keyword
MENU ▼
Read by QxMD icon Read
search

  Bone marrow necrosis

keyword
https://www.readbyqxmd.com/read/28632753/mait-cells-launch-a-rapid-robust-and-distinct-hyperinflammatory-response-to-bacterial-superantigens-and-quickly-acquire-an-anergic-phenotype-that-impedes-their-cognate-antimicrobial-function-defining-a-novel-mechanism-of-superantigen-induced-immunopathology
#1
Christopher R Shaler, Joshua Choi, Patrick T Rudak, Arash Memarnejadian, Peter A Szabo, Mauro E Tun-Abraham, Jamie Rossjohn, Alexandra J Corbett, James McCluskey, John K McCormick, Olivier Lantz, Roberto Hernandez-Alejandro, S M Mansour Haeryfar
Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a "cytokine storm" with severe and sometimes life-threatening consequences typically encountered in toxic shock syndrome (TSS). Given the rapidity with which TSS develops, designing timely and truly targeted therapies for this syndrome requires identification of key mediators of the cytokine storm's initial wave. Equally important, early host responses to SAgs can be accompanied or followed by a state of immunosuppression, which in turn jeopardizes the host's ability to combat and clear infections...
June 2017: PLoS Biology
https://www.readbyqxmd.com/read/28631177/trail-in-cd8-t-cells-from-patients-with-severe-aplastic-anemia
#2
Chunyan Liu, Mengying Zheng, Tian Zhang, Rong Fu, Huaquan Wang, Ting Wang, Weiwei Qi, Zonghong Shao
Severe aplastic anemia (SAA) is an autoimmune disease caused mainly by activated T lymphocytes. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of TNF family, which can induce apoptosis and play a significant role in the pathogenesis of many autoimmune disorders. In this study, we sought to investigate the role of TRAIL in peripheral CD8+ T cells (CTLs) from SAA patients to clarify the autoimmune mechanisms of bone marrow failure in SAA. The expression of TRAIL and TRAIL-R2 in CTLs from SAA patients and normal controls were determined by flow cytometry, real-time PCR, and western blot...
June 19, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28624824/effect-of-tnf-%C3%AE-inhibition-on-bone-marrow-derived-mesenchymal-stem-cells-in-neurological-function-recovery-after-spinal-cord-injury-via-the-wnt-signaling-pathway-in-a-rat-model
#3
Ren-Jun Peng, Bing Jiang, Xi-Ping Ding, He Huang, Yi-Wei Liao, Gang Peng, Quan Cheng, Jian Xi
AIM: The present study aimed to examine the effect of tumor necrosis factor-α (TNF-α) inhibition on bone marrow-derived mesenchymal stem cells (BMSCs) in neurological function recovery after spinal cord injury (SCI) via the Wnt signaling pathway in a rat model. METHODS: The rat model of SCI was established using Allen's method. Seventy-two adult male Sprague Dawley (SD) rats were randomly assigned into 4 groups (18 rats in each group): the sham control group, saline control group, BMSCs group (injection with BMSCs at the injured site) and BMSCs + TNF-α group (injection with BMSCs under TNF-α treatment at the injured site)...
June 15, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28621565/light-emitting-diode-at-460%C3%A2-%C3%A2-%C3%A2-20%C3%A2-nm-increases-the-production-of-il-12-and-il-6-in-murine-dendritic-cells
#4
Tamires Marielem Carvalho-Costa, Maria Tays Mendes, Marcos Vinicius da Silva, Virmondes Rodrigues, Giuliana Cristina Marre Bruschi Thedei, Carlo Jose Freire Oliveira, Geraldo Thedei
BACKGROUND DATA: Light emitting diode (LED) therapy has been proposed as an option for the treatment of many skin inflammatory processes. Dendritic cells (DCs) are important cells of skin that participate in the initiation and activation of skin immunity. The modulation of these cells by LED could explain much of its effects. OBJECTIVE: Thus, the aim of this study was to examine the effects of LED at 460 ± 20 nm on cytokine production and the expression of surface markers on DCs...
June 15, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28616637/calcaneal-cysts-and-lipomas-a-common-pathogenesis
#5
REVIEW
Jacques Malghem, Frédéric Lecouvet, Bruno Vande Berg
Calcaneal cysts and lipomas are relatively rare, benign bone lesions. They are similar in many ways, including in their location and radiological appearance, but their content differs. Cysts contain fluid whereas lipomas contain fat, although some lesions may exhibit a mixed content. The pathogenesis of the two entities is the subject of controversy. The theory that calcaneal cysts may result from lipomatous necrosis has been widely suggested in the literature, but no such progression has ever been shown. The contrary hypothesis has also been considered, i...
June 14, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28616152/magnetically-levitated-mesenchymal-stem-cell-spheroids-cultured-with-a-collagen-gel-maintain-phenotype-and-quiescence
#6
Natasha S Lewis, Emily El Lewis, Margaret Mullin, Helen Wheadon, Matthew J Dalby, Catherine C Berry
Multicellular spheroids are an established system for three-dimensional cell culture. Spheroids are typically generated using hanging drop or non-adherent culture; however, an emerging technique is to use magnetic levitation. Herein, mesenchymal stem cell spheroids were generated using magnetic nanoparticles and subsequently cultured within a type I collagen gel, with a view towards developing a bone marrow niche environment. Cells were loaded with magnetic nanoparticles, and suspended beneath an external magnet, inducing self-assembly of multicellular spheroids...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28607102/the-dendritic-cell-receptor-dngr-1-promotes-the-development-of-atherosclerosis-in-mice
#7
Yacine Haddad, Charlotte Lahoute, Marc Clément, Ludivine Laurans, Sarvenaz Metghalchi, Lynda Zeboudj, Andreas Giraud, Xavier Loyer, Marie Vandestienne, Julien Wain-Hobson, Bruno Esposito, Stephane Potteaux, Hafid Ait-Oufella, Alain Tedgui, Ziad Mallat, Soraya Taleb
Rationale: Necrotic core formation during the development of atherosclerosis is associated with a chronic inflammatory response and promotes accelerated plaque development and instability. However, the molecular links between necrosis and the development of atherosclerosis are not completely understood. C-type lectin receptor (Clec9a) or DNGR1 is preferentially expressed by the CD8α(+) subset of dendritic cells (CD8α(+)DCs) and is involved in sensing necrotic cells. We hypothesized that sensing of necrotic cells by DNGR1 plays a determinant role in the inflammatory response of atherosclerosis...
June 12, 2017: Circulation Research
https://www.readbyqxmd.com/read/28602846/granulocyte-colony-stimulating-factor-for-the-treatment-of-cardiovascular-diseases-an-update-with-a-critical-appraisal
#8
REVIEW
Domenico D'Amario, Antonio Maria Leone, Josip Anđelo Borovac, Francesco Cannata, Andrea Siracusano, Giampaolo Niccoli, Filippo Crea
Heart failure and acute myocardial infarction are conditions that are associated with high morbidity and mortality. Significant dysfunction of the heart muscle can occur as the consequence of end-stage chronic cardiovascular diseases or acute ischemic events that are marked by large infarction area and significant tissue necrosis. Despite the remarkable improvement of conventional treatments, a substantial proportion of patients still develops severe heart failure that can only be resolved by heart transplantation or mechanical device implantation...
June 7, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28596474/lenalidomide-increases-human-dendritic-cell-maturation-in-multiple-myeloma-patients-targeting-monocyte-differentiation-and-modulating-mesenchymal-stromal-cell-inhibitory-properties
#9
Federica Costa, Rosanna Vescovini, Marina Bolzoni, Valentina Marchica, Paola Storti, Denise Toscani, Fabrizio Accardi, Laura Notarfranchi, Benedetta Dalla Palma, Cristina Manferdini, Sabrina Manni, Giannalisa Todaro, Gina Lisignoli, Francesco Piazza, Franco Aversa, Nicola Giuliani
The use of Lenalidomide (LEN), to reverse tumor-mediated immune suppression and amplify multiple myeloma-specific immunity is currently being explored. Particularly, LEN effects on dendritic cells (DCs) are still unclear. In this study, we investigated the potential effect of LEN on DC differentiation and activity. DCs were differentiated either from CD14+ cells obtained from patients with multiple myeloma or from a human monocytic cell line.LEN, at the concentration range reached in vivo, significantly increased the median intensity expression of HLA-DR, CD86 and CD209 by DCs derived from both bone marrow and peripheral myeloma monocytes and enhanced the production of Interleukin-8, C-C motif chemokine ligand (CCL) 2, CCL5 and tumor necrosis factor-α...
May 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28596375/nlrp3-inflammasome-inhibition-by-mcc950-reduces-atherosclerotic-lesion-development-in-apolipoprotein-e-deficient-mice
#10
Thomas van der Heijden, Eva Kritikou, Wouter Venema, Janine van Duijn, Peter J van Santbrink, Bram Slütter, Amanda C Foks, Ilze Bot, Johan Kuiper
OBJECTIVE: Inflammasomes are multiprotein complexes, and their activation has been associated with cardiovascular disease. Inflammasome activation leads to secretion of caspase-1 by innate immune cells, resulting in the activation of interleukin-1β. Recently, a potent and selective inhibitor of the NLRP3 inflammasome, MCC950, was described. In this study, we investigated the effect of MCC950 on atherosclerotic lesion development in apoE(-/-) mice. APPROACH AND RESULTS: First, we determined the efficacy of MCC950 in vitro...
June 8, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28592915/activated-platelets-induce-an-anti-inflammatory-response-of-monocytes-macrophages-through-cross-regulation-of-pge2-and-cytokines
#11
Bona Linke, Yannick Schreiber, Bettina Picard-Willems, Patrick Slattery, Rolf M Nüsing, Sebastian Harder, Gerd Geisslinger, Klaus Scholich
Platelets are well known for their role in hemostasis and are also increasingly recognized for their roles in the innate immune system during inflammation and their regulation of macrophage activation. Here, we aimed to study the influence of platelets on the production of inflammatory mediators by monocytes and macrophages. Analyzing cocultures of platelets and murine bone marrow-derived macrophages or human monocytes, we found that collagen-activated platelets release high amounts of prostaglandin E2 (PGE2) that leads to an increased interleukin- (IL-) 10 release and a decreased tumor necrosis factor (TNF) α secretion out of the monocytes or macrophages...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28592489/sustained-notch2-signaling-in-osteoblasts-but-no-in-osteoclasts-is-linked-to-osteopenia-in-a-mouse-model-of-hajdu-cheney-syndrome
#12
Stefano Zanotti, Jungeun Yu, Archana Sanjay, Lauren Schilling, Chris Schoenherr, Aris N Economides, Ernesto Canalis
Individuals with Hajdu-Cheney syndrome (HCS) present with osteoporosis, and HCS is associated with NOTCH2 mutations causing deletions of the proline-, glutamic acid-, serine-, and threonine-rich (PEST) domain that are predicted to enhance NOTCH2 stability and cause gain-of-function. Previously, we demonstrated that mice harboring Notch2 mutations analogous to those in HCS (Notch2HCS) are severely osteopenic because of enhanced bone resorption. We attributed this phenotype to osteoclastic sensitization to receptor activator of nuclear factor-κB ligand and increased osteoblastic tumor necrosis factor superfamily member 11 (Tnfsf11) expression...
June 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28588578/grp78-impairs-production-of-lipopolysaccharide-induced-cytokines-by-interaction-with-cd14
#13
Kai Qin, Simin Ma, Heli Li, Min Wu, Yuanli Sun, Mingpeng Fu, Zilong Guo, Huifen Zhu, Feili Gong, Ping Lei, Guanxin Shen
The 78-kDa glucose-regulated protein (GRP78) is a stress-inducible chaperone that resides primarily in the endoplasmic reticulum. GRP78 has been described to be released at times of cellular stress and as having extracellular properties that are anti-inflammatory or favor the resolution of inflammation. In the current study, we confirmed that GRP78 impaired the production of lipopolysaccharide-induced pro-inflammatory cytokines in GRP78-treated bone-marrow-derived dendritic cells (DCs). To explore the underlying mechanism, first of all, GRP78 was checked to be bound to the plasma membrane...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28587347/effect-of-mesenchymal-stem-cells-on-sj%C3%A3-gren-like-mice-and-the-microrna-expression-profiles-of-splenic-cd4-t-cells
#14
Guang-Feng Ruan, Ling Zheng, Jia-Shu Huang, Wan-Xue Huang, Bang-Dong Gong, Xing-Xing Fang, Xiao-Yu Zhang, Jian-Ping Tang
Mesenchymal stem cells (MSCs) serve immuno-regulatory functions and offer a promising novel treatment for certain autoimmune diseases. The present study investigated the therapeutic effect of mice bone marrow (BM)-MSCs on mice with relatively late stage of Sjögren-like disease and the impact of BM-MSCs on the microRNA (miRNA) expression profiles of splenic CD4+ T cells. Female NOD/Ltj mice were randomized into two groups: The disease group (n=8) and the MSC-treated group (n=8). Female ICR mice served as the healthy control group (n=8)...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28580131/recent-insights-into-the-implications-of-metabolism-in-plasmacytoid-dendritic-cell-innate-functions-potential-ways-to-control-these-functions
#15
REVIEW
Philippe Saas, Alexis Varin, Sylvain Perruche, Adam Ceroi
There are more and more data concerning the role of cellular metabolism in innate immune cells, such as macrophages or conventional dendritic cells. However, few data are available currently concerning plasmacytoid dendritic cells (PDC), another type of innate immune cells. These cells are the main type I interferon (IFN) producing cells, but they also secrete other pro-inflammatory cytokines (e.g., tumor necrosis factor or interleukin [IL]-6) or immunomodulatory factors (e.g., IL-10 or transforming growth factor-β)...
2017: F1000Research
https://www.readbyqxmd.com/read/28579235/haematopoietic-tlr4-deletion-attenuates-perivascular-brown-adipose-tissue-inflammation-in-atherosclerotic-mice
#16
Penghao Liu, Gaojian Huang, Zhiyong Cao, Qihai Xie, Tong Wei, Chenglin Huang, Qun Li, Mengwei Sun, Weili Shen, Pingjin Gao
AIMS: To investigate whether haematopoietic TLR4 deletion attenuates perivascular brown adipose tissue inflammation in atherosclerotic mice. METHODS AND RESULTS: Experiments were performed using irradiated LDL receptor-deficient (LDLR-/-) mice with marrow from either TLR4-deficient (TLR4-/-) or age-matched wild-type (WT) mice. After 12weeks of being fed a high-cholesterol diet, TLR4-/-→LDLR-/- mice developed fewer atherosclerotic lesions in the aorta compared to WT→LDLR-/- mice...
June 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28577052/-analysis-of-therapy-relevant-receptors-in-bone-marrow-carcinosis-comparison-of-pathological-and-clinical-parameters
#17
G Massenkeil, C Gropp, H Kreipe, K Hussein
BACKGROUND: Bone marrow carcinosis is a sign of advanced tumor stage with nonspecific clinical and hematological symptoms. Diagnosis is based on bone marrow biopsy and histopathology, but biopsies are not part of the standard work-up in oncological diseases and data on the correlation between clinical presentation and pathological findings are sparse. MATERIAL AND METHODS: In a retrospective single-center study, data from 20 tumor patients with bone marrow carcinosis were analyzed...
June 2, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28574036/-stimulation-of-angiogenesis-by-bone-marrow-cells-in-experimental-ischaemia-of-lower-limb
#18
B S Sukovatykh, A Iu Orlova
The objective of the study was to experimentally substantiate a possibility of treating lower limb chronic ischaemia by means of administration of bone marrow cells. The study was performed on 100 laboratory 'Wistar' rats subdivided into four groups: intact, control, first and second study groups. The intact group consisted of 10 animals, with the remaining three containing 30 rats each. All animals, except the intact ones, were subjected to modelled critical ischaemia of a hind limb by means of excision of major vessels of the extremity...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28566450/monocyte-subtypes-and-the-ccr2-chemokine-receptor-in-cardiovascular-disease
#19
REVIEW
Carolina N França, Maria C O Izar, Marinella N S Hortêncio, Jônatas B do Amaral, Carlos E S Ferreira, Izabela D Tuleta, Francisco A H Fonseca
Monocytes circulate in the blood and migrate to inflammatory tissues, but their functions can be either detrimental or beneficial, depending on their phenotypes. In humans, classical monocytes are inflammatory cluster of differentiation (CD)14(++)CD16(-)CCR2(++) cells originated from the bone marrow or spleen reservoirs and comprise ≥92% of monocytes. Intermediate monocytes (CD14(++)CD16(+)CCR2(+)) are involved in the production of anti-inflammatory cytokines [such as interleukin (IL)-10], reactive oxygen species (ROS), and proinflammatory mediators [such as tumor necrosis factor-α (TNF-α) and IL-1β)...
June 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28562696/pth-1-34-improves-the-effects-of-core-decompression-in-early-stage-steroid-associated-osteonecrosis-model-by-enhancing-bone-repair-and-revascularization
#20
Chen-He Zhou, Jia-Hong Meng, Chen-Chen Zhao, Chen-Yi Ye, Han-Xiao Zhu, Bin Hu, Boon Chin Heng, Yue Shen, Tiao Lin, Xiao-Bo Yang, Zhong-Li Shi, Wei-Liang Shen, Shi-Gui Yan
Steroid-associated osteonecrosis (SAON) might induce bone collapse and subsequently lead to joint arthroplasty. Core decompression (CD) is regarded as an effective therapy for early-stage SAON, but the prognosis is unsatisfactory due to incomplete bone repair. Parathyroid hormone[1-34] (PTH[1-34]) has demonstrated positive efficacy in promoting bone formation. We therefore evaluated the effects of PTH on improving the effects of CD in Early-Stage SAON. Distal femoral CD was performed two weeks after osteonecrosis induction or vehicle injection, with ten of the ON-induced rabbits being subjected to six-week PTH[1-34] treatment and the others, including ON-induced and non-induced rabbits, being treated with vehicle...
2017: PloS One
keyword
keyword
104805
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"