keyword
MENU ▼
Read by QxMD icon Read
search

ionizing radiation exposure

keyword
https://www.readbyqxmd.com/read/28936535/8-oxo-7-8-dihydro-2-deoxyguanosine-and-abasic-site-tandem-lesions-are-oxidation-prone-yielding-hydantoin-products-that-strongly-destabilize-duplex-dna
#1
Aaron M Fleming, Cynthia J Burrows
In DNA, 2'-deoxyguanosine (dG) is susceptible to oxidative modification by reactive oxygen species (ROS) yielding many products, one of which is 8-oxo-7,8-dihydro-2'-deoxyguanosine (dOG). Interestingly, dOG is stable but much more labile toward oxidation than dG, furnishing 5-guanidinohydantoin-2'-deoxyribose (dGh) that is favored in the duplex context or spiroiminodihydantoin-2'-deoxyribose (dSp) that is favored in the oxidation of single-stranded contexts. Previously, exposure of DNA to ionizing radiation found ∼50% of the dOG exists as a tandem lesion with an adjacent formamide site...
September 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28930297/estimated-radiation-exposure-of-german-commercial-airline-cabin-crew-in-the-years-1960-2003-modeled-using-dose-registry-data-for-2004-2015
#2
Daniel Wollschläger, Gaël Paul Hammer, Thomas Schafft, Steffen Dreger, Maria Blettner, Hajo Zeeb
Exposure to ionizing radiation of cosmic origin is an occupational risk factor in commercial aircrew. In a historic cohort of 26,774 German aircrew, radiation exposure was previously estimated only for cockpit crew using a job-exposure matrix (JEM). Here, a new method for retrospectively estimating cabin crew dose is developed. The German Federal Radiation Registry (SSR) documents individual monthly effective doses for all aircrew. SSR-provided doses on 12,941 aircrew from 2004 to 2015 were used to model cabin crew dose as a function of age, sex, job category, solar activity, and male pilots' dose; the mean annual effective dose was 2...
September 20, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28928979/ablation-of-a-left-sided-accessory-pathway-with-near-zero-fluoroscopy-in-a-9-year-old-boy
#3
Gabriel Cismaru, Lucian Muresan, Mihai Puiu, Radu Rosu, Gabriel Gusetu, Dana Pop, Dumitru Zdrenghea
Catheter ablation of cardiac arrhythmias in pediatric population is associated with the risk of ionizing radiation on the child. Due to a greater radiation sensitivity in children and a longer life expectancy newer techniques try to reduce the radiation exposure. A new technique for zero-fluoroscopy catheter ablation is described in a 9-year-old boy who had a left-sided concealed accessory pathway. The NAVX Ensite 3D mapping system permits catheter placement inside the venous system and movement inside the heart chambers without the use of X-rays...
September 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28928914/reducing-radiation-exposure-in-an-electrophysiology-lab-with-introduction-of-newer-fluoroscopic-technology
#4
Munish Sharma, Koroush Khalighi
The use of fluoroscopic devices exposes patients and operators to harmful effects of ionizing radiation in an electrophysiology (EP) lab. We sought to know if the newer fluoroscopic technology (Allura Clarity) installed in a hybrid EP helps to reduce prescribed radiation dose. We performed radiation dose analysis of 90 patients who underwent various procedures in the EP lab at a community teaching hospital after the introduction of newer fluoroscopic technology in June of 2016. Watchman device insertion, radiofrequency ablation procedures, permanent pacemaker (PPM)/implantable cardioverter defibrillator (ICD) placement and battery changes were included in the study to compare radiation exposure during different procedures performed commonly in an EP lab...
June 7, 2017: Clinics and Practice
https://www.readbyqxmd.com/read/28925402/contrasting-effects-of-an-mdm2-functional-polymorphism-on-tumor-phenotypes
#5
G J Ortiz, Y Li, S M Post, V Pant, S Xiong, C A Larsson, A K El-Naggar, D G Johnson, G Lozano
MDM2, an E3 ubiquitin ligase, is a potent inhibitor of the p53 tumor suppressor and is elevated in many human cancers that retain wild-type p53. MDM2 SNP309G is a functional polymorphism that results in elevated levels of MDM2 (due to enhanced SP1 binding to the MDM2 promoter) thus decreasing p53 activity. Mdm2(SNP309G/G) mice are more prone to spontaneous tumor formation than Mdm2(SNP309T/T) mice, providing direct evidence for the impact of this SNP in tumor development. We asked whether environmental factors impact SNP309G function and show that SNP309G cooperates with ionizing radiation to exacerbate tumor development...
September 18, 2017: Oncogene
https://www.readbyqxmd.com/read/28925355/loss-of%C3%A2-foxo-rescues-stem-cell-aging-in-drosophila-germ-line
#6
Filippo Artoni, Rebecca Kreipke, Ondina Palmeira, Connor Dixon, Zachary Goldberg, Hannele Ruohola-Baker
Aging stem cells lose the capacity to properly respond to injury and regenerate their residing tissues. Here, we utilized the ability of Drosophila melanogaster germline stem cells (GSCs) to survive exposure to low doses of ionizing radiation (IR) as a model of adult stem cell injury and identified a regeneration defect in aging GSCs: while aging GSCs survive exposure to IR, they fail to reenter the cell cycle and regenerate the germline in a timely manner. Mechanistically, we identify foxo and mTOR homologue, Tor as important regulators of GSC quiescence following exposure to ionizing radiation...
September 19, 2017: ELife
https://www.readbyqxmd.com/read/28921404/effectiveness-of-a-new-lead-shielding-device-and-additional-filter-for-reducing-staff-and-patient-radiation-exposure-during-videofluoroscopic-swallowing-study-using-a-human-phantom
#7
Yoshiaki Morishima, Koichi Chida, Yoshikazu Muroya, Yoshiya Utsumi
Interventional radiology procedures often involve lengthy exposure to fluoroscopy-derived radiation. We therefore devised a videofluoroscopic swallowing study (VFSS) procedure using a human phantom that proved to protect the patient and physician by reducing the radiation dose. We evaluated a new lead-shielding device and separately attached additional filters (1.0-, 2.0-, and 3.0-mm Al filters and a 0.5-mm Cu filter) during VFSS to reduce the patient's entrance skin dose (ESD). A monitor attached to the human phantom's neck measured the ESD...
September 18, 2017: Dysphagia
https://www.readbyqxmd.com/read/28921009/radiation-overexposure-from-repeated-ct-scans-in-young-adults-with-acute-abdominal-pain
#8
Massimo Tonolini, Elena Valconi, Angelo Vanzulli, Roberto Bianco
PURPOSE: The purpose of this study is to assess the dose of ionizing radiation caused by repeated CT scans performed to investigate non-traumatic acute abdominal conditions in young adults. METHODS: Over 26 months, we collected a cohort of patients aged 18 to 45 years who were subject to at least one urgent contrast-enhanced abdomen/pelvis CT. Patients affected with urolithiasis, HIV infection, tumors, and vascular and chronic inflammatory bowel diseases were excluded...
September 18, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28914558/robotics-in-percutaneous-cardiovascular-interventions
#9
Ali Pourdjabbar, Lawrence Ang, Omid Behnamfar, Mitul P Patel, Ryan R Reeves, Paul T Campbell, Ryan D Madder, Ehtisham Mahmud
The fundamental technique of performing percutaneous cardiovascular (CV) interventions has remained unchanged and requires operators to wear heavy lead aprons to minimize exposure to ionizing radiation. Robotic technology is now being utilized in interventional cardiology partially as a direct result of the increasing appreciation of the long-term occupational hazards of the field. This review was undertaken to report the clinical outcomes of percutaneous robotic coronary and peripheral vascular interventions...
September 15, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28913689/the-evaluation-of-protective-effect-of-lycopene-against-genotoxic-influence-of-x-irradiation-in-human-blood-lymphocytes
#10
Aneta Gajowik, Małgorzata M Dobrzyńska
Many studies suggest that exogenous antioxidants may protect cells against DNA damage caused with ionizing radiation. One of the most powerful antioxidants is lycopene (LYC), a carotenoid derived from tomatoes. The aim of this study was to investigate, using the comet assay, whether LYC can act as protectors/modifiers and prevent DNA damage induced in human blood lymphocytes, as well as to mitigate the effects of radiation exposure. In this project, LYC, dissolved in DMSO at a concentration of 10, 20 or 40 μM/ml of cell suspension, was added to the isolated lymphocytes from human blood at appropriate intervals before or after the X-irradiation at doses of 0...
September 14, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28910671/delayed-effects-of-accelerated-heavy-ions-on-the-induction-of-hprt-mutations-in-v79-hamster-cells
#11
Pavel Bláha, Nataliya A Koshlan, Igor V Koshlan, Daria V Petrova, Yulia V Bogdanova, Raisa D Govorun, Viliam Múčka, Evgeny A Krasavin
Fundamental research on the harmful effects of ionizing radiation on living cells continues to be of great interest. Recently, priority has been given to the study of high-charge and high-energy (HZE) ions that comprise a substantial part of the galactic cosmic ray (GCR) spectra that would be encountered during long-term space flights. Moreover, predictions of the delayed genetic effects of high linear energy transfer (LET) exposure is becoming more important as heavy ion therapy use is increasing. This work focuses mainly on the basic research on the delayed effects of HZE ions on V79 Chinese hamster cells, with emphasis on the induction of HPRT mutations after prolonged expression times (ET)...
August 31, 2017: Mutation Research
https://www.readbyqxmd.com/read/28904138/a-restatement-of-the-natural-science-evidence-base-concerning-the-health-effects-of-low-level-ionizing-radiation
#12
REVIEW
Angela R McLean, Ella K Adlen, Elisabeth Cardis, Alex Elliott, Dudley T Goodhead, Mats Harms-Ringdahl, Jolyon H Hendry, Peter Hoskin, Penny A Jeggo, David J C Mackay, Colin R Muirhead, John Shepherd, Roy E Shore, Geraldine A Thomas, Richard Wakeford, H Charles J Godfray
Exposure to ionizing radiation is ubiquitous, and it is well established that moderate and high doses cause ill-health and can be lethal. The health effects of low doses or low dose-rates of ionizing radiation are not so clear. This paper describes a project which sets out to summarize, as a restatement, the natural science evidence base concerning the human health effects of exposure to low-level ionizing radiation. A novel feature, compared to other reviews, is that a series of statements are listed and categorized according to the nature and strength of the evidence that underpins them...
September 13, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28902577/post-irradiation-promotes-susceptibility-to-reprogramming-to-pluripotent-state-in-human-fibroblasts
#13
Seung Bum Lee, Sung-Hoon Han, Min-Jung Kim, Sehwan Shim, Hye-Yun Shin, Sun-Joo Lee, Hye Won Kim, Won-Suk Jang, Songwon Seo, Seongjae Jang, Yanghee Lee, Sunhoo Park
Ionizing radiation causes not only targeted effects in cells that have been directly irradiated but also non-targeted effects in several cell generations after initial exposure. Recent studies suggest that radiation can enrich for a population of stem cells, derived from differentiated cells, through cellular reprogramming. Here, we elucidate the effect of irradiation on reprogramming, subjected to two different responses, using an induced pluripotent stem cell (iPSC) model. iPSCs were generated from non-irradiated cells, directly-irradiated cells, or cells subsequently generated after initial radiation exposure...
September 13, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28900827/lifetime-radiation-exposure-in-patients-with-recurrent-nephrolithiasis
#14
REVIEW
Mohamed A Elkoushy, Sero Andonian
Patients presenting with nephrolithiasis often undergo repeated imaging studies before, during, and after management. Considering the significant risk of stone recurrence in primary stone-formers, repeated imaging studies are not uncommon. Cumulative effects of ionizing radiation exposure from various imaging studies could potentially increase the risk for developing cataracts and solid malignancies in urolithiasis patients. Therefore, practitioners planning or performing imaging studies with ionizing radiation are compelled to keep radiation exposure to humans and the environment as low as possible, thus strictly adhering to the ALARA (As Low as Reasonably Achievable) principles...
September 12, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28898130/imaging-of-children-with-nontraumatic-headaches
#15
Anna Trofimova, Brianna L Vey, Mark E Mullins, David S Wolf, Nadja Kadom
OBJECTIVE: Headache in children is a common symptom and often is worrisome for clinicians and parents because of the breadth of possible underlying significant abnormalities, including meningitis, brain neoplasms, and intracranial hemorrhage. For this reason, many children with headaches undergo neuroimaging. Most neuroimaging studies performed of children with headaches have normal findings but may lead to significant downstream effects, including unnecessary exposure to ionizing radiation or sedation, as well as unnecessary cost to the health care system...
September 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28894775/pregnancy-screening-before-diagnostic-radiography-in-emergency-department-an-educational-review
#16
REVIEW
Abdelrahman Ibrahim Abushouk, Morteza Sanei Taheri, Parichehr Pooransari, Sahar Mirbaha, Alaleh Rouhipour, Alireza Baratloo
In modern medical practice, there is an increasing dependence on imaging techniques in most medical specialties. Radiation exposure during pregnancy may have serious teratogenic effects to the fetus. Therefore, checking the pregnancy status before imaging women of child bearing age can protect against these effects. Lack of international regulations and standard protocols exposes the patient to unexpected fetal radiation effects and the health professionals to medicolegal suits. Recently, the American Academy of Radiology and the European community of Medical Ionizing Radiation Protection released national guidelines regarding pregnancy screening before imaging potentially pregnant females...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28892785/parental-gamma-irradiation-induces-reprotoxic-effects-accompanied-by-genomic-instability-in-zebrafish-danio-rerio-embryos
#17
Selma Hurem, Tânia Gomes, Dag A Brede, Elisabeth Lindbo Hansen, Stephen Mutoloki, Cristian Fernandez, Carmel Mothersill, Brit Salbu, Yetneberk A Kassaye, Ann-Karin Olsen, Deborah Oughton, Peter Aleström, Jan L Lyche
Gamma radiation represents a potential health risk to aquatic and terrestrial biota, due to its ability to ionize atoms and molecules in living tissues. The effects of exposure to (60)Co gamma radiation in zebrafish (Danio rerio) were studied during two sensitive life stages: gametogenesis (F0: 53 and 8.7mGy/h for 27 days, total doses 31 and 5.2Gy) and embryogenesis (9.6mGy/h for 65h; total dose 0.62Gy). Progeny of F0 exposed to 53mGy/h showed 100% mortality occurring at the gastrulation stage corresponding to 8h post fertilization (hpf)...
September 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/28892216/delayed-and-localized-pemphigus-vulgaris-after-breast-cancer-radiotherapy
#18
Hiu Kwan Carolyn Tang, Doreen Yin Hui Lee, Ian Thompson, John R Ingram, Natalie Stone, Girish K Patel
Breast cancer treatment involving ionizing radiation causes characteristic radiation dermatitis in the majority of patients. The DNA damaging effects of radiation can rarely predispose to primary inflammatory dermatoses, such as pemphigus vulgaris. In such cases, the disease presents with all the hallmarks of the primary dermatosis, but the eruption is limited to the field of irradiation and is often amenable to treatment. In contrast, occurrence of generalized pemphigus vulgaris in this setting may mean cancer recurrence...
September 11, 2017: Breast Journal
https://www.readbyqxmd.com/read/28888725/-impact-of-rotational-coronary-angiography-in-the-amount-of-iodinated-contrast-and-the-exposition-to-ionizing-radiations-in-patients-undergoing-invasive-coronary-procedures-a-systematic-review-and-meta-analysis
#19
Diego Fernández-Rodríguez, Leydimar Anmad Shihadeh, José L Martos-Maine, Patricia Couto-Comba, Alejandro Quijada-Fumero, Raquel Pimienta, José J Grillo-Pérez, Marcos Rodríguez-Esteban, Horacio Pérez-Hernández, Julio Hernández-Afonso, Francisco Bosa Ojeda
BACKGROUND: Invasive coronary procedures involve the administration of iodinated contrast and the exposure to ionizing radiations, increasing morbidity and mortality. The rotational coronary angiography (RCA) allows acquiring multiple projections with a unique injection of iodinated contrast. To date, there were no meta-analysis specifically comparing RCA and conventional coronary angiography (CCA) in patients undergoing invasive coronary procedures, whether diagnostic or diagnostic and therapeutic...
September 6, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28885924/research-on-health-effects-of-low-level-ionizing-radiation-exposure-opportunities-for-the-armed-forces-radiobiology-research-institute
#20
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Military Medicine
keyword
keyword
104806
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"