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https://www.readbyqxmd.com/read/28317391/in-vitro-inhibitory-effects-of-farnesol-and-interactions-between-farnesol-and-antifungals-against-biofilms-of-candida-albicans-resistant-strains
#1
Jinping Xia, Fang Qian, Wenqian Xu, Zhenzhen Zhang, Xin Wei
Antifungal resistance is a serious problem in clinical infections. Farnesol, which is a potential antifungal agent against biofilms formed by Candida albicans resistant strains (a fluconazole-resistant isolate derived from SC5314 and two clinical Candida resistant isolates), was investigated in this study. The inhibitory effects of farnesol on biofilms were examined by XTT assay. The morphological changes and biofilm thicknesses were analyzed by scanning electron microscopy and confocal laser scanning microscopy, respectively...
March 20, 2017: Biofouling
https://www.readbyqxmd.com/read/28295766/impact-of-a-terbinafine-florfenicol-betamethasone-acetate-otic-gel-on-the-quality-of-life-of-dogs-with-acute-otitis-externa-and-their-owners
#2
Chiara Noli, Roberta Sartori, Tiziana Cena
BACKGROUND: Treatment of canine otitis externa with owner-administered products can be difficult. OBJECTIVES: To evaluate otic treatment administered by a veterinarian on quality of life (QoL) of dogs with otitis externa and their owners, and on clinical and cytology parameters of otitis; compared to an owner-administered treatment. ANIMALS: Fifty client-owned dogs randomly randomized into two groups and treated for 2 weeks. METHODS: Veterinarians treated Group A dogs with a veterinary licensed otic gel on two occasions at a 1 week interval; owners treated Group B dogs once daily with a veterinary licensed otic drop based product along with twice weekly cleaning...
March 15, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28281037/pathogenic-dermatophytes-survive-in-nail-lesions-during-oral-terbinafine-treatment-for-tinea-unguium
#3
Tomoyuki Iwanaga, Tsuyoshi Ushigami, Kazushi Anzawa, Takashi Mochizuki
Tinea unguium caused by dermatophyte species are usually treated with oral antimycotic, terbinafine (TBF). To understand the mechanisms of improvement and recalcitrance of tinea unguium by oral TBF treatment, a method of quantifying dermatophyte viability in the nail was developed, and the viability of dermatophytes was analyzed in toenail lesions of 14 patients with KOH-positive tinea unguium treated with oral TBF 125 mg/day for up to 16 weeks. Mycological tests, including KOH examination and fungal culture, and targeted quantitative real-time PCR for internal transcribed spacer (ITS) region, including rRNA, were demonstrated at the initial visit and after 8 and 16 weeks of treatment...
March 9, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28275534/disseminated-phaeohyphomycosis-in-a-dog
#4
Lana S Rothenburg, Timothy A Snider, Allison Wilson, Anthony W Confer, Akhilesh Ramachandran, Rinosh Mani, Theresa Rizzi, Laura Nafe
Phaeohyphomycosis is a rare but emerging disease caused by dematiaceous fungi. Here we describe the case of an immunosuppressed dog with disseminated phaeohyphomycosis secondary to Bipolaris spicifera infection. Regionally extensive infiltration of the paw pads, skin, myocardium, liver, renal interstitium and diaphragm was identified on histopathology. Candida glabrata and Fusarium oxysporum were also cultured from multiple sites post-mortem. The dog was treated with fluconazole, itraconazole, terbinafine and liposomal amphotericin B, but was euthanized due to its poor prognosis after 12 days of therapy...
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28272341/liver-effects-of-clinical-drugs-differentiated-in-human-liver-slices
#5
Alison E M Vickers, Anatoly V Ulyanov, Robyn L Fisher
Drugs with clinical adverse effects are compared in an ex vivo 3-dimensional multi-cellular human liver slice model. Functional markers of oxidative stress and mitochondrial function, glutathione GSH and ATP levels, were affected by acetaminophen (APAP, 1 mM), diclofenac (DCF, 1 mM) and etomoxir (ETM, 100 μM). Drugs targeting mitochondria more than GSH were dantrolene (DTL, 10 μM) and cyclosporin A (CSA, 10 μM), while GSH was affected more than ATP by methimazole (MMI, 500 μM), terbinafine (TBF, 100 μM), and carbamazepine (CBZ 100 μM)...
March 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28263845/new-polyurethane-nail-lacquers-for-the-delivery-of-terbinafine-formulation-and-antifungal-activity-evaluation
#6
Barbara S Gregorí Valdes, Ana Paula Serro, Paulo M Gordo, Alexandra Silva, Lídia Gonçalves, Ana Salgado, Joana Marto, Diogo Baltazar, Rui Galhano Dos Santos, João Moura Bordado, Helena Margarida Ribeiro
Onychomycosis is a fungal nail infection. The development of new topical antifungal agents for the treatment of onychomycosis has focused on formulation enhancements that optimize the pharmacological characteristics required for its effective treatment. Polyurethanes (PUs) have never been used in therapeutic nail lacquers. The aim of this work has been the development of new PU based nail lacquers with antifungal activity containing 1.0% (w/w) of terbinafine hydrochloride. The biocompatibility, wettability and the prediction of the free volume in the polymeric matrix were assessed using a human keratinocytes cell line, contact angle and Positron Annihilation Lifetime Spectroscopy (PALS) determinations, respectively...
March 2, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28261269/comparative-hepatotoxicity-of-fluconazole-ketoconazole-itraconazole-terbinafine-and-griseofulvin-in-rats
#7
Star Khoza, Ishmael Moyo, Denver Ncube
Oral ketoconazole was recently the subject of regulatory safety warnings because of its association with increased risk of inducing hepatic injury. However, the relative hepatotoxicity of antifungal agents has not been clearly established. The aim of this study was to compare the hepatotoxicity induced by five commonly prescribed oral antifungal agents. Rats were treated with therapeutic oral doses of griseofulvin, fluconazole, itraconazole, ketoconazole, and terbinafine. After 14 days, only ketoconazole had significantly higher ALT levels (p = 0...
2017: Journal of Toxicology
https://www.readbyqxmd.com/read/28211348/psoriatic-erythroderma-caused-by-terbinafine-a-possible-pathogenetic-role-for-il-23
#8
T Oda, Y Sawada, T Yamaguchi, S Ohmori, D Omoto, S Haruyama, M Yoshioka, E Okada, M Nakamura
No abstract text is available yet for this article.
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28196318/common-skin-conditions-in-children-skin-infections
#9
Brian Z Rayala, Dean S Morrell
Skin infections account for a significant subset of dermatologic conditions of childhood. Common cutaneous viral infections in children include warts, molluscum contagiosum, hand-foot-and-mouth disease, and herpes simplex. Although viral infections are self-limited and often only mildly symptomatic, they can cause anxiety, embarrassment, and health care use. Recognition of their common and atypical presentations is necessary to differentiate them from other skin conditions of similar morphology. Impetigo, cellulitis, and abscess comprise the majority of childhood bacterial skin infections and are treated with topical or systemic antibiotics that cover group A Streptococcus and Staphylococcus aureus...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28192433/review-of-21-cases-of-mycetoma-from-1991-to-2014-in-rio-de-janeiro-brazil
#10
Felipe Maurício Soeiro Sampaio, Bodo Wanke, Dayvison Francis Saraiva Freitas, Janice Mery Chicarino de Oliveira Coelho, Maria Clara Gutierrez Galhardo, Marcelo Rosandiski Lyra, Maria Cristina da Silva Lourenço, Rodrigo de Almeida Paes, Antonio Carlos Francesconi do Valle
Mycetoma is caused by the subcutaneous inoculation of filamentous fungi or aerobic filamentous bacteria that form grains in the tissue. The purpose of this study is to describe the epidemiologic, clinic, laboratory, and therapeutic characteristics of patients with mycetoma at the Oswaldo Cruz Foundation in Rio de Janeiro, Brazil, between 1991 and 2014. Twenty-one cases of mycetoma were included in the study. There was a predominance of male patients (1.3:1) and the average patient age was 46 years. The majority of the cases were from the Southeast region of Brazil and the feet were the most affected anatomical region (80...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28183589/terbinafine-loaded-wound-dressing-for-chronic-superficial-fungal-infections
#11
Farnoush Asghari Paskiabi, Shahin Bonakdar, Mohammad Ali Shokrgozar, Mohammad Imani, Zahra Jahanshiri, Masoomeh Shams-Ghahfarokhi, Mehdi Razzaghi-Abyaneh
In spite of developing new drugs and modern formulations, the treatments of chronic fungal infections are still challenging. Fibrous wound dressings are new suggestions for the treatment of chronic superficial infections. In the present study, we formulated an antifungal agent, terbinafine hydrochloride (TFH), which is a hydrophobic drug, in wound dressings prepared by electrospun polycaprolactone, polycaprolactone/gelatin (50:50 w/w) and gelatin. To obtain more water-stable meshes, the preparations were treated by glutaraldehyde and their properties were determined before and after treatment...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28139861/species-diversity-antifungal-susceptibility-and-phenotypic-and-genotypic-characterisation-of-exophiala-spp-infecting-patients-in-different-medical-centres-in-brazil
#12
Wendy C Silva, Sarah S Gonçalves, Daniel W C L Santos, Ana Carolina B Padovan, Fernando C Bizerra, Analy S A Melo
The Exophiala genus is responsible for many superficial and invasive infections resulting from black fungi. Identification of Exophiala at the species level is based on morphological observations complemented by molecular tests. The aim of this study was to identify 23 clinical isolates of Exophiala spp. and evaluate the antifungal susceptibility to seven different agents. Molecular identification was based on an analysis of ITS region of rDNA using genomic databases. The micromorphology was evaluated by microculture and scanning electron microscopy...
January 31, 2017: Mycoses
https://www.readbyqxmd.com/read/28133872/comparison-of-two-in%C3%A2-vitro-antifungal-sensitivity-tests-and-monitoring-during-therapy-of-sporothrix-schenckii-sensu-stricto-in-malaysian-cats
#13
Hock Siew Han, Rui Kano, Charles Chen, Chiara Noli
BACKGROUND: Feline sporotrichosis is common in Malaysia. Thermosensitivity and effects of azole treatment on fungal susceptibility are unknown. OBJECTIVES: To evaluate thermotolerance and antifungal susceptibility of feline Malaysian Sporothrix isolates, compare microdilution (MD) and E-test results, and investigate changes in susceptibility during azole therapy. METHODS: Sporothrix schenckii sensu stricto was isolated from 44 cats. Thermotolerance was determined via culture at 37°C for 7 days...
February 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28128088/gestational-pityriasis-rosea-suggestions-for-approaching-affected-pregnant-women
#14
Alexandra Monastirli, Efstathia Pasmatzi, George Badavanis, Dionysios Tsambaos
Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7 (1). It predominantly affects individuals of both sexes in their second or third decade of life and is clinically characterized by the occurrence of an initial erythematosquamous plaque followed by the appearance of disseminated similar but smaller lesions one or two weeks later. Several patients develop systemic symptoms such as nausea, anorexia, malaise, headache, fever, arthralgia, and lymphadenopathy that may precede or accompany the eruption; the latter follows the cleavage lines of the trunk creating the configuration of a Christmas tree and spontaneously resolves within 4 to 8 weeks...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28122875/rapid-identification-of-clinically-relevant-members-of-the-genus-exophiala-by-maldi-tof-mass-spectrometry-and-description-of-two-novel-species-exophiala-campbellii-and-exophiala-lavatrina
#15
Andrew M Borman, Mark Fraser, Adrien Szekely, Daniel E Larcombe, Elizabeth M Johnson
Exophiala is a ubiquitous pleomorphic genus comprising at least forty species, many of which have been associated with superficial, visceral or systemic infections in humans, other mammals or cold-blooded animals. In this study we investigated the potential of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF MS) for the identification of Exophiala species. A total of 89 isolates (including 50 human and 4 animal clinical isolates) stored in the National Collection of Pathogenic Fungi were identified by PCR amplification and sequencing of the internal transcribed spacer region 1...
January 25, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28116600/transungual-gel-of-terbinafine-hydrochloride-for-the-management-of-onychomycosis-formulation-optimization-and-evaluation
#16
Purva Thatai, Bharti Sapra
The present study was aimed to optimize, develop, and evaluate microemulsion and microemulsion-based gel as a vehicle for transungual drug delivery of terbinafine hydrochloride for the treatment of onychomycosis. D-optimal mixture experimental design was adopted to optimize the composition of microemulsion having amount of oil (X 1), Smix (mixture of surfactant and cosurfactant; X 2), and water (X 3) as the independent variables. The formulations were assessed for permeation (micrograms per square centimeter per hour; Y 1), particle size (nanometer; Y 2), and solubility of the drug in the formulation (milligrams per milliliter; Y 3)...
January 23, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28115356/evolution-of-the-sterol-biosynthetic-pathway-of-pythium-insidiosum-and-related-oomycetes-contributes-to-antifungal-drug-resistance
#17
Tassanee Lerksuthirat, Areeporn Sangcakul, Tassanee Lohnoo, Wanta Yingyong, Thidarat Rujirawat, Theerapong Krajaejun
Pythiosis is a life-threatening infectious disease, caused by the oomycete Pythium insidiosum Direct exposure to P. insidiosum zoospores can initiate infections of the eye, limb, gastrointestinal tract, or skin/subcutaneous tissue. Treatments for pythiosis have mostly relied on surgery. Antifungal drugs are generally ineffective against P. insidiosum However, one patient with an invasive P. insidiosum infection recovered completely, following treatment with terbinafine and itraconazole. Additionally, the drug-target sterol biosynthetic enzymes have been identified in the oomycete Aphanomyces euteiches It remains an open question whether P...
January 23, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28099612/tinea-faciei-on-the-right-eyebrow-caused-by-trichophyton-interdigitale
#18
Kai Wen Zhuang, Ya Ling Dai, Yu Ping Ran, Jebina Lama, Yi Ming Fan
Tinea faciei is a relatively uncommon dermatophyte infection entailing atypical clinical symptoms, usually misdiagnosed and treated with corticosteroids. The authors describe a case of tinea faciei on the right eyebrow caused by Trichophyton interdigitale. The patient was an 18-year-old girl, who had an inflammatory plaque with a scaly, pustular surface on the right eyebrow and upper eyelid, which had persisted for over 1 month. She was once misdiagnosed as having eczema and was treated using corticosteroid cream...
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28097731/efficacy-and-tolerability-of-amorolfine-5-nail-lacquer-in-combination-with-systemic-antifungal-agents-for-onychomycosis-a-meta-analysis-and-systematic-review
#19
REVIEW
Xiaowei Feng, Xincai Xiong, Yuping Ran
The efficacy and safety of amorolfine 5% nail lacquer in combination with systemic antifungal agents in the treatment of the onychomycosis were evaluated. According to our meta-analysis, combination treatment of amorolfine 5% nail lacquer and systemic antifungals can result in higher percentage of complete clearance of onychomycosis. It showed that the experimental combination group was more effective than monotherapy of the systemic antifungals [OR (odds ratio) = 1.97, 95%CI (95% confidence interval) = 1...
January 18, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28066103/efficacy-and-tolerability-of-topical-sertaconazole-versus-topical-terbinafine-in-localized-dermatophytosis-a-randomized-observer-blind-parallel-group-study
#20
Dattatreyo Chatterjee, Sudip Kumar Ghosh, Sukanta Sen, Saswati Sarkar, Avijit Hazra, Radharaman De
OBJECTIVE: Epidermal dermatophyte infections most commonly manifest as tinea corporis or tinea cruris. Topical azole antifungals are commonly used in their treatment but literature suggests that most require twice-daily application and provide lower cure rates than the allylamine antifungal terbinafine. We conducted a head-to-head comparison of the effectiveness of the once-daily topical azole, sertaconazole, with terbinafine in these infections. MATERIALS AND METHODS: We conducted a randomized, observer-blind, parallel group study (Clinical Trial Registry India [CTRI]/2014/09/005029) with adult patients of either sex presenting with localized lesions...
November 2016: Indian Journal of Pharmacology
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