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https://www.readbyqxmd.com/read/28600072/colorectal-cancer-screening-recommendations-for-physicians-and-patients-from-the-u-s-multi-society-task-force-on-colorectal-cancer
#1
Douglas K Rex, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, Theodore R Levin, David Lieberman, Douglas J Robertson
This document updates the colorectal cancer (CRC) screening recommendations of the U.S. Multi-Society Task Force of Colorectal Cancer (MSTF), which represents the American College of Gastroenterology, the American Gastroenterological Association, and The American Society for Gastrointestinal Endoscopy. CRC screening tests are ranked in 3 tiers based on performance features, costs, and practical considerations. The first-tier tests are colonoscopy every 10 years and annual fecal immunochemical test (FIT). Colonoscopy and FIT are recommended as the cornerstones of screening regardless of how screening is offered...
June 2, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28600070/colorectal-cancer-screening-recommendations-for-physicians-and-patients-from-the-u-s-multi-society-task-force-on-colorectal-cancer
#2
Douglas K Rex, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, Theodore R Levin, David Lieberman, Douglas J Robertson
No abstract text is available yet for this article.
May 20, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28555630/colorectal-cancer-screening-recommendations-for-physicians-and-patients-from-the-u-s-multi-society-task-force-on-colorectal-cancer
#3
Douglas K Rex, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, Theodore R Levin, David Lieberman, Douglas J Robertson
This document updates the colorectal cancer (CRC) screening recommendations of the U.S. Multi-Society Task Force of Colorectal Cancer (MSTF), which represents the American College of Gastroenterology, the American Gastroenterological Association, and The American Society for Gastrointestinal Endoscopy. CRC screening tests are ranked in 3 tiers based on performance features, costs, and practical considerations. The first-tier tests are colonoscopy every 10 years and annual fecal immunochemical test (FIT). Colonoscopy and FIT are recommended as the cornerstones of screening regardless of how screening is offered...
June 6, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28444278/association-between-time-to-colonoscopy-after-a-positive-fecal-test-result-and-risk-of-colorectal-cancer-and-cancer-stage-at-diagnosis
#4
Douglas A Corley, Christopher D Jensen, Virginia P Quinn, Chyke A Doubeni, Ann G Zauber, Jeffrey K Lee, Joanne E Schottinger, Amy R Marks, Wei K Zhao, Nirupa R Ghai, Alexander T Lee, Richard Contreras, Charles P Quesenberry, Bruce H Fireman, Theodore R Levin
Importance: The fecal immunochemical test (FIT) is commonly used for colorectal cancer screening and positive test results require follow-up colonoscopy. However, follow-up intervals vary, which may result in neoplastic progression. Objective: To evaluate time to colonoscopy after a positive FIT result and its association with risk of colorectal cancer and advanced-stage disease at diagnosis. Design, Setting, and Participants: Retrospective cohort study (January 1, 2010-December 31, 2014) within Kaiser Permanente Northern and Southern California...
April 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28427954/colorectal-cancer-screening-initiation-after-age-50-years-in-an-organized-program
#5
Stacey A Fedewa, Douglas A Corley, Christopher D Jensen, Wei Zhao, Michael Goodman, Ahmedin Jemal, Kevin C Ward, Theodore R Levin, Chyke A Doubeni
INTRODUCTION: Recent studies report racial disparities among individuals in organized colorectal cancer (CRC) programs; however, there is a paucity of information on CRC screening utilization by race/ethnicity among newly age-eligible adults in such programs. METHODS: This was a retrospective cohort study among Kaiser Permanente Northern California enrollees who turned age 50 years between 2007 and 2012 (N=138,799) and were served by a systemwide outreach and facilitated in-reach screening program based primarily on mailed fecal immunochemical tests to screening-eligible people...
April 17, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28143771/the-best-laid-plans-adaptation-is-an-essential-part-of-going-from-efficacy-research-to-program-implementation
#6
EDITORIAL
Theodore R Levin
No abstract text is available yet for this article.
January 29, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28076249/fecal-immunochemical-test-fit-for-colon-cancer-screening-variable-performance-with-ambient-temperature
#7
Chyke A Doubeni, Christopher D Jensen, Stacey A Fedewa, Virginia P Quinn, Ann G Zauber, Joanne E Schottinger, Douglas A Corley, Theodore R Levin
INTRODUCTION: Fecal immunochemical tests (FITs) are widely used in colorectal cancer (CRC) screening, but hemoglobin degradation, due to exposure of the collected sample to high temperatures, could reduce test sensitivity. We examined the relation of ambient temperature exposure with FIT positivity rate and sensitivity. METHODS: This was a retrospective cohort study of patients 50 to 75 years in Kaiser Permanente Northern California's CRC screening program, which began mailing FIT kits annually to screen-eligible members in 2007...
November 2016: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28073866/in-simulation-modelling-there-are-multiple-ways-to-effectively-screen-for-colorectal-cancer
#8
Theodore R Levin
No abstract text is available yet for this article.
January 10, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28044229/genetic-biomarker-prevalence-is-similar-in-fecal-immunochemical-test-positive-and-negative-colorectal-cancer-tissue
#9
Theodore R Levin, Douglas A Corley, Christopher D Jensen, Amy R Marks, Wei K Zhao, Alexis M Zebrowski, Virginia P Quinn, Lawrence W Browne, William R Taylor, David A Ahlquist, Graham P Lidgard, Barry M Berger
BACKGROUND: Fecal immunochemical test (FIT) screening detects most asymptomatic colorectal cancers. Combining FIT screening with stool-based genetic biomarkers increases sensitivity for cancer, but whether DNA biomarkers (biomarkers) differ for cancers detected versus missed by FIT screening has not been evaluated in a community-based population. AIMS: To evaluate tissue biomarkers among Kaiser Permanente Northern California patients diagnosed with colorectal cancer within 2 years after FIT screening...
January 2, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27816694/diverse-neurotoxicants-target-the-differentiation-of-embryonic-neural-stem-cells-into-neuronal-and-glial-phenotypes
#10
Theodore A Slotkin, Samantha Skavicus, Jennifer Card, Edward D Levin, Frederic J Seidler
The large number of compounds that needs to be tested for developmental neurotoxicity drives the need to establish in vitro models to evaluate specific neurotoxic endpoints. We used neural stem cells derived from rat neuroepithelium on embryonic day 14 to evaluate the impact of diverse toxicants on their ability to differentiate into glia and neurons: a glucocorticoid (dexamethasone), organophosphate insecticides (chlorpyrifos, diazinon, parathion), insecticides targeting the GABAA receptor (dieldrin, fipronil), heavy metals (Ni(2+), Ag(+)), nicotine and tobacco smoke extract...
November 30, 2016: Toxicology
https://www.readbyqxmd.com/read/27801886/beyond-colonoscopy-the-role-of-alternative-screening-tests-for-colorectal-cancer-in-your-practice
#11
Theodore R Levin
No abstract text is available yet for this article.
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27769517/recommendations-on-fecal-immunochemical-testing-to-screen-for-colorectal-neoplasia-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal-cancer
#12
REVIEW
Douglas J Robertson, Jeffrey K Lee, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas K Rex
The use of the fecal occult blood test (FOBT) for colorectal cancer (CRC) screening is supported by randomized trials demonstrating effectiveness in cancer prevention and widely recommended by guidelines for this purpose. The fecal immunochemical test (FIT), as a direct measure of human hemoglobin in stool has a number of advantages relative to conventional FOBT and is increasingly used relative to that test. This review summarizes current evidence for FIT in colorectal neoplasia detection and the comparative effectiveness of FIT relative to other commonly used CRC screening modalities...
April 2017: Gastroenterology
https://www.readbyqxmd.com/read/27769516/recommendations-on-fecal-immunochemical-testing-to-screen-for%C3%A2-colorectal-neoplasia-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal-cancer
#13
Douglas J Robertson, Jeffrey K Lee, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas K Rex
No abstract text is available yet for this article.
January 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27753435/recommendations-on-fecal-immunochemical-testing-to-screen-for-colorectal-neoplasia-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal-cancer
#14
REVIEW
Douglas J Robertson, Jeffrey K Lee, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas K Rex
The use of the fecal occult blood test (FOBT) for colorectal cancer (CRC) screening is supported by randomized trials demonstrating effectiveness in cancer prevention and widely recommended by guidelines for this purpose. The fecal immunochemical test (FIT), as a direct measure of human hemoglobin in stool has a number of advantages relative to conventional FOBT and is increasingly used relative to that test. This review summarizes current evidence for FIT in colorectal neoplasia detection and the comparative effectiveness of FIT relative to other commonly used CRC screening modalities...
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27733426/effectiveness-of-screening-colonoscopy-in-reducing-the-risk-of-death-from-right-and-left-colon-cancer-a-large-community-based-study
#15
Chyke A Doubeni, Douglas A Corley, Virginia P Quinn, Christopher D Jensen, Ann G Zauber, Michael Goodman, Jill R Johnson, Shivan J Mehta, Tracy A Becerra, Wei K Zhao, Joanne Schottinger, V Paul Doria-Rose, Theodore R Levin, Noel S Weiss, Robert H Fletcher
OBJECTIVE: Screening colonoscopy's effectiveness in reducing colorectal cancer mortality risk in community populations is unclear, particularly for right-colon cancers, leading to recommendations against its use for screening in some countries. This study aimed to determine whether, among average-risk people, receipt of screening colonoscopy reduces the risk of dying from both right-colon and left-colon/rectal cancers. DESIGN: We conducted a nested case-control study with incidence-density matching in screening-eligible Kaiser Permanente members...
October 12, 2016: Gut
https://www.readbyqxmd.com/read/27702568/endoscopist-fatigue-estimates-and-colonoscopic-adenoma-detection-in-a-large-community-based-setting
#16
Alexander Lee, Christopher D Jensen, Amy R Marks, Wei K Zhao, Chyke A Doubeni, Ann G Zauber, Virginia P Quinn, Theodore R Levin, Douglas A Corley
BACKGROUND AND AIMS: Endoscopist fatigue may impact colonoscopy quality, but prior studies conflict, and minimal data exist from community-based practices where most colonoscopies are performed. METHODS: Within a large, community-based integrated healthcare system, we evaluated the associations among 4 measures of endoscopist fatigue and colonoscopic adenoma detection from 2010 to 2013. Fatigue measures included afternoon versus morning colonoscopy and the number of GI procedures performed before a given colonoscopy, including consideration of prior procedure complexity...
March 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27672054/shifts-in-the-fecal-microbiota-associated-with-adenomatous-polyps
#17
Vanessa L Hale, Jun Chen, Stephen Johnson, Sean C Harrington, Tracy C Yab, Thomas C Smyrk, Heidi Nelson, Lisa A Boardman, Brooke R Druliner, Theodore R Levin, Douglas K Rex, Dennis J Ahnen, Peter Lance, David A Ahlquist, Nicholas Chia
BACKGROUND: Adenomatous polyps are the most common precursor to colorectal cancer, the second leading cause of cancer-related death in the United States. We sought to learn more about early events of carcinogenesis by investigating shifts in the gut microbiota of patients with adenomas. METHODS: We analyzed 16S rRNA gene sequences from the fecal microbiota of patients with adenomas (n = 233) and without (n = 547). RESULTS: Multiple taxa were significantly more abundant in patients with adenomas, including Bilophila, Desulfovibrio, proinflammatory bacteria in the genus Mogibacterium, and multiple Bacteroidetes species...
January 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27633979/is-there-a-critical-period-for-the-developmental-neurotoxicity-of-low-level-tobacco-smoke-exposure
#18
Theodore A Slotkin, Ashley Stadler, Samantha Skavicus, Jennifer Card, Jonathan Ruff, Edward D Levin, Frederic J Seidler
Secondhand tobacco smoke exposure in pregnancy increases the risk of neurodevelopmental disorders. We evaluated in rats whether there is a critical period during which tobacco smoke extract (TSE) affects the development of acetylcholine and serotonin systems, prominent targets for adverse effects of nicotine and tobacco smoke. We simulated secondhand smoke exposure by administering TSE so as to produce nicotine concentrations one-tenth those in active smoking, with 3 distinct, 10-day windows: premating, early gestation or late gestation...
January 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27608281/evidence-based-recommendations-on-the-use-of-intravenous-lipid-emulsion-therapy-in-poisoning
#19
REVIEW
Sophie Gosselin, Lotte C G Hoegberg, Robert S Hoffman, Andis Graudins, Christine M Stork, Simon H L Thomas, Samuel J Stellpflug, Bryan D Hayes, Michael Levine, Martin Morris, Andrea Nesbitt-Miller, Alexis F Turgeon, Benoit Bailey, Diane P Calello, Ryan Chuang, Theodore C Bania, Bruno Mégarbane, Ashish Bhalla, Valéry Lavergne
BACKGROUND: Although intravenous lipid emulsion (ILE) was first used to treat life-threatening local anesthetic (LA) toxicity, its use has expanded to include both non-local anesthetic (non-LA) poisoning and less severe manifestations of toxicity. A collaborative workgroup appraised the literature and provides evidence-based recommendations for the use of ILE in poisoning. METHODS: Following a systematic review of the literature, data were summarized in four publications: LA and non-LA poisoning efficacy, adverse effects, and analytical interferences...
December 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27412426/race-ethnicity-and-adoption-of-a-population-health-management-approach-to-colorectal-cancer-screening-in-a-community-based-healthcare-system
#20
Shivan J Mehta, Christopher D Jensen, Virginia P Quinn, Joanne E Schottinger, Ann G Zauber, Reinier Meester, Adeyinka O Laiyemo, Stacey Fedewa, Michael Goodman, Robert H Fletcher, Theodore R Levin, Douglas A Corley, Chyke A Doubeni
BACKGROUND: Screening outreach programs using population health management principles offer services uniformly to all eligible persons, but racial/ethnic colorectal cancer (CRC) screening patterns in such programs are not well known. OBJECTIVE: To examine the association between race/ethnicity and the receipt of CRC screening and timely follow-up of positive results before and after implementation of a screening program. DESIGN: Retrospective cohort study of screen-eligible individuals at the Kaiser Permanente Northern California community-based integrated healthcare delivery system (2004-2013)...
November 2016: Journal of General Internal Medicine
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