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https://www.readbyqxmd.com/read/28076249/fecal-immunochemical-test-fit-for-colon-cancer-screening-variable-performance-with-ambient-temperature
#1
Chyke A Doubeni, Christopher D Jensen, Stacey A Fedewa, Virginia P Quinn, Ann G Zauber, Joanne E Schottinger, Douglas A Corley, Theodore R Levin
INTRODUCTION: Fecal immunochemical tests (FITs) are widely used in colorectal cancer (CRC) screening, but hemoglobin degradation, due to exposure of the collected sample to high temperatures, could reduce test sensitivity. We examined the relation of ambient temperature exposure with FIT positivity rate and sensitivity. METHODS: This was a retrospective cohort study of patients 50 to 75 years in Kaiser Permanente Northern California's CRC screening program, which began mailing FIT kits annually to screen-eligible members in 2007...
November 2016: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28073866/in-simulation-modelling-there-are-multiple-ways-to-effectively-screen-for-colorectal-cancer
#2
Theodore R Levin
No abstract text is available yet for this article.
January 10, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28044229/genetic-biomarker-prevalence-is-similar-in-fecal-immunochemical-test-positive-and-negative-colorectal-cancer-tissue
#3
Theodore R Levin, Douglas A Corley, Christopher D Jensen, Amy R Marks, Wei K Zhao, Alexis M Zebrowski, Virginia P Quinn, Lawrence W Browne, William R Taylor, David A Ahlquist, Graham P Lidgard, Barry M Berger
BACKGROUND: Fecal immunochemical test (FIT) screening detects most asymptomatic colorectal cancers. Combining FIT screening with stool-based genetic biomarkers increases sensitivity for cancer, but whether DNA biomarkers (biomarkers) differ for cancers detected versus missed by FIT screening has not been evaluated in a community-based population. AIMS: To evaluate tissue biomarkers among Kaiser Permanente Northern California patients diagnosed with colorectal cancer within 2 years after FIT screening...
January 2, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27816694/diverse-neurotoxicants-target-the-differentiation-of-embryonic-neural-stem-cells-into-neuronal-and-glial-phenotypes
#4
Theodore A Slotkin, Samantha Skavicus, Jennifer Card, Edward D Levin, Frederic J Seidler
The large number of compounds that needs to be tested for developmental neurotoxicity drives the need to establish in vitro models to evaluate specific neurotoxic endpoints. We used neural stem cells derived from rat neuroepithelium on embryonic day 14 to evaluate the impact of diverse toxicants on their ability to differentiate into glia and neurons: a glucocorticoid (dexamethasone), organophosphate insecticides (chlorpyrifos, diazinon, parathion), insecticides targeting the GABAA receptor (dieldrin, fipronil), heavy metals (Ni(2+), Ag(+)), nicotine and tobacco smoke extract...
November 30, 2016: Toxicology
https://www.readbyqxmd.com/read/27801886/beyond-colonoscopy-the-role-of-alternative-screening-tests-for-colorectal-cancer-in-your-practice
#5
Theodore R Levin
No abstract text is available yet for this article.
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27769517/recommendations-on-fecal-immunochemical-testing-to-screen-for-colorectal-neoplasia-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal-cancer
#6
Douglas J Robertson, Jeffrey K Lee, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas K Rex
The use of the fecal occult blood test (FOBT) for colorectal cancer (CRC) screening is supported by randomized trials demonstrating effectiveness in cancer prevention and widely recommended by guidelines for this purpose. The fecal immunochemical test (FIT), as a direct measure of human hemoglobin in stool has a number of advantages relative to conventional FOBT and is increasingly used relative to that test. This review summarizes current evidence for FIT in colorectal neoplasia detection and the comparative effectiveness of FIT relative to other commonly used CRC screening modalities...
October 18, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27769516/recommendations-on-fecal-immunochemical-testing-to-screen-for%C3%A2-colorectal-neoplasia-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal-cancer
#7
Douglas J Robertson, Jeffrey K Lee, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas K Rex
No abstract text is available yet for this article.
January 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27753435/recommendations-on-fecal-immunochemical-testing-to-screen-for-colorectal-neoplasia-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal-cancer
#8
Douglas J Robertson, Jeffrey K Lee, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas K Rex
The use of the fecal occult blood test (FOBT) for colorectal cancer (CRC) screening is supported by randomized trials demonstrating effectiveness in cancer prevention and widely recommended by guidelines for this purpose. The fecal immunochemical test (FIT), as a direct measure of human hemoglobin in stool has a number of advantages relative to conventional FOBT and is increasingly used relative to that test. This review summarizes current evidence for FIT in colorectal neoplasia detection and the comparative effectiveness of FIT relative to other commonly used CRC screening modalities...
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27733426/effectiveness-of-screening-colonoscopy-in-reducing-the-risk-of-death-from-right-and-left-colon-cancer-a-large-community-based-study
#9
Chyke A Doubeni, Douglas A Corley, Virginia P Quinn, Christopher D Jensen, Ann G Zauber, Michael Goodman, Jill R Johnson, Shivan J Mehta, Tracy A Becerra, Wei K Zhao, Joanne Schottinger, V Paul Doria-Rose, Theodore R Levin, Noel S Weiss, Robert H Fletcher
OBJECTIVE: Screening colonoscopy's effectiveness in reducing colorectal cancer mortality risk in community populations is unclear, particularly for right-colon cancers, leading to recommendations against its use for screening in some countries. This study aimed to determine whether, among average-risk people, receipt of screening colonoscopy reduces the risk of dying from both right-colon and left-colon/rectal cancers. DESIGN: We conducted a nested case-control study with incidence-density matching in screening-eligible Kaiser Permanente members...
October 12, 2016: Gut
https://www.readbyqxmd.com/read/27702568/endoscopist-fatigue-estimates-and-colonoscopic-adenoma-detection-in-a-large-community-based-setting
#10
Alexander Lee, Christopher D Jensen, Amy R Marks, Wei K Zhao, Chyke A Doubeni, Ann G Zauber, Virginia P Quinn, Theodore R Levin, Douglas A Corley
BACKGROUND AND AIMS: Endoscopist fatigue may impact colonoscopy quality, but prior studies conflict, and minimal data exist from community-based practices where most colonoscopies are performed. METHODS: Within a large, community-based integrated healthcare system, we evaluated the associations among 4 measures of endoscopist fatigue and colonoscopic adenoma detection from 2010 to 2013. Fatigue measures included afternoon versus morning colonoscopy and the number of GI procedures performed before a given colonoscopy, including consideration of prior procedure complexity...
October 1, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27672054/shifts-in-the-fecal-microbiota-associated-with-adenomatous-polyps
#11
Vanessa L Hale, Jun Chen, Stephen Johnson, Sean C Harrington, Tracy C Yab, Thomas C Smyrk, Heidi Nelson, Lisa A Boardman, Brooke R Druliner, Theodore R Levin, Douglas K Rex, Dennis J Ahnen, Peter Lance, David A Ahlquist, Nicholas Chia
BACKGROUND: Adenomatous polyps are the most common precursor to colorectal cancer, the second leading cause of cancer-related death in the United States. We sought to learn more about early events of carcinogenesis by investigating shifts in the gut microbiota of patients with adenomas. METHODS: We analyzed 16S rRNA gene sequences from the fecal microbiota of patients with adenomas (n = 233) and without (n = 547). RESULTS: Multiple taxa were significantly more abundant in patients with adenomas, including Bilophila, Desulfovibrio, proinflammatory bacteria in the genus Mogibacterium, and multiple Bacteroidetes species...
January 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27633979/is-there-a-critical-period-for-the-developmental-neurotoxicity-of-low-level-tobacco-smoke-exposure
#12
Theodore A Slotkin, Ashley Stadler, Samantha Skavicus, Jennifer Card, Jonathan Ruff, Edward D Levin, Frederic J Seidler
Secondhand tobacco smoke exposure in pregnancy increases the risk of neurodevelopmental disorders. We evaluated in rats whether there is a critical period during which tobacco smoke extract (TSE) affects the development of acetylcholine and serotonin systems, prominent targets for adverse effects of nicotine and tobacco smoke. We simulated secondhand smoke exposure by administering TSE so as to produce nicotine concentrations one-tenth those in active smoking, with 3 distinct, 10-day windows: premating, early gestation or late gestation...
January 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27608281/evidence-based-recommendations-on-the-use-of-intravenous-lipid-emulsion-therapy-in-poisoning
#13
Sophie Gosselin, Lotte C G Hoegberg, Robert S Hoffman, Andis Graudins, Christine M Stork, Simon H L Thomas, Samuel J Stellpflug, Bryan D Hayes, Michael Levine, Martin Morris, Andrea Nesbitt-Miller, Alexis F Turgeon, Benoit Bailey, Diane P Calello, Ryan Chuang, Theodore C Bania, Bruno Mégarbane, Ashish Bhalla, Valéry Lavergne
BACKGROUND: Although intravenous lipid emulsion (ILE) was first used to treat life-threatening local anesthetic (LA) toxicity, its use has expanded to include both non-local anesthetic (non-LA) poisoning and less severe manifestations of toxicity. A collaborative workgroup appraised the literature and provides evidence-based recommendations for the use of ILE in poisoning. METHODS: Following a systematic review of the literature, data were summarized in four publications: LA and non-LA poisoning efficacy, adverse effects, and analytical interferences...
December 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27412426/race-ethnicity-and-adoption-of-a-population-health-management-approach-to-colorectal-cancer-screening-in-a-community-based-healthcare-system
#14
Shivan J Mehta, Christopher D Jensen, Virginia P Quinn, Joanne E Schottinger, Ann G Zauber, Reinier Meester, Adeyinka O Laiyemo, Stacey Fedewa, Michael Goodman, Robert H Fletcher, Theodore R Levin, Douglas A Corley, Chyke A Doubeni
BACKGROUND: Screening outreach programs using population health management principles offer services uniformly to all eligible persons, but racial/ethnic colorectal cancer (CRC) screening patterns in such programs are not well known. OBJECTIVE: To examine the association between race/ethnicity and the receipt of CRC screening and timely follow-up of positive results before and after implementation of a screening program. DESIGN: Retrospective cohort study of screen-eligible individuals at the Kaiser Permanente Northern California community-based integrated healthcare delivery system (2004-2013)...
November 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27365335/effects-of-liver-transplantation-on-lipids-and-cardiovascular-disease-in-children-with-homozygous-familial-hypercholesterolemia
#15
Mercedes Martinez, Susan Brodlie, Adam Griesemer, Tomoaki Kato, Patricia Harren, Bruce Gordon, Thomas Parker, Daniel Levine, Theodore Tyberg, Thomas Starc, Iksung Cho, James Min, Kimberly Elmore, Steven Lobritto, Lisa Cooper Hudgins
Homozygous familial hypercholesterolemia (HoFH) is a rare, inherited, life-threatening, metabolic disorder of low-density lipoprotein (LDL) receptor function characterized by elevated serum LDL cholesterol (LDL-C) and rapidly progressive atherosclerotic cardiovascular disease (ACVD). Since LDL receptors are predominantly found on hepatocytes, orthotopic liver transplantation (OLT) has emerged as a viable intervention for HoFH because LDL receptor activity is restored. This study assessed the effects of OLT on ACVD and ACVD risk factors in pediatric patients with HoFH...
August 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27211498/consequences-of-increasing-time-to-colonoscopy-examination%C3%A2-after-positive-result-from-fecal-colorectal-cancer%C3%A2-screening-test
#16
Reinier G S Meester, Ann G Zauber, Chyke A Doubeni, Christopher D Jensen, Virginia P Quinn, Mark Helfand, Jason A Dominitz, Theodore R Levin, Douglas A Corley, Iris Lansdorp-Vogelaar
BACKGROUND & AIMS: Delays in diagnostic testing after a positive result from a screening test can undermine the benefits of colorectal cancer (CRC) screening, but there are few empirical data on the effects of such delays. We used microsimulation modeling to estimate the consequences of time to colonoscopy after a positive result from a fecal immunochemical test (FIT). METHODS: We used an established microsimulation model to simulate an average-risk United States population cohort that underwent annual FIT screening (from ages 50 to 75 years), with follow-up colonoscopy examinations for individuals with positive results (cutoff, 20 μg/g) at different time points in the following 12 months...
October 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26919958/cognitive-and-behavioral-impairments-evoked-by-low-level-exposure-to-tobacco-smoke-components-comparison-with-nicotine-alone
#17
Brandon J Hall, Marty Cauley, Dennis A Burke, Abtin Kiany, Theodore A Slotkin, Edward D Levin
Active maternal smoking has adverse effects on neurobehavioral development of the offspring, with nicotine (Nic) providing much of the underlying causative mechanism. To determine whether the lower exposures caused by second-hand smoke are deleterious, we administered tobacco smoke extract (TSE) to pregnant rats starting preconception and continued through the second postnatal week, corresponding to all 3 trimesters of fetal brain development. Dosing was adjusted to produce maternal plasma Nic concentrations encountered with second-hand smoke, an order of magnitude below those seen in active smokers...
June 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/26897047/colorectal-cancer-screening-80-by-2018-colonoscopists-simply-cannot-do-it-alone
#18
EDITORIAL
Theodore R Levin
No abstract text is available yet for this article.
March 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/26892199/colonoscopy-surveillance-after-colorectal-cancer-resection-recommendations-of-the-us-multi-society-task-force-on-colorectal-cancer
#19
REVIEW
Charles J Kahi, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas J Robertson, Douglas K Rex
The US Multi-Society Task Force has developed updated recommendations to guide health care providers with the surveillance of patients after colorectal cancer (CRC) resection with curative intent. This document is based on a critical review of the literature regarding the role of colonoscopy, flexible sigmoidoscopy, endoscopic ultrasound, fecal testing and CT colonography in this setting. The document addresses the effect of surveillance, with focus on colonoscopy, on patient survival after CRC resection, the appropriate use and timing of colonoscopy for perioperative clearing and for postoperative prevention of metachronous CRC, specific considerations for the detection of local recurrence in the case of rectal cancer, as well as the place of CT colonography and fecal tests in post-CRC surveillance...
March 2016: Gastroenterology
https://www.readbyqxmd.com/read/26871541/colonoscopy-surveillance-after-colorectal-cancer-resection-recommendations-of-the-us-multi-society-task-force-on-colorectal-cancer
#20
Charles J Kahi, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas J Robertson, Douglas K Rex
The US Multi-Society Task Force has developed updated recommendations to guide health care providers with the surveillance of patients after colorectal cancer (CRC) resection with curative intent. This document is based on a critical review of the literature regarding the role of colonoscopy, flexible sigmoidoscopy, endoscopic ultrasound, fecal testing and CT colonography in this setting. The document addresses the effect of surveillance, with focus on colonoscopy, on patient survival after CRC resection, the appropriate use and timing of colonoscopy for perioperative clearing and for postoperative prevention of metachronous CRC, specific considerations for the detection of local recurrence in the case of rectal cancer, as well as the place of CT colonography and fecal tests in post-CRC surveillance...
March 2016: American Journal of Gastroenterology
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