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https://www.readbyqxmd.com/read/29327953/multicentric-cryptococcosis-in-a-congo-african-grey-parrot-psittacus-erithacus-erithacus
#1
Raina S K Schunk, Nicholas E Sitinas, Katherine E Quesenberry, Jessica L Grodio
An approximately 10-year-old, female Congo African grey parrot ( Psittacus erithacus erithacus) developed progressive, unilateral exophthalmos and buphthalmos. Survey radiographs revealed a large, coelomic, soft tissue mass, which was confirmed on computed tomography scan. Aspirates of both the contents of the buphthalmic globe and coelomic mass were consistent with Cryptococcus species. Initial results were later confirmed with serum antigen latex agglutination and polymerase chain reaction testing, and the organism was then identified as Cryptococcus neoformans with DNA sequencing...
December 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29325509/terbinafine-hydrochloride-nail-lacquer-for-the-management-of-onychomycosis-formulation-characterization-and-in-vitro-evaluation
#2
Purva Thatai, Bharti Sapra
AIM: The present investigation's intention was to develop an optimized nail lacquer (NL) for the management of onychomycosis. MATERIALS & METHODS: The NL was optimized statistically adopting 32 full factorial design having different polymer ratios and solvent ratios. The formulations were assessed for drug permeation drying time and peak adhesive strength of the film. Characterization was done using techniques including attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), x-ray diffraction (XRD), etc...
February 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29325167/a-multicentre-study-of-antifungal-susceptibility-patterns-among-350-candida-auris-isolates-2009-17-in-india-role-of-the-erg11-and-fks1-genes-in-azole-and-echinocandin-resistance
#3
Anuradha Chowdhary, Anupam Prakash, Cheshta Sharma, Milena Kordalewska, Anil Kumar, Smita Sarma, Bansidhar Tarai, Ashutosh Singh, Gargi Upadhyaya, Shalini Upadhyay, Priyanka Yadav, Pradeep K Singh, Vikas Khillan, Neelam Sachdeva, David S Perlin, Jacques F Meis
Background: Candida auris has emerged globally as an MDR nosocomial pathogen in ICU patients. Objectives: We studied the antifungal susceptibility of C. auris isolates (n = 350) from 10 hospitals in India collected over a period of 8 years. To investigate azole resistance, ERG11 gene sequencing and expression profiling was conducted. In addition, echinocandin resistance linked to mutations in the C. auris FKS1 gene was analysed. Methods: CLSI antifungal susceptibility testing of six azoles, amphotericin B, three echinocandins, terbinafine, 5-flucytosine and nystatin was conducted...
January 9, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29286021/toenail-onychomycosis-by-trichophyton-rubrum-and-concurrent-infestation-with-tyrophagus-putrescentiae
#4
Valentina Fabrizi, Ivana Zacconi, Mario Principato, Cristina Pesca, Deborah Cruciani, Silvia Crotti, Manuela Papini
A remarkable case of onychomycosis by Trichophyton (T.) rubrum combined with nail infestation by Tyrophagus (T.) putrescentiae in an elderly diabetic farmer is described and discussed. Large numbers of eggs and mites in all development stages were present in nail debris, reflecting active reproduction on site. Treatment with ivermectin 0.1% cream and environmental decontamination cleared the mite infestation, while onychomycosis responded well to oral terbinafine and ciclopirox 8% nail lacquer. Such a combination of onychomycosis and mite infestation of the same nail is an exceptional finding reported only twice in the literature...
December 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29227694/pulsed-electric-field-assisted-sensitization-of-multidrug-resistant-candida-albicans-to-antifungal-drugs
#5
Vitalij Novickij, Jurgita Švedienė, Algimantas Paškevičius, Svetlana Markovskaja, Irutė Girkontaitė, Auksė Zinkevičienė, Eglė Lastauskienė, Jurij Novickij
AIM: Determine the influence of pH on the inactivation efficiency of C. albicans in pulsed electric fields (PEF) and evaluate the possibilities for sensitization of a drug-resistant strain to antifungal drugs. MATERIALS & METHODS: The effects of PEF (2.5-25 kVcm-1) with fluconazole, terbinafine and naftifine were analyzed at a pH range of 3.0-9.0. Membrane permeabilization was determined by flow cytometry and propidium iodide. RESULTS: PEF induced higher inactivation of C...
December 11, 2017: Future Microbiology
https://www.readbyqxmd.com/read/29222709/successful-treatment-of-canine-sporotrichosis-with-terbinafine-case-reports-and-literature-review
#6
Paula Gonçalves Viana, Anna Barreto Fernandes Figueiredo, Isabella Dib Ferreira Gremião, Luisa Helena Monteiro de Miranda, Isabela Maria da Silva Antonio, Jéssica Sepulveda Boechat, Ana Caroline de Sá Machado, Manoel Marques Evangelista de Oliveira, Sandro Antonio Pereira
Sporotrichosis occurs worldwide, and the metropolitan region of Rio de Janeiro, Brazil, is a main endemic area, with a large number of human and animal cases in the last 19 years. This mycosis is more frequently described in cats rather than in dogs. There are a limited number of oral antifungal agents for the treatment of sporotrichosis in animals. In this context, the effectiveness of terbinafine in the treatment of sporotrichosis in humans, as well as the promising results of in vitro susceptibility tests, inspired us to use this drug in the therapy of this mycosis in dogs...
December 8, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29206346/novel-approaches-to-antifungal-therapy
#7
EDITORIAL
George R Thompson, Thomas F Patterson
Invasive fungal infections remain a major cause of morbidity and mortality in the solid organ transplant population. Non-Aspergillus infections are of particular concern due to the reduced antifungal susceptibility of many of these fungi (Scedopsorium, Lomentospora, Fusarium etc), the difficulty in distinguishing these organisms from Aspergillus spp based on histopathology alone, and the higher associated mortality observed with these organisms. Current treatment options for these fungi are limited, and voriconazole is the most commonly recommended primary agent1, 2 with combination therapy (terbinafine or an echinocandin) also recommended by some experts...
December 5, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29204393/lymphocutaneous-sporotrichosis-treated-with-potassium-iodide-with-development-of-subclinical-hypothyroidism-wolff-chaikoff-effect
#8
Pooja Arora, M Raihan, Asha Kubba, Ram K Gautam
Sporotrichosis is a subcutaneous mycotic infection caused by Sporothrix schenckii that is acquired by traumatic implantation. The diagnosis is established by demonstration of fungal elements on histopathology and culture. Potassium iodide, azole antifungals, and terbinafine are the treatment options available. In this article, we report a 60-year-old female with lymphocutaneous sporotrichosis that responded well to potassium iodide. However, subclinical hypothyroidism (Wolff-Chaikoff effect) was encountered as a side effect of therapy which was managed with thyroxine replacement...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29204336/sporotrichosis-by-sporothrix-schenckii-senso-stricto-with-itraconazole-resistance-and-terbinafine-sensitivity-observed-in-vitro-and-in-vivo-case-report
#9
Rodrigo Vettorato, Daiane Heidrich, Fernanda Fraga, Amanda Carvalho Ribeiro, Danielle Machado Pagani, Carina Timotheo, Tais Guarienti Amaro, Gerson Vettorato, Maria Lúcia Scroferneker
We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29188282/laboratory-monitoring-during-systemic-terbinafine-therapy-for-pediatric-onychomycosis
#10
Deepa Patel, Leslie A Castelo-Soccio, Adam I Rubin, Jenna L Streicher
No abstract text is available yet for this article.
December 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29178398/successful-treatment-of-chromoblastomycosis-of-10-year-duration-due-to-fonsecaea-nubica
#11
Liya He, Jianchi Ma, Xin Mei, Sha Lu, Xiqing Li, Liyan Xi
We report a case of chromoblastomycosis due to presence of large plaque and verrucous hyperplasia lesions on the left upper limb, with elbow abnormal activities, in a 56-year-old male. The diagnosis of chromoblastomycosis was based on gross and microscopic morphologies, histopathological examination and clinical manifestation. Molecular tools were applied to identifying the causative agent: Fonsecaea nubica, which is rarely reported to be associated with chromoblastomycosis. The patient was initially treated orally with terbinafine (250 mg/day) and itraconazole (200 mg/day), subsequently patient received thermotherapy (45-50 °C, 3 hours/day) for one month...
November 25, 2017: Mycoses
https://www.readbyqxmd.com/read/29177053/evaluation-of-a-single-administration-ototopical-treatment-for-canine-otitis-externa-a-randomised-trial
#12
John Blake, Daniel Keil, Kenneth Kwochka, Kathleen Palma, Jennifer Schofield
Objective: To evaluate the efficacy and safety of a new, single-administration Otic Solution containing florfenicol, terbinafine and mometasone furoate for the treatment of canine otitis externa (OE). Design: The clinical efficacy and safety study was a multicentre, controlled, masked and randomised field study conducted over 30 days. Two hundred and twenty-one (221) client-owned dogs of varying breeds with diagnosed bacterial and/or fungal OE were enrolled. Procedure: Dogs were randomised to either Otic Solution or control groups...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/29164434/isolated-cutaneous-granuloma-caused-by-candida-glabrata-a-rare-case-report-and-literature-review
#13
REVIEW
Yibin Fan, Weili Pan, Guizhen Wang, Youming Huang, Yali Li, Wei Fang, Xiaohua Tao
The incidence of candidiasis due to non-albicans Candida species (especially Candida glabrata) has significantly increased in recent decades. Candida glabrata often invades immunocompromised hosts and causes systemic or mucosal infections, whereas cutaneous infections are rarely reported. We present a rare case of cutaneous infection caused by C. glabrata and review all similar cases available in the PubMed database. A patient was admitted to the hospital with a 2-month history of a plaque on the face. Histopathological examination displayed typical infectious granulomas in the deep dermis, and the pathogen was finally confirmed as C...
November 22, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29147866/a-review-of-onychomycosis-due-to-aspergillus-species
#14
REVIEW
Felix Bongomin, C R Batac, Malcolm D Richardson, David W Denning
Aspergillus spp. are emerging causative agents of non-dermatophyte mould onychomycosis (NDMO). New Aspergillus spp. have recently been described to cause nail infections. The following criteria are required to diagnose onychomycosis due to Aspergillus spp.: (1) positive direct microscopy and (2) repeated culture or molecular detection of Aspergillus spp., provided no dermatophyte was isolated. A review of 42 epidemiological studies showed that onychomycosis due to Aspergillus spp. varies between < 1 and 35% of all cases of onychomycosis in the general population and higher among diabetic populations accounting for up to 71% and the elderly; it is very uncommon among children and adolescence...
November 16, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29120502/necrotizing-microascus-tracheo-bronchitis-in-a-bilateral-lung-transplant-recipient
#15
Olivier Taton, Benjamin Bernier, Isabelle Etienne, Benjamin Bondue, Sophie Lecomte, Christiane Knoop, Frederique Jacob, Isabel Montesinos
Invasive fungal infections are a major cause of mortality among solid organ transplant recipients. Scopulariopsis species and their teleomorph Microascus are molds found in soil and decaying organic matter. We report here the case of a woman who underwent bilateral lung transplantation for severe emphysema. On day 25 after transplantation, endobronchial green-black lesions were detected during routine endoscopy. Endobronchial swabs, biopsies, and broncho-alveolar lavage samples were positive for Microascus cirrosus...
November 9, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29116676/salvage-therapy-with-topical-posaconazole-in-lung-transplant-recipients-with-invasive-scedosporium-infection
#16
Amparo Solé, Ana A García-Robles, Carlos Jordá, Enrique Cases Viedma, Nuria Mancheño, José Luis Poveda-Andrés, Juan Pablo Reig Mezquida, Javier Pemán
Scedosporium is an important pathogen in cystic fibrosis (CF) and post-transplant, but it rarely causes invasive infection. Treatment remains challenging, particularly due to the inherent resistance to multiple antifungal agents. We present three complicated invasive tracheobronchial and lung Scedosporium apiospermum infections following lung transplant. In two of three cases, the infection was clinically and radiologically cured with frequent cleansing bronchoscopies, combining triazole with terbinafine therapy and nebulized posaconazole...
November 8, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29110252/risk-of-psoriasis-following-terbinafine-or-itraconazole-treatment-for-onychomycosis-a-population-based-case-control-comparative-study
#17
Hsien-Yi Chiu, Wei-Lun Chang, Tsen-Fang Tsai, Yi-Wen Tsai, Ming-Neng Shiu
INTRODUCTION: Several case studies have reported an association between antifungal drug use and psoriasis risk. OBJECTIVE: The objective of this study was to investigate the association between terbinafine/itraconazole exposure and psoriasis incidence. METHODS: Among patients with onychomycosis in the Taiwan National Health Insurance Research Database, 3831 incident psoriasis cases were identified during 2004-2010 and compared with 3831 age- and sex-matched controls with the same look-back period...
November 6, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29102309/challenges-in-culture-negative-cases-of-madurella-mycetomatis-a-case-report-re-accentuating-pcr-as-an-essential-diagnostic-tool
#18
S K, S Das, D Pandhi, G Rai, M A Ansari, C Gupta, S Haque, S A Dar
Identification of dematiaceous fungi responsible for black-grain mycetoma has remained cumbersome and time consuming for years leading to delayed diagnosis and thereby increased agony to patients. Moreover, difficult morphology of some of these fungi demanding enough expertise for species identification in addition to culture-negativity has often led to misdiagnosis and hence inapt treatment to the patients. We report the identification of Madurella mycetomatis from culture-negative black granules discharged from foot nodular lesions of a 27 years old male using PCR followed by sequencing of the internal transcribed spacer region...
October 25, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29094463/severe-dermatophytosis-in-solid-organ-transplant-recipients-a-french-retrospective-series-and-literature-review
#19
Claire Rouzaud, Olivier Chosidow, Anabelle Brocard, Sylvie Fraitag, Anne Scemla, Dany Anglicheau, Jean-David Bouaziz, Nicolas Dupin, Marie-Elisabeth Bougnoux, Roderick Hay, Olivier Lortholary, Fanny Lanternier
OBJECTIVE: Severe dermatophytosis is described in immunocompromised patients with defective cellular immunity. We report here a large series and a literature review of severe dermatophytosis in solid organ transplant (SOT) recipients. METHOD: The data main source was a national French retrospective study of severe dermatophytosis in SOT recipients between 2010 and 2016. Inclusion criteria were the presence of dermatophytes in skin culture and one severity criteria: dermal invasion by dermatophytes (invasive dermatophytosis) or involvement of at least two body sites or >10% of body surface area (extensive dermatophytosis) RESULTS: Twelve patients were included (8 men, median age of 56 years [range: 33-71])...
November 2, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29082569/deep-facial-mycosis-due-to-trichophyton-verrucosum-molecular-genetic-identification-of-the-dermatophyte-in-paraffin-embedded-tissue-case-report-and-review-of-the-literature
#20
REVIEW
U Wollina, G Hansel, S Uhrlaß, C Krüger, J Schönlebe, U-C Hipler, P Nenoff
Deep trichophytosis is relatively uncommon. The infection of the bearded area is also known as sycosis barbae or tinea barbae and can be caused by various fungal species, most often zoophilic fungi. We report on an 80-year-old male patient with severe sycosis barbae who had no animal contact and was treated with systemic antibiosis without improvement. Microbial and mycological investigations using swabs from oozing lesions revealed Staphylococcus hemolyticus and Candida parapsilosis. Histology demonstrated fungal elements in hair follicles...
October 30, 2017: Mycoses
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