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https://www.readbyqxmd.com/read/28363489/recommendations-on-surveillance-and-management-of-biallelic-mismatch-repair-deficiency-bmmrd-syndrome-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal%C3%A2-cancer
#1
Carol Durno, C Richard Boland, Shlomi Cohen, Jason A Dominitz, Frank M Giardiello, David A Johnson, Tonya Kaltenbach, T R Levin, David Lieberman, Douglas J Robertson, Douglas K Rex
The US Multi-Society Task Force on Colorectal Cancer, with invited experts, developed a consensus statement and recommendations to assist health care providers with appropriate management of patients with biallelic mismatch repair deficiency (BMMRD) syndrome, also called constitutional mismatch repair deficiency syndrome. This position paper outlines what is known about BMMRD, the unique genetic and clinical aspects of the disease, and reviews the current management approaches to this disorder. This article represents a starting point from which diagnostic and management decisions can undergo rigorous testing for efficacy...
May 2017: Gastroenterology
https://www.readbyqxmd.com/read/28363411/recommendations-on-surveillance-and-management-of-biallelic-mismatch-repair-deficiency-bmmrd-syndrome-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal%C3%A2-cancer
#2
Carol Durno, C Richard Boland, Shlomi Cohen, Jason A Dominitz, Frank M Giardiello, David A Johnson, Tonya Kaltenbach, T R Levin, David Lieberman, Douglas J Robertson, Douglas K Rex
No abstract text is available yet for this article.
May 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28353469/recommendations-on-surveillance-and-management-of-biallelic-mismatch-repair-deficiency-bmmrd-syndrome-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal-cancer
#3
Carol Durno, C Richard Boland, Shlomi Cohen, Jason A Dominitz, Frank M Giardiello, David A Johnson, Tonya Kaltenbach, T R Levin, David Lieberman, Douglas J Robertson, Douglas K Rex
No abstract text is available yet for this article.
May 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28349994/recommendations-on-surveillance-and-management-of-biallelic-mismatch-repair-deficiency-bmmrd-syndrome-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal-cancer
#4
Carol Durno, C Richard Boland, Shlomi Cohen, Jason A Dominitz, Frank M Giardiello, David A Johnson, Tonya Kaltenbach, T R Levin, David Lieberman, Douglas J Robertson, Douglas K Rex
The US Multi-Society Task Force on Colorectal Cancer, with invited experts, developed a consensus statement and recommendations to assist health care providers with appropriate management of patients with biallelic mismatch repair deficiency (BMMRD) syndrome, also called constitutional mismatch repair deficiency syndrome. This position paper outlines what is known about BMMRD, the unique genetic and clinical aspects of the disease, and reviews the current management approaches to this disorder. This article represents a starting point from which diagnostic and management decisions can undergo rigorous testing for efficacy...
May 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28275686/historical-perspective-on-familial-gastric-cancer
#5
REVIEW
C Richard Boland, Matthew B Yurgelun
Gastric cancer is a common disease worldwide, typically associated with acquired chronic inflammation in the stomach, related in most instances to infection by Helicobacter pylori. A small percentage of cases occurs in familial clusters, and some of these can be linked to specific germline mutations. This article reviews the historical background to the current understanding of familial gastric cancer, focuses on the entity of hereditary diffuse gastric cancer, and also reviews the risks for gastric cancer related to a number of other familial genetic diseases...
March 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28271304/non-coding-rna-it-s-not-junk
#6
EDITORIAL
C Richard Boland
No abstract text is available yet for this article.
May 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28245849/the-physician-s-experience-of-changing-clinical-practice-a-struggle-to-unlearn
#7
Divya M Gupta, Richard J Boland, David C Aron
BACKGROUND: Changing clinical practice is a difficult process, best illustrated by the time lag between evidence and use in practice and the extensive use of low-value care. Existing models mostly focus on the barriers to learning and implementing new knowledge. Changing clinical practice, however, includes not only the learning of new practices but also unlearning old and outmoded knowledge. There exists sparse literature regarding the unlearning that takes place at a physician level...
February 28, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28154202/aspirin-induced-chemoprevention-and-response-kinetics-are-enhanced-by-pik3ca-mutations-in-colorectal-cancer-cells
#8
Timothy J Zumwalt, Dominik Wodarz, Natalia L Komarova, Shusuke Toden, Jacob Turner, Jacob Cardenas, John Burn, Andrew T Chan, C Richard Boland, Ajay Goel
This study was designed to determine how aspirin influences the growth kinetics and characteristics of cultured colorectal cancer cells that harbor a variety of different mutational backgrounds, including PIK3CA- and KRAS-activating mutations, and the presence or absence of microsatellite instability. Colorectal cancer cell lines (HCT116, HCT116 + Chr3/5, RKO, SW480, HCT15, CACO2, HT29, and SW48) were treated with pharmacologically relevant doses of aspirin (0.5-10 mmol/L) and evaluated for proliferation and cell-cycle distribution...
March 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28034998/the-methodological-quality-and-effectiveness-of-technology-based-smoking-cessation-interventions-for-disadvantaged-groups-a-systematic-review-and-meta-analysis
#9
REVIEW
Veronica C Boland, Emily A Stockings, Richard P Mattick, Hayden McRobbie, Jamie Brown, Ryan J Courtney
AIMS: To assess the methodological quality and effectiveness of technology-based smoking cessation interventions in disadvantaged groups. METHOD: Four databases (EMBASE, Cochrane, Medline, and PsycInfo) were searched for studies conducted from 1980- May 2016. Randomised controlled trials that compared a behavioural smoking cessation intervention delivered primarily through a technology-based platform (e.g. mobile phone) with a no-intervention comparison group among disadvantaged smokers were included...
December 29, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27982025/morphological-characterization-of-colorectal-cancers-in-the-cancer-genome-atlas-reveals-distinct-morphology-molecular-associations-clinical-and-biological-implications
#10
Jinru Shia, Nikolaus Schultz, Deborah Kuk, Efsevia Vakiani, Sumit Middha, Neil H Segal, Jaclyn F Hechtman, Michael F Berger, Zsofia K Stadler, Martin R Weiser, Jedd D Wolchok, C Richard Boland, Mithat Gönen, David S Klimstra
The Cancer Genome Atlas data on colorectal carcinoma have provided a comprehensive view of the tumor's genomic alterations and their tumorigenic roles. Tumor morphology, however, has not been fully integrated into the analysis. The aim of this study was to explore relevant associations between tumor morphology and the newly characterized genomic alterations in colorectal carcinoma. Two hundred and seven colorectal carcinomas that had undergone whole-exome sequencing as part of The Cancer Genome Atlas project and had adequate virtual images in the cBioPortal for Cancer Genomics constituted our study population...
April 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27956742/17q21-31-duplication-causes-prominent-tau-related-dementia-with-increased-mapt-expression
#11
K Le Guennec, O Quenez, G Nicolas, D Wallon, S Rousseau, A-C Richard, J Alexander, P Paschou, C Charbonnier, C Bellenguez, B Grenier-Boley, D Lechner, M-T Bihoreau, R Olaso, A Boland, V Meyer, J-F Deleuze, P Amouyel, H M Munter, G Bourque, M Lathrop, T Frebourg, R Redon, L Letenneur, J-F Dartigues, O Martinaud, O Kalev, S Mehrabian, L Traykov, T Ströbel, I Le Ber, P Caroppo, S Epelbaum, T Jonveaux, F Pasquier, A Rollin-Sillaire, E Génin, L Guyant-Maréchal, G G Kovacs, J-C Lambert, D Hannequin, D Campion, A Rovelet-Lecrux
To assess the role of rare copy number variations in Alzheimer's disease (AD), we conducted a case-control study using whole-exome sequencing data from 522 early-onset cases and 584 controls. The most recurrent rearrangement was a 17q21.31 microduplication, overlapping the CRHR1, MAPT, STH and KANSL1 genes that was found in four cases, including one de novo rearrangement, and was absent in controls. The increased MAPT gene dosage led to a 1.6-1.9-fold expression of the MAPT messenger RNA. Clinical signs, neuroimaging and cerebrospinal fluid biomarker profiles were consistent with an AD diagnosis in MAPT duplication carriers...
December 13, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27898592/the-hepatitis-c-virus-nonstructural-protein-3-q80k-polymorphism-is-frequently-detected-and-transmitted-among-hiv-infected-msm-in-the-netherlands
#12
Astrid M Newsum, Cynthia K Y Ho, Faydra I Lieveld, Thijs J W van de Laar, Sylvie M Koekkoek, Sjoerd P Rebers, Jan T M van der Meer, Anne M J Wensing, Greet J Boland, Joop E Arends, Karel J van Erpecum, Maria Prins, Richard Molenkamp, Janke Schinkel
OBJECTIVES: The Q80K polymorphism is a naturally occurring resistance-associated variant in the hepatitis C virus (HCV) nonstructural protein 3 (NS3) region and is likely transmissible between hosts. This study describes the Q80K origin and prevalence among HCV risk groups in the Netherlands and examines whether Q80K is linked to specific transmission networks. DESIGN AND METHODS: Stored blood samples from HCV genotype 1a-infected patients were used for PCR and sequencing to reconstruct the NS3 maximum likelihood phylogeny...
January 2, 2017: AIDS
https://www.readbyqxmd.com/read/27889571/-new-cancer-genes-and-inherited-colorectal-cancer-risk-caveat-emptor
#13
EDITORIAL
Matthew B Yurgelun, C Richard Boland
No abstract text is available yet for this article.
January 2017: Gastroenterology
https://www.readbyqxmd.com/read/27769517/recommendations-on-fecal-immunochemical-testing-to-screen-for-colorectal-neoplasia-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal-cancer
#14
Douglas J Robertson, Jeffrey K Lee, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas K Rex
The use of the fecal occult blood test (FOBT) for colorectal cancer (CRC) screening is supported by randomized trials demonstrating effectiveness in cancer prevention and widely recommended by guidelines for this purpose. The fecal immunochemical test (FIT), as a direct measure of human hemoglobin in stool has a number of advantages relative to conventional FOBT and is increasingly used relative to that test. This review summarizes current evidence for FIT in colorectal neoplasia detection and the comparative effectiveness of FIT relative to other commonly used CRC screening modalities...
October 18, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27769516/recommendations-on-fecal-immunochemical-testing-to-screen-for%C3%A2-colorectal-neoplasia-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal-cancer
#15
Douglas J Robertson, Jeffrey K Lee, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas K Rex
No abstract text is available yet for this article.
January 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27753435/recommendations-on-fecal-immunochemical-testing-to-screen-for-colorectal-neoplasia-a-consensus-statement-by-the-us-multi-society-task-force-on-colorectal-cancer
#16
Douglas J Robertson, Jeffrey K Lee, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas K Rex
The use of the fecal occult blood test (FOBT) for colorectal cancer (CRC) screening is supported by randomized trials demonstrating effectiveness in cancer prevention and widely recommended by guidelines for this purpose. The fecal immunochemical test (FIT), as a direct measure of human hemoglobin in stool has a number of advantages relative to conventional FOBT and is increasingly used relative to that test. This review summarizes current evidence for FIT in colorectal neoplasia detection and the comparative effectiveness of FIT relative to other commonly used CRC screening modalities...
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27662552/the-hepatitis-c-virus-ns3-q80k-polymorphism-is-frequently-detected-and-transmitted-among-hiv-infected-msm-in-the-netherlands
#17
Astrid M Newsum, Cynthia K Y Ho, Faydra I Lieveld, Thijs J W Van De Laar, Sylvie M Koekkoek, Sjoerd P Rebers, Jan T M Van Der Meer, Anne M J Wensing, Greet J Boland, Joop E Arends, Karel J Van Erpecum, Maria Prins, Richard Molenkamp, Janke Schinkel
OBJECTIVES: The Q80K polymorphism is a naturally occurring resistance-associated variant (RAV) in the hepatitis C virus (HCV) NS3 region and is likely transmissible between hosts. This study describes the Q80K origin and prevalence among HCV risk groups in the Netherlands and examines whether Q80K is linked to specific transmission networks. DESIGN AND METHODS: Stored blood samples from HCV genotype 1a infected patients were used for PCR and sequencing to reconstruct the NS3 maximum likelihood phylogeny...
September 20, 2016: AIDS
https://www.readbyqxmd.com/read/27553833/exportin-5-functions-as-an-oncogene-and-a-potential-therapeutic-target-in-colorectal-cancer
#18
Kunitoshi Shigeyasu, Yoshinaga Okugawa, Shusuke Toden, C Richard Boland, Ajay Goel
Purpose: Dysregulated expression of miRNAs has emerged as a hallmark feature in human cancers. Exportin-5 (XPO5), a karyopherin family member, is a key protein responsible for transporting precursor miRNAs from the nucleus to the cytoplasm. Although XPO5 is one of the key regulators of miRNA biogenesis, its functional role and potential clinical significance in colorectal cancer remains unclear.Experimental Design: The expression levels of XPO5 were initially assessed in three genomic datasets, followed by determination and validation of the relationship between XPO5 expression and clinicopathologic features in two independent colorectal cancer patient cohorts...
March 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27530657/selenium-supplementation-for-prevention-of-colorectal-adenomas-and-risk-of-associated-type-2-diabetes
#19
Patricia A Thompson, Erin L Ashbeck, Denise J Roe, Liane Fales, Julie Buckmeier, Fang Wang, Achyut Bhattacharyya, Chiu-Hsieh Hsu, H H Sherry Chow, Dennis J Ahnen, C Richard Boland, Russell I Heigh, David E Fay, Stanley R Hamilton, Elizabeth T Jacobs, Maria Elena Martinez, David S Alberts, Peter Lance
BACKGROUND: Selenium supplementation may help to prevent colorectal cancer; as precursors of colorectal cancer, colorectal adenomas are a surrogate for colorectal cancer. Selenium supplementation may increase risk of type 2 diabetes (T2D). METHODS: The Selenium and Celecoxib (Sel/Cel) Trial was a randomized, placebo controlled trial of selenium 200 µg daily as selenized yeast and celecoxib 400 mg once daily, alone or together, for colorectal adenoma prevention...
December 2016: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27530656/celecoxib-for-the-prevention-of-colorectal-adenomas-results-of-a-suspended-randomized-controlled-trial
#20
Patricia A Thompson, Erin L Ashbeck, Denise J Roe, Liane Fales, Julie Buckmeier, Fang Wang, Achyut Bhattacharyya, Chiu-Hsieh Hsu, Sherry H H Chow, Dennis J Ahnen, C Richard Boland, Russell I Heigh, David E Fay, Stanley R Hamilton, Elizabeth T Jacobs, Elena Maria Martinez, David S Alberts, Peter Lance
BACKGROUND: Cyclooxygenase (COX)-2 inhibitors such as celecoxib were designed to preserve anti-inflammatory activity without inhibiting COX-1. Downregulation of COX-2 inhibits colorectal carcinogenesis. METHODS: The Selenium and Celecoxib Trial was a randomized, placebo-controlled trial of once-daily selenium 200 µg and celecoxib 400 mg, alone or together, for colorectal adenoma prevention. Men and women between age 40 and 80 years were eligible following colonoscopic removal of adenomas...
December 2016: Journal of the National Cancer Institute
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