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https://www.readbyqxmd.com/read/28211356/correction-synergistic-activity-of-parp-inhibition-by-talazoparib-bmn-673-with-temozolomide-in-pediatric-cancer-models-in-the-pediatric-preclinical-testing-program
#1
(no author information available yet)
No abstract text is available yet for this article.
February 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28160078/proteomic-analysis-of-bmn-cell-lipid-rafts-reveals-roles-in-bombyx-mori-nucleopolyhedrovirus-infection
#2
Xiaolong Hu, Min Zhu, Zi Liang, Dhiraj Kumar, Fei Chen, Liyuan Zhu, Sulan Kuang, Renyu Xue, Guangli Cao, Chengliang Gong
The mechanism of how Bombyx mori nucleopolyhedrovirus (BmNPV) enters cells is unknown. The primary components of membrane lipid rafts are proteins and cholesterol, and membrane lipid rafts are thought to be an active region for host-viral interactions. However, whether they contribute to the entry of BmNPV into silkworm cells remains unclear. In this study, we explored the membrane protein components of lipid rafts from BmN cells with mass spectrometry (MS). Proteins and cholesterol were investigated after establishing infection with BmNPV in BmN cells...
February 3, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28065477/quantitative-analysis-of-the-yield-of-avian-h7-influenza-virus-haemagglutinin-protein-produced-in-silkworm-pupae-with-the-use-of-the-codon-optimized-dna-a-possible-oral-vaccine
#3
Kuniaki Nerome, Sayaka Matsuda, Kenichi Maegawa, Shigeo Sugita, Kazumichi Kuroda, Kazunori Kawasaki, Reiko Nerome
In this study, we aimed to quantitatively compare the increased production of three H7 influenza virus-like particle (VLP) haemagglutinin (HA) with the use of a codon-optimized single HA gene in silkworm pupae. Recombinant baculovirus (Korea H7-BmNPV) could produce 0.40 million HA units per pupa, corresponding to 1832μg protein. The yield of the HA produced in larva was estimated to be approximately 0.31 million HA units per larva, and there were no significant differences between the three HA proteins. We could establish efficient recovery system of HA production in larvae and pupae with the use of three cycles sonication methods...
February 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28032930/20-hydroxyecdysone-enhances-the-expression-of-the-chitinase-5-via-broad-complex-zinc-finger-4-during-metamorphosis-in-silkworm-bombyx-mori
#4
X Zhang, S Zheng
Insect chitinases are hydrolytic enzymes required for the degradation of chitin. They are essential for insect moulting and metamorphosis. In this study, the regulation mechanism of a chitinase gene, Bombyx mori chitinase 5 (BmCHT5), was studied. Quantitative reverse transcription PCR (qRT-PCR) analysis showed that BmCHT5 was up-regulated during the larval-larval and larval-pupa transitions and notably induced by 20-hydroxyecdysone (20E). Analysis of the BmCHT5 promoter revealed the presence of one Bombyx mori Broad-Complex Zinc-Finger Isoform 4 (BR-C Z4), two BR-C Z2 and two ecdysone-induced protein 74A (E74A) cis-regulatory elements (CREs) that are related to 20E...
December 29, 2016: Insect Molecular Biology
https://www.readbyqxmd.com/read/28002809/preclinical-evaluation-of-the-parp-inhibitor-bmn-673-for-the-treatment-of-ovarian-clear-cell-cancer
#5
Paul M Wilkerson, Konstantin J Dedes, Eleftherios Pierre Samartzis, Ioannis Dedes, Maryou B Lambros, Rachael Natrajan, Arnaud Gauthier, Salvatore Piscuoglio, Chantal Töpfer, Vesna Vukovic, Frances Daley, Britta Weigelt, Jorge S Reis-Filho
PURPOSE: To determine if models of ovarian clear cell carcinomas (OCCCs) harbouring defects in homologous recombination (HR) DNA repair of double strand breaks (DSBs) are sensitive to cisplatin and/or PARP inhibition. EXPERIMENTAL DESIGN: The HR status of 12 OCCC cell lines was determined using RAD51/γH2AX foci formation assays. Sensitivity to cisplatin and the PARP inhibitor BMN-673 was correlated with HR status. BRCA1, BRCA2, MRE11 and PTEN loss of expression was investigated as a potential determinant of BMN-673 sensitivity...
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/27965095/bmnhr96-participate-bv-entry-of-bmn-swu1-cells-via-affecting-the-cellular-cholesterol-level
#6
Xiao-Long Dong, Tai-Hang Liu, Wei Wang, Cai-Xia Pan, Guo-Yu Du, Yun-Fei Wu, Min-Hui Pan, Cheng Lu
B.mori nucleopolyhedrovirus (BmNPV), which produces BV and ODV two virion phenotypes in its life cycle, caused the amount of economic loss in sericulture. But the mechanism of its infection was still unclear. In this study we characterized B.mori nuclear hormone receptor 96 (BmNHR96) as a NHR96 family member, which was localized in the nucleus. We also found BmNHR96 over-expression could enhance the entry of BV as well as cellular cholesterol level. Furthermore, we validated that BmNHR96 increased membrane fusion mediated by GP64, which could probably promote BV-infection...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27941282/donor-cell-leukemia-with-bone-marrow-necrosis
#7
Shuntaro Ikegawa, Yuho Najima, Naoki Sano, Shin-Ichiro Horiguchi, Satoshi Kaito, Shuhei Kurosawa, Masahiro Sakaguchi, Kaito Harada, Yutaro Hino, Keita Yamamoto, Yasushi Senoo, Daisuke Watanabe, Kosuke Yoshioka, Kyoko Watakabe, Aiko Igarashi, Noriko Doki, Takeshi Kobayashi, Kazuhiko Kakihana, Hisashi Sakamaki, Tsunekazu Hishima, Kazuteru Ohashi
A 60-year-old man with myelodysplastic syndrome underwent allogeneic transplantation of female umbilical cord blood in 2010 and sustained a complete remission. He experienced severe pain in his left hip joint and was admitted to the orthopedic surgery division of our institution in February 2015. After admission, he was suspected to have hemophagocytic syndrome (HPS) and was thus transferred to the hematology division. Bone marrow aspiration revealed hyper-cellular marrow filled with abnormal collapsed cells, consistent with bone marrow necrosis (BMN)...
2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/27856936/reveglucosidase-alfa-bmn-701-an-igf-2-tagged-rhacid-%C3%AE-glucosidase-improves-respiratory-functional-parameters-in-a-murine-model-of-pompe-disease
#8
Jeff Peng, Jill Dalton, Mark Butt, Kristin Tracy, Derek Kennedy, Peter Haroldsen, Rhea Cahayag, Stephen Zoog, Charles A O'Neill, Laurie Tsuruda
Pompe disease is a rare neuromuscular disorder caused by an acid α-glucosidase (GAA) deficiency resulting in glycogen accumulation in muscle, leading to myopathy and respiratory weakness. Reveglucosidase alfa (BMN 701), is an insulin-like growth factor 2 (IGF2) tagged rhGAA that enhances rhGAA cellular uptake via a glycosylation independent IGF2-binding region of the cation-independent mannose-6-phosphate receptor (CI-MPR). These studies evaluated the effects of reveglucosidase alfa treatment on glycogen clearance in muscle relative to rhGAA as well as changes in respiratory function and glycogen clearance in respiratory related tissue in a Pompe mouse model (GAA(tm1Rabn))...
November 16, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27855521/elosulfase-alfa-bmn-110-for-the-treatment-of-mucopolysaccharidosis-iva-morquio-a-syndrome
#9
Christian J Hendriksz
Morquio A syndrome is a rare, autosomal recessive, lysosomal storage disorder caused by a deficiency in the enzyme N-acetylgalactosamine-6-sulfatase (GALNS). In 2014, the use of recombinant human GALNS, elosulfase alfa, was approved in the European Union, Canada, the United States, Australia, and Brazil for the treatment of Morquio A syndrome. Elosulfase alfa is administered intravenously once-weekly at a dose of 2.0 mg/kg. Areas covered: This is a review of the efficacy, safety and tolerability, pharmacokinetics and pharmacodynamics, and other outcomes of elosulfase alfa treatment of patients with Morquio A...
December 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27649890/ricin-b-lectin-enhances-microsporidia-nosema-bombycis-infection-in-bmn-cells-from-silkworm-bombyx-mori
#10
Han Liu, Mingqian Li, Shunfeng Cai, Xinyi He, Yongqi Shao, Xingmeng Lu
Nosema bombycis is an obligate intracellular parasitic fungus that utilizes a distinctive mechanism to infect Bombyx mori Spore germination can be used for host cell invasion; however, the detailed mechanism remains to be elucidated. The ricin-B-lectin (RBL) gene is significantly differentially regulated after N. bombycis spore germination, and NbRBL might play roles in spore germination and infection. In this study, the biological function of NbRBL was examined. Protein sequence analysis showed that NbRBL is a secreted protein that attaches to carbohydrates...
November 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/27640438/functional-characterization-of-bombyx-mori-nucleopolyhedrovirus-mutant-lacking-late-expression-factor-9
#11
Y Zhang, Y Shi, H Yu, J Li, Y Quan, T Shu, Z Nie, Y Zhang, W Yu
Baculoviridae is a family of invertebrate viruses with large double-stranded DNA genomes. Proteins encoded by some late expression factor (lef ) genes are involved in the regulation of viral gene expression. Lef-9 is one of four transcription-specific Lefs, which are components of the virus-encoded RNA polymerase, and can initiate and transcribe late and very late genes. As a multifunctional protein encoded by the Bombyx mori nucleopolyhedrovirus (BmNPV), Lef-9 may be involved in the regulation of viral propagation...
2016: Acta Virologica
https://www.readbyqxmd.com/read/27630941/buccal-micronuclei-assay-as-a-tool-for-biomonitoring-dna-damage-in-oral-lichen-planus
#12
S Vidyalakshmi, R Madhavan Nirmal, V Veeravarmal, A Santhadevy, R Aravindhan, Sumathy
INTRODUCTION: The malignant transformation rate of Oral Lichen Planus (OLP) is between 0% and 5.8%. Oral lesions of lichen planus clinically presents itself multifocally, simulating the process of field cancerization in high risk malignancies. The Buccal MicroNucleus Cytome Assay (BMN Assay) provides a platform to identify the high risk individuals by evaluating the markers of nuclear damage at an earliest micro invasive phase. AIM: To evaluate DNA damage in exfoliated buccal mucosal cells in individuals with oral lichen planus lesions and thereby to delineate the high risk group...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27558456/bmdredd-regulates-the-apoptosis-coordinating-with-bmdaxx-bmcide-b-bmfadd-and-bmcreb-in-bmn-cells
#13
Rui-Ting Chen, Peng Jiao, Yan Lu, Hu-Hu Xin, Deng-Pan Zhang, Mei-Xian Wang, Shuang Liang, Yun-Gen Miao
The apoptosis mechanisms in mammals were investigated relatively clearly. However, little is known about how apoptosis is achieved at a molecular level in silkworm cells. We cloned a caspase homologous gene named BmDredd (where Bm is Bombyx mori and Dredd is death-related ced-3/Nedd2-like caspase) in BmN cells from the ovary of Bm and analyzed its biological information. We constructed the N-terminal, C-terminal, and overexpression vector of BmDredd, respectively. Our results showed that the transcriptional expression level of BmDredd was increased in the apoptotic BmN cells...
November 2016: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/27521907/insecticide-cytotoxicology-in-china-current-status-and-challenges
#14
REVIEW
Guohua Zhong, Gaofeng Cui, Xin Yi, Ranran Sun, Jingjing Zhang
The insecticide cytotoxicology, as a new branch of toxicology, has rapidly developed in China. During the past twenty years, thousands of investigations have sprung up to evaluate the damages and clarify the mechanisms of insecticidal chemical substances to insect cells in vivo or in vitro. The mechanisms of necrosis, apoptosis or autophagy induced by synthetic or biogenic pesticides and virus infections have been systematically illuminated in many important models, including S2, BmN, SL-1, Sf21 and Sf9 cell lines...
September 2016: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/27447797/novel-infection-system-of-recombinant-bmbdv-dna-into-bmn-cells-of-silkworm-bombyx-mori
#15
Rui Guo, Guangli Cao, Yuexiong Zhu, Dhiraj Kumar, Renyu Xue, Yahong Lu, Xiaolong Hu, Chengliang Gong
Bombyx mori bidensovirus (BmBDV) was previously termed as Bombyx mori densovirus type 2 and later it was reclassified in the new genus bidensovirus of the new family Bidnaviridae. The genome of BmBDV Zhenjiang isolate (BmBDV-Z) consists of two non-homologous single-stranded linear DNA molecules VD1 and VD2 which are encapsidated into separate virion. To investigate the infectivity of BmBDV DNA, recombinant plasmids pGEM-VD1 inserted with VD1 genome were transfected into the BmN cells of silkworm. Structural proteins of BmBDV were detected with Western blot and immunofluorescence assay, which indicates pGEM-VD1 replicated in the transfected BmN cells and viral proteins were also expressed...
October 2016: Current Microbiology
https://www.readbyqxmd.com/read/27433418/extensive-bone-marrow-necrosis-and-osteolytic-lesions-in-a-case-of-acute-myeloid-leukemia-transformed-from-polycythemia-vera
#16
Isaac Chambers, Phu Truong, K James Kallail, William Palko
Acute myeloid leukemia (AML) is the most common leukemia in adults. In rare cases, bone marrow necrosis (BMN) and osteolytic lesions are presenting features of AML. The following case describes a patient with known polycythemia vera (PV) that presented with signs of multiple myeloma, including hypercalcemia, anemia, and lytic lesions of the thoracic spine and skull. Laboratory workup was not indicative of myeloma. A bone marrow biopsy was performed, which revealed extensive BMN and initial pathology was consistent with metastatic carcinoma...
2016: Curēus
https://www.readbyqxmd.com/read/27432352/thymosin-from-bombyx-mori-is-down-regulated-in-expression-by-bmnpv-exhibiting-antiviral-activity
#17
Chen Zhang, Yongdi Wang, Qiang Fang, Minlin Xu, Mengyuan Lv, Jinxu Liao, Si Li, Zuoming Nie, Wenping Zhang
Thymosins have been highly conserved during evolution. These hormones exist in many animal species and play an essential role in many biological events. However, little is known regarding the physiological function of silkworm Bombyx mori thymosin (BmTHY). In this study, we investigated the expression pattern of BmTHY in a Bombyx mori larval ovarian cell line (BmN) challenged with Bombyx mori nuclear polyhydrosis virus (BmNPV) and the antiviral effect of recombinant BmTHY (rBmTHY) for Bombyx mori against BmNPV...
2016: Journal of Insect Science
https://www.readbyqxmd.com/read/27414795/a-dna-binding-protein-is-required-for-viral-replication-and-transcription-in-bombyx-mori-nucleopolyhedrovirus
#18
Cui Zhao, Chen Zhang, Bin Chen, Yanghui Shi, Yanping Quan, Zuoming Nie, Yaozhou Zhang, Wei Yu
A DNA-binding protein (DBP) [GenBank accession number: M63416] of Bombyx mori nuclear polyhedrosis virus (BmNPV) has been reported to be a regulatory factor in BmNPV, but its detailed functions remain unknown. In order to study the regulatory mechanism of DBP on viral proliferation, genome replication, and gene transcription, a BmNPV dbp gene knockout virus dbp-ko-Bacmid was generated by the means of Red recombination system. In addition, dbp-repaired virus dbp-re-Bacmid was constructed by the means of the Bac to Bac system...
2016: PloS One
https://www.readbyqxmd.com/read/27402326/expression-and-effects-of-mutant-bombyx-mori-acetylcholinestrase1-in-bmn-cells
#19
Bin-Bin Wang, Yi Xie, Fan-Chi Li, Min Ni, Kai-Zun Xu, Jiang-Hai Tian, Jing-Sheng Hu, Bin Xue, Wei-De Shen, Bing Li
The main mechanism of toxicity of organophosphate (OP) and carbamate (CB) insecticides is their irreversible binding and inhibition of acetylcholinestrase (AChE), encoded by ace1 (acetylcholinestrase gene 1), leading to eventual death of insects. Mutations in AChE may significantly reduce insects susceptibility to these pesticides. Bombyx mori is an important beneficial insect, and no OP- or CB-resistant strains have been generated. In this study, wild-type ace1 (wace1) and mutant ace1 (mace1) were introduced into BmN cells, confirmed by screening and identification...
October 2016: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/27391602/cloning-and-rescue-of-the-genome-of-bombyx-mori-bidensovirus-and-characterization-of-a-recombinant-virus
#20
Panpan Zhang, Di Miao, Yahui Zhang, Meizi Wang, Zhaoyang Hu, Peng Lü, Qin Yao
BACKGROUND: Bombyx mori bidensovirus (BmBDV), which belongs to the Bidnaviridae family established by the International Committee on Taxonomy of Viruses in 2011, was the first bidensovirus identified in insects. The structure of BmBDV is similar to that of parvoviruses, while its replication is similar to that of adenoviruses. Although BmBDV has the potential to be used as a tool in biological pest control and as an expression vector, virus rescue has been a bottleneck in the application of this virus...
2016: Virology Journal
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