers. We present a case of a30-year-old woman with CS, who initially presentedwith trichilemmomas that were misdiagnosed ascomedonal acne...
December 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28328843/clinical-significance-of-interval-changes-in-breast-lesions-initially-categorized-as-probably-benign-on-breast-ultrasound
#8
Ja Yoon Jang, Sun Mi Kim, Jin Hwan Kim, Mijung Jang, Bo La Yun, Jong Yoon Lee, Soo Hyun Lee, Bohyoung Kim
The aims of this study were to determine the malignancy rate of probably benign lesions that show an interval change on follow-up ultrasound and to evaluate the differences seen on imaging between benign and malignant lesions initially categorized as probably benign but with interval change on follow-up breast ultrasound.We retrospectively reviewed 11,323 lesions from ultrasound-guided core-biopsies performed between June 2004 and December 2014 and identified 289 lesions (266 patients) with an interval change from probably benign (Breast Imaging Reporting and Data System [BI-RADS] category 3) in the previous 2 years...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28327449/integrated-local-binary-pattern-texture-features-for-classification-of-breast-tissue-imaged-by-optical-coherence-microscopy
#9
Sunhua Wan, Hsiang-Chieh Lee, Xiaolei Huang, Ting Xu, Tao Xu, Xianxu Zeng, Zhan Zhang, Yuri Sheikine, James L Connolly, James G Fujimoto, Chao Zhou
This paper proposes a texture analysis technique that can effectively classify different types of human breast tissue imaged by Optical Coherence Microscopy (OCM). OCM is an emerging imaging modality for rapid tissue screening and has the potential to provide high resolution microscopic images that approach those of histology. OCM images, acquired without tissue staining, however, pose unique challenges to image analysis and pattern classification. We examined multiple types of texture features and found Local Binary Pattern (LBP) features to perform better in classifying tissues imaged by OCM...
March 8, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28322032/fine-needle-aspiration-of-metastatic-melanoma-presenting-as-bilateral-breast-cysts
#10
Casey M Inouye, Ashley Cimino-Mathews, David Eisner, Dorothy L Rosenthal, Christopher J VandenBussche
Melanoma is the second most common non-hematopoietic malignancy after carcinomas to metastasize to the breast and often appears as a well-circumscribed, dense nodule on imaging. Although metastatic lesions presenting as bilateral cysts have been reported, this presentation is not common and may mimic benign breast cysts. We present a challenging case of metastatic melanoma presenting as bilateral breast cysts with spindled cytomorphology in a patient with a history of mammary carcinoma. Discordance between the spindled cytomorphology and the morphology of the core biopsy, which was similar to the patient's primary breast cancer, allowed for entertainment of other tumors and disease processes...
March 20, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28306620/diagnostic-performance-of-a-novel-dedicated-breast-pet-scanner-with-c-shaped-ring-detectors
#11
Ryusuke Nakamoto, Yuji Nakamoto, Takayoshi Ishimori, Kayo Nishimatsu, Kanae K Miyake, Shotaro Kanao, Mami Iima, Masakazu Toi, Kaori Togashi
BACKGROUND: A dedicated breast PET scanner with C-shaped detectors (C scanner) has been newly developed. The purpose of this study was to re-evaluate the diagnostic performance of high-resolution PET images with the new reconstruction conditions, obtained using this C scanner in breast cancer patients, and to compare the standardized uptake values (SUVs) of lesions obtained from the C scanner with those from whole-body PET/computed tomography (CT) (WB PET/CT). PATIENTS AND METHODS: A total of 159 female patients with known or suspected breast carcinomas (total 188 lesions: 172 invasive carcinomas; eight noninvasive ductal carcinomas in situ; eight benign lesions) were analysed...
March 16, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28301207/second-opinion-review-of-breast-imaging-at-a-cancer-center-is-it-worthwhile
#12
Kristen Coffey, Donna D'Alessio, Delia M Keating, Elizabeth A Morris
OBJECTIVE: Second-opinion review of breast imaging studies can be a time-consuming and labor-intensive process. The purpose of this investigation was to determine whether reinterpretation of studies obtained at institutions outside a cancer center influences clinical management, specifically by revealing additional cancer and preventing unnecessary biopsy. MATERIALS AND METHODS: A review was conducted of breast imaging studies of 200 patients who underwent ultrasound and MRI at community facilities and had the images submitted for second opinions at a cancer center between January and April 2014...
March 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28299890/a-case-of-adenomyoepithelioma-of-the-breast-showing-strong-uptake-of-18-f-fluorodeoxyglucose-on-a-positron-emission-tomography
#13
Takaaki Oba, Kazuma Maeno, Mayu Ono, Asumi Iesato, Tokiko Ito, Toshiharu Kanai, Yasuhiro Mochizuki, Ken-Ichi Ito, Akihiko Yoshizawa, Fumiyoshi Takayama
An adenomyoepithelioma of the breast is a rare tumor characterized by biphasic proliferation of both epithelial and myoepithelial cells. This tumor is generally considered as a benign neoplasm, and there are few reports describing the imaging features of this tumor through (18) F-fluorodeoxyglucose positron emission tomography (FDG-PET). Here, we report a case of an adenomyoepithelioma that showed strong uptake of FDG on PET similar to that observed with a malignant tumor. A 73-year-old woman presented to our hospital with a 3...
March 2017: Breast Journal
https://www.readbyqxmd.com/read/28299887/fibroepithelial-lesions-in-the-breast-of-adolescent-females-a-clinicopathological-study-of-54-cases
#14
Dara S Ross, Dilip D Giri, Muzaffar M Akram, Jeffrey P Catalano, Cristina Olcese, Kimberly J Van Zee, Edi Brogi
Fibroepithelial lesions (FELs) are the most frequent breast tumors in adolescent females. The pubertal hormonal surge could impact the growth and microscopic appearance of FELs in this age group. In this study, we evaluate the morphology and clinical behavior of FELs in adolescents. We searched the 1992-2012 pathology data base for FELs in females 18 years old or younger (F ≤18 years). Seven FELs from 1975 to 1983 were also included. Three pathologists reviewed all available material. Patient (pt) characteristics and follow-up information were obtained from electronic medical records...
March 2017: Breast Journal
https://www.readbyqxmd.com/read/28296665/papillomas-of-the-breast-factors-associated-with-underestimation
#15
Gabriela Boufelli, Marcelo A Giannotti, Carlos A Ruiz, Nestor de Barros, Luciano F Chala, Jonathan Y Maesaka, Rodrigo Goncalves, Bárbara H Bresciani, Paula Vianna, José M Soares, Edmund C Baracat, José R Filassi
The distinction between benign and malignant papilloma of the breast through percutaneous needle biopsy can be difficult because of limited samples; the underestimation rate can be up to 25%. The aim of this study is to identify clinical and histological factors associated with underestimation, invasive ductal carcinoma, or ductal in-situ carcinoma (DCIS) of the breast found in surgical specimens from papillary lesions. This may contribute toward selection of patients for a follow-up strategy without the need for surgical excision...
March 14, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28295467/ultrasound-strain-elastography-for-breast-lesions-computer-aided-evaluation-with-quantifiable-elastographic-features
#16
Yang Xiao, Jie Zeng, Xue Zhang, Li-Li Niu, Ming Qian, Cong-Zhi Wang, Hai-Rong Zheng, Rong-Qin Zheng
OBJECTIVES: To develop and evaluate a set of quantifiable elastographic features based on ultrasound real-time strain elastography (SE) in differentiating between benign and malignant breast lesions. METHODS: The SE and conventional B-mode ultrasound images of 226 breast lesions (81 malignant, 145 benign) were obtained from 226 consecutive women. By using a computer-aided tool, four elastographic features (elasticity score, lesion stiffness degree, lesion-to-fat strain ratio, and elastography-to-B-mode lesion area ratio) were respectively calculated and evaluated...
March 10, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28295405/optimal-reconstruction-and-quantitative-image-features-for-computer-aided-diagnosis-tools-for-breast-ct
#17
Juhun Lee, Robert M Nishikawa, Ingrid Reiser, John M Boone
PURPOSE: The purpose of this study is to determine the optimal representative reconstruction and quantitative image feature set for a computer-aided diagnosis (CADx) scheme for dedicated breast computer tomography (bCT). METHOD: We used 93 bCT scans that contain 102 breast lesions (62 malignant, 40 benign). Using an iterative image reconstruction (IIR) algorithm, we created 37 reconstructions with different image appearances for each case. In addition, we added a clinical reconstruction for comparison purposes...
March 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/28295287/design-considerations-for-identifying-breast-cancer-risk-factors-in-a-population-based-study-in-africa
#18
Louise A Brinton, Baffour Awuah, Joe Nat Clegg-Lamptey, Beatrice Wiafe-Addai, Daniel Ansong, Kofi M Nyarko, Seth Wiafe, Joel Yarney, Richard Biritwum, Michelle Brotzman, Andrew A Adjei, Ernest Adjei, Francis Aitpillah, Lawrence Edusei, Florence Dedey, Sarah J Nyante, Joseph Oppong, Ernest Osei-Bonsu, Nicholas Titiloye, Verna Vanderpuye, Emma Brew Abaidoo, Bernard Arhin, Isaac Boakye, Margaret Frempong, Naomi Ohene Oti, Victoria Okyne, Jonine D Figueroa
Although breast cancer is becoming more prevalent in Africa, few epidemiologic studies have been undertaken and appropriate methodologic approaches remain uncertain. We therefore conducted a population-based case-control study in Accra and Kumasi, Ghana, enrolling 2,202 women with lesions suspicious for breast cancer and 2,161 population controls. Biopsy tissue for cases prior to neoadjuvant therapy (if given), blood, saliva and fecal samples were sought for study subjects. Response rates, risk factor prevalences, and odds ratios (OR) for established breast cancer risk factors were calculated...
March 13, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28295007/-anogenital-mammary-like-glands-and-related-lesions-part-1-benign-tumors-and-tumor-like-disorders
#19
A M Konstantinova, I E Belousova, D Katserovska, M Mikhal, K V Shelekhova, D V Kazakov
Anogenital mammary-like glands represent a normal anatomic constituent of the anogenital area and may give rise to many benign and malignant tumors that morphologically mimic similar breast diseases. The literature review is complemented by a description of 286 cases of benign tumors and tumor-like processes in the mammary-like glands. The paper presents the clinical and morphological characteristics of papillary hidradenoma, fibroadenoma, benign phyllodes tumor, lactating adenoma, sclerosing adenosis, pseudoangiomatous stromal hyperplasia, etc...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28291391/ultrasound-molecular-imaging-with-br55-in-patients-with-breast-and-ovarian-lesions-first-in-human-results
#20
Jürgen K Willmann, Lorenzo Bonomo, Antonia Carla Testa, Pierluigi Rinaldi, Guido Rindi, Keerthi S Valluru, Gianluigi Petrone, Maurizio Martini, Amelie M Lutz, Sanjiv S Gambhir
Purpose We performed a first-in-human clinical trial on ultrasound molecular imaging (USMI) in patients with breast and ovarian lesions using a clinical-grade contrast agent (kinase insert domain receptor [KDR] -targeted contrast microbubble [MBKDR]) that is targeted at the KDR, one of the key regulators of neoangiogenesis in cancer. The aim of this study was to assess whether USMI using MBKDR is safe and allows assessment of KDR expression using immunohistochemistry (IHC) as the gold standard. Methods Twenty-four women (age 48 to 79 years) with focal ovarian lesions and 21 women (age 34 to 66 years) with focal breast lesions were injected intravenously with MBKDR (0...
March 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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