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https://www.readbyqxmd.com/read/29145153/the-pro-apoptosis-effect-of-sinomenine-in-renal-carcinoma-via-inducing-autophagy-through-inactivating-pi3k-akt-mtor-pathway
#1
Fei Deng, Yue-Xian Ma, Liang Liang, Ping Zhang, Jing Feng
Renal cell carcinoma (RCC) is a heterogeneous histological disease and the most common kidney cancer. The mortality rate of RCC remains high despite the improved treatment. Sinomenine is an isoquinoline extracted from Chinese medicinal plant Sinomenium acutum, famous for its ability to suppress several cancer cell types. Our research aimed to explore the anti-cancer potential of sinomenine in RCC. Results showed that sinomenine reduced the viability by reducing sphere-forming ability and enhancing pro-apoptosis effect in ACHN cells in a dose dependent manner...
November 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29143408/automated-synthesis-of-pet-radiotracers-by-copper-mediated-18-f-fluorination-of-organoborons-importance-of-the-order-of-addition-and-competing-protodeborylation
#2
Andrew V Mossine, Allen F Brooks, Vadim Bernard-Gauthier, Justin J Bailey, Naoko Ichiishi, Ralf Schirrmacher, Melanie S Sanford, Peter J H Scott
In this paper we describe the use of Cu-mediated [(18) F]fluorodeboronation for the automated production of PET radiotracers suitable for clinical use. Two recurrent issues with the method, low radiochemical conversion (RCC) on automation and protoarene byproduct purification issues, have been successfully addressed. The new method was utilized to produce sterile injectable doses of [(18) F]-(±)-IPMICF17, a PET radiotracer for tropomyosin receptor kinase B/C, using an automated synthesis module. Product was isolated in 1...
November 16, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29141556/selecting-patients-with-small-renal-masses-for-active-surveillance
#3
Michael H Johnson, Mohamad E Allaf, Phillip M Pierorazio
The incidentally discovered, clinically-localized, small renal mass (clinical stage T1aN0M0, ≤4cm) is the most commonly diagnosed entity in renal cell carcinoma (RCC) - now accounting for at least 40% of newly diagnosed renal tumors. Given the above argument, active surveillance (AS) has emerged as a viable management strategy for SRM. This review will examine and discuss the existing literature regarding selection criteria for AS. AS of clinical T1a renal masses is emerging as a safe and effective management strategy in selected patients, yet appropriate patient selection and counseling remains an area of great interest...
November 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29138826/mir%C3%A2-660%C3%A2-5p-is-associated-with-cell-migration-invasion-proliferation-and-apoptosis-in-renal-cell-carcinoma
#4
Tao He, Peijie Chen, Lu Jin, Jia Hu, Yifan Li, Liang Zhou, Shangqi Yang, Xiangming Mao, Yaoting Gui, Yun Chen, Yongqing Lai
Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system with poor prognosis. microRNAs (miRNAs) are a class of small, non‑coding RNA molecules that serve important roles in biological and pathological processes in several types of human tumors. miRNA (miR)‑660‑5p is dysregulated in many human cancers; however, its role in renal cell carcinoma is currently unclear. In the present study, reverse transcription‑quantitative polymerase chain reaction was performed to examine the expression levels of miR‑660‑5p in RCC tissues and paired normal adjacent tissues (NATs)...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29137443/the-clinical-use-of-the-platelet-to-lymphocyte-ratio-and-lymphocyte-to-monocyte-ratio-as-prognostic-factors-in-renal-cell-carcinoma-a-systematic-review-and-meta-analysis
#5
Xuemin Wang, Shiqiang Su, Yuanshan Guo
Conflicting evidence exists regarding the effect of platelet to lymphocyte ratio (PLR) and lymphocyte to monocyte ratio (LMR) on the prognosis of renal cell carcinoma (RCC) patients. Here we quantify the prognostic impact of these biomarkers and assess their consistency in RCC. Eligible studies were retrieved from the PubMed, Embase and Web of Science databases. Pooled hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated. Sixteen studies containing 6,223 patients met criteria for inclusion...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137334/the-coffee-diterpene-kahweol-enhances-sensitivity-to-sorafenib-in-human-renal-carcinoma-caki-cells-through-down-regulation-of-mcl-1-and-c-flip-expression
#6
Kyoung-Jin Min, Hee Jung Um, Jee In Kim, Taeg Kyu Kwon
Sorafenib is approved for the treatment of hepatocellular carcinoma (HCC) and advanced renal cell carcinoma (RCC). However, low tumor response and side effects have been widely reported. Therefore, to improve the efficacy of sorafenib, we investigated whether combined treatment with sorafenib and kahweol, the coffee-specific diterpene, has a synergistic effect on apoptotic cell death. Combined treatment with sorafenib and kahweol markedly induced caspase-mediated apoptosis in renal carcinoma Caki cells. Combined treatment with sorafenib and kahweol induced down-regulation of Mcl-1 and c-FLIP expression...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137245/associations-between-polymorphisms-in-the-il-4-gene-and-renal-cell-carcinoma-in-chinese-han-population
#7
Hao Rong, Xue He, Li Wang, Yongjun He, Longli Kang, Tianbo Jin
Renal cell carcinoma (RCC) is considered to be a kind of cytokine reactive tumor. The research has been suggested that the host immune system can regulate the clinical course of RCC. Therefore, cytokine gene polymorphisms in RCC patients were analyzed was necessary. Our study is purpose to analyzing the interleukin-4(IL-4) polymorphisms associated with RCC risk from Han Chinese population. IL-4 genetic polymorphisms were genotyped using Massarray technology from a total of 291RCC and 463 controls. Unconditional logistic regression analysis was performed to analyze their relationship with risk of RCC...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135120/immunohistochemical-study-of-cyclin-a-and-p16-expression-in-patients-with-renal-cell-carcinoma
#8
Dragana Latic, Sanja Radojevic-Skodric, Srdjan Nikolic, Mirjana Prvanovic, Miodrag Lazic, Zoran Dzamic, Ljiljana Bogdanovic, Milena Radunovic, Marina Vukovic
PURPOSE: Renal cell carcinoma (RCC) is the most common malignant kidney tumor in adults. Dysregulation of the cell cycle can lead to cancer development. In this study, the mitosis-associated cyclin A and p16, a negative controller, were investigated as potential key points in the RCC development. METHODS: This retrospective study included 74 patients with RCC. The expression of cyclin A and p16 and their correlation to histopathological parameters (TNM stage, histological subtype, nuclear grade, tumor size), gender, age, and clinical outcome were studied and analyzed...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29134348/machine-learning-based-quantitative-texture-analysis-of-ct-images-of-small-renal-masses-differentiation-of-angiomyolipoma-without-visible-fat-from-renal-cell-carcinoma
#9
Zhichao Feng, Pengfei Rong, Peng Cao, Qingyu Zhou, Wenwei Zhu, Zhimin Yan, Qianyun Liu, Wei Wang
OBJECTIVE: To evaluate the diagnostic performance of machine-learning based quantitative texture analysis of CT images to differentiate small (≤ 4 cm) angiomyolipoma without visible fat (AMLwvf) from renal cell carcinoma (RCC). METHODS: This single-institutional retrospective study included 58 patients with pathologically proven small renal mass (17 in AMLwvf and 41 in RCC groups). Texture features were extracted from the largest possible tumorous regions of interest (ROIs) by manual segmentation in preoperative three-phase CT images...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29133143/pathologic-and-clinical-characteristics-of-early-onset-renal-cell-carcinoma
#10
Tyler Clemmensen, Andres Matoso, Tiffany Graham, Win Shun Lai, Soroush Rais-Bahrami, Jennifer Gordetsky
The majority of RCCs occur within the 7th decade of life, uncommonly arising in adults ≤46years. We reviewed the clinicopathologic features of early-onset renal cell carcinoma (RCC) and evaluated the role of immunohistochemistry (IHC) in potentially identifying diagnoses of newly recognized RCC subtypes that may have been previously misclassified. A retrospective review was performed from 2011-2016 for cases of RCC. Early-onset RCC was defined as ≤46years of age. Clinicopathologic findings and hematoxylin and eosin (H&E) slides were reviewed on early-onset RCC patients...
November 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/29132713/perioperative-morbidity-of-lymph-node-dissection-for-renal-cell-carcinoma-a-propensity-score-based-analysis
#11
Boris Gershman, Daniel M Moreira, R Houston Thompson, Stephen A Boorjian, Christine M Lohse, Brian A Costello, John C Cheville, Bradley C Leibovich
BACKGROUND: There are little data regarding the morbidity of lymph node dissection (LND) for renal cell carcinoma (RCC) to assess its risk-benefit ratio. OBJECTIVE: To evaluate the association of LND with 30-d complications among patients undergoing radical nephrectomy (RN) for RCC. DESIGN, SETTING, AND PARTICIPANTS: A total of 2066 patients underwent RN for M0 or M1 RCC between 1990 and 2010, of whom 774 (37%) underwent LND. INTERVENTION: RN with or without LND...
November 10, 2017: European Urology
https://www.readbyqxmd.com/read/29131770/differentiation-of-solid-renal-tumors-with-multiparametric-mr-imaging
#12
Camila Lopes Vendrami, Carolina Parada Villavicencio, Todd J DeJulio, Argha Chatterjee, David D Casalino, Jeanne M Horowitz, Daniel T Oberlin, Guang-Yu Yang, Paul Nikolaidis, Frank H Miller
Characterization of renal tumors is critical to determine the best therapeutic approach and improve overall patient survival. Because of increased use of high-resolution cross-sectional imaging in clinical practice, renal masses are being discovered with increased frequency. As a result, accurate imaging characterization of these lesions is more important than ever. However, because of the wide array of imaging features encountered as well as overlapping characteristics, identifying reliable imaging criteria for differentiating malignant from benign renal masses remains a challenge...
November 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29131259/microrna-21-functions-as-an-oncogene-and-promotes-cell-proliferation-and-invasion-via-timp3-in-renal-cancer
#13
J Chen, Y Gu, W Shen
OBJECTIVE: Renal cell carcinoma (RCC) displays an increasing incidence and mortality rate worldwide in recent years. More and more evidence identified microRNAs function as positive or negative regulatory factors in many cancers, but the role of miR-21 in RCC remains unclear. PATIENTS AND METHODS: Relative expression levels of miR-21 in human RCC tissue samples and RCC-derived cell lines were measured using quantitative real-time Polymerase Chain Reaction (PCR)...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29131154/impact-of-hla-g-polymorphism-on-the-outcome-of-allogeneic-hematopoietic-stem-cell-transplantation-for-metastatic-renal-cell-carcinoma
#14
R Crocchiolo, O Ringden, J-O Bay, D Blaise, B Omasic, B Mazzi, C Picard, S Trinca, L Barkholt, J Peccatori, S Gregori, G Amodio, K Fleischhauer, F Ciceri, M Bregni
Renal cell carcinoma (RCC) is particularly sensitive to immune intervention. HLA-G, a non-classical HLA class I molecule with immunomodulatory properties, has been studied with regard to outcome after hematopoietic stem cell transplantation (HSCT), in particular the 14 bp insertion/deletion polymorphism in the 3' untranslated region. Here we analyzed n=56 patients affected by metastatic RCC who received an allogeneic HSCT between 1998 and 2006 in Milano, Marseille, Clermont-Ferrand and Stockholm. The 14 bp polymorphism was analyzed in correlation with overall survival (OS), PFS, acute and chronic GvHD...
November 13, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29130345/mir-199a-targeting-rock1-to-affect-kidney-cell-proliferation-invasion-and-apoptosis
#15
Zhigang Qin, Xin Wei, Ning Jin, Yao Wang, Rui Zhao, Yangqing Hu, Weijian Yan, Junke Li, Qiaoling Zhou
Renal cell carcinoma (RCC) is one of the three most common cancers of urinary tract cancer, accounting for 2-3% of all systemic cancers. Recent studies have found that miR-199a is lowly expressed in RCC, may act as a tumour suppressor gene to induce the occurrence of kidney cancer. In the present study, we investigated the role of miR-199a in the progression and metastasis of RCC. The results showed that miR-199a significantly downregulated in RCC and cell lines. Overexpression of miR-199a in RCC cell lines significantly inhibited cell proliferation, migration and invasion...
November 13, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29130016/incidental-eosinophilic-chromophobe-renal-cell-carcinoma-in-renal-allograft
#16
Abdullah Alharbi, Maram S Al Turki, Noura Aloudah, Khaled O Alsaad
The incidence of renal cell carcinoma (RCC) in renal allograft in transplant recipients is 0.22-0.25%. De novo clear cell, papillary, and chromophobe RCCs and RCCs with sarcomatoid differentiation originating in renal allograft have been reported. Routine surveillance for graft tumours is not routinely practiced and these tumours are commonly asymptomatic and incidentally discovered. We describe a case of incidental, eosinophilic chromophobe RCC in a 31-year-old, long-term renal transplant male recipient, who presented with acute gastroenteritis 11 years after transplantation...
2017: Case Reports in Transplantation
https://www.readbyqxmd.com/read/29129353/impact-of-lymph-node-dissection-at-the-time-of-radical-nephrectomy-with-tumor-thrombectomy-on-oncological-outcomes-results-from-the-international-renal-cell-carcinoma-venous-thrombus-consortium-ircc-vtc
#17
Derya Tilki, Thenappan Chandrasekar, Umberto Capitanio, Gaetano Ciancio, Siamak Daneshmand, Paolo Gontero, Javier Gonzalez, Axel Haferkamp, Markus Hohenfellner, William C Huang, Estefania Linares Espinós, Adam Lorentz, Juan I Martinez-Salamanca, Viraj A Master, James M McKiernan, Francesco Montorsi, Giacomo Novara, Sascha Pahernik, Juan Palou, Raj S Pruthi, Oscar Rodriguez-Faba, Paul Russo, Douglas S Scherr, Shahrokh F Shariat, Martin Spahn, Carlo Terrone, Cesar Vera-Donoso, Richard Zigeuner, John A Libertino, Christopher P Evans
OBJECTIVES: To study the effect of lymph node dissection (LND) at the time of nephrectomy and tumor thrombectomy on oncological outcomes in patients with renal cell carcinoma (RCC) and tumor thrombus. PATIENTS AND METHODS: The records of 1,978 patients with RCC and tumor thrombus who underwent radical nephrectomy and tumor thrombectomy from 1985 to 2014 at 24 centers were analyzed. None of the patients had distant metastases. Extent and pathologic results of LND were compared with respect to cancer-specific survival (CSS)...
November 9, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29128599/cutaneous-metastasis-of-renal-cell-carcinoma-masquerading-as-an-infected-sebaceous-cyst
#18
Ranil Johann Boaz, Tanush Vig, Amit Jiwan Tirkey, Nirmal Thampi John, Ramani Manoj Kumar, Nitin Kekre
Renal cell carcinoma (RCC) is the third most common genitourinary malignancy with an estimated 1/3(rd) of cases with metastatic disease at the time of diagnosis. Though rare, cutaneous metastasis from RCC is more frequent than any other genitourinary malignancy. Metastasis of RCC to skin carries poor prognosis as coexistent visceral spread is the norm. A 38-year-old man presented one year after radical nephrectomy for clear cell carcinoma of the left kidney with a submental lesion that proved to be metastatic...
November 8, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29128576/evaluation-of-tumor-pseudocapsule-status-and-its-prognostic-significance-in-renal-cell-carcinoma
#19
Wei Xi, Jiajun Wang, Li Liu, Ying Xiong, Yang Qu, Zhiyuan Lin, Xiang Chen, Zewei Wang, Jiejie Xu, Jianming Guo
PURPOSE: To determine whether tumor pseudocapsule status- extent of invasion by cancer and lack of pseudocapsule- is of prognostic value in renal cell carcinoma (RCC). MATERIALS AND METHODS: We retrospectively reviewed 1577 RCC patients of different stages who underwent nephrectomy at out institution, and 1307 (82.9%) were eligible for analyses. Presented PS was classified into completely intact (Grade 0), mere involved (Grade 1) and penetrated (Grade 2) categories...
November 8, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29125336/a-useful-method-for-assessing-differences-of-compensatory-hypertrophy-in-the-contralateral-kidney-before-and-after-radical-nephrectomy-in-patients-with-renal-cell-carcinoma-ellipsoid-formula-on-computed-tomography
#20
Bong Hee Park, Kang Jun Cho, Jung Im Kim, Sang Rak Bae, Yong Seok Lee, Sung Hak Kang, Joon Chul Kim, Chang Hee Han
OBJECTIVE: To investigate the usefulness of the ellipsoid formula for assessing compensatory hypertrophy of the contralateral kidney on preoperative and postoperative CT in renal cell carcinoma(RCC) patients. METHODS: We retrospectively identified 389 patients who had radical nephrectomy for RCC between 2011 and 2015. Contrast-enhanced CT was performed within three months preoperative and at 1 year postoperative. The kidney volumes were calculated from CT using the ellipsoid formula...
November 10, 2017: British Journal of Radiology
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